Search

Compact objects across the mass spectrum–from neutron stars to supermassive black holes–are progenitors and/or central engines for some of the most cataclysmic phenomena in the Universe. As such, they are associated with radio emission on a variety of timescales and represent key targets for multi-messenger astronomy. Observations of transients in the radio band can unveil the physics behind their central engines, ejecta, and the properties of their surroundings, crucially complementing information on their progenitors gathered from observations of other messengers (such as gravitational waves and neutrinos). In this contribution, we summarize observational opportunities and challenges ahead in the multi-messenger study of neutron stars and black holes using radio observations. We highlight the specific contribution of current U.S. national radio facilities and discuss expectations for the field focusing on the science that could be enabled by facilities recommended by the 2020 Decadal survey such as the next generation Very Large Array (ngVLA).

We present the results of a James Webb Space Telescope NIRCam and NIRSpec investigation into the young massive star cluster (YMC) population of NGC 3256, the most cluster-rich luminous infrared galaxy in the Great Observatories All Sky LIRG Survey. We detect 3061 compact YMC candidates with a signal-to-noise ratio ≥3 at F150W, F200W, and F335M. Based on yggdrasil stellar population models, we identify 116/3061 sources with F150W – F200W > 0.47 and F200W – F355M > −1.37 colors, suggesting that they are young ( t ≤ 5 Myr), dusty ( A _V = 5−15), and massive ( M _⊙ > 10 ^5 ). This increases the sample of dust-enshrouded YMCs detected in this system by an order of magnitude relative to previous Hubble Space Telescope studies. With NIRSpec integral field unit pointings centered on the northern and southern nucleus, we extract the Pa α and 3.3 μ m polycyclic aromatic hydrocarbon (PAH) equivalent widths for eight bright and isolated YMCs. Variations in both the F200W – F335M color and 3.3 μ m PAH emission with the Pa α line strength suggest a rapid dust clearing ( 0) correspond to sources with E ( B − V ) > 3, which are typically missed in UV-optical studies. This underscores the importance of deep near-infrared imaging for finding and characterizing these very young and dust-embedded sources.

We present the first high-resolution, high-frequency radio continuum survey that fully maps an extragalactic deep field: the 10 GHz survey of the Great Observatories Origins Deep Survey-North (GOODS-N) field. This is a Large Program of the Karl G. Jansky Very Large Array (VLA) that allocated 380 hr of observations using the X -band (8–12 GHz) receivers, leading to a 10 GHz mosaic of the GOODS-N field with an average rms noise σ _n = 671 nJy beam ^−1 and angular resolution θ _1/2 = 0.″22 across 297 arcmin ^2 . To maximize the brightness sensitivity we also produce a low-resolution mosaic with θ _1/2 = 1.″0 and σ _n = 968 nJy beam ^−1 , from which we derive our master catalog containing 256 radio sources detected with peak signal-to-noise ratio ≥ 5. Radio source size and flux density estimates from the high-resolution mosaic are provided in the master catalog as well. The total fraction of spurious sources in the catalog is 0.75%. Monte Carlo simulations are performed to derive completeness corrections of the catalog. We find that the 10 GHz radio source counts in the GOODS-N field agree, in general, with predictions from numerical simulations/models and expectations from 1.4 and 3 GHz radio counts.

The exquisite angular resolution and sensitivity of JWST are opening a new window for our understanding of the Universe. In nearby galaxies, JWST observations are revolutionizing our understanding of the first phases of star formation and the dusty interstellar medium. Nineteen local galaxies spanning a range of properties and morphologies across the star-forming main sequence have been observed as part of the PHANGS-JWST Cycle 1 Treasury program at spatial scales of ∼5–50 pc. Here, we describe pjpipe , an image-processing pipeline developed for the PHANGS-JWST program that wraps around and extends the official JWST pipeline. We release this pipeline to the community as it contains a number of tools generally useful for JWST NIRCam and MIRI observations. Particularly for extended sources, pjpipe products provide significant improvements over mosaics from the MAST archive in terms of removing instrumental noise in NIRCam data, background flux matching, and calibration of relative and absolute astrometry. We show that slightly smoothing F2100W MIRI data to 0.″9 (degrading the resolution by about 30%) reduces the noise by a factor of ≈3. We also present the first public release (DR1.1.0) of the pjpipe processed eight-band 2–21 μ m imaging for all 19 galaxies in the PHANGS-JWST Cycle 1 Treasury program. An additional 55 galaxies will soon follow from a new PHANGS-JWST Cycle 2 Treasury program.

We present a statistical analysis of the local, ≈50–100 pc scale, H α emission at the locations of recent (≤125 yr) supernovae (SNe) in nearby star-forming galaxies. Our sample consists of 32 SNe in 10 galaxies that are targets of the PHANGS-MUSE survey. We find that 41% (13/32) of these SNe occur coincident with a previously identified H ii region. For comparison, H ii regions cover 32% of the area within ±1 kpc of any recent SN. Contrasting this local covering fraction with the fraction of SNe coincident with H ii regions, we find a statistical excess of 7.6% ± 8.7% of all SNe to be associated with H ii regions. This increases to an excess of 19.2% ± 10.4% when considering only core-collapse SNe (CCSNe). These estimates appear to be in good agreement with qualitative results from new, higher-resolution Hubble Space Telescope H α imaging, which also suggests many CCSNe detonate near but not in H ii regions. Our results appear consistent with the expectation that only a modest fraction of stars explode during the first ≲5 Myr of the life of a stellar population when H α emission is expected to be bright. Of the H ii region associated SNe, 85% (11/13) also have associated detected CO (2–1) emission, indicating the presence of molecular gas. The SNe associated with H ii regions have typical extinctions of A _V ∼ 1 mag, consistent with a significant amount of pre-clearing of gas from the region before the SNe explode.

We present new JWST NIRSpec integral field spectroscopy (IFS) data for the luminous infrared galaxy NGC 7469, a nearby (70.6 Mpc) active galaxy with a Seyfert 1.5 nucleus that drives a highly ionized gas outflow and a prominent nuclear star-forming ring. Using the superb sensitivity and high spatial resolution of the JWST instrument NIRSpec IFS, we investigate the role of the Seyfert nucleus in the excitation and dynamics of the circumnuclear gas. Our analysis focuses on the [Fe ii ], H _2 , and hydrogen recombination lines that trace the radiation/shocked-excited molecular and ionized interstellar medium around the active galactic nucleus (AGN). We investigate gas excitation through H _2 /Br γ and [Fe ii ]/Pa β emission line ratios and find that photoionization by the AGN dominates within the central 300 pc of the galaxy except in a small region that shows signatures of shock-heated gas; these shock-heated regions are likely associated with a compact radio jet. In addition, the velocity field and velocity dispersion maps reveal complex gas kinematics. Rotation is the dominant feature, but we also identify noncircular motions consistent with gas inflows as traced by the velocity residuals and the spiral pattern in the Pa α velocity dispersion map. The inflow is 2 orders of magnitude higher than the AGN accretion rate. The compact nuclear radio jet has enough power to drive the highly ionized outflow. This scenario suggests that the inflow and outflow are in a self-regulating feeding–feedback process, with a contribution from the radio jet helping to drive the outflow.

Determining how the galactic environment, especially the high gas densities and complex dynamics in bar-fed galaxy centers, alters the star formation efficiency (SFE) of molecular gas is critical to understanding galaxy evolution. However, these same physical or dynamical effects also alter the emissivity properties of CO, leading to variations in the CO-to-H _2 conversion factor ( α _CO ) that impact the assessment of the gas column densities and thus of the SFE. To address such issues, we investigate the dependence of α _CO on the local CO velocity dispersion at 150 pc scales using a new set of dust-based α _CO measurements and propose a new α _CO prescription that accounts for CO emissivity variations across galaxies. Based on this prescription, we estimate the SFE in a sample of 65 galaxies from the PHANGS–Atacama Large Millimeter/submillimeter Array survey. We find increasing SFE toward high-surface-density regions like galaxy centers, while using a constant or metallicity-based α _CO results in a more homogeneous SFE throughout the centers and disks. Our prescription further reveals a mean molecular gas depletion time of 700 Myr in the centers of barred galaxies, which is overall three to four times shorter than in nonbarred galaxy centers or the disks. Across the galaxy disks, the depletion time is consistently around 2–3 Gyr, regardless of the choice of α _CO prescription. All together, our results suggest that the high level of star formation activity in barred centers is not simply due to an increased amount of molecular gas, but also to an enhanced SFE compared to nonbarred centers or disk regions.

We present JWST Mid-InfraRed Instrument/Medium-Resolution Spectrometer (MIRI/MRS) observations of an infrared luminous disk galaxy, FLS1, at z ∼ 0.54. With a lookback time of 5 Gyr, FLS1 is chronologically at the midpoint between the peak epoch of star formation and the present day. The MRS data provide maps of the atomic fine structure lines [Ar ii ]6.99, [Ar iii ]8.99, [Ne ii ]12.81, and [Ne iii ]15.55 μ m, polycyclic aromatic hydrocarbon (PAH) features at 3.3, 6.2, and 11.3 μ m, and the warm molecular gas indicators H _2 S(5) and H _2 S(3); all these emission features are spatially resolved. We find that the PAH emission is more extended along the northern side of the galaxy when compared to the well-studied star formation tracer [Ne ii ]. The H _2 rotational lines, which are shock indicators, are strongest and most extended on the southern side of the galaxy. [Ar ii ] is the second brightest fine structure line detected in FLS1 and we show that it is a useful kinematic probe that can be detected with JWST out to z ∼ 3. Velocity maps of [Ar ii ] show a rotating disk with signs of turbulence. Our results provide an example of how spatially resolved mid-infrared spectroscopy can allow us to better understand the star formation and interstellar medium conditions in a galaxy halfway back to the peak epoch of galaxy evolution.

We present James Webb Space Telescope (JWST) Near Infrared Spectrograph (NIRSpec) integral field spectroscopy of the nearby luminous infrared galaxy NGC 7469. We take advantage of the high spatial/spectral resolution and wavelength coverage of JWST/NIRSpec to study the 3.3 μ m neutral polycyclic aromatic hydrocarbon (PAH) grain emission on ∼200 pc scales. A clear change in the average grain properties between the star-forming ring and the central AGN is found. Regions in the vicinity of the AGN, with [Ne iii ]/[Ne ii ] > 0.25, tend to have larger grain sizes and lower aliphatic-to-aromatic (3.4/3.3) ratios, indicating that smaller grains are preferentially removed by photodestruction in the vicinity of the AGN. PAH emission at the nucleus is weak and shows a low 11.3/3.3 PAH ratio. We find an overall suppression of the total PAH emission relative to the ionized gas in the central 1 kpc region of the AGN in NGC 7469 compared to what has been observed with Spitzer on 3 kpc scales. However, the fractional 3.3 μ m–to–total PAH power is enhanced in the starburst ring, possibly due to a variety of physical effects on subkiloparsec scales, including recurrent fluorescence of small grains or multiple photon absorption by large grains. Finally, the IFU data show that while the 3.3 μ m PAH-derived star formation rate (SFR) in the ring is 27% higher than that inferred from the [Ne ii ] and [Ne iii ] emission lines, the integrated SFR derived from the 3.3 μ m feature would be underestimated by a factor of 2 due to the deficit of PAHs around the AGN, as might occur if a composite system like NGC 7469 were to be observed at high redshift.

We present James Webb Space Telescope (JWST) imaging of NGC 7469 with the Near-Infrared Camera and the Mid-InfraRed Instrument. NGC 7469 is a nearby, z = 0.01627, luminous infrared galaxy that hosts both a Seyfert Type-1.5 nucleus and a circumnuclear starburst ring with a radius of ∼0.5 kpc. The new near-infrared (NIR) JWST imaging reveals 66 star-forming regions, 37 of which were not detected by Hubble Space Telescope (HST) observations. Twenty-eight of the 37 sources have very red NIR colors that indicate obscurations up to A _v ∼ 7 and a contribution of at least 25% from hot dust emission to the 4.4 μ m band. Their NIR colors are also consistent with young (

JWST/Mid-Infrared Instrument imaging of the nearby galaxies IC 5332, NGC 628, NGC 1365, and NGC 7496 from PHANGS reveals a richness of gas structures that in each case form a quasi-regular network of interconnected filaments, shells, and voids. We examine whether this multiscale network of structure is consistent with the fragmentation of the gas disk through gravitational instability. We use FilFinder to detect the web of filamentary features in each galaxy and determine their characteristic radial and azimuthal spacings. These spacings are then compared to estimates of the most Toomre-unstable length (a few kiloparsecs), the turbulent Jeans length (a few hundred parsecs), and the disk scale height (tens of parsecs) reconstructed using PHANGS–Atacama Large Millimeter/submillimeter Array observations of the molecular gas as a dynamical tracer. Our analysis of the four galaxies targeted in this work indicates that Jeans-scale structure is pervasive. Future work will be essential for determining how the structure observed in gas disks impacts not only the rate and location of star formation but also how stellar feedback interacts positively or negatively with the surrounding multiphase gas reservoir.

The PHANGS collaboration has been building a reference data set for the multiscale, multiphase study of star formation and the interstellar medium (ISM) in nearby galaxies. With the successful launch and commissioning of JWST, we can now obtain high-resolution infrared imaging to probe the youngest stellar populations and dust emission on the scales of star clusters and molecular clouds (∼5–50 pc). In Cycle 1, PHANGS is conducting an eight-band imaging survey from 2 to 21 μ m of 19 nearby spiral galaxies. Optical integral field spectroscopy, CO(2–1) mapping, and UV-optical imaging for all 19 galaxies have been obtained through large programs with ALMA, VLT-MUSE, and Hubble. PHANGS–JWST enables a full inventory of star formation, accurate measurement of the mass and age of star clusters, identification of the youngest embedded stellar populations, and characterization of the physical state of small dust grains. When combined with Hubble catalogs of ∼10,000 star clusters, MUSE spectroscopic mapping of ∼20,000 H ii regions, and ∼12,000 ALMA-identified molecular clouds, it becomes possible to measure the timescales and efficiencies of the earliest phases of star formation and feedback, build an empirical model of the dependence of small dust grain properties on local ISM conditions, and test our understanding of how dust-reprocessed starlight traces star formation activity, all across a diversity of galactic environments. Here we describe the PHANGS–JWST Treasury survey, present the remarkable imaging obtained in the first few months of science operations, and provide context for the initial results presented in the first series of PHANGS–JWST publications.

We present a high-resolution view of bubbles within the Phantom Galaxy (NGC 628), a nearby (∼10 Mpc), star-forming (∼2 M _⊙ yr ^−1 ), face-on ( i ∼ 9°) grand-design spiral galaxy. With new data obtained as part of the Physics at High Angular resolution in Nearby GalaxieS (PHANGS)-JWST treasury program, we perform a detailed case study of two regions of interest, one of which contains the largest and most prominent bubble in the galaxy (the Phantom Void, over 1 kpc in diameter), and the other being a smaller region that may be the precursor to such a large bubble (the Precursor Phantom Void). When comparing to matched-resolution H α observations from the Hubble Space Telescope, we see that the ionized gas is brightest in the shells of both bubbles, and is coincident with the youngest (∼1 Myr) and most massive (∼10 ^5 M _⊙ ) stellar associations. We also find an older generation (∼20 Myr) of stellar associations is present within the bubble of the Phantom Void. From our kinematic analysis of the H I , H _2 (CO), and H ii gas across the Phantom Void, we infer a high expansion speed of around 15 to 50 km s ^−1 . The large size and high expansion speed of the Phantom Void suggest that the driving mechanism is sustained stellar feedback due to multiple mechanisms, where early feedback first cleared a bubble (as we observe now in the Precursor Phantom Void), and since then supernovae have been exploding within the cavity and have accelerated the shell. Finally, comparison to simulations shows a striking resemblance to our JWST observations, and suggests that such large-scale, stellar-feedback-driven bubbles should be common within other galaxies.

We present a comparison of theoretical predictions of dust continuum and polycyclic aromatic hydrocarbon (PAH) emission with new JWST observations in three nearby galaxies: NGC 628, NGC 1365, and NGC 7496. Our analysis focuses on a total of 1063 compact stellar clusters and 2654 stellar associations previously characterized by the Hubble Space Telescope in the three galaxies. We find that the distributions and trends in the observed PAH-focused infrared colors generally agree with theoretical expectations, and that the bulk of the observations is more aligned with models of larger, ionized PAHs. These JWST data usher in a new era of probing interstellar dust and studying how the intense radiation fields near stellar clusters and associations play a role in shaping the physical properties of PAHs.

We present maps of the 3.3 μ m polycyclic aromatic hydrocarbon (PAH) emission feature in NGC 628, NGC 1365, and NGC 7496 as observed with the Near-Infrared Camera imager on JWST from the PHANGS–JWST Cycle 1 Treasury project. We create maps that isolate the 3.3 μ m PAH feature in the F335M filter (F335M _PAH ) using combinations of the F300M and F360M filters for removal of starlight continuum. This continuum removal is complicated by contamination of the F360M by PAH emission and variations in the stellar spectral energy distribution slopes between 3.0 and 3.6 μ m. We modify the empirical prescription from Lai et al. to remove the starlight continuum in our highly resolved galaxies, which have a range of starlight- and PAH-dominated lines of sight. Analyzing radially binned profiles of the F335M _PAH emission, we find that between 5% and 65% of the F335M intensity comes from the 3.3 μ m feature within the inner 0.5 r _25 of our targets. This percentage systematically varies from galaxy to galaxy and shows radial trends within the galaxies related to each galaxy’s distribution of stellar mass, interstellar medium, and star formation. The 3.3 μ m emission is well correlated with the 11.3 μ m PAH feature traced with the MIRI F1130W filter, as is expected, since both features arise from C–H vibrational modes. The average F335M _PAH /F1130W ratio agrees with the predictions of recent models by Draine et al. for PAHs with size and charge distributions shifted toward larger grains with normal or higher ionization.

JWST observations of polycyclic aromatic hydrocarbon (PAH) emission provide some of the deepest and highest resolution views of the cold interstellar medium (ISM) in nearby galaxies. If PAHs are well mixed with the atomic and molecular gas and illuminated by the average diffuse interstellar radiation field, PAH emission may provide an approximately linear, high-resolution, high-sensitivity tracer of diffuse gas surface density. We present a pilot study that explores using PAH emission in this way based on Mid-Infrared Instrument observations of IC 5332, NGC 628, NGC 1365, and NGC 7496 from the Physics at High Angular resolution in Nearby GalaxieS-JWST Treasury. Using scaling relationships calibrated in Leroy et al., scaled F1130W provides 10–40 pc resolution and 3 σ sensitivity of Σ _gas ∼ 2 M _⊙ pc ^−2 . We characterize the surface densities of structures seen at

We present the results of a James Webb Space Telescope NIRCam investigation into the young massive star cluster (YMC) population in the luminous infrared galaxy VV 114. We identify 374 compact YMC candidates with signal-to-noise ratios ≥ 3, 5, and 5 at F150W, F200W, and F356W, respectively. A direct comparison with our HST cluster catalog reveals that ∼20% of these sources are undetected at optical wavelengths. Based on yggdrasil stellar population models, we identify 17 YMC candidates in our JWST imaging alone with F150W – F200W and F200W – F356W colors suggesting they are all very young, dusty ( A _V = 5–15), and massive (10 ^5.8 < M _⊙ < 10 ^6.1 ). The discovery of these “hidden” sources, many of which are found in the “overlap” region between the two nuclei, quadruples the number of t < 3 Myr clusters and nearly doubles the number of t < 6 Myr clusters detected in VV 114. Now extending the cluster age distribution ( ${dN}/d\tau \propto {\tau }^{\gamma }$ ) to the youngest ages, we find a slope of γ = −1.30 ± 0.39 for 10 ^6 < τ (yr) < 10 ^7 , which is consistent with the previously determined value from 10 ^7 < τ (yr) < 10 ^8.5 , and confirms that VV 114 has a steep age distribution slope for all massive star clusters across the entire range of cluster ages observed. Finally, the consistency between our JWST- and HST-derived age distribution slopes indicates that the balance between cluster formation and destruction has not been significantly altered in VV 114 over the last 0.5 Gyr.

We compare mid-infrared (mid-IR), extinction-corrected H α , and CO (2–1) emission at 70–160 pc resolution in the first four PHANGS–JWST targets. We report correlation strengths, intensity ratios, and power-law fits relating emission in JWST’s F770W, F1000W, F1130W, and F2100W bands to CO and H α . At these scales, CO and H α each correlate strongly with mid-IR emission, and these correlations are each stronger than the one relating CO to H α emission. This reflects that mid-IR emission simultaneously acts as a dust column density tracer, leading to a good match with the molecular-gas-tracing CO, and as a heating tracer, leading to a good match with the H α . By combining mid-IR, CO, and H α at scales where the overall correlation between cold gas and star formation begins to break down, we are able to separate these two effects. We model the mid-IR above I _ν = 0.5 MJy sr ^−1 at F770W, a cut designed to select regions where the molecular gas dominates the interstellar medium (ISM) mass. This bright emission can be described to first order by a model that combines a CO-tracing component and an H α -tracing component. The best-fitting models imply that ∼50% of the mid-IR flux arises from molecular gas heated by the diffuse interstellar radiation field, with the remaining ∼50% associated with bright, dusty star-forming regions. We discuss differences between the F770W, F1000W, and F1130W bands and the continuum-dominated F2100W band and suggest next steps for using the mid-IR as an ISM tracer.

Polycyclic aromatic hydrocarbons (PAHs) play a critical role in the reprocessing of stellar radiation and balancing the heating and cooling processes in the interstellar medium but appear to be destroyed in H ii regions. However, the mechanisms driving their destruction are still not completely understood. Using PHANGS–JWST and PHANGS–MUSE observations, we investigate how the PAH fraction changes in about 1500 H ii regions across four nearby star-forming galaxies (NGC 628, NGC 1365, NGC 7496, and IC 5332). We find a strong anticorrelation between the PAH fraction and the ionization parameter (the ratio between the ionizing photon flux and the hydrogen density) of H ii regions. This relation becomes steeper for more luminous H ii regions. The metallicity of H ii regions has only a minor impact on these results in our galaxy sample. We find that the PAH fraction decreases with the H α equivalent width—a proxy for the age of the H ii regions—although this trend is much weaker than the one identified using the ionization parameter. Our results are consistent with a scenario where hydrogen-ionizing UV radiation is the dominant source of PAH destruction in star-forming regions.

Large-scale bars can fuel galaxy centers with molecular gas, often leading to the development of dense ringlike structures where intense star formation occurs, forming a very different environment compared to galactic disks. We pair ∼0.″3 (30 pc) resolution new JWST/MIRI imaging with archival ALMA CO(2–1) mapping of the central ∼5 kpc of the nearby barred spiral galaxy NGC 1365 to investigate the physical mechanisms responsible for this extreme star formation. The molecular gas morphology is resolved into two well-known bright bar lanes that surround a smooth dynamically cold gas disk ( R _gal ∼ 475 pc) reminiscent of non-star-forming disks in early-type galaxies and likely fed by gas inflow triggered by stellar feedback in the lanes. The lanes host a large number of JWST-identified massive young star clusters. We find some evidence for temporal star formation evolution along the ring. The complex kinematics in the gas lanes reveal strong streaming motions and may be consistent with convergence of gas streamlines expected there. Indeed, the extreme line widths are found to be the result of inter-“cloud” motion between gas peaks; ScousePy decomposition reveals multiple components with line widths of 〈 σ _CO,scouse 〉 ≈ 19 km s ^−1 and surface densities of $\langle \,{{\rm{\Sigma }}}_{{{\rm{H}}}_{2},\mathrm{scouse}}\rangle \,\approx \,800\,{M}_{\odot }\,{\mathrm{pc}}^{-2}$ , similar to the properties observed throughout the rest of the central molecular gas structure. Tailored hydrodynamical simulations exhibit many of the observed properties and imply that the observed structures are transient and highly time-variable. From our study of NGC 1365, we conclude that it is predominantly the high gas inflow triggered by the bar that is setting the star formation in its CMZ.

We measure empirical relationships between the local star formation rate (SFR) and properties of the star-forming molecular gas on 1.5 kpc scales across 80 nearby galaxies. These relationships, commonly referred to as “star formation laws,” aim at predicting the local SFR surface density from various combinations of molecular gas surface density, galactic orbital time, molecular cloud free fall time, and the interstellar medium dynamical equilibrium pressure. Leveraging a multiwavelength database built for the Physics at High Angular Resolution in Nearby Galaxies (PHANGS) survey, we measure these quantities consistently across all galaxies and quantify systematic uncertainties stemming from choices of SFR calibrations and the CO-to-H _2 conversion factors. The star formation laws we examine show 0.3–0.4 dex of intrinsic scatter, among which the molecular Kennicutt–Schmidt relation shows a ∼10% larger scatter than the other three. The slope of this relation ranges β ≈ 0.9–1.2, implying that the molecular gas depletion time remains roughly constant across the environments probed in our sample. The other relations have shallower slopes ( β ≈ 0.6–1.0), suggesting that the star formation efficiency per orbital time, the star formation efficiency per free fall time, and the pressure-to-SFR surface density ratio (i.e., the feedback yield) vary systematically with local molecular gas and SFR surface densities. Last but not least, the shapes of the star formation laws depend sensitively on methodological choices. Different choices of SFR calibrations can introduce systematic uncertainties of at least 10%–15% in the star formation law slopes and 0.15–0.25 dex in their normalization, while the CO-to-H _2 conversion factors can additionally produce uncertainties of 20%–25% for the slope and 0.10–0.20 dex for the normalization.

James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI) images of the luminous infrared (IR) galaxy VV 114 are presented. This redshift ∼0.020 merger has a western component (VV 114W) rich in optical star clusters and an eastern component (VV 114E) hosting a luminous mid-IR nucleus hidden at UV and optical wavelengths by dust lanes. With MIRI, the VV 114E nucleus resolves primarily into bright NE and SW cores separated by 630 pc. This nucleus comprises 45% of the 15 μ m light of VV 114, with the NE and SW cores having IR luminosities, L _IR (8 − 1000 μ m) ∼ 8 ± 0.8 × 10 ^10 L _⊙ and ∼ 5 ± 0.5 × 10 ^10 L _⊙ , respectively, and IR densities, Σ _IR ≳ 2 ± 0.2 × 10 ^13 L _⊙ kpc ^−2 and ≳ 7 ± 0.7 × 10 ^12 L _⊙ kpc ^−2 , respectively—in the range of Σ _IR for the Orion star-forming core and the nuclei of Arp 220. The NE core, previously speculated to have an active galactic nucleus (AGN), has starburst-like mid-IR colors. In contrast, the VV 114E SW core has AGN-like colors. Approximately 40 star-forming knots with L _IR ∼ 0.02–5 × 10 ^10 L _⊙ are identified, 28% of which have no optical counterpart. Finally, diffuse emission accounts for 40%–60% of the mid-IR emission. Mostly notably, filamentary polycyclic aromatic hydrocarbon (PAH) emission stochastically excited by UV and optical photons accounts for half of the 7.7 μ m light of VV 114. This study illustrates the ability of JWST to detect obscured compact activity and distributed PAH emission in the most extreme starburst galaxies in the local universe.

We have used the Mid-InfraRed Instrument (MIRI) on the James Webb Space Telescope (JWST) to obtain the first spatially resolved, mid-infrared images of IIZw096, a merging luminous infrared galaxy (LIRG) at z = 0.036. Previous observations with the Spitzer Space Telescope suggested that the vast majority of the total IR luminosity ( L _IR ) of the system originated from a small region outside of the two merging nuclei. New observations with JWST/MIRI now allow an accurate measurement of the location and luminosity density of the source that is responsible for the bulk of the IR emission. We estimate that 40%–70% of the IR bolometric luminosity, or 3–5 × 10 ^11 L _⊙ , arises from a source no larger than 175 pc in radius, suggesting a luminosity density of at least 3–5 × 10 ^12 L _⊙ kpc ^−2 . In addition, we detect 11 other star-forming sources, five of which were previously unknown. The MIRI F1500W/F560W colors of most of these sources, including the source responsible for the bulk of the far-IR emission, are much redder than the nuclei of local LIRGs. These observations reveal the power of JWST to disentangle the complex regions at the hearts of merging, dusty galaxies.

The nearby, luminous infrared galaxy NGC 7469 hosts a Seyfert nucleus with a circumnuclear star-forming ring and is thus the ideal local laboratory for investigating the starburst–AGN (active galactic nucleus) connection in detail. We present integral-field observations of the central 1.3 kpc region in NGC 7469 obtained with the JWST Mid-InfraRed Instrument. Molecular and ionized gas distributions and kinematics at a resolution of ∼100 pc over the 4.9–7.6 μ m region are examined to study the gas dynamics influenced by the central AGN. The low-ionization [Fe ii ] λ 5.34 μ m and [Ar ii ] λ 6.99 μ m lines are bright on the nucleus and in the starburst ring, as opposed to H _2 S(5) λ 6.91 μ m, which is strongly peaked at the center and surrounding ISM. The high-ionization [Mg v ] line is resolved and shows a broad, blueshifted component associated with the outflow. It has a nearly face-on geometry that is strongly peaked on the nucleus, where it reaches a maximum velocity of −650 km s ^−1 , and extends about 400 pc to the east. Regions of enhanced velocity dispersion in H _2 and [Fe ii ] ∼ 180 pc from the AGN that also show high L (H _2 )/ L (PAH) and L ([Fe ii ])/ L (Pf α ) ratios to the W and N of the nucleus pinpoint regions where the ionized outflow is depositing energy, via shocks, into the dense interstellar medium between the nucleus and the starburst ring. These resolved mid-infrared observations of the nuclear gas dynamics demonstrate the power of JWST and its high-sensitivity integral-field spectroscopic capability to resolve feedback processes around supermassive black holes in the dusty cores of nearby luminous infrared galaxies.

We present James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI) integral-field spectroscopy of the nearby merging, luminous infrared galaxy, NGC 7469. This galaxy hosts a Seyfert type-1.5 nucleus, a highly ionized outflow, and a bright, circumnuclear star-forming ring, making it an ideal target to study active galactic nucleus (AGN) feedback in the local universe. We take advantage of the high spatial/spectral resolution of JWST/MIRI to isolate the star-forming regions surrounding the central active nucleus and study the properties of the dust and warm molecular gas on ∼100 pc scales. The starburst ring exhibits prominent polycyclic aromatic hydrocarbon (PAH) emission, with grain sizes and ionization states varying by only ∼30%, and a total star formation rate of 10–30 M _⊙ yr ^−1 derived from fine structure and recombination emission lines. Using pure rotational lines of H _2 we detect 1.2 × 10 ^7 M _⊙ of warm molecular gas at a temperature higher than 200 K in the ring. All PAH bands get significantly weaker toward the central source, where larger and possibly more ionized grains dominate the emission, likely the result of the ionizing radiation and/or the fast wind emerging from the AGN. The small grains and warm molecular gas in the bright regions of the ring however display properties consistent with normal star-forming regions. These observations highlight the power of JWST to probe the inner regions of dusty, rapidly evolving galaxies for signatures of feedback and inform models that seek to explain the coevolution of supermassive black holes and their hosts.

The CO-to-H _2 conversion factor ( α _CO ) is central to measuring the amount and properties of molecular gas. It is known to vary with environmental conditions, and previous studies have revealed lower α _CO in the centers of some barred galaxies on kiloparsec scales. To unveil the physical drivers of such variations, we obtained Atacama Large Millimeter/submillimeter Array bands (3), (6), and (7) observations toward the inner ∼2 kpc of NGC 3627 and NGC 4321 tracing ^12 CO, ^13 CO, and C ^18 O lines on ∼100 pc scales. Our multiline modeling and Bayesian likelihood analysis of these data sets reveal variations of molecular gas density, temperature, optical depth, and velocity dispersion, which are among the key drivers of α _CO . The central 300 pc nuclei in both galaxies show strong enhancement of temperature T _k ≳ 100 K and density ${n}_{{{\rm{H}}}_{2}}\gt {10}^{3}$ cm ^−3 . Assuming a CO-to-H _2 abundance of 3 × 10 ^−4 , we derive 4–15 times lower α _CO than the Galactic value across our maps, which agrees well with previous kiloparsec-scale measurements. Combining the results with our previous work on NGC 3351, we find a strong correlation of α _CO with low- J ^12 CO optical depths ( τ _CO ), as well as an anticorrelation with T _k . The τ _CO correlation explains most of the α _CO variation in the three galaxy centers, whereas changes in T _k influence α _CO to second order. Overall, the observed line width and ^12 CO/ ^13 CO 2–1 line ratio correlate with τ _CO variation in these centers, and thus they are useful observational indicators for α _CO variation. We also test current simulation-based α _CO prescriptions and find a systematic overprediction, which likely originates from the mismatch of gas conditions between our data and the simulations.

We report the observation by the Atacama Large Millimeter/submillimeter Array (ALMA) of a z ≳ 10 galaxy candidate (GHZ1) discovered from the GLASS–JWST Early Release Science Program. Our ALMA program aims to detect the [O iii ] emission line at the rest-frame frequency 3393.0062 GHz (88.36 μ m) and far-IR continuum emission with the spectral window setup seamlessly covering a 26.125 GHz frequency range (10.10 < z < 11.14). A total of 7 hr of on-source integration was employed, using four frequency settings to cover the full range (1.7 hr per setting), with 0.″7 angular resolution. No line or continuum is clearly detected, with 5 σ upper limits on the line emission of 0.93 mJy beam ^−1 at 25 km s ^−1 channel ^−1 and on the continuum emission of 30 μ Jy beam ^−1 . We report marginal spectral (at 225 km s ^−1 resolution) and continuum features (4.1 σ and 2.6 σ peak signal-to-noise ratio, respectively), within 0.″17 from the JWST position of GHZ1. This spectral feature implies z = 10.38 and needs to be verified with further observations. Assuming that the best estimate of photometric redshift ( $z={10.60}_{-0.60}^{+0.52}$ ) is correct, the model of the galaxy’s broadband spectral energy distribution for the 3 σ upper limit of the continuum flux from GHZ1 suggests that GHZ1 has a small amount of dust ( M _d ≲ 10 ^4 M _⊙ ) at a high temperature ( T _d ≳ 90 K). The 5 σ upper limit on the [O iii ] _88 _μ _m line luminosity and the inferred star formation rate of GHZ1 are consistent with the properties of low-metallicity dwarf galaxies. We also report serendipitous clear detections of six continuum sources at the locations of the JWST galaxy counterparts in the field.

We present the initial results of an ongoing survey with the Karl G. Jansky Very Large Array targeting the CO( J = 1–0) transition in a sample of 30 submillimeter-selected, dusty star-forming galaxies (SFGs) at z = 2–5 with existing mid- J CO detections from the Atacama Large Millimeter/submillimeter Array and NOrthern Extended Millimeter Array, of which 17 have been fully observed. We detect CO(1–0) emission in 11 targets, along with three tentative (∼1.5 σ –2 σ ) detections; three galaxies are undetected. Our results yield total molecular gas masses of 6–23 × 10 ^10 ( α _CO /1) M _⊙ , with gas mass fractions, f _gas = M _mol /( M _* + M _mol ), of 0.1–0.8 and a median depletion time of (140 ± 70) Myr. We find median CO excitation ratios of r _31 = 0.75 ± 0.39 and r _41 = 0.63 ± 0.44, with significant scatter. We find no significant correlation between the excitation ratio and a number of key parameters such as redshift, CO(1–0) line width, or Σ _SFR . We only find a tentative positive correlation between r _41 and the star-forming efficiency, but we are limited by our small sample size. Finally, we compare our results to predictions from the SHARK semi-analytical model, finding a good agreement between the molecular gas masses, depletion times, and gas fractions of our sources and their SHARK counterparts. Our results highlight the heterogeneous nature of the most massive SFGs at high redshift, and the importance of CO(1–0) observations to robustly constrain their total molecular gas content and interstellar medium properties.

High-performance liquid chromatography with tandem mass spectrometry detection (LC-MS/MS) allows a highly selective, sensitive, simultaneous analysis for prostanoids (PG) without derivatization. However, high chemical background noise reduces LC-MS/MS selectivity and sensitivity for brain PG analysis. Four common methods using different solvent systems for PG extraction were tested. Although these methods had the same recovery of PG, the modified acetone extraction followed by liquid/liquid purification had the greatest sensitivity. This method combined with hexane/2-propanol extraction permits the simultaneous analysis of other lipid molecules and PG in the same extract. We also determined that PG mass in brain powder stored at −80°C was reduced 2- to 4- fold in 4 weeks; however, PG were stable for long periods (>3 months) in hexane/2-propanol extracts. PG mass was increased significantly when mice were euthanized by decapitation and the brains rapidly flash-frozen rather than euthanized using head-focused microwave irradiation. This reduction is not the result of PG trapping or destruction in microwave-irradiated brains, demonstrating its importance in limiting mass artifacts during brain PG analysis. Our improved procedure for brain PG analysis provides a reliable, rapid means to detect changes in brain PG mass under both basal and pathological conditions and demonstrates the importance of sample preparation in this process.

We examined the ability of erucic acid (22:1n-9) to cross the blood-brain barrier (BBB) by infusing [14–14C]22:1n-9 (170 μCi/kg, iv and icv) into awake, male rats. [1-14C]arachidonic acid (20:4n-6) [intravenous (i.v.)] was the positive control. After i.v. infusion, 0.011% of the plasma [14-14C]22:1n-9 was extracted by the brain, compared with 0.055% of the plasma [1-14C]20:4n-6. The [14-14C]22:1n-9 was extensively β-oxidized (60%), compared with 30% for [1-14C]20:4n-6. Although 20:4n-6 was targeted primarily to phospholipid pools, 22:1n-9 was targeted to cholesteryl esters, triglycerides, and phospholipids. When [14-14C]22:1n-9 was infused directly into the fourth ventricle of the brain [intracerebroventricular (i.c.v.)] for 7 days, 60% of the tracer entered the phospholipid pools, similar to the distribution observed for [1-14C]20:4n-6. This demonstrates plasticity in the ability of the brain to esterify 22:1n-9 in an exposure-dependent manner. In i.v. and i.c.v. infused rats, a significant amount of tracer found in the phospholipid pools underwent sequential rounds of chain shortening and was found as [12-14C]20:1n-9 and [10-14C]oleic acid. These results demonstrate for the first time that intact 22:1n-9 crosses the BBB, is incorporated into specific lipid pools, and is chain-shortened.

We report an extensively modified method for the extraction, solid-phase purification, and HPLC analysis of long-chain acyl-CoAs from tissues. Tissue samples were homogenized in a glass homogenizer in KH2PO4 buffer (100 mM, pH 4.9) and again after the addition of 2-propanol. Acyl-CoAs were then extracted from the homogenate with acetonitrile (ACN). The acyl-CoAs in the extract were bound to an oligonucleotide purification column and eluted using 2-propanol. This eluent was concentrated and then loaded onto a C-18 column and eluted using a binary gradient system in which solvent A was KH2PO4 (75 mM, pH 4.9) and solvent B was ACN containing 600 mM glacial acetic acid. Initial flow rate was 0.5 or 0.25 ml/min depending upon the tissue used. The HPLC eluent was monitoring at 260 nm. Our modifications increased the recovery of the extraction procedure to 70–80%, depending upon tissue, with high reproducibility and significantly improved separation of the most common unsaturated and saturated acyl-CoAs. We also report, for the first time, the mass (nanomoles per gram wet weight) of the most common polyunsaturated acyl-CoAs in rat heart, kidney, and muscle tissues.The modifications and high recovery permit the use of tissue samples of less than 100 mg, making this method useful for the analysis of small tissue amounts associated with mice.

The rates of synthesis, turnover, and half-lives were determined for brain microsomal ether phospholipids in the awake adult unanesthetized rat. A multicompartmental kinetic model of phospholipid metabolism, based on known pathways of synthesis, was applied to data generated by a 5 min intravenous infusion of [1,1-3H]hexadecanol. At 2 h post-infusion, 29%, 33%, and 31% of the total labeled brain phospholipid was found in the 1-O-alkyl-2-acyl-sn-glycero-3-phosphate, ethanolamine, and choline ether phospholipid fractions, respectively. Autoradiography and membrane fractionation showed that 3% of the net incorporated radiotracer was in myelin at 2 h, compared to 97% in gray matter microsomal and synaptosomal fractions. Based on evidence that ether phospholipid synthesis occurs in the microsomal membrane fraction, we calculated the synthesis rates of plasmanylcholine, plasmanylethanolamine, plasmenylethanolamine, and plasmenylcholine equal to 1.2, 9.3, 27.6, and 21.5 nmol·g−1·min−1, respectively. Therefore, 8% of the total brain ether phospholipids have half-lives of about 36.5, 26.7, 23.1, and 15.1 min, respectively. Furthermore, we clearly demonstrate that there are at least two pools of ether phospholipids in the adult rat brain. One is the static myelin pool with a slow rate of tracer incorporation and the other is a dynamic pool found in gray matter. The short half-lives of microsomal ether phospholipids and the rapid transfer to synaptosomes are consistent with evidence of the marked involvement of these lipids in brain signal transduction and synaptic function. —Rosenberger, T. A., J. Oki, A. D. Purdon, S. I. Rapoport, and E. J. Murphy. Rapid synthesis and turnover of brain microsomal ether phospholipids in the adult rat. J. Lipid Res. 2002. 43: 59–68.

The effects sterol carrier protein-2 (SCP-2) expression on L-cell phospholipid levels and fatty acyl composition was assessed using L-cells transfected with the murine cDNA encoding for either the 15 kDa proSCP-2 or 13.2 kDa SCP-2. Expression of these proteins reduced total phospholipid mass (nmol/mg protein) by 24% and reduced the cholesterol to phospholipid ratio 60 and 28%, respectively. In 15 kDa proSCP-2 expressing cells, individual phospholipid class masses, excluding sphingomyelin (CerPCho), were reduced as follows: phosphatidylinositol (PtdIns) and phosphatidylserine (PtdSer) >> ethanolamine glycerophospholipid (EtnGpl) > choline glycerophospholipid (ChoGpl). Furthermore, ethanolamine plasmalogen mass was decreased 25%, while choline plasmalogen mass was elevated 30% in 15 kDa proSCP-2 expressing cells. In 13.2 kDa SCP-2 expressing cells, phospholipid class mass was decreased as follows: PtdIns and PtdSer >> ChoGpl. These changes in phospholipid mass resulted in altered cellular phospholipid composition. Expression of either protein differentially altered the type of fatty acid esterified onto the phospholipids. These effects included a greater proportion of polyunsaturated fatty acids and a reduction in saturated fatty acids, although 15 kDa proSCP-2 expression had a more robust effect on these parameters than did 13.2 kDa SCP-2 expression. In summary, expression of SCP-2 reduced individual phospholipid class mass, except for CerPCho, and altered the fatty acid composition of each phospholipid class examined. These results clearly demonstrate that SCP-2 expression altered basal phospholipid levels, suggesting that SCP-2 can alter the function of endoplasmic reticulum phospholipid synthetic enzymes.—Murphy, E. J., T. Stiles, and F. Schroeder. Sterol carrier protein-2 expression alters phospholipid content and fatty acyl composition in L-cell fibroblasts. J. Lipid Res. 2000. 41: 788–796.