583 results on '"Estrada, Vicente"'
Search Results
2. Monkeypox virus genomic accordion strategies
- Author
-
Monzón, Sara, Varona, Sarai, Negredo, Anabel, Vidal-Freire, Santiago, Patiño-Galindo, Juan Angel, Ferressini-Gerpe, Natalia, Zaballos, Angel, Orviz, Eva, Ayerdi, Oskar, Muñoz-Gómez, Ana, Delgado-Iribarren, Alberto, Estrada, Vicente, García, Cristina, Molero, Francisca, Sánchez-Mora, Patricia, Torres, Montserrat, Vázquez, Ana, Galán, Juan-Carlos, Torres, Ignacio, Causse del Río, Manuel, Merino-Diaz, Laura, López, Marcos, Galar, Alicia, Cardeñoso, Laura, Gutiérrez, Almudena, Loras, Cristina, Escribano, Isabel, Alvarez-Argüelles, Marta E., del Río, Leticia, Simón, María, Meléndez, María Angeles, Camacho, Juan, Herrero, Laura, Jiménez, Pilar, Navarro-Rico, María Luisa, Jado, Isabel, Giannetti, Elaina, Kuhn, Jens H., Sanchez-Lockhart, Mariano, Di Paola, Nicholas, Kugelman, Jeffrey R., Guerra, Susana, García-Sastre, Adolfo, Cuesta, Isabel, Sánchez-Seco, Maripaz P., and Palacios, Gustavo
- Published
- 2024
- Full Text
- View/download PDF
3. Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
- Author
-
Varona, Jose F, Landete, Pedro, Lopez-Martin, Jose A, Estrada, Vicente, Paredes, Roger, Guisado-Vasco, Pablo, de Orueta, Lucia Fernandez, Torralba, Miguel, Fortun, Jesus, Vates, Roberto, Barberan, Jose, Clotet, Bonaventura, Ancochea, Julio, Carnevali, Daniel, Cabello, Noemi, Porras, Lourdes, Gijon, Paloma, Monereo, Alfonso, Abad, Daniel, Zuñiga, Sonia, Sola, Isabel, Rodon, Jordi, Vergara-Alert, Julia, Izquierdo-Useros, Nuria, Fudio, Salvador, Pontes, Maria Jose, de Rivas, Beatriz, de Velasco, Patricia Giron, Nieto, Antonio, Gomez, Javier, Aviles, Pablo, Lubomirov, Rubin, Belgrano, Alvaro, Sopesen, Belen, White, Kris M, Rosales, Romel, Yildiz, Soner, Reuschl, Ann-Kathrin, Thorne, Lucy G, Jolly, Clare, Towers, Greg J, Zuliani-Alvarez, Lorena, Bouhaddou, Mehdi, Obernier, Kirsten, McGovern, Briana L, Rodriguez, M Luis, Enjuanes, Luis, Fernandez-Sousa, Jose M, Krogan, Nevan J, Jimeno, Jose M, and Garcia-Sastre, Adolfo
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Infectious Diseases ,Cancer ,Lung ,Clinical Trials and Supportive Activities ,Patient Safety ,Prevention ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Good Health and Well Being ,Adult ,Aged ,COVID-19 ,Cell Line ,Tumor ,Depsipeptides ,Drug Evaluation ,Preclinical ,Female ,Hospitalization ,Humans ,Kaplan-Meier Estimate ,Length of Stay ,Male ,Middle Aged ,Neutropenia ,Peptides ,Cyclic ,SARS-CoV-2 ,Treatment Outcome ,Viral Load ,COVID-19 Drug Treatment ,Biological sciences ,Biomedical and clinical sciences - Abstract
Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that plitidepsin distributes preferentially to lung over plasma, with similar potency against across several SARS-CoV-2 variants in preclinical studies. Simultaneously, in this randomized, parallel, open-label, proof-of-concept study (NCT04382066) conducted in 10 Spanish hospitals between May and November 2020, 46 adult hospitalized patients with confirmed SARS-CoV-2 infection received either 1.5 mg (n = 15), 2.0 mg (n = 16), or 2.5 mg (n = 15) plitidepsin once daily for 3 d. The primary objective was safety; viral load kinetics, mortality, need for increased respiratory support, and dose selection were secondary end points. One patient withdrew consent before starting procedures; 45 initiated treatment; one withdrew because of hypersensitivity. Two Grade 3 treatment-related adverse events were observed (hypersensitivity and diarrhea). Treatment-related adverse events affecting more than 5% of patients were nausea (42.2%), vomiting (15.6%), and diarrhea (6.7%). Mean viral load reductions from baseline were 1.35, 2.35, 3.25, and 3.85 log10 at days 4, 7, 15, and 31. Nonmechanical invasive ventilation was required in 8 of 44 evaluable patients (16.0%); six patients required intensive care support (13.6%), and three patients (6.7%) died (COVID-19-related). Plitidepsin has a favorable safety profile in patients with COVID-19.
- Published
- 2022
4. Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study
- Author
-
Sahner, David, Tierney, John, Vogel, Susan E., Herpin, Betsey R., Smolskis, Mary C., McKay, Laura A., Cahill, Kelly, Crew, Page, Sardana, Ratna, Raim, Sharon Segal, Hensely, Lisa, Lorenzo, Johsua, Mock, Rebecca, Zuckerman, Judith, Atri, Negin, Miller, Mark, Vallee, David, Chung, Lucy, Kang, Nayon, Barrett, Kevin, Adam, Stacey J., Read, Sarah, Draghia-Akli, Ruxandra, Currier, Judy, Hughes, Eric, Harrigan, Rachel H., Amos, Laura, Carlsen, Amy, Carter, Anita, Collins, Gary, Davis, Bionca, Denning, Eileen, DuChene, Alain, Eckroth, Kate, Engen, Nicole, Frase, Alex, Gandits, Greg, Grund, Birgit, Harrison, Merrie, Hurlbut, Nancy, Kaiser, Payton, Koopmeiners, Joseph, Larson, Gregg, Meger, Sue, Mistry, Shweta Sharma, Murray, Thomas, Nelson, Ray, Quan, Kien, Quan, Siu Fun, Reilly, Cavan, Siegel, Lianne, Thompson, Greg, Vock, David, Walski, Jamie, Gelijns, Annetine C., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, O'Sullivan, Karen, Marks, Mary E., Accardi, Evan, Kinzel, Emily, Burris, Sarah, Bedoya, Gabriela, Gupta, Lola, Overbey, Jessica R., Santos, Milerva, Gillinov, Marc A., Miller, Marissa A., Taddei-Peters, Wendy C., Fenton, Kathleen, Sandkovsky, Uriel, Gottlieb, Robert L., Mack, Michael, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Bettacchi, Christopher, Golden, Kevin, Duhaime, Erin, Ryan, Madison, Tallmadge, Catherine, Estrada, Lorie, Jones, Felecia, Villa, Samatha, Wang, Samatha, Robert, Raven, Coleman, Tanquinisha, Clariday, Laura, Baker, Rebecca, Hurutado-Rodriguez, Mariana, Iram, Nazia, Fresnedo, Michelle, Davis, Allyson, Leonard, Kiara, Ramierez, Noelia, Thammavong, Jon, Duque, Krizia, Turner, Emma, Fisher, Tammy, Robinson, Dianna, Ransom, Desirae, Maldonado, Nicholas, Lusk, Erica, Killian, Aaron, Palacious, Adriana, Solis, Edilia, Jerrow, Janet, Watts, Matthew, Whitacre, Heather, Cothran, Elizabeth, Smith, Peter K., Barkauskas, Christina E., Vekstein, Andrew M., Ko, Emily R., Dreyer, Grace R., Stafford, Neil, Brooks, Megan, Der, Tatyana, Witte, Marie, Gamarallage, Ruwan, Franzone, John, Ivey, Noel, Lumsden, Rebecca H., Mosaly, Nilima, Mourad, Ahmaad, Holland, Thomas L., Motta, Mary, Lane, Kathleen, McGowan, Lauren M., Stout, Jennifer, Aloor, Heather, Bragg, Kennesha M., Toledo, Barvina, McLendon-Arvik, Beth, Bussadori, Barbara, Hollister, Beth A., Griffin, Michelle, Giangiacomo, Dana M., Rodriguez, Vicente, Bokhart, Gordon, Eichman, Sharon M., Parrino, Patrick E., Spindel, Stephen, Bansal, Aditya, Baumgarten, Katherine, Hand, Johnathan, Vonderhaar, Derek, Nossaman, Bobby, Sylvia Laudun, Ames, DeAnna, Broussard, Shane, Hernandez, Nilmo, Isaac, Geralyn, Dinh, Huan, Zheng, Yiling, Tran, Sonny, McDaniel, Hunter, Crovetto, Nicolle, Perin, Emerson, Costello, Briana, Manian, Prasad, Sohail, M. Rizwan, Postalian, Alexander, Hinsu, Punit, Watson, Carolyn, Chen, James, Fink, Melyssa, Sturgis, Lydia, Walker, Kim, Mahon, Kim, Parenti, Jennifer, Kappenman, Casey, Knight, Aryn, Sturek, Jeffrey M., Barros, Andrew, Enfield, Kyle B., Kadl, Alexandra, Green, China J., Simon, Rachel M., Fox, Ashley, Thornton, Kara, Adams, Amy, Badhwar, Vinay, Sharma, Sunil, Peppers, Briana, McCarthy, Paul, Krupica, Troy, Sarwari, Arif, Reece, Rebecca, Fornaresico, Lisa, Glaze, Chad, Evans, Raquel, Di, Fang, Carlson, Shawn, Aucremanne, Tanja, Tennant, Connie, Sutton, Lisa Giblin, Buterbaugh, Sabrina, Williams, Roger, Bunner, Robin, Traverse, Jay H., Rhame, Frank, Huelster, Joshua, Kethireddy, Rajesh, Davies, Irena, Salamanca, Julianne, Majeski, Christine, Skelton, Paige, Zarambo, Maria, Sarafolean, Andrea, Bowdish, Michael E., Borok, Zea, Wald-Dickler, Noah, Hutcheon, Douglass, Towfighi, Amytis, Lee, Mary, Lewis, Meghan R., Spellberg, Brad, Sher, Linda, Sharma, Aniket, Olds, Anna P., Justino, Chris, Loxano, Edward, Romero, Chris, Leong, Janet, Rodina, Valentina, Quesada, Christine, Hamilton, Luke, Escobar, Jose, Leshnower, Brad, Bender, William, Sharifpour, Milad, Miller, Jeffrey, Farrington, Woodrow, Baio, Kim T., McBride, Mary, Fielding, Michele, Mathewson, Sonya, Porte, Kristina, Maton, Missy, Ponder, Chari, Haley, Elisabeth, Spainhour, Christine, Rogers, Susan, Tyler, Derrick, Madathil, Ronson J., Rabin, Joseph, Levine, Andrea, Saharia, Kapil, Tabatabai, Ali, Lau, Christine, Gammie, James S., Peguero, Maya-Loren, McKernan, Kimberly, Audette, Mathew, Fleischmann, Emily, Akbari, Kreshta, Lee, Myounghee, Chi, Andrew, Salehi, Hanna, Pariser, Alan, Nyguyen, Phuong Tran, Moore, Jessica, Gee, Adrienne, Vincent, Shelika, Zuckerman, Richard A., Iribarne, Alexander, Metzler, Sara, Shipman, Samantha, Johnson, Haley, Newton, Crystallee, Parr, Doug, Miller, Leslie, Schelle, Beth, McLean, Sherry, Rothbaum, Howard R., Alvarez, Michael S., Kalan, Shivam P., Germann, Heather H., Hendershot, Jennifer, Moroney, Karen, Herring, Karen, Cook, Sharri, Paul, Pam, Walker-Ignasiak, Rebecca, North, Crystal, Oldmixon, Cathryn, Ringwood, Nancy, Muzikansky, Ariela, Morse, Richard, Fitzgerald, Laura, Morin, Haley D., Brower, Roy G., Reineck, Lora A., Bienstock, Karen, Steingrub, Jay H., Hou, Peter K., Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Leslie, Romain, Sarah, Thornton-Thompson, Sherell, Talmor, Daniel, Shapiro, Nathan, Andromidas, Konstantinos, Banner-Goodspeed, Valerie, Bolstad, Michael, Boyle, Katherine L., Cabrera, Payton, deVilla, Arnaldo, Ellis, Joshua C., Grafals, Ana, Hayes, Sharon, Higgins, Conor, Kurt, Lisa, Kurtzman, Nicholas, Redman, Kimberly, Rosseto, Elinita, Scaffidi, Douglas, Filbin, Michael R., Hibbert, Kathryn A., Parry, Blair, Margolin, Justin, Hillis, Brooklynn, Hamer, Rhonda, Brait, Kelsey, Beakes, Caroline, McKaig, Brenna, Kugener, Eleonore, Jones, Alan E., Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Hendey, Gregory, Kangelaris, Kirsten, Ashktorab, Kimia, Gropper, Rachel, Agrawal, Anika, Yee, Kimberley J., Jauregui, Alejandra E., Zhuo, Hanjing, Almasri, Eyad, Fayed, Mohamed, Hubel, Kinsley A., Hughes, Alyssa R., Garcia, Rebekah L., Lim, George W., Chang, Steven Y., Lin, Michael Y., Vargas, Julia, Sihota, Hena, Beutler, Rebecca, Agarwal, Trisha, Wilson, Jennifer G., Vojnik, Rosemary, Perez, Cynthia, McDowell, Jordan H., Roque, Jonasel, Wang, Henry, Huebinger, Ryan M., Patel, Bela, Vidales, Elizabeth, Albertson, Timothy, Hardy, Erin, Harper, Richart, Moss, Marc A., Baduashvili, Amiran, Chauhan, Lakshmi, Douin, David J., Martinez, Flora, Finck, Lani L., Bastman, Jill, Howell, Michelle, Higgins, Carrie, McKeehan, Jeffrey, Finigan, Jay, Stubenrauch, Peter, Janssen, William J., Griesmer, Christine, VerBurg, Olivia, Hyzy, Robert C., Park, Pauline K., Nelson, Kristine, McSparron, Jake I., Co, Ivan N., Wang, Bonnie R., Jimenez, Jose, Olbrich, Norman, McDonough, Kelli, Jia, Shijing, Hanna, Sinan, Gong, Michelle N., Richardson, Lynne D., Nair, Rahul, Lopez, Brenda, Amosu, Omowunmi, Offor, Obiageli, Tzehaie, Hiwet, Nkemdirim, William, Boujid, Sabah, Mosier, Jarrod M., Hypes, Cameron, Campbell, Elizabeth Salvagio, Bixby, Billie, Gilson, Boris, Lopez, Anitza, Bime, Christian, Parthasarathy, Sairam, Cano, Ariana M., Hite, R. Duncan, Terndrup, Thomas E., Wiedemann, Herbert P., Hudock, Kristin, Tanzeem, Hammad, More, Harshada, Martinkovic, Jamie, Sellers, Susan, Houston, Judy, Burns, Mary, Kiran, Simra, Roads, Tammy, Kennedy, Sarah, Duggal, Abhijit, Thiruchelvam, Nirosshan, Ashok, Kiran, King, Alexander H., Mehkri, Omar, Dugar, Siddharth, Sahoo, Debasis, Yealy, Donald M., Angus, Derek C., Weissman, Alexandra J., Vita, Tina M., Berryman, Emily, Hough, Catherine L., Khan, Akram, Krol, Olivia F., Mills, Emmanuel, Kinjal, Mistry, Briceno, Genesis, Reddy, Raju, Hubel, Kinsley, Jouzestani, Milad K., McDougal, Madeline, Deshmukh, Rupali, Johnston, Nicholas J., Robinson, Bryce H., Gundel, Staphanie J., Katsandres, Sarah C., Chen, Peter, Torbati, Sam S., Parimon, Tanyalak, Caudill, Antonina, Mattison, Brittany, Jackman, Susan E., Chen, Po-En, Bayoumi, Emad, Ojukwu, Cristabelle, Fine, Devin, Weissberg, Gwendolyn, Isip, Katherine, Choi-Kuaea, Yunhee, Mehdikhani, Shaunt, Dar, Tahir B., Fleury Augustin, Nsole Biteghe, Tran, Dana, Dukov, Jennifer Emilow, Matusov, Yuri, Choe, June, Hindoyan, Niree A., Wynter, Timothy, Pascual, Ethan, Clapham, Gregg J., Herrera, Lisa, Caudill, Antonia, O’Mahony, D. Shane, Nyatsatsang, Sonam T., Wilson, David M., Wallick, Julie A., Duven, Alexandria M., Fletcher, Dakota D., Miller, Chadwick, Files, D. Clark, Gibbs, Kevin W., Flores, Lori S., LaRose, Mary E., Landreth, Leigha D., Palacios, D. Rafael, Parks, Lisa, Hicks, Madeline, Goodwin, Andrew J., Kilb, Edward F., Lematty, Caitlan T., Patti, Kerilyn, Grady, Abigail, Rasberry, April, Morris, Peter E., Sturgill, Jamie L., Cassity, Evan P., Dhar, Sanjay, Montgomery-Yates, Ashley A., Pasha, Sarah N., Mayer, Kirby P., Pharm.D., Brittany Bissel, Trott, Terren, Rehman, Shahnaz, de Wit, Marjolein, Mason, Jessica, Bledsoe, Joseph, Knowlton, Kirk U., Brown, Samuel, Lanspa, Michael, Leither, Lindsey, Pelton, Ithan, Armbruster, Brent P., Montgomery, Quinn, Kumar, Naresh, Fergus, Melissa, Imel, Karah, Palmer, Ghazal, Webb, Brandon, Klippel, Carolyn, Jensen, Hannah, Duckworth, Sarah, Gray, Andrew, Burke, Tyler, Knox, Dan, Lumpkin, Jenna, Aston, Valerie T., Applegate, Darrin, Serezlic, Erna, Brown, Katie, Merril, Mardee, Harris, Estelle S., Middleton, Elizabeth A., Barrios, Macy A.G., Greer, Jorden, Schmidt, Amber D., Webb, Melissa K., Paine, Roert, Callahan, Sean J., Waddoups, Lindsey J., Yamane, Misty B., Self, Wesley H., Rice, Todd W., Casey, Jonathan D., Johnson, Jakea, Gray, Christopher, Hays, Margaret, Roth, Megan, Menon, Vidya, Kasubhai, Moiz, Pillai, Anjana, Daniel, Jean, Sittler, Daniel, Kanna, Balavenkatesh, Jilani, Nargis, Amaro, Francisco, Santana, Jessica, Lyakovestsky, Aleksandr, Madhoun, Issa, Desroches, Louis Marie, Amadon, Nicole, Bahr, Alaa, Ezzat, Imaan, Guerrero, Maryanne, Padilla, Joane, Fullmer, Jessie, Singh, Inderpreet, Ali Shah, Syed Hamad, Narang, Rajeev, Mock, Polly, Shadle, Melissa, Hernandez, Brenda, Welch, Kevin, Payne, Andrea, Ertl, Gabriela, Canario, Daniel, Barrientos, Isabel, Goss, Danielle, DeVries, Mattie, Folowosele, Ibidolapo, Garner, Dorothy, Gomez, Mariana, Price, Justin, Bansal, Ekta, Wong, Jim, Faulhaber, Jason, Fazili, Tasaduq, Yeary, Brian, Ndolo, Ruth, Bryant, Christina, Smigeil, Bridgette, Robinson, Philip, Najjar, Rana, Jones, Patrice, Nguyen, Julie, Chin, Christina, Taha, Hassan, Najm, Salah, Smith, Christopher, Moore, Jason, Nassar, Talal, Gallinger, Nick, Christian, Amy, Mauer, D’Amber, Phipps, Ashley, Waters, Michael, Zepeda, Karla, Coslet, Jordan, Landazuri, Rosalynn, Pineda, Jacob, Uribe, Nicole, Garcia, Jose Ruiz, Barbabosa, Cecilia, Sandler, Kaitlyn, Overcash, J. Scott, Marquez, Adrienna, Chu, Hanh, Lee, Kia, Quillin, Kimberly, Garcia, Andrea, Lew, Pauline, Rogers, Ralph, Shehadeh, Fadi, Mylona, Evangelia K., Kaczynski, Matthew, Tran, Quynh-Lam, Benitez, Gregorio, Mishra, Biswajit, Felix, Lewis Oscar, Vafea, Maria Tsikala, Atalla, Eleftheria, Davies, Robin, Hedili, Salma, Monkeberg, Maria Andrea, Tabler, Sandra, Harrington, Britt, Meegada, Sreenath, Koripalli, Venkata Sandeep, Muddana, Prithvi, Jain, Lakshay, Undavalli, Chaitanya, Kavya, Parasa, Ibiwoye, Mofoluwaso, Akilo, Hameed, Lovette, Bryce D., Wylie, Jamie-Crystal, Smith, Diana M., Poon, Kenneth, Eckardt, Paula, Heysu, Rubio-Gomez, Sundararaman, Nithya, Alaby, Doris, Sareli, Candice, Sánchez, Adriana, Popielski, Laura, Kambo, Amy, Viens, Kimberley, Turner, Melissa, Vjecha, Michael J., Weintrob, Amy, Brar, Indira, Markowitz, Norman, Pastor, Erika, Corpuz, Roweena, Alangaden, George, McKinnon, John, Ramesh, Mayur, Herc, Erica, Yared, Nicholas, Lanfranco, Odaliz Abreu, Rivers, Emanuel, Swiderek, Jennifer, Gupta, Ariella Hodari, Pabla, Pardeep, Eliya, Sonia, Jazrawi, Jehan, Delor, Jeremy, Desai, Mona, Cook, Aaron, Jaehne, Anja Kathrina, Gill, Jasreen Kaur, Renaud, Sheri, Sarveswaran, Siva, Gardner, Edward, Scott, James, Bianchini, Monica, Melvin, Casey, Kim, Gina, Wyles, David, Kamis, Kevin, Miller, Rachel, Douglas, Ivor, Haukoos, Jason, Hicks, Carrie, Lazarte, Susana, Marines-Price, Rubria, Osuji, Alice, Agbor Agbor, Barbine Tchamba, Petersen, Tianna, Kamel, Dena, Hansen, Laura, Garcia, Angie, Cha, Christine, Mozaffari, Azadeh, Hernandez, Rosa, Cutrell, James, Kim, Mina, DellaValle, Natalie, Gonzales, Sonia, Somboonwit, Charurut, Oxner, Asa, Guerra, Lucy, Hayes, Michael, Nguyen, Thi, Tran, Thanh, Pinto, Avenette, Hatlen, Timothy, Anderson, Betty, Zepeda-Gutierrez, Ana, Martin, Dannae, Temblador, Cindi, Cuenca, Avon, Tanoviceanu, Roxanne, Prieto, Martha, Guerrero, Mario, Daar, Eric, Correa, Ramiro, Hartnell, Gabe, Wortmann, Glenn, Doshi, Saumil, Moriarty, Theresa, Gonzales, Melissa, Garman, Kristin, Baker, Jason V., Frosch, Anne, Goldsmith, Rachael, Driver, Brian, Frank, Christine, Leviton, Tzivia, Prekker, Matthew, Jibrell, Hodan, Lo, Melanie, Klaphake, Jonathan, Mackedanz, Shari, Ngo, Linh, Garcia-Myers, Kelly, Kunisaki, Ken M., Wendt, Chris, Melzer, Anne, Wetherbee, Erin, Drekonja, Dimitri, Pragman, Alexa, Hamel, Aimee, Thielen, Abbie, Hassler, Miranda, Walquist, Mary, Augenbraun, Michael, George, Jensen, Demeo, Lynette, Mishko, Motria, Thomas, Lorraine, Tatem, Luis, Dehovitz, Jack, Abassi, Mahsa, Leuck, Anne-Marie, Rao, Via, Pullen, Matthew, Luke, Darlette, LaBar, Derek, Christiansen, Theresa, Howard, Diondra, Biswas, Kousick, Harrington, Cristin, Garcia, Amanda, Bremer, Tammy, Burke, Tara, Koker, Brittany, Davis-Karim, Anne, Pittman, David, Vasudeva, Shikha S., Johnstone, Jaylynn R., Agnetti, Kate, Davis, Ruby, Trautner, Barbara, Hines-Munson, Casey, Van, John, Dillon, Laura, Wang, Yiqun, Nagy-Agren, Stephanie, Vasudeva, Shikha, Ochalek, Tracy, Caldwell, Erin, Humerickhouse, Edward, Boone, David, McGraw, William, Looney, David J., Mehta, Sanjay R., Johns, Scott Thompson, St. John, Melissa, Raceles, Jacqueline, Sear, Emily, Funk, Stephen, Cesarini, Rosa, Fang, Michelle, Nicalo, Keith, Drake, Wonder, Jones, Beatrice, Holtman, Teresa, Nguyen, Hien H., Maniar, Archana, Johnson, Eric A., Nguyen, Lam, Tran, Michelle T., Barrett, Thomas W., Johnston, Tera, Huggins, John T., Beiko, Tatsiana Y., Hughes, Heather Y., McManigle, William C., Tanner, Nichole T., Washburn, Ronald G., Ardelt, Magdalena, Tuohy, Patricia A., Mixson, Jennifer L., Hinton, Charles G., Thornley, Nicola, Allen, Heather, Elam, Shannon, Boatman, Barry, Baber, Brittany J., Ryant, Rudell, Roller, Brentin, Nguyen, Chinh, Mikail, Amani Morgan, Research, Marivic Hansen, Lichtenberger, Paola, Baracco, Gio, Ramos, Carol, Bjork, Lauren, Sueiro, Melyssa, Tien, Phyllis, Freasier, Heather, Buck, Theresa, Nekach, Hafida, Holodniy, Mark, Chary, Aarthi, Lu, Kan, Peters, Theresa, Lopez, Jessica, Tan, Susanna Yu, Lee, Robert H., Asghar, Aliya, Karyn Isip, Tasadduq Karim, Le, Katherine, Nguyen, Thao, Wong, Shinn, Raben, Dorthe, Murray, Daniel D., Jensen, Tomas O., Peters, Lars, Aagaard, Bitten, Nielsen, Charlotte B., Krapp, Katharina, Nykjær, Bente Rosdahl, Olsson, Christina, Kanne, Katja Lisa, Grevsen, Anne Louise, Joensen, Zillah Maria, Bruun, Tina, Bojesen, Ane, Woldbye, Frederik, Normand, Nick E., Esman, Frederik V.L., Benfield, Thomas, Clausen, Clara Lundetoft, Hovmand, Nichlas, Israelsen, Simone Bastrup, Iversen, Katrine, Leding, Caecilie, Pedersen, Karen Brorup, Thorlacius-Ussing, Louise, Tinggaard, Michaela, Tingsgard, Sandra, Krohn-Dehli, Louise, Pedersen, Dorthe, Villadsen, Signe, Staehr Jensen, Jens-Ulrik, Overgaard, Rikke, Rastoder, Ema, Heerfordt, Christian, Hedsund, Caroline, Ronn, Christian Phillip, Kamstrup, Peter Thobias, Hogsberg, Dorthe Sandbaek, Bergsoe, Christina, Søborg, Christian, Hissabu, Nuria M.S., Arp, Bodil C., Ostergaard, Lars, Staerke, Nina Breinholt, Yehdego, Yordanos, Sondergaard, Ane, Johansen, Isik S., Pedersen, Andreas Arnholdt, Knudtzen, Fredrikke C., Larsen, Lykke, Hertz, Mathias A., Fabricius, Thilde, Holden, Inge K., Lindvig, Susan O., Helleberg, Marie, Gerstoft, Jan, Kirk, Ole, Jensen, Tomas Ostergaard, Madsen, Birgitte Lindegaard, Pedersen, Thomas Ingemann, Harboe, Zitta Barrella, Roge, Birgit Thorup, Hansen, Thomas Michael, Glesner, Matilde Kanstrup, Lofberg, Sandra Valborg, Nielsen, Ariella Denize, Leicht von Huth, Sebastian, Nielsen, Henrik, Thisted, Rikke Krog, Petersen, Kristine Toft, Juhl, Maria Ruwald, Podlekareva, Daria, Johnsen, Stine, Andreassen, Helle Frost, Pedersen, Lars, Clara Ellinor Lindnér, Cecilia Ebba, Wiese, Lothar, Knudsen, Lene Surland, Skrøder Nytofte, Nikolaj Julian, Havmøller, Signe Ravn, Expósito, Maria, Badillo, José, Martínez, Ana, Abad, Elena, Chamorro, Ana, Figuerola, Ariadna, Mateu, Lourdes, España, Sergio, Lucero, Maria Constanza, Santos, José Ramón, Lladós, Gemma, Lopez, Cristina, Carabias, Lydia, Molina-Morant, Daniel, Loste, Cora, Bracke, Carmen, Siles, Adrian, Fernández-Cruz, Eduardo, Di Natale, Marisa, Padure, Sergiu, Gomez, Jimena, Ausin, Cristina, Cervilla, Eva, Balastegui, Héctor, Sainz, Carmen Rodríguez, Lopez, Paco, Carbone, Javier, Escobar, Mariam, Balerdi, Leire, Legarda, Almudena, Roldan, Montserrat, Letona, Laura, Muñoz, José, Camprubí, Daniel, Arribas, Jose R., Sánchez, Rocio Montejano, Díaz-Pollán, Beatriz, Stewart, Stefan Mark, Garcia, Irene, Borobia, Alberto, Mora-Rillo, Marta, Estrada, Vicente, Cabello, Noemi, Nuñez-Orantos, M.J., Sagastagoitia, I., Homen, J.R., Orviz, E., Montalvá, Adrián Sánchez, Espinosa-Pereiro, Juan, Bosch-Nicolau, Pau, Salvador, Fernando, Burgos, Joaquin, Morales-Rull, Jose Luis, Moreno Pena, Anna Maria, Acosta, Cristina, Solé-Felip, Cristina, Horcajada, Juan P., Sendra, Elena, Castañeda, Silvia, López-Montesinos, Inmaculada, Gómez-Junyent, Joan, Gonzáles, Carlota Gudiol, Cuervo, Guilermo, Pujol, Miquel, Carratalà, Jordi, Videla, Sebastià, Günthard, Huldrych, Braun, Dominique L., West, Emily, M’Rabeth-Bensalah, Khadija, Eichinger, Mareile L., Grüttner-Durmaz, Manuela, Grube, Christina, Zink, Veronika, pharmacist, Goes pharmacist, Josefine, Fätkenheuer, Gerd, Malin, Jakob J., Tsertsvadze, Tengiz, Abutidze, Akaki, Chkhartishvili, Nikoloz, Metchurtchlishvili, Revaz, Endeladze, Marina, Paciorek, Marcin, Bursa, Dominik, Krogulec, Dominika, Pulik, Piotr, Ignatowska, Anna, Horban, Andrzej, Bakowska, Elzbieta, Kowaska, Justyna, Bednarska, Agnieszka, Jurek, Natalia, Skrzat-Klapaczynska, Agata, Bienkowski, Carlo, Hackiewicz, Malgorzata, Makowiecki, Michal, Platowski, Antoni, Fishchuk, Roman, Kobrynska, Olena, Levandovska, Khrystyna, Kirieieva, Ivanna, Kuziuk, Mykhailo, Naucler, Pontus, Perlhamre, Emma, Mazouch, Lotta, Kelleher, Anthony, Polizzotto, Mark, Carey, Catherine, Chang, Christina C., Hough, Sally, Virachit, Sophie, Davidson, Sarah, Bice, Daniel J., Ognenovska, Katherine, Cabrera, Gesalit, Flynn, Ruth, Young, Barnaby E., Chia, Po Ying, Lee, Tau Hong, Lin, Ray J., Lye, David C., Ong, Sean W.X., Puah, Ser Hon, Yeo, Tsin Wen, Diong, Shiau Hui, Ongko, Juwinda, Yeo, He Ping, Eriobu, Nnakelu, Kwaghe, Vivian, Zaiyad, Habib, Idoko, Godwin, Uche, Blessing, Selvamuthu, Poongulali, Kumarasamy, Nagalingeswaran, Beulah, Faith Ester, Govindarajan, Narayan, Mariyappan, Kowsalya, Losso, Marcelo H., Abela, Cecilia, Moretto, Renzo, Belloc, Carlos G., Ludueña, Jael, Amar, Josefina, Toibaro, Javier, Macias, Laura Moreno, Fernandez, Lucia, Frare, Pablo S., Chaio, Sebastian R., Pachioli, Valeria, Timpano, Stella M., Sanchez, Marisa del Lujan, de Paz Sierra, Mariana, Stanek, Vanina, Belloso, Waldo, Cilenti, Flavia L., Valentini, Ricardo N., Stryjewski, Martin E., Locatelli, Nicolas, Soler Riera, Maria C., Salgado, Clara, Baeck, Ines M., Di Castelnuovo, Valentina, Zarza, Stella M., Hudson, Fleur, Parmar, Mahesh K.B., Goodman, Anna L., Dphil, Badrock, Jonathan, Gregory, Adam, Goodall, Katharine, Harris, Nicola, Wyncoll, James, Bhagani, S., Rodger, A., Luntiel, A., Patterson, C., Morales, J., Witele, E., Preston, A.-M., Nandani, A., Price, D.A., Hanrath, Aiden, Nell, Jeremy, Patel, Bijal, Hays, Carole, Jones, Geraldine, Davidson, Jade, Bawa, T., Mathews, M., Mazzella, A., Bisnauthsing, K., Aguilar-Jimenez, L., Borchini, F., Hammett, S., Touloumi, Giota, Pantazis, Nikos, Gioukari, Vicky, Souliou, Tania, Antoniadou, A., Protopapas, K., Kavatha, D., Grigoropoulou, S., Oikonomopoulo, C., Moschopoulos, C., Koulouris, N.G., Tzimopoulos, K., Koromilias, A., Argyraki, K., Lourida, P., Bakakos, P., Kalomenidis, I., Vlachakos, V., Barmparessou, Z., Balis, E., Zakynthinos, S., Sigala, I., Gianniou, N., Dima, E., Magkouta, S., Synolaki, E., Konstanta, S., Vlachou, M., Stathopoulou, P., Panagopoulos, P., Petrakis, V., Papazoglou, D., Tompaidou, E., Isaakidou, E., Poulakou, G., Rapti, V., Leontis, K., Nitsotolis, T., Athanasiou, K., Syrigos, K., Kyriakoulis, K., Trontzas, I., Arfara-Melanini, M., Kolonis, V., Kityo, Cissy, Mugerwa, Henry, Kiweewa, Francis, Kimuli, Ivan, Lukaakome, Joseph, Nsereko, Christoher, Lubega, Gloria, Kibirige, Moses, Nakahima, William, Wangi, Deus, Aguti, Evelyne, Generous, Lilian, Massa, Rosemary, Nalaki, Margaret, Magala, Felix, Nabaggala, Phiona Kaweesi, Kidega, Robert, Faith, Oryem Daizy, Florence, Apio, Emmanuel, Ocung, Beacham, Mugoonyi Paul, Geoffrey, Amone, Nakiboneka, Dridah, Apiyo, Paska, Kirenga, Bruce, Atukunda, Angella, Muttamba, Winters, Remmy, Kyeyume, Segawa, Ivan, Pheona, Nsubuga, Kigere, David, Mbabazi, Queen Lailah, Boersalino, Ledra, Nyakoolo, Grace, Fred, Aniongo, Alupo, Alice, Ebong, Doryn, Monday, Edson, Nalubwama, Ritah Norah, Kainja, Milton, Ambrose, Munu, Kwehayo, Vanon, Nalubega, Mary Grace, Ongoli, Augustine, Obbo, Stephen, Sebudde, Nicholus, Alaba, Jeniffer, Magombe, Geoffrey, Tino, Harriet, Obonya, Emmanuel, Lutaakome, Joseph, Kitonsa, Jonathan, Onyango, Martin, Naboth, Tukamwesiga, Naluyinda, Hadijah, Nanyunja, Regina, Irene, Muttiibwa, Jane, Biira, Wimfred, Kyobejja, Leonard, Ssemazzi, Deus, Tkiinomuhisha, Babra, Namasaba, Taire, Paul, Nabankema, Evelyn, Ogavu, Joseph, Mugerwa, Oscar, Okoth, Ivan, Mwebaze, Raymond, Mugabi, Timothy, Makhoba, Anthony, Arikiriza, Phiona, Theresa, Nabuuma, Nakayima, Hope, Frank, Kisuule, Ramgi, Patrícia, Pereira, Kássia, Osinusi, Anu, Cao, Huyen, Klekotka, Paul, Price, Karen, Nirula, Ajay, Osei, Suzette, Tipple, Craig, Wills, Angela, Peppercorn, Amanda, Watson, Helen, Gupta, Rajesh, Alexander, Elizabeth, Mogalian, Erik, Lin, Leo, Ding, Xiao, Margolis, David, Yan, Li, Girardet, Jean-Luc, Ma, Ji, Hong, Zhi, Zhu, Quing, Seegobin, Seth, Gibbs, Michael, Latchman, Mickel, Hasior, Katarzyna, Bouquet, Jerome, Wei, Jianxin, Streicher, Katie, Schmelzer, Albert, Brooks, Dennis, Butcher, Jonny, Tonev, Dimitar, Arbetter, Douglas, Damstetter, Philippe, Legenne, Philippe, Stumpp, Michael, Goncalves, Susana, Ramanathan, Krishnan, Chandra, Richa, Baseler, Beth, Teitelbaum, Marc, Schechner, Adam, Holley, H. Preston, Jankelevich, Shirley, Becker, Nancy, Dolney, Suzanne, Hissey, Debbie, Simpson, Shelly, Kim, Mi Ha, Beeler, Joy, Harmon, Liam, Asomah, Mabel, Jato, Yvonne, Stottlemyer, April, Tang, Olivia, Vanderpuye, Sharon, Yeon, Lindsey, Buehn, Molly, Eccard-Koons, Vanessa, Frary, Sadie, MacDonald, Leah, Cash, Jennifer, Hoopengardner, Lisa, Linton, Jessica, Schaffhauser, Marylu, Nelson, Michaela, Spinelli-Nadzam, Mary, Proffitt, Calvin, Lee, Christopher, Engel, Theresa, Fontaine, Laura, Osborne, C.K., Hohn, Matt, Galcik, Michael, Thompson, DeeDee, Kopka, Stacey, Shelley, Denise M., Mendez, Gregg, Brown, Shawn, Albert, Sara, Balde, Abby, Baracz, Michelle, Bielica, Mona, Billouin-Frazier, Shere, Choudary, Jay, Dixon, Mary, Eyler, Carolyn, Frye, Leanne, Gertz, Jensen, Giebeig, Lisa, Gulati, Neelam, Hankinson, Liz, Hogarty, Debi, Huber, Lynda, Krauss, Gary, Lake, Eileen, Manandhar, Meryan, Rudzinski, Erin, Sandrus, Jen, Suders, Connie, Natarajan, Ven, Rupert, Adam W., Baseler, Michael, Lynam, Danielle, Imamichi, Tom, Laverdure, Sylvain, McCormack, Ashley, Paudel, Sharada, Cook, Kyndal, Haupt, Kendra, Khan, Ayub, Hazen, Allison, Badralmaa, Yunden, Smith, Kenneth, Patel, Bhakti, Kubernac, Amanda, Kubernac, Robert, Hoover, Marie L., Solomon, Courtney, Rashid, Marium, Murphy, Joseph, Brown, Craig, DuChateau, Nadine, Ellis, Sadie, Flosi, Adam, Fox, Lisa, Johnson, Les, Nelson, Rich, Stojanovic, Jelena, Treagus, Amy, Wenner, Christine, Williams, Richard, Jensen, Tomas O, Murray, Thomas A, Grandits, Greg A, Jain, Mamta K, Shaw-Saliba, Kathryn, Matthay, Michael A, Baker, Jason V, Dewar, Robin L, Goodman, Anna L, Hatlen, Timothy J, Highbarger, Helene C, Lallemand, Perrine, Leshnower, Bradley G, Looney, David, Moschopoulos, Charalampos D, Murray, Daniel D, Mylonakis, Eleftherios, Rehman, M Tauseef, Rupert, Adam, Stevens, Randy, Turville, Stuart, Wick, Katherine, Lundgren, Jens, and Ko, Emily R
- Published
- 2024
- Full Text
- View/download PDF
5. Cardiovascular Risk and Health Among People With Human Immunodeficiency Virus (HIV) Eligible for Primary Prevention: Insights From the REPRIEVE Trial
- Author
-
Douglas, Pamela S, Umbleja, Triin, Bloomfield, Gerald S, Fichtenbaum, Carl J, Zanni, Markella V, Overton, Edgar T, Fitch, Kathleen V, Kileel, Emma M, Aberg, Judith A, Currier, Judith, Sponseller, Craig A, Melbourne, Kathleen, Avihingsanon, Anchalee, Bustorff, Flavio, Estrada, Vicente, Ruxrungtham, Kiat, Saumoy, Maria, Navar, Ann Marie, Hoffmann, Udo, Ribaudo, Heather J, and Grinspoon, Steven
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,HIV/AIDS ,Cardiovascular ,Clinical Research ,Clinical Trials and Supportive Activities ,Infection ,Good Health and Well Being ,Blood Glucose ,Body Mass Index ,Cardiovascular Diseases ,Female ,HIV ,HIV Infections ,Heart Disease Risk Factors ,Humans ,Male ,Risk Factors ,atherosclerotic cardiovascular disease ,cardiac prevention ,cardiovascular health ,cardiovascular risk ,lifestyle modifications ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Clinical sciences - Abstract
BackgroundIn addition to traditional cardiovascular (CV) risk factors, antiretroviral therapy, lifestyle, and human immunodeficiency virus (HIV)-related factors may contribute to future CV events in persons with HIV (PWH).MethodsAmong participants in the global REPRIEVE randomized trial, we characterized demographics and HIV characteristics relative to ACC/AHA pooled cohort equations (PCE) for atherosclerotic CV disease predicted risk and CV health evaluated by Life's Simple 7 (LS7; includes smoking, diet, physical activity, body mass index, blood pressure, total cholesterol, and glucose).ResultsAmong 7382 REPRIEVE participants (31% women, 45% Black), the median PCE risk score was 4.5% (lower and upper quartiles Q1, Q3: 2.2, 7.2); 29% had a PCE score
- Published
- 2021
6. Clinical outcomes by supplemental oxygen use in remdesivir-treated, hospitalised adults with COVID-19
- Author
-
Arber, Nadir, Shah, Pallav L., Assoumou, Lambert, Rokx, Casper, De Castro, Nathalie, Bakhai, Ameet, Soriano Viladomiu, Alex, Mateu, Lourdes, Lumbreras, Carlos, Estrada, Vicente, Curran, Adrian, Sellier, Pierre-Olivier, Duffy, Annie, Fletcher, Carl, Mozaffari, Essy, Haubrich, Richard, Hodgkins, Paul, Pozniak, Anton, and Raffi, Francois
- Published
- 2023
- Full Text
- View/download PDF
7. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events
- Author
-
Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio
- Published
- 2023
- Full Text
- View/download PDF
8. Monitoring monkeypox virus in saliva and air samples in Spain: a cross-sectional study
- Author
-
Hernaez, Bruno, Muñoz-Gómez, Ana, Sanchiz, Africa, Orviz, Eva, Valls-Carbo, Adrian, Sagastagoitia, Iñigo, Ayerdi, Oskar, Martín, Rocío, Puerta, Teresa, Vera, Mar, Cabello, Noemi, Vergas, Jorge, Prieto, Cristina, Pardo-Figuerez, María, Negredo, Anabel, Lagarón, José María, del Romero, Jorge, Estrada, Vicente, and Alcamí, Antonio
- Published
- 2023
- Full Text
- View/download PDF
9. Monkeypox outbreak in Madrid (Spain): Clinical and virological aspects
- Author
-
Ballesteros, Juan, Baza, Begoña, Carrió, Juan Carlos, Chocron, Cynthia, Fedele, Giovanni, García-Amil, Cristina, Herrero, Laura, Homen, Reynaldo, Mariano, Alberto, Martínez-Burgoa, Teresa, Molero, Francisca, Navarro, Maria Luisa, Núñez, Maria José, Perez-Somarriba, Juncal, Puerta, Teresa, Rodríguez-Añover, Javier, Pastrana, Esperanza Pérez, Jiménez, Mercedes, de la Vega, Leticia, Vergas, Jorge, Zarza, Isabel, Orviz, Eva, Negredo, Anabel, Ayerdi, Oskar, Vázquez, Ana, Muñoz-Gomez, Ana, Monzón, Sara, Clavo, Petunia, Zaballos, Angel, Vera, Mar, Sánchez, Patricia, Cabello, Noemi, Jiménez, Pilar, Pérez-García, Jorge A., Varona, Sarai, del Romero, Jorge, Cuesta, Isabel, Delgado-Iribarren, Alberto, Torres, Montse, Sagastagoitia, Iñigo, Palacios, Gustavo, Estrada, Vicente, and Sánchez-Seco, Maria Paz
- Published
- 2022
- Full Text
- View/download PDF
10. Shorter Time to Discontinuation Due to Treatment Failure in People Living with HIV Switched to Dolutegravir Plus Either Rilpivirine or Lamivudine Compared with Integrase Inhibitor-Based Triple Therapy in a Large Spanish Cohort
- Author
-
Teira, Ramón, Diaz-Cuervo, Helena, Aragão, Filipa, Castaño, Manuel, Romero, Alberto, Roca, Bernardino, Montero, Marta, Galindo, Maria José, Muñoz-Sánchez, Maria Jose, Espinosa, Nuria, Peraire, Joaquim, Martínez, Elisa, de la Fuente, Belén, Domingo, Pere, Deig, Elisabeth, Merino, María Dolores, Geijo, Paloma, Estrada, Vicente, Sepúlveda, María Antonia, García, Josefina, Berenguer, Juan, and Currán, Adriá
- Published
- 2022
- Full Text
- View/download PDF
11. Epidemiologic and Economic Analysis of Rapid Antiretroviral Therapy Initiation with Bictegravir/Emtricitabine/Tenofovir Alafenamide in Spain
- Author
-
Estrada, Vicente, Górgolas, Miguel, Peña, José A., Tortajada, Elena, Castro, Antonio, Presa, María, and Oyagüez, Itziar
- Published
- 2022
- Full Text
- View/download PDF
12. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses
- Author
-
Pan, Hongchao, Peto, Richard, Henao Restrepo, Ana Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Karim, Quarraisha Abdool, Alejandria, Marissa, Hernàndez García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K. Srinath, Periago, Mirta Roses, Hanna, Pierre Abi, Abutidze, Akaki, Ader, Florence, Al-Bader, Abdullah, Alhasawi, Almonther, Allum, Emma, Al Mawali, Adhra, Alotaibi, Athari, Alvarez- Moreno, Carlos, Appadoo, Sheila, Arts, Derk, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Genetu Bayih, Abebe, Beaumont, Helena, Bellani, Samir, Benassi, Virginia, Bhargava, Balram, Branca, Mattia, Cappel-Porter, Heike, Cerrato, Nery, Cheick Haidara, Fadima, Chow, Ting Soo, Como, Nadia, Eustace, Joe, Gabunia, Tamar, García, Patricia, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Khamis, Faryal, Kirwan, Jana, Kumar, Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Manevska, Suzana, Manuel, Oriol, McGinty, Sybil, Medina, Marco, Mesa Rubio, Maria Lucia, Miranda Montoya, Maria Consuelo, Nel, Jeremy, Nunes, Estevao, Perola, Markus, Portoles, Antonio, Rasmin, Menaldi, Raza, Aun, Rees, Helen, Reges, Paula, Rogers, Chris, Salami, Kolawole, Salvadori, Marina, Sauermann, Mamatha, Sinani, Narvina, Sow, Samba, Sterne, Jonathan AC, Stevanovikj, Milena, Tacconelli, Evelina, Tavares Maltez, Fernando Manuel, Teferi, Mekonnen, Tikkinen, Kari, Trelle, Sven, Tsertsvadze, Tengiz, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, Ryan, Michael, Gjermeni, Nevila, Meta, Esmeralda, Aguila, Damian, Alonso, Ignacio, Altamirano, Marcos, Alvarez, María, Alzola, Rodrigo, Arce, Veronica, Arribillaga, Patricia, Avila, Rafael, Balbuena, Juan, Barcelona, Laura, Barletta, José, Benedetti, María, Berdiñas, Verónica, Burgui, Julieta, Caimi, Sabrina, Carrillo, Juan, Carrizo, Juan, Castelli, Juan, Cazaux, Alexis, Cervellino, Flavia, Chalco, Angelo, Chediack, Viviana, Cunto, Eleonora, D'Amico, Nicolàs, de Vedia, Lautaro, Delgado, Carolina, Di Pilla, Debora, Díaz, Miguel, Díaz Aguiar, Pablo, Domínguez, Cecilia, Ellero, Leonor, Farina, Javier, Fernàndez, José, Ferreyra, Roxana, Filippi, María, Fogar, Carolina, Frare, Pablo, Giudiche, Celeste, Golikow, Mariana, Gomez, Maria Georgina, Hermida, Laura, Hurtado, Mariano, Jacobo, Mariela, Jaume, Martin, Laplume, Diego, Lescano, María, Lista, Nicolàs, Loiacono, Flavia, López, Ana Belen, Losso, Marcelo, Luna, Cecilia, Lupo, Sergio, Marianelli, Leonardo, Martin, Anabella, Masciottra, Florencia, Mykietiuk, Analía, Orellano, Lorena, Pachioli, Valeria, Padilla, María José, Pallavicini, Cecilia, Patroso, Jazmin, Perez Blanco, Luz, Presas, Jose Louis, Provenzano, Matias, Lavera, Lorena, Reichert, Viviana, Riveros, Florencia, Rodríguez, Alejandra, Rolon, María José, Salvay, Carolina, Simonetta, María, Sisto, Alicia, Themines, Sandra, Tito, Fernando, Toibaro, Javier, Torales, Graciela, Verón, Luciano, Vizzotti, Carla, Egle, Alexander, Greil, Richard, Joannidis, Michael, Altdorfer, Antoine, Belkhir, Leila, Fraipont, Vincent, Hites, Maya, Arruda, Erico, Breda, Giovanni, Colussi, Arthur, Corradi, Miran, Croda, Julio, Duani, Helena, João, Esaú, Machado, Elizabeth, Mello, Fernanda, Miranda Filho, Demócrito, Monteiro, Poliana, Nunes, Ceuci, Pereira Junior, Luiz Carlos, Pinto, Gustavo, Raboni, Sonia, Ramos, Marcelo, Ruffing, Leonardo, Santos, Valdilea, Souza, Tamara, Medeiros, Melissa, Schwarzbold, Alexandre, Ali, Karim, Azher, Tanweer, Bellemare, David, Binnie, Alexandra, Borgia, Sergio, Cavayas, Yiorgos Alexandros, Chagnon, Nicholas, Cheng, Matthew, Cloutier, Eve, Conly, John, Costiniuk, Cecilia, Daneman, Nick, Douglas, James, Downey, Catarina, Duan, Erick, Durand, Medeline, English, Shane, Farjou, George, Fera, Evadiki, Fontela, Patricia, Fowler, Rob, Fralick, Mike, Gamble, David Gregory, Geagea, Anna, Grant, Jennifer, Harrison, Luke, Havey, Thomas, Hoang, Holly, Kelly, Lauren, Keynan, Yoav, Khwaja, Kosar, Klein, Marina, Kolan, Christophe, Kronfli, Nadine, Lamontagne, Francois, Lee, Nelson, Lee, Todd, Lim, Rachel, Lostun, Alexandra, MacIntyre, Erika, Malhamé, Isabelle, Martin-Carrier, Francois, McGuinty, Marlee, Munan, Matthew, O'Neil, Conar, Ovakim, Daniel, Papenburg, Jesse, Parhar, Ken, Parvathy, SeemaNair, Perez-Patrigeon, Santiago, Rishu, Asgar, Rushton, Moira, Scherr, Kim, Schwartz, Kevin, Semret, Makeda, Silverman, Micahel, Singh, Ameeta, Sligl, Wendy, Smith, Stephanie, Somayaji, Ranjani, Tan, Darrell, Tran, Tuong-Vi, Tremblay, Alain, Tsang, Jennifer, Turgeon, Alexis, Vakil, Erik, Weatherald, Jason, Yansouni, Cedric, Zarychanski, Ryan, Aristizabal, Claudia, Bravo, Juan, Caicedo, Monica, Chacón, Julio, Garzón, Diego, Guevara, Fredy, Lozano-Gonzàlez, Silvia, Macareno, Hugo, Montañez-Ayala, Anita, Oñate, Jose, Rojas-Gambasica, Jose, Rosso, Fernando, Saavedra, Carlos, Valderrama, Sandra, Vàquiro-Herrera, Eliana, Varón-Vega, Fabio, Zuluaga, Ivan, Abdel Baki, Amin, Abdelbary, Akram, Abdel-Razek, Wael, Amin, Wagdi, Asem, Noha, Elassal, Gehan, Elshesheny, Marwa, Fathy, Mohamed, Fathy, Naglaa, Fayed, Notaila, Hammam, Ahmed, Hassany, Sahar, Ibrahim, Hamdy, Kamal, Ehab, Masoud, Hossam, Mohamed, Maryam, Mohamed Gouda, Abdullah, Moustafa, Ehab, Okasha, Shaimaa, Rafik, Ahmed, Said, Ahmed, Sedky, Asmaa, Solyman Kabil, Mohamed, Tarek, Sara, Tharwat, Ahmed, Zaky, Samy, Abegaz, Emawayish Tesema, Bekele, Zelalem Mekonnen, Asfaw, Filmona Mekuria, Tegegne, Netsanet Aragaw, Teklemariam, Miheret Fikre, Nigusse, Frehiwot Tamiru, Achalu, Daniel Legesse, Weldegergs, Shewit Tesfagabr, Huluka, Dawit Kebede, Tereda, Addisu Birhanu, Ala-Kokko, Tero, Delany, Jutta, Ekroos, Heikki, Hankkio, Riina, Haukipää, Mia, Hetemäki, Iivo, Holma, Pia, Holmberg, Ville, Horstia, Saana, Jalkanen, Ville, Jämsänen, Toni, Järventie, Juuso, Järvinen, Petrus, Kalliala, Ilkka, Kauma, Heikki, Kilpeläinen, Tuomas, Kreivi, Hanna-Riikka, Kuitunen, Ilari, Lamminmäki, Satu, Mäkinen, Laura, Mäntylä, Jarkko, Mattila, Tiina, Myllärniemi, Marjukka, Niskanen, Joni, Nykänen, Taina, Nyqvist, Miro, Paajanen, Juuso, Partanen, Terhi, Patovirta, Riitta-Liisa, Paukkeri, Erja-Leena, Puusti, Emmi, Renner, Andreas, Reponen, Emma, Risku, Sari, Rosberg, Tuomas, Rutanen, Jarno, Säilä, Petrus, Salonen, Päivi, Sinisalo, Marjatta, Sivenius, Katariina, Tuominen, Susanna, Aboab, Jerone, Alfaiate, Toni, Andrejak, Claire, Andreu, Pascal, Belhadi, Drifa, Benezit, Francois, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bougon, David, Bouiller, Kevin, Bounes, Fanny, Boyer, Alexandre, Bruel, Cédric, Buffet, Alexandre, Burdet, Charles, Cazanave, Charles, Chabertier, Cyrille, Clere-Jehl, Rapahel, Costagliola, Dominique, Courjon, Johan-Victor, Crockett, Flora, Danion, Francois, Dechanet, Aline, Dellamonica, Jean, Delmas, Christelle, Diallo, Alpha, Djossou, Felix, Dubost, Clement, Dupont, Axelle, Epaulard, Olivier, Faure, Emmmanuel, Faure, Karine, Fayol, Antoine, Figueiredo, Samy, Fougerou, Claire, Gaborit, Benjamin, Gaci, Rostane, Gagneux-Brunon, Amandine, Gallien, Sebastien, Garot, D, Goehringer, Francois, Gruson, Didier, Hinschberger, Olivier, Hulot, Jean-Sebastien, Jaureguiberry, Stephane, Jean-Michel, Vanessa, Kerneis, Solen, Kimmoun, Antoine, Klouche, Kada, Lachatre, Marie, Lacombe, Karine, Laine, Fabrice, Lanoix, Jean Philippe, Laribi, Samira, Launay, Odile, Laviolle, Bruno, Le Moing, Vincent, Le Pavec, Jerome, Lebeaux, David, Leroy, Sylvie, Lescure, Xavier, Livrozet, Marine, Makinson, Alain, Malvy, Denis, Marquette, Charles-Hugo, Martin-Blondel, Guillaume, Mayaux, Julien, Mekontso Dessap, Armand, Mentre, France, Mercier, Noemie, Meziani, Ferhat, Molina, Jean Michel, Mootien, Yoganaden, Mourvillier, Bruno, Navellou, Jean Christoph, Noret, M, Peiffer- Smadja, Nathan, Peytavin, Gilles, Pialoux, Gilles, Pilmis, Benoît, Piroth, Lionel, Poindron, Vincent, Poissy, Julien, Pourcher, Valerie, Quenot, Jean Pierre, Raffi, Francois, Reignier, Jean, Richard, Jean Christoph, Robert, Céline, Saillard, Juliette, Sayre, Naomi, Senneville, Eric, Stefan, Francois, Tellier, Marie Capucine, Terzi, Nicolas, Textoris, Julien, Thiery, Guillame, Timsit, Jean Francois, Tolsma, Violaine, Tubiana, Sarah, Wallet, Florent, Yazdanpanah, Yazdan, Zerbib, Yoann, Aguilar, Carlos, Erazo, Laura, Fiallos, Angel, Figueroa, Rosbinda, Flores, Juan Jose, Melendez, Lesddyy, Moncada, Wendy, Abraham, Ooriapadickal Cherian, Acharya, Chetankumar, Aedula, Vinaya Sekhar, Aggarwal, Richa, Agrawal, Nishant, Agrawal, Umang, Agrawal, Abhishekh, Ahmad, Mohammad, Atal, Shubham, Babu, Avinash, Baidya, Dalim Kumar, Balachandran, Amith, Bangar, Rakhee, Bhadade, Rakesh, Bhandari, Sudhir, Bhapal, Meghavi, Bhardwaj, Pankaj, Bhati, Gaurav, Bhatia, Pradeep, Bhatt, Krishnakant, Bingi, Thrilok Chander, Borse, Rohidas, Buch, Vyom, Chand, Dipti, Chandwani, Ashish, Charan, Jaykaran, Chaudhari, Mayur, Chaudhari, Kirti, Chaudhary, Vipul, Chauhan, Nishant, Chikara, Gaurav, Daswani, Bharti, de Souza, Rosemarie, Desai, Chetna, Divakar, Balusamy, Divhare, Sujeet, Dorairajan, Suresh Kumar, Dutt, Naveen, Ethirajan, Therani Rajan, Gamit, Amit, Gamit, Sweta, Garg, Mahendra, Goenka, Ajay, Goenka, Aniket, Guleria, Randeep, Gupta, Paras, Gupta, Nivedita, Gupta, Madhur, Harde, Minal, Ingle, Vaibhav, Iyer, Shivkumar, Jamalapuram, Vaishnavi, Jayanthi, Rangarajan, Joshi, Rajnish, Kadam, Abhijeet, Kalakuntla, Hemanth, Kalikar, Mrunalini, Kalme, Sayali, Kamble, Suchit, Kant, Ravi, Kantharia, Bansari, Kashikar, Arundhati, Kavishvar, Abhay, Kayina, Choro Athipro, Kerkar, Pranali, Khadanga, Sagar, Khandare, Sagar, Kokate, Pranjali, Komathi, Jayavelu, Krishnan, Vijay, Krishnan, Jayasree, Krishnan, Sumitra, Kulur Mukhyaprana, Sudha, Kumarasamy, N, Mahavar, Sunil, Maitra, Souvik, Majumdar, Falguni, Malhotra, Supriya, Mamulwar, Megha, Malini, Padma, Marwah, Vikas, Maurya, Akhilesh, Mehta, Kedar, Mesipogu, Rajarao, Misra, Shobha, Mitra, Sajal, Mittal, Ankit, Mohan, Bharathi, Momin, Mohmmedirfan, Nag, Vijaya, Nagarajan, Ramakrishnan, Nagmani, Kammili, Narlawar, Uday, Natarajan, Gopalakrishnan, Nischal, Neeraj, Ogale, Dhananjay, Palat, Paltial, Panda, Prasan, Panda, Samiran, Pandya, Amee, Parate, Rohit, Paritekar, Arunita, Patel, Parvati, Patel, Chetna, Patel, Sunaina, Patel, Vitan, Patel, Deep, Patel, Harshad, Patil, Girish, Peter, Deepu, Prasad, Durga, Purohit, Vimlesh, Rabindrarajan, Ebenezer, Ranganathan, Lakshmiarasimhan, Rao, Tushara, Rao, Chakradhara, Rathod, Chirag, Raval, Devang, Ray, Avik, Reddy, Kamini, Rege, Sujata, Revathi, Ayyasamy, Roy, Dhara, Saigal, Saurabh, Sane, Suvarna, Sangale, Shashi, Seetharaman, Krishnamoorthy, Selvamuthu, Poongulali, Seshaiah, Kurada Venkata, Shadrach, Benhur, Shah, Jignesh, Shah, Sonal, Sharma, Swati, Sharma, Raman, Sharma, Shrikant, Singh, Krishna, Singh, Anil, Singh, Arjeet, Singhai, Abhishek, Soneja, Manish, Soni, Kapil Dev, Subhan, Thasneem banu, Subramaniam, Sudharshini, Sudarsanam, Thambu David, Sudarsi, Ravindra Kumar, Suleman, Dawood, Suthar, Nilay, Talati, Shriraj, Tambe, Murlidhar, Tejomurtula, Tilak, Tirupakuzhi Vijayaraghavan, Bharatkumar, Trikha, Anjan, Trivedi, Aarti, Udwadia, Zarir, Upadhyay, Kamlesh, Vasava, Ashwin, Vasudevan, Damodaran, Velayudham, Rajendran, Venkatasubramanian, Ramasubramanian, Verma, Mamta, Waghmare, Rakesh, Waikar, Anushka, Wig, Naveet, Afrilia, Annisa Rizky, Amin, Muhammad, Arlinda, Dona, Avrina, Rossa, Bang, Lois, Djaharuddin, Irawaty, Djojo, Aryan, Driyah, Sri Laning, Erastuti, Mila, Fajarwati, Tetra, Harsini, Harsini, Hartantri, Yovita, Herman, Deddy, Isbaniah, Fathiyah, Karyana, Muhammad, Kusuma, Indra, Mahmudji, Harli Amir, Medison, Irvan, Nugroho, Agung, Nurhayati, Nurhayati, Opitasari, Cicih, Pitoyo, Ceva Wicaksono, Pradana, Antonius Arditya, Raharjo, Sofyan Budi, Rahmaini, Ade, Risniati, Yenni, Riyanto, Bambang Sigit, Sajinadiyasa, I Gede Ketut, Sari, Flora Eka, Sitompul, Pompini Agustina, Soedarsono, Soedarsono, Somia, I Ketut Agus, Sugiri, Yani Jane, Sugiyono, Retna Indah, Susanto, Nugroho Harry, Syarif, Armaji Kamaludi, Yulianto, Aris, Afsharian, Mandana, Akhavi Mirab, Atefehsadat, Amini, Fatemeh, Amini, Mahnaz, Ansarin, Khalil, Baba Mahmoodi, Farhang, Baghaei, Parvaneh, Barazandeh, Fateme, Bayani, Masomeh, Dastan, Farzaneh, Ebrahimpour, Soheil, Eghtesad, Sareh, Fallahi, Mohammad Javad, Fallahpoor Golmaee, Fatemeh, Foroghi Ghomi, Seyed Yaser, Ghadir, Mohammad Reza, Gheitani, Mina, Ghiasvand, Fereshteh, Hafizi Lotfabadi, Saied, Hakamifard, Atousa, Hashemi Madani, Shima Sadat, Hormati, Ahmad, Hosseini, Hamed, Janbakhsh, Alireza, Javanian, Mostafa, Joukar, Farahnaz, Kamali, Alireza, Karampour, Amin, Khajavirad, Nasim, Khodabakhshi, Behnaz, Khodadadi, Javad, Khodashahi, Rozita, Kiani Majd, Somaieh, Mahfoozi, Lida, Mahmoodiyeh, Behnam, Mansour-Ghanaei, Fariborz, Mansouri, Feizollah, Mesgarpour, Bita, Mesri, Mehdi, Mikaeili, Haleh, Miladi, Ronak, Moghadami, Mohsen, Mohamadi, Payam, Mohraz, Minoo, Mohseni Afshar, Zeinab, Moogahi, Sasan, Mousavi Anari, Seyed Alireza, Mozaffar, Seyyed Hassan, Mozdourian, Mahnaz, Najafipour, Reza, Najari, Hamidreza, Nazemiyeh, Masoud, Norouzi, Alireza, Pourkazemi, Aydin, Poustchi, Hossein, Saberhosseini, Seyedeh Naeimeh, Saberi, Marzieh, Saber-Moghaddam, Niloufar, Sadeghi, Anahita, Sadeghi Haddad Zavareh, Mahmoud, Sahraian, Mohammad Ali, Salahi, Mehrdad, Salehi, Mohammad Reza, Sarmadian, Hossein, Sayad, Babak, Shirani, Kiana, Shirvani, Maria, Shojaei, Daryanaz, Shokri, Mehran, Siami, Zeinab, Sima, Ali Reza, Soleimani, Alireza, Soltanmohammad, Saedeh, Tabarsi, Payam, Taghizadieh, Ali, Tavassoli, Samaneh, Varnasseri, Mehran, Vaziri, Siavash, Yadyad, Mohammad Jaafar, Yaghoubi, Shoeleh, Yazdanpanah, Yalda, Yousefi, Farid, Zamanian, Mohammad Hossein, Zand, Farid, Zare Hoseinzade, Elham, Bergin, Colm, Cotter, Aoife, de Barra, Eoghan, Jackson, Arthur, Laffey, John, McCarthy, Cormac, Muldoon, Eavan, Sadlier, Corinna, Maguire, Teresa, Angheben, Andrea, Bai, Francesca, Bandera, Alessandra, Barchiesi, Francesco, Bassetti, Matteo, Bisi, Luca, Bonfanti, Paolo, Calò, Federica, Campoli, Caterina, Canovari, Benedetta, Capetti, Amedeo, Castelli, Francesco, Cauda, Roberto, Cingolani, Antonella, Cocco, Nicolò, Coppola, Nicola, Corcione, Silvia, Cremonini, Eleonora, d'Arminio Monforte, Antonella, de Gaetano Donati, Katleen, De Nardo, Pasquale, De Rosa, Francesco Giuseppe, Degioanni, Maria, Della Siega, Paola, Di Bella, Stefano, Drera, Bruno, Focà, Emanuele, Fornabaio, Chiara, Galli, Massimo, Giacomazzi, Donatella, Gori, Andrea, Gustinetti, Giulia, Iannuzzi, Francesca, Kertusha, Blerta, Lamonica, Silvia, Lichtner, Miriam, Lupia, Tommaso, Luzzati, Roberto, Macera, Margherita, Menatti, Elisabetta, Merelli, Maria, Merlini, Esther, Monari, Caterina, Pan, Angelo, Pecori, Davide, Pezzani, Diletta, Riccardi, Niccolò, Rodari, Paola, Roldan, Eugenia, Rovere, Pierangelo, Rusconi, Stefano, Scabini, Silvia, Tascini, Carlo, Viale, Pierluigi, Vincenzi, Marcello, Zuccalà, Paola, Zucchi, Patrizia, Al-Roomi, Moudhi, Al-Sabah, Salman, Schrapp, Kelly, Hassoun, Mahmoud, Matar, Madonna, Dbouni, Oussaima, Yared, Nadine, Saliba, Michele, Farra, Anna, Riachi, Moussa, Zablockiene, Birute, Reuter, Jean, Staub, Therese, Ab Wahab, Suhaila, Chew, Chun Keat, Chua, Hock Hin, Goh, Pik Pin, Lee, Heng Gee, Leong, Chee Loon, Low, Lee Lee, Mak, Wen Yao, Mohamed Gani, Yasmin, Muhamad, Dzawani, Zaidan, Nor Zaila, Ducker, Camilla, Demiri, Ilir, Aballi, Saad, Berg, Åse, Blomberg, Bjørn, Dalgard, Olav, Dyrhol-Riise, Anne Ma, Eiken, Ragnhild, Ernst, Gernot, Hannula, Ranula, Haugli, Metter, Heggelund, Lars, Hoel, Hedda, Hoff, Dag Arne Lihaug, Holten, Aleksander Rygh, Johannessen, Asgeir, Kåsine, Trine, Kildal, Anders Benjamin, Kittang, Bård Reikvam, Nezvalova-Henriksen, Katerina, Olsen, Inge Christoffer, Olsen, Roy Bjørkolt, Skei, Nina Vibeche, Skudal, Hilde, Tholin, Birgitte, Thoresen, Lars, Trøseid, Marius, Tveita, Anders, Vinge, Leif, Ystrøm, Carl Magnus, Al Jahdhami, Issa, AlNaamani, Khalid, Al Balushi, Zakariya, Pandak, Nenad, Abbas, Salma, Akhtar, Nasim, Azam, Sumeyya, Begum, Dilshad, Hassan, Sadia, Herekar, Fivzia, Khan, Shahzaib, Khan, Ejaz Ahmed, Mahmood, Syed Faisal, Nasir, Nosheen, Rahim, Anum, Sarfaraz, Samreen, Shaikh, Qurat-ul-Ain, Sultan, Faisal, Walayat, Usman, Agurto-Lescano, Erika Cecilia, Alcantara-Díaz, Andrés Martín, Alva-Correa, Ana María, Alvarado-Moreno, José Gustavo, Ángeles-Padilla, Bethsabé, Arbañil-Huamàn, Hugo César, Ávila-Reyes, Pool Christopher, Azañero-Haro, Johan Alexander, Barreto-Rocchetti, Luis Guillermo, Benitez-Peche, Jorge Marko A., Bernal-Màlaga, Karla Hortencia, Cabrera-Portillo, Liliana Norma, Carazas-Chavarry, Reynaldo Javier, Càrcamo, Paloma Mariana, Casimiro-Porras, Indira Catalina, Castillo-Espinoza, Jhuliana, Chacaltana-Huarcaya, Jesús Norberto, Cornejo-Valdivia, Carla Raquel, Cruz-Chereque, Augusto, Del-Aguila-Torres, Keith Cayetano Marcelino, Díaz-Chipana, Erika, Flores-Valdez, Neil, Franco-Vàsquez, Rosanna Andrea, Gallegos-López, Roxana Consuelo, Gastiaburú-Rodriguez, Dauma Yesenia, Gianella-Malca, Gonzalo Ernesto, Gomero-Lopez, Andrés Alonso, Hercilla-Vàsquez, Luis Enrique, Hueda-Zavaleta, Miguel Ángel, Ibarcena-Llerena, Claudia Vanessa, Iberico-Barrera, Carlos Alberto, Inquilla-Castillo, Miguel Angel, Juàrez-Eyzaguirre, Jesus Alberto, Laca-Barrera, Manuel, León-Jiménez, Franco, Luna-Wilson, Carla Vanessa, Màlaga, German, Marin, Ricardo, Mejía-Cordero, Fernando, Mendoza-Laredo, Juan Arturo, Meregildo-Rodríguez, Edinson Dante, Miranda-Manrique, Gonzalo Francisco, Olivera-Chaupis, Marco, Ortega-Monasterios, Fatima Josefina, Otazú-Ybàñez, Jimmy Pedro, Paredes-Moreno, María Angélica, Peña-Mayorga, Claudia Ximena, Peña-Vàsquez, Olivia del Carmen, Peña-Villalobos, Alejandro, Ponce, Oscar J, Ponte-Fernandez, Katherin Estefania, Pro, Jose, Quispe-Nolazco, César Miguel, Ramos-Samanez, Manuel Efrain, Rojas-Murrugarra, Kory Mirtha, Samanez-Pérez, Jorge Mauro, Sànchez-Carrillo, Halbert Chrostian, Sànchez-Garavito, Epifanio, Sànchez-Sevillano, Ricardo Manuel, Sandoval-Manrique, Hernan, Santos-Revilla, Gabriela, Silva-Ramos, Julio Antonio, Solano-Ico, Manuel Alberto, Soto, Alonso, Sotomayor-Woolcott, Giannilu Michelle, Tapia-Orihuela, Ruben Kevin Arnold, Terrazas-Obregón, Carmen Sara, Terrones-Levano, Victor Francisco, Ticona-Huaroto, Cesar Eduardo, Torres-Ninapayta, Walter, Torres-Ruiz, Oscar Martin, Ugarte-Mercado, Dario, Vargas-Anahua, Orlando José, Vàsquez-Becerra, Ruben Dario, Vàsquez-Cerro, José Gabriel, Villegas-Chiroque, Miguel, Williams, Anna Larson, Yauri-Lazo, Randi Mauricio, Abad, Cybele Lara, Andales-Bacolcol, Silverose Ann, Arcegono, Marlon, Arches, Jamie, Astudillo, Mary Grace, Aventura, Emily, Awing, Arlyn, Bala, Mishelle Vonnabie, Bello, Jia An, Blanco, Peter, Benedicto, Jubert, Buno, Susana, Cabrera, Justine, Cajulao, Thea Pamela, Caoili, Janice, Casiple-Amsua, Lina, Catambing, Victor, Chin, Inofel, Chua, Ma. Bernadette, Chua, Mitzi Marie, Climacosa, Fresthel Monica, David-Wang, Aileen, De los Reyes, Virginia, Europa, Gilly May, Fernandez, Lenora, Francisco, Jorge, Garcia, Gerard, Garcia, Jemelyn, Gler, Maria Tarcela, Isidro, Marie Grace Dawn, Javier, Rozelle Jade, Kwek, Marion, Lansang, Mary Ann, Lee, Aileen, Li, Kingbherly, Llanes, Mark Ramon Victor, Llorin, Ryan, Macadato, Omar Khayyam, Malundo, Anna Flor, Mercado, Maria Elizabeth, Mujeres, Mercedes, Nepomuceno, Marisse, Ngo-Sanchez, Katha, Orden, Mary Claire, Pablo-Villamor, Maria Philina, Paez, Ruel Dionisio, Palmes, Patricio, Panaligan, Marion, Quinivista-Yoon, Jenny Mae, Ramos, Mary Shiela Ariola, Ramos -Penalosa, Christine, Reyes, Sheila Marie, Roa, Kathryn, Roman, Arthur Dessi, Rosario, Minette Claire, Roxas, Evalyn, Santos, Lourdes Ella Gonzales, Soldevilla, Helmar, Solante, Rontgene, Suaco, Jane, Tagarda, Daisy, Tang, Issa Rufina, Te, Bob, Teo, Dennis, Tibayan, Christopher John, Villalobos, Ralph Elvi, Ymbong, Duane Richard, Zabat, Gelza Mae, Batkova, Stepanka, Cardoso, Orlando, Garrote, Ana-Raquel, Lino, Sara, Manata, Maria-José, Pinheiro, Helder, Póvoas, Diana, Ramirez, Freddy, Seixas, Diana, Naji, Assem, Al Gethamy, M Al, AL-Mulaify, Mohammed Sami, Al Maghraby, Reem, Alrajhi, A, Al Sharidi, Aynaa, Alotaibi, Naif, AlShaharani, F, Barry, Mazin, Ghonem, Leen, Khalel, Anas, Kharaba, Ayman Mohammed, Alabdan, Lulwah, AlAbdullah, Mohammed Sharaf, Al Shabib, Abdullah, Bengu, Simangele, Bennet, Jacklyn, Dubula, Thozama, Howell, Pauline, Janse van Vuuren, Cloete, Kalla, Ismail, Lifson, Aimee, Maasdorp, Shaun, Magua, Nombulelo, Maluleke, Vongani, Mbhele, Nokuphiwa, Mdladla, Nathi, Mendelson, Mark, Menezes, Colin, Mwelase, Thando, Nchabeleng, Maphoshane, Palanee-Phillips, Thesla, Parker, Victoria, Rassool, Mohammed, Reeder, Paul, Sossen, Bianca, Steyn, Dewald, Tsitsi, Merika, van Blydenstein, Sarah Alex, Venter, Michelle, Van Vuuren, Janse, Venturas, Jacquie, Abad Pérez, Daniel, Abenza, Maria José, Alarcón-Payer, Carolina, Armero Garrigos, Eva, Arribas, Jose Ramon, Ascaso, Ana, Berenguer, Juan, Cabello-Clotet, Noemí, Chamorro Tojeiro, Sandra, Cuenca-Acevedo, Rafael, de la Calle, Fernando, Del Toro, Maria Dolores, Díaz Pollàn, Beatriz, Diez, Cristina, Esquillor-Rodrigo, María José, Estrada, Vicente, Fanciulli, Chiara, Fanjul, Francisco, Fernàndez de Orueta, Lucía, Ferre, Adrian, Ferreira Pasos, Eva Maria, Gainzarain-Arana, Juan-Carlos, Garcia, Felipe, García Deltoro, Miguel, Goikoetxea Agirre, Ane Josune, Gómez Barquero, Julia, Gomez-Huelgas, Ricardo, Gonzàlez Moraleja, Julio, Guijarro, Carlos, Gutierrez, Felix, Guzmàn, Jesús, Ibarguren, Maialen, Iribarren, Jose Antonio, Jerusalem, Koen, Juan Arribas, Arturo, Lalueza, A, Leone, Antonio, Lopez Azkarreta, Iñigo, Lozano-Martin, Daniel, Lucendo, Alfredo J, Luengo López, Mariella, Martín Oterino, JA, Masa, JF, Merino, Esperanza, Monge-Maillo, Begoña, Moran-Rodríguez, Miguel-Angel, Muñez Rubio, Elena, Muñoz Sanchez, Josefa, Nuñez Orantos, Maria Jose, Nuño, Enrique, Ortiz-De-Zarate-Ibarra, Zuriñe, Pagàn-Muñoz, Bàrbara, Paño-Pardo, José Ramón, Peñaranda, Maria, Pérez Chica, Gerardo, Pérez Fernàndez, AM, Pérez-López, Carmen, Polo San Ricardo, Victor, Portu-Zapirain, Joseba, Puchades, Francesco, Rivas Paterna, Ana Belen, Rodríguez Vidigal, Francisco F, Rodríguez-Baño, Jesus, Ruiz-Seco, Pilar, Ryan, Pablo, Saez-De-Adana, Ester, Salas, Rosario, Salavert Lletí, Miguel, Sandoval, Raquel, Toyas-Miazza, Carla, Valencia, Jorge, Vargas, Emilio, Velasco, Maria, Von Wichmann, Miguel Angel, Bosshard, Andreas, Calmy, Alexandra, Castro, Tiago, Cavassini, Matthias, Clerc, Olivier, Conen, Anna, Desbaillets, Nicolas, Desgranges, Florian, Duss, Francois, Emonet, Stephane, Erard, Veronique, Eyer, Myriam, Fayet-Mello, Aurélie, Flammer, Yvonne, Friedl, Andrée, Fulchini, Rosamaria, Furrer, Hansjakob, Garin, Nicolas, Gastberger, Salome, Greiner, Michael, Haefliger, David, Haubitz, Sebastian, Hoffmann, Matthias, Isenring, Egon, Jakopp, Barbara, Lampert, Markus, Marinosci, Annalisa, Martin, Yvonne, Petignat, Pierre-Auguste, Piso, Rein Jan, Prendki, Virginie, Rutishauser, Jonas, Schaefer, Elisabeth, Schmiedel, Yvonne, Schwery, Stefan, Stavropoulou, Elisavet, Stoeckle, Marcel, Suttels, Veronique, Thurnher, Maria Christine, van den Bogaart, Lorena, West, Emily, Wiegand, Jan, and Wiggli, Benedikt
- Published
- 2022
- Full Text
- View/download PDF
13. Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial
- Author
-
Self, Wesley H., Sandkovsky, Uriel, Reilly, Cavan S., Vock, David M., Gottlieb, Robert L., Mack, Michael, Golden, Kevin, Dishner, Emma, Vekstein, Andrew, Ko, Emily R., Der, Tatyana, Franzone, John, Almasri, Eyad, Fayed, Mohamed, Filbin, Michael R., Hibbert, Kathryn A., Rice, Todd W., Casey, Jonathan D., Hayanga, J. Awori, Badhwar, Vinay, Leshnower, Bradley G., Sharifpour, Milad, Knowlton, Kirk U., Peltan, Ithan D., Bakowska, Elizieta, Kowalska, Justyna, Bowdish, Michael E., Sturek, Jeffrey M., Rogers, Angela J., Files, D. Clark, Mosier, Jarrod M., Gong, Michelle N., Douin, David J., Hite, R. Duncan, Trautner, Barbara W., Jain, Mamta K., Gardner, Edward M., Khan, Akram, Jensen, Jens-Ulrik, Matthay, Michael A., Ginde, Adit A., Brown, Samuel M., Higgs, Elizabeth S., Pett, Sarah, Weintrob, Amy C., Chang, Christina C., Murrary, Daniel D., Günthard, Huldrych F., Moquete, Ellen, Grandits, Greg, Engen, Nicole, Grund, Birgit, Sharma, Shweta, Cao, Huyen, Gupta, Rajesh, Osei, Suzette, Margolis, David, Zhu, Qing, Polizzotto, Mark N., Babiker, Abdel G., Davey, Victoria J., Kan, Virginia, Thompson, B. Taylor, Gelijns, Annetine C., Neaton, James D., Lane, H. Clifford, Jundgren, Jens D., Tierney, John, Barrett, Kevin, Herpin, Betsey R., Smolskis, Mary C., Voge, Susan E., McNay, Laura A., Cahill, Kelly, Crew, Page, Kirchoff, Matthew, Sardana, Ratna, Raim, Sharon Segal, Chiu, Joseph, Hensley, Lisa, Lorenzo, Josua, Mock, Rebecca, Shaw-Saliba, Katy, Zuckerman, Judith, Adam, Stacey J., Currier, Judy, Read, Sarah, Hughes, Eric, Amos, Laura, Carlsen, Amy, Carter, Anita, Davis, Bionca, Denning, Eileen, DuChene, Alain, Harrison, Merrie, Kaiser, Payton, Koopmeiners, Joseph, Meger, Sue, Murray, Thomas, Quan, Kien, Quan, Siu Fun, Thompson, Greg, Walski, Jamie, Wentworth, Deborah, Moskowitz, Alan J., Bagiella, Emilia, O'Sullivan, Karen, Marks, Mary E., Accardi, Evan, Kinzel, Emily, Bedoya, Gabriela, Gupta, Lopa, Overbey, Jessica R., Padillia, Maria L., Santos, Milerva, Gillinov, Marc A., Miller, Marissa A., Taddei-Peters, Wendy C., Fenton, Kathleen, Berhe, Mezgebe, Haley, Clinton, Bettacchi, Christopher, Duhaime, Erin, Ryan, Madison, Burris, Sarah, Jones, Felecia, Villa, Samantha, Want, Samantha, Robert, Raven, Coleman, Tanquinisha, Clariday, Laura, Baker, Rebecca, Hurutado-Rodriguez, Marian, Iram, Nazia, Fresnedo, Michelle, Davis, Allyson, Leonard, Kiara, Ramierez, Noelia, Thammavong, Jon, Duque, Krizia, Turner, Emma, Fisher, Tammy, Robinson, Dianna, Ransom, Desirae, Lusk, Erica, Killian, Aaron, Palacious, Adriana, Solis, Edilia, Jerrow, Janet, Watts, Matthew, Whitacre, Heather, Cothran, Elizabeth, Smith, Peter K., Barkauskas, Christina E., Dreyer, Grace R., Witte, Marie, Mosaly, Nilima, Mourad, Ahmad, Holland, Thomas L., Lane, Kathleen, Bouffler, Andrew, McGowan, Lauren M., Motta, Marry, Tipton, Gregory, Stallings, Ben, Stout, Gennifer, McLendon-Arvik, Beth, Hollister, Beth A., Giangiacomo, Dana M., Sharma, Sunil, Pappers, Brian, McCarthy, Paul, Krupica, Troy, Sarwari, Arif, Reece, Rebecca, Fornaresio, Lisa, Glaze, Chad, Evans, Raquel, Preamble, Katarina, Sutton, Lisa Giblin, Buterbaugh, Sabrina, Bartolo, Elizabeth Berry, Williams, Roger, Bunner, Robin, Bender, William, Miller, Jeffrey, Baio, Kim T., McBride, Mary K., Fielding, Michele, Mathewson, Sonya, Porte, Kristina, Maton, Missy, Ponder, Chari, Haley, Elizabeth, Spainhour, Christine, Rogers, Susan, Tyler, Derrick, Wald-Dickler, Noah, Hutcheon, Douglass, Towfighi, Amytis, Lee, May M., Lewis, Meghan R., Spellberg, Brad, Sher, Linda, Sharma, Aniket, Olds, Anna P., Justino, Chris, Lozano, Edward, Romero, Chris, Leong, Janet, Rodina, Valentina, Possemato, Tammie, Escobar, Jose, Chiu, Charlene, Weissman, Kevin, Barros, Andrew, Enfield, Kyle B., Kadl, Alexandra, Green, China J., Simon, Rachel M., Fox, Ashley, Thornton, Kara, Parrino, Patrick E., Spindel, Stephen, Bansal, Aditya, Baumgarten, Katherine, Hand, Jonathan, Vonderhaar, Derek, Nossaman, Bobby, Laudun, Sylvia, Ames, DeAnna, Broussard, Shane, Hernandez, Nilmo, Isaac, Geralyn, Dinh, Huan, Zheng, Yiling, Tran, Sonny, McDaniel, Hunter, Crovetto, Nicolle, Miller, Leslie, Schelle, Beth, McLean, Sherry, Rothbaum, Howard R., Alvarez, Michael S., Kalan, Shivam P., Germann, Heather H., Hendershot, Jennifer, Maroney, Karen, Herring, Karen, Cook, Sharri, Paul, Pam, Madathil, Ronson J., Rabin, Joseph, Levine, Andrea, Saharia, Kapil, Tabatabai, Ali, Lau, Christine, Gammie, James S., Peguero, Maya-Loren, McKernan, Kimberley, Audette, Matthew, Fleischmann, Emily, Akbari, Freshta, Lee, Maia, Lee, Myounghee, Chi, Andrew, Salehi, Hanna, Pariser, Alan, Nguyen, Phuong Tran, Moore, Jessica, Gee, Adrienne, Vincent, Shelika, Zuckerman, Richard A., Iribarne, Alexander, Metzler, Sara, Shipman, Samantha, Caccia, Taylor, Johnson, Haley, Newton, Crystallee, Parr, Doug, Rodriguez, Vicente, Bokhart, Gordon, Eichman, Sharon M., North, Crystal, Oldmixon, Cathryn, Ringwood, Nancy, Fitzgerald, Laura, Morin, Haley D., Muzikansky, Ariela, Morse, Richard, Brower, Roy G., Reineck, Lora A., Aggarwal, Neil R., Bienstock, Karen, Hou, Peter, Steingrub, Jay, Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Leslie, Thornton-Thompson, Sherell, Talmor, Daniel, Shapiro, Nathan, Banner-Goodspeed, Valerie, Boyle, Katherine L., Hayes, Sharon, Jones, Alan E., Galbraith, James, Nandi, Utsav, Peacock, Rebekah K., Parry, Blair Alden, Margolin, Justin D., Brait, Kelsey, Beakes, Caroline, Kangelaris, Kirsten N., Yee, Kimberly J., Ashktorab, Kimia, Jauregui, Alejandra E., Zhuo, Hanjing, Hendey, Gregory, Hubel, Kinsley A., Hughes, Alyssa R., Garcia, Rebekah L., Wilson, Jennifer G., Vojnik, Rosemary, Roque, Jonasel, Perez, Cynthia, Lim, George W., Chang, Steven Y., Beutler, Rebecca, Agarwal, Trisha, Vargas, Julia, Moss, Marc, Baduashvili, Amiran, Chauhan, Lakshmi, Finck, Lani L., Howell, Michelle, Hyzy, Robert C., Park, Pauline K., Nelson, Kristine, McSparron, Jake I., Co, Ivan N., Wang, Bonnie R., Jia, Shijing, Sullins, Barbara, Hanna, Sinan, Olbrich, Norman, Richardson, Lynne D., Nair, Rahul, Offor, Obiageli, Lopez, Brenda, Amosu, Omowunmi, Tzehaie, Hiwet, Terndrup, Thomas E., Wiedemann, Herbert P., Duggal, Abhijit, Thiruchelvam, Nirosshan, Ashok, Kiran, King, Alexander H., Mehkri, Omar, Hudock, Kristin, Kiran, Simra, More, Harshada, Roads, Tammy, Martinkovic, Jamie, Kennedy, Sarah, Robinson, Bryce H., Hough, Catherine L., Krol, Olivia F., Kinjal, Mistry, Mills, Emmanuel, McDougal, Madeline, Deshmukh, Rupali, Chen, Peter, Torbati, Sam S., Matusov, Yuri, Choe, June, Hindoyan, Niree A., Jackman, Susan E., Bayoumi, Emad, Wynter, Timothy, Caudill, Antonina, Pascual, Ethan, Clapham, Gregg J., Herrera, Lisa, Ojukwu, Cristabelle, Mehdikhani, Shaunt, O'Mahony, D. Shane, Nyatsatsang, Sonam T., Wilson, David M., Wallick, Julie A., Miller, Chadwick, Gibbs, Keven W., Flores, Lori S., LaRose, Mary E., Landreth, Leigha D., Morris, Peter E., Sturgill, Jamie L., Cassity, Evan P., Dhar, Sanjay, Montgomery-Yates, Ashley A., Pasha, Sara N., Mayer, Kirby P., Bissel, Brittany, Bledsoe, Joseph, Brown, Samuel, Lanspa, Michael, Leither, Lindsey, Armbruster, Brent P., Montgomery, Quinn, Applegate, Darrin, Kumar, Naresh, Fergus, Melissa, Serezlic, Erna, Imel, Karah, Palmer, Ghazal, Webb, Brandon, Aston, Valerie T., Johnson, Jakea, Gray, Christopher, Hays, Margaret, Roth, Megan, Sánchez, Adriana, Popielski, Laura, Rivasplata, Heather, Turner, Melissa, Vjecha, Michael, Petersen, Tianna, Kamel, Dena, Hansen, Laura, Lucas, Claudia Sanchez, DellaValle, Natalie, Gonzales, Sonia, Scott, James, Wyles, David, Douglas, Ivor, Haukoos, Jason, Kamis, Kevin, Robinson, Caitlin, Baker, Jason V., Frosch, Anne, Goldsmith, Rachael, Jibrell, Hodan, Lo, Melanie, Klaphake, Jonathan, Mackedanz, Shari, Ngo, Linh, Garcia-Myers, Kelly, Markowitz, Norman, Pastor, Erika, Ramesh, Mayur, Brar, Indira, Rivers, Emanuel, Kumar, Princy, Menna, Maximiliano, Biswas, Kousick, Harrington, Cristin, Delp, Alex, Pandit, Lavannya, Hines-Munson, Casey, Van, John, Dillon, Laura, Want, Yiqun, Lichtenberger, Paola, Baracco, Gio, Ramos, Carol, Bjork, Lauren, Sueiro, Melyssa, Tien, Phyllis, Freasier, Heather, Buck, Theresa, Nekach, Hafida, Nagy-Agren, Stephanie, Vasudeva, Shikha, Ochalek, Tracy, Roller, Brentin, Nguyen, Chinh, Mikail, Amani, Raben, Dorthe, Jensen, Tomas O., Aagaard, Bitten, Nielsen, Charlotte B., Krapp, Katharina, Nykjær, Bente Rosdahl, Kanne, Katja Lisa, Grevsen, Anne Louise, Joensen, Zillah Maria, Bruun, Tina, Bojesen, Ane, Woldbye, Frederik, Normand, Nick E., Esmann, Frederik V.L., Clausen, Clara Lundetoft, Hovmand, Nichlas, Pedersen, Karen Brorup, Thorlacius-Ussing, Louise, Tinggaard, Michaela, Høgsberg, Dorthe S., Rastoder, Ema, Kamstrup, Thobias, Bergsøe, Christina Marisa, Østergaard, Lars, Stærke, Nina Breinholt, Johansen, Isik S., Knudtzen, Fredrikke C., Larsen, Lykke, Hertz, Mathias A., Fabricius, Thilde, Helleberg, Marie, Gerstoft, Jan, Jensen, Tomas Østergaard, Lindegaard, Birgitte, Pedersen, Thomas Ingemann, Røge, Birgit Thorup, Løfberg, Sandra Valborg, Hansen, Thomas Michael, Nielsen, Ariella Denize, von Huth, Sebastian Leicht, Nielsen, Henrik, Thisted, Rikke Krog, Podlekareva, Daria, Johnsen, Stine, Andreassen, Helle Frost, Pedersen, Lars, Lindnér, Cecilia Ebba Clara Ellinor, Wiese, Lothar, Knudsen, Lene Surland, Nytofte, Nikolaj Julian Skrøder, Havmøller, Signe Ravn, Paredes, Roger, Exposito, Maria, Fernández-Cruz, Eduardo, Muñoz, José, Arribas, Jose R., Estrada, Vicente, Horcajada, Juan P., Burgos, Joaquin, Morales-Rull, Jose Luis, Braun, Dominique L., West, Emily, M'Rabeth-Bensalah, Khadija, Eichinger, Mareile L., Grüttner-Durmaz, Manuela, Grube, Christina, Zink, Veronika, Horban, Andrzej, Bednarska, Agnieszka, Jurek, Natalia, Fätkenheuer, Gerd, Malinm, Jakob J., Matthews, Gail, Kelleher, Anthony, Cabrera, Gesalit, Carey, Catherine, Hough, Sally, Virachit, Sophie, Zhong, Amy, Young, Barnaby E., Chia, Po Ying, Lee, Tau Hong, Lin, Ray J., Lye, David, Ong, Sean, Puah, Ser Hon, Yeo, Tsin Wen, Diong, Shiau Hui, Ongko, Juwinda, Hudson, Fleur, Parmar, Mahesh KB, Goodman, Anna, Badrock, Jonathan, Gregory, Adam, Harris, Nicola, Touloumi, Giota, Pantaz, Nikos, Gioukari, Vicky, Lutaakome, Joseph, Kityo, Cissy M., Mugerwa, Henry, Kiweewa, Francis, Osinusi, Anu, Tipple, Craig, Willis, Angela, Peppercorn, Amanda, Watson, Helen, Alexander, Elizabeth, Mogalian, Erik, Lin, Leo, Ding, Xiao, Yan, Li, Girardet, Jean-Luc, Ma, Ji, Hong, Zhi, Adams, Amy, Albert, Sara, Balde, Abby, Baracz, Michelle, Baseler, Beth, Becker, Nancy, Bielica, Mona, Billouin-Frazier, Shere, Cash, Jennifer, Choudhary, Jay, Dolney, Suzanne, Dixon, Mary, Eyler, Carolyn, Frye, Leanna, Galcik, Michael, Gertz, Jensen, Giebeig, Lisa, Gulati, Neelam, Hankinson, Liz, Hissey, Debbie, Hogarty, Debi, Hohn, Matt, Holley, H Preston, Hoopengardner, Lisa, Huber, Lynda, Jankelevich, Shirley, Krauss, Gary, Lake, Eileen, Linton, Jessica, MacDonald, Leah, Manandhar, Meryan, Spinelli-Nadzam, Mary, Oluremi, Charles, Proffitt, Calvin, Rudzinski, Erin, Sandrus, Jen, Schaffhauser, Marylu, Schechner, Adam, Suders, Connie, Gerry, Norman P., Smith, Kenneth, Solomon, Courtney, Kubernac, Amanda, Rashid, Marium, Patel, Bhakti, Kubernac, Robert, Murphy, Joseph, Hoover, Marie L., Brown, Craig, DuChateau, Nadine, Flosi, Adam, Johnson, Les, Treagus, Amy, and Wenner, Christine
- Published
- 2022
- Full Text
- View/download PDF
14. A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19.
- Author
-
Landete, Pedro, Caliman-Sturdza, Olga-Adriana, Lopez-Martin, Jose A, Preotescu, Liliana, Luca, Mihaela-Catalina, Kotanidou, Anastasia, Villares, Paula, Iglesias, Shirley-Patricia, Guisado-Vasco, Pablo, Saiz-Lou, Elena-Maria, Farinas-Alvarez, Maria del Carmen, Lucas, Esperanza Merino de, Perez-Alba, Eduardo, Cisneros, Jose-Miguel, Estrada, Vicente, Hidalgo-Tenorio, Carmen, Poulakou, Garyfallia, Torralba, Miguel, Fortun, Jesus, and Garcia-Ocana, Paula
- Subjects
COMBINATION drug therapy ,PATIENT safety ,RESEARCH funding ,STATISTICAL sampling ,HOSPITAL care ,OXYGEN therapy ,TERMINATION of treatment ,RANDOMIZED controlled trials ,DESCRIPTIVE statistics ,INVERTEBRATES ,PEPTIDES ,ANTIVIRAL agents ,DRUG efficacy ,RESEARCH ,CONFIDENCE intervals ,COVID-19 ,MARINE animals ,DEXAMETHASONE ,EVALUATION ,ADULTS - Abstract
Background Plitidepsin has shown potent preclinical activity against severe acute respiratory syndrome coronavirus 2 and was generally well tolerated in a phase I trial of hospitalized patients with coronavirus disease 2019 (COVID-19). NEPTUNO, a phase III, multicenter, randomized, controlled trial, was designed to evaluate the efficacy and safety of plitidepsin in the management of moderate COVID-19 in hospitalized adult patients. Methods Included patients had documented severe acute respiratory syndrome coronavirus 2 infection, required oxygen therapy, and had adequate organ function. The planned sample size was 609 patients. Patients were randomized 1:1:1 to at least 3 days of dexamethasone plus either plitidepsin (1.5 mg/day or 2.5 mg/day, for 3 days) or standard of care (control). The primary endpoint was the time to sustained withdrawal of supplemental oxygen. Secondary endpoints included time to sustained hospital discharge, clinical status, duration of oxygen support, percentage of patients requiring admission to the intensive care unit, and safety. Results After randomizing 205 patients, NEPTUNO was discontinued due to a notable drop in COVID-19–related hospitalizations. Available data suggest a 2-day improvement in the median time to sustained oxygen therapy discontinuation (5 vs 7 days) favoring both plitidepsin arms (hazard ratio, 1.37; 95% confidence interval,.96–1.96; P =.08 for plitidepsin 1.5 mg vs control; hazard ratio, 1.06; 95% confidence interval,.73–1.53; P =.78 for plitidepsin 2.5 mg vs control). Plitidepsin was generally well tolerated. Conclusions Despite the trial limitations, these results suggest that plitidepsin may have a positive benefit-risk ratio in the management of patients requiring oxygen therapy. Further studies with plitidepsin, including those in immunosuppressed patients, are warranted. Results from this phase III trial suggest that plitidepsin, a first-in-class antiviral, may have a positive benefit-risk ratio in the management of hospitalized patients requiring oxygen therapy for moderate COVID-19. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
15. Predictors of poor prognosis in healthy, young, individuals with SARS-CoV-2 infections
- Author
-
Espejo-Paeres, Carolina, Espliguero, Ramón Arroyo, Uribarri, Aitor, Antón-Huguet, Berta, Romero, Rodolfo, Fernández-Rozas, Inmaculada, Becerra-Muñoz, Víctor Manuel, Alfonso-Rodríguez, Emilio, Huang, Jia, Ortega-Armas, María Elizabeth, Pepe, Martino, González, Adelina, Bertolazzi, Marzia, Cerrato, Enrico, Quezada, Antonio, Raposeiras-Roubin, Sergio, Vedia, Oscar, Feltes-Guzmán, Gisela, Akin, Ibrahim, Carrero-Fernández, Ana, Macaya, Carlos, Estrada, Vicente, and Núñez-Gil, Iván J.
- Published
- 2022
- Full Text
- View/download PDF
16. Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study
- Author
-
Coll, Pep, Cobarsi, Patricia, Nieto, Aroa, Meulbroek, Michael, Carrillo, Antonia, Saz, Jorge, Guerrero, Jorge D.R., García, Mar Vera, Gutiérrez, Felix, Masiá, Mar, Robledano, Catalina, Leon, Agathe, Leal, Lorna, Redondo, Eva G., Estrada, Vicente P., Marquez, Rocio, Sandoval, Raquel, Viciana, Pompeyo, Espinosa, Nuria, Lopez-Cortes, Luis, Podzamczer, Daniel, Tiraboschi, Juan, Morenilla, Sandra, Antela, Antonio, Losada, Elena, Nwokolo, Nneka, Sewell, Janey, Clarke, Amanda, Kirk, Sarah, Knott, Alyson, Rodger, Alison J, Fernandez, Thomas, Gompels, Mark, Jennings, Louise, Ward, Lana, Fox, Julie, Lwanga, Julianne, Lee, Ming, Gilson, Richard, Leen, Clifford, Morris, Sheila, Clutterbuck, Dan, Brady, Michael, Asboe, David, Fedele, Serge, Fidler, Sarah, Brockmeyer, Norbert, Potthoff, Anja, Skaletz-Rorowski, Adriane, Bogner, Johannes, Seybold, Ulrich, Roider, Julia, Jessen, Heiko, Jessen, Arne, Ruzicic, Slobodan, Stellbrink, Hans-Jürgen, Kümmerle, Tim, Lehmann, Clara, Degen, Olaf, Bartel, Sindy, Hüfner, Anja, Rockstroh, Jürgen, Mohrmann, Karina, Boesecke, Christoph, Krznaric, Ivanka, Ingiliz, Patrick, Weber, Rainer, Grube, Christina, Braun, Dominique, Günthard, Huldrych, Wandeler, Gilles, Furrer, Hansjakob, Rauch, Andri, Vernazza, Pietro, Schmid, Patrick, Rasi, Manuela, Borso, Denise, Stratmann, Markus, Caviezel, Oliver, Stoeckle, Marcel, Battegay, Manuel, Tarr, Philip, Christinet, Vanessa, Jouinot, Florent, Isambert, Camille, Bernasconi, Enos, Bernasconi, Beatrice, Gerstoft, Jan, Jensen, Lene P., Bayer, Anne A., Ostergaard, Lars, Yehdego, Yordanos, Bach, Ann, Handberg, Pia, Kronborg, Gitte, Pedersen, Svend s., Bülow, Nete, Ramskover, Bente, Ristola, Matti, Debnam, Outi, Sutinen, Jussi, Blaxhult, Anders, Ask, Ronnie, Hildingsson-Lundh, Bernt, Westling, Katarina, Frisen, Eeva-Maija, Cortney, Gráinne, O'Dea, Siobhan, De Wit, Stephane, Necsoi, Coca, Vandekerckhove, Linos, Goffard, Jean-Christophe, Henrard, Sophie, Prins, Jan, Nobel, Hans-Henrik, Weijsenfeld, Annouschka, Van Eeden, Arne, Elsenburg, Loek, Brinkman, Kees, Vos, Danielle, Hoijenga, Imke, Gisolf, Elisabeth, Van Bentum, Petra, Verhagen, Dominique, Raffi, Francois, Billaud, Eric, Ohayon, Michel, Gosset, Daniel, Fior, Alexandre, Pialoux, Gilles, Thibaut, Pelagie, Chas, Julie, Leclercq, Vincent, Pechenot, Vincent, Coquelin, Vincent, Pradier, Christian, Breaud, Sophie, Touzeau-Romer, Veronique, Rieger, Armin, Kitchen - Maria Geit, Maria, Sarcletti, Mario, Gisinger, Martin, Oellinger, Angela, Antinori, Andrea, Menichetti, Samanta, Bini, Teresa, Mussini, Cristina, Meschiari, Marianna, Di Biagio, Antonio, Taramasso, Lucia, Celesia, Benedetto M., Gussio, Maria, Janeiro, Nuno, Cambiano, Valentina, Bruun, Tina, Collins, Simon, Corbelli, Giulio Maria, Estrada, Vicente, Geretti, Anna Maria, Beloukas, Apostolos, Raben, Dorthe, Prins, Jan M, Brockmeyer, Norbert H, del Romero Guerrero, Jorge, Bogner, Johannes R, Kitchen, Maria, Phillips, Andrew N, and Lundgren, Jens
- Published
- 2019
- Full Text
- View/download PDF
17. Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial
- Author
-
Ahn, Mi-Young, Akasbi, Miriam, Alatorre-Alexander, Jorge, Altclas, Javier David, Ariel, Federico, Ariza, Horacio Alberto, Atkar, Chandrasekhar, Bertetti, Anselmo, Bhattacharya, Meenakshi, Briones, Maria Luisa, Budhraja, Akshay, Burza, Aaliya, Camacho Ortiz, Adrian, Caricchio, Roberto, Casas, Marcelo, Cevoli Recio, Valeria, Choi, Won Suk, Cohen, Emilia, Comulada-Rivera, Angel, Cook, Paul, Cornejo Juarez, Dora Patricia, Daniel, Carnevali, Degrecci Relvas, Luiz Fernando, Dominguez Cherit, Jose Guillermo, Ellerin, Todd, Enikeev, Dmitry, Erico Tanni Minamoto, Suzana, Estrada, Vicente, Fiss, Elie, Furuichi, Motohiko, Giovanni Luz, Kleber, Goldman, Jason D., Gonzalez, Omar, Gordeev, Ivan, Gruenewald, Thomas, Hamamoto Sato, Victor Augusto, Heo, Eun Young, Heo, Jung Yeon, Hermida, Maria, Hirai, Yuji, Hutchinson, David, Iastrebner, Claudio, Ioachimescu, Octavian, Jain, Manish, Juliani Souza Lima, Maria Patelli, Khan, Akram, Kremer, Andreas E., Lawrie, Thomas, MacElwee, Mark, Madhani-Lovely, Farah, Malhotra, Vinay, Martínez Resendez, Michel Fernando, McKinnell, James, Milligan, Patrick, Minelli, Cesar, Moran Rodriguez, Miguel Angel, Parody, Maria Leonor, Paulin, Priscila, Pellegrini, Rita de Cassia, Pemu, Priscilla, Procopio Carvalho, Ana Carolina, Puoti, Massimo, Purow, Joshua, Ramesh, Mayur, Rea Neto, Alvaro, Robinson, Philip, Rodrigues, Cristhieni, Rojas Velasco, Gustavo, Saraiva, Jose Francisco Kerr, Scheinberg, Morton, Schreiber, Stefan, Scublinsky, Dario, Sevciovic Grumach, Anete, Shawa, Imad, Simon Campos, Jesus, Sofat, Nidhi, Som, Mousumi, Spinner, Christoph D., Sprinz, Eduardo, Stienecker, Roger, Suarez, Jose, Tachikawa, Natsuo, Tahir, Hasan, Tiffany, Brian, Vishnevsky, Alexander, Westheimer Cavalcante, Adilson, Zirpe, Kapil, Marconi, Vincent C, Ramanan, Athimalaipet V, de Bono, Stephanie, Kartman, Cynthia E, Krishnan, Venkatesh, Liao, Ran, Piruzeli, Maria Lucia B, Goldman, Jason D, de Cassia Pellegrini, Rita, Cardoso, Anabela, Chakladar, Sujatro, Crowe, Brenda, Reis, Paulo, Zhang, Xin, Adams, David H, and Ely, E Wesley
- Published
- 2021
- Full Text
- View/download PDF
18. Atrial fibrillation in patients with COVID-19. Usefulness of the CHA2DS2-VASc score: an analysis of the international HOPE COVID-19 registry
- Author
-
Uribarri, Aitor, Núñez-Gil, Iván J., Aparisi, Álvaro, Arroyo-Espliguero, Ramón, Maroun Eid, Charbel, Romero, Rodolfo, Becerra-Muñoz, Víctor M., Feltes, Gisela, Molina, María, García-Aguado, Marcos, Cerrato, Enrico, Capel-Astrua, Thamar, Alfonso-Rodríguez, Emilio, Castro-Mejía, Alex F., Raposeiras-Roubín, Sergio, Espejo, Carolina, Pérez-Solé, Nerea, Bardají, Alfredo, Marín, Francisco, Fabregat-Andrés, Óscar, D’ascenzo, Fabrizio, Santoro, Francesco, Akin, Ibrahim, Estrada, Vicente, Fernández-Ortiz, Antonio, and Macaya, Carlos
- Published
- 2021
- Full Text
- View/download PDF
19. Fibrilación auricular en pacientes con COVID-19. Utilidad de la puntuación CHA2DS2-VASc: un análisis del registro internacional HOPE COVID-19
- Author
-
Uribarri, Aitor, Núñez-Gil, Iván J., Aparisi, Álvaro, Arroyo-Espliguero, Ramón, Maroun Eid, Charbel, Romero, Rodolfo, Becerra-Muñoz, Víctor M., Feltes, Gisela, Molina, María, García-Aguado, Marcos, Cerrato, Enrico, Capel-Astrua, Thamar, Alfonso-Rodríguez, Emilio, Castro-Mejía, Alex F., Raposeiras-Roubín, Sergio, Espejo, Carolina, Pérez-Solé, Nerea, Bardají, Alfredo, Marín, Francisco, Fabregat-Andrés, Óscar, D’ascenzo, Fabrizio, Santoro, Francesco, Akin, Ibrahim, Estrada, Vicente, Fernández-Ortiz, Antonio, and Macaya, Carlos
- Published
- 2021
- Full Text
- View/download PDF
20. Renin-angiotensin system inhibitors effect before and during hospitalization in COVID-19 outcomes: Final analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry
- Author
-
Núñez-Gil, Iván J., Olier, Iván, Feltes, Gisela, Viana-Llamas, María C., Maroun-Eid, Charbel, Romero, Rodolfo, Fernández-Rozas, Inmaculada, Uribarri, Aitor, Becerra-Muñoz, Victor M., Alfonso-Rodriguez, Emilio, García-Aguado, Marcos, Elola, Javier, Castro-Mejía, Alex, Pepe, Martino, Garcia-Prieto, Juan Fortunato, Gonzalez, Adelina, Ugo, Fabrizio, Cerrato, Enrico, Bondia, Elvira, Raposeiras-Roubin, Sergio, Mendez, Jorge L. Jativa, Espejo, Carolina, López-Masjuan, Álvaro, Marin, Francisco, López-Pais, Javier, Abumayyaleh, Mohammad, Corbi-Pascual, Miguel, Liebetrau, Christoph, Ramakrishna, Harish, Estrada, Vicente, Macaya, Carlos, and Fernandez-Ortiz, Antonio
- Published
- 2021
- Full Text
- View/download PDF
21. Does there exist an obesity paradox in COVID-19? Insights of the international HOPE-COVID-19-registry
- Author
-
Abumayyaleh, Mohammad, Núñez Gil, Iván J., El-Battrawy, Ibrahim, Estrada, Vicente, Becerra-Muñoz, Víctor Manuel, Aparisi, Alvaro, Fernández-Rozas, Inmaculada, Feltes, Gisela, Arroyo-Espliguero, Ramón, Trabattoni, Daniela, López-País, Javier, Pepe, Martino, Romero, Rodolfo, García, Diego Raúl Villavicencio, Biole, Carloalberto, Astrua, Thamar Capel, Eid, Charbel Maroun, Alfonso, Emilio, Fernandez-Presa, Lucia, Espejo, Carolina, Buonsenso, Danilo, Raposeiras, Sergio, Fernández, Cristina, Macaya, Carlos, and Akin, Ibrahim
- Published
- 2021
- Full Text
- View/download PDF
22. Prevalence and 30-Day Mortality in Hospitalized Patients With Covid-19 and Prior Lung Diseases
- Author
-
Signes-Costa, Jaime, Núñez-Gil, Iván J., Soriano, Joan B., Arroyo-Espliguero, Ramón, Eid, Charbel Maroun, Romero, Rodolfo, Uribarri, Aitor, Fernández-Rozas, Inmaculada, Aguado, Marcos García, Becerra-Muñoz, Víctor Manuel, Huang, Jia, Pepe, Martino, Cerrato, Enrico, Raposeiras, Sergio, Gonzalez, Adelina, Franco-Leon, Francisco, Wang, Lin, Alfonso, Emilio, Ugo, Fabrizio, García-Prieto, Juan Fortunato, Feltes, Gisela, Abumayyaleh, Mohammad, Espejo-Paeres, Carolina, Jativa, Jorge, Masjuan, Alvaro López, Macaya, Carlos, Carbonell Asíns, Juan A., and Estrada, Vicente
- Published
- 2021
- Full Text
- View/download PDF
23. COVID-19 anosmia and gustatory symptoms as a prognosis factor: a subanalysis of the HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry
- Author
-
Porta-Etessam, Jesús, Núñez-Gil, Iván J., González García, Nuria, Fernandez-Perez, Cristina, Viana-Llamas, María C., Eid, Charbel Maroun, Romero, Rodolfo, Molina, María, Uribarri, Aitor, Becerra-Muñoz, Victor Manuel, Aguado, Marcos García, Huang, Jia, Rondano, Elisa, Cerrato, Enrico, Alfonso, Emilio, Mejía, Alex Fernando Castro, Marin, Francisco, Roubin, Sergio Raposeiras, Pepe, Martino, Feltes, Gisela, Maté, Paloma, Cortese, Bernardo, Buzón, Luis, Mendez, Jorge Játiva, and Estrada, Vicente
- Published
- 2021
- Full Text
- View/download PDF
24. Interactions among the mycobiome, bacteriome, inflammation, and diet in people living with HIV
- Author
-
Gosalbes, María José, Jiménez-Hernández, Nuria, Moreno, Elena, Artacho, Alejandro, Pons, Xavier, Ruíz-Pérez, Sonia, Navia Lombán, Beatriz, Estrada, Vicente, Manzano, Mónica, Talavera-Rodríguez, Alba, Madrid, Nadia, Vallejo, Alejandro, Luna, Laura, Pérez-Molina, José Antonio, Moreno, Santiago, Serrano-Villar, Sergio, Gosalbes, María José, Jiménez-Hernández, Nuria, Moreno, Elena, Artacho, Alejandro, Pons, Xavier, Ruíz-Pérez, Sonia, Navia Lombán, Beatriz, Estrada, Vicente, Manzano, Mónica, Talavera-Rodríguez, Alba, Madrid, Nadia, Vallejo, Alejandro, Luna, Laura, Pérez-Molina, José Antonio, Moreno, Santiago, and Serrano-Villar, Sergio
- Abstract
While the intestinal microbiome seems a major driver of persistent immune defects in people with HIV (PWH), little is known about its fungal component, the mycobiome. We assessed the inter-kingdom mycobiome–bacteriome interactions, the impact of diet, and the association with the innate and adaptive immunity in PWH on antiretroviral therapy. We included 24 PWH individuals and 12 healthy controls. We sequenced the Internal Transcribed Spacer 2 amplicons, determined amplicon sequence variants, measured biomarkers of the innate and adaptive immunity in blood and relations with diet. Compared to healthy controls, PWH subjects exhibited a distinct and richer mycobiome and an enrichment for Debaryomyces hansenii, Candida albicans, and Candida parapsilosis. In PWH, Candida and Pichia species were strongly correlated with several bacterial genera, including Faecalibacterium genus. Regarding the links between the mycobiome and systemic immunology, we found a positive correlation between Candida species and the levels of proinflammatory cytokines (sTNF-R2 and IL-17), interleukin 22 (a cytokine implicated in the regulation of mucosal immunity), and CD8+ T cell counts. This suggests an important role of the yeasts in systemic innate and adaptive immune responses. Finally, we identified inter-kingdom interactions implicated in fiber degradation, short-chain fatty acid production, and lipid metabolism, and an effect of vegetable and fiber intake on the mycobiome. Therefore, despite the great differences in abundance and diversity between the bacterial and fungal communities of the gut, we defined the changes associated with HIV, determined several different inter-kingdom associations, and found links between the mycobiome, nutrient metabolism, and systemic immunity, European Development Regional Found "A way to achieve Europe" (ERDF), Instituto de Salud Carlos III, Depto. de Nutrición y Ciencia de los Alimentos, Fac. de Farmacia, TRUE, pub
- Published
- 2024
25. Personalized prescription of ACEI/ARBs for hypertensive COVID-19 patients
- Author
-
Bertsimas, Dimitris, Borenstein, Alison, Mingardi, Luca, Nohadani, Omid, Orfanoudaki, Agni, Stellato, Bartolomeo, Wiberg, Holly, Sarin, Pankaj, Varelmann, Dirk J., Estrada, Vicente, Macaya, Carlos, and Gil, Iván J. Núñez
- Published
- 2021
- Full Text
- View/download PDF
26. Clinical presentation, therapeutic approach, and outcome of young patients admitted for COVID-19, with respect to the elderly counterpart
- Author
-
Pepe, Martino, Maroun-Eid, Charbel, Romero, Rodolfo, Arroyo-Espliguero, Ramón, Fernàndez-Rozas, Inmaculada, Aparisi, Alvaro, Becerra-Muñoz, Víctor Manuel, Garcìa Aguado, Marcos, Brindicci, Gaetano, Huang, Jia, Alfonso-Rodríguez, Emilio, Castro-Mejía, Alex Fernando, Favretto, Serena, Cerrato, Enrico, Albiol, Paloma, Raposeiras-Roubin, Sergio, Vedia, Oscar, Feltes Guzmãn, Gisela, Carrero-Fernández, Ana, Perez Cimarra, Clara, Buzón, Luis, Jativa Mendez, Jorge Luis, Abumayyaleh, Mohammad, Corbi-Pascual, Miguel, Macaya, Carlos, Estrada, Vicente, Nestola, Palma Luisa, Biondi-Zoccai, Giuseppe, and Núñez-Gil, Iván J.
- Published
- 2021
- Full Text
- View/download PDF
27. Health Outcome Predictive Evaluation for COVID 19 international registry (HOPE COVID-19), rationale and design
- Author
-
Núñez-Gil, Iván J., Estrada, Vicente, Fernández-Pérez, Cristina, Feltes, Gisela, Vedia, Oscar, Vergara-Uzcategui, Carlos E., Moreno-Menguía, Víctor H., Cerrato, Enrico, D'Ascenzo, Fabrizio, Raposeiras-Roubin, Sergio, Martín-Sánchez, F. Javier, Alfonso-Rodríguez, Emilio, Huang, Jia, Ramakrishna, Harish, Gil-Higes, Emma, Fernández-Ortiz, Antonio, and Macaya, Carlos
- Published
- 2020
- Full Text
- View/download PDF
28. Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study
- Author
-
Jarrin, Inmaculada, Moreno, Santiago, Alejos, Belén, Muñoz-Fernández, MÁngeles, Consuegra, Irene, Merino, Esperanza, García, Gema, Lirola, Ana López, García, Dácil, Asensi, Víctor, Valle, Eulalia, Rubio, Rafael, Pulido, Federico, Iribarren, José Antonio, Arrizabalaga, Julio, Gutiérrez, Félix, Masiá, Mar, Muga, Roberto, Sanvisens, Arantza, Berenguer, Juan, Vidal, Francesc, Montero, Marta, Blanco, José Ramón, López Bernarlo de Quirós, Juan Carlos, González-Garcia, Juan, Peraire, Joaquín, Arazo, Piedad, López-Aldeguer, José, Dalmau, David, Arnalich, Francisco, Rivero, Maria, Oteo, José Antonio, Sampériz, Gloria, Amengual, María José, Jaén, Angels, de los Santos, Ignacio, Repáraz, Jesús, Navarro, Gemma, Bernal, Enrique, Sanz, Jesús, Viciana, Pompeyo, García, Federico, Casado, José Luis, Del Romero, Jorge, Cano, Alfredo, Antela, Antonio, Quero, José Hernández, Riera, Melchor, Raposo, Montserrat, Santos, Jesús, Losada, Elena, Daniel, Podzamczer, Peñaranda, María, Ayerbe, Cristina Gómez, Espinosa, Nuria, Olalla, Julián, Imaz, Arkaitz, Martínez, Onofre, Curran, Adrian, Castro, Ángeles, Pérez Stachowski, Javier, Muñoz, Josefa, Vera, Francisco Jesús, Galera, Carlos, Pernas, Berta, Amador, Concha, Zuriñe, Miren, Albendin, Helena, Suárez-García, Inés, Pasquau, Francisco, Omar, Mohamed, Malmierca, Eduardo, de Zarraga, Miguel Alberto, Gómez Vidal, María Amparo, Estrada, Vicente, Górgolas, Miguel, Sanz, José, Téllez, María Jesús, Galindo, María José, Cabello, Alfonso, Rivero, Antonio, Arranz, Alberto, Cervero, Miguel, Vilalta, Ramón, Pineda, Juan A, Rivero-Juárez, Antonio, Torres, Rafael, Poveda, Eva, Rincón, Pilar, Pérez, Alexandre, Moreno, Cristina, Portilla, Irene, Díaz-Flores, Felicitas, Rivas, María E, Bisbal, Otilia, Aramburu, María J, Padilla, Sergio, Fuster, Daniel, Gutiérrez, Isabel, Viladés, Consuelo, Blanes, Marino, Arribas, José Ramón, Ibarra, Valvanera, Sanmartí, Montse, de Alda, María Ruiz, Cervantes, Manel, Salas, Ana, Dronda, Fernando, Alcaraz, Antonia, Muñoz, Leopoldo, Rodríguez, Carmen, Ribas, María Angels, Viciana, Isabel, López-Cortés, Luis, Tiraboschi, Juan, del Arco, Alfonso, Martínez, Lorena, Mena, Álvaro, Mirena, Josu, Pérez, Aurora, Ena, Javier, González-Ruano, Patricia, Vergas, Jorge, Álvarez, Beatriz, Hernández, Cristina, Ferrer, Ana, López, Pedro, Macías, Juan, Crespo, Manuel, Navarro, Maria Luisa, Iniesta, Carlos, Agea, Iván, Gómez, Juan Luis, Suárez-Zarracina, Tomás, Hernando, Asunción, Camino, Xabier, Robledano, Catalina, Ramírez, Margarita, Veloso, Sergio, Tasias, María, Bernardino, Jose Ignacio, Metola, Luis, Cairó, Mireia, de León Cano, María Teresa, Calzado, Sonia, Sarria, Cristina, Moreno, Ana, Bravo, Joaquín, Alvarez, Marta, Puerta, Teresa, Campins, Antoni A, Palacios, Rosario, Silva, Ana, de la Torre, Javier, García, Josefina, Ibarra, Sofía, Iborra, Asunción, Benito, Concha, Martín, Dolores, Pérez-Somarriba, Juncal, Prieto, Laura, Novella, María, Machuca, Isabel, Merchante, Nicolás, Morano, Luis, González, Maria Isabel, García, Luis NM, Portilla, Joaquín, Alonso, María del Mar, Pérez, Laura, Domínguez, Lourdes, Rodríguez-Arrondo, Francisco, Colomé, Joan Gregori, Padilla, Belén, Vargas, Montserrat, Castro, Iván, Castro, Juan Miguel, Sanz, Mercedes, Martinez-Lacasa, Javier, Pierola, Beatriz, Navarro, Marta, Garcia-Fraile, Lucio, Pérez-Elias, Maria Jesús, Muñoz, Ángeles, Chueca, Natalia, Carrió, Juan Carlos, Vidal, Carmen, Pérez, Carmen, Saumoy, María, Prada, José Luis, Alcaraz, Begoña, Ferrero, Oscar, Moreno, Antonio, Fenoll, Vicenta, Ruiz, Mª Pilar, Frias, Mario, Real, Luis Miguel, Miralles, Celia, Garcia, Federico, Sanz, Nieves, Sánchez-Payá, José, Pelazas, Ricardo, Rial, David, von Wichman, Miguel Ángel, Adsuar, Araceli, Gijón, Paloma, Olona, Montserrat, Calabuig, Eva, Delgado, Ana, Pérez-Martínez, Laura, Velli, Pablo, Martín-Gayo, Enrique, Gutiérrez, Carolina, Alcaraz, Maria José, Vinuesa, David, Vera, Mar, Fanjul, Francisco, Gonzalez-Domenec, Carmen, Prieto, Paula, de las Lomas, José N García, Jimeno, Amaya, López, Josefina, Merlos, Maria, Gil, Concepción, Camacho, Angela, Corma, Anais, Ocampo, Antonio, Rava, Marta, Rodríguez, Juan Carlos, Hernández, Jehovana, Bermejo, Laura, Pascual, Lidia, Pascual, Rafael, Aldamiz-Echevarría, Teresa, Rull, Anna, Cuéllar, Sandra, Escosa, Luis, Font, Roser, Madrid, Nadia, del Carmen Villalba, Maria, Martinez-Montes, Clara, Ballesteros, Juan, Murillas, Javier, Cámara, María Mar, Vidal, Asunción, Algado, José Tomas, Fernández, Marta, Pousada, Guillermo, Iribarren, Jose Antonio, Gimeno, Lina, Alemán, María Remedios, Santacreu, Mireia, Goenaga, Miguel Ángel, Tejerina, Francisco, Rodríguez-Gallego, Esther, Salavert, Miguel, Herranz, Pedro, Martinez, Marina, del Campo, Santos, Guerrero, Carlos, Ayerdi, Oskar, Homar, Francisco, de la Peña, Mireia, Meca, Marisa, Díez, Marcos, Azkune, Harkaitz, Barber, Xavier, Balsalobre, Pascual, Castellanos, Alfonso Javier, García-Bujalance, Silvia, Vivancos, Maria Jesús, Fuentes, Ana, Martin, Maria Luisa, Lopez, Iñigo, Vilchez, Helem, Lopez, Miriam, Carreres, Melissa, Ibarguren, Maialen, Agullo, Vanessa, Diez, Cristina, López-Dupla, Miguel, García, Milagros, Umerez, Maitane, Martínez-Sanz, Javier, Payeras, Antoni, Reus, Sergio, Lizardi, Aitziber, Garcia, Javier, Pérez, Leire, González-Baeza, Alicia, Anxa, Usua, González, Juan, Boix, Vicente, Kortajarena, Xabier, Pascual, Reyes, Fanciulli, Chiara, Martín-Carbonero, Maria Luz, Mellado, Maria José, Micán, Rafael, Montejano, Rocio, Montes, María Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rúa, Guadalupe, Rodés, Berta, Sainz, Talia, Sendagorta, Elena, Stella, Natalia, Valencia, Eulalia, Velasco, Tamara, Muñoz-Fernández, María Ángeles, Torrús, Diego, Carmona, María Pilar, Roca, María, Mayoral, Mario, Vallejo, Alejandro, Serrano-Villar, Sergio, Ron, Raquel, Talavera-Rodríguez, Alba, Fernández-Felix, Borja M, Herrera, Sabina, Muriel, Alfonso, de Zárraga, Miguel Alberto, and Vivancos, María J
- Published
- 2020
- Full Text
- View/download PDF
29. La formación de valores identitarios desde la planificación de actividades docentes y extensionistas. Visión comprensivo – edificadora
- Author
-
Martínez Estrada, Vicente, primary, González Pérez, Ermis, additional, and Best Rivero, Aleida, additional
- Published
- 2024
- Full Text
- View/download PDF
30. Mpox, herpes, and enteroviruses: Differential diagnosis
- Author
-
Guillén‐Calvo, Laura, primary, Negredo, Anabel, additional, Sánchez‐Mora, Patricia, additional, Molero, Paqui, additional, Vázquez, Ana, additional, Cabrerizo, María, additional, Orviz, Eva, additional, Ledesma, Juan, additional, Estrada, Vicente, additional, Tarragó, David, additional, and Sánchez‐Seco, María Paz, additional
- Published
- 2024
- Full Text
- View/download PDF
31. Transcriptional signature of resting-memory CD4 T cells differentiates spontaneous from treatment-induced HIV control
- Author
-
García, Marcial, López-Fernández, Luis, Mínguez, Pablo, Morón-López, Sara, Restrepo, Clara, Navarrete-Muñoz, María A, López-Bernaldo, Juan Carlos, Benguría, Alberto, García, María Isabel, Cabello, Alfonso, Fernández-Guerrero, Manuel, De la Hera, Francisco Javier, Estrada, Vicente, Barros, Carlos, Martínez-Picado, Javier, Górgolas, Miguel, Benito, José M., and Rallón, Norma
- Published
- 2020
- Full Text
- View/download PDF
32. Predictive factors of renal impairment in HIV-infected patients on antiretroviral therapy: Results from the VACH longitudinal cohort study
- Author
-
Domingo, Pere, Suarez-Lozano, Ignacio, Gutierrez, Félix, Estrada, Vicente, Knobel, Hernando, Palacios, Rosario, Antela, Antonio, Blanco, José-Ramón, and Fulladosa, Xavier
- Published
- 2019
- Full Text
- View/download PDF
33. Rate of cardiovascular, renal and bone disease and their major risks factors in HIV-infected individuals on antiretroviral therapy in Spain
- Author
-
Knobel, Hernando, Domingo, Pere, Suarez-Lozano, Ignacio, Gutierrez, Félix, Estrada, Vicente, Palacios, Rosario, Antela, Antonio, Blanco, José-Ramón, Fulladosa, Xavier, and Refollo, Elena
- Published
- 2019
- Full Text
- View/download PDF
34. Executive summary of the GeSIDA/National AIDS Plan consensus document on antiretroviral therapy in adults infected by the human immunodeficiency virus (updated January 2018)
- Author
-
Pérez-Molina, José A., Polo, Rosa, López-Aldeguer, José, Lozano, Fernando, Aguirrebengoa, Koldo, Arribas, José Ramón, Boix, Vicente, Berenguer, Juan, Blanco, José Ramón, Domingo, Pere, Estrada, Vicente, Galindo, María José, García, Federico, Gatell, José María, González-García, Juan, Gutiérrez, Félix, Iribarren, José Antonio, Knobel, Hernando, Llibre, Josep María, López-Bernaldo de Quirós, Juan Carlos, López-Cortés, Luis Fernando, Losa, Juan Emilio, Mariño, Ana, Miró, José M., Montes, María L., Moreno, Santiago, Negredo, Eugenia, Pérez-Elías, María J., Podzamczer, Daniel, Portilla, Joaquín, Poveda, Eva, Pulido, Federico, Ribera, Esteban, Rivero, Antonio, Rubio, Rafael, Santos, Jesús, Sanz-Moreno, José, Sanz-Sanz, Jesús, Serrano, Sergio, de la Torre, Javier, Tuset, Montserrat, von Wichman, Miguel A., and Martínez, Esteban
- Published
- 2019
- Full Text
- View/download PDF
35. T Cell Homeostasis Disturbances in a Cohort of Long-Term Elite Controllers of HIV Infection.
- Author
-
Benito, José M., Jiménez-Carretero, Daniel, Restrepo, Clara, Ligos, José M., Valentín-Quiroga, Jaime, Mahillo, Ignacio, Cabello, Alfonso, López-Collazo, Eduardo, Sánchez-Cabo, Fátima, Górgolas, Miguel, Estrada, Vicente, and Rallón, Norma
- Subjects
T cells ,LONG-term non-progressors ,HIV infections ,IMMUNOSENESCENCE ,HOMEOSTASIS ,HIV-positive persons ,ANTIRETROVIRAL agents - Abstract
Elite controllers (ECs) are people living with HIV (PLWH) able to control HIV replication without antiretroviral therapy and have been proposed as a model of a functional HIV cure. Much evidence suggests that this spontaneous control of HIV has a cost in terms of T cell homeostasis alterations. We performed a deep phenotypic study to obtain insight into T cell homeostasis disturbances in ECs maintaining long-term virologic and immunologic control of HIV (long-term elite controllers; LTECs). Forty-seven PLWH were included: 22 LTECs, 15 non-controllers under successful antiretroviral therapy (onART), and 10 non-controllers not receiving ART (offART). Twenty uninfected participants (UCs) were included as a reference. T cell homeostasis was analyzed by spectral flow cytometry and data were analyzed using dimensionality reduction and clustering using R software v3.3.2. Dimensionality reduction and clustering yielded 57 and 54 different CD4 and CD8 T cell clusters, respectively. The offART group showed the highest perturbation of T cell homeostasis, with 18 CD4 clusters and 15 CD8 clusters significantly different from those of UCs. Most of these alterations were reverted in the onART group. Interestingly, LTECs presented several disturbances of T cell homeostasis with 15 CD4 clusters and 13 CD8 clusters different from UC. Moreover, there was a specific profile of T cell homeostasis alterations associated with LTECs, characterized by increases in clusters of naïve T cells, increases in clusters of non-senescent effector CD8 cells, and increases in clusters of central memory CD4 cells. These results demonstrate that, compared to ART-mediated control of HIV, the spontaneous control of HIV is associated with several disturbances in CD4 and CD8 T cell homeostasis. These alterations could be related to the existence of a potent and efficient virus-specific T cell response, and to the ability to halt disease progression by maintaining an adequate pool of CD4 T cells. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. A specific natural killer cells phenotypic signature associated to long term elite control of HIV infection.
- Author
-
Rallón, Norma, Jiménez‐Carretero, Daniel, Restrepo, Clara, Ligos, José M., Valentín‐Quiroga, Jaime, Mahillo, Ignacio, Cabello, Alfonso, López‐Collazo, Eduardo, Sánchez‐Cabo, Fátima, Górgolas, Miguel, Estrada, Vicente, and Benito, José M.
- Subjects
KILLER cells ,HIV infections ,INFECTION control ,LONG-term non-progressors ,HIV-positive persons - Abstract
Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) that control HIV replication without therapy. Among the mechanisms involved in this ability, natural killer (NK)‐cells have recently gained much attention. We performed an in‐deep phenotypic analysis of NK‐cells to search for surrogate markers associated with the long term spontaneous control of HIV. Forty‐seven PLWH (22 long‐term EC [PLWH‐long‐term elite controllers (LTECs)], 15 noncontrollers receiving antiretroviral treatment [ART] [PLWH‐onART], and 10 noncontrollers cART‐naïve [PLWH‐offART]), and 20 uninfected controls were included. NK‐cells homeostasis was analyzed by spectral flow cytometry using a panel of 15 different markers. Data were analyzed using FCSExpress and R software for unsupervised multidimensional analysis. Six different subsets of NK‐cells were defined on the basis of CD16 and CD56 expression, and the multidimensional analysis revealed the existence of 68 different NK‐cells clusters based on the expression levels of the 15 different markers. PLWH‐offART presented the highest disturbance of NK‐cells homeostasis and this was not completely restored by long‐term ART. Interestingly, long term spontaneous control of HIV (PLWH‐LTEC group) was associated with a specific profile of NK‐cells homeostasis disturbance, characterized by an increase of CD16dimCD56dim subset when compared to uninfected controls (UC) group and also to offART and onART groups (p < 0.0001 for the global comparison), an increase of clusters C16 and C26 when compared to UC and onART groups (adjusted p‐value < 0.05 for both comparisons), and a decrease of clusters C10 and C20 when compared to all the other groups (adjusted p‐value < 0.05 for all comparisons). These findings may provide clues to elucidate markers of innate immunity with a relevant role in the long‐term control of HIV. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
37. 2086 - DESCRIPTIVO DE CARACTERÍSTICAS SOCIODEMOGRÁFICAS, CLÍNICAS Y CONDUCTUALES DE LOS PACIENTES CON INFECCIÓN POR MPOX EN UN CENTRO DE ITS Y SU HOSPITAL DE REFERENCIA EN MADRID
- Author
-
Rodríguez-Gallardo, Laura María, primary, Orviz, Eva, additional, Ayerdi, Oskar, additional, Vera, Mar, additional, Puerta, Teresa, additional, Suárez-Robles, Miguel, additional, Estrada, Vicente, additional, and del Romero-Guerrero, jorge, additional
- Published
- 2023
- Full Text
- View/download PDF
38. 2104 - DIAGNÓSTICO CONCOMITANTE DE MPOX Y OTRAS INFECCIONES DE TRANSMISIÓN SEXUAL
- Author
-
Cuchillo, Julia Barrado, primary, Orviz, Eva, additional, Ayerdi, Oskar, additional, Vera, Mar, additional, García, Jorge Alfredo Pérez, additional, Armenteros, Inés, additional, Guerrero, Jorge del Romero, additional, and Estrada, Vicente, additional
- Published
- 2023
- Full Text
- View/download PDF
39. 2065 - HÁBITOS DE CONSUMO EN PACIENTES CON DIAGNÓSTICO DE MPOX
- Author
-
Cuchillo, Julia Barrado, primary, Orviz, Eva, additional, Ayerdi, Oskar, additional, Gómez, Ana Muñoz, additional, Puerta, Teresa, additional, Cabello, Noemí, additional, Estrada, Vicente, additional, and Guerrero, Jorge del Romero, additional
- Published
- 2023
- Full Text
- View/download PDF
40. Differences in the inflammatory response among hospitalized patients with distinct variants of SARS-CoV-2
- Author
-
Homen-Fernandez, Jose-Reynaldo, primary, Valls, Adrián, additional, García, Ana, additional, Cabello, Noemí, additional, Ortega, Isabel, additional, Orviz, Eva, additional, Foncubierta, Carlos, additional, Martínez, Mercedes, additional, and Estrada, Vicente, additional
- Published
- 2023
- Full Text
- View/download PDF
41. Executive summary of the consensus document on osteoporosis in HIV-infected individuals
- Author
-
Negredo, Eugenia, Domingo, Pere, Gutièc)rrez, Fèc)lix, Galindo, María Josèc), Knobel, Hernando, Lozano, Fernando, Martínez, Esteban, Masiá, Mar, Polo, Rosa, and Estrada, Vicente
- Published
- 2018
- Full Text
- View/download PDF
42. Tenofovir alafenamide plus emtricitabine versus abacavir plus lamivudine for treatment of virologically suppressed HIV-1-infected adults: a randomised, double-blind, active-controlled, non-inferiority phase 3 trial
- Author
-
Winston, Alan, Post, Frank A, DeJesus, Edwin, Podzamczer, Daniel, Di Perri, Giovanni, Estrada, Vicente, Raffi, François, Ruane, Peter, Peyrani, Paula, Crofoot, Gordon, Mallon, Patrick W G, Castelli, Francesco, Yan, Mingjin, Cox, Stephanie, Das, Moupali, Cheng, Andrew, and Rhee, Martin S
- Published
- 2018
- Full Text
- View/download PDF
43. HIV-DNA content in pTfh cells is associated with residual viremia in elite controllers
- Author
-
García, Marcial, Morcilla, Vincent, Navarrete-Muñoz, Maria Ángeles, Fisher, Katie, Cabello, Alfonso, López-Bernaldo, Juan Carlos, De La Hera, Francisco, Barros, Carlos, Fernández-Guerrero, Manuel, Estrada, Vicente, Górgolas, Miguel, Benito, José Miguel, Palmer, Sarah, and Rallón, Norma
- Published
- 2021
- Full Text
- View/download PDF
44. Switching to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus darunavir/cobicistat in heavily antiretroviral-experienced, virologically suppressed HIV-infected adults receiving complex regimens
- Author
-
Podzamczer, Daniel, primary, Imaz, Arkaitz, additional, Lopez-Lirola, Ana, additional, Knobel, Hernando, additional, Masiá, Mar, additional, Fanciulli, Chiara, additional, Hernández, Cristina, additional, Lagarde, María, additional, Gutierrez, Angela, additional, Curran, Adrià, additional, Morano, Luis, additional, Montero-Alonso, Marta, additional, Troya, Jesús, additional, Rigo, Raúl, additional, Casadellà, María, additional, Navarro-Alcaraz, Antonio, additional, Ardila, Fernando, additional, Parera, Mariona, additional, Bernal, Enrique, additional, Echeverria, Patricia, additional, Estrada, Vicente, additional, Hidalgo-Tenorio, Carmen, additional, Macias, Juan, additional, Prieto, Paula, additional, Portilla, Joaquín, additional, Valencia, Eulalia, additional, Vivancos, María Jesús, additional, and Rivero, Antonio, additional
- Published
- 2023
- Full Text
- View/download PDF
45. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events
- Author
-
Martínez-Sanz, Javier, primary, Díaz-Álvarez, Jorge, additional, Rosas Cancio-Suarez, Marta, additional, Ron, Raquel, additional, Iribarren, José Antonio, additional, Bernal, Enrique, additional, Gutiérrez, Félix, additional, Ruiz Sancho, Andrés, additional, Cabello, Noemi, additional, Olalla, Julián, additional, Moreno, Santiago, additional, Serrano-Villar, Sergio, additional, Jarrín, Inma, additional, Dalmau, David, additional, Navarro, M. Luisa, additional, González, M. Isabel, additional, Garcia, Federico, additional, Poveda, Eva, additional, Iribarren, Jose Antonio, additional, Rubio, Rafael, additional, Vidal, Francesc, additional, Berenguer, Juan, additional, González, Juan, additional, Muñoz-Fernández, M. Ángeles, additional, Jarrín, Inmaculada, additional, Moreno, Cristina, additional, Rava, Marta, additional, Izquierdo, Rebeca, additional, Mauleón, Elba, additional, Portilla, Joaquín, additional, Portilla, Irene, additional, Merino, Esperanza, additional, García, Gema, additional, Agea, Iván, additional, Sánchez-Payá, José, additional, Rodríguez, Juan Carlos, additional, Giner, Livia, additional, Reus, Sergio, additional, Boix, Vicente, additional, Torrus, Diego, additional, Pérez, Verónica, additional, Portilla, Julia, additional, Gómez, Juan Luís, additional, Hernández, Jehovana, additional, Lirola, Ana López, additional, García, Dácil, additional, Díaz-Flores, Felicitas, additional, Alonso, M. Mar, additional, Pelazas, Ricardo, additional, Alemán, M. Remedios, additional, Asensi, Víctor, additional, Rivas Carmenado, María Eugenia, additional, Suarez-Zarracina, Tomás, additional, Pulido, Federico, additional, Bisbal, Otilia, additional, Hernando, M. Asunción, additional, Rial, David, additional, de Lagarde, María, additional, Arce, Octavio, additional, Pinto, Adriana, additional, Bermejo, Laura, additional, Santacreu, Mireia, additional, Navarro, Roser, additional, Gonzalez, Candela, additional, Aramburu, M. José, additional, Camino, Xabier, additional, Ángel von Wichmann, Miguel, additional, Goenaga, Miguel Ángel, additional, Bustinduy, M. Jesús, additional, Azkune, Harkaitz, additional, Ibarguren, Maialen, additional, Kortajarena, Xabier, additional, Álvarez-Rodriguez, Ignacio, additional, Gil, Leire, additional, Martínez, Lourdes, additional, Robledano, Catalina, additional, Masiá, Mar, additional, Padilla, Sergio, additional, Adsuar, Araceli, additional, Pascual, Rafael, additional, Fernández, Marta, additional, Galiana, Antonio, additional, García, José Alberto, additional, Barber, Xavier, additional, Agullo, Vanessa, additional, Abellán, Javier Garcia, additional, Pascual, Reyes, additional, Telenti, Guillermo, additional, Guillén, Lucia, additional, Botella, Ángela, additional, Muga, Roberto, additional, Sanvisens, Arantza, additional, Fuster, Daniel, additional, Gutierrez, Isabel, additional, López, Juan Carlos, additional, Ramírez, Margarita, additional, Padilla, Belén, additional, Gijón, Paloma, additional, Aldamiz-Echevarría, Teresa, additional, Tejerina, Francisco, additional, Diez, Cristina, additional, Pérez, Leire, additional, Fanciulli, Chiara, additional, Corral, Saray, additional, Martí, Anna, additional, Peraire, Joaquín, additional, Viladés, Consuelo, additional, Vargas, Montserrat, additional, Olona, Montserrat, additional, Rull, Anna, additional, Alba, Verónica, additional, Yeregui, Elena, additional, Masip, Jenifer, additional, García-Pardo, Graciano, additional, Bertomeu, Frederic Gómez, additional, Espineira, Sonia, additional, Montero, Marta, additional, Cuéllar, Sandra, additional, Blanes, Marino, additional, Tasias, María, additional, Calabuig, Eva, additional, Salavert, Miguel, additional, Fernández, Juan, additional, Segarra, Inmaculada, additional, González-García, Juan, additional, Delgado, Ana, additional, Arnalich, Francisco, additional, Arribas, José Ramón, additional, Bernardino, Jose Ignacio, additional, Castro, Juan Miguel, additional, Escosa, Luis, additional, Herranz, Pedro, additional, Hontañón, Victor, additional, García-Bujalance, Silvia, additional, García, Milagros, additional, González-Baeza, Alicia, additional, Martín-Carbonero, M. Luz, additional, Mayoral, Mario, additional, Mellado, M. Jose, additional, Esteban, Rafael, additional, Montejano, Rocío, additional, Montes, M. Luisa, additional, Moreno, Victoria, additional, Pérez-Valero, Ignacio, additional, Rodés, Berta, additional, Rúa, Guadalupe, additional, Sainz, Talía, additional, Sendagorta, Elena, additional, Valencia, Eulalia, additional, Busca, Carmen, additional, Cano, Joanna, additional, Cardiñanos, Julen, additional, de Miguel, Rosa, additional, Blanco, Jose Ramón, additional, Pérez-Martínez, Laura, additional, Oteo, José Antonio, additional, Ibarra, Valvanera, additional, Metola, Luis, additional, Sanz, Mercedes, additional, Arazo, Piedad, additional, Sampériz, Gloria, additional, Martinez, Marina, additional, Jaén, Angels, additional, Sanmartí, Montse, additional, Cairó, Mireia, additional, Martinez-Lacasa, Javier, additional, Velli, Pablo, additional, Font, Roser, additional, Xercavins, Mariona, additional, Alonso, Noemí, additional, Aiello, Francesco, additional, Rivero, María, additional, Piérola, Beatriz, additional, Goikoetxea, Maider, additional, Gracia, María, additional, Ibero, Carlos, additional, Moreno, Estela, additional, Repáraz, Jesús, additional, Navarro, Gemma, additional, Garcia, Manel Cervantes, additional, Isbert, Sonia Calzado, additional, Vilasaro, Marta Navarro, additional, Garcia, Belen Lopez, additional, Santos, Ignacio de los, additional, Santos, Alejandro de los, additional, Sanz, Jesús, additional, García-Fraile, Lucio, additional, Martín, Enrique, additional, Sánchez-Cerrillo, Ildefonso, additional, Calvet, Marta, additional, Barrios, Ana, additional, Bautista, Azucena, additional, Sáez, Carmen, additional, Ciudad, Marianela, additional, Gutiérrez, Ángela, additional, Campo, Santos del, additional, Casado, José Luis, additional, Dronda, Fernando, additional, Moreno, Ana, additional, Pérez, M. Jesús, additional, Serrano, Sergio, additional, Vivancos, Ma Jesús, additional, Martínez-Sanz, Javier, additional, Vallejo, Alejandro, additional, Sanchez, Matilde, additional, Pérez-Molina, Jose Antonio, additional, Hermida, José Manuel, additional, Alcaraz, Antonia, additional, Bravo, Joaquín, additional, Muñoz, Ángeles, additional, Tomás, Cristina, additional, Martínez, Mónica, additional, Villalba, M. Carmen, additional, García, Federico, additional, Martínez, Clara, additional, Hernández, José, additional, Medina, Leopoldo Muñoz, additional, Álvarez, Marta, additional, Chueca, Natalia, additional, Vinuesa, David, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Guirao, Emilio, additional, Viñuela, Laura, additional, Ruiz-Sancho, Andrés, additional, Anguita, Francisco, additional, Del Romero, Jorge, additional, Raposo, Montserrat, additional, Rodríguez, Carmen, additional, Puerta, Teresa, additional, Carrió, Juan Carlos, additional, Vera, Mar, additional, Ballesteros, Juan, additional, Ayerdi, Oskar, additional, Baza, Begoña, additional, Orviz, Eva, additional, Antela, Antonio, additional, Losada, Elena, additional, Riera, Melchor, additional, Peñaranda, María, additional, Ribas, M. Angels, additional, Campins, Antoni A., additional, Garcia-Gazalla, Mercedes, additional, Fanjul, Francisco J., additional, Murillas, Javier, additional, Homar, Francisco, additional, Vilchez, Helem H., additional, Martin, Luisa, additional, Payeras, Antoni, additional, Santos, Jesús, additional, López, María, additional, Gómez, Crisitina, additional, Viciana, Isabel, additional, Palacios, Rosario, additional, López-Cortés, Luis Fernando, additional, Espinosa, Nuria, additional, Roca, Cristina, additional, Llaves, Silvia, additional, Tiraboschi, Juan Manuel, additional, Imaz, Arkaitz, additional, Silva, Ana Karina, additional, Saumoy, María, additional, Scévola, Sofía Catalina, additional, Curran, Adrián, additional, Falcó, Vicenç, additional, Navarro, Jordi, additional, Burgos, Joaquin, additional, Suanzes, Paula, additional, García, Jorge, additional, Descalzo, Vicente, additional, Álvarez, Patricia, additional, Planas, Bibiana, additional, Sanchiz, Marta, additional, Rodríguez, Lucía, additional, Sánchez, M José, additional, Pérez, Javier, additional, Arco, Alfonso del, additional, Torre, Javier de la, additional, Prada, José Luis, additional, Martínez, Onofre Juan, additional, Martinez, Lorena, additional, Vera, Francisco Jesús, additional, García, Josefina, additional, Alcaraz, Begoña, additional, Sánchez Guirao, Antonio Jesús, additional, Mena, Alvaro, additional, Castro, Angeles, additional, Pernas, Berta, additional, Vázquez, Pilar, additional, López, Soledad, additional, Ibarra, Sofía, additional, García, Guillermo, additional, Mirena, Josu, additional, Ferrero, Oscar Luis, additional, López, Josefina, additional, Cámara, M. Mar, additional, Peña, Mireia de la, additional, Lopez, Miriam, additional, Lopez, Iñigo, additional, Lombide, Itxaso, additional, Polo, Victor, additional, de Miguel, Joana, additional, Galera, Carlos, additional, Fernández, Marian, additional, Albendin, Helena, additional, Castillo, Antonia, additional, Iborra, Asunción, additional, Moreno, Antonio, additional, Merlos, M. Angustias, additional, Vidal, Asunción, additional, Amador, Concha, additional, Pasquau, Francisco, additional, Gil, Concepcion, additional, Algado, Jose Tomás, additional, Suarez-García, Inés, additional, Malmierca, Eduardo, additional, González-Ruano, Patricia, additional, Ruiz, M. Pilar, additional, Pascual, José Francisco, additional, Sáez, Elena, additional, Balsalobre, Luz, additional, López, M. Villa, additional, Omar, Mohamed, additional, Herrero, Carmen, additional, Gómez, M. Amparo, additional, Alberto de Zarraga, Miguel, additional, Pérez, Desiré, additional, Estrada, Vicente, additional, Sanz, Nieves, additional, Cabello, Noemí, additional, García, Jorge Vergas, additional, Núñez, Maria Jose, additional, Sagastagoitia, Iñigo, additional, Górgolas, Miguel, additional, Cabello, Alfonso, additional, Álvarez, Beatriz, additional, Prieto, Laura, additional, Carrillo, Irene, additional, Sanz, José, additional, Arranz, Alberto, additional, Hernández, Cristina, additional, Novella, María, additional, Galindo, M. José, additional, Ferrer, Ana, additional, Román, Antonio Rivero, additional, Ruíz, Inma, additional, Juárez, Antonio Rivero, additional, López, Pedro, additional, Machuca, Isabel, additional, Frias, Mario, additional, Camacho, Ángela, additional, Pérez, Ignacio, additional, Corona, Diana, additional, Cervero, Miguel, additional, Torres, Rafael, additional, Pineda, Juan Antonio, additional, Rincón, Pilar, additional, Macías, Juan, additional, Real, Luis Miguel, additional, Corma, Anais, additional, Gonzalez-Serna, Alejandro, additional, Pérez, Alexandre, additional, Morano, Luis, additional, Miralles, Celia, additional, Ocampo, Antonio, additional, Pousada, Guillermo, additional, Patiño, Lucía, additional, Dueñas, Carlos, additional, Gutiérrez, Sara, additional, Tapia, Elena, additional, Novoa, Cristina, additional, Egües, Xjoylin, additional, and Telleria, Pablo, additional
- Published
- 2023
- Full Text
- View/download PDF
46. Costs and cost-efficacy analysis of the 2016 GESIDA/Spanish AIDS National Plan recommended guidelines for initial antiretroviral therapy in HIV-infected adults
- Author
-
Rivero, Antonio, Pérez-Molina, José Antonio, Blasco, Antonio Javier, Arribas, José Ramón, Crespo, Manuel, Domingo, Pere, Estrada, Vicente, Iribarren, José Antonio, Knobel, Hernando, Lázaro, Pablo, López-Aldeguer, José, Lozano, Fernando, Moreno, Santiago, Palacios, Rosario, Pineda, Juan Antonio, Pulido, Federico, Rubio, Rafael, de la Torre, Javier, Tuset, Montserrat, and Gatell, Josep M.
- Published
- 2017
- Full Text
- View/download PDF
47. Interplay between gut microbiota metabolism and inflammation in HIV infection
- Author
-
Vázquez-Castellanos, Jorge F., Serrano-Villar, Sergio, Jiménez-Hernández, Nuria, Soto del Rio, María Dolores, Gayo, Sara, Rojo, David, Ferrer, Manuel, Barbas, Coral, Moreno, Santiago, Estrada, Vicente, Rattei, Tomas, Latorre, Amparo, Moya, Andrés, and Gosalbes, María José
- Published
- 2018
- Full Text
- View/download PDF
48. TRPC6 inhibitor (BI 764198) to reduce risk and severity of ARDS due to COVID-19: a phase II randomised controlled trial
- Author
-
Ware, Lorraine B, primary, Soleymanlou, Nima, additional, McAuley, Danny Francis, additional, Estrada, Vicente, additional, Diaz, George A, additional, Lacamera, Peter, additional, Kaste, Renee, additional, Choi, Wansuk, additional, Gupta, Abhya, additional, and Welte, Tobias, additional
- Published
- 2023
- Full Text
- View/download PDF
49. Faster lung function decline in people living with HIV despite adequate treatment:a longitudinal matched cohort study
- Author
-
Thudium, Rebekka Faber, Ronit, Andreas, Afzal, Shoaib, Colak, Yunus, Forman, Julie Lyng, Mendo, Fernando, Chen, Fabian, Estrada, Vicente, Kumarasamy, Nagalingeswaran, Nordestgaard, Borge G., Lundgren, Jens, Vestbo, Jørgen, Kunisaki, Ken M., Nielsen, Susanne Dam, Thudium, Rebekka Faber, Ronit, Andreas, Afzal, Shoaib, Colak, Yunus, Forman, Julie Lyng, Mendo, Fernando, Chen, Fabian, Estrada, Vicente, Kumarasamy, Nagalingeswaran, Nordestgaard, Borge G., Lundgren, Jens, Vestbo, Jørgen, Kunisaki, Ken M., and Nielsen, Susanne Dam
- Abstract
Introduction Chronic lung disease is common among people living with HIV (PLWH). We hypothesised that PLWH receiving antiretroviral therapy (ART) have faster lung function decline than matched controls. Methods We performed a prospective matched cohort study by including ART-treated PLWH from the Copenhagen Co-morbidity in HIV Infection Study (n=705) and the INSIGHT Strategic Timing of Antiretroviral Treatment Pulmonary Substudy (n=425) and frequency matched population controls from the Copenhagen General Population Study (n=2895) in a 1:3 ratio. Eligible participants were ≥25 years old and had two spirometry tests separated by at least 2 years of follow-up. Forced expiratory volume in 1 s (FEV1) decline (mL/year) was compared between PLWH and controls using a linear mixed model adjusted for age, sex, ethnicity and smoking status. Effect modification by smoking was investigated in subgroup analyses. Results The majority of PLWH were virally suppressed (96.1%). The adjusted mean annual decline in FEV1 was faster in PLWH than in controls with 36.4 (95% CI 33.7 to 39.1) vs 27.9 (95% CI 26.9 to 28.8) mL/year, yielding a difference of 8.5 (95% CI 5.6 to 11.4) mL/year. The association between HIV and FEV1 decline was modified by smoking, with the largest difference in current smokers (difference: 16.8 (95% CI 10.5 to 23.0) mL/year) and the smallest difference in never-smokers (difference: 5.0 (95% CI 0.7 to 9.3) mL/year). FEV1 decline >40 mL/year was more prevalent in PLWH (adjusted OR: 1.98 (95% CI 1.67 to 2.34)). Conclusion Well-treated PLWH have faster lung function decline than controls and smoking seems to modify this association, suggesting that smoking may lead to more rapid lung function decline in PLWH than in controls., Introduction Chronic lung disease is common among people living with HIV (PLWH). We hypothesised that PLWH receiving antiretroviral therapy (ART) have faster lung function decline than matched controls.Methods We performed a prospective matched cohort study by including ART-treated PLWH from the Copenhagen Co-morbidity in HIV Infection Study (n=705) and the INSIGHT Strategic Timing of Antiretroviral Treatment Pulmonary Substudy (n=425) and frequency matched population controls from the Copenhagen General Population Study (n=2895) in a 1:3 ratio. Eligible participants were >= 25 years old and had two spirometry tests separated by at least 2 years of follow-up. Forced expiratory volume in 1 s (FEV1) decline (mL/year) was compared between PLWH and controls using a linear mixed model adjusted for age, sex, ethnicity and smoking status. Effect modification by smoking was investigated in subgroup analyses.Results The majority of PLWH were virally suppressed (96.1%). The adjusted mean annual decline in FEV1 was faster in PLWH than in controls with 36.4 (95% CI 33.7 to 39.1) vs 27.9 (95% CI 26.9 to 28.8) mL/year, yielding a difference of 8.5 (95% CI 5.6 to 11.4) mL/year. The association between HIV and FEV1 decline was modified by smoking, with the largest difference in current smokers (difference: 16.8 (95% CI 10.5 to 23.0) mL/year) and the smallest difference in never-smokers (difference: 5.0 (95% CI 0.7 to 9.3) mL/year). FEV1 decline >40 mL/year was more prevalent in PLWH (adjusted OR: 1.98 (95% CI 1.67 to 2.34)).Conclusion Well-treated PLWH have faster lung function decline than controls and smoking seems to modify this association, suggesting that smoking may lead to more rapid lung function decline in PLWH than in controls.
- Published
- 2023
50. Specific Cellular and Humoral Immune Responses to the Neoantigen RBD of SARS-CoV-2 in Patients with Primary and Secondary Immunodeficiency and Healthy Donors
- Author
-
Mohamed, Kauzar Mohamed, Guevara-Hoyer, Kissy, García, Carlos Jiménez, Bravo, Laura García, Jiménez-Huete, Adolfo, de la Peña, Antonia Rodríguez, Valeros, Beatriz Mediero, Velázquez, Cristina Cañizares, López, Esther Culebras, Cabello, Noemí, Estrada, Vicente, Corbí, Ángel L., Fernández-Arquero, Miguel, Ocaña, Alberto, Delgado-Iribarren, Alberto, Martínez-Novillo, Mercedes, Bolaños, Estefanía, Anguita, Eduardo, Peña, Ascensión, Benavente, Celina, Benítez Fuentes, Javier David, Pérez Segura, Pedro, Sánchez-Ramón, Silvia, Mohamed, Kauzar Mohamed, Guevara-Hoyer, Kissy, García, Carlos Jiménez, Bravo, Laura García, Jiménez-Huete, Adolfo, de la Peña, Antonia Rodríguez, Valeros, Beatriz Mediero, Velázquez, Cristina Cañizares, López, Esther Culebras, Cabello, Noemí, Estrada, Vicente, Corbí, Ángel L., Fernández-Arquero, Miguel, Ocaña, Alberto, Delgado-Iribarren, Alberto, Martínez-Novillo, Mercedes, Bolaños, Estefanía, Anguita, Eduardo, Peña, Ascensión, Benavente, Celina, Benítez Fuentes, Javier David, Pérez Segura, Pedro, and Sánchez-Ramón, Silvia
- Abstract
Patients with antibody deficiency disorders, such as primary immunodeficiency (PID) or secondary immunodeficiency (SID) to B-cell lymphoproliferative disorder (B-CLPD), are two groups vulnerable to developing the severe or chronic form of coronavirus disease caused by SARS-CoV-2 (COVID-19). The data on adaptive immune responses against SARS-CoV-2 are well described in healthy donors, but still limited in patients with antibody deficiency of a different cause. Herein, we analyzed spike-specific IFN-γ and anti-spike IgG antibody responses at 3 to 6 months after exposure to SARS-CoV-2 derived from vaccination and/or infection in two cohorts of immunodeficient patients (PID vs. SID) compared to healthy controls (HCs). Pre-vaccine anti-SARS-CoV-2 cellular responses before vaccine administration were measured in 10 PID patients. Baseline cellular responses were detectable in 4 out of 10 PID patients who had COVID-19 prior to vaccination, perceiving an increase in cellular responses after two-dose vaccination (p < 0.001). Adequate specific cellular responses were observed in 18 out of 20 (90%) PID patients, in 14 out of 20 (70%) SID patients and in 74 out of 81 (96%) HCs after vaccination (and natural infection in some cases). Specific IFN-γ response was significantly higher in HC with respect to PID (1908.5 mUI/mL vs. 1694.1 mUI/mL; p = 0.005). Whereas all SID and HC patients mounted a specific humoral immune response, only 80% of PID patients showed positive anti-SARS-CoV-2 IgG. The titer of anti-SARS-CoV-2 IgG was significantly lower in SID compared with HC patients (p = 0.040), without significant differences between PID and HC patients (p = 0.123) and between PID and SID patients (p =0.683). High proportions of PID and SID patients showed adequate specific cellular responses to receptor binding domain (RBD) neoantigen, with a divergence between the two arms of the adaptive immune response in PID and SID patients. We al
- Published
- 2023
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.