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320 results on '"Errichetti, E."'

1. Real-World Experience of Bimekizumab in an Elderly Patients Cohort with Plaque-Type Psoriasis: A 24-Week Retrospective Study

Author

Fratton Z, Maione V, Bighetti S, Bettolini L, Arisi M, Stinco G, and Errichetti E

Subjects
Dermatology, RL1-803
Abstract

Zeno Fratton,1 Vincenzo Maione,2 Stefano Bighetti,2 Luca Bettolini,2 Mariachiara Arisi,2 Giuseppe Stinco,1 Enzo Errichetti1 1Department of Medicine, Institute of Dermatology, University of Udine, Udine, Italy; 2Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, ItalyCorrespondence: Enzo Errichetti, Institute of Dermatology, Department of Medicine, University of Udine, Piazzale Santa Maria della Misericordia, 15, Udine, 33100, Italy, Tel +39 0432559822, Email enzo.errichetti@uniud.it

Published
2024

2. Bimekizumab in Biologics-Refractory Psoriatic Arthritis: A Real-Life Analysis from a Combined Dermatology-Rheumatology Clinic

Author

Zabotti A, Cabas N, Giovannini I, Guella S, Cereser L, Zuiani C, Stinco G, Quartuccio L, and Errichetti E

Subjects
biologics, bimekizumab, psoriatic arthritis, refractory., Dermatology, RL1-803
Abstract

Alen Zabotti,1 Nicola Cabas,1 Ivan Giovannini,1 Silvia Guella,1 Lorenzo Cereser,2 Chiara Zuiani,2 Giuseppe Stinco,3 Luca Quartuccio,1 Enzo Errichetti3 1Department of Medical and Biological Sciences, Rheumatology Institute, Azienda sanitaria universitaria Friuli Centrale, Udine, Italy; 2Department of Medicine, Institute of Radiology, Azienda sanitaria universitaria Friuli Centrale, Udine, Italy; 3Department of Medical and Biological Sciences, Dermatology Institute, Azienda Sanitaria Universitaria Friuli Centrale, Udine, ItalyCorrespondence: Enzo Errichetti, Institute of Dermatology, Department of Medical Area, University of Udine, Piazzale Santa Maria della Misericordia, 15, Udine, 33100, Italy, Tel +39 0432559822, Email enzoerri@yahoo.it

Published
2024

3. Trichoscopic Features of Scalp Discoid Lupus Erythematosus versus Lichen Planopilaris: A Systematic Review

Author

Gowda SK, Errichetti E, Thakur V, Panda M, Dash S, Agarwal A, Sethy M, Ayyanar P, and Behera B

Subjects
scalp discoid lupus erythematosus, lichen planopilaris, trichoscopy, dermoscopy, primary cicatricial alopecia, Dermatology, RL1-803
Abstract

Shreya K Gowda,1 Enzo Errichetti,2 Vishal Thakur,1 Maitreyee Panda,3 Siddhartha Dash,4 Akash Agarwal,3 Madhusmita Sethy,5 Pavithra Ayyanar,5 Biswanath Behera1 1Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, OD, India; 2Institute of Dermatology, Department of Medicine, University of Udine, Udine, Italy; 3Department of Dermatology, IMS and SUM Hospital, Bhubaneswar, OD, India; 4Department of Dermatology, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, OD, India; 5Department of Pathology, All India Institute of Medical Sciences, Bhubaneswar, OD, IndiaCorrespondence: Biswanath Behera, Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, 751019, India, Email biswanathbehera61@gmail.comIntroduction: Lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) are primary scarring alopecias that pose diagnostic challenges clinically, where trichoscopy features may provide benefit in delineating these two cicatricial alopecia, and also helps in assessing the evolution and therapeutic response. To date, there are few reviews on dermoscopic findings in differentiating these two alopecias.Methods: A systematic literature review was conducted using the PubMed and Google Scholar databases. The search terms included for scalp DLE were ‘lupus’ OR ‘discoid lupus’ OR “scalp lupus” and for scalp LPP were “lichen planopilaris” OR “scalp follicular lichen planus” OR “lichen planus follicularis” and were combined with “dermoscopy” OR “dermatoscopy” OR “videodermoscopy” OR “video dermatoscopy” OR “trichoscopy”. The differences in the prevalence of dermoscopic features in scalp DLE and LPP were calculated using the Chi-square test.Results: Of 52 articles, 36 (17 LPP, 19 DLE) were eligible for quantitative analysis. We found predominant peripilar tubular casts and perifollicular erythema with the presence of arborizing vessels in the vicinity of these changes, indicating early LPP. In contrast, follicular red dots, speckled brown pigmentation, and hair diameter variability indicated active DLE. Shiny white areas were common in both the groups in late stages. The target pattern of distribution of blue-grey dots, milky red areas, and irregular white fibrotic dots were seen in LPP, and pink-white background, follicular plugs, perifollicular and interfollicular scale, rosettes, chrysalides, and red spider on yellow dots were detected in DLE. Features such as yellow dots and blue-grey structureless areas were nonspecific and did not have a major role in differentiating DLE from LPP.Conclusion: This article provides a comprehensive review of the literature and delineates the trichoscopic differences and peculiarities of scalp DLE and LPP, including the correlation of dermoscopic features with histopathological findings.Keywords: scalp discoid lupus erythematosus, lichen planopilaris, trichoscopy, dermoscopy, primary cicatricial alopecia

Published
2024

4. Dermoscopy of Primary Localized Cutaneous Nodular Amyloidosis

Author

Pulgarin LM, De Pellegrin A, Stinco G, and Errichetti E

Subjects
amyloidosis, dermoscopy, diagnosis, differential diagnosis., Dermatology, RL1-803
Abstract

Laura Manuela Pulgarin,1 Alessandro De Pellegrin,2 Giuseppe Stinco,3 Enzo Errichetti3 1Department of Dermatology, Universidad del Valle, Cali, Colombia; 2Department of Pathology, Udine “S. Maria della Misericordia” University Hospital, Udine, Italy; 3Institute of Dermatology, Department of Medicine, University of Udine, Udine, ItalyCorrespondence: Enzo Errichetti, Institute of Dermatology, Department of Medical Area, University of Udine, Piazzale Santa Maria della Misericordia, 15, Udine, 33100, Italy, Tel +39 0432559822, Email enzoerri@yahoo.it

Published
2024

5. The new Italian SIDAPA Baseline Series for patch testing (2023): an update according to the new regulatory pathway for contact allergens

Author

Stingeni, L, Bianchi, L, Caroppo, E, Belloni Fortina, A, Caroppo, F, Corazza, M, Borghi, A, Gallo, R, Trave, I, Ferrucci, S, Beretta, A, Guarneri, F, Martina, E, Napolitano, M, de Lucia, M, Patruno, C, Bennardo, L, Romita, P, Foti, C, Tramontana, M, Marietti, R, Argenziano, G, Hansel, K, Abategiovanni, L, Albertazzi, D, Ali Biglu Marash, S, Amendolagine, G, Angelini, G, Annunziata, A, Assalve, D, Ayala, F, Babino, G, Barruscotti, S, Battista, T, Berta, M, Biondi, F, Boccaletti, V, Bonamonte, D, Bruni, F, Buffon, R, Caccavale, S, Calabrese, L, Calzavara Pinton, P, Camela, E, Carugno, A, Casciola, G, Cecchini, E, Cristaudo, A, D'Agostino, M, Damiani, G, Danese, P, Dattola, A, de Salvo, V, Errichetti, E, Esposito, G, Esposito, M, Fantini, C, Fontana, E, Fornaro, L, Frasin, L, Galeotti, T, Gasparini, G, Genco, L, Gravante, M, Guastaferro, D, Guerrasio, G, Guerriero, L, Lauro, W, Lucagnano, G, Malatesta, N, Mandel, V, Marano, L, Marino, V, Martora, F, Menna, L, Miano, C, Miccio, L, Michelerio, A, Milanesi, N, Monfrecola, G, Motolese, A, Nocerino, M, Noto, M, Ornielli, M, Pacifico, A, Papini, M, Pasolini, G, Penchini, L, Perazzolli, G, Peserico, A, Piccolo, V, Pigatto, P, Potestio, L, Pugliese, A, Recalcati, S, Rivetti, N, Rossi, M, Russo, F, Russo, T, Schena, D, Sensini, C, Tesauri, D, Tomassini, G, Ventura, V, Venturini, M, Vezzoli, P, Vincenzi, C, Stingeni L., Bianchi L., Caroppo E. S., Belloni Fortina A., Caroppo F., Corazza M., Borghi A., Gallo R., Trave I., Ferrucci S. M., Beretta A., Guarneri F., Martina E., Napolitano M., de Lucia M., Patruno C., Bennardo L., Romita P., Foti C., Tramontana M., Marietti R., Argenziano G., Hansel K., Abategiovanni L., Albertazzi D., Ali Biglu Marash S., Amendolagine G., Angelini G., Annunziata A., Assalve D., Ayala F., Babino G., Barruscotti S., Battista T., Berta M., Biondi F., Boccaletti V., Bonamonte D., Bruni F., Buffon R., Caccavale S., Calabrese L., Calzavara Pinton P., Camela E., Carugno A., Casciola G., Cecchini E., Cristaudo A., D'Agostino M., Damiani G., Danese P., Dattola A., de Salvo V., Errichetti E., Esposito G., Esposito M., Fantini C., Fontana E., Fornaro L., Frasin L. A., Galeotti T., Gasparini G., Genco L., Gravante M., Guastaferro D., Guerrasio G., Guerriero L., Lauro W., Lucagnano G., Malatesta N., Mandel V. D., Marano L., Marino V., Martora F., Menna L., Miano C., Miccio L., Michelerio A., Milanesi N., Monfrecola G., Motolese A., Nocerino M., Noto M., Ornielli M., Pacifico A., Papini M., Pasolini G., Penchini L., Perazzolli G., Peserico A., Piccolo V., Pigatto P., Potestio L., Pugliese A., Recalcati S., Rivetti N., Rossi M., Russo F., Russo T., Schena D., Sensini C., Tesauri D., Tomassini G. M., Ventura V., Venturini M., Vezzoli P., Vincenzi C., Stingeni, L, Bianchi, L, Caroppo, E, Belloni Fortina, A, Caroppo, F, Corazza, M, Borghi, A, Gallo, R, Trave, I, Ferrucci, S, Beretta, A, Guarneri, F, Martina, E, Napolitano, M, de Lucia, M, Patruno, C, Bennardo, L, Romita, P, Foti, C, Tramontana, M, Marietti, R, Argenziano, G, Hansel, K, Abategiovanni, L, Albertazzi, D, Ali Biglu Marash, S, Amendolagine, G, Angelini, G, Annunziata, A, Assalve, D, Ayala, F, Babino, G, Barruscotti, S, Battista, T, Berta, M, Biondi, F, Boccaletti, V, Bonamonte, D, Bruni, F, Buffon, R, Caccavale, S, Calabrese, L, Calzavara Pinton, P, Camela, E, Carugno, A, Casciola, G, Cecchini, E, Cristaudo, A, D'Agostino, M, Damiani, G, Danese, P, Dattola, A, de Salvo, V, Errichetti, E, Esposito, G, Esposito, M, Fantini, C, Fontana, E, Fornaro, L, Frasin, L, Galeotti, T, Gasparini, G, Genco, L, Gravante, M, Guastaferro, D, Guerrasio, G, Guerriero, L, Lauro, W, Lucagnano, G, Malatesta, N, Mandel, V, Marano, L, Marino, V, Martora, F, Menna, L, Miano, C, Miccio, L, Michelerio, A, Milanesi, N, Monfrecola, G, Motolese, A, Nocerino, M, Noto, M, Ornielli, M, Pacifico, A, Papini, M, Pasolini, G, Penchini, L, Perazzolli, G, Peserico, A, Piccolo, V, Pigatto, P, Potestio, L, Pugliese, A, Recalcati, S, Rivetti, N, Rossi, M, Russo, F, Russo, T, Schena, D, Sensini, C, Tesauri, D, Tomassini, G, Ventura, V, Venturini, M, Vezzoli, P, Vincenzi, C, Stingeni L., Bianchi L., Caroppo E. S., Belloni Fortina A., Caroppo F., Corazza M., Borghi A., Gallo R., Trave I., Ferrucci S. M., Beretta A., Guarneri F., Martina E., Napolitano M., de Lucia M., Patruno C., Bennardo L., Romita P., Foti C., Tramontana M., Marietti R., Argenziano G., Hansel K., Abategiovanni L., Albertazzi D., Ali Biglu Marash S., Amendolagine G., Angelini G., Annunziata A., Assalve D., Ayala F., Babino G., Barruscotti S., Battista T., Berta M., Biondi F., Boccaletti V., Bonamonte D., Bruni F., Buffon R., Caccavale S., Calabrese L., Calzavara Pinton P., Camela E., Carugno A., Casciola G., Cecchini E., Cristaudo A., D'Agostino M., Damiani G., Danese P., Dattola A., de Salvo V., Errichetti E., Esposito G., Esposito M., Fantini C., Fontana E., Fornaro L., Frasin L. A., Galeotti T., Gasparini G., Genco L., Gravante M., Guastaferro D., Guerrasio G., Guerriero L., Lauro W., Lucagnano G., Malatesta N., Mandel V. D., Marano L., Marino V., Martora F., Menna L., Miano C., Miccio L., Michelerio A., Milanesi N., Monfrecola G., Motolese A., Nocerino M., Noto M., Ornielli M., Pacifico A., Papini M., Pasolini G., Penchini L., Perazzolli G., Peserico A., Piccolo V., Pigatto P., Potestio L., Pugliese A., Recalcati S., Rivetti N., Rossi M., Russo F., Russo T., Schena D., Sensini C., Tesauri D., Tomassini G. M., Ventura V., Venturini M., Vezzoli P., and Vincenzi C.

Abstract

Allergic contact dermatitis (ACD) is a common inflammatory skin disease caused by delayed hypersensitivity to chemical and biotic contact allergens. ACD significantly affects the patients' quality of life negatively impacting both occupational and non-occupational settings. Patch testing is the gold standard diagnostic in vivo test to precise the ACD etiology and to correctly perform prevention. According to the Italian Medicines Agency (AIFA) legislative decree no. 178 of 29th May 1991, allergens are defined as medicines and therefore they are subject to strict regulation. In 2017, AIFA (decree no. 2130/2017) started a procedure to regulate contact allergens on the Italian market and actually the contact allergens temporarily authorized are reported in AIFA decree no. 98/2022, valid until November 2023. The availability on the market of contact allergens to diagnose ACD and continuous updating on the basis of new epidemiological trends are mandatory, jointly with the continuous update of the baseline and integrative series for patch testing. For this reason, the scientific community represented in Italy by the Skin Allergies Study Group of SIDeMaST (Italian Society of Dermatology and Venereology) and SIDAPA (Italian Society of Allergological, Occupational and Environmental Dermatology) are constantly working, in close relationship with the European scientific communities with large expertise in this important sector of the modern Dermatology. Herein, we report the setting up of regulatory legislation by AIFA and the new Italian Adult Baseline Series for patch testing.

Published
2024

6. Efficacy and Safety of bimekizumab in elderly patients: real-world multicenter retrospective study - IL PSO (Italian Landscape Psoriasis)

Author

Orsini, D, Megna, M, Assorgi, C, Balato, A, Balestri, R, Bernardini, N, Bettacchi, A, Bianchelli, T, Bianchi, L, Buggiani, G, Burlando, M, Brunasso, A, Caldarola, G, Cameli, N, Campanati, A, Campione, E, Carugno, A, Chersi, K, Conti, A, Costanzo, A, Cozzani, E, Cuccia, A, D'Amico, D, Dal Bello, G, Dall'Olio, E, Dapavo, P, De Simone, C, Di Brizzi, E, Di Cesare, A, Dini, V, Esposito, M, Errichetti, E, Fargnoli, M, Fiorella, C, Foti, A, Fratton, Z, Gaiani, F, Gisondi, P, Giuffrida, R, Giunta, A, Guarneri, C, Legori, A, Loconsole, F, Malagoli, P, Narcisi, A, Paolinelli, M, Potestio, L, Prignano, F, Rech, G, Rossi, A, Skroza, N, Trovato, F, Venturini, M, Richetta, A, Pellacani, G, Dattola, A, Brunasso, Amg, Dall'Olio, E G, Di Brizzi, E V, Fargnoli, M C, Fiorella, C S, Gaiani, F M, Richetta, A G, Orsini, D, Megna, M, Assorgi, C, Balato, A, Balestri, R, Bernardini, N, Bettacchi, A, Bianchelli, T, Bianchi, L, Buggiani, G, Burlando, M, Brunasso, A, Caldarola, G, Cameli, N, Campanati, A, Campione, E, Carugno, A, Chersi, K, Conti, A, Costanzo, A, Cozzani, E, Cuccia, A, D'Amico, D, Dal Bello, G, Dall'Olio, E, Dapavo, P, De Simone, C, Di Brizzi, E, Di Cesare, A, Dini, V, Esposito, M, Errichetti, E, Fargnoli, M, Fiorella, C, Foti, A, Fratton, Z, Gaiani, F, Gisondi, P, Giuffrida, R, Giunta, A, Guarneri, C, Legori, A, Loconsole, F, Malagoli, P, Narcisi, A, Paolinelli, M, Potestio, L, Prignano, F, Rech, G, Rossi, A, Skroza, N, Trovato, F, Venturini, M, Richetta, A, Pellacani, G, Dattola, A, Brunasso, Amg, Dall'Olio, E G, Di Brizzi, E V, Fargnoli, M C, Fiorella, C S, Gaiani, F M, and Richetta, A G

Abstract

Purpose of the article: The aim of this multicenter observational study is to report data from real world on the use of bimekizumab in patients aged ≥ 65 years with moderate-to-severe plaque psoriasis. Elderly patients are poorly represented in clinical trials on bimekizumab for plaque psoriasis, and real-world studies are important to guide clinical choices. Materials and methods: A retrospective multicenter study was conducted in 33 dermatological outpatient clinics in Italy. Patients aged ≥ 65 years, with moderate-to-severe plaque psoriasis and treated with bimekizumab were enrolled. No exclusion criteria were applied. Bimekizumab was administered following the Italian Guidelines for the management of plaque psoriasis and according to the summary of product characteristics, in adult patients who were candidates for systemic treatments. Overall, 98 subjects were included, and received bimekizumab up to week 36. Clinical and demographic data were collected before the initiation of treatment with bimekizumab. At baseline and each dermatological examination (4, 16, and 36 weeks), clinical outcomes were measured by the following parameters: (1) PASI score; (2) site-specific (scalp, palmoplantar, genital, nail) Psoriasis Global Assessment (PGA). At each visit, the occurrence of any adverse events (AEs) was recorded, including serious AEs and AEs leading to bimekizumab discontinuation. Results: The mean PASI score was 16.6 ± 9.4 at baseline and significantly decreased to 4.3 ± 5.2 after 4 weeks (p < 0.001), and 1.1 ± 1.7 after 16 week (p < 0.001). This level of improvement was maintained after 36 weeks (p < 0.001). PASI ≤2 was recorded in 36 (36.7%) at week 4, 68% and 69.4% at week 16 and 36, respectively. By week 16, 86/98 (87.8%) patients reached PASI75, 71/98 (72.4%) obtained PASI90, and 52/98 (53.1%) PASI100. Binary logistic regression tests showed a significant association of PASI100 by week 4 with lower PASI at baseline. PASI 100 at 16 or 36 weeks was not

Published
2024

7. Therapeutic management of classic lichen planopilaris: a systematic review

Author

Errichetti E, Figini M, Croatto M, and Stinco G

Subjects
Lichen planopilaris, management, therapy, treatment., Dermatology, RL1-803
Abstract

Enzo Errichetti, Matteo Figini, Margherita Croatto, Giuseppe Stinco Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy Abstract: Several treatment strategies have been proposed in classic lichen planopilaris (LPP), although no gold standard therapeutic approach has been recognized so far due to the variable and, sometimes, contradictory results reported in the literature, as well as due to the lack of guidelines and randomized controlled trials. In the present review, we sought to provide an updated overview on the treatment of classic LPP by analyzing the level of evidence of published studies, also proposing a possible therapeutic strategy according to the findings highlighted in this systematic review. Keywords: lichen planopilaris, management, therapy, treatment

Published
2018

8. Long-term proactive management of psoriasis with calcipotriol and betamethasone dipropionate foam: an Italian consensus through a combined nominal group technique and Delphi approach

Author

De Simone, C, Dapavo, P, Malagoli, P, Martella, A, Campanati, A, Campione, E, Errichetti, E, Franchi, C, Gambardella, A, Megna, M, Osti, F, Ribero, S, Zagni, G, Calzavara-Pinton, P, Fabbrocini, G, Amoruso, G, Baglieri, F, Biamonte, A, Bianchelli, T, Bigi, L, Bortoli, J, Brunetti, B, Buligan, C, Cagni, E, Calderoni, O, Caputo, A, Carrera, C, Carugno, A, Chersi, K, Cicchelli, S, De Natale, F, Di Maria, D, Ferrari, A, Fogli, E, Forconi, R, Galeazzi, A, Giovannini, A, Giura, M, Iuculano, M, Lazzaretti, G, Leporati, C, Magnanini, M, Marconi, B, Maruccia, A, Miglietta, R, Minuti, A, Mocci, L, Modica, S, Narcisi, A, Odorici, G, Pazzaglia, M, Peila, R, Pertusi, G, Pezza, M, Pezzullo, E, Puccia, N, Raulo, U, Rossi, M, Rusignuolo, S, Sapienza, G, Savarese, C, Scalisi, M, Strippoli, D, Stroppiana, E, Tiberio, R, Trischitta, A, Tucci, M, Vaira, F, Verrone, A, Villa, L, Zagni, F, Zoccali, A, De Simone C., Dapavo P., Malagoli P., Martella A., Campanati A., Campione E., Errichetti E., Franchi C., Gambardella A., Megna M., Osti F., Ribero S., Zagni G., Calzavara-Pinton P., Fabbrocini G., Amoruso G. F., Baglieri F., Biamonte A. S., Bianchelli T., Bigi L., Bortoli J., Brunetti B., Buligan C., Cagni E., Calderoni O., Caputo A., Carrera C. G., Carugno A., Chersi K., Cicchelli S., De Natale F., Di Maria D., Ferrari A. S., Fogli E., Forconi R., Galeazzi A., Giovannini A., Giura M. T., Iuculano M., Lazzaretti G., Leporati C., Magnanini M., Marconi B., Maruccia A., Miglietta R., Minuti A., Mocci L., Modica S., Narcisi A., Odorici G., Pazzaglia M., Peila R., Pertusi G., Pezza M., Pezzullo E., Puccia N., Raulo U., Rossi M., Rusignuolo S., Sapienza G., Savarese C., Scalisi M., Strippoli D., Stroppiana E., Tiberio R., Trischitta A., Tucci M. G., Vaira F., Verrone A., Villa L., Zagni F., Zoccali A., De Simone, C, Dapavo, P, Malagoli, P, Martella, A, Campanati, A, Campione, E, Errichetti, E, Franchi, C, Gambardella, A, Megna, M, Osti, F, Ribero, S, Zagni, G, Calzavara-Pinton, P, Fabbrocini, G, Amoruso, G, Baglieri, F, Biamonte, A, Bianchelli, T, Bigi, L, Bortoli, J, Brunetti, B, Buligan, C, Cagni, E, Calderoni, O, Caputo, A, Carrera, C, Carugno, A, Chersi, K, Cicchelli, S, De Natale, F, Di Maria, D, Ferrari, A, Fogli, E, Forconi, R, Galeazzi, A, Giovannini, A, Giura, M, Iuculano, M, Lazzaretti, G, Leporati, C, Magnanini, M, Marconi, B, Maruccia, A, Miglietta, R, Minuti, A, Mocci, L, Modica, S, Narcisi, A, Odorici, G, Pazzaglia, M, Peila, R, Pertusi, G, Pezza, M, Pezzullo, E, Puccia, N, Raulo, U, Rossi, M, Rusignuolo, S, Sapienza, G, Savarese, C, Scalisi, M, Strippoli, D, Stroppiana, E, Tiberio, R, Trischitta, A, Tucci, M, Vaira, F, Verrone, A, Villa, L, Zagni, F, Zoccali, A, De Simone C., Dapavo P., Malagoli P., Martella A., Campanati A., Campione E., Errichetti E., Franchi C., Gambardella A., Megna M., Osti F., Ribero S., Zagni G., Calzavara-Pinton P., Fabbrocini G., Amoruso G. F., Baglieri F., Biamonte A. S., Bianchelli T., Bigi L., Bortoli J., Brunetti B., Buligan C., Cagni E., Calderoni O., Caputo A., Carrera C. G., Carugno A., Chersi K., Cicchelli S., De Natale F., Di Maria D., Ferrari A. S., Fogli E., Forconi R., Galeazzi A., Giovannini A., Giura M. T., Iuculano M., Lazzaretti G., Leporati C., Magnanini M., Marconi B., Maruccia A., Miglietta R., Minuti A., Mocci L., Modica S., Narcisi A., Odorici G., Pazzaglia M., Peila R., Pertusi G., Pezza M., Pezzullo E., Puccia N., Raulo U., Rossi M., Rusignuolo S., Sapienza G., Savarese C., Scalisi M., Strippoli D., Stroppiana E., Tiberio R., Trischitta A., Tucci M. G., Vaira F., Verrone A., Villa L., Zagni F., and Zoccali A.

Abstract

Background: Although long-term management of psoriasis is paramount, this approach is challenging in clinical practice. In the recent PSO-LONG trial, a fixed-dose combination of betamethasone dipropionate (BD) and calcipotriol (Cal) foam applied twice a week on non-consecutive days for 52 weeks (proactive treatment) reduced the risk of relapse. However, the role of Cal/BD foam in the long-term management of psoriasis needs further clarifications. The ProActive Management (PAM) program, a nationwide Italian project, aims at reaching a consensus on the role of proactive management of psoriasis. Methods: A steering committee generated some statements through the nominal group technique (NGT). The statements were voted by an expert panel in an adapted Delphi voting process. Results: Eighteen statements were proposed, and the majority of them (14/18) reached a consensus during the Delphi voting. The need to provide long-term proactive topical treatment to reduce the risk of relapse for the treatment of challenging diseases sites or in patients where phototherapy or systemic therapies are contraindicated/ineffective was widely recognized. A consensus was reached about the possibility to associate the proactive treatment with systemic and biological therapies, without the need for dose intensification, thus favoring a prolonged remission. Moreover, the proactive treatment was recognized as more effective than weekend therapy in increasing time free from relapses. Approaches to improve adherence, on the other hand, need further investigation. Conclusions: The inclusion in guidelines of a proactive strategy among the effective treatment options will be a fundamental step in the evolution of a mild-moderate psoriasis therapeutic approach.

Published
2022

9. OP0062 EULAR POINTS TO CONSIDER FOR THE DEFINITION OF CLINICAL AND IMAGING FEATURES SUSPICIOUS FOR PROGRESSION TO PSORIATIC ARTHRITIS

Author

Zabotti, A., primary, De Marco, G., additional, Gossec, L., additional, Baraliakos, X., additional, Aletaha, D., additional, Iagnocco, A., additional, Gisondi, P., additional, Balint, P., additional, Bertheussen, H., additional, Boehncke, W. H., additional, Damjanov, N., additional, De Wit, M., additional, Errichetti, E., additional, Marzo-Ortega, H., additional, Protopopov, M., additional, Puig, L., additional, Queiró Silva, R., additional, Ruscitti, P., additional, Savage, L., additional, Schett, G., additional, Siebert, S., additional, Stamm, T., additional, Studenic, P., additional, Tinazzi, I., additional, Van den Bosch, F., additional, Van der Helm – van Mil, A., additional, Watad, A., additional, Smolen, J. S., additional, and Mcgonagle, D., additional

Published
2023
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10. Brodalumab for the Treatment of Moderate-to-Severe Psoriasis: An Expert Delphi Consensus Statement

Author

Fargnoli, Maria Concetta, Bardazzi, F., Bianchi, L., Dapavo, P., Fabbrocini, G., Gisondi, P., Micali, G., Offidani, A. M., Pellacani, G., Skroza, N., Angileri, R. G., Burlando, M., Campanati, A., Carrera, C. G., Chiricozzi, Andrea, Conti, A., Simone, C. D., Di Lernia, V., Errichetti, E., Galluzzo, M., Guarneri, C., Lasagni, C., Lembo, S., Loconsole, F., Megna, M., Musumeci, M. L., Prignano, F., Richetta, A. G., Trovato, E., Venturini, M., Peris, Ketty, Pinton, P. C., Fargnoli M. C., Chiricozzi A. (ORCID:0000-0002-6739-0387), Peris K. (ORCID:0000-0002-5237-0463), Fargnoli, Maria Concetta, Bardazzi, F., Bianchi, L., Dapavo, P., Fabbrocini, G., Gisondi, P., Micali, G., Offidani, A. M., Pellacani, G., Skroza, N., Angileri, R. G., Burlando, M., Campanati, A., Carrera, C. G., Chiricozzi, Andrea, Conti, A., Simone, C. D., Di Lernia, V., Errichetti, E., Galluzzo, M., Guarneri, C., Lasagni, C., Lembo, S., Loconsole, F., Megna, M., Musumeci, M. L., Prignano, F., Richetta, A. G., Trovato, E., Venturini, M., Peris, Ketty, Pinton, P. C., Fargnoli M. C., Chiricozzi A. (ORCID:0000-0002-6739-0387), and Peris K. (ORCID:0000-0002-5237-0463)

Abstract

Brodalumab is a recombinant, fully human immunoglobulin IgG2 monoclonal antibody specifically targeted against interleukin-17RA that has been approved for the treatment of moderate-to-severe psoriasis in Europe. We developed a Delphi consensus document focused on brodalumab for the treatment of moderate-to-severe psoriasis. Based on published literature and their clinical experience a steering committee drafted 17 statements covering 7 domains specific to the treatment of moderate-to-severe psoriasis with brodalumab. A panel of 32 Italian dermatologists indicated their level of agreement using a 5-point Likert scale (from 1 = “strongly disagree” to 5 = “strongly agree”) using an online modified Delphi method. After the first round of voting (32 participants), positive consensus was reached for 15/17 (88.2%) of the proposed statements. Following a face-to-face virtual meeting, the steering committee decided that 5 statements would form “main principles” and 10 statements formed the final list. After a second round of voting, consensus was reached in 4/5 (80%) of the main principles and 8/10 (80%) for consensus statements. The final list of 5 main principles and 10 consensus statements identify key indications specific to the use of brodalumab in the treatment of moderate-to-severe psoriasis in Italy. These statements aid dermatologists in the management of patients with moderate-to-severe psoriasis.

Published
2023

11. A 52-week update of a multicentre Italian real-world experience on effectiveness and safety of dupilumab in adolescents with moderate-to-severe atopic dermatitis

Author

Stingeni, L., Bianchi, L., Antonelli, E., Caroppo, E. S., Ferrucci, S. M., Gurioli, C., Ortoncelli, M., Fabbrocini, G., Nettis, E., Schena, D., Napolitano, M., Gola, M., Bonzano, L., Rossi, M., Belloni Fortina, A., Balato, A., Peris, Ketty, Foti, C., Guarneri, F., Romanelli, M., Patruno, C., Savoia, P., Esposito, M., Russo, F., Errichetti, E., Bianchelli, T., Pellacani, G., Feliciani, C., Offidani, A., Corazza, M., Micali, G., Milanesi, N., Malara, G., Chiricozzi, Andrea, Tramontana, M., Hansel, K., Buligan, C., Caroppo, F., Bello, G. D., Dastoli, S., Di Brizzi, E. V., Del Giudice, M. B. D. F., Diluvio, L., Fargnoli, Maria Concetta, Gelmetti, A., Giacchetti, A., Grieco, T., Iannone, M., Macchia, L., Marietti, R., Musumeci, M. L., Motolese, A., Neri, I., Radi, G., Ribero, S., Romita, P., Tavecchio, S., Tronconi, G., Veronese, F., Peris K. (ORCID:0000-0002-5237-0463), Chiricozzi A. (ORCID:0000-0002-6739-0387), Fargnoli M. C., Stingeni, L., Bianchi, L., Antonelli, E., Caroppo, E. S., Ferrucci, S. M., Gurioli, C., Ortoncelli, M., Fabbrocini, G., Nettis, E., Schena, D., Napolitano, M., Gola, M., Bonzano, L., Rossi, M., Belloni Fortina, A., Balato, A., Peris, Ketty, Foti, C., Guarneri, F., Romanelli, M., Patruno, C., Savoia, P., Esposito, M., Russo, F., Errichetti, E., Bianchelli, T., Pellacani, G., Feliciani, C., Offidani, A., Corazza, M., Micali, G., Milanesi, N., Malara, G., Chiricozzi, Andrea, Tramontana, M., Hansel, K., Buligan, C., Caroppo, F., Bello, G. D., Dastoli, S., Di Brizzi, E. V., Del Giudice, M. B. D. F., Diluvio, L., Fargnoli, Maria Concetta, Gelmetti, A., Giacchetti, A., Grieco, T., Iannone, M., Macchia, L., Marietti, R., Musumeci, M. L., Motolese, A., Neri, I., Radi, G., Ribero, S., Romita, P., Tavecchio, S., Tronconi, G., Veronese, F., Peris K. (ORCID:0000-0002-5237-0463), Chiricozzi A. (ORCID:0000-0002-6739-0387), and Fargnoli M. C.

Abstract

na

Published
2023

13. Moderate-to-severe atopic dermatitis in adolescents treated with dupilumab: A multicentre Italian real-world experience

Author

Stingeni, L., Bianchi, L., Antonelli, E., Caroppo, E. S., Ferrucci, S. M., Ortoncelli, M., Fabbrocini, G., Nettis, E., Schena, D., Napolitano, M., Gola, M., Bonzano, L., Rossi, M., Belloni Fortina, A., Balato, A., Peris, K., Foti, C., Guarneri, F., Romanelli, M., Patruno, C., Savoia, P., Fargnoli, M. C., Russo, F., Errichetti, E., Bianchelli, T., Pellacani, G., Feliciani, C., Offidani, A., Corazza, M., Micali, G., Milanesi, N., Malara, G., Chiricozzi, A., Tramontana, M., Hansel, K., Bini, V., Buligan, C., Caroppo, F., Dal Bello, G., Dastoli, S., Di Brizzi, E. V., De Felici Del Giudice, M. B., Diluvio, L., Esposito, M., Gelmetti, A., Giacchetti, A., Grieco, T., Iannone, M., Macchia, L., Marietti, R., Musumeci, M. L., Peccerillo, F., Pluchino, F., Radi, G., Ribero, S., Romita, P., Tavecchio, S., Tronconi, G., Veronese, F., Stingeni, L, Bianchi, L, Antonelli, E, Caroppo, E S, Ferrucci, S M, Ortoncelli, M, Fabbrocini, G, Nettis, E, Schena, D, Napolitano, M, Gola, M, Bonzano, L, Rossi, M, Belloni Fortina, A, Balato, A, Peris, K, Foti, C, Guarneri, F, Romanelli, M, Patruno, C, Savoia, P, Fargnoli, M C, Russo, F, Errichetti, E, Bianchelli, T, Pellacani, G, Feliciani, C, Offidani, A, Corazza, M, Micali, G, Milanesi, N, Malara, G, Chiricozzi, A, Tramontana, M, and Hansel, K

Subjects
SARS-CoV-2, Pruritus, Eczema, COVID-19, Dermatitis, Dermatology, Antibodies, Monoclonal, Humanized, Severity of Illness Index, Atopic, Antibodies, COVID-19 Drug Treatment, Dermatitis, Atopic, Treatment Outcome, Settore MED/35, Infectious Diseases, Double-Blind Method, Monoclonal, Humans, Prospective Studies, Settore MED/35 - MALATTIE CUTANEE E VENEREE, Pandemics, Humanized
Abstract

Background Moderate-to-severe atopic dermatitis (AD) in the adolescence is a high burden disease, and its treatment can be very challenging due to paucity of approved systemic drugs for this age and their side-effects. Dupilumab was recently approved for treatment of adolescent AD. Objectives A multicentre, prospective, real-world study on the effectiveness and safety of dupilumab in adolescents (aged from >= 12 to

Published
2022

15. Moderate-to-severe atopic dermatitis in adolescents treated with dupilumab: A multicentre Italian real-world experience

Author

Stingeni, L, Bianchi, L, Antonelli, E, Caroppo, E S, Ferrucci, S M, Ortoncelli, M, Fabbrocini, G, Nettis, E, Schena, D, Napolitano, M, Gola, M, Bonzano, L, Rossi, M, Belloni Fortina, A, Balato, A, Peris, Ketty, Foti, C, Guarneri, F, Romanelli, M, Patruno, C, Savoia, P, Fargnoli, M C, Russo, F, Errichetti, E, Bianchelli, T, Pellacani, G, Feliciani, C, Offidani, A, Corazza, M, Micali, G, Milanesi, N, Malara, G, Chiricozzi, Andrea, Tramontana, M, Hansel, K, Peris, K (ORCID:0000-0002-5237-0463), Chiricozzi, A (ORCID:0000-0002-6739-0387), Stingeni, L, Bianchi, L, Antonelli, E, Caroppo, E S, Ferrucci, S M, Ortoncelli, M, Fabbrocini, G, Nettis, E, Schena, D, Napolitano, M, Gola, M, Bonzano, L, Rossi, M, Belloni Fortina, A, Balato, A, Peris, Ketty, Foti, C, Guarneri, F, Romanelli, M, Patruno, C, Savoia, P, Fargnoli, M C, Russo, F, Errichetti, E, Bianchelli, T, Pellacani, G, Feliciani, C, Offidani, A, Corazza, M, Micali, G, Milanesi, N, Malara, G, Chiricozzi, Andrea, Tramontana, M, Hansel, K, Peris, K (ORCID:0000-0002-5237-0463), and Chiricozzi, A (ORCID:0000-0002-6739-0387)

Abstract

Background Moderate-to-severe atopic dermatitis (AD) in the adolescence is a high burden disease, and its treatment can be very challenging due to paucity of approved systemic drugs for this age and their side-effects. Dupilumab was recently approved for treatment of adolescent AD. Objectives A multicentre, prospective, real-world study on the effectiveness and safety of dupilumab in adolescents (aged from >= 12 to <18 years) with moderate-to-severe AD was conducted. The main AD clinical phenotypes were also examined. Methods Data of adolescents with moderate-to-severe AD treated with dupilumab at label dosage for 16 weeks were collected. Treatment outcome was assessed by EASI, NRS itch, NRS sleep loss and CDLQI scores at baseline and after 16 weeks of treatment. The clinical scores were also evaluated according to clinical phenotypes. Results One hundred and thirty-nine adolescents were enrolled in the study. Flexural eczema and head and neck eczema were the most frequent clinical phenotypes, followed by hand eczema and portrait-like dermatitis. Coexistence of more than 1 phenotype was documented in 126/139 (88.5%) adolescents. Three patients (2.1%) contracted asymptomatic SARS-CoV-2 infection and 1 of the discontinued dupilumab treatment before the target treatment period. A significant improvement in EASI, NRS itch, NRS sleep loss and CDLQI was observed after 16 weeks of treatment with dupilumab. This outcome was better than that observed in clinical trials. Dupilumab resulted effective in all AD phenotypes, especially in diffuse eczema. Twenty-eight (20.1%) patients reported adverse events, conjunctivitis and flushing being the most frequent. None of patients discontinued dupilumab due to adverse event. Conclusions Dupilumab in adolescent AD showed excellent effectiveness at week 16 with consistent improvement of all clinical scores. Moreover, dupilumab showed a good safety profile also in this COVID-19 pandemic era.

Published
2022

16. Dermoscopic spectrum of mycosis fungoides: a retrospective observational study by the International Dermoscopy Society

Author

Errichetti, E., primary, Apalla, Z., additional, Geller, S., additional, Sławińska, M., additional, Kyrgidis, A., additional, Kaminska‐Winciorek, G., additional, Jurakic Toncic, R., additional, Bobos, M., additional, Rados, J., additional, Ledic Drvar, D., additional, Ceovic, R., additional, Akay, B. N., additional, Piccolo, V., additional, Myskowski, P., additional, Vitiello, P., additional, Russo, T., additional, Argenziano, G., additional, Sokołowska‐Wojdyło, M., additional, Sobjanek, M., additional, Stojkovic‐Filipovic, J., additional, Longo, C., additional, Pellacani, G., additional, Stinco, G., additional, and Lallas, A., additional

Published
2022
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17. Clinical and dermatoscopic predictors of squamous cell carcinoma of the lips: a case-control, multicentric study

Author

Lallas, A. Martinez, G. Arceu, M. Kyrgidis, A. Liopyris, K. Brancaccio, G. Longo, C. Errichetti, E. Sgouros, D. and Papageorgiou, C. Fotiadou, C. Siskou, S. Manoli, S. M. and Sotiriou, E. Ioannides, D. Katoulis, A. Lazaridou, E. and Todorovska, V Argenziano, G. Apalla, Z.

Subjects
stomatognathic diseases
Abstract

Background Squamous cell carcinoma of the lip accounts for 20% of all oral carcinomas. Its diagnosis may be challenging because it clinically resembles actinic cheilitis and inflammatory lesions of the lips. Objectives To determine clinical and dermatoscopic predictors of squamous cell carcinoma of the lip vs. other lip lesions. Methods Multicentre retrospective morphological study, including histologically confirmed cases of squamous cell carcinoma of the lip and controls consisting of actinic cheilitis and inflammatory lesions of the lips. Clinical and dermatoscopic images were evaluated for the presence of predefined criteria. Crude and adjusted odds ratios and corresponding 95% confidence intervals were calculated by univariate and multivariate logistic regression respectively. Results A total of 177 lip lesions were evaluated, 107 (60.5%) were squamous cell carcinomas and 70 (39.5%) were controls. The most frequent dermatoscopic criteria of lip squamous cell carcinoma were scales (100%), white halos (87.3%) and ulceration (79.4%). The majority of squamous cell carcinomas displayed polymorphic vessels (60.8%), with linear (68.6%) and hairpin (67.6%) being the most frequent types. Multivariate logistic regression analysis showed that clinical predictors of lip squamous cell carcinoma were exophytic appearance and clinical hyperkeratosis, with 43-fold and 6-fold higher probability respectively. White clods and ulceration in dermoscopy presented a 6-fold and 4-fold increased risk for squamous cell carcinoma respectively. Conclusions A scaly lesion with exophytic growth, dermatoscopically displaying white clods, ulceration and linear and hairpin vessels is very likely a squamous cell carcinoma of the lip.

Published
2022

21. Transition phase towards psoriatic arthritis: Clinical and ultrasonographic characterisation of psoriatic arthralgia

Author

Zabotti, A, Mcgonagle, D, Giovannini, I, Errichetti, E, Zuliani, F, Zanetti, A, Tinazzi, I, De Lucia, O, Batticciotto, A, Idolazzi, L, Sakellariou, G, Zandonella Callegher, S, Sacco, S, Quartuccio, L, Iagnocco, A, De Vita, S, Zabotti A., McGonagle D. G., Giovannini I., Errichetti E., Zuliani F., Zanetti A., Tinazzi I., De Lucia O., Batticciotto A., Idolazzi L., Sakellariou G., Zandonella Callegher S., Sacco S., Quartuccio L., Iagnocco A., De Vita S., Zabotti, A, Mcgonagle, D, Giovannini, I, Errichetti, E, Zuliani, F, Zanetti, A, Tinazzi, I, De Lucia, O, Batticciotto, A, Idolazzi, L, Sakellariou, G, Zandonella Callegher, S, Sacco, S, Quartuccio, L, Iagnocco, A, De Vita, S, Zabotti A., McGonagle D. G., Giovannini I., Errichetti E., Zuliani F., Zanetti A., Tinazzi I., De Lucia O., Batticciotto A., Idolazzi L., Sakellariou G., Zandonella Callegher S., Sacco S., Quartuccio L., Iagnocco A., and De Vita S.

Abstract

Objective Non-specific musculoskeletal pain is common in subjects destined to develop psoriatic arthritis (PsA). We evaluated psoriatic patients with arthralgia (PsOAr) compared with psoriasis alone (PsO) and healthy controls (HCs) using ultrasonography (US) to investigate the anatomical basis for joint symptoms in PsOAr and the link between these imaging findings and subsequent PsA transition. Methods A cross-sectional prevalence analysis of clinical and US abnormalities (including inflammatory and structural lesions) in PsOAr (n=61), PsO (n=57) and HCs (n=57) was performed, with subsequent prospective follow-up for PsA development. Results Tenosynovitis was the only significant sonographic feature that differed between PsOAr and PsO (29.5% vs 5.3%, p<0.001), although synovitis and enthesitis were numerically more frequent in PsOAr. Five patients in PsOAr and one in PsO group developed PsA, with an incidence rate of 109.2/1000 person-years in PsOAr vs 13.4/1000 person-years in PsO (p=0.03). Visual Analogue Scale pain, Health Assessment Questionnaire, joint tenderness and US active enthesitis were baseline variables associated with PsA development. Conclusion Tenosynovitis was associated with arthralgia in subjects with psoriasis. Baseline US evidence of enthesitis was associated with clinical PsA development in the longitudinal analysis. These findings are relevant for enriching for subjects at risk of imminent PsA development.

Published
2019

22. Standardization of dermoscopic terminology and basic dermoscopic parameters to evaluate in general dermatology (non‐neoplastic dermatoses): an expert consensus on behalf of the International Dermoscopy Society

Author

Errichetti, E, Zalaudek, I, Kittler, H, Apalla, Z, Argenziano, G, Bakos, R, Blum, A, Braun, R P, Ioannides, D, Lacarrubba, F, Lazaridou, E, Longo, C, Micali, G, Moscarella, E, Paoli, J, Papageorgiou, C, Russo, T, Scope, A, Stinco, G, Thomas, L, Toncic, R J, Tschandl, P, Cabo, H, Hallpern, A, Hofmann‐Wellenhof, R, Malvehy, J, Marghoob, A, Menzies, S, Pellacani, G, Puig, S, et al, University of Zurich, and Errichetti, E

Subjects
2708 Dermatology, 10177 Dermatology Clinic, 610 Medicine & health, Dermatology
Published
2020

23. Clinical and dermatoscopic predictors of squamous cell carcinoma of the lips: a case‐control, multicentric study

Author

Lallas, A., primary, Martínez, G., additional, Arceu, M., additional, Kyrgidis, A., additional, Liopyris, K., additional, Brancaccio, G., additional, Longo, C., additional, Errichetti, E., additional, Sgouros, D., additional, Papageorgiou, C., additional, Fotiadou, C., additional, Siskou, S., additional, Manoli, S.M., additional, Sotiriou, E., additional, Ioannides, D., additional, Katoulis, A., additional, Lazaridou, E., additional, Todorovska, V., additional, Argenziano, G., additional, and Apalla, Z., additional

Published
2021
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26. Cutaneous adverse reactions after m‐RNA COVID‐19 vaccine: early reports from Northeast Italy

Author

Farinazzo, E., primary, Ponis, G., additional, Zelin, E., additional, Errichetti, E., additional, Stinco, G., additional, Pinzani, C., additional, Gambelli, A., additional, De Manzini, N., additional, Toffoli, L., additional, Moret, A., additional, Agozzino, M., additional, Conforti, C., additional, Di Meo, N., additional, Schincariol, P., additional, and Zalaudek, I., additional

Published
2021
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28. The dermatoscopic spectrum of cutaneous lupus erythematosus: A retrospective analysis by clinical subtype with clinicopathological correlation

Author

Apalla, Z. Papadimitriou, I. Iordanidis, D. Errichetti, E. Kyrgidis, A. Rakowska, A. Sotiriou, E. Vakirlis, E. Bakirtzi, A. Liopyris, K. Fotiadou, C. Lazaridou, E. Lallas, A. Ioannidis, D.

Abstract

The skin is the most common organ of involvement during the course of lupus erythematosus (LE). The literature data concerning the dermatoscopic patterns of the different clinical variants of cutaneous LE (CLE), namely chronic (CCLE), subacute (SCLE), and acute (ACLE), are scarce. To determine the dermatoscopic spectrum of CLE and to correlate the dermatoscopic features with the histological findings. This was a retrospective, observational, multicenter, cohort study. We evaluated the dermatoscopic features in a cohort of patients diagnosed with CLE. Furthermore, we investigated their frequency per clinical subtype and correlated them with the anatomic alterations. We included 79 patients. The most prevalent dermatoscopic features of CCLE included follicular plugs (86.4%, P

Published
2020

29. Dermatoscopy of tinea corporis

Author

Lekkas, D., primary, Ioannides, D., additional, Lazaridou, E., additional, Lallas, A., additional, Apalla, Z., additional, Vakirlis, E., additional, Johr, R., additional, Errichetti, E., additional, Kyrgidis, A., additional, and Sotiriou, E., additional

Published
2020
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30. 定义在非癌症皮肤疾病的皮肤镜检查研究中应使用的术语和参数

Author

Errichetti, E., primary, Zalaudek, I., additional, Kittler, H., additional, Apalla, Z., additional, Argenziano, G., additional, Bakos, R., additional, Blum, A., additional, Braun, R., additional, Ioannides, D., additional, Lacarrubba, F., additional, Lazaridou, E., additional, Longo, C., additional, Micali, G., additional, Moscarella, E., additional, Paoli, J., additional, Papageorgiou, C., additional, Russo, T., additional, Scope, A., additional, Stinco, G., additional, Thomas, L., additional, Toncic, R.J., additional, Tschandl, P., additional, Cabo, H., additional, Hallpern, A., additional, Hofmann‐Wellenhof, R., additional, Malvehy, J., additional, Marghoob, A., additional, Menzies, S., additional, Pellacani, G., additional, Puig, S., additional, Rabinovitz, H., additional, Rudnicka, L., additional, Vakirlis, E., additional, Soyer, P., additional, Stolz, W., additional, Tanaka, M., additional, and Lallas, A., additional

Published
2020
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31. Defining the terminology and parameters that should be used in studies into dermoscopy for non‐cancer skin diseases

Author

Errichetti, E., primary, Zalaudek, I., additional, Kittler, H., additional, Apalla, Z., additional, Argenziano, G., additional, Bakos, R., additional, Blum, A., additional, Braun, R., additional, Ioannides, D., additional, Lacarrubba, F., additional, Lazaridou, E., additional, Longo, C., additional, Micali, G., additional, Moscarella, E., additional, Paoli, J., additional, Papageorgiou, C., additional, Russo, T., additional, Scope, A., additional, Stinco, G., additional, Thomas, L., additional, Toncic, R.J., additional, Tschandl, P., additional, Cabo, H., additional, Hallpern, A., additional, Hofmann‐Wellenhof, R., additional, Malvehy, J., additional, Marghoob, A., additional, Menzies, S., additional, Pellacani, G., additional, Puig, S., additional, Rabinovitz, H., additional, Rudnicka, L., additional, Vakirlis, E., additional, Soyer, P., additional, Stolz, W., additional, Tanaka, M., additional, and Lallas, A., additional

Published
2020
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33. Clinical and dermatoscopic predictors of squamous cell carcinoma of the lips: a case‐control, multicentric study.

Author

Lallas, A., Martínez, G., Arceu, M., Kyrgidis, A., Liopyris, K., Brancaccio, G., Longo, C., Errichetti, E., Sgouros, D., Papageorgiou, C., Fotiadou, C., Siskou, S., Manoli, S.M., Sotiriou, E., Ioannides, D., Katoulis, A., Lazaridou, E., Todorovska, V., Argenziano, G., and Apalla, Z.

Subjects
SQUAMOUS cell carcinoma, CHEILITIS, LIPS, LOGISTIC regression analysis
Abstract

Background: Squamous cell carcinoma of the lip accounts for 20% of all oral carcinomas. Its diagnosis may be challenging because it clinically resembles actinic cheilitis and inflammatory lesions of the lips. Objectives: To determine clinical and dermatoscopic predictors of squamous cell carcinoma of the lip vs. other lip lesions. Methods: Multicentre retrospective morphological study, including histologically confirmed cases of squamous cell carcinoma of the lip and controls consisting of actinic cheilitis and inflammatory lesions of the lips. Clinical and dermatoscopic images were evaluated for the presence of predefined criteria. Crude and adjusted odds ratios and corresponding 95% confidence intervals were calculated by univariate and multivariate logistic regression respectively. Results: A total of 177 lip lesions were evaluated, 107 (60.5%) were squamous cell carcinomas and 70 (39.5%) were controls. The most frequent dermatoscopic criteria of lip squamous cell carcinoma were scales (100%), white halos (87.3%) and ulceration (79.4%). The majority of squamous cell carcinomas displayed polymorphic vessels (60.8%), with linear (68.6%) and hairpin (67.6%) being the most frequent types. Multivariate logistic regression analysis showed that clinical predictors of lip squamous cell carcinoma were exophytic appearance and clinical hyperkeratosis, with 43‐fold and 6‐fold higher probability respectively. White clods and ulceration in dermoscopy presented a 6‐fold and 4‐fold increased risk for squamous cell carcinoma respectively. Conclusions: A scaly lesion with exophytic growth, dermatoscopically displaying white clods, ulceration and linear and hairpin vessels is very likely a squamous cell carcinoma of the lip. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Ultrasonographic detection of subclinical enthesitis and synovitis: a possible stratification of psoriatic patients without clinical musculoskeletal involvement

Author

Zuliani, F, Zabotti, A, Errichetti, E, Tinazzi, I, Zanetti, A, Carrara, G, Quartuccio, L, Sacco, S, Giovannini, I, Stinco, G, De Vita, S, Zuliani, F, Zabotti, A, Errichetti, E, Tinazzi, I, Zanetti, A, Carrara, G, Quartuccio, L, Sacco, S, Giovannini, I, Stinco, G, and De Vita, S

Abstract

ObjectiveTo evaluate the prevalence of articular/extra-articular inflammatory lesions and structural damage on ultrasonography in patients suffering from psoriasis as well as to assess possible correlations between ultrasonographic elementary lesions and clinical features.MethodsPsoriatic patients without musculoskeletal symptoms and healthy controls (HCs) were recruited. All patients received a blinded extended ultrasonographic examination of 42 joints, 12 entheses and 32 tendons. Active synovitis was defined by the presence of a grade >= 2 for grey scale (GS) and >= 1 for power Doppler (PD), while active enthesitis corresponded to entheseal hypoecogenicity in GS and entheseal PD signal (<2 mm from bone insertion).ResultsForty psoriatic patients and 20 HCs were included. A total of 2516 joints and 712 entheses were scanned. Active synovitis was found in 11/40 (27.5%) psoriatic patients and 0/20 HCs (p=0.01). Articular synovitis (GS=2) was more frequent in psoriasis than in HCs [ 34/40 (85.0%) and 11/20 (55.0%) respectively; p=0.024). Active enthesitis was found only in psoriatic patients, with a prevalence of 20.0% (8/40) (p=0.04). No significant difference in the prevalence of tenosynovitis or paratenonitis was observed between psoriatic patients and HCs. In psoriasis cohort, age was correlated with the presence of active synovitis (p=0.03), while male sex and a higher PASI score were independently correlated with the presence of active enthesitis (p=0.05 and p=0.034, respectively).ConclusionActive enthesitis and synovitis could be useful to identify subclinical psoriatic arthritis. This might represent a relevant clinical step to better stratify patients with psoriasis.

Published
2019

36. Standardization of dermoscopic terminology and basic dermoscopic parameters to evaluate in general dermatology (non‐neoplastic dermatoses): an expert consensus on behalf of the International Dermoscopy Society

Author

Errichetti, E., primary, Zalaudek, I., additional, Kittler, H., additional, Apalla, Z., additional, Argenziano, G., additional, Bakos, R., additional, Blum, A., additional, Braun, R.P., additional, Ioannides, D., additional, Lacarrubba, F., additional, Lazaridou, E., additional, Longo, C., additional, Micali, G., additional, Moscarella, E., additional, Paoli, J., additional, Papageorgiou, C., additional, Russo, T., additional, Scope, A., additional, Stinco, G., additional, Thomas, L., additional, Toncic, R.J., additional, Tschandl, P., additional, Cabo, H., additional, Hallpern, A., additional, Hofmann‐Wellenhof, R., additional, Malvehy, J., additional, Marghoob, A., additional, Menzies, S., additional, Pellacani, G., additional, Puig, S., additional, Rabinovitz, H., additional, Rudnicka, L., additional, Vakirlis, E., additional, Soyer, P., additional, Stolz, W., additional, Tanaka, M., additional, and Lallas, A., additional

Published
2019
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37. Dermoscopic features of mammary Paget’s disease: a retrospective case‐control study by the International Dermoscopy Society

Author

Apalla, Z., primary, Errichetti, E., additional, Kyrgidis, A., additional, Stolz, W., additional, Puig, S., additional, Malvehy, J., additional, Zalaudek, I., additional, Moscarella, E., additional, Longo, C., additional, Blum, A., additional, Lanssens, S., additional, Savoia, F., additional, Tschandl, P., additional, Kittler, H., additional, Sinz, C., additional, Stinco, G., additional, Argenziano, G., additional, Lazaridou, E., additional, and Lallas, A., additional

Published
2019
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39. Efficacy, tolerability, impact on quality of life and sebostatic activity of three topical preparations for the treatment of mild to moderate facial acne vulgaris

Author

Stinco, G., Piccirillo, F., Francesca Valent, Errichetti, E., Meo, N. D. I., Trevisan, G., Patrone, P., Stinco, G., Piccirillo, F., Valent, F., Errichetti, E., DI MEO, Nicola, Trevisan, Giusto, and Patrone, P.

Subjects
Male, Quality of life, Acne vulgaris, Benzoyl peroxide, Clindamycin phosphate, Sebum, Adolescent, Clindamycin, Administration, Cutaneous, Severity of Illness Index, Drug Combinations, Young Adult, Treatment Outcome, Case-Control Studies, Surveys and Questionnaires, Humans, acne vulgaris, Female, Dermatologic Agents
Abstract

BACKGROUND: Acne is treated according to the clinical observations and pathophysiologically relevant mechanisms, such as hyper--keratinization, seborrhea and bacterial proliferation. In mild and moderate forms of inflammatory acne, topical antimicrobials are recommended as a monotherapy or in combination with topical retinoids. OBJECTIVE: To compare the clinical effectiveness, tolerability, impact on quality of life and effect on sebum excretion of three antimicrobial preparations: clindamycin phosphate, benzoyl peroxide and a combination of clindamycin phosphate plus benzoyl peroxide. METHODS: In total, 240 patients were randomized into treatment groups for an 8--week study. Every two weeks the patients were evaluated using the following methods: photography, the Global Acne Grading System, sebumetric evaluation, and the Acne--Specific Quality of Life questionnaire. In addition, 80 healthy controls were enrolled for the sebumetric evaluation. RESULTS: A significant improvement in acne and the quality of life was observed for all three therapies at the end of the study. The sebum excretion results for the three treatment groups displayed significant and unpredictable variation, whereas the controls groups exhibited no significant variation. The three treatments were well tolerated. CONCLUSIONS: The efficacy of the three antimicrobial preparations likely results from their anti--inflammatory and bacteriostatic activities. In contrast, seborrhoea seems to be minimally impacted.

Published
2016

40. Bullous pemphigoid in a young male after COVID‐19 mRNA vaccine: a report and brief literature review.

Author

Pauluzzi, M., Stinco, G., and Errichetti, E.

Subjects
BULLOUS pemphigoid, COVID-19 vaccines, LITERATURE reviews
Abstract

The patient in this manuscript has given written informed consent to the publication of his case details. Twelve cases developed after Pfizer vaccine and six after Moderna vaccine, with most of them being triggered following the first dose (10 instances compared to eight cases arising after the second dose). Of note, all the cases of COVID-19 vaccine-induced BP has been linked to mRNA vaccines, though it is possible that this finding is the result of the wider use of these types of vaccine worldwide. [Extracted from the article]

Published
2022
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41. Supplementary Material for: Dermoscopy of Granuloma Annulare: A Clinical and Histological Correlation Study

Author

Errichetti, E., Lallas, A., Apalla, Z., Di Stefani, A., and Stinco, G.

Abstract

Background: Dermoscopy of granuloma annulare has been investigated by several studies, but none of them took into account the variability of dermoscopic findings according to clinical characteristics and/or histological subtype. Objective: To describe the dermoscopic features of classic granuloma annulare and seek possible dermoscopic clues related to specific clinical findings/histological subpatterns. Methods: A representative dermoscopic image of a target lesion (the most active lesion underwent histological examination) was retrospectively assessed for the presence of specific morphological findings, correlating them with clinical variables, i.e. disease duration and extension (localized or generalized) and clinical aspect (annular or non-annular) and localization (trunk or extremities) of the biopsied lesion, and with histological subtype. Results: A total of 25 lesions from 25 subjects were analysed; an “interstitial” histological variant was detected in 11 cases, while a “palisading granuloma” histological pattern was found in 14 instances. The most common dermoscopic findings included blurry vessels having variable appearance (dotted, linear-irregular, and branching) over a more or less evident pinkish-reddish background, followed by whitish and/or yellowish-orange areas. Additional findings were rosettes, crystalline structures, and whitish scaling. No difference (p > 0.05) in the frequency of dermoscopic features according to clinical findings was found, while we observed a strict association (p < 0.001) between the presence of yellowish-orange structureless areas on dermoscopy and “palisading granuloma” histology. Conclusion: The dermoscopic aspect of granuloma annulare is independent from clinical features but varies according to histological subtype, with the detection of yellowish-orange colour being indicative of the “palisading granuloma” variant.

Published
2017
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42. Supplementary Material for: Dermoscopy of Morphea and Cutaneous Lichen Sclerosus: Clinicopathological Correlation Study and Comparative Analysis

Author

Errichetti, E., Lallas, A., Apalla, Z., Di Stefani, A., and Stinco, G.

Abstract

Background: Dermoscopy of morphea and cutaneous lichen sclerosus (CLS) has been described by various studies, with none of them considering variability according to clinical phases and investigating dermoscopic-histological correlations. Objective: To evaluate dermoscopic features in general and according to clinical stage, identify possible distinctive dermoscopic clues, and assess dermoscopy accuracy in detecting subclinical alterations in morphea and CLS. Methods: A representative dermoscopic image of target lesions was evaluated for the presence of specific features, correlating them with clinical subtype (inflammatory, inflammatory-sclerotic, sclerotic, or sclerotic-atrophic). In case of clinical-dermoscopic discordance (inflammatory, sclerotic, and atrophic findings in noninflammatory, nonsclerotic, and nonatrophic lesions, respectively), dermoscopic-pathological correspondence was assessed. Results: A total of 86 lesions (51 morphea/35 CLS) were analyzed, with most of them displaying an inflammatory-sclerotic or sclerotic clinical pattern. The most common dermoscopic findings of morphea were “fibrotic beams,” while CLS was mainly characterized by bright white/white-yellowish patches and yellowish-white keratotic follicular plugs; all these structures displayed complete specificity for the correspondent dermatosis. Additionally, pigmentary structures were significantly more frequent in morphea and white scaling and hemorrhagic spots in CLS. Only few dermoscopic features reached a statistical significance for a specific clinical stage. Regarding the clinical-dermoscopic discordance rate, it was significantly more common in morphea than CLS; in all cases there was a correspondence between dermoscopic and pathological findings. Conclusion: Dermoscopy of morphea and CLS reveals distinctive dermoscopic clues which are often unrelated to clinical stage but show a constant histological correspondence, thus emphasizing its usefulness in diagnosis and therapeutic management of these conditions.

Published
2017
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43. Standardization of dermoscopic terminology and basic dermoscopic parameters to evaluate in general dermatology (non‐neoplastic dermatoses): an expert consensus on behalf of the International Dermoscopy Society.

Author

Errichetti, E., Zalaudek, I., Kittler, H., Apalla, Z., Argenziano, G., Bakos, R., Blum, A., Braun, R.P., Ioannides, D., Lacarrubba, F., Lazaridou, E., Longo, C., Micali, G., Moscarella, E., Paoli, J., Papageorgiou, C., Russo, T., Scope, A., Stinco, G., and Thomas, L.

Subjects
*SKIN diseases, *DELPHI method, *DERMATOLOGY, *TERMS & phrases, *PEDIATRIC dermatology
Abstract

Summary: Background: Over the last few years, several articles on dermoscopy of non‐neoplastic dermatoses have been published, yet there is poor consistency in the terminology among different studies. Objectives: We aimed to standardize the dermoscopic terminology and identify basic parameters to evaluate in non‐neoplastic dermatoses through an expert consensus. Methods: The modified Delphi method was followed, with two phases: (i) identification of a list of possible items based on a systematic literature review and (ii) selection of parameters by a panel of experts through a three‐step iterative procedure (blinded e‐mail interaction in rounds 1 and 3 and a face‐to‐face meeting in round 2). Initial panellists were recruited via e‐mail from all over the world based on their expertise on dermoscopy of non‐neoplastic dermatoses. Results: Twenty‐four international experts took part in all rounds of the consensus and 13 further international participants were also involved in round 2. Five standardized basic parameters were identified: (i) vessels (including morphology and distribution); (ii) scales (including colour and distribution); (iii) follicular findings; (iv) 'other structures' (including colour and morphology); and (v) 'specific clues'. For each of them, possible variables were selected, with a total of 31 different subitems reaching agreement at the end of the consensus (all of the 29 proposed initially plus two more added in the course of the consensus procedure). Conclusions: This expert consensus provides a set of standardized basic dermoscopic parameters to follow when evaluating inflammatory, infiltrative and infectious dermatoses. This tool, if adopted by clinicians and researchers in this field, is likely to enhance the reproducibility and comparability of existing and future research findings and uniformly expand the universal knowledge on dermoscopy in general dermatology. What's already known about this topic? Over the last few years, several papers have been published attempting to describe the dermoscopic features of non‐neoplastic dermatoses, yet there is poor consistency in the terminology among different studies. What does this study add? The present expert consensus provides a set of standardized basic dermoscopic parameters to follow when evaluating inflammatory, infiltrative and infectious dermatoses.This consensus should enhance the reproducibility and comparability of existing and future research findings and uniformly expand the universal knowledge on dermoscopy in general dermatology. Linked Editorial: Bahadoran. Br J Dermatol 2020; 182:260–261. Plain language summary available online [ABSTRACT FROM AUTHOR]

Published
2020
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44. SAT0304 Preclinical phases of psoriatic arthritis: a cross-sectional ultrasonographic study on psoriasis and psoriatic arthralgia patients

Author

Zabotti, A., primary, Zuliani, F., additional, Errichetti, E., additional, Tinazzi, I., additional, Sacco, S., additional, Quartuccio, L., additional, Zanetti, A., additional, Batticciotto, A., additional, De Lucia, O., additional, Idolazzi, L., additional, Stinco, G., additional, Iagnocco, A., additional, and De Vita, S., additional

Published
2018
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46. Pruritus in chronic plaque psoriasis: a questionaire based study of 230 patients

Author

Stinco, G, Trevisan, Giusto, Piccirillo, F, Pezzetta, S, Errichetti, E, DI MEO, Nicola, Valent, F, Patrone, P., Stinco, G, Trevisan, Giusto, Piccirillo, F, Pezzetta, S, Errichetti, E, DI MEO, Nicola, Valent, F, and Patrone, P.

Subjects
Psoriasi, Psoriasis, pruritus
Abstract

In the past, several textbooks defined psoriasis as a non-pruritic dermatosis, but the most recent data in the literature emphasizes the high frequency of pruritus in psoriasis and its impact on the quality of life of patients with psoriasis. Aim of this study was to explore the sensory and affective dimensions of pruritus as well as to assess the impact of itch on quality of life and to evaluate the influence of lifestyles, habits, and various anti-pruritic therapies on pruritus in a large group of psoriatic subjects. The structured Yosipovitch itch questionnaire was given to 240 psoriatic patients. 230 patients returned a complete and detailed questionnaire. Pruritus was referred to by 80% of the patients. Psoriasis area and severity index (PASI) was significantly higher in itching-patients (P=0.04). In half of the patients, itching appeared daily, particularly in the evening. Significant aggravating factors of pruritus were stress, skin dryness, hot water, sweating, elevated ambient temperature, exercise, abundant meals, bad moods, lying position, and contact with clothes. Cold water is the only factor that showed to significantly relieve the pruritus. Anti-pruritic therapies had limited effect. Pruritus is a common, bothersome, and poorly responsive symptom in patients with psoriasis.

Published
2014

49. Accuracy of dermoscopy in distinguishing erythroplasia of Queyrat from common forms of chronic balanitis: results from a multicentric observational study.

Author

Errichetti, E., Lallas, A., Di Stefani, A., Apalla, Z., Kyrgidis, A., Lacarrubba, F., Micali, G., Galvan, A., Piaserico, S., and Stinco, G.

Subjects
*PLASMA cells, *SCIENTIFIC observation, *CHI-squared test, *ACCURACY, *DIFFERENTIAL diagnosis
Abstract

Background: Clinical differentiation of erythroplasia of Queyrat (EQ) and chronic forms of balanitis may be challenging, especially in early phases or in overlapping cases. Dermoscopy has been shown to be a useful supportive tool in facilitating the distinction between tumoral and inflammatory skin conditions; yet, data on EQ and balanitis are scarce or sparse. Objectives: To systematically assess the dermoscopic features of both EQ and common forms of chronic balanitis and to investigate the accuracy of dermoscopy in distinguishing these conditions. Methods: Subjects with EQ or chronic balanitis confirmed histologically or microbiologically (for infectious forms) were recruited. A representative dermoscopic image of a target lesion was retrospectively assessed for the presence of specific morphological findings. A correlation matrix was created using Spearman's rho. Proportions of dermoscopic variables scoring among different conditions were compared with the non‐parametric Pearson's chi‐square test. Results: A total of 81 lesions (14 EQ, 23 psoriasis, 31 Zoon plasma cell balanitis and 13 candidal balanitis) from 81 patients were included in the study. Glomerular vessels (both clustered and diffusely distributed) were highly predictive for the diagnosis of EQ, while diffuse dotted vessels were strongly associated with psoriatic balanitis. Finally, Zoon plasma cell balanitis was characterized by orange structureless areas (focal or diffuse) and focused linear curved vessels, whereas cottage cheese‐like structures (sparse white coating corresponding to Candida yeast colonies growth) showed a strong correlation with candidal balanitis. Conclusions: Erythroplasia of Queyrat and balanitis may display different dermoscopic patterns, thereby bearing the usefulness of dermoscopy as a supportive non‐invasive tool for the recognition and differential diagnosis of such conditions. [ABSTRACT FROM AUTHOR]

Published
2019
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