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2. Therapeutic strategy for advanced stages salivary carcinomas of the tongue: A multicenter REFCOR study

Author

Poissonnet, Valentine, Chabrillac, Emilien, Uro-Coste, Emmanuelle, Woisard, Virginie, Moya-Plana, Antoine, Espitalier, Florent, Castelli, Joel, Dedieu, Thibault, Salas, Sébastien, Garrel, Renaud, Baudouin, Robin, Poissonnet, Gilles, Castain, Claire, Barbut, Jonathan, Mirghani, Haitham, Evrard, Diane, Bouchain, Olivier, Marie, Jean Paul, Orliac, Hélène, Ceruse, Philippe, Dufour, Xavier, Brenet, Esteban, Rambeau, Audrey, Herman, Philippe, Abu Shama, Yazan, Bertolus, Chloé, Atallah, Sarah, Morinière, Sylvain, Righini, Christian, Mouawad, François, Duflo, Suzy, Segier, Bertille, and Vergez, Sébastien

Published
2024
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3. Survival outcomes, prognostic factors, and effect of adjuvant radiotherapy and prophylactic neck dissection in salivary acinic cell carcinoma: A prospective multicenter REFCOR study of 187 patients

Author

Chatelet, Florian, Ferrand, François Régis, Atallah, Sarah, Thariat, Juliette, Mouawad, François, Fakhry, Nicolas, Malard, Olivier, Even, Caroline, de Monès, Erwan, Uro-Coste, Emmanuelle, Benzerdjeb, Nazim, Hans, Stéphane, Testelin, Sylvie, Mauvais, Olivier, Evrard, Diane, Bastit, Vianney, Salas, Sébastien, Espitalier, Florent, Classe, Marion, Digue, Laurence, Doré, Mélanie, Wong, Stéphanie, Dupin, Charles, Nguyen, France, Bettoni, Jeremie, Lapierre, Ariane, Colin, Emilien, Philouze, Pierre, Vergez, Sébastien, Baujat, Bertrand, Herman, Philippe, and Verillaud, Benjamin

Published
2023
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5. A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors

Author

Atallah, Sarah, Casiraghi, Odile, Fakhry, Nicolas, Wassef, Michel, Uro-Coste, Emmanuelle, Espitalier, Florent, Sudaka, Anne, Kaminsky, Marie Christine, Dakpe, Stéphanie, Digue, Laurence, Bouchain, Olivier, Morinière, Sylvain, Hourseau, Muriel, Bertolus, Chloé, Jegoux, Franck, Thariat, Juliette, Calugaru, Valentin, Schultz, Philippe, Philouze, Pierre, Mauvais, Olivier, Righini, Christian A., Badoual, Cécile, Saroul, Nicolas, Goujon, Jean Michel, Marie, Jean Paul, Taouachi, Rabah, Brenet, Esteban, Aupérin, Anne, and Baujat, Bertrand

Published
2020
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7. Oncological and functional outcomes for transoral robotic surgery following previous radiation treatment for upper aerodigestive tract head and neck cancers. A French multicenter GETTEC group study

Author

Malard, Olivier, primary, Karakachoff, Matilde, additional, Ferron, Christophe, additional, Hans, Stéphane, additional, Vergez, Sébastien, additional, Garrel, Renaud, additional, Gorphe, Philippe, additional, Ramin, Lionel, additional, Santini, Laure, additional, Villeneuve, Alexandre, additional, Lasne‐Cardon, Audrey, additional, Espitalier, Florent, additional, and Hounkpatin, Audrey, additional

Published
2024
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10. Does intraoperative neuromonitoring of recurrent nerves have an impact on the postoperative palsy rate? Results of a prospective multicenter study

Author

Mirallié, Éric, Caillard, Cécile, Pattou, François, Brunaud, Laurent, Hamy, Antoine, Dahan, Marcel, Prades, Michel, Mathonnet, Muriel, Landecy, Gérard, Dernis, Henri-Pierre, Lifante, Jean-Christophe, Sebag, Frederic, Jegoux, Franck, Babin, Emmanuel, Bizon, Alain, Espitalier, Florent, Durand-Zaleski, Isabelle, Volteau, Christelle, and Blanchard, Claire

Published
2018
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12. Treatment strategy in laryngeal chondrosarcoma: a multicenter study of 43 cases

Author

Schleich, Marianne, primary, Laccourreye, Laurent, additional, Marianowski, Remi, additional, Dufour, Xavier, additional, Babin, Emmanuel, additional, Bastit, Vianney, additional, Marie, Jean Paul, additional, Badoual, Cécile, additional, Philouze, Pierre, additional, Espitalier, Florent, additional, Du Bouexic De Pinieux, Gonzague, additional, and Moriniere, Sylvain, additional

Published
2023
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13. Liste des auteurs

Author

Barry, Béatrix, primary, Malard, Olivier, additional, Morinière, Sylvain, additional, Babin, Emmanuel, additional, Badoual, Cécile, additional, Baujat, Bertrand, additional, Bidault, François, additional, de Bonnecaze, Guillaume, additional, Bozec, Alexandre, additional, Céruse, Philippe, additional, Chabrillac, Émilien, additional, Chevalier, Dominique, additional, Choussy, Olivier, additional, Colombe, Cindy, additional, Debry, Christian, additional, Deneuve, Sophie, additional, Dubrulle, Frédérique, additional, Dupret-Bories, Agnès, additional, Espitalier, Florent, additional, Fakhry, Nicolas, additional, Fath, Léa, additional, Gavid, Marie, additional, Guerlain, Joanne, additional, Guiquerro, Sophie, additional, Heutte, Natacha, additional, Janot, François, additional, Jégoux, Franck, additional, Saint-Guily, Jean Lacau, additional, Laccourreye, Ollivier, additional, Lasne-Cardon, Audrey, additional, Lépine, Charles, additional, Lombard, Marine, additional, Mouawad, François, additional, Philouze, Pierre, additional, Pointreau, Yoann, additional, Prades, Jean Michel, additional, de Raucourt, Dominique, additional, Righini, Christian Adrien, additional, Rolland, Frédéric, additional, Santini, Laure, additional, Schultz, Philippe, additional, Tessier, Christophe, additional, Thariat, Juliette, additional, Vergez, Sébastien, additional, Werner, Alfred, additional, and Woisard, Virginie, additional

Published
2019
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14. CICAFAST: comparison of a biological dressing composed of fetal fibroblasts and keratinocytes on a split-thickness skin graft donor site versus a traditional dressing: a randomized controlled trial

Author

Poinas, Alexandra, Perrot, Pierre, Lorant, Judith, Nerrière, Olivier, Nguyen, Jean-Michel, Saiagh, Soraya, Frenard, Cécile, Leduc, Audrey, Malard, Olivier, Espitalier, Florent, Duteille, Franck, Chiffoleau, Anne, Vrignaud, Florence, Khammari, Amir, and Dréno, Brigitte

Published
2019
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17. Les auteurs

Author

Couloigner, Vincent, primary, Fayoux, Pierre, additional, Makeieff, Marc, additional, Nicollas, Richard, additional, Righini, Christian Adrien, additional, Abgral, Ronan, additional, Akkari, Mohamed, additional, Ayari, Sonia, additional, Baujat, Bertrand, additional, Benoudiba, Farida, additional, Bensimon, Jean-Loup, additional, Bernard, Sophie, additional, Bisdorff-Bresson, Annouk, additional, Blanchard, Pierre, additional, Borzic, Michel, additional, Boyer, Julie, additional, Bozec, Alexandre, additional, Brenet, Estéban, additional, Breuskin, Ingrid, additional, Calmels, Marie-Noëlle, additional, Chalard, François, additional, Chopinet, Caroline, additional, Cortese, Sophie, additional, Costes-Martineau, Valérie, additional, De Bonnecaze, Guillaume, additional, Debry, Christian, additional, Valle, Valeria Della, additional, de Monès del Pujol, Erwan, additional, Dufour, Xavier, additional, Espitalier, Florent, additional, Fakhry, Nicolas, additional, Gallois, Yohan, additional, Garcia, Gabriel, additional, Garel, Catherine, additional, Garrel, Renaud, additional, Gorostis, Sophie, additional, Gorphe, Philippe, additional, Guerlain, Joanne, additional, Hartl, Dana M., additional, Jegoux, Franck, additional, Labrousse, Marc, additional, Larralde, Antoine, additional, Leboulanger, Nicolas, additional, Lerat, Justine, additional, Morinière, Sylvain, additional, Mouawad, François, additional, Périé, Sophie, additional, Pondaven-Letourmy, Soizick, additional, Prades, Jean-Michel, additional, Rousset, Jean, additional, Russ, Gilles, additional, Rysman, Bénédicte, additional, Sagardoy, Thomas, additional, Santini, Laure, additional, Tassart, Marc, additional, Teissier, Natacha, additional, Vergez, Sébastien, additional, and Zerdoud, Slimane, additional

Published
2018
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26. Ludwig’s angina: A diagnostic and surgical priority

Author

Vallée, Maxime, primary, Gaborit, Benjamin, additional, Meyer, Jérémy, additional, Malard, Olivier, additional, Boutoille, David, additional, Raffi, François, additional, Espitalier, Florent, additional, and Asseray, Nathalie, additional

Published
2020
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28. MOESM1 of CICAFAST: comparison of a biological dressing composed of fetal fibroblasts and keratinocytes on a split-thickness skin graft donor site versus a traditional dressing: a randomized controlled trial

Author

Poinas, Alexandra, Perrot, Pierre, Lorant, Judith, Nerrière, Olivier, Jean-Michel Nguyen, Saiagh, Soraya, Frenard, Cécile, Leduc, Audrey, Malard, Olivier, Espitalier, Florent, Duteille, Franck, Chiffoleau, Anne, Vrignaud, Florence, Khammari, Amir, and Dréno, Brigitte

Subjects
Data_FILES
Abstract

Additional file 1. Study schedule.

Published
2019
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29. Impact of total thyroidectomy on quality of life: the prospective ThyrQoL multicenter trial

Author

Borel, Frederic, primary, Mirallie, Eric, additional, Tresallet, Christophe, additional, Hamy, Antoine, additional, Mathonnet, Muriel, additional, Lifante, Jean-Christophe, additional, Brunaud, Laurent, additional, Marret, Olivier, additional, Caillard, Cecile, additional, Espitalier, Florent, additional, Menegaux, Fabrice, additional, Drui, Delphine, additional, Hardouin, Jean-Benoit, additional, and Blanchard, Claire, additional

Published
2019
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30. Oncologic outcomes with transoral robotic surgery for supraglottic squamous cell carcinoma: Results of the French Robotic Surgery Group of GETTEC

Author

Doazan, Marianne, primary, Hans, Stéphane, additional, Morinière, Sylvain, additional, Lallemant, Benjamin, additional, Vergez, Sébastien, additional, Aubry, Karine, additional, De Monès, Erwan, additional, Espitalier, Florent, additional, Jegoux, Franck, additional, Pradat, Pierre, additional, and Céruse, Philippe, additional

Published
2018
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32. International consensus (ICON) on assessment of oropharyngeal dysphagia.

Author

UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Espitalier, Florent, Fanous, Amanda, Aviv, Jonathan, Bassiouny, Samia, Desuter, Gauthier, Nerurkar, Nupur, Postma, Gregory, Crevier-Buchman, Lise, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Espitalier, Florent, Fanous, Amanda, Aviv, Jonathan, Bassiouny, Samia, Desuter, Gauthier, Nerurkar, Nupur, Postma, Gregory, and Crevier-Buchman, Lise

Abstract

OBJECTIVE: To present international recommendations regarding the proper evaluation of oropharyngeal dysphagia (OD), both objectively and subjectively (self-evaluation). METHODS: Following a thorough review of the literature, 5 experts in the field from 4 different continents answered separately a questionnaire regarding the work-up of OD. Individual answers were presented and discussed during the world ENT conference that was held in Paris in June 2017. This article will present the recommendations issued from that meeting. Results: For the initial objective assessment of OD, it is recommended to perform either a functional endoscopic evaluation of swallowing (FEES) or a videofluoroscopic swallowing study (VFSS). FEES is the more popular investigation given its increased ease of use and accessibility. When evaluating for the presence of aspiration during the objective evaluation of OD, it is recommended to perform either a FEES or a VFSS. In this case, FEES is the favored investigation given its likely increased sensitivity. In order to highlight the presence of oropharyngeal food residue following the deglutition process, it is recommended to perform either a FEES or a VFSS; FEES likely being the more sensitive investigation while VFSS allows a better quantification of the amount of pharyngeal residue. Is it also recommended to objectify the quality of the deglutition process by means of a score during the objective evaluation of OD. Finally, it is recommended to utilize a self-evaluation questionnaire during research studies exploring the deglutition process.

Published
2018

33. Bone marrow cell extract promotes the regeneration of irradiated bone

Author

Michel, Guillaume, Bléry, Pauline, Henoux, Michaël, Guicheux, Jérôme, Weiss, Pierre, Brouard, Sophie, Malard, Olivier, Espitalier, Florent, Jehan, Frederic, Service d’ORL et de chirurgie cervico-faciale [CHU Hôtel Dieu, Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire d'ingénierie osteo-articulaire et dentaire (LIOAD), Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Nantes - UFR Odontologie, Université de Nantes (UN), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), and The authors received grants from 'Ligue contre le cancer' foundation. For the whole project, we received 20 000 euros (https://www.ligue-cancer.net/).

Subjects
[SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology
Abstract

International audience; Mandibular osteoradionecrosis is a severe side effect of radiotherapy after the treatment of squamous cell carcinomas of the upper aerodigestive tract. As an alternative to its treatment by micro-anastomosed free-flaps, preclinical tissular engineering studies have been developed. Total bone marrow (TBM) associated with biphasic calcium phosphate (BCP) significantly enhanced bone formation in irradiated bone. One mechanism, explaining how bone marrow cells can help regenerate tissues like this, is the paracrine effect. The bone marrow cell extract (BMCE) makes use of this paracrine mechanism by keeping only the soluble factors such as growth factors and cytokines. It has provided significant results in repairing various tissues, but has not yet been studied in irradiated bone reconstruction. The purpose of this study was to evaluate the effect of BMCE via an intraosseous or intravenous delivery, with a calcium phosphate scaffold, in irradiated bone reconstruction. Twenty rats were irradiated on their hind limbs with a single 80-Gy dose. Three weeks later, surgery was performed to create osseous defects. The intraosseous group (n = 12) studied the effect of BMCE in situ, with six combinations (empty defect, BCP, TBM, BCP-TBM, lysate only, BCP-lysate). After four different combinations of implantation (empty defect, BCP, TBM, BCP-TBM), the intravenous group (n = 8) received four intravenous injections of BMCE for 2 weeks. Five weeks after implantation, samples were explanted for histological and scanning electron microscopy analysis. Lysate immunogenicity was studied with various mixed lymphocyte reactions. Intravenous injections of BMCE led to a significant new bone formation compared to the intraosseous group. The BCP-TBM mixture remained the most effective in the intraosseous group. However, intravenous injections were more effective, with TBM placed in the defect, with or without biomaterials. Histologically, highly cellularized bone marrow was observed in the defects after intravenous injections, and not after an in situ use of the lysate. The mixed lymphocyte reactions did not show any proliferation after 3, 5, or 7 days of lysate incubation with lymphocytes from another species.This study evaluated the role of BMCE in irradiated bone reconstruction. There were significant results arguing in favor of BMCE intravenous injections. This could open new perspectives to irradiated bone reconstruction.

Published
2017
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35. Clinical and economic evaluation of minimally invasive cartilaginous palisade myringoplasty.

Author

Michel, Guillaume, Espitalier, Florent, Boyer, Julie, Malard, Olivier, and Bordure, Phillipe

Subjects
*OUTPATIENT medical care, *AUDIOMETRY, *COST effectiveness, *EAR surgery, *MINIMALLY invasive procedures, *SURGICAL flaps, *MEDICAL care costs, *MEDICAL referrals, *MIDDLE ear, *POSTOPERATIVE period, *RETROSPECTIVE studies, *TYMPANIC membrane perforation
Abstract

Objectives:To test the clinical and audiometric efficacy of a minimally invasive myringoplasty technique, combining cartilaginous palisades while avoiding flap elevation, for small and wide perforations. Methods:Over 4 years, this retrospective study included all patients over 6 years of age presenting an indication for myringoplasty. Several clinical and economic criteria were noted at 7 d, 2 months, 6 months and 2 years postoperative. The main outcome was the absence of perforation 2 years postoperative. The secondary outcomes were an audiometric gain at 6 months and the evaluation of the treatment cost. Results:Thirty patients underwent the minimally invasive technique and 28 patients the technique with an elevation of the tympanomeatal flap. The minimally invasive surgical procedure was shorter (p = .001). At 2 years, the tympanic closure rate was equivalent (95% versus 89.5%,p = .77). The audiometric gain was similar between the two techniques (p = .09). From a medico-economic point of view, the minimally invasive procedure was the most effective because it was three times less expensive than the conventional technique with no reduction in efficacy (p = .02). Conclusion:This quick and easy technique could be developed in an ambulatory setting or even in conditions adapted to consultation. [ABSTRACT FROM PUBLISHER]

Published
2018
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36. Determining a Clinically Relevant Strategy for Bone Tissue Engineering: An “All-in-One” Study in Nude Mice

Author

Corre, Pierre, primary, Merceron, Christophe, additional, Vignes, Caroline, additional, Sourice, Sophie, additional, Masson, Martial, additional, Durand, Nicolas, additional, Espitalier, Florent, additional, Pilet, Paul, additional, Cordonnier, Thomas, additional, Mercier, Jacques, additional, Remy, Séverine, additional, Anegon, Ignacio, additional, Weiss, Pierre, additional, and Guicheux, Jérôme, additional

Published
2013
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41. Collaborateurs

Author

Aboussouan, Marie-Pierre, Albert, Sébastien, Amouzougan, Stanislas-Adamah, Attye, Arnaud, Ayari-Khalfallah, Sonia, Babin, Emmanuel, Barry, Béatrix, Bazin, Arnaud, Bensimon, Jean-Loup, Besson, Gérard, Binczak, Marie, Blanchard, David, Bollet, Marc, Breton, Pierre, Brunaud, Alain, Calmels, Paul, Céruse, Philippe, Chays, André, Commun, Fabienne, Constant, Isabelle, Cosmidis, Alain, Couloigner, Vincent, Couturaud, Christine, Demarquay, Geneviève, Deramoudt, Véronique, Donnet, Anne, Dreyer, Chantal, Dubard, Thierry, Espitalier, Florent, Fayoux, Pierre, Garrel, Renaud, Gaucher, David, Gilain, Laurent, Giovanni, Antoine, Giraud, Pierric, Grandazzi, Guillaume, Guégan-Massardier, Évelyne, Guy, Nathalie, Herman, Philippe, Labrousse, Marc, Lallemant, Benjamin, Lantéri-Minet, Michel, Laurent, Bernard, Le Floch, Anne, Maindet-Dominici, Caroline, Makeieff, Marc, Malard, Olivier, Mareau, Cécile, Marianowski, Rémi, Martin, Christian, Michel, Justin, Mom, Thierry, Mondain, Michel, Morinière, Sylvain, Navez, Marie-Louise, Nicollas, Richard, Ozkul-Wermester, Ozlem, Paganelli, Arnaud, Perrichon, Céline, Peyron, Roland, Pondaven, Soizick, Prades, Jean-Michel, Radat, Françoise, Ricard, Christine, Righini, Christian Adrien, Rupp, Damien, Sakka, Laurent, Salvat, Éric, Schmerber, Sébastien, Schultz, Philippe, Serra, Éric, Testelin, Sylvie, Thomas, Thierry, Treluyer, Jean-Marc, Tronche, Sophie, Valade, Dominique, Verillaud, Benjamin, and Wood, Chantal

Published
2014
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42. Microarchitecture of irradiated bone: comparison with healthy bone

Author

Bléry, Pauline, Amouriq, Yves, Guédon, Jeanpierre, Pilet, Paul, Normand, Nicolas, Durand, Nicolas, Espitalier, Florent, Arlicot, Aurore, Malard, Olivier, and Weiss, Pierre

Abstract

The squamous cell carcinomas of the upper aero-digestive tract represent about ten percent of cancers. External radiation therapy leads to esthetic and functional consequences, and to a decrease of the bone mechanical abilities. For these patients, the oral prosthetic rehabilitation, including possibilities of dental implant placement, is difficult. The effects of radiotherapy on bone microarchitecture parameters are not well known. Thus, the purpose of this study is to assess the effects of external radiation on bone micro architecture in an experimental model of 25 rats using micro CT. 15 rats were irradiated on the hind limbs by a single dose of 20 Grays, and 10 rats were non irradiated. Images of irradiated and healthy bone were compared. Bone microarchitecture parameters (including trabecular thickness, trabecular number, trabecular separation, connectivity density and tissue and bone volume) between irradiated and non-irradiated bones were calculated and compared using a Mann and Whitney test. After 7 and 12 weeks, images of irradiated and healthy bone are different. Differences on the irradiated and the healthy bone populations exhibit a statistical significance. Trabecular number, connectivity density and closed porosity are less important on irradiated bone. Trabecular thickness and separation increase for irradiated bone. These parameters indicate a decrease of irradiated bone properties. Finally, the external irradiation induces changes on the bone micro architecture. This knowledge is of prime importance for better oral prosthetic rehabilitation, including implant placement.

Published
2012
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43. Impact of total thyroidectomy on quality of life at 6 months: the prospective ThyrQoL multicentre trial.

Author

Mirallié E, Borel F, Tresallet C, Hamy A, Mathonnet M, Lifante JC, Brunaud L, Menégaux F, Hardouin JB, Blanchard C, Ansquer C, Mourrain-Langlois E, Delemazure AS, Perrot B, Longhi M, Nominé C, Espitalier F, Drui D, Caillard C, Renaud-Moreau N, Marret O, Mucci S, and Christou N

Subjects
Adult, Female, Humans, Male, Middle Aged, Postoperative Complications, Prospective Studies, Quality of Life, Thyroidectomy adverse effects, Treatment Outcome, Thyroid Diseases surgery, Thyroidectomy statistics & numerical data
Abstract

Objective: This study is to determine the impact of complications after total thyroidectomy on health-related quality of life (HR-QoL) and to identify significant predictive factors of HR-QoL changes. HR-QoL is usually impaired in patients with thyroid diseases compared to the general population. Thyroidectomy is largely performed in the case of benign thyroid benign and can be associated with long-term complications (vocal cord palsy, hypoparathyroidism)., Design: The prospective ThyrQoL multicenter trial (NCT02167529) included 800 patients who underwent total thyroidectomy for benign or malignant non-extensive disease in seven French referral hospitals between 2014 and 2016., Methods: HR-QoL was assessed using the MOS 36-item short form health survey (SF-36) self-questionnaire with a 6-month follow-up., Results: We observed a significant improvement of HR-QoL 6 months after surgery (P < 0.0001). Postoperative complications were associated with a non-significant impairment of HR-QoL. In multivariable analysis, Graves' disease was associated with a significant improvement of HR-QoL (OR = 2.39 [1.49; 3.84]) and thyroid malignant disease with an impairment of HR-QoL (OR = 1.44 [0.99; 2.08]) after thyroidectomy., Conclusion: We observed a significant improvement of HR-QoL 6 months after total thyroid surgery for benign thyroid disease.

Published
2020
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44. Bone marrow cell extract promotes the regeneration of irradiated bone.

Author

Michel G, Blery P, Henoux M, Guicheux J, Weiss P, Dugast E, Brouard S, Malard O, and Espitalier F

Subjects
Animals, Bone Marrow Cells cytology, Bone Marrow Cells metabolism, Bone Regeneration drug effects, Bone Substitutes therapeutic use, Disease Models, Animal, Extremities radiation effects, Extremities surgery, Femur pathology, Gamma Rays, Hydroxyapatites pharmacology, Hydroxyapatites therapeutic use, Injections, Intravenous, Lymphocytes immunology, Lymphocytes metabolism, Male, Microscopy, Electron, Scanning, Rats, Rats, Inbred Lew, Tibia pathology, Bone Marrow Cells chemistry, Bone Regeneration physiology, Bone Substitutes pharmacology, Radiation Injuries therapy
Abstract

Mandibular osteoradionecrosis is a severe side effect of radiotherapy after the treatment of squamous cell carcinomas of the upper aerodigestive tract. As an alternative to its treatment by micro-anastomosed free-flaps, preclinical tissular engineering studies have been developed. Total bone marrow (TBM) associated with biphasic calcium phosphate (BCP) significantly enhanced bone formation in irradiated bone. One mechanism, explaining how bone marrow cells can help regenerate tissues like this, is the paracrine effect. The bone marrow cell extract (BMCE) makes use of this paracrine mechanism by keeping only the soluble factors such as growth factors and cytokines. It has provided significant results in repairing various tissues, but has not yet been studied in irradiated bone reconstruction. The purpose of this study was to evaluate the effect of BMCE via an intraosseous or intravenous delivery, with a calcium phosphate scaffold, in irradiated bone reconstruction. Twenty rats were irradiated on their hind limbs with a single 80-Gy dose. Three weeks later, surgery was performed to create osseous defects. The intraosseous group (n = 12) studied the effect of BMCE in situ, with six combinations (empty defect, BCP, TBM, BCP-TBM, lysate only, BCP-lysate). After four different combinations of implantation (empty defect, BCP, TBM, BCP-TBM), the intravenous group (n = 8) received four intravenous injections of BMCE for 2 weeks. Five weeks after implantation, samples were explanted for histological and scanning electron microscopy analysis. Lysate immunogenicity was studied with various mixed lymphocyte reactions. Intravenous injections of BMCE led to a significant new bone formation compared to the intraosseous group. The BCP-TBM mixture remained the most effective in the intraosseous group. However, intravenous injections were more effective, with TBM placed in the defect, with or without biomaterials. Histologically, highly cellularized bone marrow was observed in the defects after intravenous injections, and not after an in situ use of the lysate. The mixed lymphocyte reactions did not show any proliferation after 3, 5, or 7 days of lysate incubation with lymphocytes from another species. This study evaluated the role of BMCE in irradiated bone reconstruction. There were significant results arguing in favor of BMCE intravenous injections. This could open new perspectives to irradiated bone reconstruction.

Published
2017
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