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Objectives This study aims to examine age differences in the intensity of chronic pain among middle-aged and older adults, where intensity is measured on a scale differentiating between chronic pain that is often troubling and likely requires intervention versus more endurable sensations. We aim to explore whether individual health and national gross domestic product (GDP) explain these differences as well. Methods Cross-nationally harmonized data from 20 countries on self-reported intensity of chronic pain (0 = no, 1 = mild, 2 = moderate, 3 = severe) in 104,826 individuals aged 50+ observed in 2012–2013. Two-level hierarchical ordinal linear models with individuals nested within countries were used to isolate estimations from heterogeneity explained by methodological differences across single-country studies. Results Overall, mean participant age was 66.9 (SD = 9.9), 56.1% were women, and 41.9% of respondents reported any chronic pain. Chronic pain intensity rose sharply with age in some countries (e.g., Korea and Slovenia), but this association waned or reversed in other countries (e.g., the United States and Denmark). Cross-country variation and age differences in chronic pain were partly explained (85.5% and 35.8%, respectively) by individual-level health (especially arthritis), country-level wealth (as indicated by GDP per capita), and demographics. Discussion Chronic pain intensity is not an inevitable consequence of chronological age, but the consequence of potential selection effects and lower activity levels combined with individual-level health and country-level wealth. Our findings suggest further investigation of health conditions and country affluence settings as potential targets of medical and policy interventions aiming to prevent, reduce, or manage chronic pain among older patients and aging populations.

Background: Acute lymphoblastic leukemia (ALL) is the most common neoplasm of childhood. Survival depends on a series of risk factors (RF) that have not been jointly assessed. This study aimed to identify a joint predictive model for disease-free survival (DFS) and overall survival (OS) in patients with ALL treated with the Total XV chemotherapy protocol. Methods: Retrospective cohort study of 1 to 14 years old children, treated in 2006-2020 for ALL with the Total XV chemotherapy protocol in an Ecuadorian cancer center. Bio demographic, clinical, immunophenotype, translocations (t), response to treatment (RTT), DFS and OS were studied. Analyses included descriptive statistics and predictive structural equations, using global adjustments (X , CFI and RMSEA) and path incorporation/elimination (Lagrange and Wald test). Results: Of the 144 children (54.9% male) studied: 27.8% had infiltration of the Central Nervous System (CNS); 43.1% were low risk; 4.2% presented t(9-22), and 95.8% were immunophenotype B. Negative minimal residual disease (MRD) on days 15 and 42 of the induction phase was 43.8% and 77.1 % respectively. Induction mortality was 9%. DFS and OS was 45% and 75.7% at 111 and 144 months, respectively. Patients with CNS infiltration, high risk and positive MRD on days 15 and 42, had lower DFS and OS (p0.05). Adjustment indicators corroborated the results (CFI 0.91 and RMSEA 0.04). Conclusion: CNS infiltration, high risk, and positive MRD are RF, which jointly explain DFS and OS in patients with ALL treated with the Total XV chemotherapy protocol.

We characterized substance use patterns and co-occurring substance use disorders among active cocaine base paste (CBP) users in Santiago, Chile using data from respondent-driven sampling (RDS) in three areas of Metropolitan Santiago. Recruitment began with nine seeds, reaching 398 active CBP users (18% women; mean age 37.7 years), defined as persons consuming CBP at least twice per week in the last three months. Population proportions and uncertainty were estimated accounting for individuals' social network and homophily. The median CBP age of initiation was 21 years, and the median number of years using CBP was 7 for women and 15 for men. The median days of use in the past month was 25 days, with a median of 56 doses per week. The proportion of monthly income spent on CBP was 65%. The prevalence of substance use disorders (SUDs) were: 98% for CBP, 67% for alcohol, 60% for marijuana, and 41% for cocaine hydrochloride. Heavy polydrug use patterns and co-occurring SUDs are frequent among active CBP users in the metropolitan area of Santiago. Traditional surveillance strategies may have underestimated polysubstance use and co-occurring SUDs in active CBP users. RDS proved to be a feasible methodology that could be effectively used for substance use surveillance among hard-to-reach populations.

Retirement timing can have important health implications. Little is known, however, about older adults’ views on this issue and whether they consider it better to retire later, earlier, on time or anytime. This knowledge gap about older adults’ views is particularly true outside North America and Europe. This qualitative study aims to examine older Chileans’ ideas about the relationship between retirement timing and health and to explore gender and class patterns in qualitative themes identified, knowledge which may strengthen quantitative population-based approaches. Framework analysis was conducted on qualitative accounts from a purposive, non-random sample of 40 older Chileans in six focus groups, stratified by gender and class as marked by lifetime occupation. Transcriptions were coded by two independent reviewers (inter-coder reliability = 81%) according to four deductive categories of retirement timing as well as inductive coding of emergent themes. The content and sequence of codes were visually represented in MAXQDA's document portraits and illustrated with descriptive quotes. Results indicate that participants’ views about when to retire in order to maximise health did not highlight retirement age or timing (later, earlier, on time, anytime). Instead, these older Chileans emphasised that the optimal retirement age depends on other conditions, such as employment quality, retirement income and gender. These views were patterned: lower occupational-class participants emphasised income and job hazards, higher-class males emphasised job satisfaction and higher-class females emphasised gendered patterns. Women and lower-class participants were relatively more favourable to earlier retirements than men and higher-class participants. Overall, qualitative analyses of lay perspectives from understudied country contexts complement and extend population-based models focused on timing or retirement age, suggest specific characteristics of retirement transitions that may moderate health consequences, and highlight class and gender differences in views of retirement timing. More research is needed using mixed-methods approaches and leveraging both purposive and random samples.

Background and aims Uruguay and Chile have the highest levels of marijuana use in Latin America, and have experienced consistent increases during the last two decades. We aim to calculate separate age-period-cohort (APC) effects for past-year marijuana use in Uruguay and Chile, which have similar epidemiologica, and demographic profiles but diverging paths in cannabis regulation. Design APC study in which period and cohort effects were estimated as first derivative deviations from their linear age trend, separately by country and gender. Setting Uruguay and Chile. Participants General population between 15 and 64 years. Measurements Past-year marijuana use from household surveys with five repeated cross-sections between 2001 and 2018 in Uruguay (median n = 4616) and 13 between 1994 and 2018 in Chile (median n = 15 895). Findings Marijuana use prevalence in both countries peaked at 20-24 years of age and increased consistently across calendar years. Period effects were strong and positive, indicating that increases in use were evident across age groups. Relative to 2006 (reference year), Chilean period effects were approximately 48% lower in 1994 and approximately four times higher in 2018; in Uruguay, these effects were approximately 56% lower in 2001 and almost quadrupled in 2018. We observed non-linear cohort effects in Chile and similar patterns in Uruguay for the overall sample and women. In both countries, marijuana use increased for cohorts born between the mid-1970s and early 1990s, even in the context of rising period effects. Prevalence was consistently larger for men, but period increases were stronger in women. Conclusions Age-period-cohort effects on past-year marijuana use appear to have been similar in Chile and Uruguay, decreasing with age and increasing over time at heterogeneous growth rates depending on gender and cohort. Current levels of marijuana use, including age and gender disparities, seem to be associated with recent common historical events in these two countries.

18 pages, 6 figures, 3 tables.-- This is an open access article distributed under the Creative Commons Attribution License, The extract of Cardiospermum halicacabum L. (C. halicacabum) obtained from flower, leaf and vine was loaded into modified phospholipid vesicles aiming at obtaining sprayable, biocompatible and effective nasal spray formulations for the treatment of nasopharyngeal diseases. Penetration enhancer-containing vesicles (PEVs) and hyalurosomes were formulated, and stabilized by adding a commercial gelatin from fish (20 mg/mL) or chondroitin sulfate from catshark cartilages (Scyliorhinus canicula, 20 mg/mL). Cryo-TEM images confirmed the formation of spherical vesicles, while photon correlation spectroscopy analysis disclosed the formation of small and negatively-charged vesicles. PEVs were the smaller vesicles (~100 nm) along with gelatin-hyalurosomes (~120 nm), while chondroitin-PEVs and chondroitin-hyalurosomes were larger (~160 nm). Dispersions prepared with chondroitin sulfate were more homogeneous, as the polydispersity index was ~0.15. The in vitro analysis of the droplet size distribution, average velocity module and spray cone angle suggested a good spray-ability and deposition of formulations in the nasal cavity, as the mean diameter of the droplets was in the range recommended by the Food and Drug Administration for nasal targets. The spray plume analysis confirmed the ability of PEVs, gelatin-PEVs, hyalurosomes and gelatin-hyalurosomes to be atomized in fine droplets homogenously distributed in a full cone plume, with an angle ranging from 25 to 30°. Moreover, vesicles were highly biocompatible and capable of protecting the epithelial cells against oxidative damage, thus preventing the inflammatory state., This work was supported by the PON-RI 2014-2020 research and innovation program, grant number DOT1304004

BACKGROUND Alcohol consumption in later life has increased in the past decade, and the relationship between alcohol consumption and mortality is controversial. Recent studies suggest little, if any, health benefit to alcohol. Yet most rely on single-time point consumption assessments and minimal confounder adjustments. METHODS We report on 16 years of follow-up from the Health and Retirement Study (HRS) cohorts born 1931 to 1941 (N = 7,904, baseline mean age = 61, SD = 3.18). Respondents were queried about drinking frequency/quantity. Mortality was established via exit interviews and confirmed with the national death index. Time-varying confounders included but were not limited to household assets, smoking, body mass index, health/functioning, depression, chronic disease; time-invariant confounders included baseline age, education, sex, and race. RESULTS After adjustment, current abstainers had the highest risk of subsequent mortality, consistent with sick quitters, and moderate (men: HR = 0.74, 95% CI: 0.60 to 0.91; women: HR = 0.82, 95% CI: 0.63 to 1.07) drinking was associated with a lower mortality rate compared with occasional drinking, though smokers and men evidenced less of an inverse association. Quantitative bias analyses indicated that omitted confounders would need to be associated with ~4-fold increases in mortality rates for men and ~9-fold increases for women to change the results. CONCLUSIONS There are consistent associations between moderate/occasional drinking and lower mortality, though residual confounding remains a threat to validity. Continued efforts to conduct large-scale observational studies of alcohol consumption and mortality are needed to characterize the changing patterns of consumption in older age.

Background: Despite its enormous health and social burden, there are limited published studies describing the epidemiology of violent deaths in Chile. We described violent mortality rate trends in Chile between 2001 and 2018, its current spatial distribution and ecological level correlates. Methods: A population-based study using publicly accessible data. We calculated age-adjusted mortality rates per 100,000 persons for sex, age, intention, and mechanism of death. Next, we used linear regression to estimate time trends for sex and intention. We then employed hierarchical Poisson analyses to model the spatial distribution across 345 municipalities and the influence of six ecological level variables. Results: The average rate of violent death in Chile between 2001 and 2018 was 15.9 per 100,000 people, with the majority (70.3%) of these attributed to suicide. Suffocation was the most common mechanism of death for suicide (82.3%) and cut/pierce for homicide (43.1%), followed by firearm (33.2%). Violent deaths are trending downward in Chile across all categories except suicides by women, which have remained stable. Poverty rates and urban population were positively associated with violent mortality rates. Conclusions: Although violence-related deaths seem to be decreasing, disparities across gender, age group, and geographic location may have continuing effects on mortality rates.

Chronic disease and multimorbidity are growing health challenges for aging populations, often coinciding with retirement. We examine late-life predictors of multimorbidity, focusing on the association between retirement sequences and number of chronic diseases. We modeled the number of chronic diseases as a function of six types of previously identified 10-year retirement sequences using Health and Retirement Study (HRS) data for 7,880 Americans observed between ages 60 to 61 and 70 to 71. Our results show that at baseline, the adjusted prevalence of multimorbidity was lowest in sequences characterized by late retirement from full-time work and highest in sequences characterized by early labor-force disengagement. Age increases in multimorbidity varied across retirement sequences, though overall differences in prevalence persisted at age 70 to 71. Earlier life disadvantages did not moderate these associations. Findings suggest further investigation of policies that target health limitations affecting work, promote continued beneficial employment opportunities, and ultimately leverage retirement sequences as a novel path to influence multimorbidity in old age.

8 figures, 3 tables., A total green nanotechnological nasal spray has been manufactured and proposed as an alternative treatment of rhinitis and rhinosinusitis. It was obtained by combining the strengthening effect of liposomes on barrier function, the hydrating and lubricating properties of sodium hyaluronan and the anti-inflammatory and antioxidant activities of the extract of Zingiber officinalis. To this purpose, the extract was loaded in special phospholipid vesicles immobilized with hyaluronic acid (hyalurosomes), which were further enriched with glycerol in the water phase. Liposomes and glycerosomes were prepared as well and used as reference. Vesicles were oligolamellar and multicompartment, as confirmed by cryogenic transmission electron microscopy (cryo-TEM) observation, small in size (~140 nm) and negatively charged (~−23 mV). Spray characteristics were evaluated by using the Spraytec® and instant images, from which the plume angle was measured. The range of the droplet size distribution and the narrow spray angle obtained suggest a good nebulization and a possible local deposition in the nasal cavity. In vitro studies performed by using human keratinocytes confirmed the high biocompatibility of vesicles and their ability to effectively counteract oxidative damage on cells induced by hydrogen peroxide. The overall collected data suggest that our vesicles are suitable as nasal spray.

BACKGROUND AND AIMS: Age-related changes in physiological, metabolic and medication profiles make alcohol consumption likely to be more harmful among older than younger adults. This study aimed to estimate cross-national variation in the quantity and patterns of drinking throughout older age, and to investigate country-level variables explaining cross-national variation in consumption for individuals aged 50 years and older. DESIGN: Cross-sectional observational study using previously harmonized survey data. SETTING: Twenty-two countries surveyed in 2010 or the closest available year. PARTICIPANTS: A total of 106 180 adults aged 50 years and over. MEASUREMENTS: Cross-national variation in age trends were estimated for two outcomes: weekly number of standard drink units (SDUs) and patterns of alcohol consumption (never, ever, occasional, moderate and heavy drinking). Human Development Index and average prices of vodka were used as country-level variables moderating age-related declines in drinking. FINDINGS: Alcohol consumption was negatively associated with age (risk ratio = 0.98; 95% confidence interval = 0.97, 0.99; P-value < 0.001), but there was substantial cross-country variation in the age-related differences in alcohol consumption [likelihood ratio (LR) test P-value < 0.001], even after adjusting for the composition of populations. Countries’ development level and alcohol prices explained 31% of cross-country variability in SDUs (LR test P-value < 0.001) but did not explain cross-country variability in the prevalence of heavy drinkers. CONCLUSIONS: Use and harmful use of alcohol among older adults appears to vary widely across age and countries. This variation can be partly explained both by the country-specific composition of populations and country-level contextual factors such as development level and alcohol prices.

The literature on socio-economic variations in the association between retirement timing and health is inconclusive and largely limited to the moderating role of occupation. By selecting the sample case of Mexico where a sizeable number of older adults have no or very little formal education, this study allows the moderating role of education to be tested properly. Drawing on panel data for 2,430 individuals age 50 and over from the Mexican Health and Aging Study (MHAS) and combining propensity score matching models with fixed-effects regressions, this article investigates differences in the health effects of retirement timing between older adults with varying years of education. Subjective health is measured using a self-reported assessment of respondents’ overall health and physical health as a reverse count of doctor-diagnosed chronic diseases. The results indicate that early transitions into retirement are associated with worse health outcomes, but education fully compensates for the detrimental association with subjective and physical health, while adjusting for baseline health, demographics and socio-economic characteristics. In conclusion, formal education during childhood and adolescence is associated with a long-term protective effect on health. It attenuates negative health consequences of early retirement transitions. Policies and programmes promoting healthy and active ageing would benefit from considering the influence of formal education in shaping older adults’ health after the transition into retirement.

Background Alcohol consumption causes greater harm in older than younger adults. As the population ages, understanding cross-country and time-varying drinking patterns of older adults is of critical importance. Available evidence relies primarily on ecological data. Methods We harmonized survey data for 179,881 adults age 50+ observed repeatedly between 1998 and 2016 in 21 countries. Next, we estimated historical variation in consumption across countries (overall and stratified by gender and age group 50−64/65+). Results On average, 51.95 % of older adults consumed any alcohol over the observed period. For 13 countries, the proportion of older adults who drink increased (mean annual increase: 0.76 percent points). Heavy drinking (men drinks/day>3 or binge>5, women drinks/day>2 or binge>4) peaked at 23.54 % for England in 2010 and lifetime abstainers at 69.65 % for China in 2011. Across countries and among drinkers, consumption frequency was 2.57 days/week, the number of standard drink units when drinking was 2.57, and the average number of drinks/day over a week was 1.12. Consumption patterns varied substantially across countries and historical time. Overall probability and frequency of consumption were higher in men than women, with the largest gaps observed in 2011 for China, but gender gaps decreased (even reversed) in the young old and varied across country and time. Conclusions Wide variation in older adults’ alcohol consumption across countries and time suggests that broad scale prevention and intervention efforts can be harnessed for potential population-level health benefits. Further variation by gender and age reflect physiological and social factors simultaneously shaping alcohol consumption.

Objective: This study analyzes the dynamic association between retirement sequences and activities of daily living (ADLs) trajectories between ages 60 and 70. Method: Retirement sequences previously established for 7,880 older Americans from the Health and Retirement Study were used in hierarchical linear and propensity score full matching models, analyzing their association with ADL trajectories. Results: Sequences of partial retirement from full- or part-time jobs showed higher baseline and slower decline in ADL than sequences characterized by early labor force disengagement. Discussion: The conventional model in which people completely retire from a full-time job at normative ages and the widely promoted new conventional model of late retirement are both associated with better functioning than early labor force disengagement. But unconventional models, where older adults keep partially engaged with the labor force are also significantly associated with better functioning. These findings call attention to more research on potential avenues to simultaneously promote productive engagement and health later in life.

5 figures, 4 tables., Natural nasal spray formulations were prepared by using Zingiber officinalis (Z. officinalis) extract and citral synergically loaded into specifically designed phospholipid vesicles. Phospholipid vesicles were selected according to their stabilizing effect on the nasal mucosal barrier, and their effectiveness was further potentiated by the co-loading of Z. officinalis extract as antioxidant and anti-inflammatory agent, and citral as antibacterial molecule. Cryo-TEM images confirmed the formation of morphologically homogeneous and small vesicles, sized around 100 nm, negatively charged (−44 mV) and highly biocompatible (viability ≥100%) as detected by using epithelial cells. The analysis of size distribution of sprayed droplets, average velocity module and spray cone angle suggested a good aptitude of the vesicles to be nebulized and their effective deposition in the nasal cavity. Moreover, vesicles were effectively capable of inhibiting some nasal pathogenic bacteria (i.e. Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli) and to protect the epithelial cells against oxidative damage. The formulations are natural and safe, and all of them have shown promising technological and biological properties suggesting their possible application in the nasal cavity for the treatment of congestions and non-allergic rhinitis., The authors thank PON-RI 2014–2020 Research and Innovation Program, grant number DOT1304004, for the support. The authors thank for technical and human support provided by TEM measurements carried out in the SGIker Polymer Characterization (UPV/EHU/ ERDF, EU); the NanoBioCel Group of the University of the Basque Country (UPV/EHU), in Vitoria-Gasteiz (Spain); the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) of Zaragoza (Spain); the Molecular Biology Service Lab of the University of Cagliari.

Objective This study aims to address gaps in health conditions and unmet needs in daily activities between people with dementia (PWD) and without dementia in a developing country and to identify the variables associated with unmet needs among PWD to guide practitioners and policymakers in dealing with an increased burden of dementia. Methods Nationally representative data on 4655 Chileans age 60 and over were used to compare health conditions and unmet needs in daily life activities between individuals with (N = 455, 9.6%) and without dementia. Regression analysis was conducted to identify the variables associated with unmet needs among PWD. Results Overall, PWD had worse health and needed greater assistance in performing daily activities than people without dementia. Among PWD, being male was associated with more unmet needs, in both activities of daily living (ADL) and instrumental ADL. Lower educational level and fewer caregivers were associated with more unmet needs for ADL, while inferior functional ability was associated with more unmet needs for instrumental ADL. Conclusions The results from this study call for action by practitioners and policymakers to foster caregiver training, increase supportive services, and advance care planning for PWD.

Atomization of liquids with high viscosity is always a challenge, especially when small diameter droplets and high liquid flow rates are simultaneously required. In the present research, the performance of a Venturi–vortex twin-fluid swirl nozzle is examined, attending to its capabilities to generate droplets with diameters below 20 µm when atomizing pure glycerin at room temperature. In this nozzle, air is injected tangentially in a central convergent section, and discharges suctioning the liquid fed to a coaxial chamber, here using a gear pump. The resulting spray is visualized and analyzed. Droplet size distributions are measured with a laser diffractometer. As expected, droplet diameter increases with liquid flow rate, and quickly diminishes when air flow rate is increased. Sauter mean diameters (SMD) below 15 µm can be obtained even when atomizing pure glycerin. However, these values are obtained for relatively low glycerin flow rates (∼5 l/h), and with rather wide distributions. For 10 l/h and an air-to-liquid mass flow rate ratio (ALR) of 13.7 more than 26% of the glycerin volume is atomized in droplets smaller than 20 µm. Liquid ligaments are observed near the nozzle exit, but they tend to break up while moving downstream.

The success of private pension systems to provide old-age security is mainly a function of continuous individual pension contributions linked to formal employment. Using a rich longitudinal dataset from Chile and employing sequence analysis, this study examines the pension contribution histories and formal employment pathways of a cohort of individuals who began their working lives simultaneously to the introduction of the Chilean private pension system in the early 1980s, which pioneered private-oriented pension reforms worldwide. Results show that more than half of the individuals from this cohort developed labor-force trajectories inconsistent with continuous pension contributions and formal employment, which particularly affects women and lower educated people. We conclude that policy and decision makers focused on aging topics should be aware of the increasing diversity and precariousness of labor-force trajectories when evaluating the performance and sustainability of both private and public pension regimes.

This work investigates the coalescence of water droplets settled on a water–oil interface in the presence of microparticles and surfactant. The successive stages of the coalescence process, including interstitial film formation, drainage, rupture, and retraction, are analyzed in detail. This leads us to distinguish between contrasted situations depending on the nature of the surfactant and its affinity with the microparticles. Hydrophilic particles have been previously shown to promote coalescence by means of a bridging mechanism. In that case, coalescence is a deterministic process that lasts the time required for the drainage to make the film thickness equal to the size of the particles. However, the present study shows how surfactants can totally change the effect of the particles upon coalescence. When surfactant both stabilizes the water–oil interface and adsorbs onto the particles, the bridging mechanism is inhibited and the coalescence becomes a random process. Since molecular forces between facing film interfaces are not attractive, thermal fluctuations are required to initiate the formation of a hole in the adsorbed surfactant layer. Provided the surfactant concentration in the bulk is large enough to ensure that the interfaces are close to saturation, the coalescence is delayed by a stochastic time interval and the drop coalescence becomes a Poisson process. These results shed a new light on the mechanisms of droplet coalescence in complex industrial applications where surfactant and particles are present, either purposely added or present as uncontrolled contaminants.

Background Previous research has explored the relationship between childhood and adulthood stressful life events (SLEs) and adult salivary telomere length (TL), but no research to date has tested different life-course models in which stress in adulthood may fully, partly, or not mediate the relationship between childhood stress and adult TL. Methods To fill this gap, we elaborate over previous work by Puterman et al. (2016) and other standard models that do not account for the temporal order of stressors in childhood and adulthood, by using structural equation modeling (SEM) for a sample of 5754 Health and Retirement Study (HRS) participants to compare the fit of three nested life-course models—social trajectory, early critical period, and cumulative risk. Results Results indicated that the social trajectory model, in which the association between childhood SLEs and TL in later adulthood is fully mediated by adulthood SLEs, fit the data better than the early critical period (no mediation) and cumulative risk (partial mediation) models. Conclusion In the social trajectory model, childhood SLEs are related to TL in later life only through adulthood SLEs. The direct physiological effect of childhood SLEs on TL in later life would be overestimated if adulthood SLEs are overlooked.

An evaluation was conducted on landscape elements (land use, access roads, slopes, and environmental fragility) and trends in the use of soil during the period 2005-2016 in the area proposed for the Biological Corridor Tibas River (CBRT). From these elements and trends, a methodology for the selection of priority sites (SP) was applied for the restoration of plant cover, and a survey to assess the perception and consent of their respective owners was applied. The CBRT has a distribution almost equitable between urban, agricultural and natural use, with an important concentration of forest cover in its high area. However, in 11 years the CBRT has undergone a process of urbanization, up to three times faster than other urban areas in the region, being the agricultural uses the most vulnerable to change. The implementation of the methodology identified 20 priority sites of management; the above-mentioned survey was applied in 10 of them. The 94% of the owners are willing to the restoration, motivated primarily by the conservation of water, biodiversity and landscape. Se evaluaron elementos paisajísticos (uso de suelo, vías de acceso, pendientes y fragilidad ambiental) y tendencias de uso de suelo durante el periodo 2005-2016 en el área propuesta para el Corredor Biológico Río Tibás (CBRT). A partir de ellos, se aplicó una metodología de selección de sitios prioritarios (SP) para la restauración de cobertura vegetal, y se realizó un diagnóstico social para valorar la percepción y anuencia de sus respectivos propietarios. El CBRT posee una distribución casi equitativa entre el uso urbano, agropecuario y natural, con una concentración importante de cobertura boscosa en su zona alta. No obstante, en 11 años ha experimentado un proceso de urbanización hasta tres veces más acelerado que otras zonas de la región, siendo los usos agropecuarios los más vulnerables al cambio. La aplicación de la metodología delimitó 20 SP de manejo, de los cuales,en 10 se realizó el diagnóstico social. El 94 % de los propietarios están anuentes a la restauración, motivados, principalmente, por la conservación del agua, biodiversidad y paisaje. Universidad Nacional, Costa Rica Escuela de Ciencias Biológicas

Atomization of high viscosity liquids for industrial processes requires the design of more efficient atomizers. In this work, the operation of an air-assisted atomizer, based on a Venturi-vortex system, was examined atomizing liquids with increasing viscosity. In this atomizer prototype, air was injected tangentially in a central convergent chamber and discharged axially suctioning liquid from a coaxial compartment through an annular slit. This atomizer is characterized by the generation of a high velocity swirling airstream and the use of large internal liquid passages. The resulting sprays were experimentally analyzed by means of a phase-Doppler Anemometer. The droplet diameter and two velocity components were measured at different axial stations and radial locations along the spray. Operating with low liquid flow rates, a good atomization quality was achieved generating sprays with a significant fraction of small droplets. Drops with diameters up to 50 μm were considered, which constitute 99% of the total number of measured droplets. Sauter mean diameters below 30 μm were obtained even when pure glycerine was atomized. Air/liquid mass flow rate ratios above 7.5 were handled. The effects of varying the air injection pressure and the conical chamber geometry were also investigated. A drop of the atomizer efficiency was noted when a shorter convergent chamber was used.

This paper presents an experimental study on an acoustically forced particle-laden jet. The acoustic disturbances cause a train of strong periodical vortex due to the selected frequency and its high excitation level. The jet Reynolds number is not small (Re = 11,900) and the particle Stokes number is about one, responding partly to the forcing. The flow was tested using a Phase Doppler Anemometer (PDA). The paper includes measurements of both gas and dispersed phase over the whole forcing cycle. An external post-processing (developed by the authors) carefully corrects the bias inherent to the operation principles of the PDA in all supplied averages (including the phase-averaged values). This post-processing gives also some variables which were defined ad-hoc to characterize the periodic structure of the flow. Such information is never given in the previous literature. This work continues a previous study done by the authors. Measurements detect three axial zones. The strong periodic gas vortices control the flow in the area close to the nozzle exit. They generate highly concentrated clusters of particles as well as tongue-shaped structures of radially ejected particles (or radial streaks). Downstream, the gas vortices vanish and inertia plays a central role in the development of the dispersed phase. The particle clustering ends here. Finally, all periodic motion disappears and flow degenerates into an unforced two-phase jet. Radially, the inertial zone of the particulate phase covers the outermost layers. The influence of the particle size is also discussed. The radial dispersion of particles across certain section is quantified by means of a suitably defined parameter. This dispersion radius was measured at the end of the area disturbed by forcing for both the forced and unforced jet. Thus, the comparison assesses the total effect of forcing on the transversal dispersion. The dispersion of the whole size distribution and of each particle size is quantified. Results show that forcing enhances the dispersion and it is controlled mainly by the periodic streaks while turbulence has a secondary role. The streak shape is accurately computed from the measurements and its extension has been successfully related with the particle's history and it size by means of a suitably defined Stokes number. Finally, this study supplies a set of high quality data useful to validate inherently unsteady numerical models. As stated by other authors, there is a lack of periodic well-characterized experiments for validation purposes which mimic the interaction between the particles and the large scales of turbulence.

Countries across the globe are experiencing declining rates of fertility and marriage, which present a distinct challenge for older adults’ social integration, well-being, and end-of-life care. However, older adults who are “alone” (e.g., no partner, no child) may not be lonely, and end-of-life risks faced by “kinless” older adults likely vary significantly by country context. Using harmonized, cross-national data from 20 countries (United States (HRS), England (ELSA), and European Union (SHARE)), we examine associations between family structure, loneliness, and end-of-life outcomes. Although “kinless” family structures are associated with greater loneliness in the pooled sample, the percent of “kinless” who report no signs of loneliness ranges from 7% (Greece) to 56% (Denmark). Family structure is associated with various end-of-life outcomes, and these associations vary by country—likely reflecting differences in healthcare structure. We discuss distinctions between “being alone,” “being lonely,” and “being without care” in light of cross-national variation.

Alcohol consumption is increasing in many countries, and excessive alcohol consumption is particularly increasing among older adults. Excessive alcohol consumption causes morbidity and mortality, especially among older adults, including an increased risk of depressive episodes. We review the mechanisms through which alcohol consumption may affect depression, and argue that the effects of alcohol consumption on depressive episodes among older adults are understudied. We harmonized data among older adults (≥50 years) on alcohol consumption, depressive episodes, and an array of risk factors across 10 years and 19 countries (N=57,276). Alcohol consumption was categorized as current or long-term abstainer, occasional, moderate and heavy drinking at an average of 2.3 follow-up time points. Depressive episodes were measured through the CES-D or EURO-D. Multi-level Cox proportional frailty models in which the random effect has a multiplicative relationship to hazard were estimated with controls for co-occurring medical conditions, health behaviors, and demographics. Long-term alcohol abstainers had a higher hazard of depressive episodes (HR=1.14, 95% C.I. 1.08-1.21), as did those reporting occasional (HR=1.16, 95% C.I. 1.10-1.21) and heavy drinking (HR=1.22, 95% C.I. 1.13-1.30), compared with moderate drinking. Hazard ratios were attenuated in frailty models; heavy drinking, however, remained robustly associated in a random-effects model with a frailty component (HR=1.16, 95% C.I. 1.11-1.21). Interactions were observed by gender and smoking status: long-term abstainers, women's, and smokers' (HR for interaction, 1.04, 95% C.I. 1.00-1.07) hazards of depressive episodes increased more than what would be expected based on their multiplicative effects, when compared to moderate drinking, non-smoking men. Excessive alcohol consumption among older adults is a concern not only for physical, but also for mental health. Physician efforts to screen older adults for excessive alcohol use is critical for mental health to remain strong in aging populations.

This investigation uses case studies and comparative analysis to review and analyze aging policy in Argentina, Chile, Costa Rica, and Mexico and uncovers similarities and relevant trends in the substance of historical and current aging policy across countries. Initial charity-based approaches to poverty and illness have been gradually replaced by a rights-based approach considering broader notions of well-being, and recent reforms emphasize the need for national, intersectoral, evidence-based policy. The results of this study have implications for understanding aging policy in Latin America from a welfare regime and policy makers' perspective, identifying priorities for intervention and informing policy reforms in developing countries worldwide.

In spite of the high prevalence of mental health disorders in Chile, there is a significant financing deficit in this area when compared to the world's average. The financing for mental health has not increased in accordance with the objectives proposed in the 2000 Chilean National Mental Health and Psychiatry Plan, and only three of the six mental health priorities proposed by this plan have secure financial coverage. The National Health Strategy for the Fulfilment of Health Objectives for the decade 2011-2020 acknowledges that mental disorders worsen the quality of life, increase the risk of physical illness, and have a substantial economic cost for the country. Thus, this article focuses on the importance of investing in mental health, the cost of not doing so, and the need for local mental health research. The article discusses how the United States is trying to eliminate the financial discrimination suffered by patients with mental health disorders, and concludes with public policy recommendations for Chile.

Background: Traditional factors leave substantial risk for incident cardiovascular disease (CVD) unexplained. Recent literature addressing this limitation identifies non-traditional risk factors, such as depression and clinical biomarkers. This study explored retirement sequences as a new non-traditional risk factor for CVD among older Americans. Methods: Heart disease and stroke incidence were measured for 7,880 Health and Retirement Study participants age 70 and over. Non-parametric survival curves and time-discrete survival models were used to compare the succeeding incidence of CVD across the retirement sequences that individuals followed between ages 60-61 and 70-71. We employed six holistic types of retirement sequences: (i) early for individuals who completely retired at or before age 62; (ii) complete for the conventional normative model of retirement by which people who are working in full-time jobs completely retire at the legally established age; (iii) ambiguous for people out of the labor force who shifted into retirement; (iv) partial for subjects with full-time jobs that claimed partial pension benefits in their early 60s; (v) compact for individuals moving from part-time positions into partial retirement; and (vi) late for individuals with full-time employments until their late 60s. These sequences were measured as longitudinal pathways of labor-force statuses and transitions measured in two-year intervals between the ages 60-61 to 70-71 years. Models were fitted for the whole sample, as well as males and females separately, adjusting for the probability of dying before CVD onset, sociodemographics, traditional risk factors, and clinical characteristics. Results: Out of all participants, 78.1% (6154/7880) reported at least one adverse cardiovascular event after age 70. Individuals following retirement sequences characterized by a progression from full-time jobs to either early retirement (heart disease, HR 3.07 CI95% 2.89-3.26 p Conclusions: Retirement sequences may indeed be regarded as a non-traditional risk factor for CVD in aging populations. Keywords: Retirement-Heart disease-Stroke-Work

[EN] Ultrasonic atomization is very convenient because it can generate droplets with diameters of a few microns and with very narrow size distribution. Besides, opposite to twin fluid nozzles, in ultrasonic atomization, droplet generation and transport are decoupled processes. Droplets are ejected from the liquid surface with very low velocities, so driving them is relatively simple. Although this atomization method is now common in some specific applications, for example in household humidifiers, there are still some details about the physics of this process that are not completely understood. Up to date, most of the published results have been limited to experiments with water. However, it has been demonstrated that atomization rates quickly decrease as liquid viscosity increases. This work analyzes the characteristics of ultrasonic atomization of some alternative fluids to determine if there is any influence of other physical properties such as surface tension or vapor pressure. Experiments are performed using a commercial piezoceramic disk with a resonance frequency of 1.65 MHz. The disk is excited with a sinusoidal signal with voltage amplitudes that go up to 60 V. Sprays are visually characterized analyzing instantaneous images and high speed video sequences. Besides atomization rates are calculated by measuring the weight loss in a fixed time., This work has been partially funded by the Secretariat of State for Research of the Spanish Ministry of Economy and Competitiveness under project DPI2013-45814-P. Support of the Regiona

Purpose of the Study A destandardization of labor-force patterns revolving around retirement has been observed in recent literature. It is unclear, however, to which degree and of which kind. This study looked at sequences rather than individual statuses or transitions and argued that differentiating older Americans’ retirement sequences by type, order, and timing and considering gender, class, and race differences yields a less destandardized picture. Design and Methods Sequence analysis was employed to analyze panel data from the Health and Retirement Study (HRS) for 7,881 individuals observed 6 consecutive times between ages 60–61 and 70–71. Results As expected, types of retirement sequences were identified that cannot be subsumed under the conventional model of complete retirement from full-time employment around age 65. However, these retirement sequences were not entirely destandardized, as some irreversibility and age-grading persisted. Further, the degree of destandardization varied along gender, class, and race. Unconventional sequences were archetypal for middle-level educated individuals and Blacks. Also, sequences for women and individuals with lower education showed more unemployment and part-time jobs, and less age-grading. Implications A sequence-analytic approach that models group differences uncovers misjudgments about the degree of destandardization of retirement sequences. When a continuous process is represented as individual transitions, the overall pattern of retirement sequences gets lost and appears destandardized. These patterns get further complicated by differences in social structures by gender, class, and race in ways that seem to reproduce advantages that men, more highly educated individuals, and Whites enjoy in numerous areas over the life course.