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13. Cancer patients treated with intravenous chemotherapy for the first time. What are their needs? What do they lack? A qualitative–quantitative mixed approach

Author

Garcia MA, Kalecinski J, Oriol M, Bonne A, Lofti M, Espenel S, Tinquaut F, Fournel P, Collard O, Vassal C, Rivoirard R, Regnier V, Chauvin F, and Bourmaud A

Subjects
assessment of needs, patients’ needs, cancer, patient education, mixed qualitative-quantitative method, psychosocial needs, Medicine (General), R5-920
Abstract

Max-Adrien Garcia,1 Julie Kalecinski,1 Mathieu Oriol,1,2 Armand Bonne,1 Mohamed Lofti,1 Sophie Espenel,3 Fabien Tinquaut,1 Pierre Fournel,4 Olivier Collard,4 Cécile Vassal,4 Romain Rivoirard,4 Véronique Regnier,1,5 Franck Chauvin,1,2,5 Aurélie Bourmaud1,5 1Hygee Center, Lucien Neuwirth Cancer Institut, INSERM – CIC-EC, CIC 1408, Saint Priest en Jarez, France; 2Jean Monnet University, Saint Etienne, France; 3Radiotherapy Department, Lucien Neuwirth Cancer Institut, Saint Priest en Jarez, France; 4Medical Oncology Department, Lucien Neuwirth Cancer Institut, Saint Priest en Jarez, France; 5Quality Safety Performance in Health (HESPER) EA7425, Lyon 1 University, Lyon, France Introduction: The announcement of cancer coupled with initiation of its treatment impacts patients’ psychological and physical states as well as their lifestyles. The objective of this study was to identify and confirm the needs of patients starting off on anticancer chemotherapy treatment. Methods: This study was based on a qualitative–quantitative mixed method. In 2009, a qualitative study was conducted at the Lucien Neuwirth Cancer Institut for cancer patients undergoing intravenous chemotherapy for the first time. Exploratory and semi-directed interviews were carried out by a sociologist. In 2014, a questionnaire was hetero-administered to 100 patients starting off on chemotherapy. Results: Forty patients were interviewed in 2009. Ninety-seven patients answered the questionnaire in 2014. Food was a theme that was identified by a majority of patients in 2009 (13/40) and confirmed in 2014: 63% needed help in identifying favorable food and 67% in identifying those that had to be avoided. The other needs identified were those linked to better understanding of the treatment, of how it may affect the couple, its side effects, hygiene and beauty, and knowledge about other treatments. These needs were confirmed in 2014. New needs were elicited in 2014: activities and leisure (33%), psychological needs (32.6%), and family relations (29.9%). Conclusion: This study enabled us to identify, confirm, and enrich our knowledge of the needs of cancer patients starting off on intravenous chemotherapy. These results led to the modification of an existing patient education program for these patients, in order to fulfill their needs in an updated and tailored manner. Keywords: assessment of needs, patients’ needs, cancer, patient education, mixed qualitative–quantitative method, psychosocial needs

Published
2018

26. C3: Efficacité, toxicité et analyse de la qualité de vie de la curiethérapie à débit de dose pulsé du carcinome de la lèvre

Author

Ka, K, primary, El Ayachy, R, additional, Sun, R, additional, Laville, A, additional, Duhamel, AS, additional, Tailleur, A, additional, Dumas, I, additional, Bockel, S, additional, Espenel, S, additional, Blanchard, P, additional, Tao, Y, additional, Temam, S, additional, Moya-Plana, A, additional, Haie-Meder, C, additional, and Chargari, C, additional

Published
2022
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29. PD-0923 Increasing access to highly specialized radiation treatments: the example of pediatric brachytherapy

Author

Chargari, C., primary, Haie-Meder, C., additional, Espenel, S., additional, Ben-Arush, M., additional, Bolle, S., additional, Borjesson, A., additional, Cesen, M., additional, Costa Lago, A., additional, Desfachelles, A., additional, De Moerloose, B., additional, Valck, D., additional, Dos Reis Farinha, N., additional, Francotte, N., additional, Glosli, H., additional, Guillen Burrieza, G., additional, Helfre, S., additional, Irtan, S., additional, Kattamis, A., additional, Lacerda, A., additional, Levy, A., additional, Lyngsie, L., additional, Mansuy, L., additional, Mascard, E., additional, Mlynarski, W., additional, Orbach, D., additional, Owens, C., additional, Philippe-Chomette, P., additional, Peek, A., additional, Pizer, B., additional, Pluchart, C., additional, Rognlien, A.G., additional, Rome, A., additional, Sarnacki, S., additional, Safwat, A., additional, Schiavetti, A., additional, Serre, J., additional, Verite, C., additional, Von der Weid, N., additional, Wendtland, P., additional, Wysocki, M., additional, Valteau-Couanet, D., additional, Deutsch, E., additional, Minard-Colin, V., additional, Martelli, H., additional, and Guérin, F., additional

Published
2021
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31. hTERT Protein Expression in Cytoplasm and Nucleus and its Association With HPV Infection in Patients With Cervical Cancer

Author

Moreno-Acosta, P, Molano, M, Morales, N, Acosta, J, Gonzalez-Prieto, C, Mayorga, D, Buitrago, L, Gamboa, O, Mejia, JC, Castro, J, Romero-Rojas, A, Espenel, S, Murray, GL, Garland, SM, Vallard, A, Magne, N, Moreno-Acosta, P, Molano, M, Morales, N, Acosta, J, Gonzalez-Prieto, C, Mayorga, D, Buitrago, L, Gamboa, O, Mejia, JC, Castro, J, Romero-Rojas, A, Espenel, S, Murray, GL, Garland, SM, Vallard, A, and Magne, N

Abstract

BACKGROUND: Few studies have analyzed the association between human telomerase reverse transcriptase (hTERT) protein expression (nuclear and cytoplasmic localization), hTERT methylation status, and human papillomavirus (HPV) genotype infection in cervical cancer. PATIENTS AND METHODS: One hundred seventy-three patients with cervical cancer were analyzed. hTERT protein expression was detected by immunohistochemistry. hTERT DNA methylation analysis was performed using a PCR-RLB-hTERT assay, targeting two regions of the hTERT promoter. Type specific HPV infection was detected by using GP5+/GP6+PCR-RLB. RESULTS: hTERT protein expression was found in both cytoplasm and nucleus (78.0% of the samples showed a cytoplasmic localization and 79.8% had a nuclear localization). A statistically significant association was found between alpha 9 and 7 HPV species with a non-methylation pattern of the hTERT promoter and between these species and high expression of hTERT protein with nuclear localization. CONCLUSION: hTERT protein is found in both the nucleus and cytoplasm of patients with cervical cancer and confirm the relationship between the non-methylated status of hTERT promoter and some HPV species as well as the relationship between these species and hTERT protein expression.

Published
2020

32. The world of targeted therapies in kidney cancers: pitfalls, tips and tricks

Author

Vallard A, Trone JC, Langrand-Escure J, Espenel S, Guy JB, Rancoule C, Xia YX, El Meddeb Hamrouni A, Ben Mrad M, and Magné N

Subjects
renal cell carcinoma, sunitinib, efficacy, toxicity, sorafenib, bevacizumab, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282
Abstract

Alexis Vallard, Jane-Chloé Trone, Julien Langrand-Escure, Sophie Espenel, Jean-Baptiste Guy, Chloé Rancoule, Yaoxiong Xia, Anis El Meddeb Hamrouni, Majed Ben Mrad, Nicolas Magné Department of Radiation Oncology, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France Abstract: In the past few years, metastatic renal cell carcinoma prognosis was improved by the development of molecular targeted therapies (TTs). At the metastatic stage, the tolerance to treatment is a major concern, not only because of the challenge of the efficacy/toxicity ratio improvement but also because of the importance of an optimal adherence to oral treatments. The present case series relates the issues of dealing with uncommon and sometimes never described side effects of sunitinib and sorafenib. The first case report deals with grade3 vomiting during hemodialysis with concurrent administration of sunitinib. The second case is an iterative gout attack induced by sunitinib. The third case presents a grade 3 scalp dysesthesia with sorafenib. The fourth case includes an astonishing efficacy of metronomic (ie, low doses during a long period of time) bevacizumab in monotherapy. Multidisciplinary management and systematic reporting of unexpected efficacies and toxicities are needed to better understand TTs real therapeutic index. Although TTs revolutionized metastatic renal cell cancer prognosis, they also brought about previously unknown side effects. Identification and management of these off-target effects may be tricky, and therefore, comedication must be wisely chosen. As the physiopathology of these side effects is still unclear, multidisciplinary management and systematic reporting of toxicities are essential. Keywords: renal cell carcinoma, bevacizumab, sunitinib, sorafenib, toxicity, efficacy

Published
2017

34. Harnessing Drug/Radiation Interaction Through Daily Routine Practice: Leverage Medical and Methodological Point of View

Author

Vallard, A., primary, Rancoule, C., additional, Espenel, S., additional, langrand-Escure, J., additional, ben Mrad, M., additional, El Meddeb Hamrouni, A., additional, Trone, J.C., additional, Rehailia Blanchard, A., additional, Guillaume, É., additional, Vial, N., additional, Riocreux, C., additional, Guy, J.B., additional, and Magne, N., additional

Published
2018
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35. Outcomes Prediction in Pre-Operative Radiation Therapy Locally Advanced Rectal Cancer: Leucocyte Assessment as Immune Biomarker

Author

Vallard, A., primary, Garcia, M.A., additional, Espenel, S., additional, Diao, P., additional, Vial, N., additional, Guy, J.B., additional, ben Mrad, M., additional, Rancoule, C., additional, Rehailia Blanchard, A., additional, Pigné, G., additional, Kaczmarek, D., additional, Peoc'h, M., additional, Phelip, J.M., additional, langrand-Escure, J., additional, and Magne, N., additional

Published
2018
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47. HER Family Blockade in Head and Neck Squamous Cell Carcinoma: Couple Therapy Efficacy of Cetuximab and Pertuzumab Combined With Photon Irradiation

Author

Guy, J.B., primary, Méry, B., additional, Rancoule, C., additional, Vallard, A., additional, Espenel, S., additional, Wozny, A.S., additional, Simonet, S., additional, Bernard, D., additional, Ardail, D., additional, Beuve, M., additional, Alphonse, G., additional, Rodriguez-Lafrasse, C., additional, and Magné, N., additional

Published
2016
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48. Denosumab in patients with bone metastases from renal-cell carcinoma treated with anti-angiogenic therapy: a retrospective study from the GETUG (Groupe Etude des Tumeurs Uro Genitales)

Author

Guillot, A., primary, Joly, C., additional, Barthelemy, P., additional, Meriaux, E., additional, Negrier, S., additional, Pouessel, D., additional, Chevreau, C., additional, Mahammedi, H., additional, Houede, N., additional, Roubaud, G., additional, Gravis, G., additional, Tartas, S., additional, Albiges, L., additional, Vassal, C., additional, Oriol, M., additional, Tinquaut, F., additional, Espenel, S., additional, Culine, S., additional, and Fizazi, K., additional

Published
2016
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