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5 results on '"Ersilia Anghel"'

2. List of contributors

Author

Arad Abadi, Sherwin Abdoli, Benjamin Acton, Alexandra M. Adams, Aderinsola A. Aderonmu, Rakesh Ahuja, Saleh Aiyash, Gabriel Akopian, Benjamin G. Allar, Michael F. Amendola, Taylor Anderson, Athena Andreadis, Darwin N. Ang, Ersilia Anghel, Favour Mfonobong Anthony, Precious Idorenyin Anthony, Jordan C. Apfeld, Youssef Aref, Fernando D. Arias, Margaret Arnold, Abbasali Badami, Jeffrey Alexander Bakal, Varun V. Bansal, J. Barney, Jessica Barson, Lauren L. Beck, Andrew R. Bender, Vivek Bhat, Saptarshi Biswas, David Blitzer, Tayt Boeckholt, John S. Bolton, Sourav K. Bose, Gerald M. Bowers, Mary E. Brindle, Matthew A. Brown, F. Charles Brunicardi, Richard A. Burkhart, Jennifer L. Byk, M. Campbell, Danilea M. Carmona Matos, Kenny J. Castro-Ochoa, Juan Cendan, Shane Charles, Angel D. Chavez-Rivera, Hao Wei Chen, Herbert Chen, Kevin Chen, Wendy Chen, Darren C. Cheng, Nicole B. Cherng, Christina Shree Chopra, G. Travis Clifton, Jason Crowner, Houston Curtis, Temilolaoluwa O. Daramola, Aria Darbandi, Serena Dasani, Kaci DeJarnette, Jeremiah Deneve, Karuna Dewan, Marcus Dial, Jody C. DiGiacomo, Andrew L. DiMatteo, Tsering Y. Dirkhipa, James M. Dittman, Ashley C. Dodd, Israel Dowlat, Hans E. Drawbert, Juan Duchesne, Omar Elfanagely, Yousef Elfanagely, Javed Khader Eliyas, Chukwuma N. Eruchalu, James C. Etheridge, Erfan Faridmoayer, Arjumand Faruqi, Jessica Dominique Feliz, Martin D. Fleming, Laura M. Fluke, Jason M. Flynn, Kathryn L. Fowler, Miguel Garcia, Tushar Garg, Patrick C. Gedeon, Ruby Gilmor, Julie Goldman, Christian Gonzalez, Rachael E. Guenter, Brian C. Gulack, Matthew Handmacher, Ivy N. Haskins, Carl Haupt, Kshipra Hemal, Matthew T. Hey, Perez Holguin, Christopher S. Hollenbeak, Andrew Holmes, Hyo Jung Hong, Nicholas Huerta, Mohamad A. Hussain, Yaritza Inostroza-Nieves, Marc J. Kahn, Sunil S. Karhadkar, Mohammed A. Kashem, Qingwen Kawaji, Syed Faraz Kazim, Kathryn C. Kelley, Monty U. Khajanchi, Shaarif Rauf Khan, Quynh Kieu, Charissa Kim, Roger Klein, Suzanne Kool, Jessica S. Kruger, Afif N. Kulaylat, Audrey S. Kulaylat, Elizabeth Laikhter, Samuel Lance, Megan LeBlanc, David Lee, Frank V. Lefevre, Jacob Levy, Deacon J. Lile, Carol A. Lin, Xinyi Luo, David A. Machado-Aranda, Kashif Majeed, Madhu Mamidala, Nizam Mamode, Abhishek Mane, Samuel M. Manstein, Jenna Maroney, Jessica Maxwell, Patrick M. McCarthy, Philip McCarthy, Hector Mejia, Pallavi Menon, Albert Moeller, Dennis Spalla Morris, Haley Nadone, Anil Nanda, Allison Nauta, Matthew Navarro, Daniel W. Nelson, Daniel C. Neubauer, Kaitlin A. Nguyen, Louis L. Nguyen, Katherine Nielson, Austin O. McCrea, Delia S. Ocaña Narváez, Peter Oro, Gezzer Ortega, Adena J. Osband, Ahmad Ozair, Rohan Palanki, Jaime Pardo Palau, Juliet Panichella, Panini Patankar, Aneri Patel, Nirmit Patel, Gehan A. Pendlebury, Christina Poa-Li, Sangeetha Prabhakaran, Hashir Qamar, Ramesh Raghupathi, Faique Rahman, Mohan Ramalingam, Syed S. Razi, Aminah Abdul Razzack, Abdul Razzaq, Amanda J. Reich, Christopher Reid, Clay Resweber, Mark Riddle, Mehida Rojas-Alexandre, Susan Rowell, Vanessa Roxo, Debosree Roy, Jacqueline L. Russell, Mala Sachdev, Ruben D. Salas-Parra, Ali Salim, John H. Sampson, Andrea Valquiria Sanchez, Tiffany R. Sanchez, Jane R. Schubart, C. Schwartz, Alexander Schwartzman, Erin M. Scott, Ali Seifi, Aditya Sekhani, Chan Shen, Eric Shiah, Jeffrey W. Shupp, Meaghan Sievers, Rachel E. Silver, Kirit Singh, Robert D. Sinyard, Kevin L. Smith, Tandis Soltani, Abhinav Arun Sonkar, Dallas J. Soyland, Mackinzie A. Stanley, David E. Stein, Sean C. Stuart, Linh Tran, Andrew Vierra, Vanessa M. Welten, Kate Whelihan, Brandon M. White, Rebecca L. Williams-Karnesky, Emily E. Witt, Heather X. Rhodes, Seiji Yamaguchi, Ravali Yenduri, Andrew Yiu, Benjamin R. Zambetti, Christa Zino, and Haley A. Zlomke

Published
2023
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4. Clinic-based Debridement of Chronic Ulcers Has Minimal Impact on Bacteria

Author

Paul J, Kim, Christopher E, Attinger, Thomas, Bigham, Robert, Hagerty, Samantha, Platt, Ersilia, Anghel, John S, Steinberg, and Karen K, Evans

Subjects
Adult, Aged, 80 and over, Male, Wound Healing, Treatment Outcome, Debridement, Chronic Disease, Wound Infection, Humans, Female, Middle Aged, Ulcer, Aged
Abstract

Outpatient-based sharp debridement is considered an important element for the care of a chronic ulcer.The aim of this study is to evaluate the change in bacterial amounts with sharp debridement in a clinical setting.Bacterial autofluorescence, quantitative cultures, semiquantitative cultures, and qualitative speciation were performed predebridement and postdebridement during a single clinic visit.Thirty-six wounds were included in the analysis. The mean patient age was 62 years (range, 27-83 years), and there were 13 (36.11%) women and 23 (63.89%) men with an average body mass index of 33.8 kg/m² (range, 16.7-55.9 kg/m²). Of the 36 patients, 24 (66.67%) had type 2 diabetes and 19 (52.78%) had a prior history of lower extremity amputation. Majority of the ulcers were diabetic neuropathic (27, 75%); the most common location was on the plantar aspect of the foot (14, 41.67%) with a mean ulcer duration of 10 months (range, 1-36), mean ulcer area of 6.3 ± 12.8 cm² (range, 0.18-62.06 cm²), and mean volume of 2.2 ± 4.4 cm³ (range, 0.05-9.66 cm³). There was no statistically significant difference in bacterial autofluorescence between the predebridement (4.15 ± 8.82) and the postdebridement (4.65 ± 9.48) images (P = .32). There was a statistically significant difference in quantitative culture results between the predebridement (6.7 x 104 ± 1.4 x 106 CFU/cm²) and the postdebridement (1.7 x 104 ± 3.1 x 106 CFU/cm²) cultures (P = .04), although this is not a log reduction.There is no statistically significant difference between the predebridement versus postdebridement semiquantitative culture results or a detectable pattern of change for the most common bacterial species encountered. These results suggest little impact of clinic-based sharp debridement on bacteria.

Published
2018

5. Aging disrupts cell subpopulation dynamics and diminishes the function of mesenchymal stem cells

Author

Dominik Duscher, Marcelina G. Perez, David Atashroo, Graham G. Walmsley, Ersilia Anghel, Revanth Kosaraju, Sacha M.L. Khong, Robert C. Rennert, Michael S. Hu, Michael Januszyk, Alexander J. Whittam, Zeshaan N. Maan, Atul J. Butte, and Geoffrey C. Gurtner

Subjects
Male, Aging, Population, Cell, Adipose tissue, Biology, Mesenchymal Stem Cell Transplantation, Article, Transcriptome, Neovascularization, Mice, Tubulin, medicine, Human Umbilical Vein Endothelial Cells, Animals, Cluster Analysis, Humans, Gene Regulatory Networks, Progenitor cell, education, Cells, Cultured, education.field_of_study, Wound Healing, Multidisciplinary, Mesenchymal stem cell, Mesenchymal Stem Cells, Coculture Techniques, Mice, Inbred C57BL, medicine.anatomical_structure, Adipose Tissue, Immunology, Cancer research, Cytokines, medicine.symptom, Wound healing, Signal Transduction
Abstract

Advanced age is associated with an increased risk of vascular morbidity, attributable in part to impairments in new blood vessel formation. Mesenchymal stem cells (MSCs) have previously been shown to play an important role in neovascularization and deficiencies in these cells have been described in aged patients. Here we utilize single cell transcriptional analysis to determine the effect of aging on MSC population dynamics. We identify an age-related depletion of a subpopulation of MSCs characterized by a pro-vascular transcriptional profile. Supporting this finding, we demonstrate that aged MSCs are also significantly compromised in their ability to support vascular network formation in vitro and in vivo. Finally, aged MSCs are unable to rescue age-associated impairments in cutaneous wound healing. Taken together, these data suggest that age-related changes in MSC population dynamics result in impaired therapeutic potential of aged progenitor cells. These findings have critical implications for therapeutic cell source decisions (autologous versus allogeneic) and indicate the necessity of strategies to improve functionality of aged MSCs.

Published
2014
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