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2. Intubation Decision Based on Illness Severity and Mortality in COVID-19: An International Study*

Author

Chalkias, Athanasios, Huang, Yiyuan, Ismail, Anis, Pantazopoulos, Ioannis, Papagiannakis, Nikolaos, Bitterman, Brayden, Anderson, Elizabeth, Catalan, Tonimarie, Erne, Grace K., Tilley, Caroline R., Alaka, Abiola, Amadi, Kingsley M., Presswalla, Feriel, Blakely, Pennelope, Bernal-Morell, Enrique, Cebreiros López, Iria, Eugen-Olsen, Jesper, García de Guadiana Romualdo, Luis, Giamarellos-Bourboulis, Evangelos J., Loosen, Sven H., Reiser, Jochen, Tacke, Frank, Skoulakis, Anargyros, Laou, Eleni, Banerjee, Mousumi, Pop-Busui, Rodica, Hayek, Salim S., Hayek, Salim S., Blakely, Pennelope, Launius, Christopher, Berlin, Hanna, Amadi, Kingsley M., Azam, Tariq U., Shadid, Husam, Pan, Michael, O’ Hayer, Patrick, Meloche, Chelsea, Feroze, Rafey, Padalia, Kishan J., Anderson, Elizabeth, Perry, Danny, Bitar, Abbas, Kaakati, Rayan, Zhao, Lili, Zhao, Peiyao, Michaud, Erinleigh, Huang, Yiyuan, Catalan, Tonimarie, Khaleel, Ibrahim, Alaka, Abiola, Pop-Busui, Rodica, Banerjee, Mousumi, Tekumulla, Annika, Tilley, Caroline R., Tripathi, Medha, Vasbinder, Alexi, Bardwell, Alina, Presswalla, Feriel, Nelapudi, Namratha, Erne, Grace K., Chen, Jiazi, Mayette, Nathan, Sulaiman, Noor, Ismail, Anis, Pizzo, Ian, Bitterman, Brayden, Reiser, Jochen, Samelko, Beata, Hlepas, Alexander, Wang, Xuexiang, Patel, Priya, Chalkias, Athanasios, Pantazopoulos, Ioannis, Laou, Eleni, Skoulakis, Anargyros, Papagiannakis, Nikolaos, Eugen-Olsen, Jesper, Altintas, Izzet, Tingleff, Jens, Stauning, Marius, Houlind, Morten Baltzer, Lindstrøm, Mette B, Andersen, Ove, Gamst-Jensen, Hejdi, Hartmann Rasmussen, Line Jee, Rasmussen, Christian, Nehlin, Jan O., Kallemose, Thomas, Parvaiz, Imran, Loosen, Sven H., Luedde, Tom, Keitel, Verena, Giamarellos-Bourboulis, Evangelos J., Adami, Maria-Evangelia, Solomonidi, Nicky, Tsilika, Maria, Saridaki, Maria, Lekakis, Vasileios, Tacke, Frank, Tober-Lau, Pinkus, Mohr, Raphael, Kurth, Florian, Sander, Leif Erik, Jochum, Christoph, Garcia de Guadiana-Romualdo, Luis, Albaladejo-Otón, María Dolores, Rodríguez Mulero, María Dolores, Martínez, María Galindo, Olivo, Marta Hernández, Rodríguez, Valerio Campos, López, Iria Cebreiros, Carrillo, María Arnaldos, Noguera Velasco, Jose Antonio, Pascual Figal, Domingo A., Morell, Enrique Bernal, García, Antonia Alcaraz, Alcaraz García, María José, Martínez, Monica Martínez, Esteban-Torrella, Patricia, and Sancho-Rodríguez, Natalia

Published
2024
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6. qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in the emergency department: a randomized controlled trial

Author

Adami, Maria Evangelia, Kotsaki, Antigone, Antonakos, Nikolaos, Giannitsioti, Efthymia, Chalvatzis, Stamatios, Saridaki, Maria, Avgoustou, Christina, Akinosoglou, Karolina, Dakou, Konstantina, Damoraki, Georgia, Katrini, Konstantina, Koufargyris, Panagiotis, Lekakis, Vasileios, Panagaki, Antonia, Safarika, Asimina, Eugen-Olsen, Jesper, and Giamarellos-Bourboulis, Evangelos J.

Published
2024
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9. Soluble Urokinase Plasminogen Activator Receptor Is Predictive of Non-AIDS Events During Antiretroviral Therapy-mediated Viral Suppression.

Author

Hoenigl, Martin, Moser, Carlee B, Funderburg, Nicholas, Bosch, Ronald, Kantor, Amy, Zhang, Yonglong, Eugen-Olsen, Jesper, Finkelman, Malcolm, Reiser, Jochen, Landay, Alan, Moisi, Daniela, Lederman, Michael M, Gianella, Sara, and Adult Clinical Trials Group NWCS 411 study team

Subjects
Adult Clinical Trials Group NWCS 411 study team, Humans, HIV Infections, Inflammation, Viral Load, Adult, Aged, Middle Aged, Female, Male, Receptors, Urokinase Plasminogen Activator, Young Adult, Biomarkers, beta-D-glucan, lipopolysaccharide binding protein, non-AIDS mortality, suPAR, viral suppression, HIV/AIDS, Infectious Diseases, Clinical Research, 2.1 Biological and endogenous factors, Infection, Microbiology, Biological Sciences, Medical and Health Sciences
Abstract

BackgroundDespite effective antiretroviral therapy (ART), human immunodeficiency virus (HIV) infection remains associated with higher morbidity and mortality, driven, in part, by increased inflammation. Our objective was to identify associations between levels of plasma biomarkers of chronic inflammation, microbial translocation, and monocyte activation, with occurrence of non-AIDS events.MethodsParticipants (141 cases, 310 matched controls) were selected from a longitudinal observational trial; all were virally suppressed on ART at year 1 and thereafter. Soluble urokinase plasminogen activator receptor (suPAR), lipopolysaccharide binding protein (LBP), beta-D-glucan (BDG), intestinal fatty-acid binding protein, oxidized low-density lipoproteins, and soluble CD163 were measured pre-ART, after 1-year of ART, and pre-event. At each time point, conditional logistic regression analysis assessed associations of the biomarkers with events and adjusted for relevant covariates to calculate odds ratios (ORs) according to 1 interquartile range (IQR) difference.ResultsAt all time points, higher levels of suPAR were associated with increased risk of non-AIDS events (OR per 1 IQR was 1.7 before ART-initiation, OR per 1 IQR was 2.0 after 1 year of suppressive ART, and OR 2.1 pre-event). Higher levels of BDG and LBP at year 1 and pre-event (but not at baseline) were associated with increased risk of non-AIDS events. No associations were observed for other biomarkers.ConclusionsElevated levels of suPAR were strongly, consistently, and independently predictive of non-AIDS events at every measured time point. Interventions that target the suPAR pathway should be investigated to explore its role in the pathogenesis of non-AIDS-related outcomes in HIV infection.

Published
2019

11. Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Author

Kyriazopoulou, Evdoxia, Poulakou, Garyfallia, Milionis, Haralampos, Metallidis, Simeon, Adamis, Georgios, Tsiakos, Konstantinos, Fragkou, Archontoula, Rapti, Aggeliki, Damoulari, Christina, Fantoni, Massimo, Kalomenidis, Ioannis, Chrysos, Georgios, Angheben, Andrea, Kainis, Ilias, Alexiou, Zoi, Castelli, Francesco, Serino, Francesco Saverio, Tsilika, Maria, Bakakos, Petros, Nicastri, Emanuele, Tzavara, Vassiliki, Kostis, Evangelos, Dagna, Lorenzo, Koufargyris, Panagiotis, Dimakou, Katerina, Savvanis, Spyridon, Tzatzagou, Glykeria, Chini, Maria, Cavalli, Giulio, Bassetti, Matteo, Katrini, Konstantina, Kotsis, Vasileios, Tsoukalas, George, Selmi, Carlo, Bliziotis, Ioannis, Samarkos, Michael, Doumas, Michael, Ktena, Sofia, Masgala, Aikaterini, Papanikolaou, Ilias, Kosmidou, Maria, Myrodia, Dimitra-Melia, Argyraki, Aikaterini, Cardellino, Chiara Simona, Koliakou, Katerina, Katsigianni, Eleni-Ioanna, Rapti, Vassiliki, Giannitsioti, Efthymia, Cingolani, Antonella, Micha, Styliani, Akinosoglou, Karolina, Liatsis-Douvitsas, Orestis, Symbardi, Styliani, Gatselis, Nikolaos, Mouktaroudi, Maria, Ippolito, Giuseppe, Florou, Eleni, Kotsaki, Antigone, Netea, Mihai G., Eugen-Olsen, Jesper, Kyprianou, Miltiades, Panagopoulos, Periklis, Dalekos, George N., and Giamarellos-Bourboulis, Evangelos J.

Published
2021
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12. suPAR cut-offs for stratification of low, medium, and high-risk acute medical patients in the emergency department

Author

Seppälä Santeri, Andersen Andreas Peter, Nyyssönen Kristiina, Eugen-Olsen Jesper, and Hyppölä Harri

Subjects
suPAR, Laboratory marker, Emergency department, Mortality, Special situations and conditions, RC952-1245, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Soluble urokinase plasminogen activator receptor (suPAR) levels have previously been associated with readmission and mortality in acute medical patients in the ED. However, no specific cut-offs for suPAR have been tested in this population. Methods Prospective observational study of consecutively included acute medical patients. Follow-up of mortality and readmission was carried out for 30- and 90 days stratified into baseline suPAR 6 ng/ml. suPAR levels were measured using suPARnostic® Turbilatex assay on a Cobas c501 (Roche Diagnostics Ltd) analyser. Results A total of 1747 acute medical patients in the ED were included. Median age was 70 (IQR: 57–79) and 51.4% were men. Adjusted linear regression analysis showed that suPAR, independently of age, sex and C-reactive protein levels, predicted 30- and 90-day mortality (Odds ratio for doubling in suPAR 1.96 (95% confidence intervals: 1.42–2.70) Among patients with suPAR below 4 ng/ml (N = 804, 46.0%), 8 (1.0%) died within 90-day follow-up, resulting in a negative predictive value of 99.0% and a sensitivity of 94.6%. Altogether 514 (29.4%) patients had suPAR of 4–6 ng/ml, of whom 43 (8.4%) died during 90-day follow-up. Among patients with suPAR above 6 ng/ml (N = 429, 24.6%), 87 patients (20.3%) died within 90-day follow-up, resulting in a positive predictive value of 20.1% and a specificity of 78.7%. Conclusions suPAR cut-offs of below 4, between 4 and 6 and above 6 ng/ml can identify acute medical patients who have low, medium or high risk of 30- and 90-day mortality. The turbidimetric assay provides suPAR results within 30 min that may aid in the decision of discharge or admission of acute medical patients.

Published
2021
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13. Prospective and External Validation of Prognostic Machine Learning Models for Short- and Long-Term Mortality Among Acutely Admitted Patients Based on Blood Tests

Author

Jawad, Baker Nawfal, primary, Altintas, Izzet, additional, Eugen-Olsen, Jesper, additional, Niazi, Siar, additional, Mansouri, Abdullah, additional, Rasmussen, Line Jee Hartmann, additional, Schultz, Martin, additional, Iversen, Kasper Karmark, additional, Holm, Nikolaj Normann, additional, Kalle, Thomas, additional, Andersen, Ove, additional, and Nehlin, Jan O., additional

Published
2024
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15. Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

Author

Kyriazopoulou, Evdoxia, Huet, Thomas, Cavalli, Giulio, Gori, Andrea, Kyprianou, Miltiades, Pickkers, Peter, Eugen-Olsen, Jesper, Clerici, Mario, Veas, Francisco, Chatellier, Gilles, Kaplanski, Gilles, Netea, Mihai G., Pontali, Emanuele, Gattorno, Marco, Cauchois, Raphael, Kooistra, Emma, Kox, Matthijs, Bandera, Alessandra, Beaussier, Hélène, Mangioni, Davide, Dagna, Lorenzo, van der Meer, Jos W.M., Giamarellos-Bourboulis, Evangelos J., Hayem, Gilles, Volpi, Stefano, Sormani, Maria Pia, Signori, Alessio, Bozzi, Giorgio, Minoia, Francesca, Aliberti, Stefano, Grasselli, Giacomo, Alagna, Laura, Lombardi, Andrea, Ungaro, Riccardo, Agostoni, Carlo, Blasi, Francesco, Costantino, Giorgio, Fracanzani, Anna Ludovica, Montano, Nicola, Peyvandi, Flora, Sottocorno, Marcello, Muscatello, Antonio, Filocamo, Giovanni, Papadopoulos, Antonios, Mouktaroudi, Maria, Karakike, Eleni, Saridaki, Maria, Gkavogianni, Theologia, Katrini, Konstantina, Vechlidis, Nikolaos, Avgoustou, Christina, Chalvatzis, Stamatios, Marantos, Theodoros, Damoulari, Christina, Damoraki, Georgia, Ktena, Sofia, Tsilika, Maria, Koufargyris, Panagiotis, Karageorgos, Athanasios, Droggiti, Dionysia-Irene, Koliakou, Aikaterini, Poulakou, Garyfallia, Tsiakos, Konstantinos, Myrodia, Dimitra-Melia, Gravvani, Areti, Trontzas, Ioannis P., Syrigos, Konstantinos, Kalomenidis, Ioannis, Kranidioti, Eleftheria, Panagopoulos, Periklis, Petrakis, Vasileios, Metallidis, Simeon, Loli, Georgia, Tsachouridou, Olga, Dalekos, George N., Gatselis, Nikolaos, Stefos, Aggelos, Georgiadou, Sarah, Lygoura, Vassiliki, Milionis, Haralampos, Kosmidou, Maria, Papanikolaou, Ilias C., Akinosoglou, Karolina, Giannitsioti, Efthymia, Chrysos, Georgios, Mavroudis, Panagiotis, Sidiropoulou, Chrysanthi, Adamis, Georgios, Fragkou, Archontoula, Rapti, Aggeliki, Alexiou, Zoi, Symbardi, Styliani, Masgala, Aikaterini, Kostaki, Konstantina, Kostis, Evangelos, Samarkos, Michael, Bakakos, Petros, Tzavara, Vassiliki, Dimakou, Katerina, Tzatzagou, Glykeria, Chini, Maria, Kotsis, Vasileios, Tsoukalas, George, Bliziotis, Ioannis, Doumas, Michael, Argyraki, Aikaterini, Kainis, Ilias, Fantoni, Massimo, Cingolani, Antonella, Angheben, Andrea, Cardellino, Chiara Simona, Castelli, Francesco, Serino, Francesco Saverio, Nicastri, Emanuele, Ippolito, Giuseppe, Bassetti, Matteo, Selmi, Carlo, Netea, Mihai G, van der Meer, Jos W M, and Giamarellos-Bourboulis, Evangelos J

Published
2021
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16. Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis

Author

Hindy, George, Tyrrell, Daniel J., Vasbinder, Alexi, Wei, Changli, Presswalla, Feriel, Wang, Hui, Blakely, Pennelope, Ozel, Ayse Bilge, Graham, Sarah, Holton, Grace H., Dowsett, Joseph, Fahed, Akl C., Amadi, Kingsley-Michael, Erne, Grace K., Tekmulla, Annika, Ismail, Anis, Launius, Christopher, Sotoodehnia, Nona, Pankow, James S., Thorner, Lise Wegner, Erikstrup, Christian, Pedersen, Ole Birger, Banasik, Karina, Brunak, Soren, Ullum, Henrik, Eugen-Olsen, Jesper, Ostrowski, Sisse Rye, Haas, Mary E., Nielsen, Jonas B., Lotta, Luca A., Engstrom, Gunnar, Melander, Olle, Orho-Melander, Marju, Zhao, Lili, Murthy, Venkatesh L., Pinsky, David J., Willer, Cristen J., Heckbert, Susan R., Reiser, Jochen, Goldstein, Daniel R., Desch, Karl C., and Hayek, Salim S.

Subjects
Immune response -- Genetic aspects, Cell receptors -- Health aspects, Atherosclerosis -- Genetic aspects -- Development and progression -- Care and treatment, Health care industry
Abstract

People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which are strongly associated with cardiovascular outcomes. We assessed suPAR's pathogenic involvement in atherosclerosis using epidemiologic, genetic, and experimental approaches. We found serum suPAR levels to be predictive of coronary artery calcification and cardiovascular events in 5,406 participants without known coronary disease. In a genome-wide association meta-analysis including over 25,000 individuals, we identified a missense variant in the plasminogen activator, urokinase receptor (PLAUR) gene (rs4760), confirmed experimentally to lead to higher suPAR levels. Mendelian randomization analysis in the UK Biobank using rs4760 indicated a causal association between genetically predicted suPAR levels and atherosclerotic phenotypes. In an experimental model of atherosclerosis, proprotein convertase subtilisin/kexin-9 (Pcsk9) transfection in mice overexpressing suPAR ([suPAR.sup.Tg]) led to substantially increased atherosclerotic plaques with necrotic cores and macrophage infiltration compared with those in WT mice, despite similar cholesterol levels. Prior to induction of atherosclerosis, aortas of [suPAR.sup.Tg] mice excreted higher levels of CCL2 and had higher monocyte counts compared with WT aortas. Aortic and circulating [suPAR.sup.Tg] monocytes exhibited a proinflammatory profile and enhanced chemotaxis. These findings characterize suPAR as a pathogenic factor for atherosclerosis acting at least partially through modulation of monocyte function., Introduction People with chronic kidney disease (CKD) are disproportionately affected by cardiovascular disease (CVD), with two-thirds of patients having at least one form of CVD, atherosclerosis being the most common [...]

Published
2022
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17. Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 Lineage

Author

Chalkias, Athanasios, Pantazopoulos, Ioannis, Papagiannakis, Nikolaos, Skoulakis, Anargyros, Laou, Eleni, Kolonia, Konstantina, Ntalarizou, Nicoletta, Tourlakopoulos, Konstantinos, Pagonis, Athanasios, Kampolis, Christos, De Guadiana Romualdo, Luis García, Ragias, Dimitrios, Eugen-Olsen, Jesper, Gourgoulianis, Konstantinos, and Arnaoutoglou, Eleni

Published
2021
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21. Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood

Author

Matthews, Timothy, primary, Jee Hartmann Rasmussen, Line, additional, Ambler, Antony, additional, Danese, Andrea, additional, Eugen-Olsen, Jesper, additional, Fancourt, Daisy, additional, Fisher, Helen L., additional, Karmark Iversen, Kasper, additional, Schultz, Martin, additional, Sugden, Karen, additional, Williams, Benjamin, additional, Caspi, Avshalom, additional, and Moffitt, Terrie E., additional

Published
2023
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24. Overall and inter‐individual effect of four different drug classes on soluble urokinase plasminogen activator receptor in type 1 and type 2 diabetes

Author

Rotbain Curovic, Viktor, primary, Houlind, Morten B., additional, Kroonen, Marjolein Y. A. M., additional, Jongs, Niels, additional, Zobel, Emilie H., additional, Hansen, Tine W., additional, Tavenier, Juliette, additional, Eugen‐Olsen, Jesper, additional, Laverman, Gozewijn D., additional, Kooy, Adriaan, additional, Persson, Frederik, additional, Rossing, Peter, additional, and Heerspink, Hiddo J. L., additional

Published
2023
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29. Author Correction: Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Author

Kyriazopoulou, Evdoxia, Poulakou, Garyfallia, Milionis, Haralampos, Metallidis, Simeon, Adamis, Georgios, Tsiakos, Konstantinos, Fragkou, Archontoula, Rapti, Aggeliki, Damoulari, Christina, Fantoni, Massimo, Kalomenidis, Ioannis, Chrysos, Georgios, Angheben, Andrea, Kainis, Ilias, Alexiou, Zoi, Castelli, Francesco, Serino, Francesco Saverio, Tsilika, Maria, Bakakos, Petros, Nicastri, Emanuele, Tzavara, Vassiliki, Kostis, Evangelos, Dagna, Lorenzo, Koufargyris, Panagiotis, Dimakou, Katerina, Savvanis, Spyridon, Tzatzagou, Glykeria, Chini, Maria, Cavalli, Giulio, Bassetti, Matteo, Katrini, Konstantina, Kotsis, Vasileios, Tsoukalas, George, Selmi, Carlo, Bliziotis, Ioannis, Samarkos, Michael, Doumas, Michael, Ktena, Sofia, Masgala, Aikaterini, Papanikolaou, Ilias, Kosmidou, Maria, Myrodia, Dimitra-Melia, Argyraki, Aikaterini, Cardellino, Chiara Simona, Koliakou, Katerina, Katsigianni, Eleni-Ioanna, Rapti, Vassiliki, Giannitsioti, Efthymia, Cingolani, Antonella, Micha, Styliani, Akinosoglou, Karolina, Liatsis-Douvitsas, Orestis, Symbardi, Styliani, Gatselis, Nikolaos, Mouktaroudi, Maria, Ippolito, Giuseppe, Florou, Eleni, Kotsaki, Antigone, Netea, Mihai G., Eugen-Olsen, Jesper, Kyprianou, Miltiades, Panagopoulos, Periklis, Dalekos, George N., and Giamarellos-Bourboulis, Evangelos J.

Published
2021
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30. suPAR links a dysregulated immune response to tissue inflammation and sepsis-induced acute kidney injury

Author

Nusshag, Christian, primary, Wei, Changli, additional, Hahm, Eunsil, additional, Hayek, Salim S., additional, Li, Jing, additional, Samelko, Beata, additional, Rupp, Christoph, additional, Szudarek, Roman, additional, Speer, Claudius, additional, Kälble, Florian, additional, Schaier, Matthias, additional, Uhle, Florian, additional, Schmitt, Felix C.F., additional, Fiedler, Mascha O., additional, Krautkrämer, Ellen, additional, Cao, Yanxia, additional, Rodriguez, Ricardo, additional, Merle, Uta, additional, Eugen-Olsen, Jesper, additional, Zeier, Martin, additional, Weigand, Markus A., additional, Morath, Christian, additional, Brenner, Thorsten, additional, and Reiser, Jochen, additional

Published
2023
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46. Soluble Urokinase Plasminogen Activator Receptor and Venous Thromboembolism in COVID‐19

Author

Luo, Shengyuan, primary, Vasbinder, Alexi, additional, Du‐Fay‐de‐Lavallaz, Jeanne M., additional, Gomez, Joanne Michelle D., additional, Suboc, Tisha, additional, Anderson, Elizabeth, additional, Tekumulla, Annika, additional, Shadid, Husam, additional, Berlin, Hanna, additional, Pan, Michael, additional, Azam, Tariq U., additional, Khaleel, Ibrahim, additional, Padalia, Kishan, additional, Meloche, Chelsea, additional, O'Hayer, Patrick, additional, Catalan, Tonimarie, additional, Blakely, Pennelope, additional, Launius, Christopher, additional, Amadi, Kingsley‐Michael, additional, Pop‐Busui, Rodica, additional, Loosen, Sven H., additional, Chalkias, Athanasios, additional, Tacke, Frank, additional, Giamarellos‐Bourboulis, Evangelos J., additional, Altintas, Izzet, additional, Eugen‐Olsen, Jesper, additional, Williams, Kim A., additional, Volgman, Annabelle Santos, additional, Reiser, Jochen, additional, Hayek, Salim S., additional, Amadi, Kingsley, additional, O’Hayer, Patrick, additional, Feroze, Rafey, additional, Padalia, Kishan J., additional, Perry, Danny, additional, Bitar, Abbas, additional, Kaakati, Rayan, additional, Zhao, Lili, additional, Zhao, Peiyao, additional, Michaud, Erinleigh, additional, Huang, Yiyuan, additional, Catalan, Toniemarie, additional, Samelko, Beata, additional, Hlepas, Alexander, additional, Wang, Xuexiang, additional, Patel, Priya, additional, Tingleff, Jens, additional, Stauning, Marius, additional, Houlind, Morten Baltzer, additional, Lindstrøm, Mette B., additional, Andersen, Ove, additional, Gamst‐Jensen, Hejdi, additional, Rasmussen, Line Jee Hartmann, additional, Rasmussen, Christian, additional, Nehlin, Jan O., additional, Kallemose, Thomas, additional, Parvaiz, Imran, additional, Adami, Maria‐Evangelia, additional, Solomonidi, Nicky, additional, Tsilika, Maria, additional, Saridaki, Maria, additional, Lekakis, Vasileios, additional, Loosen, Sven, additional, Luedde, Tom, additional, Keitel, Verena, additional, Pantazopoulos, Ioannis, additional, Laou, Eleni, additional, Skoulakis, Anargyros, additional, Tober‐Lau, Pinkus, additional, Mohr, Raphael, additional, Kurth, Florian, additional, Sander, Leif Erik, additional, Jochum, Christoph, additional, and Koehler, Philipp, additional

Published
2022
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47. Inflammation, Hyperglycemia, and Adverse Outcomes in Individuals With Diabetes Mellitus Hospitalized for COVID-19

Author

Vasbinder, Alexi Anderson, Elizabeth Shadid, Husam Berlin, Hanna Pan, Michael Azam, Tariq U. Khaleel, Ibrahim Padalia, Kishan Meloche, Chelsea O'Hayer, Patrick Michaud, Erinleigh Catalan, Tonimarie Feroze, Rafey Blakely, Pennelope Launius, Christopher Huang, Yiyuan Zhao, Lili Ang, Lynn Mikhael, Monica Mizokami-Stout, Kara Pennathur, Subramaniam Kretzler, Matthias Loosen, Sven H. Chalkias, Athanasios Tacke, Frank Giamarellos-Bourboulis, Evangelos J. Reiser, Jochen Eugen-Olsen, Jesper Feldman, Eva L. Pop-Busui, Rodica Hayek, Salim S. Hayek, Salim S. Blakely, Pennelope Berlin, Hanna Azam, Tariq U. Shadid, Husam Pan, Michael O'Hayer, Patrick Meloche, Chelsea Feroze, Rafey Padalia, Kishan J. Anderson, Elizabeth Perry, Danny Bitar, Abbas Kaakati, Rayan Huang, Yiyuan Zhao, Lili Reiser, Jochen Samelko, Beata Hlepas, Alex Patel, Priya P. Wang, Xuexiang Eugen-Olsen, Jesper Altintas, Izzet Stauning, Marius Baltzer Houlind, Morten Lindstrøm, Mette B. Gamst-Jensen, Hejdi Hartmann, Line Jee Nehlin, Jan O. Kallemose, Thomas Parvaiz, Imran Rasmussen, Christian Andersen, Ove Tingleff, Jens Giamarellos-Bourboulis, Evangelos J. Adami, Maria-Evangelia Solomonidi, Nicky Tsilika, Maria Saridaki, Maria Lekakis, Vasileios Loosen, Sven H. Luedde, Tom Keitel, Verena Chalkias, Athanasios Arnaoutoglou, Eleni Pantazopoulos, Ioannis Laou, Eleni Kolonia, Konstantina Skoulakis, Anargyros Tacke, Frank Tober-Lau, Pinkus Mohr, Raphael Kurth, Florian Sander, Leif Erik Jochum, Christoph

Abstract

OBJECTIVE: Diabetes mellitus (DM) is a major risk factor for severe coronavirus disease 2019 (COVID-19) for reasons that are unclear. RESEARCH DESIGN AND METHODS: We leveraged the International Study of Inflammation in COVID-19 (ISIC), a multicenter observational study of 2,044 patients hospitalized with COVID-19, to characterize the impact of DM on in-hospital outcomes and assess the contribution of inflammation and hyperglycemia to the risk attributed to DM. We measured biomarkers of inflammation collected at hospital admission and collected glucose levels and insulin data throughout hospitalization. The primary outcome was the composite of in-hospital death, need for mechanical ventilation, and need for renal replacement therapy. RESULTS: Among participants (mean age 60 years, 58.2% males), those with DM (n = 686, 33.5%) had a significantly higher cumulative incidence of the primary outcome (37.8% vs. 28.6%) and higher levels of inflammatory biomarkers than those without DM. Among biomarkers, DM was only associated with higher soluble urokinase plasminogen activator receptor (suPAR) levels in multivariable analysis. Adjusting for suPAR levels abrogated the association between DM and the primary outcome (adjusted odds ratio 1.23 [95% CI 0.78, 1.37]). In mediation analysis, we estimated the proportion of the effect of DM on the primary outcome mediated by suPAR at 84.2%. Hyperglycemia and higher insulin doses were independent predictors of the primary outcome, with effect sizes unaffected by adjusting for suPAR levels. CONCLUSIONS: Our findings suggest that the association between DM and outcomes in COVID-19 is largely mediated by hyperinflammation as assessed by suPAR levels, while the impact of hyperglycemia is independent of inflammation.

Published
2022

48. Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery

Author

Chalkias, Athanasios, primary, Papagiannakis, Nikolaos, additional, Saugel, Bernd, additional, Flick, Moritz, additional, Kolonia, Konstantina, additional, Angelopoulou, Zacharoula, additional, Ragias, Dimitrios, additional, Papaspyrou, Dimitra, additional, Bouzia, Aikaterini, additional, Ntalarizou, Nicoletta, additional, Stamoulis, Konstantinos, additional, Kyriakaki, Aikaterini, additional, Eugen-Olsen, Jesper, additional, Laou, Eleni, additional, and Arnaoutoglou, Eleni, additional

Published
2022
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49. Use of the prognostic biomarker suPAR in the emergency department improves risk stratification but has no effect on mortality: a cluster-randomized clinical trial (TRIAGE III)

Author

Schultz, Martin, Rasmussen, Line Jee Hartmann, Andersen, Malene H., Stefansson, Jakob S., Falkentoft, Alexander C., Alstrup, Morten, Sandø, Andreas, Holle, Sarah L. K., Meyer, Jeppe, Törnkvist, Peter B. S., Høi-Hansen, Thomas, Kjøller, Erik, Jensen, Birgitte Nybo, Lind, Morten, Ravn, Lisbet, Kallemose, Thomas, Lange, Theis, Køber, Lars, Rasmussen, Lars Simon, Eugen-Olsen, Jesper, and Iversen, Kasper Karmark

Published
2018
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