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14. A longitudinal communication approach in advanced lung cancer: A qualitative study of patients', relatives' and staff's perspectives

Author

Villalobos, M., Coulibaly, K., Krug, K., Kamradt, M., Wensing, M., Siegle, A., Kuon, J., Eschbach, C., Tessmer, G., Winkler, E., Szecsenyi, J., Ose, D., Thomas, M., Villalobos, M., Coulibaly, K., Krug, K., Kamradt, M., Wensing, M., Siegle, A., Kuon, J., Eschbach, C., Tessmer, G., Winkler, E., Szecsenyi, J., Ose, D., and Thomas, M.

Abstract

Item does not contain fulltext, Communication and the care of patients with advanced cancer are a dynamic, interactive and challenging process, often characterised in every day practice by discontinuity and lack of coordination. The objective of this study was to explore the patients' and family-caregivers' needs and preferences regarding communication, quality of life and care over the trajectory of disease. The second aim was to assess health professionals' views on a longitudinally structured, forward-thinking communication approach based on defined milestones. A qualitative approach was chosen incorporating semi-structured interviews with nine patients with metastatic lung cancer and nine relatives, and focus groups with 15 healthcare providers from different professions involved in the care of these patients. Patients and relatives described a situation of shock and coping deficits with moments of insufficient communication and lack of continuity in care. Healthcare providers reported the strong need for improvement in communication within the team and between patients and professionals and welcomed the implementation of a longitudinal communication approach. Requirements for the implementation of a longitudinal communication approach include specific communication training with focus on the process that patients and relatives are involved in. Team-building measures and the necessary flexibility to respect individuality in life should be incorporated.

Published
2018

15. A longitudinal communication approach in advanced lung cancer: A qualitative study of patients’, relatives’ and staff's perspectives

Author

Villalobos, M., primary, Coulibaly, K., additional, Krug, K., additional, Kamradt, M., additional, Wensing, M., additional, Siegle, A., additional, Kuon, J., additional, Eschbach, C., additional, Tessmer, G., additional, Winkler, E., additional, Szecsenyi, J., additional, Ose, D., additional, and Thomas, M., additional

Published
2017
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16. spiel ohne grenzen/pou2 Is Required for Early Steps in the Establishment of the Zebrafish Mid-/Hindbrain Boundary

Author

Belting, H.-G., Hauptmann, G., Meyer, D., Abdelilah-Seyfried, S., Chitnis, A. J., Eschbach, C., Thisse, C., Thisse, B., Soll, I., Artinger, K. B., and Driever, W.

Subjects
Zebra fish -- Genetic aspects, Developmental genetics -- Research, Developmental neurology -- Research, Biological sciences
Abstract

The vertebrate midbrain-hindbrain boundary (MHB) organizes patterning and neuronal differentiation in the midbrain and anterior hindbrain. Formation of this organizing center involves distinct steps, including (i) positioning of the MHB in the neural plate, (ii) establishment, and (iii) maintenance of its regional identity and signaling activity. How MHB-specific gene expression is achieved is not yet understood. We are studying the role of the spiel-ohne-grenzen (spg) gene in MHB formation. We have identified pou2, a member of the POU family of transcription factors, as the gene affected in the spg mutation, pou2 is transiently expressed during late gastrulation and early somitogenesis in the mid- and anterior hindbrain. Expression of otx2 and gbx2 initiates accurately, indicating that positioning of the MHB is normal in spg mutants. In contrast, early MHB markers such as wntl, pax2.1, and eng2 require spg/pou2 for proper initiation of their MHB expression domains during late gastrulation. Our data show that spg/pou2 is required for the establishment of the MHB and that it plays a critical role in the regulation of MHB-specific genes.

Published
2001

18. Differential conditioning and long-term olfactory memory in individual Camponotus fellah ants

Author

Josens, R., Eschbach, C., and Giurfa, M.

Subjects
Camponotus fellah, conditioned reflex, odor, Ants, Conditioning, Classical, article, association, Olfaction, Long-term memory, memory, Smell, physiology, Learning, Animals, animal, Ant, Cues, Formicidae, Conditioning
Abstract

Individual Camponotus fellah ants perceive and learn odours in a Y-maze in which one odour is paired with sugar (CS+) while a different odour (CS-) is paired with quinine (differential conditioning). We studied olfactory retention in C. fellah to determine whether olfactory learning leads to long-term memory retrievable 24h and 72 h after training. One and 3days after training, ants exhibited robust olfactory memory through a series of five successive retention tests in which they preferred the CS+ and stayed longer in the arm presenting it. In order to determine the nature of the associations memorized, we asked whether choices within the Y-maze were driven by excitatory memory based on choosing the CS+ and/or inhibitory memory based on avoiding the CS-. By confronting ants with a novel odour vs either the CS+ or the CS- we found that learning led to the formation of excitatory memory driving the choice of the CS+ but no inhibitory memory based on the CS- was apparent. Ants even preferred the CS- to the novel odour, thus suggesting that they used the CS- as a contextual cue in which the CS+ was embedded, or as a second-order cue predicting the CS+ and thus the sugar reward. Our results constitute the first controlled account of olfactory long-term memory in individual ants for which the nature of associations could be precisely characterized. Fil:Josens, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Giurfa, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.

Published
2009

21. 9096 POSTER EGFR-targeting Chimeric Monoclonal lgG-1 Antibody Cetuximab in a Phase ll/lll Study Added Either to Gemcitabine Followed by Docetaxel or Carboplatin Plus Gemcitabine for Chemonaive Patients With Advanced Non-small Cell Lung Cancer (NSCLC) – Results of the Phase II Study Part

Author

Kortsik, C., primary, Schmid-Bindert, G., additional, Pilz, L.R., additional, Cicenas, S., additional, Eschbach, C., additional, Kollmeier, J., additional, Schumann, C., additional, Serke, M., additional, Steins, M., additional, and Manegold, C., additional

Published
2011
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23. Klinisches Management von Patienten mit nicht-kleinzelligem Lungenkrebs (NSCLC) im Therapiealltag in Deutschland: Daten der europäischen EPICLIN-Lung Studie

Author

Serke, M, primary, Reck, M, additional, Eberhardt, W, additional, Schütte, W, additional, Fischer, J, additional, Pawel, J von, additional, Eschbach, C, additional, Gütz, S, additional, Shumann, C, additional, Bischoff, HG, additional, Moldenhauer, I, additional, and Thomas, M, additional

Published
2011
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28. Cetuximab combined with either gemcitabine (G) followed by docetaxel (D) or carboplatin/gemcitabine (CP/G) in chemotherapy-naive patients (pts) with advanced non-small cell lung cancer (NSCLC): Safety profile from the ongoing phase II/III GemTax IV trial

Author

Serke, M., primary, Pilz, L. R., additional, Cicenas, S., additional, Eschbach, C., additional, Fischer, J., additional, Kortsik, C., additional, Schumann, C., additional, Steins, M., additional, and Manegold, C., additional

Published
2009
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32. Palliativmedizin in der Pneumologie

Author

Magnussen, H., primary, Heigener, D., additional, Bausewein, C., additional, Thomas, M., additional, Eschbach, C., additional, Schütte, W., additional, Blankenburg, T., additional, Steins, M., additional, Bischoff, H., additional, Schucher, B., additional, Rosseau, S., additional, Schütz, A., additional, Geiseler, J., additional, Kampf, S., additional, and Karg, O., additional

Published
2009
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35. FLEX: Cetuximab in Kombination mit Platin-basierter Chemotherapie (CT) verlängert das Überleben in der Erstlinientherapie von Patienten mit fortgeschrittenem nicht-kleinzelligen Bronchialkarzinom (non-small cell lung cancer, NSCLC) im Vergleich zur alleinigen CT

Author

Heigener, D, primary, Pawel, J von, additional, Kortsik, C, additional, Fischer, JR, additional, Bischoff, HG, additional, Pirker, R, additional, Gatzemeier, U, additional, Eschbach, C, additional, and Schütte, W, additional

Published
2009
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38. Feasibility of cetuximab in combination with gemcitabine or docetaxel or carboplatin/gemcitabine for chemonaïve patients with advanced non-small cell lung cancer (NSCLC): Observations from an ongoing randomized phase II/III trial (GemTax IV)

Author

Pilz, L. R., primary, Cicenas, S., additional, Eschbach, C., additional, Fischer, J. R., additional, Kortsik, C., additional, Schumann, C., additional, Serke, M., additional, Steins, M., additional, and Manegold, C., additional

Published
2008
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48. spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer.

Author

Belting, H G, Hauptmann, G, Meyer, D, Abdelilah-Seyfried, S, Chitnis, A, Eschbach, C, Söll, I, Thisse, C, Thisse, B, Artinger, K B, Lunde, K, and Driever, W

Abstract

The vertebrate midbrain-hindbrain boundary (MHB) organizes patterning and neuronal differentiation in the midbrain and anterior hindbrain. Formation of this organizing center involves multiple steps, including positioning of the MHB within the neural plate, establishment of the organizer and maintenance of its regional identity and signaling activities. Juxtaposition of the Otx2 and Gbx2 expression domains positions the MHB. How the positional information is translated into activation of Pax2, Wnt1 and Fgf8 expression during MHB establishment remains unclear. In zebrafish spiel ohne grenzen (spg) mutants, the MHB is not established, neither isthmus nor cerebellum form, the midbrain is reduced in size and patterning abnormalities develop within the hindbrain. In spg mutants, despite apparently normal expression of otx2, gbx1 and fgf8 during late gastrula stages, the initial expression of pax2.1, wnt1 and eng2, as well as later expression of fgf8 in the MHB primordium are reduced. We show that spg mutants have lesions in pou2, which encodes a POU-domain transcription factor. Maternal pou2 transcripts are distributed evenly in the blastula, and zygotic expression domains include the midbrain and hindbrain primordia during late gastrulation. Microinjection of pou2 mRNA can rescue pax2.1 and wnt1 expression in the MHB of spg/pou2 mutants without inducing ectopic expression. This indicates an essential but permissive role for pou2 during MHB establishment. pou2 is expressed normally in noi/pax2.1 and ace/fgf8 zebrafish mutants, which also form no MHB. Thus, expression of pou2 does not depend on fgf8 and pax2.1. Our data suggest that pou2 is required for the establishment of the normal expression domains of wnt1 and pax2.1 in the MHB primordium.

Published
2001

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