1. Course of life into adulthood of patients with biliary atresia: the achievement of developmental milestones in a nationwide cohort.
- Author
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Potgieser AR, de Vries W, Sze YK, Sieders E, Verkade HJ, Porte RJ, Hoekstra-Weebers JE, Hulscher JB, Aronson DC, Damen G, Escher JH, van Heurn LW, Houwen RH, Heij HA, Hulscher JB, Kneepkens CM, Koot BG, de Langen ZJ, Madern G, van den Neucker AM, Peeters PM, Verkade HJ, de Vries W, and van der Zee DC
- Subjects
- Adult, Antisocial Personality Disorder epidemiology, Antisocial Personality Disorder psychology, Biliary Atresia surgery, Cohort Studies, Cross-Sectional Studies, Female, Gambling epidemiology, Gambling psychology, Humans, Independent Living psychology, Liver Transplantation, Male, Netherlands, Portoenterostomy, Hepatic, Sexual Dysfunctions, Psychological epidemiology, Sexual Dysfunctions, Psychological psychology, Social Adjustment, Substance-Related Disorders epidemiology, Substance-Related Disorders psychology, Surveys and Questionnaires, Young Adult, Biliary Atresia epidemiology, Biliary Atresia psychology, Developmental Disabilities epidemiology, Developmental Disabilities psychology
- Abstract
Purpose: To investigate the course of life of young adults diagnosed with biliary atresia (BA) in infancy by comparing patients who did and did not underwent transplantation with an age-matched Dutch reference group., Methods: All patients from the Dutch BA registry, aged >18 years, were invited to complete the course of life questionnaire., Results: Forty patients participated (response = 74%). Twenty-five had not undergone transplantation; 15 had undergone orthotopic liver transplantation. One significant between-group difference was found, namely in substance use and gambling. BA patients who underwent transplantation reported less use than the reference group (p = .01, moderate effect size). Additional moderate effect sizes were found for differences in psychosexual and social development and antisocial behavior. Patients who underwent transplantation had lower scores than one or both other groups., Conclusions: Development of BA survivors who did not undergo transplantation seems not delayed, whereas that of transplanted patients does seem somewhat delayed. However, patients who underwent transplantation display less risk behavior. Larger samples are necessary to confirm these findings., (Copyright © 2012 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.)
- Published
- 2012
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