Search

Your search keyword '"Estabrook, Joseph"' showing total 47 results
Start Over Author "Estabrook, Joseph"
47 results on '"Estabrook, Joseph"'

3. An expanded universe of cancer targets

Author

Hahn, William C, Bader, Joel S, Braun, Theodore P, Califano, Andrea, Clemons, Paul A, Druker, Brian J, Ewald, Andrew J, Fu, Haian, Jagu, Subhashini, Kemp, Christopher J, Kim, William, Kuo, Calvin J, McManus, Michael T, B. Mills, Gordon, Mo, Xiulei, Sahni, Nidhi, Schreiber, Stuart L, Talamas, Jessica A, Tamayo, Pablo, Tyner, Jeffrey W, Wagner, Bridget K, Weiss, William A, Gerhard, Daniela S, Dancik, Vlado, Gill, Shubhroz, Hua, Bruce, Sharifnia, Tanaz, Viswanathan, Vasanthi, Zou, Yilong, Dela Cruz, Filemon, Kung, Andrew, Stockwell, Brent, Boehm, Jesse, Dempster, Josh, Manguso, Robert, Vazquez, Francisca, Cooper, Lee AD, Du, Yuhong, Ivanov, Andrey, Lonial, Sagar, Moreno, Carlos S, Niu, Qiankun, Owonikoko, Taofeek, Ramalingam, Suresh, Reyna, Matthew, Zhou, Wei, Grandori, Carla, Shmulevich, Ilya, Swisher, Elizabeth, Cai, Jitong, Chan, Issac S, Dunworth, Matthew, Ge, Yuchen, Georgess, Dan, Grasset, Eloïse M, Henriet, Elodie, Knútsdóttir, Hildur, Lerner, Michael G, Padmanaban, Veena, Perrone, Matthew C, Suhail, Yasir, Tsehay, Yohannes, Warrier, Manisha, Morrow, Quin, Nechiporuk, Tamilla, Long, Nicola, Saultz, Jennifer, Kaempf, Andy, Minnier, Jessica, Tognon, Cristina E, Kurtz, Stephen E, Agarwal, Anupriya, Brown, Jordana, Watanabe-Smith, Kevin, Vu, Tania Q, Jacob, Thomas, Yan, Yunqi, Robinson, Bridget, Lind, Evan F, Kosaka, Yoko, Demir, Emek, Estabrook, Joseph, Grzadkowski, Michael, Nikolova, Olga, Chen, Ken, Deneen, Ben, Liang, Han, Bassik, Michael C, Bhattacharya, Asmita, Brennan, Kevin, Curtis, Christina, Gevaert, Olivier, Ji, Hanlee P, Karlsson, Kasper AJ, Karagyozova, Kremena, Lo, Yuan-Hung, Liu, Katherine, Nakano, Michitaka, Sathe, Anuja, and Smith, Amber R

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Biotechnology, Genetics, Orphan Drug, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Animals, Clinical Trials as Topic, Disease Models, Animal, Drug Delivery Systems, Genomics, Humans, Neoplasms, Tumor Escape, Tumor Microenvironment, Cancer Target Discovery and Development Network, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation.

Published
2021

6. An expanded universe of cancer targets

Author

Dancik, Vlado, Gill, Shubhroz, Hua, Bruce, Sharifnia, Tanaz, Viswanathan, Vasanthi, Zou, Yilong, Dela Cruz, Filemon, Kung, Andrew, Stockwell, Brent, Boehm, Jesse, Dempster, Josh, Manguso, Robert, Vazquez, Francisca, Cooper, Lee A.D., Du, Yuhong, Ivanov, Andrey, Lonial, Sagar, Moreno, Carlos S., Niu, Qiankun, Owonikoko, Taofeek, Ramalingam, Suresh, Reyna, Matthew, Zhou, Wei, Grandori, Carla, Shmulevich, Ilya, Swisher, Elizabeth, Cai, Jitong, Chan, Issac S., Dunworth, Matthew, Ge, Yuchen, Georgess, Dan, Grasset, Eloïse M., Henriet, Elodie, Knútsdóttir, Hildur, Lerner, Michael G., Padmanaban, Veena, Perrone, Matthew C., Suhail, Yasir, Tsehay, Yohannes, Warrier, Manisha, Morrow, Quin, Nechiporuk, Tamilla, Long, Nicola, Saultz, Jennifer, Kaempf, Andy, Minnier, Jessica, Tognon, Cristina E., Kurtz, Stephen E., Agarwal, Anupriya, Brown, Jordana, Watanabe-Smith, Kevin, Vu, Tania Q., Jacob, Thomas, Yan, Yunqi, Robinson, Bridget, Lind, Evan F., Kosaka, Yoko, Demir, Emek, Estabrook, Joseph, Grzadkowski, Michael, Nikolova, Olga, Chen, Ken, Deneen, Ben, Liang, Han, Bassik, Michael C., Bhattacharya, Asmita, Brennan, Kevin, Curtis, Christina, Gevaert, Olivier, Ji, Hanlee P., Karlsson, Kasper A.J., Karagyozova, Kremena, Lo, Yuan-Hung, Liu, Katherine, Nakano, Michitaka, Sathe, Anuja, Smith, Amber R., Spees, Kaitlyn, Wong, Wing Hing, Yuki, Kanako, Hangauer, Matt, Kaufman, Dan S., Balmain, Allan, Bollam, Saumya R., Chen, Wei-Ching, Fan, QiWen, Kersten, Kelly, Krummel, Matthew, Li, Yun Rose, Menard, Marie, Nasholm, Nicole, Schmidt, Christin, Serwas, Nina K., Yoda, Hiroyuki, Ashworth, Alan, Bandyopadhyay, Sourav, Bivona, Trevor, Eades, Gabriel, Oberlin, Stefan, Tay, Neil, Wang, Yuhao, Weissman, Jonathan, Hahn, William C., Bader, Joel S., Braun, Theodore P., Califano, Andrea, Clemons, Paul A., Druker, Brian J., Ewald, Andrew J., Fu, Haian, Jagu, Subhashini, Kemp, Christopher J., Kim, William, Kuo, Calvin J., McManus, Michael T., B. Mills, Gordon, Mo, Xiulei, Sahni, Nidhi, Schreiber, Stuart L., Talamas, Jessica A., Tamayo, Pablo, Tyner, Jeffrey W., Wagner, Bridget K., Weiss, William A., and Gerhard, Daniela S.

Published
2021
Full Text
View/download PDF

7. Supplementary Table 5 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

8. Supplementary Table 4 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

9. Supplementary Table 9 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

10. Supplementary Table 2 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

11. Supplementary Fig. 11 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

12. Supplementary Table 7 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

13. Supplementary Table 11 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

14. Supplementary Fig. 3 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

15. Supplementary Fig. 6 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

16. Data from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

17. Supplementary Fig. 5 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

18. Supplementary Table 6 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

19. Supplementary Fig. 7 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Table 8 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

21. Supplementary Fig. 4 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

22. Supplementary Materials and Methods from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

23. Supplementary Table 3 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

24. Supplementary Fig. 2 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

25. Supplementary Fig. 9 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

26. Supplementary Fig. 8 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
Full Text
View/download PDF

27. Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., additional, Coleman, Daniel J., additional, VanCampen, Jake, additional, Kong, Garth, additional, Macaraeg, Jommel, additional, Estabrook, Joseph, additional, Demir, Emek, additional, Long, Nicola, additional, Bottomly, Daniel, additional, McWeeney, Shannon K., additional, Tyner, Jeffrey W., additional, Druker, Brian J., additional, Maxson, Julia E., additional, and Braun, Theodore P., additional

Published
2023
Full Text
View/download PDF

29. Asxl1 deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors

Author

Braun, Theodore P., primary, Estabrook, Joseph, additional, Schonrock, Zachary, additional, Curtiss, Brittany M., additional, Darmusey, Lucie, additional, Macaraeg, Jommel, additional, Enright, Trevor, additional, Coblentz, Cody, additional, Callahan, Rowan, additional, Yashar, William, additional, Taherinasab, Akram, additional, Mohammed, Hisham, additional, Coleman, Daniel J., additional, Druker, Brian J., additional, Demir, Emek, additional, Lusardi, Theresa A., additional, and Maxson, Julia E., additional

Published
2022
Full Text
View/download PDF

32. An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer

Author

Johnson, Brett E., primary, Creason, Allison L., additional, Stommel, Jayne M., additional, Keck, Jamie M., additional, Parmar, Swapnil, additional, Betts, Courtney B., additional, Blucher, Aurora, additional, Boniface, Christopher, additional, Bucher, Elmar, additional, Burlingame, Erik, additional, Camp, Todd, additional, Chin, Koei, additional, Eng, Jennifer, additional, Estabrook, Joseph, additional, Feiler, Heidi S., additional, Heskett, Michael B., additional, Hu, Zhi, additional, Kolodzie, Annette, additional, Kong, Ben L., additional, Labrie, Marilyne, additional, Lee, Jinho, additional, Leyshock, Patrick, additional, Mitri, Souraya, additional, Patterson, Janice, additional, Riesterer, Jessica L., additional, Sivagnanam, Shamilene, additional, Somers, Julia, additional, Sudar, Damir, additional, Thibault, Guillaume, additional, Weeder, Benjamin R., additional, Zheng, Christina, additional, Nan, Xiaolin, additional, Thompson, Reid F., additional, Heiser, Laura M., additional, Spellman, Paul T., additional, Thomas, George, additional, Demir, Emek, additional, Chang, Young Hwan, additional, Coussens, Lisa M., additional, Guimaraes, Alexander R., additional, Corless, Christopher, additional, Goecks, Jeremy, additional, Bergan, Raymond, additional, Mitri, Zahi, additional, Mills, Gordon B., additional, and Gray, Joe W., additional

Published
2022
Full Text
View/download PDF

33. Disruption of the MYC Super-Enhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., additional, Coleman, Daniel J., additional, Van-Campen, Jake, additional, Kong, Garth, additional, Macaraeg, Jommel, additional, Estabrook, Joseph, additional, Demir, Emek, additional, Long, Nicola, additional, Bottomly, Dan, additional, McWeeney, Shannon K., additional, Tyner, Jeffrey W., additional, Druker, Brian J., additional, Maxson, Julia E., additional, and Braun, Theodore P., additional

Published
2022
Full Text
View/download PDF

34. PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia

Author

Smith, Brittany M., primary, VanCampen, Jake, additional, Kong, Garth L., additional, Yashar, William, additional, Tsang, Yiu H., additional, Horton, Wesley, additional, Coleman, Daniel J., additional, Estabrook, Joseph, additional, Lusardi, Theresa A., additional, Mills, Gordon B., additional, Druker, Brian J., additional, Maxson, Julia E., additional, and Braun, Theodore P., additional

Published
2021
Full Text
View/download PDF

35. 3024 – GERMLINE RUNX1 MUTATIONS -MEDIATED CHANGES COOPERATES WITH INFLAMMATORY MICROENVIRONMENT TO DRIVE DEFECTIVE HEMATOPOIESIS IN FAMILIAL PLATELET DISORDER

Author

Mohammadhosseini, Mona, primary, Duvall, Adam, additional, Chitsazan, Alex, additional, Enright, Trevor, additional, Monteblanco, Andrea, additional, Lin, Hsin-Yun, additional, Ors, Aysegul, additional, Davis, Brett, additional, Estabrook, Joseph, additional, Nikolova, Olga, additional, Craft, Kathleen, additional, Bresciani, Erica, additional, Merguerian, Matthew, additional, Godley, Lucy, additional, Castilla, Lucio, additional, Demir, Emek, additional, Liu, Paul, additional, Mohammed, Hisham, additional, and Agarwal, Anupriya, additional

Published
2021
Full Text
View/download PDF

37. Interplay between Inflammatory Microenvironment and RUNX1-Mediated Transcriptomic Changes Drives Defective Hematopoiesis in Familial Platelet Disorder

Author

M.Hosseini, Mona, Enright, Trevor, Duvall, Adam S, Chitsazan, Alex, Lin, Hsin-Yun, Ors, Aysegul, Davis, Brett, Estabrook, Joseph, Nikolova, Olga, Diemer, Jamie Lynn, Craft, Kathleen, Bresciani, Erica, Calvo, Katherine R., Merguerian, Matthew, Horwitz, Marshall, Keel, Sioban, Godley, Lucy, Castilla, Lucio H., Demir, Emek, Mohammed, Hisham, Liu, Paul Pu, and Agarwal, Anupriya

Published
2023
Full Text
View/download PDF

38. Asxl1deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors

Author

Braun, Theodore P., Estabrook, Joseph, Schonrock, Zachary, Curtiss, Brittany M., Darmusey, Lucie, Macaraeg, Jommel, Enright, Trevor, Coblentz, Cody, Callahan, Rowan, Yashar, William, Taherinasab, Akram, Mohammed, Hisham, Coleman, Daniel J., Druker, Brian J., Demir, Emek, Lusardi, Theresa A., and Maxson, Julia E.

Abstract

Mutations in the gene Additional Sex-Combs Like 1(ASXL1) are recurrent in myeloid malignancies as well as the pre-malignant condition clonal hematopoiesis, where they are universally associated with poor prognosis. However, the role of ASXL1 in myeloid lineage maturation is incompletely described. To define the role of ASXL1 in myelopoiesis, we employed single cell RNA sequencing and a murine model of hematopoietic-specific Asxl1deletion. In granulocyte progenitors, Asxl1deletion leads to hyperactivation of MYC and a quantitative decrease in neutrophil production. This loss of granulocyte production was not accompanied by significant changes in the landscape of covalent histone modifications. However, Asxl1deletion results in a decrease in RNAPII promoter-proximal pausing in granulocyte progenitors, indicative of a global increase in productive transcription. These results suggest that ASXL1 inhibits productive transcription in granulocyte progenitors, identifying a new role for this epigenetic regulator in myeloid development.

Published
2023
Full Text
View/download PDF

39. An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer

Author

Johnson, Brett E., primary, Creason, Allison L., additional, Stommel, Jayne M., additional, Keck, Jamie M., additional, Parmar, Swapnil, additional, Betts, Courtney B., additional, Blucher, Aurora, additional, Boniface, Christopher, additional, Bucher, Elmar, additional, Burlingame, Erik, additional, Camp, Todd, additional, Chin, Koei, additional, Eng, Jennifer, additional, Estabrook, Joseph, additional, Feiler, Heidi S., additional, Hu, Zhi, additional, Kolodzie, Annette, additional, Kong, Ben L., additional, Labrie, Marilyne, additional, Lee, Jinho, additional, Leyshock, Patrick, additional, Mitri, Souraya, additional, Patterson, Janice, additional, Riesterer, Jessica L., additional, Sivagnanam, Shamilene, additional, Somers, Julia, additional, Sudar, Damir, additional, Thibault, Guillaume, additional, Zheng, Christina, additional, Nan, Xiaolin, additional, Heiser, Laura M., additional, Spellman, Paul T., additional, Thomas, George, additional, Demir, Emek, additional, Chang, Young Hwan, additional, Coussens, Lisa M., additional, Guimaraes, Alexander R., additional, Corless, Christopher, additional, Goecks, Jeremy, additional, Bergan, Raymond, additional, Mitri, Zahi, additional, Mills, Gordon B., additional, and Gray, Joe W., additional

Published
2020
Full Text
View/download PDF

40. Oncogenic SETBP1 Mutations Combine with Activating Mutations in CSF3R to Produce a Highly Proliferative, Lethal Leukemia through Aberrant Myc Signaling

Author

Carratt, Sarah A, primary, Braun, Theodore P., additional, Schonrock, Zachary, additional, Smith, Brittany M., additional, Coleman, Daniel J, additional, Kong, Garth, additional, Estabrook, Joseph, additional, Baris, Adrian, additional, Maloney, Lauren, additional, and Maxson, Julia E., additional

Published
2020
Full Text
View/download PDF

41. ASXL1 Directs Neutrophilic Differentiation via Modulation of MYC and RNA Polymerase II

Author

Braun, Theodore P., primary, Estabrook, Joseph, additional, Coleman, Daniel J., additional, Schonrock, Zachary, additional, Smith, Brittany M., additional, Enright, Trevor, additional, Coblentz, Cody, additional, Callahan, Rowan, additional, Mohammed, Hisham, additional, Druker, Brian J., additional, Lusardi, Theresa A., additional, and Maxson, Julia E., additional

Published
2020
Full Text
View/download PDF

42. Transcriptome alterations in myotonic dystrophy skeletal muscle and heart

Author

Wang, Eric T, primary, Treacy, Daniel, additional, Eichinger, Katy, additional, Struck, Adam, additional, Estabrook, Joseph, additional, Olafson, Hailey, additional, Wang, Thomas T, additional, Bhatt, Kirti, additional, Westbrook, Tony, additional, Sedehizadeh, Sam, additional, Ward, Amanda, additional, Day, John, additional, Brook, David, additional, Berglund, J Andrew, additional, Cooper, Thomas, additional, Housman, David, additional, Thornton, Charles, additional, and Burge, Christopher, additional

Published
2018
Full Text
View/download PDF

45. A response to 'The Chaplain's Dilemma'

Author

Estabrook, Joseph W.

Subjects
Philosophy and religion
Abstract

In 'The Chaplain's Dilemma' (11/17), Deacon Tom Cornell articulates well the need for priests in the military, but I disagree with his (and Gordon Zahn's) proposal that the chaplaincy be [...]

Published
2009

46. Abraham the passenger his privilege and duty described in an election-sermon at Boston N.E. May 30. 1705. / By Joseph Easterbrooks [i.e., Esterbrook] A.M. and Pastor of the Church of Christ at Concord. ; [Seven lines of quotations]

Author

Estabrook, Joseph, ca. 1640-1711., Estabrook, Joseph, ca. 1640-1711., Massachusetts. General Court., Estabrook, Joseph, ca. 1640-1711., Estabrook, Joseph, ca. 1640-1711., and Massachusetts. General Court.

Abstract

[2], 22 p. ; 20 cm. (4to), (DLPS) N01008.0001.001, (tcp) N01008, http://quod.lib.umich.edu/t/text/accesspolicy.html, To the extent possible under law, the Text Creation Partnership has waived all copyright and related or neighboring rights to this keyboarded and encoded edition of the work described above, according to the terms of the CC0 1.0 Public Domain Dedication (http://creativecommons.org/publicdomain/zero/1.0/). This waiver does not extend to any page images or other supplementary files associated with this work, which may be protected by copyright or other license restrictions. Please go to http://www.textcreationpartnership.org/ for more information.

Catalog

Books, media, physical & digital resources
See catalog results