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21 results on '"Esquer, Hector"'

5. Data from First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer

Author

Abbott, Joshua M., primary, Zhou, Qiong, primary, Esquer, Hector, primary, Pike, Laura, primary, Broneske, Travis P., primary, Rinaldetti, Sébastien, primary, Abraham, Adedoyin D., primary, Ramirez, Dominique A., primary, Lunghofer, Paul J., primary, Pitts, Todd M., primary, Regan, Daniel P., primary, Tan, Aik Choon, primary, Gustafson, Daniel L., primary, Messersmith, Wells A., primary, and LaBarbera, Daniel V., primary

Published
2023
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6. Supplementary Data from First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer

Author

Abbott, Joshua M., primary, Zhou, Qiong, primary, Esquer, Hector, primary, Pike, Laura, primary, Broneske, Travis P., primary, Rinaldetti, Sébastien, primary, Abraham, Adedoyin D., primary, Ramirez, Dominique A., primary, Lunghofer, Paul J., primary, Pitts, Todd M., primary, Regan, Daniel P., primary, Tan, Aik Choon, primary, Gustafson, Daniel L., primary, Messersmith, Wells A., primary, and LaBarbera, Daniel V., primary

Published
2023
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8. Battery deployments solve grid challenges: the Imperial Irrigation District uses a state-of-the-art battery energy storage system to increase grid reliability

Author

Beltran, Chris and Esquer, Hector

Subjects
Imperial Irrigation District (Imperial, California) -- Powers and duties, Energy storage -- Usage, Energy management -- Analysis, Business, Electronics and electrical industries, Engineering and manufacturing industries
Abstract

The Imperial Irrigation District (IID) has launched a 30-MW/20-MWh lithium-ion battery energy storage system (BESS) that increases reliability across the district's grid and puts the utility on the forefront of [...]

Published
2017

10. Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L

Author

Prigaro, Brett J., primary, Esquer, Hector, additional, Zhou, Qiong, additional, Pike, Laura A., additional, Awolade, Paul, additional, Lai, Xin-He, additional, Abraham, Adedoyin D., additional, Abbott, Joshua M., additional, Matter, Brock, additional, Kompella, Uday B., additional, Messersmith, Wells A., additional, Gustafson, Daniel L., additional, and LaBarbera, Daniel V., additional

Published
2022
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11. Supplemental Material, Supplemental_Material_for_Advanced_High-Throughput_Imaging_Applications_of_Clonogenicity_in_Cancer_by_Esquer_et_al. - Advanced High-Content-Screening Applications of Clonogenicity in Cancer

Author

Esquer, Hector, Zhou, Qiong, Adedoyin D. Abraham, and LaBarbera, Daniel V.

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, Supplemental_Material_for_Advanced_High-Throughput_Imaging_Applications_of_Clonogenicity_in_Cancer_by_Esquer_et_al. for Advanced High-Content-Screening Applications of Clonogenicity in Cancer by Hector Esquer, Qiong Zhou, Adedoyin D. Abraham and Daniel V. LaBarbera in SLAS Discovery

Published
2020
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12. First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer

Author

Abbott, Joshua M., primary, Zhou, Qiong, additional, Esquer, Hector, additional, Pike, Laura, additional, Broneske, Travis P., additional, Rinaldetti, Sébastien, additional, Abraham, Adedoyin D., additional, Ramirez, Dominique A., additional, Lunghofer, Paul J., additional, Pitts, Todd M., additional, Regan, Daniel P., additional, Tan, Aik Choon, additional, Gustafson, Daniel L., additional, Messersmith, Wells A., additional, and LaBarbera, Daniel V., additional

Published
2020
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13. Drug Design Targeting T-Cell Factor-Driven Epithelial–Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer

Author

Abraham, Adedoyin D., primary, Esquer, Hector, additional, Zhou, Qiong, additional, Tomlinson, Nicholas, additional, Hamill, Brayden D., additional, Abbott, Joshua M., additional, Li, Linfeng, additional, Pike, Laura A., additional, Rinaldetti, Sébastien, additional, Ramirez, Dominique A., additional, Lunghofer, Paul J., additional, Gomez, Jose D., additional, Schaack, Jerome, additional, Nemkov, Travis, additional, D’Alessandro, Angelo, additional, Hansen, Kirk C., additional, Gustafson, Daniel L., additional, Messersmith, Wells A., additional, and LaBarbera, Daniel V., additional

Published
2019
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16. Multi-Generational Effect of Western Diet on Colorectal Cancer and Impact of Green Tea on Cancer Prevention

Author

Phatak, Sumira, Neal, Canyon, Contreras, Kevin, Armbrust, Tess, Rodriguez, Daphne, Abercrombie, Braden, Pontsler, Katie, Larson, Deanna, Hunter, Ashli, Esquer, Hector, Cuthbert, Jocelyn, Lefevre, Michael, Hintze, Korry, Ward, Robert, and Benninghoff, Abby

Subjects
Animal Sciences, Nutrition
Abstract

Diet is widely recognized as an important factor in lifetime cancer risk, yet Americans routinely consume foods that are energy-dense and nutrient-poor. Animal model studies to identify functional foods for cancer prevention generally do not account for typical Western dietary patterns with respect to macro- and micronutrient content. The primary objectives of this study were to determine the impact of ancestral and multi-generational consumption of a Western-style diet in a murine model of inflammation-associated colorectal carcinogenesis. Additionally, we sought to determine the efficacy of green tea for prevention of Western diet-enhanced colon tumorigenesis. Previously, our group developed the Total Western Diet (TWD) for rodents, which models the typical American diet with respect to macro- and micronutrient content on an energy density basis, as opposed to other simple high fat diets traditional used in pre-clinical studies. The hypotheses to be tested in this study were 1) that ancestral exposure to the TWD will increase risk of colon cancer in F3 generation offspring and 2) that green tea will have a substantially greater health benefit in mice exposed to a Westernized diet. Mice were bred for three generations, during which they were fed TWD or a simple high fat diet in the F0 only, F0 through F3 or the F3 generation only. The azoxymethane and dextran sodium sulfate model of inflammation-associated CRC was employed in the F3 generation. Other key measures included body weight gain, body composition (fat and lean mass) and glucose tolerance, preliminary data for which will be presented. To date, the animal study has been completed, and analyses of tumorigenesis, histopathology and other disease biomarkers are ongoing.

Published
2016

20. Sense and Release: A Thiol-Responsive Flavonol-Based Photonically Driven Carbon Monoxide-Releasing Molecule That Operates via a Multiple-Input AND Logic Gate.

Author

Soboleva, Tatiana, Esquer, Hector J., Benninghoff, Abby D., and Berreau, Lisa M.

Subjects
*BIOMARKERS, *BIOCHEMISTRY, *CARBON monoxide, *FLAVONOLS, *FLAVONOIDS
Abstract

Molecular structures capable of intracellular information processing that couple responses from biomarker signals to the release of drug molecules represent intelligent delivery systems. Herein we report a chemophotonically driven, sense-of-logic carbon monoxide-releasing molecule (SL-photoCORM). This extended flavonol motif operates via an AND logic gate by first sensing the cellular environment via detection of thiols and then releasing CO when triggered with visible light and O2. Overall, this approach couples the detection of a cellular redox biomarker with the ability to release a small-molecule gasotransmitter known to trigger pathways involved in pro- and anti-inflammatory effects in a dose-dependent manner. Significantly, the fluorescence properties of the flavonol-based SL-photoCORM produce a series of chemophotonic input responses via two photochromatic switches (blue-to-green and green-to-colorless), leading to trackability and spatiotemporal control of CO release. Examination of the O2 requirements of the CO release step revealed that the SL-photoCORM is suitable for use under conditions of variable cellular levels of O2. These combined properties within a single-molecular framework advance the field of CO-releasing molecules by providing feedback on the diversity and complexity of the cellular environment prior to CO release. [ABSTRACT FROM AUTHOR]

Published
2017
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