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6 results on '"Etcheverry, Florencia"'

1. Adherence to a supplemented Mediterranean diet drives changes in the gut microbiota of HIV-1-infected individuals

Author

Barcelona Supercomputing Center, Pastor Ibáñez, Roque, Blanco Heredia, Juan, Etcheverry, Florencia, Sánchez Palomino, Sonsoles, Torrents, David, Barcelona Supercomputing Center, Pastor Ibáñez, Roque, Blanco Heredia, Juan, Etcheverry, Florencia, Sánchez Palomino, Sonsoles, and Torrents, David

Abstract

Objective: The health effects of a supplemented Mediterranean diet (SMD) with extra-virgin olive oil (EVOO) and nuts are well documented in non-HIV-infected individuals. We hypothesised that the benefits of an SMD could be mediated by changes in the gut microbiota, even in those with an altered intestinal microbiota such as people living with HIV. Design: Individuals living with HIV (n = 102) were randomised to receive an SMD with 50 g/day of EVOO and 30 g/day of walnuts (SMD group) or continue with their regular diet (control group) for 12 weeks. Methods: Adherence to the Mediterranean diet was assessed using the validated 14-item MD-Adherence-Screener (MEDAS) from the PREDIMED study. A sub-study classifying the participants according to their MEDAS scores was performed. Results: The lipid profile was improved in the SMD group vs. that in the control group (delta-total cholesterol and delta-B-lipoprotein). The immune activation (CD4+HLADR+CD38+ and CD8+HLADR+CD38+ cells) and IFN-γ-producing T-cells significantly decreased at week 12 compared to the baseline in the SMD group but not in the control group. The gut microbiota in those from the high-adherence group presented significantly high diversity and richness at the end of the intervention. Succinivibrio and Bifidobacterium abundances were influenced by the adherence to the MD and significantly correlated with Treg cells. Conclusion: The Mediterranean diet improved metabolic parameters, immune activation, Treg function, and the gut microbiota composition in HIV-1-infected individuals. Further, Mediterranean diet increased the Bifidobacterium abundances after the intervention, and it was associated to a beneficial profile, This study was partially supported by the SPANISH AIDS Research Network (RIS) grants RD16/0025/0002 and RD16/0025/0013 integrated in the State Plan for Scientific and Technical Research and Innovation from the General Sub-Directorate for Research Assessment and Promotion, Spanish Carlos III Institute of Health (ISCIII) co-funded by the European Regional Development Fund (ERDF), 6ª Announcement of Gilead Grants in Biomedical Research in HIV, Hepatic, and Hemo-Oncology, the Spanish Ministry of Economy (MINECO) (grant: SAF2015-66193-R), and income from Europe via the Regional Development (FEDER) and CERCA Programme/Generalitat de Catalunya SGR 615 and SGR 653. F.G. has received support from José María Segovia de Arana contracts. N.R. is a Miguel Servet II investigator from the ISCIII [grant CPII19/00025]. M.N.M. is funded by the grant IND2018/BMD-9651., Peer Reviewed, "Article signat per 18 autors/es: Roque Pastor-Ibáñez, Juan Blanco-Heredia, Florencia Etcheverry, Sonsoles Sánchez-Palomino, Francisco Díez-Fuertes, Rosa Casas, María Ángeles Navarrete-Muñoz, Sara Castro-Barquero, Constanza Lucero, Irene Fernández, Lorna Leal, José Miguel Benito, Marc Noguera-Julian, Roger Paredes, Norma Rallón, Ramón Estruch, David Torrents and Felipe García", Postprint (published version)

Published
2021

2. Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals

Author

Pastor-Ibáñez, Roque, primary, Blanco-Heredia, Juan, additional, Etcheverry, Florencia, additional, Sánchez-Palomino, Sonsoles, additional, Díez-Fuertes, Francisco, additional, Casas, Rosa, additional, Navarrete-Muñoz, María Ángeles, additional, Castro-Barquero, Sara, additional, Lucero, Constanza, additional, Fernández, Irene, additional, Leal, Lorna, additional, Benito, José Miguel, additional, Noguera-Julian, Marc, additional, Paredes, Roger, additional, Rallón, Norma, additional, Estruch, Ramón, additional, Torrents, David, additional, and García, Felipe, additional

Published
2021
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3. Association between Gut Microbiota Composition and Metabolic, Translocation, Inflammation and Immunological Parameters in Individuals Living with HIV-1

Author

Pastor Ibáñez, Roque, primary, Etcheverry, Florencia, additional, Casas, Rosa, additional, Leal, Lorna, additional, Sánchez-Palomino, Sonsoles, additional, Díez-Fuertes, Francisco, additional, Lucero, Constanza, additional, Rallón, Norma, additional, Benito, José Miguel, additional, Estruch, Ramón, additional, Torrents, David, additional, and García, Felipe, additional

Published
2021
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4. Estudio experimental de la mezcla de dos fluídos en la intersección de canales milimétricos

Author

Etcheverry, Florencia, Gomba, J., Wolluschek, C., and Cachile, Mario Andrés

Subjects
DISPERSION, MILLICHANNELS, MILICANALES
Abstract

En este trabajo se presentan los resultados del estudio experimental de las propiedades de la mezcla de dos fluídos cuando interactúan dentro de canales circulares de 4 mm de diámetro interior, cuya intersección forma ángulos de 30, 60, 90, 120 y 150º. Se diseñó, puso a punto y calibró un sistema experimental con el que se puede administrar un caudal constante en ambos canales. Las propiedades de la mezcla se estudiaron inyectando una solución coloreada por uno de ellos, y agua pura por el otro. El análisis de las imágenes adquiridas se llevó a cabo mediante un sistema de visualización desarrollado a tal fin. Se investigó el efecto del ángulo de intersección en las características del mezclado para diferentes caudales. Se encontró que el comportamiento de la mezcla es función de ambos parámetros: caudal y ángulo de intersección. Se realizaron simulaciones numéricas, cuyo modelado considera tanto efectos difusivos como convectivos, comparándose sus resultados con los experimentales In this paper the results of experimental study of the properties of the mixture of two fluids as they interact within circular channels of 4 mm internal diameter, intersecting forms angles of 30, 60, 90, 120 and 150 º are presented. We designed, tuned and calibrated an experimental system for which can a constant flow in both channels can be injected. The properties of the mixing was studied by injecting an aqueous dye solution through one of them, and pure water on the other. The analysis of the acquired images was performed by using a visualization system developed in the laboratory. The effect of the angle of intersection in the pattern of mixing for different flows has been investigated. It was found that the behavior of the mixing is a function of two parameters: flow rate and angle of intersection. Numerical simulations were performed, with a model that considers both diffusive and convective effects, and the results were compared to the experiments Fil: Etcheverry, Florencia. Universidad de Buenos Aires. Facultad de Ingeniería. Grupo de Medios Porosos (UBA-FI). Buenos Aires. Argentina Fil: Gomba, J.. Universidad Nacional Del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Instituto de Física Arroyo Seco (UNCPBA-IFAS). Buenos Aires. Argentina Buenos Aires. Argentina Fil: Wolluschek, C.. Centro Multidisciplinar de Innovación y Tecnología de Navarra (CEMITEC). Navarra. España Fil: Cachile, Mario Andrés. Universidad de Buenos Aires. Facultad de Ingeniería. Grupo de Medios Porosos (UBA-FI). Buenos Aires. Argentina

Published
2010

5. Caracterización del flujo a través de medios porosos usando el método de Lattice-Boltzmann

Author

Etcheverry, Florencia, Müller, Darío, and Cachile, Mario Andres

Subjects
purl.org/becyt/ford/1 [https], Simulación numérica, LATTICE BOLTZMANN, Ciencias Físicas, Permeabilidad, POROUS MEDIA, NUMERICAL SIMULATION, Medios Porosos, SIMULACION NUMERICA, purl.org/becyt/ford/1.3 [https], PERMEABILITY, Otras Ciencias Físicas, CIENCIAS NATURALES Y EXACTAS
Abstract

Se realizaron simulaciones del flujo a través de medios porosos 2D utilizando el método de Lattice-Boltzmann. Se estudió la relación que existe entre la porosidad y la permeabilidad, que son parámetros importantes para caracterizar un medio poroso. Se ha demostrado que el de Lattice-Boltzmann es un método adecuado para resolver la ecuación de Navier-Stokes incompresible. Dado el carácter local del método, es adecuado para condiciones de contorno de geometría compleja. Los medios porosos usados en estas simulaciones están constituidos por obstáculos de tamaño uniforme. Se encontró que el parámetro relevante que controla la permeabilidad, en estas condiciones es la distancia media entre obstáculos, lo que resulta un aporte original al tema. The flow through porous media was simulated in 2D using the Lattice-Boltzmann method.. The relation between porosity and permeability, which are important parameters to characterize porous media has been studied. The Lattice-Boltzmann method has been established to be a suitable procedure for solving incompressible Navier-Stokes equation in porous media given its local character. The media used in this work were built as a random distribution of circular obstacles with uniform diameter. It has been found that a relevant parameter that controls the permeability is the mean distance between obstacles, which is an original contribution to this subject. Fil: Etcheverry, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina Fil: Müller, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina Fil: Cachile, Mario Andres. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina

Published
2009

6. A safe, effective and affordable HIV vaccine--an urgent global need.

Author

Joseph J, Etcheverry F, Alcami J, and María GJ

Subjects
Animals, Clinical Trials as Topic, Global Health, HIV Infections epidemiology, HIV Infections immunology, HIV-1 immunology, Humans, AIDS Vaccines, HIV Infections prevention & control
Abstract

The need for a safe, effective and affordable HIV vaccine has never been greater. In 2004 almost five million people became infected with HIV. In addition, providing access to antiretrovirals in Africa remains a huge challenge. A successful vaccine against HIV will probably need to stimulate the innate immune system, generate high levels of neutralizing antibodies, induce strong cellular immune responses and mucosal immunity, and should induce broad-spectrum immunity able to cover all HIV subtypes. In this review, we describe the limitations and challenges of developing a safe and effective HIV vaccine. We also emphasize possible approaches for overcoming immune escape in HIV infection, the lessons learned from the clinical trials of HIV-1 candidate vaccines, and the most important scientific highlights of the Keystone 2005 Symposium. When an effective vaccine is eventually found, we will face the enormous task of making it accessible to those who need it most.

Published
2005

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