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International audience; The progress of science and technology has considerably increased the quality of life - especially the material standard of living - (e.g. disappearance of famines, increase in life expectancy) On the other hand, climate change, reduction of biodiversity, decrease of natural resources, and increase of environmental risks are some of the consequences of this human activities. Addressing these new challenges will require holistic comprehension and actionable approaches. The mitigation of these consequences requires effective responses in terms of transition. In this context, engineering and design students need time but also adapted curricula focused on sustainability and eco design concepts to support evolution of their skills, their knowledge and their culture. This article discusses the integration of a strong sustainability knowledge within the ideation process through a pedagogical experience, in order to develop new knowledge-based approaches, methodologies and tools

National audience

National audience; Jusqu'à présent, la recherche sur la soutenabilité s’est centrée principalement au niveau macro sur les acteurs institutionnels et les efforts de changement systémique. Au niveau micro, les chercheurs ont étudié le choix des produits par les consommateurs et leur élimination après usage [1].Le projet D-TechnoSS, financé par l'Agence nationale de la recherche (ANR) (ANR-20-CE10-0006), vise à développer une meilleure compréhension des mécanismes de prise de conscience et de changements des comportements associés à l’adoption de démarches de conception participatives dans une posture de soutenabilité forte.Le projet D-TechnoSS vise à explorer la proposition d’une intégration forte entre société et système de production. Dans le cadre du projet, il sera question de favoriser la prise de conscience des défis sociétaux, de faciliter le changement de comportements peu soutenables et d’accompagner le système productif dans on retour au seuil des limites planétaires. La méthode de recherche est basée sur une approche expérimentale, pour proposer un modèle d’évaluation de la soutenabilité dans une posture de soutenabilité forte.Le projet D-TechnoSS a donc pour ambition de mieux comprendre et accompagner les transitions sociales ainsi que l’adaptation nécessaire du système de production et des méthodes de conception.

Cette recherche est financée par l’Agence nationale de la recherche dans le cadre du projet D-TechnoSS ANR-20-CE10-0006; National audience

Orientadores: Sandra Martha Gomes Dias, Ana Carolina de Mattos Zeri Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia Resumo: Grandes avanços foram feitos ao longo dos anos em nossa compreensão sobre o câncer, mas muitos detalhes relativos aos mecanismos responsáveis pelo desenvolvimento tumoral ainda não são completamente entendidos. Recentemente, a capacidade de reprogramar o metabolismo energético foi reconhecida como um dos hallmarks da transformaçao tumoral. Seu estudo e compreensão tem aberto novas e promissoras portas para a busca de alvos terapêuticos. Cerca de 10-20% dos casos de câncer de mama diagnosticados correspondem ao subtipo triplo-negativo (TN), o qual não expressa os receptores dos hormônios estrogênio e progesterona e não apresenta amplificação de HER2. Os tumores TN apresentam um perfil molecular único, comportamento agressivo e pior prognóstico em relação a outros subtipos de câncer de mama. Além, os tumores TN não respondem aos tratamentos convencionais desenvolvidos para a doença, o que ressalta a necessidade de se procurar novas estratégias terapêuticas. Tumores TN tem captação aumentada de 2-deoxi-2- (18F) fluoro-D-glicose (FDG) e dependência de glutamina, o que se correlaciona com seu alto índice proliferativo e evidencia a intensificação da glicólise aeróbica ou efeito Warburg. Neste trabalho, objetivamos analisar a expressão gênica diferencial e de metabólitos de linhagens celulares e tecidos tumorais de mama TN e não-TN de maneira a se caracterizar a assinatura metabólica do subtipo TN. Por fim, objetivamos identificar potenciais novo alvos terapêuticos para o tratamento deste subtipo tumoral. Como resultados, verificamos que tumores TN apresentam características que potencialmente lhes garantem uma alta eficiência no uso de nutrientes, com alta captação e processamento de glicose, alto processamento de glutamina, re-aproveitamento de lactato e utilização de acetaldeídos como fonte energética e biossintética. No último caso, lhe grantindo, uma potencial via de quimioresistência. Há ainda a indicação de ativação de vias de síntese/modificação de lipídeos que podem ter uma função sinalizadora nas células. Por fim, foi gerada uma lista de 73 genes com expressão aumentada em tumores de mama TN (em relação a não-TN). Desta lista, GBP1, uma guanylate-binding protein, mostrou diminuir seletivamente a proliferação celular de linhagens TN quando silenciado. Sua função para o estabelecimento/progressão/sobrevivência do subtipo TN precisa ser avaliada de maneira a confirmá-la como alvo para o tratamento desta doença Abstract: Great advances have been made over the years in our understanding of cancer, but many details of the mechanisms involved for tumor development are not yet fully understood. Recently, the ability to reprogram the energy metabolism was recognized as one of the hallmarks of tumoral transformation. His study and understanding has opened promising new doors in the search for therapeutic targets. About 10-20% of cases of breast cancer diagnosed corresponds to triple negative (TN) subtype, which does not express the hormones receptors of estrogen and progesterone and does not have HER2 amplification. TN tumors have a unique molecular profile, an aggressive behavior and a poor prognosis compared to others breast cancer subtypes. In addition, TN tumors do not respond to conventional treatments developed for the disease, which highlights the need to look for new therapeutic strategies. TN tumors increase the uptake of 2-deoxy-2- (18F) fluoro-D-glucose (FDG) and has a glutamine dependence, which correlates with their high proliferative index and demonstrates the enhancement of aerobic glycolysis or Warburg effect. In this study, we aimed to analyze differential gene expression and metabolomics from cell lines and tumor breast tissues TN and not TN (N-TN) subtypes in order to characterize the metabolic signature. Finally, we aimed to identify potential therapeutic targets for treatment of this tumor subtype (TN). As a result, we found that TN tumors potentially have characteristics that guarantee them a high efficiency in the use of nutrients, with high uptake and processing of glucose, high glutamine processing, re-use lactate and use of acetaldehyde as energy and biosynthetic source. This last resource could be an important way of chemoresistance. There is also activation of synthesis and modification pathways of lipids that can have important signaling function in cells. Finally, we generated a list of 73 genes with increased expression in TN breast tumors (relative to non-TN) and from this list, GBP1 a guanylate-binding protein, shown to reduce selectively the cell proliferation in TN cell lines when muted. Its function for the establishment / progression / survival TN subtype must be evaluated to confirm it or not as a potential target to treat this disease Doutorado Fármacos, Medicamentos e Insumos para Saúde Doutora em Ciências FAPESP 2012/09452-9

Supplemental material, sj-pdf-3-tub-10.1177_1010428320977124 for Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation by Maria Prates Rivas, Talita Ferreira Marques Aguiar, Mariana Maschietto, Renan B Lemes, Luiz Carlos Caires-Júnior, Ernesto Goulart, Kayque Alves Telles-Silva, Estela Novak, Lilian Maria Cristofani, Vicente Odone, Monica Cypriano, Silvia Regina Caminada de Toledo, Dirce Maria Carraro, Melissa Quintero Escobar, Hana Lee, Michael Johnston, Cecilia Maria Lima da Costa, Isabela Werneck da Cunha, Ljubica Tasic, Peter L Pearson, Carla Rosenberg, Nikolai Timchenko and Ana Cristina Victorino Krepischi in Tumor Biology

El presente trabajo tiene como finalidad la elaboración de una campaña de comunicación integral para la Asociación Peruana de Viajes y Turismo (APAVIT) en un contexto de crisis causado por la pandemia mundial del COVID-19. A través de esta campaña, se buscará captar a un público objetivo Millennial con el objetivo de dar a conocer a la asociación y motivarlos a viajar por el Perú a través de agencias de viaje cuando se reinicien las actividades en el sector turismo. The purpose of this work is to develop a comprehensive communication campaign for the Peruvian Association of Travel and Tourism Agencies (APAVIT) in a context of crisis caused by the global pandemic of COVID-19. This campaign will seek to attract a Millennial target audience with the aim of advertising the association and motivate them to travel through Peru using travel agencies when activities in the tourism sector resume. The purpose of this work is to develop a comprehensive communication campaign for the Peruvian Association of Travel and Tourism Agencies (APAVIT) in a context of crisis caused by the global pandemic of COVID-19. This campaign will seek to attract a Millennial target audience with the aim of advertising the association and motivate them to travel through Peru using travel agencies when activities in the tourism sector resume.

Psychiatric disorders are some of the most impairing human diseases. Among them, bipolar disorder and schizophrenia are the most common. Both have complicated diagnostics due to their phenotypic, biological, and genetic heterogeneity, unknown etiology, and the underlying biological pathways, and molecular mechanisms are still not completely understood. Given the multifactorial complexity of these disorders, identification and implementation of metabolic biomarkers would assist in their early detection and diagnosis and facilitate disease monitoring and treatment responses. To date, numerous studies have utilized metabolomics to better understand psychiatric disorders, and findings from these studies have begun to converge. In this chapter, we briefly describe some of the metabolomic biomarkers found in these two disorders Fechado

El respeto por la dignidad humana y la igualdad real y efectiva, constituyen una condición, sin la cual es imposible lograr un desarrollo social que de cumplimiento a los fines del Estado, es por esto que a este le corresponde promover condiciones para garantizar esta igualdad y adoptar medidas a favor de grupos discriminados o marginados. La Constitución Política de 1991 dio la posibilidad de dar un gran salto social creando un marco normativo garantista, que permite la inclusión efectiva en la sociedad de las personas con discapacidad.