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3. Does Size Matter? Animal, Living and Non-Living Classification, Implications for Teaching

Author

Espinoza, Fernando

Abstract

An empirical investigation of elementary school teacher candidates on classification activities dealing with animate and inanimate objects in terms of being living or non-living demonstrates that as the size of the objects increases, subjects are more likely to classify them correctly as either being an animal or having living characteristics. Despite a variety of misconceptions having an impact on the results, size magnitude is shown to play a significant role on proper classification. The subjects' performance on these activities at an advanced stage of their preparation suggests that their factual and procedural knowledge are deficient due to a lack of opportunities for conceptual development of the items tested. The identification of the role of size on the proper classification of objects in the activities bears significantly on the science curricular structure at the elementary school level. As the results of this study indicate, both pre-service elementary school teachers and by extension their prospective students need longer practice dealing with living and non-living classification activities, particularly in tasks where the microscopic features of matter can be investigated so that the proclivity to regard size as the defining characteristic is effectively addressed.

Published
2021

4. Voces indígenas amenazadas y el despertar de sus lenguas

Author

Marleen Haboud Bumachar, Laura Morgenthaler García, Luis Andrade, Marisa Censabella, Franklin Espinoza, Fernando Garcés, Gerardo García, Rosaleen Howard, Brendan Kishketon, Christina Korak, Edith Matías, Rosângela Morello, Fernando Ortega Pérez, Eduardo Pichilingue Ramo, Xosé Luis Regueira, Tulio Rojas Curieux, Cla

Published
2024

5. Impact of Guided Inquiry with Simulations on Knowledge of Electricity and Wave Phenomena

Author

Espinoza, Fernando

Subjects
Physics - Physics Education
Abstract

The impact of inquiry-based instruction on the improvement of content knowledge of electricity and wave properties in two studies was the subject of this investigation. Groups of pre-college and undergraduate students performed a series of tasks designed to determine the effectiveness of exploratory/investigative approaches to the study of wave properties in fostering content retention and conceptual change, as well as in comparison with traditionally performed experimental activities. The results show that a guided inquiry-based method using simulations significantly improves content performance on electricity and wave motion, although not in optics; in particular, it helps students to visualize charge exchanges and electric neutrality, the shape of electric fields, types of waves and their characteristics, and the effects of the transmitting medium on the speed of a wave. Additionally, its exploratory nature is superior to the confirmatory laboratory experience, both in content retention and in facilitating the incorporation of perceptual features that help learners deal with documented challenging properties of waves.

Published
2020
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6. Zanclospora bicolorata sp. nov. from Ecuador

Author

Villavicencio, Mirian, Sosa, Daynet, Vera, Marcos, Espinoza, Fernando, Quevedo, Adela, Magdama, Freddy, Serrano, Lizette, Pérez-Martínez, Simón, Castañeda Ruiz, Rafael F., and BioStor

Published
2020

7. Beltrania nodulosa sp. nov. from Ecuador

Author

Quevedo, Adela, Sosa, Daynet, Vera, Marcos, Espinoza, Fernando, Magdama, Freddy, Serrano, Lizette, Villavicencio, Mirian, Castañeda Ruiz, Rafael F., and BioStor

Published
2020

8. Similitrichoconis wongii gen. & sp. nov. from Ecuador

Author

Vera, Marcos, Sosa, Daynet, Magdama, Freddy, Quevedo, Adela, Espinoza, Fernando, Serrano, Lizette, Villavicencio, Mirian, Choez-Guaranda, Ivan, Pérez-Martínez, Simón, Castañeda Ruiz, Rafael F., and BioStor

Published
2020

9. Bactrodesmium pulcherrimum sp. nov. from Ecuador

Author

Espinoza, Fernando, Sosa, Daynet, Serrano, Lizette, Quevedo, Adela, Magdama, Freddy, Vera, Marcos, Pérez-Martínez, Simón, Malosso, Elaine, Castañeda Ruiz, Rafael F., and BioStor

Published
2020

10. Guayaquilia gen. nov., typified by Idriella cubensis

Author

Magdama, Freddy, Sosa, Daynet, Espinoza, Fernando, Serrano, Lizette, Pérez-Martínez, Simón, Malosso, Elaine, Hernández-Restrepo, Margarita, Castañeda Ruiz, Rafael F., and BioStor

Published
2020

11. Neomyrmecridium asymmetricum sp. nov. from Ecuador

Author

Serrano, Lizette, Sosa, Daynet, Magdama, Freddy, Espinoza, Fernando, Quevedo, Adela, Vera, Marcos, Villavicencio, Miriam, Maridueña, Gabriela, Pérez-Martínez, Simón, Malosso, Elaine, Ramos-García, Beatriz, Castañeda Ruiz, Rafael F., and BioStor

Published
2020

17. A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models

Author

Yagiz, Kader, Rodriguez-Aguirre, Maria E, Espinoza, Fernando Lopez, Montellano, Tiffany T, Mendoza, Daniel, Mitchell, Leah A, Ibanez, Carlos E, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, and Robbins, Joan M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Brain Cancer, Rare Diseases, Brain Disorders, Cancer, Digestive Diseases, Colo-Rectal Cancer, Neurosciences, 5-FU, MDSC, chemoimmunotherapy, durable response, immunotherapy, mCRC, retroviral vector
Abstract

Treatment of tumors with Toca 511, a gamma retroviral replicating vector encoding cytosine deaminase, followed by 5-fluorocytosine (5-FC) kills tumors by local production of 5-fluorouracil (5-FU). In brain tumor models, this treatment induces systemic anti-tumor immune responses and long-term immune-mediated survival. Phase 1 Toca 511 and Toca FC (extended-release 5-FC) clinical trials in patients with recurrent high-grade glioma show durable complete responses and promising survival data compared to historic controls. The work described herein served to expand on our earlier findings in two models of metastatic colorectal carcinoma (mCRC). Intravenous (i.v.) delivery of Toca 511 resulted in substantial tumor-selective uptake of vector into metastatic lesions. Subsequent treatment with 5-FC resulted in tumor shrinkage, improved survival, and immune memory against future rechallenge with the same CT26 CRC cell line. Similar results were seen in a brain metastasis model of mCRC. Of note, 5-FC treatment resulted in a significant decrease in myeloid-derived suppressor cells (MDSCs) in mCRC tumors in both the liver and brain. These results support the development of Toca 511 and Toca FC as a novel immunotherapeutic approach for patients with mCRC. A phase 1 study of i.v. Toca 511 and Toca FC in solid tumors, including mCRC, is currently underway (NCT02576665).

Published
2018

18. Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model

Author

Mitchell, Leah A, Espinoza, Fernando Lopez, Mendoza, Daniel, Kato, Yuki, Inagaki, Akihito, Hiraoka, Kei, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, and Robbins, Joan M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Brain Cancer, Rare Diseases, Brain Disorders, Animals, Antineoplastic Agents, Brain Neoplasms, Cell Line, Tumor, Cytosine Deaminase, Disease Models, Animal, Flucytosine, Genetic Therapy, Genetic Vectors, Glioma, Immunity, Mice, Monocytes, Myeloid Cells, Prodrugs, Retroviridae, T-Lymphocytes, 5-fluorouracil, cytosine deaminase, immunotherapy, myeloid-derived suppressor cell, retroviral gene transfer, Neurosciences, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundToca 511 (vocimagene amiretrorepvec) is a retroviral replicating vector encoding an optimized yeast cytosine deaminase (CD). Tumor-selective expression of CD converts the prodrug, 5-fluorocytosine (5-FC), into the active chemotherapeutic, 5-fluorouracil (5-FU). This therapeutic approach is being tested in a randomized phase II/III trial in recurrent glioblastoma and anaplastic astrocytoma (NCT0241416). The aim of this study was to identify the immune cell subsets contributing to antitumor immune responses following treatment with 5-FC in Toca 511-expressing gliomas in a syngeneic mouse model.MethodsFlow cytometry was utilized to monitor and characterize the immune cell infiltrate in subcutaneous Tu-2449 gliomas in B6C3F1 mice treated with Toca 511 and 5-FC.ResultsTumor-bearing animals treated with Toca 511 and 5-FC display alterations in immune cell populations within the tumor that result in antitumor immune protection. Attenuated immune subsets were exclusive to immunosuppressive cells of myeloid origin. Depletion of immunosuppressive cells temporally preceded a second event which included expansion of T cells which were polarized away from Th2 and Th17 in the CD4+ T cell compartment with concomitant expansion of interferon gamma-expressing CD8+ T cells. Immune alterations correlated with clearance of Tu-2449 subcutaneous tumors and T cell-dependent protection from future tumor challenge.ConclusionsTreatment with Toca 511 and 5-FC has a concentrated effect at the site of the tumor which causes direct tumor cell death and alterations in immune cell infiltrate, resulting in a tumor microenvironment that is more permissive to establishment of a T cell mediated antitumor immune response.

Published
2017

19. Phytochemical profiling, antioxidant, enzymatic inhibitory, and antibacterial activities of Wigandia ecuadorensis.

Author

Viteri, Rafael, Espinoza, Fernando, Cornejo, Xavier, Simirgiotis, Mario J., and Manzano, Patricia

Subjects
ESCHERICHIA coli, METABOLITES, PHENOLIC acids, ANTIBACTERIAL agents, BUTYRYLCHOLINESTERASE, ETHYL acetate
Abstract

Wigandia ecuadoriensis , a member of the Namaceae family, is a source of metabolites and has been traditionally used as an anti-inflammatory. This work aimed to determine the total phenolic content (TPC), total flavonoid content (TFC), antioxidant effect, inhibition of α-glucosidase and cholinesterase enzymes (AChE, BChE), and antibacterial activity of the methanolic extract (ME) and subfractions of Wigandia ecuadoriensis. The findings revealed that ME and its subfractions exhibited significant antioxidant capacity, with the ethyl acetate fraction being the most active, displaying an IC50 of 17.66 µg/mL against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 10.31 µg/mL against 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS). This activity was attributed to its high total phenolic content (357.47 mg GAE/g). Furthermore, W. ecuadoriensis fractions showed marked antimicrobial properties against human pathogen strains with Minimum Bactericidal Concentration (MBC) values ​​of 1.56–6.25 mg/mL for S. aureus , E. faecalis and E. coli. Furthermore, aqueous fraction exhibited slight inhibition of acetylcholinesterase (IC50: 915.98 µg/mL) and butyrylcholinesterase (IC50: 380.42 µg/mL). Interestingly, EF showed the greatest inhibitory effect of α-glucosidase (IC50: 38.44 µg/mL) which is more potent than the control used, acarbose (IC50: 179.07 µg/mL). UHPLC-QTOF-MS analysis identified forty compounds, including phenolic acids, flavonoids, saponins, terpenes, and fatty acyls. As far as we know, this is the first study to evaluate the chemical composition and biological potential of W. ecuadoriensis. Our results provide the first evidence to the chemical knowledge of the species W. ecuadoriensis and demonstrate its bioactive potential as an interesting source of secondary metabolites with possible beneficial properties for health. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Intravenous Administration of Retroviral Replicating Vector, Toca 511, Demonstrates Therapeutic Efficacy in Orthotopic Immune-Competent Mouse Glioma Model

Author

Huang, Tiffany T, Parab, Shraddha, Burnett, Ryan, Diago, Oscar, Ostertag, Derek, Hofman, Florence M, Espinoza, Fernando Lopez, Martin, Bryan, Ibañez, Carlos E, Kasahara, Noriyuki, Gruber, Harry E, Pertschuk, Daniel, Jolly, Douglas J, and Robbins, Joan M

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Immunology, Gene Therapy, Genetics, Cancer, Rare Diseases, Brain Cancer, Neurosciences, Brain Disorders, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Animals, Antibodies, Neutralizing, Antimetabolites, Brain Neoplasms, Clinical Trials as Topic, Cytosine Deaminase, Disease Models, Animal, Drug Evaluation, Preclinical, Flucytosine, Fungal Proteins, Gene Expression, Genes, Reporter, Genetic Therapy, Genetic Vectors, Glioma, Green Fluorescent Proteins, Humans, Injections, Intravenous, Mice, Mice, Nude, Recombinant Proteins, Retroviridae, Survival Analysis, Tissue Distribution, Clinical Sciences, Biotechnology, Medical biotechnology
Abstract

Toca 511 (vocimagene amiretrorepvec), a nonlytic, amphotropic retroviral replicating vector (RRV), encodes and delivers a functionally optimized yeast cytosine deaminase (CD) gene to tumors. In orthotopic glioma models treated with Toca 511 and 5-fluorocytosine (5-FC) the CD enzyme within infected cells converts 5-FC to 5-fluorouracil (5-FU), resulting in tumor killing. Toca 511, delivered locally either by intratumoral injection or by injection into the resection bed, in combination with subsequent oral extended-release 5-FC (Toca FC), is under clinical investigation in patients with recurrent high-grade glioma (HGG). If feasible, intravenous administration of vectors is less invasive, can easily be repeated if desired, and may be applicable to other tumor types. Here, we present preclinical data that support the development of an intravenous administration protocol. First we show that intravenous administration of Toca 511 in a preclinical model did not lead to widespread or uncontrolled replication of the RVV. No, or low, viral DNA was found in the blood and most of the tissues examined 180 days after Toca 511 administration. We also show that RRV administered intravenously leads to efficient infection and spread of the vector carrying the green fluorescent protein (GFP)-encoding gene (Toca GFP) through tumors in both immune-competent and immune-compromised animal models. However, initial vector localization within the tumor appeared to depend on the mode of administration. Long-term survival was observed in immune-competent mice when Toca 511 was administered intravenously or intracranially in combination with 5-FC treatment, and this combination was well tolerated in the preclinical models. Enhanced survival could also be achieved in animals with preexisting immune response to vector, supporting the potential for repeated administration. On the basis of these and other supporting data, a clinical trial investigating intravenous administration of Toca 511 in patients with recurrent HGG is currently open and enrolling.

Published
2015

36. Whole genome sequencing of nine Vibrio parahaemolyticus strains encoding ( Pir ) toxin-like genes from shrimp cultures in northern Peru using Oxford Nanopore technology

Author

Tapia-Chirinos, Stephanie, primary, Salcedo-Mejia, Luis Alberto, additional, Domínguez-Mendoza, Luz, additional, Nuñure-Ortega, Jeferson, additional, Ramos-Espinoza, Fernando, additional, Gómez-Sánchez, Muriel, additional, Tataje-Lavanda, Luis, additional, and Velazco-Peña, Rodolfo, additional

Published
2024
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38. Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Author

Bhangu, Aneel, Ademuyiwa, Adesoji O, Aguilera, Maria Lorena, Alexander, Philip, Al-Saqqa, Sara W, Borda-Luque, Giuliano, Costas-Chavarri, Ainhoa, Drake, Thomas M, Ntirenganya, Faustin, Fitzgerald, J Edward, Fergusson, Stuart J, Glasbey, James, Ingabire, JC Allen, Ismaïl, Lawani, Salem, Hosni Khairy, Kojo, Anyomih Theophilus Teddy, Lapitan, Marie Carmela, Lilford, Richard, Mihaljevic, Andre L, Morton, Dion, Mutabazi, Alphonse Zeta, Nepogodiev, Dmitri, Adisa, Adewale O, Ots, Riinu, Pata, Francesco, Pinkney, Thomas, Poškus, Tomas, Qureshi, Ahmad Uzair, Ramos-De la Medina, Antonio, Rayne, Sarah, Shaw, Catherine A, Shu, Sebastian, Spence, Richard, Smart, Neil, Tabiri, Stephen, Harrison, Ewen M, Khatri, Chetan, Mohan, Midhun, Jaffry, Zahra, Altamini, Afnan, Kirby, Andrew, Søreide, Kjetil, Recinos, Gustavo, Cornick, Jen, Modolo, Maria Marta, Iyer, Dushyant, King, Sebastian, Arthur, Tom, Nahar, Sayeda Nazmum, Waterman, Ade, Walsh, Michael, Agarwal, Arnav, Zani, Augusto, Firdouse, Mohammed, Rouse, Tyler, Liu, Qinyang, Correa, Juan Camilo, Talving, Peep, Worku, Mengistu, Arnaud, Alexis, Kalles, Vassilis, Kumar, Basant, Kumar, Sunil, Amandito, Radhian, Quek, Roy, Ansaloni, Luca, Altibi, Ahmed, Venskutonis, Donatas, Zilinskas, Justas, Poskus, Tomas, Whitaker, John, Msosa, Vanessa, Tew, Yong Yong, Farrugia, Alexia, Borg, Elaine, Bentounsi, Zineb, Gala, Tanzeela, Al-Slaibi, Ibrahim, Tahboub, Haya, Alser, Osaid H, Romani, Diego, Shu, Sebestian, Major, Piotr, Mironescu, Aurel, Bratu, Matei, Kourdouli, Amar, Ndajiwo, Aliyu, Altwijri, Abdulaziz, Alsaggaf, Mohammed Ubaid, Gudal, Ahmad, Jubran, Al Faifi, Seisay, Sam, Lieske, Bettina, Ortega, Irene, Jeyakumar, Jenifa, Senanayake, Kithsiri J, Abdulbagi, Omar, Cengiz, Yucel, Raptis, Dmitri, Altinel, Yuksel, Kong, Chia, Teasdale, Ella, Irwin, Gareth, Stoddart, Michael, Kabariti, Rakan, Suresh, Sukrit, Gash, Katherine, Narayanan, Ragavan, Maimbo, Mayaba, Grizhja, Besmir, Ymeri, Shpetim, Galiqi, Gezim, Klappenbach, Roberto, Antezana, Diego, Mendoza Beleño, Alvaro Enrique, Costa, Cecilia, Sanchez, Belen, Aviles, Susan, Fermani, Claudio Gabriel, Balmaceda, Rubén, Villalobos, Santiago, Carmona, Juan Manuel, Hamill, Daniel, Deutschmann, Peter, Sandler, Simone, Cox, Daniel, Nataraja, Ram, Sharpin, Claire, Ljuhar, Damir, Gray, Demi, Haines, Morgan, Iyer, Dush, Niranjan, Nithya, D'Amours, Scott, Ashtari, Morvarid, Franco, Helena, Rahman Mitul, Ashrarur, Karim, Sabbir, Aman, Nowrin F, Estee, Mahnuma Mahfuz, Salma, Umme, Razzaque, Joyeta, Hamid Kanta, Tasnia, Tori, Sayeeda Aktar, Alamin, Shadid, Roy, Swapnil, Al Amin, Shadid, Karim, Rezaul, Haque, Muhtarima, Faruq, Amreen, Iftekhar, Farhana, O'Shea, Margaret, Padmore, Greg, Jonnalagadda, Ramesh, Litvin, Andrey, Filatau, Aliaksandr, Paulouski, Dzmitry, Shubianok, Maryna, Shachykava, Tatsiana, Khokha, Dzianis, Khokha, Vladimir, Djivoh, Fernande, Dossou, Francis, Seto, Djifid Morel, Gbessi, Dansou Gaspard, Noukpozounkou, Bruno, Imorou Souaibou, Yacoubou, Keke, Kpèmahouton René, Hodonou, Fred, Ahounou, Ernest Yemalin Stephane, Alihonou, Thierry, Dénakpo, Max, Ahlonsou, Germain, Ginbo Bedada, Alemayehu, Nsengiyumva, Carlos, Kwizera, Sandrine, Barendegere, Venerand, Choi, Philip, Stock, Simon, Jamal, Luai, Azzie, Georges, Kushwaha, Sameer, Chen, Tzu-Ling, Yip, Chingwan, Montes, Irene, Zapata, Felipe, Sierra, Sebastian, Villegas Lanau, Maria Isabel, Mendoza Arango, Maria Clara, Mendoza Restrepo, Ivan, Restrepo Giraldo, Ruben Santiago, Domini, Edgar, Karlo, Robert, Mihanovic, Jakov, Youssef, Mohamed, Elfeki, Hossam, Thabet, Waleed, Sanad, Aly, Tawfik, Gehad, Zaki, Ahmed, Abdel-Hameed, Noran, Mostafa, Mohamed, Omar, Muhammad Fathi Waleed, Ghanem, Ahmed, Abdallah, Emad, Denewer, Adel, Emara, Eman, Rashad, Eman, Sakr, Ahmad, Elashry, Rehab, Emile, Sameh, Khafagy, Toqa, Elhamouly, Sara, Elfarargy, Arwa, Mamdouh Mohamed, Amna, Saied Nagy, Ghada, Esam, Abeer, Elwy, Eman, Hammad, Aya, Khallaf, Salwa, Ibrahim, Eman, Said Badr, Ahmed, Moustafa, Ahmed, Eldosouky Mohammed, Amany, Elgheriany, Mohammed, Abdelmageed, Eman, Al Raouf, Eman Abd, Samir Elbanby, Esraa, Elmasry, Maha, Morsy Farahat, Mahitab, Yahya Mansor, Eman, Magdy Hegazy, Eman, Gamal, Esraa, Gamal, Heba, Kandil, Hend, Maher Abdelrouf, Doaa, Moaty, Mohamed, Gamal, Dina, El-Sagheer, Nada, Salah, Mohamed, Magdy, Salma, Salah, Asmaa, Essam, Ahmed, Ali, Ahmed, Badawy, Mahmoud, Ahmed, Sara, Mohamed, Mazed, Assal, Abdelrahman, Sleem, Mohamed, Ebidy, Mai, Abd-Elrazek, Aly, Zahran, Diaaaldin, Adam, Nourhan, Nazir, Mohamed, Hassanein, Adel B, Ismail, Ahmed, Elsawy, Amira, Mamdouh, Rana, Mabrouk, Mohamed, Ahmed, Lopna Ahmed Mohamed, Hassab Alnaby, Mohamed, Magdy, Eman, Abd-Elmawla, Manar, Fahim, Marwan, Mowafy, Bassant, Ibrahim Mahmoud, Moustafa, Allam, Meran, Alkelani, Muhammad, Halim El Gendy, Noran, Saad Aboul-Naga, Mariam, Alaa El-Din, Reham, Elgendy, Alyaa Halim, Ismail, Mohamed, Shalaby, Mahmoud, Adel Elsharkawy, Aya, Elsayed Moghazy, Mahmoud, Hesham Elbisomy, Khaled, Abdel Gawad Shakshouk, Hend, Hamed, Mohamed Fouad, Ebidy, Mai Mohamed, Abdelkader, Mostafa, Karkeet, Mohamed, Ahmed, Hayam, Adel, Israa, Omar, Mohammad Elsayed, Ibrahim, Mohamed, Ghoneim, Omar, Hesham, Omar, Gamal, Shimaa, Hilal, Karim, Arafa, Omar, Adel Awad, Sawsan, Salem, Menatalla, Abdellatif Elsherif, Fawzia, Elsabbagh, Nourhan, Aboelsoud, Moustafa R, Hossam Eldin Fouad Rida, Ahmed, Hossameldin, Amr, Hany, Ethar, Hosny Asar, Yomna, Anwar, Nourhan, Gadelkarim, Mohamed, Abdelhady, Samar, Mohamed Morshedy, Eman, Saad, Reham, Soliman, Nourhan, Salama, Mahmoud, Ezzat, Eslam, Mohamed, Arwa, Ibrahim, Arwa, Fergany, Alaa, Mohammed, Sara, Reda, Aya, Allam, Yomna, Saad, Hanan Adel, Abdelfatah, Afnan, Fathy, Aya Mohamed, El-Sehily, Ahmed, Abdalmageed Kasem, Esraa, Hassan, Ahmed Tarek Abdelbaset, Mohammed, Ahmed Rabeih, Saad, Abdalla Gamal, Elfouly, Yasmin, Elfouly, Nesma, Ibrahim, Arij, Hassaan, Amr, Mohammed, Mohammed Mustafa, Elhoseny, Ghada, Magdy, Mohamed, Abd Elkhalek, Esraa, Zakaria, Yehia, Ezzat, Tarek, Abo El Dahab, Ali, Kelany, Mohamed, Arafa, Sara, Mokhtar Mohamed Hassan, Osama, Mohamed Badwi, Nermin, Saber Sleem, Ahmad, Ahmed, Hussien, Abdelbadeai, Kholoud, Abozed Abdullah, Mohamed, Lokman, Muhammad Amsyar Auni, Bahar, Suraya, Rady Abdelazeam, Anan, Adelshone, Abdelrahman, Bin Hasnan, Muhammad, Zulkifli, Athirah, Kamarulzamil, Siti Nur Alia, Elhendawy, Abdelaziz, Latif, Aliang, Bin Adnan, Ahmad, Shaharuddin, Shahadatul, Haji Abdul Majid, Aminah Hanum, Amreia, Mahmoud, Al-Marakby, Dina, Salma, Mahmoud, Ismail, Mohamad Jeffrey Bin, Mohd Basir, Elissa Rifhan, Mohd Ali, Citra Dewi, Ata, Aya Yehia, Nasr, Maha, Rezq, Asmaa, Sheta, Ahmed, Tariq, Sherif, Sallam, Abd Elkhalek, Darwish, Abdelrhman KZ, Elmihy, Sohaila, Elhadry, Shady, Farag, Ahmed, Hajeh, Haidar, Abdelaal, Abdelaziz, Aglan, Amro, Zohair, Ahmed, Essam, Mahitab, Moussa, Omar, El-Gizawy, Esraa, Samy, Mostafa, Ali, Safia, El Halawany, Esraa, Ata, Ahmed, El Halawany, Mohamed, Nashat, Mohamed, Soliman, Samar, Elazab, Alaa, Samy, Mostada, Abdelaziz, Mohamed A, Ibrahim, Khaled, Ibrahim, Ahmed Mohamed, Gado, Ammar, Hantour, Usama, Alm Eldeen, Esraa, Loaloa, Mohamed Reda, Abouzaid, Arwa, Ahmed Bahaa Eldin, Mostafa, Hashad, Eman, Sroor, Fathy, Gamil, Doaa, Mahmoud Abdulhakeem, Eman, Zakaria, Mahmoud, Mohamed, Fawzy, Abubakr, Marwan, Ali, Elsayed, Magdy, Hesham, Ramadan, Menna Tallah, Abdelaty Mohamed, Mohamed, Mansour, Salma, Abdul Aziz Amin, Hager, Rabie Mohamed, Ahmed, Saami, Mahmoud, Ahmed Reda Elsayed, Nada, Tarek, Adham, Mohy Eldeen Mahmoud, Sabry, Magdy El Sayed, Islam, Reda, Amira, Yusuf Shawky, Martina, Mousa Salem, Mohammed, Alaa El-Din, Shahinaz, Abdullah Soliman, Noha, Talaat, Muhammed, Alaael-Dein, Shahinaz, Abd Elmoen Elhusseiny, Ahmed, Abdullah, Noha, Elshaar, Mohammed, Abdelfatah Ibraheem, Aya, Abdulaziz, Hager, Kamal Ismail, Mohammed, Hamdy Madkor, Mona, Abdelaty, Mohamed, Mahmoud Abdel-Kader, Sara, Mohamed Salah, Osama, Eldafrawy, Mahmoud, Zaki Eldeeb, Ahmed, Mahmoud Eid, Mostafa, Attia, Attia, Salah El-Dien, Khalid, Shwky, Ayman, Badenjki, Mohamed Adel, Soliman, Abdelrahman, Mahmoud Al Attar, Samaa, Sayed, Farrag, Abdel Sabour, Fahd, Azizeldine, Mohammed G, Shawqi, Muhammad, Hashim, Abdullah, Aamer, Ahmed, Abdelraouf, Ahmed Mahmoud, Abdelshakour, Mahmoud, Ibrahim, Amal, Mahmoud, Basma, Ali Mahmoud, Mohamed, Qenawy, Mostafa, Rashed, Ahmed M, Dahy, Ahmed, Sayed, Marwa, Shamsedine, Ahmed W, Mohamed, Bakeer, Hasan, Ahmad, Saad, Mahmoud M, Abdul Bassit, Khalil, Khalid Abd El-Latif, Nadia, Elzahed, Nada, El Kashash, Ahmed, Bekhet, Nada Mohamed, Hafez, Sarah, Gad, Ahmed, Maher, Mahmoud Elkhadragy, Abd El-Sameea, Ahmed, Hafez, Mohamed, Sabe, Ahmad, Ahmed, Ataa, Shahine, Ahmed, Dawood, Khaled, Gaafar, Shireen, Husseiny, Reem, Aboelmagd, Omnia, Soliman, Ahmed, Mesbah, Nourhan, Emadeldin, Hossam, Al Meligy, Amgad, Bekhet, Amira Hassan, Hasan, Doaa, Alhady, Khaled, Sabe, Ahmad Khaled, Elnajjar, Mahmoud A, Aboelella, Majed, Hamsho, Ward, Hassan, Ihab, Saad, Hala, Abdelazim, Galaleldin, Mahmoud, Hend, Wael, Noha, Kandil, Ahmedali M, Magdy, Ahmed, Said Elkholy, Shimaa, Adel, Badr Eldin, Dabbour, Kareem, Elsherbiney, Saged, Mattar, Omar, Khaled AbdRabou, Abdulshafi, Aly, Mohammed Yahia Mohamed, Geuoshy, Abdelrahman, Elnagar, Ahmedglal, Ahmed, Saraibrahim, Abdelmotaleb, Ibrahem, Saleh, Amr Ahmed, Mohammed Bakry, Hesham, Saeed, Manar, Mahmoud, Shady, Tawfik, Badreldin Adel, Ismail, Samar Adel, Zakaria, Esraay, Gad, Mariam O, Salah Elhelbawy, Mohamed, Bassem, Monica, Maraie, Noha, Medhat Elhadary, Nourhan, Semeda, Nourhan, Rabie Mohamed, Shaza, Bakry, Hesham Mohammed, Essam, AA, Tarek, Dina, Ashour, Khlood, Elhadad, Alaa, Abdel-Aty, Abdulrahman, Rakha, Ibrahim, Mamdouh Matter, Sara, Abdelhamed, Rasha, Abdelkader, Omar, Hassaan, Ayat, Soliman, Yasmin, Mohamed, Amna, Ghanem, Sara, Amr Mohamed Farouk, Sara, Ibrahim, Eman Mohamed, El-Taher, Esraa, Mostafa, Merna, Mahrous Badr, Mohamed Fawzy, Elsemelawy, Rofida, El-Sawy, Aya, Bakr, Ahmad, Al Rafati, Ahmad Abdel 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Badicel, Maria, Jaich, Robert, Ruiz-Tovar, Jaime, Garcia-Florez, Luis, Otero-Díez, Jorge L, Ramos Pérez, Virginia, Aguado Suárez, Nuria, Minguez García, Javier, Corral Moreno, Sara, Collado, Maria Vicenta, Jiménez Carneros, Virginia, García Septiem, Javier, Gonzalez, Mariana, Picardo, Antonio, Esteban, Enrique, Ferrero, Esther, Espin-Basany, Eloy, Blanco-Colino, Ruth, Andriola, Valeria, Solar García, Lorena, Contreras, Elisa, García Bernardo, Carmen, Pagnozzi, Janet, Sanz, Sandra, Miyar de León, Alberto, Dorismé, Asnel, Rodicio, Joseluis, Suarez, Aida, Stuva, Jessica, Diaz Vico, Tamara, Fernandez-Vega, Laura, Soldevila-Verdeguer, Carla, Sena-Ruiz, Fatima, Pujol-Cano, Natalia, Diaz-Jover, Paula, Garcia-Perez, José Maria, Segura-Sampedro, Juan Jose, Pineño-Flores, Cristina, Ambrona-Zafra, David, Craus-Miguel, Andrea, Jimenez-Morillas, Patricia, Mazzella, Angela, Jayathilake, AB, Thalgaspitiya, SPB, Wijayarathna, LS, Wimalge, PMSN, Sanni, Hakeem Ayomi, Okenabirhie, Ogheneochuko, Homeida, Anmar, Younis, Abobaker, Omer, Omer Abdelbagi, Abdulaziz, Mustafa, Mussad, Ali, Adam, Ali, Björklund, Ida, Ahlqvist, Sandra, Thorell, Anders, Wogensen, Fredrik, Sokratous, Arestis, Breistrand, Michaela, Thorarinsdottir, Hildur, Sigurdadottir, Johanna, Nikberg, Maziar, Chabok, Abbas, Hjertberg, Maria, Elbe, Peter, Saraste, Deborah, Rutkowski, Wiktor, Forlin, Louise, Niska, Karoliina, Sund, Malin, Oswald, Dennis, Peros, Georgios, Bluelle, Rafael, Reinisch, Katharina, Frey, Daniel, Palma, Adrian, Raptis, Dimitri Aristotle, Zumbühl, Lucius, Zuber, Markus, Schmid, Roger, Werder, Gabriela, Nocito, Antonio, Gerosa, Alexandra, Mahanty, Silke, Widmer, Lukas Werner, Müller, Julia, Gübeli, Alissa, Zuk, Grzegorz, Gulcicek, Osman Bilgin, Vartanoglu, Talar, Kose, Emin, Karahan, Servet Rustu, Aydin, Mehmet Can, Sahbaz, Nuri Alper, Halicioglu, Ilkay, Alis, Halil, Sapci, Ipek, Adiyaman, Can, Pektaş, Ahmet Murat, Cengiz, Turgut Bora, Tansoker, Ilkan, Işler, Vedatcan, Cevik, Muazzez, Mutlu, Deniz, Ozben, Volkan, Ozmen, Berk Baris, Bayram, Sefa, Yolcu, Sinem, Kobal, Berna Buse, Toto, Ömer Faruk, Çakaloğlu, Haluk Cem, Karabulut, Kagan, Mutlu, Vahit, Ozkan, Bahar Busra, Celik, Saban, Semiz, Anil, Bodur, Selim, Gül, Enisburak, Murutoglu, Busra, Yildirim, Reyyan, Baki, Bahadir Emre, Arslan, Ekin, Ulusahin, Mehmet, Guner, Ali, Tomas, Kudir, Walker, Nathan, Shrimanker, Nikhita, Cole, Simon, Breslin, Ryan, Srinivasan, Ravi, Elshaer, Mohamed, Hunter, Kristina, Al-Bahrani, Ahmed, Liew, Ignatius, Mairs, Nora Grace, Rocke, Alistair, Dick, Lachlan, Qureshi, Mobeen, Chowdhury, Debkumar, Wright, Naomi, Skerritt, Clare, Kufeji, Dorothy, Ho, Adrienne, Dissanayake, Tharindra, Tennakoon, Athula, Ali, Wadah, Lim, Shujing Jane, Tan, Charlene, O'Neill, Stephen, Jones, Catrin, Knight, Stephen, Nassif, Dima, Sharma, Abhishek, Warren, Oliver, White, Rebecca, Mehdi, Aia, Post, Nathan, Kalakouti, Eliana, Dashnyam, Enkhbat, Stourton, Frederick, Mykoniatis, Ioannis, Currow, Chelise, Wong, Francisca, Gupta, Ashish, Shatkar, Veeranna, Luck, Joshua, Kadiwar, Suraj, Smedley, Alexander, Wakefield, Rebecca, Herrod, Philip, Blackwell, James, Lund, Jonathan, Cohen, Fraser, Bandi, Ashwath, Giuliani, Stefano, Bond-Smith, Giles, Pezas, Theodore, Farhangmehr, Neda, Urbonas, Tomas, Perenyei, Miklos, Ireland, Philip, Blencowe, Natalie, Bowling, Kirk, Bunting, David, Longstaff, Lydia, Keogh, Kenneth, Jeon, Hyunjin, Iqbal, Muhammad Rafaih, Khosla, Shivun, Jeffery, Anna, Perera, James, Ibrahem, Ahmad Aboelkassem, Alhammali, Tariq, Salama, Yahya, Oram, Shaun, Kidd, Thomas, Cullen, Fraser, Owen, Christopher, Wilson, Michael, Chiu, Seehui, Sarafilovic, Hannah, Ploski, Jennifer, Evans, Elizabeth, Abbas, Athar, Kamya, Sylvia, Ishak, Norzawani, Bisset, Carly, Andress, Cedar, Chin, Ye Ru, Patel, Priya, Evans, David, Haslegrave, Aidan, Boggon, Adam, Laurie, Kirsten, Connor, Katie, Mann, Thomas, Mansuri, Anahita, Davies, Rachel, Griffiths, Ewen, Shahbaz, Aized Raza, Eng, Calvin, Din, Farhat, L'Heveder, Ariadne, Park, Esther HG, Ravishankar, Ramanish, McIntosh, Kirsten, Yau, Jih Dar, Chan, Luke, McGarvie, Susan, Tang, Lingshan, Lim, Hui, Yap, Suhhuey, Park, Jay, Ng, Zhan Herr, Mirza, Shahrukh, Ang, Yun Lin, Walls, Luke, Roy, Chloe, Paterson-Brown, Simon, Camilleri-Brennan, Julian, Mclean, Kenneth, D'Souza, Michelle S, Pronin, Savva, Henshall, David Ewart, Ter, Eunice Zuling, Fouad, Dina, Minocha, Ashish, English, William, Morgan, Catrin, Townsend, Dominic, Maciejec, Laura, Mahdi, Shareef, Akpenyi, Onyinye, Hall, Elisabeth, Caydiid, Hanaan, Rob, Zakaria, Abbott, Tom, Torrance, Hew D, Johnston, Robin, Gani, Mohammed Aki, Gravante, Gianpiero, Rajmohan, Shivanchan, Majid, Kiran, Dindyal, Shiva, Smith, Christopher, Palliyil, Madanmohan, Patel, Sanjay, Nicholson, Luke, Harvey, Neil, Baillie, Katie, Shillito, Sam, Kershaw, Suzanne, Bamford, Rebecca, Orton, Peter, Reunis, Elke, Tyler, Robert, Soon, Wai Cheong, Jama, Guled M, Dhillon, Dharminder, Patel, Khyati, Nanthakumaran, Shayanthan, Heard, Rachel, Chen, Kar Yan, Barmayehvar, Behrad, Datta, Uttaran, Kamarajah, Sivesh K, Karandikar, Sharad, Iftekhar Tani, Sobhana, Monaghan, Eimear, Donnelly, Philippa, Walker, Michael, Parakh, Jehangirshaw, Blacker, Sarah, Kaul, Anil, Paramasivan, Arjun, Farag, Sameh, Nessa, Ashrafun, Awadallah, Salwa, Lim, Jieqi, Chean Khun Ng, James, Kiran, Ravi P, Murray, Alice, Etchill, Eric, Dasari, Mohini, Puyana, Juan, Haddad, Nadeem, Zielinski, Martin, Choudhry, Asad, Caliman, Celeste, Beamon, Mieshia, Duane, Therese, Swaroop, Mamta, Myers, Jonathan, Deal, Rebecca, Schadde, Erik, Hemmila, Mark, Napolitano, Lena, To, Kathleen, Makupe, Alex, Musowoya, Joseph, van der Naald, Niels, Kumwenda, Dayson, Reece-Smith, Alex, Otten, Kars, Verbeek, Anna, Prins, Marloes, Baquero Suarez, Alibeth Andres, Balmaceda, Ruben, Deane, Chelsea, Dijan, Emilio, Elfiky, Mahmoud, Koskenvuo, Laura, Thollot, Aurore, Limoges, Bernard, Capito, Carmen, Alexandre, Challine, Kotobi, Henri, Leroux, Julien, Pinnagoda, Kalitha, Henric, Nicolas, Azzis, Olivier, Rosello, Olivier, Francois, Poddevin, Etienne, Sara, Buisson, Philippe, Hmila, Sophian, Clegg-Lamptey, Joe-Nat, Imoro, Osman, Abem, Owusu Emmanuel, Papageorgiou, Dimitrios, Soulou, Vasiliki, Asturias, Sabrina, Peña, Lenin, O'Connor, Donal B, Luc, Alberto Realis, Russo, Alfio Alessandro, Ruzzenente, Andrea, Taddei, Antonio, Cona, Camilla, Bottini, Corrado, Pascale, Giovanni, Rotunno, Giuseppe, Solaini, Leonardo, Pascale, Marco Maria, Notarnicola, Margherita, Corbellino, Mario, Sacco, Michele, Ubiali, Paolo, Cautiero, Roberto, Bocchetti, Tommaso, Muzio, Elena, Guglielmo, Vania, Morandi, Eugenio, Mao, Patrizio, de Luca, Emilia, Ali, Farah Mahmoud, Žilinskas, Justas, Strupas, Kestutis, Kondrotas, Paulius, Baltrunas, Robertas, Kutkevicius, Juozas, Ignatavicius, Povilas, Tan, Choy Ling, Siaw, Jia Yng, Yam, Sir Young, Wilson, Ling, Aziz, Mohamed Rezal Abdul, Bondin, John, Zorrilla, Carmina Diaz, Majbar, Anass, Sale, Danjuma, Abdullahi, Lawal, Osagie, Olabisi, Faboya, Omolara, Fatuga, Adedeji, Taiwo, Agboola, Nwabuoku, Emeka, Bliksøen, Marte, Khan, Zain Ali, Coronel, Jazmin, Miranda, Cesar, Vasquez, Idelso, Helguero-Santin, Luis M, Rickard, Jennifer, Adedeji, Adesina, Alqahtani, Saleh, Rath, Max, Van Niekerk, Michael, Koto, Modise Zacharia, Matos-Puig, Roel, Israelsson, Leif, Schuetz, Tobias, Yuksek, Mahmut Arif, Mericliler, Meric, Wolf, Bernhard, Fairfield, Cameron, Yong, Guo Liang, Whitehurst, Katharine, Redgrave, Natalie, Musyoka, Caroluce K, Olivier, James, Lee, Kathryn, Cox, Michael, Farhan-Alanie, Muhamed M H, Callan, Rory, Chibuye, Chali, Ali, Tebian Hassanein Ahmed, Rekhis, Syrine, Rommaneh, Muna, Sam, Zi Hao, Pugliesi, Thays Brunelli, Pardo, Gabriel, and Blanco, Ruth

Published
2018
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40. Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector

Author

Ostertag, Derek, Amundson, Karin K, Espinoza, Fernando Lopez, Martin, Bryan, Buckley, Taylor, da Silva, Ana Paula Galvão, Lin, Amy H, Valenta, David T, Perez, Omar D, Ibañez, Carlos E, Chen, Ching-I, Pettersson, Pär L, Burnett, Ryan, Daublebsky, Veronika, Hlavaty, Juraj, Gunzburg, Walter, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, and Robbins, Joan M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Brain Cancer, Brain Disorders, Biotechnology, Genetics, Rare Diseases, Cancer, Gene Therapy, Neurosciences, Animals, Brain Neoplasms, Combined Modality Therapy, Disease Models, Animal, Female, Flucytosine, Fluorouracil, Genetic Therapy, Genetic Vectors, Glioma, Leukemia Virus, Murine, Mice, Mice, Inbred BALB C, Survival Analysis, Tumor Cells, Cultured, brain cancer, cytosine deaminase, 5-fluorocyosine, gene therapy, glioblastoma multiforme, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Patients with the most common and aggressive form of high-grade glioma, glioblastoma multiforme, have poor prognosis and few treatment options. In 2 immunocompetent mouse brain tumor models (CT26-BALB/c and Tu-2449-B6C3F1), we showed that a nonlytic retroviral replicating vector (Toca 511) stably delivers an optimized cytosine deaminase prodrug activating gene to the tumor lesion and leads to long-term survival after treatment with 5-fluorocytosine (5-FC). Survival benefit is dose dependent for both vector and 5-FC, and as few as 4 cycles of 5-FC dosing after Toca 511 therapy provides significant survival advantage. In the virally permissive CT26-BALB/c model, spread of Toca 511 to other tissues, particularly lymphoid tissues, is detectable by polymerase chain reaction (PCR) over a wide range of levels. In the Tu-2449-B6C3F1 model, Toca 511 PCR signal in nontumor tissues is much lower, spread is not always observed, and when observed, is mainly detected in lymphoid tissues at low levels. The difference in vector genome spread correlates with a more effective antiviral restriction element, APOBEC3, present in the B6C3F1 mice. Despite these differences, neither strain showed signs of treatment-related toxicity. These data support the concept that, in immunocompetent animals, a replicating retroviral vector carrying a prodrug activating gene (Toca 511) can spread through a tumor mass, leading to selective elimination of the tumor after prodrug administration, without local or systemic pathology. This concept is under investigation in an ongoing phase I/II clinical trial of Toca 511 in combination with 5-FC in patients with recurrent high-grade glioma (www.clinicaltrials.gov NCT01156584).

Published
2012

42. Copaiba oil’s bactericidal activity and its effects on health and zootechnical performance for Nile tilapia after oral supplementation

Author

Mello, Nicoli Paganoti, primary, Espinoza, Fernando Carlos Ramos, additional, Claudiano, Gustavo da Silva, additional, Yunis-Aguinaga, Jefferson, additional, Carvalho, Janaina Graça de Oliveira, additional, Silva, Josiane Elizabeth Almeida, additional, de Oliveira, Elaine Cristina Pacheco, additional, and de Moraes, Julieta Rodini Engrácia, additional

Published
2023
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43. Effective Gene Therapy for Hemophilia a: Novel Re-Dosable Non-Viral Formulation That Provides Stable, and Durable FVIII Expression with Improved Tolerability

Author

Truong, Brian, primary, Hajj, Khal, additional, Schwerk, Johannes, additional, Zhang, Dongyang, additional, Tamayo, Johnnatan, additional, Guzelsoy, Gizem, additional, Kubicki, Joseph, additional, Davis, Alicia, additional, Huang, Lijun, additional, Vemuri, Gopi, additional, Johnson, Kevin, additional, Smith, Dan, additional, Bendor, Jordan, additional, Li, Mu, additional, Goolyam, Manjunath, additional, Abernathy, Daniel, additional, Nyshadham, Pranav, additional, Espinoza, Fernando, additional, Burrascano, Michelle, additional, Yen, James, additional, Briseno, Kevin, additional, Tong, Min, additional, Beck, Jen, additional, Lucas, Joseph, additional, Battiprolu, Pavan, additional, Bennett, Michael, additional, Madison, Blair, additional, Warner, Brent, additional, Ostertag, Eric, additional, and Rychak, Joshua, additional

Published
2023
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48. Enfermidades parasitárias e bacterianas na piscicultura brasileira: insights e perspectivas

Author

Cruz, Matheus Gomes da, primary, Jerônimo, Gabriela Tomas, additional, Costa, Domickson Silva, additional, Libanori, Maria Clara Miguel, additional, Riofrio, Liseth Vanessa Perenguez, additional, Farias, Caio Francisco Santana, additional, Lopes, Emilly Monteiro, additional, Ferreira, Natália Locks, additional, Mourino, José Luiz Pedreira, additional, Martins, Maurício Laterça, additional, Paz, Deborah Jacob Freire da, additional, Cunha, Larissa Salgado da, additional, Tavares, Guilherme Campos, additional, Gimbo, Rodrigo Yukihiro, additional, Rosário, Angélica Emanuely Costa do, additional, Henrique, Marythelma Campos, additional, Costa, Érik José Carvalho Da, additional, Barbanti, Angelo Carlo Chaparro, additional, Rossi, Rhayza Evelyn Vieira, additional, Adriano, Ana Carolina Anchieta, additional, Mira, Átila Bezerra De, additional, Oliveira, Sara Preato de, additional, Barbosa, Kelly Cristina de Araújo, additional, Pinheiro, Maria Mirtes de Lima, additional, Pedroti, Vinícius Perez, additional, Santos, Bruna Lucieny Temponi, additional, Dantas Filho, Jerônimo Vieira, additional, Schons, Sandro de Vargas, additional, Gotardi, Douglas Guedes, additional, Paula, Matheus Venancio de, additional, Nascimento, Juliana Sousa Terada, additional, Claudiano, Gustavo da Silva, additional, Marcusso, Paulo Fernandes, additional, Yunis-Aguinaga, Jefferson, additional, Ramos-Espinoza, Fernando Carlos, additional, Castro, Marcello Pardi de, additional, Fujimoto, Rodrigo Yudi, additional, and Moraes, Julieta Rodini Engrácia de, additional

Published
2023
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49. Graphical Representations and the Perception of Motion: Integrating Isomorphism through Kinesthesia into Physics Instruction

Author

Espinoza, Fernando

Abstract

The incorporation of engaging and meaningful learning experiences is essential for the enhancement of critical thinking and the development of scientific literacy. The study engaged several groups of students in activities designed to elicit their understanding of a graphical representation of motion, and to determine the kinesthetic effect of using a computer-interfaced motion detector in two isomorphic tasks. (I) A forensic context provided an abstracted determination of their ability to describe the motion of an intruder from the data collected by a sensor, and displayed as a graph; (II) An analysis of the motion of two pendulums, a real and a virtual one (as a simulation). An investigation of students' analysis of graphical representations of motion also emphasized the transferability of similar concepts from hypothetical/virtual scenarios to an experimental task to determine the impact of kinesthesia on performance. The results indicate that the features associated with subjects' own movements, and those of other real objects are statistically and cognitively significant in their improvements on the analysis of graphical representations of motion. The findings have broad implications for the use of inquiry-based and technology-rich contexts in the teaching of science.

Published
2015

50. Effect of dietary inclusion of mannan oligosaccharides on the efficacy of a novel hydrogen peroxide‐inactivated vaccine against Streptococcus agalactiae in Nile tilapia.

Author

Ramos‐Espinoza, Fernando Carlos, Cueva‐Quiroz, Victor Alexander, Alvarez‐Rubio, Norquis Caled, Paganoti de Mello, Nicoli, and de Moraes, Julieta Rodini Engrácia

Subjects
NILE tilapia, STREPTOCOCCUS agalactiae, VACCINE effectiveness, IMMUNE response in fishes, OLIGOSACCHARIDES, BACTERIAL vaccines
Abstract

Mannan oligosaccharides (MOS) have shown to stimulate immune response in different fish species, but the results may appear contradictory and have not been tested in conjunction with vaccination. We hypothesized that dietary MOS supplementation could enhance efficacy and immune responses after immunization with a novel hydrogen peroxide‐inactivated vaccine. Nile Tilapia, Oreochromis niloticus, fingerlings were distributed into four groups (supplemented or not, vaccinated or not) and were used to determine immune and hematological parameters and somatic indexes. For the bacterial challenge and vaccine efficacy test, fish were assigned to five experimental groups. Twenty‐eight days after the feeding trial and vaccination, the groups were challenged intraperitoneally and monitored for 21 days. The relative percent survival of the groups basal diet‐vaccinated and MOS diet‐vaccinated were 98.1% and 100.0%, respectively. The dietary inclusion of MOS after vaccination for 28 days had no influence on vaccine efficacy, which could be explained because of the high efficacy of the vaccine itself. Therefore, we suggest that the contribution of MOS supplementation to immune responses after vaccination in fish would be greater for vaccines with lower efficacy, or when tested for heterologous challenges or for crossed protection. [ABSTRACT FROM AUTHOR]

Published
2024
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