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7. Measuring the technophobia among middle-aged and older adults in Latvia: A pilot study

Author

Zarina Ilona, Circenis Kristaps, and Erts Renars

Subjects
Social Sciences
Abstract

The increasing need for the development of new solutions for older adults in order to support the independent living at home is perspicuous. The rapid development of information and communication technology will provide capable solutions for maintaining of life quality. Computerized technology is devoted to improving our quality of life. By the way, here is a segment of the population who do not have access to the technology in any way or form because technophobia. The aim of the pilot study was to translate measurement instrument of technophobia “Technophobia test” and collect data needed for analysis and adaptation process. The following research tasks were completed: upon examination of the available literature, the most accepted instruments for measuring technophobia are the Computer Anxiety Rating Scale (Form C), the Computer Thoughts Survey (Form C) and the General Attitudes towards Computers Scale (Form C). In Latvia, up to now such research has not been carried out. Participants (62) were middle-aged and older persons, aged from 45 to 87 years. The descriptive statistic parameters of Technophobia test subscales and the reliability statistical parameter Cronbach's alpha were calculated and average level of technophobia was assessed.

Published
2018
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8. Imaging of laser-excited tissue autofluorescence bleaching rates

Author

Spigulis, Janis, Lihachev, Alexey, and Erts, Renars

Subjects
Imaging systems -- Methods, Tissues -- Properties, Fluorescence -- Research, Lasers -- Usage, Laser, Astronomy, Physics
Abstract

Experimental methodology for imaging of laser-excited tissue autofluorescence bleaching rates has been developed and clinically tested. The fuorescence images were periodically captured from the same tissue area over a certain time, with subsequent detection of the fluorescence intensity decrease rate at each image pixel and further imaging the planar distribution of those values. Spectral features at each image pixel were analyzed with a hyperspectral imaging camera. Details of the equipment and image processing are described as well as some measurement results that confirm the feasibility of the proposed technology. OCIS codes: 170.3880, 170.4580, 170.6935, 170.1870.

Published
2009

9. Simultaneous recording of skin blood pulsations at different vascular depths by multiwavelength photoplethysmography

Author

Spigulis, Janis, Gailite, Lasma, Lihachev, Alexey, and Erts, Renars

Subjects
Plethysmography -- Methods, Blood circulation -- Medical examination, Signal processing -- Methods, Digital signal processor, Astronomy, Physics
Abstract

A new technique for parallel recording of reflection photoplethysmography (PPG) signals in a broad spectral band (violet to near-infrared) has been developed, and its potential for assessment of blood microcirculation at various depths from the skin surface is discussed. PPG signals have been simultaneously detected at cw laser wavelength sets comprising 405, 532, 645, 807, and 1064 nm. Various signal baseline responses to breath holding and different shapes of the PPG pulses originated from the same heartbeat but recorded at different wavelengths have been observed, indicating a depth variety of the skin blood pulsation dynamics. OCIS codes: 170.4580, 170.0170.

Published
2007

16. Naturalistic follow-up study of rehospitalization rates and assigned disability status of patients with first-episode schizophrenia spectrum psychosis in South East Latvia: preliminary results.

Author

Sile, Liene, Bezina, Karina, Kvartalovs, Dmitrijs, Erts, Renars, Kikuste, Sarmite, Sapele, Inna, and Rancans, Elmars

Subjects
PEOPLE with schizophrenia, MENTAL health services, PATIENT readmissions, PSYCHOSES, DRUG prescribing
Abstract

Patients with first-episode schizophrenia spectrum psychosis (FEP) are at risk of not visiting an out-patient psychiatrist and are assigned disability status within a short period after diagnosis. The aim of this study was to conduct a naturalistic follow-up of FEP patients to explore their use of mental healthcare services and the rate of assigned disability status after FEP. This was the first study in Latvia to include all consecutive patients with FEP admitted to the largest regional hospital in South East Latvia, Daugavpils Psychoneurological Hospital (DPNH). Patients received standard treatment in a real-world environment. The mean follow-up time was 33 months (Min = 20 months, Max = 40 months). From the 94 consecutive FEP patients admitted to DPNH (1 January 2016 to 31 December 2017), 68 participated and provided informed consent to be followed up. During the first 12 months after discharge from the acute psychiatric ward, 23% (n = 14) never visited a psychiatrist, and 6.5% (n = 4) had a single visit to get prescription for medication. Furthermore, 36.1% (n = 22) had a rehospitalization during the first 12 months. At the end of follow-up period, 34.4% (n = 21) of patients were assigned disability status within a median time of 8 months (IQR 4.5‒20.0). Approximately, one-third of patients did not continue treatment as out-patients after FEP. One-third of FEP patients were assigned disability status. We suggest that Latvia needs improved treatment options for FEP patients, such as early intervention. [ABSTRACT FROM AUTHOR]

Published
2021
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21. Abstracts from the 5th International Conference for Healthcare and Medical Students (ICHAMS)

Author

Sweeney, Yvonne, primary, O’Neill, Hugh, additional, Duffy, Garry, additional, Creegan, Daniel, additional, Bustos, Viviana, additional, Harvey, Brian J., additional, Dalphy, Alexander, additional, O’Grady, Anthony, additional, Kay, Elaine, additional, Samelska, Katarzyna, additional, Izdebska, Justyna, additional, Kurowska, Anna, additional, Al-Zubaidy, Rena, additional, Mroz, Magdalena, additional, Harvey, Brian, additional, Fagan, Ryan, additional, French, Helen, additional, Cuddy, Vanessa, additional, Ashton, Jennifer, additional, Clarke, Michelle, additional, Sayedalamin, Zaid, additional, Baig, Mukhtiar, additional, Almutairi, Osama, additional, Allam, Hassan, additional, Halawa, Taher F., additional, Atta, Hazem M., additional, Sirone, Linda, additional, Erts, Renars, additional, Pavare, Jana, additional, Richter, Louis, additional, Morris, Joseph, additional, Oglesby, Irene, additional, Dunne, Eimear, additional, Kenny, Dermot, additional, Khayyat, Ibrahim Mohammed Mahdi, additional, Salgado, Viviana Bustos, additional, Tan, Jonavan, additional, Moneley, Daragh, additional, Leahy, Austin, additional, Fitzgerald, Patricia, additional, Fennelly, Evelyn, additional, Harkin, Grace, additional, Lee, John, additional, O’Sullivan, Erica, additional, Kirby, Brian, additional, O’Neill, Sarah, additional, Gonciar, Diana, additional, Mocan, Teodora, additional, Matea, Cristian, additional, Mocan, Lucian, additional, Iancu, Cornel, additional, Doran, Chloe, additional, Hoolahan, Sarah, additional, Engel, Tobias, additional, Alkhattab, Maha, additional, Alekseeva, Tijna, additional, Lackington, William, additional, O’Brien, Fergal, additional, Moollan, Nabeehah, additional, McElvaney, Noel Gerry, additional, Gunaratnam, Cedric, additional, Scanlon, Lorraine, additional, Brady, Noeleen, additional, Timmons, Suzanne, additional, Bresler, Richard, additional, Abreu, Zita, additional, Trohonel, Stefan, additional, Bargman, Joanne, additional, Mirza, Ahmad A., additional, Badrek-Amoudi, Ahmed, additional, Aun, Rakan H., additional, Senan, Hussam A., additional, Mirza, Abdulrahim A., additional, Binsaad, Mohammed S., additional, Farooq, Mian U., additional, Nandi, Saheli, additional, D’Orsi, Beatrice, additional, Prehn, Jochen, additional, Zharova, Mariia, additional, Umrukhin, Pavel, additional, Evans-Uhegbu, Wendy, additional, Doyle, Frank, additional, Kudryashova, Hope, additional, Dorris, Derek, additional, Cummins, Anthony, additional, Doheny-Shanley, Jemma, additional, Woodward, Mark, additional, Hayes, Wesley, additional, Yostos, Marina, additional, Cotter, David, additional, Focking, Melanie, additional, Stancu, Samantha, additional, Iordache, Florin, additional, Popescu, Bogdan A., additional, Akanmu, Muhammad-Mujtaba A., additional, Robert, Alero A., additional, Oridota, Ezekiel O., additional, Alzahrani, Ali K., additional, Alfarhan, Omar, additional, Eldin, Essam Nour, additional, MacManus, Bronagh, additional, Keane, Owen, additional, Hillery, Patrick, additional, Lee, James, additional, O’Reilly, Hugh, additional, Collins, Niamh, additional, Abu saq, Ibrahim, additional, Al Mufarrih, Abdullah, additional, Jaafari, Muath, additional, Al Mahayni, Abdullah, additional, Bawazir, Amen, additional, Alkhateeb, Sultan, additional, Dhannoon, Amenah, additional, Vareslija, Damir, additional, Hill, Arnold, additional, Young, Leonie, additional, Donoghue, Declan, additional, Walsh, Criona, additional, McCabe, Aileen, additional, Pope, John, additional, Pasco, Saturnino, additional, Fallon, Caroline, additional, Solanki, Don, additional, Kiernan, Fiona, additional, Galvin, Sinead, additional, Mucvimicc, Jquan, additional, Mulvihill, Johanna, additional, Elmosry, Soha A., additional, De Souza, Lorenza Andres Ameida, additional, de Oliveira, Yuri, additional, Menezes, Diego, additional, Santos, Alene Vanessa, additional, Asraf, Ahmad Zaki, additional, Stallings, Raymond, additional, Piskareva, Olga, additional, Conlon, Ross, additional, Sweeney-Landers, Siún, additional, Burke, Cathy, additional, Behan, Paraic, additional, Sreenan, Seamus, additional, Organjee, Ahmed, additional, Crosbie-Staunton, Tatsiana, additional, Reeves, Emer, additional, McElvaney, Noel, additional, Mieres, Crystal, additional, Charmsaz, Sara, additional, Al-Jalamdeh, Aya, additional, Corcoran, Mary, additional, McElligott, Martha, additional, Stevens, Niall, additional, Humphreys, Hilary, additional, Barnawi, Rashid, additional, Ghurab, Abdulaziz, additional, Alfaer, Sultan, additional, Balubaid, Hassan, additional, Hanbazazah, Kamal, additional, Bukhari, Mohammed, additional, Alsakkaf, Mohammed, additional, Mirza, Ahmad, additional, Mohammed, Amrallah, additional, Pratanata, Anastasia, additional, Nathania, Maria, additional, Annisa, Tsabita, additional, Dewi, Beti, additional, Lee, Kuok Zhen, additional, Carroll, Tomas P., additional, Fee, Laura, additional, McElvaney, Noel G., additional, White, Rachel C., additional, and Brady, Robert T, additional

Published
2016
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22. Descemet Membrane Endothelial Keratoplasty in Pseudophakic Bullous Keratopathy: Outcomes and Evidence-Based Suggestions.

Author

Borroni, Davide, Ferronato, Melanie, Orube, Ineta, Erts, Renars, Sepetiene, Svetlana, Drucka, Eva, and Krumina, Zita

Subjects
CORNEA surgery, INTRAOCULAR pressure, VISUAL acuity, HEALTH outcome assessment
Abstract

The purpose of the study was to determine clinical outcomes of Descemet Membrane Endothelial Keratoplasty (DMEK) in patients with Pseudophakic Bullous Keratopathy (PBK). The study was conducted at a tertiary referral center. This was a retrospective case series. Pseudophakic eyes having undergone DMEK surgery for Pseudophakic Bullous Keratopathy was considered the object of study. The examination implied the analysis of best corrected visual acuity (BCVA or CDVA), endothelial cell density (ECD), intraocular pressure (IOP), intraoperative and postoperative complications and a follow-up in 1, 3, and 6 months. For the purposes of the study, 25 pseudophakic eyes with PBK were examined. One month after the surgery patients reached a BCVA of 0.49±0.08(M±SD), after 3 months - BCVA of 0.65±0.12(M±SD), and a BCVA of 0.78±0.17 (M±SD) in the last follow-up in 6 months after the surgery (P<0,001). The mean ECD after one month was 1661±133 (M±SD) cells/mm2, after 3 months - 1591±124 (M±SD) cells/mm², and during the last control in 6 months -1579±128 (M±SD) cells/mm². The graft detachment rate was 12% (3 cases). Hypertension was observed in one eye (4%), necessitating partial air elimination through a corneal wound within the first hours after the surgery. DMEK may give excellent visual results in Pseudophakic eyes without increasing the risk of complications when compared to Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) and Penetrating Keratoplasty (PKP). Anatomic repair after DMEK is associated with improved corneal clarity and BCVA. [ABSTRACT FROM AUTHOR]

Published
2018

43. Abstracts from the 5th International Conference for Healthcare and Medical Students (ICHAMS)

Author

Sweeney, Yvonne, O’Neill, Hugh, Duffy, Garry, Creegan, Daniel, Bustos, Viviana, Harvey, Brian J., Dalphy, Alexander, O’Grady, Anthony, Kay, Elaine, Samelska, Katarzyna, Izdebska, Justyna, Kurowska, Anna, Al-Zubaidy, Rena, Mroz, Magdalena, Harvey, Brian, Fagan, Ryan, French, Helen, Cuddy, Vanessa, Ashton, Jennifer, Clarke, Michelle, Sayedalamin, Zaid, Baig, Mukhtiar, Almutairi, Osama, Allam, Hassan, Halawa, Taher F., Atta, Hazem M., Sirone, Linda, Erts, Renars, Pavare, Jana, Richter, Louis, Morris, Joseph, Oglesby, Irene, Dunne, Eimear, Kenny, Dermot, Khayyat, Ibrahim Mohammed Mahdi, Salgado, Viviana Bustos, Tan, Jonavan, Moneley, Daragh, Leahy, Austin, Fitzgerald, Patricia, Fennelly, Evelyn, Harkin, Grace, Lee, John, O’Sullivan, Erica, Kirby, Brian, O’Neill, Sarah, Gonciar, Diana, Mocan, Teodora, Matea, Cristian, Mocan, Lucian, Iancu, Cornel, Doran, Chloe, Hoolahan, Sarah, Engel, Tobias, Alkhattab, Maha, Alekseeva, Tijna, Lackington, William, O’Brien, Fergal, Moollan, Nabeehah, McElvaney, Noel Gerry, Gunaratnam, Cedric, Scanlon, Lorraine, Brady, Noeleen, Timmons, Suzanne, Bresler, Richard, Abreu, Zita, Trohonel, Stefan, Bargman, Joanne, Mirza, Ahmad A., Badrek-Amoudi, Ahmed, Aun, Rakan H., Senan, Hussam A., Mirza, Abdulrahim A., Binsaad, Mohammed S., Farooq, Mian U., Nandi, Saheli, D’Orsi, Beatrice, Prehn, Jochen, Zharova, Mariia, Umrukhin, Pavel, Evans-Uhegbu, Wendy, Doyle, Frank, Kudryashova, Hope, Dorris, Derek, Cummins, Anthony, Doheny-Shanley, Jemma, Woodward, Mark, Hayes, Wesley, Yostos, Marina, Cotter, David, Focking, Melanie, Stancu, Samantha, Iordache, Florin, Popescu, Bogdan A., Akanmu, Muhammad-Mujtaba A., Robert, Alero A., Oridota, Ezekiel O., Alzahrani, Ali K., Alfarhan, Omar, Eldin, Essam Nour, MacManus, Bronagh, Keane, Owen, Hillery, Patrick, Lee, James, O’Reilly, Hugh, Collins, Niamh, Abu saq, Ibrahim, Al Mufarrih, Abdullah, Jaafari, Muath, Al Mahayni, Abdullah, Bawazir, Amen, Alkhateeb, Sultan, Dhannoon, Amenah, Vareslija, Damir, Hill, Arnold, Young, Leonie, Donoghue, Declan, Walsh, Criona, McCabe, Aileen, Pope, John, Pasco, Saturnino, Fallon, Caroline, Solanki, Don, Kiernan, Fiona, Galvin, Sinead, Mucvimicc, Jquan, Mulvihill, Johanna, Elmosry, Soha A., De Souza, Lorenza Andres Ameida, de Oliveira, Yuri, Menezes, Diego, Santos, Alene Vanessa, Asraf, Ahmad Zaki, Stallings, Raymond, Piskareva, Olga, Conlon, Ross, Sweeney-Landers, Siún, Burke, Cathy, Behan, Paraic, Sreenan, Seamus, Organjee, Ahmed, Crosbie-Staunton, Tatsiana, Reeves, Emer, McElvaney, Noel, Mieres, Crystal, Charmsaz, Sara, Al-Jalamdeh, Aya, Corcoran, Mary, McElligott, Martha, Stevens, Niall, Humphreys, Hilary, Barnawi, Rashid, Ghurab, Abdulaziz, Alfaer, Sultan, Balubaid, Hassan, Hanbazazah, Kamal, Bukhari, Mohammed, Alsakkaf, Mohammed, Mirza, Ahmad, Mohammed, Amrallah, Pratanata, Anastasia, Nathania, Maria, Annisa, Tsabita, Dewi, Beti, Lee, Kuok Zhen, Carroll, Tomas P., Fee, Laura, McElvaney, Noel G., White, Rachel C., and Brady, Robert T

Subjects
Meeting Abstracts
Abstract

Table of contents O1: Assessing the protective effect of dexrazoxane against doxorubicin-induced toxicity in HL-1 cardiomyocytes Yvonne Sweeney, Hugh O’Neill, Garry Duffy O2: Role of KCNQ1 in epithelial barrier repair Daniel Creegan, Viviana Bustos, Brian J. Harvey O3: The suitability of non-small cell lung cancer cytology preparations for the analysis of anaplastic lymphoma kinase gene rearrangements Alexander Dalphy, Anthony O’Grady, Elaine Kay O4: Penetrating keratoplasty and descemet’s stripping automated endothelial keratoplasty may lead to deterioration in glaucoma management Katarzyna Samelska, Justyna Izdebska, Anna Kurowska O5: The effect of Resolvin D1 on normal and cystic fibrosis human bronchial epithelium Rena Al-Zubaidy, Magdalena Mroz, Brian Harvey O6: Validity of clinical assessment compared with plantar fascia thickness on ultrasound for plantar fasciitis: a cross-sectional study Ryan Fagan, Helen French, Vanessa Cuddy, Jennifer Ashton, Michelle Clarke P1: Undergraduate medical research in Gulf Cooperation Council (GCC) countries: A descriptive study of students’ views Zaid Sayedalamin, Mukhtiar Baig, Osama Almutairi, Hassan Allam, Taher F. Halawa, Hazem M. Atta P2: Positive fluid balance as a prognostic factor in children with sepsis during first 3 hours of resuscitation in intensive care unit Linda Sirone, Renars Erts, Jana Pavare P3: Patients on aspirin: Too little or too much? Louis Richter, Joseph Morris, Irene Oglesby, Eimear Dunne, Dermot Kenny P4: Beta catenin/TCF4 activation reduces KCNQ1 current in colonic monolayers Ibrahim Mohammed Mahdi Khayyat, Viviana Bustos Salgado, Brian J. Harvey P5: Size Matters. Abdominal aortic aneurysm: adherence to surveillance imaging guidelines Jonavan Tan, Daragh Moneley, Austin Leahy, Patricia Fitzgerald P6: Endoscopic retrograde cholangiopancreatography in the west of Ireland: Procedural outcomes and peri-procedural complications Evelyn Fennelly, Grace Harkin, John Lee P7: The effect of the extracellular redox environment on polyamine-platelet interactions Erica O’Sullivan, Brian Kirby, Sarah O’Neill P8: Functionalized gold nanoparticles: preliminary data on in vitro toxicity and comparative photothermal effect Diana Gonciar, Teodora Mocan, Cristian Matea, Lucian Mocan, Cornel Iancu P9: Imaging proteasomal inhibition after seizures in the brain: A study into cellular activity in the hippocampus of epileptic transgenic mice Chloe Doran, Sarah Hoolahan, Tobias Engel P10: Investigating the ability of the Olfactory epithelial stem cells to differentiate into glial cells by assessing cell morphology and marker expression Maha Alkhattab, Tijna Alekseeva, William Lackington, Fergal O’Brien P11: Beaumont Hospital cystic fibrosis service audit and annual report Nabeehah Moollan, Chloe Doran, Noel Gerry McElvaney, Cedric Gunaratnam P12: Quick cognitive screening: the 6-item cognitive impairment test and the temporal orientation score Lorraine Scanlon, Noeleen Brady, Suzanne Timmons P13: Granular analysis of causes of peritoneal dialysis technique failure in the first six months of therapy Richard Bresler, Zita Abreu, Stefan Trohonel, Joanne Bargman P14: Job satisfaction of surgeons working in hajj pilgrimage: a multicenter study Ahmad A. Mirza, Ahmed Badrek-Amoudi, Rakan H. Aun, Hussam A. Senan, Abdulrahim A. Mirza, Mohammed S. Binsaad, Mian U. Farooq P15: Investigation of the role of Bok using wild-type, bax-, bok-, and bax/bok-double-deficient mice Saheli Nandi, Beatrice D’Orsi, Jochen Prehn P16: Is it possible to predict resistance of an organism to stress based on the level of corticosterone? Mariia Zharova, Pavel Umrukhin P17: Investigating the strength model of self-regulation (ego depletion) and medical decision making and error in medical students Wendy Evans-Uhegbu, Frank Doyle, Hope Kudryashova, Derek Dorris, Anthony Cummins P18: Does bladder drainage with intermittent catheterisation preserve kidney function in boys with posterior urethral valves? Jemma Doheny-Shanley, Mark Woodward, Wesley Hayes P19: Investigating the role of Stonin 2, a Clathrin Mediated Endocytosis adaptor protein, in altered hippocampal synaptic transmission characterized in schizophrenia Marina Yostos, David Cotter, Melanie Focking P20: Predicting complications after colon resection Samantha Stancu, Florin Iordache, Bogdan A. Popescu P21: Knowledge, attitude and practice of the methods of primary and secondary prevention of cervical cancer among NYSC members in Lagos state, Nigeria Muhammad-Mujtaba A. Akanmu, Alero A. Robert, Ezekiel O. Oridota P22: Incidental glucose and lipid metabolisms disorders among office workers: a cross sectional study Ahmad A. Mirza, Ali K. Alzahrani, Omar Alfarhan, Essam Nour Eldin P23: Differentiating clinically significant spinal injuries; a review of emergency department presentations Bronagh MacManus, Owen Keane, Patrick Hillery, James Lee, Hugh O’Reilly, Niamh Collins P24: Pattern of renal colic occurrence due to urinary stones during Ramadan and other months of the year at King Abdulaziz Medical City, Riyadh, KSA Ibrahim Abu saq, Abdullah Al Mufarrih, Muath Jaafari, Abdullah Al Mahayni, Amen Bawazir, Sultan Alkhateeb P25: Proteomic analysis reveals novel AIB1 co-factors that may contribute to acquired endocrine resistance in breast cancer Amenah Dhannoon, Damir Vareslija, Arnold Hill, Leonie Young P26: Improving sedation practice in general ICU in Beaumont Hospital Declan Donoghue, Criona Walsh, Aileen McCabe, John Pope, Saturnino Pasco, Caroline Fallon, Don Solanki, Fiona Kiernan, Sinead Galvin, Jquan Mucvimicc, Johanna Mulvihill P27: Diagnosis and control of hypertension as indicators of the level of awareness among relatives of medical students Ahmad A. Mirza, Soha A. Elmosry P28: Evaluation of the antitumor potential from extracts of endemic plants of Brazilian caatinga against melanoma and hepatocarcinoma Lorenza Andres Ameida De Souza, Yuri de Oliveira, Diego Menezes, Alene Vanessa Santos P29: The role of Chromogranin A as a biomarker in drug resistant neuroblastoma Ahmad Zaki Asraf, Raymond Stallings, Olga Piskareva, Ross Conlon P30: Membrane sweep at term gestation in CUMH; a case-control study Siún Sweeney-Landers, Cathy Burke P31: Study of the variability of glucose levels in patients with diabetes undergoing continuous glucose monitoring Paraic Behan, Seamus Sreenan P32: Inflammatory cytokine response to decreased plasma alpha-1 antitrypsin levels in individuals with the MZ genotype Ahmed Organjee, Tatsiana Crosbie-Staunton, Emer Reeves, Noel McElvaney P33: Analysing the role of SRC-1 in breast cancer stem cell formation and activity Crystal Mieres, Leonie Young, Sara Charmsaz P34: Screening Streptococcus pneumoniae isolates for virulence genes Aya Al-Jalamdeh, Mary Corcoran, Martha McElligott, Niall Stevens, Hilary Humphreys P35: Assessment of the relevance of admission clerking criteria taught to medical students at King Abdulaziz University to real hospital practice Rashid Barnawi, Abdulaziz Ghurab, Sultan Alfaer, Hassan Balubaid, Kamal Hanbazazah, Mohammed Bukhari P36: Pattern of emergency department visits during Hajj period Mohammed Alsakkaf, Ahmad Mirza, Amrallah Mohammed P37: Anti-Dengue activity of Aspergillus terreus (sulochrin); An in vitro study Anastasia Pratanata, Maria Nathania, Tsabita Annisa, Beti Dewi P38: The comorbidome in alpha-1 antitrypsin deficiency Kuok Zhen Lee, Tomas P. Carroll, Laura Fee, Noel G. McElvaney P39: MLO-Y4 cells behave more like osteocytes in response to mechanical stimulation when cultured in 3D Rachel C. White, Robert T Brady, Fergal O’Brien

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44. A population based study of multiple myeloma patients with medication-related osteonecrosis of the jaw.

Author

Auzina D, Slaidina A, Sevastjanova M, Erts R, Lejnieks A, and Lejniece S

Subjects
Humans, Latvia, Retrospective Studies, Bisphosphonate-Associated Osteonecrosis of the Jaw, Bone Density Conservation Agents, Multiple Myeloma
Abstract

Objective: Medication-related osteonecrosis of the jaw (MRONJ) is a rare complication of antiresorptive or antiangiogenetic therapy that manifests as an exposed bone with clinical signs of infection, persisting for more than 8 weeks, without history of radiation therapy or metastases to the jaws. The aim of the study was to describe the incidence, risk factors, staging process and clinical course of MRONJ in patients with multiple myeloma (MM)., Materials and Methods: We retrospectively analyzed all (126) newly diagnosed MM patients at Riga East Clinical University Hospital (Riga. Latvia) from June 2014 to June 2017., Results: Among 88 MM patients treated with bisphosphonates (BP), 6 (6.8%) patients developed MRONJ. All six patients received intravenous nitrogen-containing BPs. The average time until MRONJ manifestation was under two years. For our patients the severity of MRONJ was stage I in two, stage II in three, and stage III in one patient. Five patients had MRONJ of mandibula and one of maxilla. All patients with MRONJ had undergone a dental extraction or a trauma before the development of MRONJ., Conclusion: We found that MRONJ correlated with the patient's age. The average time until MRONJ manifestation in reserach group is 2 years. One of triggerring MRONJ factors are tooth extraction or trauma.

Published
2019

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