1. HIV-associated and idiopathic-acquired haemophilia A: A single-centre case series from Cape Town, South Africa
- Author
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Shein, R., Du Toit, J., Goeijenbier, M., Du Toit, C., and Estelle Ramona Verburgh
- Subjects
Adult ,Aged, 80 and over ,Male ,HIV ,HIV Infections ,Induction Chemotherapy ,Middle Aged ,Hemophilia A ,South Africa ,Humans ,Female ,Partial Thromboplastin Time ,Immunosuppressive Agents ,Autoantibodies - Abstract
Acquired haemophilia A is a rare coagulation disorder, which can lead to life-threatening haemorrhages if not identified and treated promptly. It is characterised by the presence of autoantibodies (inhibitors) to factor VIII. Acquired haemophilia A associated with HIV is a rare but well described phenomenon with limited directions to its management. We comparatively describe four patients - two with HIV and two without - that presented with unusual bleeding episodes with a prolonged activated partial thromboplastin time secondary to factor VIII inhibitors. An empiric observation is that the patients with acquired haemophilia A associated with HIV had higher antibody titres at presentation, that required more prolonged immunosuppressive therapy to induce remission.
- Published
- 2020