41,374 results on '"Esser, A."'
Search Results
2. A Probabilistic Model for Self-Supervised Learning
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Fleissner, Maximilian, Esser, Pascal, and Ghoshdastidar, Debarghya
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Computer Science - Machine Learning - Abstract
Self-supervised learning (SSL) aims to find meaningful representations from unlabeled data by encoding semantic similarities through data augmentations. Despite its current popularity, theoretical insights about SSL are still scarce. For example, it is not yet known whether commonly used SSL loss functions can be related to a statistical model, much in the same as OLS, generalized linear models or PCA naturally emerge as maximum likelihood estimates of an underlying generative process. In this short paper, we consider a latent variable statistical model for SSL that exhibits an interesting property: Depending on the informativeness of the data augmentations, the MLE of the model either reduces to PCA, or approaches a simple non-contrastive loss. We analyze the model and also empirically illustrate our findings.
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- 2025
3. Measurement of $\rm ^{6}H$ ground state energy in an electron scattering experiment at MAMI-A1
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Shao, Tianhao, Chen, Jinhui, Pochodzalla, Josef, Achenbach, Patrick, Christmann, Mirco, Distler, Michael O., Doria, Luca, Esser, Anselm, Geratz, Julian, Helmel, Christian, Hoek, Matthias, Kino, Ryoko, Klag, Pascal, Ma, Yu-Gang, Markus, David, Merkel, Harald, Mihovilovič, Miha, Müller, Ulrich, Nagao, Sho, Nakamura, Satoshi N., Nishi, Kotaro, Nishida, Ken, Oura, Fumiya, Pätschke, Jonas, Schlimme, Björn Sören, Sfienti, Concettina, Steger, Daniel, Steinen, Marcell, Thiel, Michaela, Wilczek, Andrzej, and Wilhelm, Luca
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Nuclear Experiment ,Nuclear Theory - Abstract
For the first time the neutron-rich hydrogen isotope $\rm ^{6}H$ was produced in an electron scattering experiment in the reaction $\rm ^{7}Li(e,~e'p\pi^{+})^{6}H$ using the spectrometer facility of the A1 Collaboration at the Mainz Microtron accelerator. By measuring the triple coincidence between the scattered electron, the produced proton, and $\pi^{+}$, the missing mass spectrum of $\rm ^{6}H$ was obtained. A clear peak above $^3$H+n+n+n energy threshold was seen resulting in a ground state energy of $\rm ^{6}H$ at $2.3\pm0.5({\rm stat.})\pm0.4({\rm syst.})$ MeV with a width of $1.9\pm1.0({\rm stat.})\pm0.4({\rm syst.})$ MeV. This work challenges the understandings of multi-nucleon interactions and presents a new method to study light neutron-rich nuclei with electron scattering experiments., Comment: 6 pages, 4 figures
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- 2025
4. Cluster Specific Representation Learning
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Sabanayagam, Mahalakshmi, Al-Dabooni, Omar, and Esser, Pascal
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Computer Science - Machine Learning - Abstract
Representation learning aims to extract meaningful lower-dimensional embeddings from data, known as representations. Despite its widespread application, there is no established definition of a ``good'' representation. Typically, the representation quality is evaluated based on its performance in downstream tasks such as clustering, de-noising, etc. However, this task-specific approach has a limitation where a representation that performs well for one task may not necessarily be effective for another. This highlights the need for a more agnostic formulation, which is the focus of our work. We propose a downstream-agnostic formulation: when inherent clusters exist in the data, the representations should be specific to each cluster. Under this idea, we develop a meta-algorithm that jointly learns cluster-specific representations and cluster assignments. As our approach is easy to integrate with any representation learning framework, we demonstrate its effectiveness in various setups, including Autoencoders, Variational Autoencoders, Contrastive learning models, and Restricted Boltzmann Machines. We qualitatively compare our cluster-specific embeddings to standard embeddings and downstream tasks such as de-noising and clustering. While our method slightly increases runtime and parameters compared to the standard model, the experiments clearly show that it extracts the inherent cluster structures in the data, resulting in improved performance in relevant applications.
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- 2024
5. Regularity of Weighted Tensorized Fractional Brownian Fields and associated function spaces
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Esser, Céline, Loosveldt, Laurent, and Vedel, Béatrice
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Mathematics - Probability ,Mathematics - Functional Analysis - Abstract
We investigate a new class of self-similar fractional Brownian fields, called Weighted Tensorized Fractional Brownian Fields (WTFBS). These fields, introduced in the companion paper \cite{ELLV}, generalize the well-known fractional Brownian sheet (FBs) by relaxing its tensor-product structure, resulting in new self-similar Gaussian fields with stationary rectangular increments that differ from the FBs. We analyze the local regularity properties of these fields and introduce a new concept of regularity through the definition of Weighted Tensorized Besov Spaces. These spaces combine aspects of mixed dominating smoothness spaces and hyperbolic Besov spaces, which are similar in structure to classical Besov spaces. We provide a detailed characterization of these spaces using Littlewood-Paley theory and hyperbolic wavelet analysis.
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- 2024
6. Emergenet: A Digital Twin of Sequence Evolution for Scalable Emergence Risk Assessment of Animal Influenza A Strains
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Wu, Kevin Yuanbo, Li, Jin, Esser-Kahn, Aaron, and Chattopadhyay, Ishanu
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Quantitative Biology - Populations and Evolution ,Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Despite having triggered devastating pandemics in the past, our ability to quantitatively assess the emergence potential of individual strains of animal influenza viruses remains limited. This study introduces Emergenet, a tool to infer a digital twin of sequence evolution to chart how new variants might emerge in the wild. Our predictions based on Emergenets built only using 220,151 Hemagglutinnin (HA) sequences consistently outperform WHO seasonal vaccine recommendations for H1N1/H3N2 subtypes over two decades (average match-improvement: 3.73 AAs, 28.40\%), and are at par with state-of-the-art approaches that use more detailed phenotypic annotations. Finally, our generative models are used to scalably calculate the current odds of emergence of animal strains not yet in human circulation, which strongly correlates with CDC's expert-assessed Influenza Risk Assessment Tool (IRAT) scores (Pearson's $r = 0.721, p = 10^{-4}$). A minimum five orders of magnitude speedup over CDC's assessment (seconds vs months) then enabled us to analyze 6,354 animal strains collected post-2020 to identify 35 strains with high emergence scores ($> 7.7$). The Emergenet framework opens the door to preemptive pandemic mitigation through targeted inoculation of animal hosts before the first human infection., Comment: 35 pages, 15 figures
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- 2024
7. A fluorescent-protein spin qubit
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Feder, Jacob S., Soloway, Benjamin S., Verma, Shreya, Geng, Zhi Z., Wang, Shihao, Kifle, Bethel, Riendeau, Emmeline G., Tsaturyan, Yeghishe, Weiss, Leah R., Xie, Mouzhe, Huang, Jun, Esser-Kahn, Aaron, Gagliardi, Laura, Awschalom, David D., and Maurer, Peter C.
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Quantum Physics ,Physics - Biological Physics ,Physics - Chemical Physics - Abstract
Optically-addressable spin qubits form the foundation of a new generation of emerging nanoscale sensors. The engineering of these sensors has mainly focused on solid-state systems such as the nitrogen-vacancy (NV) center in diamond. However, NVs are restricted in their ability to interface with biomolecules due to their bulky diamond host. Meanwhile, fluorescent proteins have become the gold standard in bioimaging, as they are genetically encodable and easily integrated with biomolecules. While fluorescent proteins have been suggested to possess a metastable triplet state, they have not been investigated as qubit sensors. Here, we realize an optically-addressable spin qubit in the Enhanced Yellow Fluorescent Protein (EYFP) enabled by a novel spin-readout technique. A near-infrared laser pulse allows for triggered readout of the triplet state with up to 44% spin contrast. Using coherent microwave control of the EYFP spin at liquid-nitrogen temperatures, we measure a spin-lattice relaxation time of $(141 \pm 5)\, \mathrm{\mu s}$, a $(16 \pm 2)\, \mathrm{\mu s}$ coherence time under Carr-Purcell-Meiboom-Gill (CPMG) decoupling, and a predicted oscillating (AC) magnetic field sensitivity with an upper bound of $183 \, \mathrm{fT}\, \mathrm{mol}^{1/2}\, \mathrm{Hz}^{-1/2}$. We express the qubit in mammalian cells, maintaining contrast and coherent control despite the complex intracellular environment. Finally, we demonstrate optically-detected magnetic resonance at room temperature in aqueous solution with contrast up to 3%, and measure a static (DC) field sensitivity with an upper bound of $93 \, \mathrm{pT}\, \mathrm{mol}^{1/2}\, \mathrm{Hz}^{-1/2}$. Our results establish fluorescent proteins as a powerful new qubit sensor platform and pave the way for applications in the life sciences that are out of reach for solid-state technologies.
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- 2024
8. Group actions and irrationality in surface families
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Chen, Nathan and Esser, Louis
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Mathematics - Algebraic Geometry ,14E05, 14L30 - Abstract
Rationality specializes in families of surfaces, even with mild singularities. In this paper, we study the analogous question for the degree of irrationality. We prove a specialization result when the degree of irrationality on the generic fiber arises from the quotient by a group action., Comment: 9 pages
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- 2024
9. Three Approaches to the Automation of Laser System Alignment and Their Resource Implications: A Case Study
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Robb, David A., Risbridger, Donald, Mills, Ben, Rakhmatulin, Ildar, Kong, Xianwen, Erden, Mustafa, Esser, M. J. Daniel, Carter, Richard M., and Chantler, Mike J.
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Electrical Engineering and Systems Science - Systems and Control ,Computer Science - Machine Learning ,Computer Science - Robotics - Abstract
The alignment of optical systems is a critical step in their manufacture. Alignment normally requires considerable knowledge and expertise of skilled operators. The automation of such processes has several potential advantages, but requires additional resource and upfront costs. Through a case study of a simple two mirror system we identify and examine three different automation approaches. They are: artificial neural networks; practice-led, which mimics manual alignment practices; and design-led, modelling from first principles. We find that these approaches make use of three different types of knowledge 1) basic system knowledge (of controls, measurements and goals); 2) behavioural skills and expertise, and 3) fundamental system design knowledge. We demonstrate that the different automation approaches vary significantly in human resources, and measurement sampling budgets. This will have implications for practitioners and management considering the automation of such tasks., Comment: Author Accepted Manuscript- 8 pages, The 2024 IEEE 20th International Conference on Automation Science and Engineering (CASE 2024), Aug28-Sep1st 2024, Bari, Italy. Keywords: Automation, optimisation, regression, behaviour analysis, artificial neural networks, optical systems, mathematical model, human factors, sampling cost, cost benefit analysis
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- 2024
10. Faking ZZZ vertices at the LHC
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Cepedello, Ricardo, Esser, Fabian, Hirsch, Martin, and Sanz, Veronica
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High Energy Physics - Phenomenology - Abstract
Searches for anomalous neutral triple gauge boson couplings (NTGCs) provide important tests for the gauge structure of the standard model. At the LHC, NTGCs are searched for via the process $pp \to ZZ \to 4l$, where the two $Z$-bosons are on-shell. In this paper, we discuss how the same process can occur through tree-level diagrams just adding a vector-like quark (VLQ) to the standard model. Since NTGCs are generated in standard model effective theory (SMEFT) only at 1-loop order, vector like quarks could be an important alternative interpretation to, and background for, NTGC searches. Here, we construct a simple example model, discuss low-energy constraints and estimate current and future sensitivities on the model parameters from $pp \to ZZ \to 4l$ searches., Comment: 19 pages, 9 figures
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- 2024
11. Rational weighted projective hypersurfaces
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Esser, Louis
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Mathematics - Algebraic Geometry ,14J70, 14E08, 14M20 - Abstract
A very general hypersurface of dimension $n$ and degree $d$ in complex projective space is rational if $d \leq 2$, but is expected to be irrational for all $n, d \geq 3$. Hypersurfaces in weighted projective space with degree small relative to the weights are likewise rational. In this paper, we introduce rationality constructions for weighted hypersurfaces of higher degree that provide many new rational examples over any field. We answer in the affirmative a question of T. Okada about the existence of very general terminal Fano rational weighted hypersurfaces in all dimensions $n \geq 6$., Comment: 13 pages, 1 figure. v2: final version, to appear in International Mathematics Research Notices
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- 2024
12. Struggles for Recognition in the Pattern of Solidarity
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Esser, Carolina, Aichele, Alexander, Series Editor, Kirste, Stephan, Series Editor, Mahlmann, Matthias, Series Editor, Renzikowski, Joachim, Series Editor, and Esser, Carolina
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- 2025
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13. Struggles for Recognition in the Pattern of Law
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Esser, Carolina, Aichele, Alexander, Series Editor, Kirste, Stephan, Series Editor, Mahlmann, Matthias, Series Editor, Renzikowski, Joachim, Series Editor, and Esser, Carolina
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- 2025
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14. Chinese and Moroccan Struggles for Recognition
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Esser, Carolina, Aichele, Alexander, Series Editor, Kirste, Stephan, Series Editor, Mahlmann, Matthias, Series Editor, Renzikowski, Joachim, Series Editor, and Esser, Carolina
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- 2025
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15. (Mis)recognition of Moroccan Women
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Esser, Carolina, Aichele, Alexander, Series Editor, Kirste, Stephan, Series Editor, Mahlmann, Matthias, Series Editor, Renzikowski, Joachim, Series Editor, and Esser, Carolina
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- 2025
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16. (Mis)recognition of Chinese Women
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Esser, Carolina, Aichele, Alexander, Series Editor, Kirste, Stephan, Series Editor, Mahlmann, Matthias, Series Editor, Renzikowski, Joachim, Series Editor, and Esser, Carolina
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- 2025
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17. From the Hegelian Notion of Recognition to Contemporary Case Studies on the Legal Recognition of Women
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Esser, Carolina, Aichele, Alexander, Series Editor, Kirste, Stephan, Series Editor, Mahlmann, Matthias, Series Editor, Renzikowski, Joachim, Series Editor, and Esser, Carolina
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- 2025
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18. What is Disrespect?
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Esser, Carolina, Aichele, Alexander, Series Editor, Kirste, Stephan, Series Editor, Mahlmann, Matthias, Series Editor, Renzikowski, Joachim, Series Editor, and Esser, Carolina
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- 2025
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19. How to Struggle in the Three Patterns of Recognition?
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Esser, Carolina, Aichele, Alexander, Series Editor, Kirste, Stephan, Series Editor, Mahlmann, Matthias, Series Editor, Renzikowski, Joachim, Series Editor, and Esser, Carolina
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- 2025
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20. What are Struggles for Recognition?
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Esser, Carolina, Aichele, Alexander, Series Editor, Kirste, Stephan, Series Editor, Mahlmann, Matthias, Series Editor, Renzikowski, Joachim, Series Editor, and Esser, Carolina
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- 2025
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21. What is Recognition?
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Esser, Carolina, Aichele, Alexander, Series Editor, Kirste, Stephan, Series Editor, Mahlmann, Matthias, Series Editor, Renzikowski, Joachim, Series Editor, and Esser, Carolina
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- 2025
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22. Improved Three-Dimensional Reconstructions in Electron Ptychography through Defocus Series Measurements
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Schloz, Marcel, Pekin, Thomas C, Brown, Hamish G, Byrne, Dana O, Esser, Bryan D, Terzoudis-Lumsden, Emmanuel, Taniguchi, Takashi, Watanabe, Kenji, Findlay, Scott D, Haas, Benedikt, Ciston, Jim, and Koch, Christoph T
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Biochemistry and Cell Biology ,Engineering ,Materials Engineering ,Biological Sciences ,Bioengineering ,3D reconstruction ,4D-STEM ,depth sectioning ,ptychography ,Condensed Matter Physics ,Microscopy ,Biochemistry and cell biology ,Materials engineering - Abstract
A detailed analysis of ptychography for three-dimensional (3D) phase reconstructions of thick specimens is performed. We introduce multi-focus ptychography, which incorporates a 4D-STEM defocus series to enhance the quality of 3D reconstructions along the beam direction through a higher overdetermination ratio. This method is compared with established multi-slice ptychography techniques, such as conventional ptychography, regularized ptychography, and multi-mode ptychography. Additionally, we contrast multi-focus ptychography with an alternative method that uses virtual optical sectioning through a reconstructed scattering matrix (S-matrix), which offers more precise 3D structure information compared to conventional ptychography. Our findings from multiple 3D reconstructions based on simulated and experimental data demonstrate that multi-focus ptychography surpasses other techniques, particularly in accurately reconstructing the surfaces and interface regions of thick specimens.
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- 2024
23. Text2BIM: Generating Building Models Using a Large Language Model-based Multi-Agent Framework
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Du, Changyu, Esser, Sebastian, Nousias, Stavros, and Borrmann, André
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Computer Science - Artificial Intelligence ,Computer Science - Computation and Language ,Computer Science - Software Engineering - Abstract
The conventional BIM authoring process typically requires designers to master complex and tedious modeling commands in order to materialize their design intentions within BIM authoring tools. This additional cognitive burden complicates the design process and hinders the adoption of BIM and model-based design in the AEC (Architecture, Engineering, and Construction) industry. To facilitate the expression of design intentions more intuitively, we propose Text2BIM, an LLM-based multi-agent framework that can generate 3D building models from natural language instructions. This framework orchestrates multiple LLM agents to collaborate and reason, transforming textual user input into imperative code that invokes the BIM authoring tool's APIs, thereby generating editable BIM models with internal layouts, external envelopes, and semantic information directly in the software. Furthermore, a rule-based model checker is introduced into the agentic workflow, utilizing predefined domain knowledge to guide the LLM agents in resolving issues within the generated models and iteratively improving model quality. Extensive experiments were conducted to compare and analyze the performance of three different LLMs under the proposed framework. The evaluation results demonstrate that our approach can effectively generate high-quality, structurally rational building models that are aligned with the abstract concepts specified by user input. Finally, an interactive software prototype was developed to integrate the framework into the BIM authoring software Vectorworks, showcasing the potential of modeling by chatting.
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- 2024
24. More than 'Left and Right': Revealing Multilevel Online Political Selective Exposure
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Zhang, Yuan, Herrero, Laia Castro, Esser, Frank, and Bovet, Alexandre
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Computer Science - Social and Information Networks - Abstract
Selective exposure, individuals' inclination to seek out information that supports their beliefs while avoiding information that contradicts them, plays an important role in the emergence of polarization. In the political domain, selective exposure is usually measured on a left-right ideology scale, ignoring finer details. Here, we combine survey and Twitter data collected during the 2022 Brazilian Presidential Election and investigate selective exposure patterns between the survey respondents and political influencers. We analyze the followship network between survey respondents and political influencers and find a multilevel community structure that reveals a hierarchical organization more complex than a simple split between left and right. Moreover, depending on the level we consider, we find different associations between network indices of exposure patterns and 189 individual attributes of the survey respondents. For example, at finer levels, the number of influencer communities a survey respondent follows is associated with several factors, such as demographics, news consumption frequency, and incivility perception. In comparison, only their political ideology is a significant factor at coarser levels. Our work demonstrates that measuring selective exposure at a single level, such as left and right, misses important information necessary to capture this phenomenon correctly.
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- 2024
25. Sensorless model-based tension control for a cable-driven exosuit
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Bardi, Elena, Esser, Adrian, Wolf, Peter, Gandolla, Marta, Ambrosini, Emilia, Pedrocchi, Alessandra, and Riener, Robert
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Computer Science - Robotics ,Electrical Engineering and Systems Science - Signal Processing - Abstract
Cable-driven exosuits have the potential to support individuals with motor disabilities across the continuum of care. When supporting a limb with a cable, force sensors are often used to measure tension. However, force sensors add cost, complexity, and distal components. This paper presents a design and control approach to remove the force sensor from an upper limb cable-driven exosuit. A mechanical design for the exosuit was developed to maximize passive transparency. Then, a data-driven friction identification was conducted on a mannequin test bench to design a model-based tension controller. Seventeen healthy participants raised and lowered their right arms to evaluate tension tracking, movement quality, and muscular effort. Questionnaires on discomfort, physical exertion, and fatigue were collected. The proposed strategy allowed tracking the desired assistive torque with an RMSE of 0.71 Nm (18%) at 50% gravity support. During the raising phase, the EMG signals of the anterior deltoid, trapezius, and pectoralis major were reduced on average compared to the no-suit condition by 30%, 38%, and 38%, respectively. The posterior deltoid activity was increased by 32% during lowering. Position tracking was not significantly altered, whereas movement smoothness significantly decreased. This work demonstrates the feasibility and effectiveness of removing the force sensor from a cable-driven exosuit. A significant increase in discomfort in the lower neck and right shoulder indicated that the ergonomics of the suit could be improved. Overall this work paves the way towards simpler and more affordable exosuits., Comment: 19 pages, 10 figures, and 3 tables in the main manuscript. 12 pages, 4 figures, and 13 tables in the supplementary materials
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- 2024
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26. Measurement of the $\mathrm{{}^{12}C}(e,e')$ cross sections at $Q^2=0.8\,\mathrm{GeV}^2/c^2$
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Mihovilovič, M., Doria, L., Achenbach, P., Ankowski, A. M., Bacca, S., Bosnar, D., Denig, A., Distler, M. O., Esser, A., Friščić, I., Giusti, C., Hoek, M., Kegel, S., Littich, M., Megias, G. D., Merkel, H., Muller, U., Pochodzalla, J., Schlimme, B. S., Schoth, M., Sfienti, C., Širca, S., Sobczyk, J. E., Stottinger, Y., and Thiel, M.
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Nuclear Experiment ,Nuclear Theory - Abstract
We present the findings of a study based on a new inelastic electron-scattering experiment on the ${}^{12}\mathrm{C}$ nucleus focusing on the kinematic region of $Q^2=0.8\,\mathrm{GeV}^2/{c}^2$. The measured cross section is sensitive to the transverse response function and provides a stringent test of theoretical models, as well as of the theoretical assumptions made in Monte-Carlo event-generator codes developed for the interpretation of neutrino-nucleus experiments, such as DUNE and HyperK. We find that modern generators such as GENIE and GiBUU reproduce our new experimental data within 10$\%$.
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- 2024
27. Weighted tensorized fractional Brownian textures
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Esser, Céline, Launay, Claire, Loosveldt, Laurent, and Vedel, Béatrice
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Mathematics - Probability - Abstract
This paper presents a new model of textures, obtained as realizations of a new class of fractional Brownian fields. These fields, called weighted tensorized fractional Brownian fields, are obtained by a relaxation of the tensor-product structure that appears in the definition of fractional Brownian sheets. Statistical properties such as self-similarity, stationarity of rectangular increments and regularity properties are obtained. An operator scaling extension is defined and we provide simulations of the fields using their spectral representation.
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- 2024
28. Exceptional Fano varieties with small minimal log discrepancy
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Esser, Louis, Liu, Jihao, and Wang, Chengxi
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Mathematics - Algebraic Geometry ,14J40, 14J45 (primary), 14C20, 14E30, 14J17 (secondary) - Abstract
We construct exceptional Fano varieties with the smallest known minimal log discrepancies in all dimensions. These varieties are well-formed hypersurfaces in weighted projective space. Their minimal log discrepancies decay doubly exponentially with dimension, and achieve the optimal value in dimension 2., Comment: 28 pages
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- 2024
29. Estimating species distribution from camera trap by-catch data, using jaguarundi ( Herpailurus yagouaroundi ) as an example
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Harmsen, Bart J., Williams, Sara, Abarca, Maria, Calderón, Francisco Samuel Álvarez, Araya-Gamboa, Daniela, Avila, Hefer Daniel, Barrantes-Núñez, Mariano, la Cruz, Yaribeth Bravata-de, Broadfield, Joleen, Cabral-Araújo, Valquíria, Calderón, Ana Patricia, Castañeda, Franklin, Corrales-Gutiérrez, Daniel, do Couto-Peret Dias, Bárbara, Marinho, Paulo Henrique Dantas, Devlin, Allison L., Escobar-Anleu, Barbara I., Espinoza-Muñoz, Deiver, Esser, Helen J., Foster, Rebecca J., Fragoso, Carlos Eduardo, Friedeberg, Diana, Herrera, Luis Alberto, Hidalgo-Mihart, Mircea G., Hoogesteijn, Rafael, Jansen, Patrick A., Jędrzejewski, Włodzimierz, la Cruz, Alejandro Jesus-de, de Jesus Rodrigues, Domingos, Jordan, Chris A., Juárez-Lopez, Rugieri, Kadosoe, Vanessa, Kelly, Marcella J., King, Travis W., Lugarini, Camile, Venticinque, Eduardo Martins, da Matta Nigro, Giulia, McPhail, Darby K. T., Meyer, Ninon, Morales-Rivas, Andrea, Nepomuceno, Vance, Nipko, Rob B., Noronha, Janaina, de Oliveira-Vasquez, Mariana, Ouboter, Paul, Paemelaere, Evi A. D., Payán, Esteban, dos Santos, Thais Pereira, Salom-Pérez, Roberto, Sanchez, Emma E., Santos-Simioni, Stephanie, Schmidt, Krzysztof, Stasiukyans, Diana, Tortato, Fernando R., Urbina-Ruiz, Ever, Urquhart, Gerald R., Wong, Wai-Ming, and Robinson, Hugh
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- 2024
30. The impact of experiential avoidance on anxiety and depressive disorders in hematological cancer patients
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Weißflog, Gregor, Ernst, Jochen, Esser, Peter, Platzbecker, Uwe, Vucinic, Vladan, Mehnert-Theuerkauf, Anja, and Springer, Franziska
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- 2025
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31. Does the ChOLE classification relate to the duration of surgery?
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Esser, Julia, Broicher, Leonie, Mayer, Marcel, Eckel, Hans, Jansen, Louis, Nobis, Anne, Faste, Frederik, Klussmann, Jens Peter, and Luers, Jan Christoffer
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- 2025
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32. Disparities in Patient Demographics at a Student-Run Free Clinic: Comparing Clinic Utilization to City, State, and National Trends
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Esser, Katherine, McKeown, Johnny, White, Tatiana, Besly, Steuart, Sim, Julianna, Sparks, Addison, Hatch, Sydney, Paat, Richard, and Matus, Coral
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- 2025
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33. Zum Referentenentwurf des Bundesministeriums für Wohnen, Stadtentwicklung und Bauwesen eines Gesetzes zur Stärkung der integrierten Stadtentwicklung (Stand 29.7.2024) – Bearbeitungsstand: August 2024: Stellungnahme des Deutschen Anwaltvereins vorbereitet durch die Ausschüsse Verwaltungsrecht und Umweltrecht
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Lüttgau, Thomas, Arnold, Jennifer, Dingemann, Kathrin, Esser, Claus, Hellriegel, Mathias, Hilf, Juliane, Hünnekens, Georg, Neusüß, Peter, Rapp, Angela, Müggenborg, Hans-Jürgen, Ackermann, Marie, Beckmann, Martin, Desens, Sabrina, Ewer, Wolfgang, Fellenberg, Frank, Heß, Franziska, Klinger, Remo, Porsch, Winfried, Posser, Herbert, and Schoppen, Claudia
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- 2025
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34. Katheterversorgung: Worauf es im urologischen Alltag ankommt
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Eßer, Melina and Becker, Benedikt
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- 2025
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35. Physician Attitudes Towards Pharmacist-Prescribed HIV Post-Exposure Prophylaxis (PEP): A Survey of a State Medical Association
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Scarnati, Kaylee, Esser, Katherine L., Sim, Julianna M., Vaidya, Varun, Sahloff, Eric, and Duggan, Joan
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- 2024
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36. Schmerzbedingte Stigmatisierung bei Patienten mit Brust‑, Darm‑, Prostata- oder Lungenkrebs: Ergebnisse einer bizentrischen registerbasierten Querschnittstudie
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Roicke, A., Esser, P., Hornemann, B., and Ernst, J.
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- 2024
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37. Relational quantum mechanics, causal composition, and molecular structure
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Esser, Stephen
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- 2024
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38. An Ultra-High Vacuum Scanning Tunneling Microscope with Pulse Tube and Joule-Thomson cooling operating at sub-pm z-noise
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Eßer, Marcus, Pratzer, Marco, Frömming, Marc, Duffhauß, Jonas, Bhaskar, Priyamvada, Krzyzowski, Michael A., and Morgenstern, Markus
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Physics - Instrumentation and Detectors ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science ,Condensed Matter - Other Condensed Matter ,Condensed Matter - Superconductivity - Abstract
We describe a compact ultra-high vacuum (UHV) scanning tunneling microscope (STM) system that does not need any external supply of cooling liquids. It achieves temperatures down to 1.5 K and a z-noise down to 300 fmRMS for the frequency range of 0.1 Hz - 5 kHz (feedback loop off). It employs a pulse tube cryocooler (PTC) and a Joule-Thomson (JT) stage inducing only small temperature oscillations at the STM with amplitude below 1 mK. The challenge to combine an effective vibrational decoupling from the PTC with sufficient thermal conduction is tackled by a multipartite approach. We realize a minimal stiffness of the UHV bellows that connect the PTC and the STM chamber. Fine Copper wires mechanically decouple the PTC stages from cooling plates that carry the thermal shields, the JT stage and the STM. Soft springs decouple the STM from the JT stage. Finally, the STM body has an optimized conical shape and is made of the light and stiff material Shapal Hi MSoft such that a strong reduction of low frequency vibrations results for the tunnel junction. The voltage noise in the tunnel junction is 0.12 mV and an RF antenna close to the tunnel junction provides radio frequency excitations up to 40 GHz with amplitudes up to 10 mV., Comment: 12 pages, 8 figures
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- 2024
39. Hypersurfaces with large automorphism groups
- Author
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Esser, Louis and Li, Jennifer
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Mathematics - Algebraic Geometry ,14J50, 14J70 - Abstract
We find sharp upper bounds on the order of the automorphism group of a hypersurface in complex projective space in every dimension and degree. In each case, we prove that the hypersurface realizing the upper bound is unique up to isomorphism and provide explicit generators for the automorphism group., Comment: 34 pages, 2 tables. v2: final version, to appear in Transactions of the American Mathematical Society
- Published
- 2024
40. Di-Higgs production via Axion-Like Particles
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Esser, Fabian, Madigan, Maeve, Salas-Bernardez, Alexandre, Sanz, Veronica, and Ubiali, Maria
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High Energy Physics - Phenomenology - Abstract
Due to the pseudo-scalar nature of the axion-like particle (ALP), the CP- conserving production of two Higgs bosons via the ALP necessarily involves an additional Z or $\gamma$ boson. We examine the existing constraints from di-Higgs searches at Run 2 of the LHC and find that, despite the presence of extra objects in the final state, these searches are sensitive to a combination of ALP couplings to gluons and three-bosons in the TeV scale range. Additionally, we propose a specialized search strategy incorporating an energetic leptonic Z boson. This refined ALP-induced production process would allow for the identification of the h h $\rightarrow$ 4 b-jet final state and could potentially probe the TeV scale using data from Run 2 of the LHC. This production process can also occur through a coupling between the top quark and the ALP. We translate the current constraints on di-Higgs production into new limits on the ALP-top coupling., Comment: 19 pages, 9 figures
- Published
- 2024
41. The first spectroscopic IR reverberation programme on Mrk 509
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Mitchell, J. A. J., Ward, M. J., Kynoch, D., Santisteban, J. V. Hernández, Horne, K., Pott, J. -U., Esser, J., Mercatoris, P., Packham, C., Ferland, G. J., Lawrence, A., Fischer, T., Barth, A. J., Villforth, C., and Winkler, H.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
Near IR spectroscopic reverberation of Active Galactic Nuclei (AGN) potentially allows the infrared (IR) broad line region (BLR) to be reverberated alongside the disc and dust continua, while the spectra can also reveal details of dust astro-chemistry. Here, we describe results of a short pilot study (17 near-IR spectra over a 183 d period) for Mrk 509. The spectra give a luminosity-weighted dust radius of $\langle R_{\mathrm{d,lum}} \rangle = 186 \pm 4$ light-days for blackbody (large grain dust), consistent with previous (photometric) reverberation campaigns, whereas carbon and silicate dust give much larger radii. We develop a method of calibrating spectral data in objects where the narrow lines are extended beyond the slit width. We demonstrate this by showing our resultant photometric band light curves are consistent with previous results, with a hot dust lag at >40 d in the K band, clearly different from the accretion disc response at <20 d in the z band. We place this limit of 40 d by demonstrating clearly that the modest variability that we do detect in the H and K band does not reverberate on time-scales of less than 40 d. We also extract the Pa$\beta$ line light curve, and find a lag which is consistent with the optical BLR H$\beta$ line of $\sim$70-90 d. This is important as direct imaging of the near-IR BLR is now possible in a few objects, so we need to understand its relation to the better studied optical BLR., Comment: 16 pages, 12 figures
- Published
- 2024
- Full Text
- View/download PDF
42. Accounting for Hysteresis in the Forward Kinematics of Nonlinearly-Routed Tendon-Driven Continuum Robots via a Learned Deep Decoder Network
- Author
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Cho, Brian Y., Esser, Daniel S., Thompson, Jordan, Thach, Bao, Webster III, Robert J., and Kuntz, Alan
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Computer Science - Robotics - Abstract
Tendon-driven continuum robots have been gaining popularity in medical applications due to their ability to curve around complex anatomical structures, potentially reducing the invasiveness of surgery. However, accurate modeling is required to plan and control the movements of these flexible robots. Physics-based models have limitations due to unmodeled effects, leading to mismatches between model prediction and actual robot shape. Recently proposed learning-based methods have been shown to overcome some of these limitations but do not account for hysteresis, a significant source of error for these robots. To overcome these challenges, we propose a novel deep decoder neural network that predicts the complete shape of tendon-driven robots using point clouds as the shape representation, conditioned on prior configurations to account for hysteresis. We evaluate our method on a physical tendon-driven robot and show that our network model accurately predicts the robot's shape, significantly outperforming a state-of-the-art physics-based model and a learning-based model that does not account for hysteresis., Comment: 8 pages, 9 figures, Submitted to IEEE Robotics and Automation Letters
- Published
- 2024
43. Seemingly unrelated Bayesian additive regression trees for cost-effectiveness analyses in healthcare
- Author
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Esser, Jonas, Maia, Mateus, Parnell, Andrew C., Bosmans, Judith, van Dongen, Hanneke, Klausch, Thomas, and Murphy, Keefe
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Statistics - Methodology ,Economics - Econometrics ,Statistics - Applications - Abstract
In recent years, theoretical results and simulation evidence have shown Bayesian additive regression trees to be a highly-effective method for nonparametric regression. Motivated by cost-effectiveness analyses in health economics, where interest lies in jointly modelling the costs of healthcare treatments and the associated health-related quality of life experienced by a patient, we propose a multivariate extension of BART applicable in regression and classification analyses with several correlated outcome variables. Our framework overcomes some key limitations of existing multivariate BART models by allowing each individual response to be associated with different ensembles of trees, while still handling dependencies between the outcomes. In the case of continuous outcomes, our model is essentially a nonparametric version of seemingly unrelated regression. Likewise, our proposal for binary outcomes is a nonparametric generalisation of the multivariate probit model. We give suggestions for easily interpretable prior distributions, which allow specification of both informative and uninformative priors. We provide detailed discussions of MCMC sampling methods to conduct posterior inference. Our methods are implemented in the R package `suBART'. We showcase their performance through extensive simulations and an application to an empirical case study from health economics. By also accommodating propensity scores in a manner befitting a causal analysis, we find substantial evidence for a novel trauma care intervention's cost-effectiveness.
- Published
- 2024
44. System Calibration of a Field Phenotyping Robot with Multiple High-Precision Profile Laser Scanners
- Author
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Esser, Felix, Tombrink, Gereon, Cornelißen, Andre, Klingbeil, Lasse, and Kuhlmann, Heiner
- Subjects
Computer Science - Robotics - Abstract
The creation of precise and high-resolution crop point clouds in agricultural fields has become a key challenge for high-throughput phenotyping applications. This work implements a novel calibration method to calibrate the laser scanning system of an agricultural field robot consisting of two industrial-grade laser scanners used for high-precise 3D crop point cloud creation. The calibration method optimizes the transformation between the scanner origins and the robot pose by minimizing 3D point omnivariances within the point cloud. Moreover, we present a novel factor graph-based pose estimation method that fuses total station prism measurements with IMU and GNSS heading information for high-precise pose determination during calibration. The root-mean-square error of the distances to a georeferenced ground truth point cloud results in 0.8 cm after parameter optimization. Furthermore, our results show the importance of a reference point cloud in the calibration method needed to estimate the vertical translation of the calibration. Challenges arise due to non-static parameters while the robot moves, indicated by systematic deviations to a ground truth terrestrial laser scan.
- Published
- 2024
45. Fast High-Resolution Image Synthesis with Latent Adversarial Diffusion Distillation
- Author
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Sauer, Axel, Boesel, Frederic, Dockhorn, Tim, Blattmann, Andreas, Esser, Patrick, and Rombach, Robin
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Diffusion models are the main driver of progress in image and video synthesis, but suffer from slow inference speed. Distillation methods, like the recently introduced adversarial diffusion distillation (ADD) aim to shift the model from many-shot to single-step inference, albeit at the cost of expensive and difficult optimization due to its reliance on a fixed pretrained DINOv2 discriminator. We introduce Latent Adversarial Diffusion Distillation (LADD), a novel distillation approach overcoming the limitations of ADD. In contrast to pixel-based ADD, LADD utilizes generative features from pretrained latent diffusion models. This approach simplifies training and enhances performance, enabling high-resolution multi-aspect ratio image synthesis. We apply LADD to Stable Diffusion 3 (8B) to obtain SD3-Turbo, a fast model that matches the performance of state-of-the-art text-to-image generators using only four unguided sampling steps. Moreover, we systematically investigate its scaling behavior and demonstrate LADD's effectiveness in various applications such as image editing and inpainting.
- Published
- 2024
46. When can we Approximate Wide Contrastive Models with Neural Tangent Kernels and Principal Component Analysis?
- Author
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Anil, Gautham Govind, Esser, Pascal, and Ghoshdastidar, Debarghya
- Subjects
Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Contrastive learning is a paradigm for learning representations from unlabelled data that has been highly successful for image and text data. Several recent works have examined contrastive losses to claim that contrastive models effectively learn spectral embeddings, while few works show relations between (wide) contrastive models and kernel principal component analysis (PCA). However, it is not known if trained contrastive models indeed correspond to kernel methods or PCA. In this work, we analyze the training dynamics of two-layer contrastive models, with non-linear activation, and answer when these models are close to PCA or kernel methods. It is well known in the supervised setting that neural networks are equivalent to neural tangent kernel (NTK) machines, and that the NTK of infinitely wide networks remains constant during training. We provide the first convergence results of NTK for contrastive losses, and present a nuanced picture: NTK of wide networks remains almost constant for cosine similarity based contrastive losses, but not for losses based on dot product similarity. We further study the training dynamics of contrastive models with orthogonality constraints on output layer, which is implicitly assumed in works relating contrastive learning to spectral embedding. Our deviation bounds suggest that representations learned by contrastive models are close to the principal components of a certain matrix computed from random features. We empirically show that our theoretical results possibly hold beyond two-layer networks.
- Published
- 2024
47. Lattice-commensurate skyrmion texture in a centrosymmetric breathing kagome magnet
- Author
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Hirschberger, Max, Szigeti, Bertalan G., Hemmida, Mamoun, Hirschmann, Moritz M., Esser, Sebastian, Ohsumi, Hiroyuki, Tanaka, Yoshikazu, Spitz, Leonie, Gao, Shang, Kolincio, Kamil K., Sagayama, Hajime, Nakao, Hironori, Yamasaki, Yuichi, Forró, László, von Nidda, Hans-Albrecht Krug, Kézsmárki, István, Arima, Taka-hisa, and Tokura, Yoshinori
- Subjects
Condensed Matter - Strongly Correlated Electrons - Abstract
Skyrmion lattices (SkL) in centrosymmetric materials typically have a magnetic period on the nanometer-scale, so that the coupling between magnetic superstructures and the underlying crystal lattice cannot be neglected. Here, we reveal the commensurate locking of a SkL to the atomic lattice in Gd$_3$Ru$_4$Al$_{12}$ via high-resolution resonant elastic x-ray scattering (REXS). Weak easy-plane magnetic anisotropy, demonstrated here by a combination of ferromagnetic resonance and REXS, penalizes placing a skyrmion core on a site of the atomic lattice. Under these conditions, a commensurate SkL, locked to the crystal lattice, is stable at finite temperatures -- but gives way to a competing incommensurate ground state upon cooling. We discuss the role of Umklapp-terms in the Hamiltonian for the formation of this lattice-locked state, its magnetic space group, the role of slight discommensurations, or (line) defects in the magnetic texture, and contrast our findings with the case of SkLs in noncentrosymmetric material platforms., Comment: 17 pages, 4 figures, additional SI included (19 pages, 11 figures, 1 table)
- Published
- 2024
- Full Text
- View/download PDF
48. Scaling Rectified Flow Transformers for High-Resolution Image Synthesis
- Author
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Esser, Patrick, Kulal, Sumith, Blattmann, Andreas, Entezari, Rahim, Müller, Jonas, Saini, Harry, Levi, Yam, Lorenz, Dominik, Sauer, Axel, Boesel, Frederic, Podell, Dustin, Dockhorn, Tim, English, Zion, Lacey, Kyle, Goodwin, Alex, Marek, Yannik, and Rombach, Robin
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
Diffusion models create data from noise by inverting the forward paths of data towards noise and have emerged as a powerful generative modeling technique for high-dimensional, perceptual data such as images and videos. Rectified flow is a recent generative model formulation that connects data and noise in a straight line. Despite its better theoretical properties and conceptual simplicity, it is not yet decisively established as standard practice. In this work, we improve existing noise sampling techniques for training rectified flow models by biasing them towards perceptually relevant scales. Through a large-scale study, we demonstrate the superior performance of this approach compared to established diffusion formulations for high-resolution text-to-image synthesis. Additionally, we present a novel transformer-based architecture for text-to-image generation that uses separate weights for the two modalities and enables a bidirectional flow of information between image and text tokens, improving text comprehension, typography, and human preference ratings. We demonstrate that this architecture follows predictable scaling trends and correlates lower validation loss to improved text-to-image synthesis as measured by various metrics and human evaluations. Our largest models outperform state-of-the-art models, and we will make our experimental data, code, and model weights publicly available.
- Published
- 2024
49. Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)
- Author
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Schenk, Simon, Sagendorf, Tyler J, Many, Gina M, Lira, Ana K, de Sousa, Luis GO, Bae, Dam, Cicha, Michael, Kramer, Kyle S, Muehlbauer, Michael, Hevener, Andrea L, Rector, R Scott, Thyfault, John P, Williams, John P, Goodyear, Laurie J, Esser, Karyn A, Newgard, Christopher B, Bodine, Sue C, Adkins, Joshua N, Albertson, Brent G, Amar, David, Amper, Mary Anne S, Ashley, Euan, Bamman, Marcas M, Barnes, Jerry, Bergman, Bryan C, Bessesen, Daniel H, Buford, Thomas W, Burant, Charles F, Cutter, Gary R, De Sousa, Luis Gustavo Oliveria, Fernández, Facundo M, Gaul, David A, Ge, Yongchao, Goodpaster, Bret H, Guevara, Kristy, Hirshman, Michael F, Huffman, Kim M, Jackson, Bailey E, Jankowski, Catherine M, Jimenez-Morales, David, Kohrt, Wendy M, Kraus, William E, Lessard, Sarah J, Lester, Bridget, Lindholm, Malene E, Many, Gina, Marjanovic, Nada, Marshall, Andrea G, Melanson, Edward L, Miller, Michael E, Moreau, Kerrie L, Nair, Venugopalan D, Ortlund, Eric A, Qian, Wei-Jun, Rasmussen, Blake B, Richards, Collyn Z-T, Rushing, Scott, Sanford, James A, Schauer, Irene E, Schwartz, Robert S, Sealfon, Stuart C, Seenarine, Nitish, Sparks, Lauren M, Stowe, Cynthia L, Talton, Jennifer W, Teng, Christopher, Tesfa, Nathan D, Thalacker-Mercer, Anna, Trappe, Scott, Trappe, Todd A, Vasoya, Mital, Wheeler, Matthew T, Walkup, Michael P, Yan, Zhen, and Zhen, Jimmy
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Cardiovascular ,Physical Activity ,Behavioral and Social Science ,Animals ,Male ,Rats ,Inbred F344 ,Female ,Physical Conditioning ,Animal ,Adaptation ,Physiological ,Rats ,Aging ,Physical Endurance ,Muscle ,Skeletal ,Endurance Training ,training ,treadmill ,maximal oxygen uptake ,body composition ,citrate synthase ,skeletal muscle ,biorepository ,aging ,MoTrPAC Study Group ,Medical physiology - Abstract
While regular physical activity is a cornerstone of health, wellness, and vitality, the impact of endurance exercise training on molecular signaling within and across tissues remains to be delineated. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to characterize molecular networks underlying the adaptive response to exercise. Here, we describe the endurance exercise training studies undertaken by the Preclinical Animal Sites Studies component of MoTrPAC, in which we sought to develop and implement a standardized endurance exercise protocol in a large cohort of rats. To this end, Adult (6-mo) and Aged (18-mo) female (n = 151) and male (n = 143) Fischer 344 rats were subjected to progressive treadmill training (5 d/wk, ∼70%-75% VO2max) for 1, 2, 4, or 8 wk; sedentary rats were studied as the control group. A total of 18 solid tissues, as well as blood, plasma, and feces, were collected to establish a publicly accessible biorepository and for extensive omics-based analyses by MoTrPAC. Treadmill training was highly effective, with robust improvements in skeletal muscle citrate synthase activity in as little as 1-2 wk and improvements in maximum run speed and maximal oxygen uptake by 4-8 wk. For body mass and composition, notable age- and sex-dependent responses were observed. This work in mature, treadmill-trained rats represents the most comprehensive and publicly accessible tissue biorepository, to date, and provides an unprecedented resource for studying temporal-, sex-, and age-specific responses to endurance exercise training in a preclinical rat model.
- Published
- 2024
50. Higher expression of denervation‐responsive genes is negatively associated with muscle volume and performance traits in the study of muscle, mobility, and aging (SOMMA)
- Author
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Lukasiewicz, Cole J, Tranah, Gregory J, Evans, Daniel S, Coen, Paul M, Barnes, Haley N, Huo, Zhiguang, Esser, Karyn A, Zhang, Xiping, Wolff, Christopher, Wu, Kevin, Lane, Nancy E, Kritchevsky, Steven B, Newman, Anne B, Cummings, Steven R, Cawthon, Peggy M, and Hepple, Russell T
- Subjects
Medical Physiology ,Biomedical and Clinical Sciences ,Aging ,Genetics ,Underpinning research ,1.1 Normal biological development and functioning ,Musculoskeletal ,gene expression profiling ,muscle ,skeletal ,neuromuscular junction ,denervation ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology ,Biological sciences ,Biomedical and clinical sciences - Abstract
With aging skeletal muscle fibers undergo repeating cycles of denervation and reinnervation. In approximately the 8th decade of life reinnervation no longer keeps pace, resulting in the accumulation of persistently denervated muscle fibers that in turn cause an acceleration of muscle dysfunction. The significance of denervation in important clinical outcomes with aging is poorly studied. The Study of Muscle, Mobility, and Aging (SOMMA) is a large cohort study with the primary objective to assess how aging muscle biology impacts clinically important traits. Using transcriptomics data from vastus lateralis muscle biopsies in 575 participants we have selected 49 denervation-responsive genes to provide insights to the burden of denervation in SOMMA, to test the hypothesis that greater expression of denervation-responsive genes negatively associates with SOMMA participant traits that included time to walk 400 meters, fitness (VO2peak), maximal mitochondrial respiration, muscle mass and volume, and leg muscle strength and power. Consistent with our hypothesis, increased transcript levels of: a calciumdependent intercellular adhesion glycoprotein (CDH15), acetylcholine receptor subunits (CHRNA1, CHRND, CHRNE), a glycoprotein promoting reinnervation (NCAM1), a transcription factor regulating aspects of muscle organization (RUNX1), and a sodium channel (SCN5A) were each negatively associated with at least 3 of these traits. VO2peak and maximal respiration had the strongest negative associations with 15 and 19 denervation-responsive genes, respectively. In conclusion, the abundance of denervationresponsive gene transcripts is a significant determinant of muscle and mobility outcomes in aging humans, supporting the imperative to identify new treatment strategies to restore innervation in advanced age.
- Published
- 2024
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