1. Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project
- Author
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Manuela Sianes Fernández, Pablo Mesa del Castillo, Mercedes Morcillo, Isabel Labiano Bastero, Emilio Giner Serret, Javier del Pino, Cesar magro, Javier Rivera Redondo, Esperanza Naredo, Ramón Huguet Codina, María D. Fábregas, Daniel Pielfort Garrido, Beatriz González Alvarez, José M. Aramburu, Luis María Jiménez, Jose Gonzalez, Eduardo Collantes, Beatriz Yoldi, César Díaz, Enrique Júdez Navarro, Encarnación Pagán, Ivan Castellví, Javier R. Godo, José Santos-Rey, Antonio Fernández Nebro, Joan Maymó, María Luz García Vivar, Fernando Jimenez Zorzo, Raimon Sanmartí, Olga Martínez-González, Mercedes Ramentol, Claudia Murillo, Sergio Antonio Rodríguez Montero, Javier Calvo, Javier Llorca, Jordi Fiter, Chesús Beltrán Audera, Cayetano Alegre De Miquel, Gabriela Ávila, Antonio López Meseguer, Jaime Calvo Alen, Rosario García de Vicuña, Miriam García Arias, Marta Medrano, Joan M. Nolla, Trinidad Pérez Sandoval, G Salvador, Sagrario Bustabad, José Antonio Pinto-Tasende, María José Galindo, Eugenio Chamizo-Carmona, José García Torón, Ma Dolores Beteta Fernández, Ramón Valls, María A. Martín-Martínez, Pilar Morales, Francisco J. Blanco García, José M. Moreno, Teresa González Hernández, María Ángeles García Morales, Laura Cebrián Méndez, Antonio Atanes Sandoval, Isabel Rotés, Javier García González, Félix Francisco, Isabel Mateo, Indalecio Monteagudo, Maria Angeles Belmonte López, Manel Pujol, Estefanía Quesada-Masachs, Inmaculada Ros, Fernando Sánchez-Alonso, Ma José Moreno Martínez, Santos Castañeda, Ana Turrión, Juan Carlos Quevedo, Federico Díaz-González, Ruth López González, Estefanía Moreno, Esmeralda Delgado, Ana Ruibal Escribano, Carlos González-Juanatey, Sergio Ros Expósito, Pilar Font, Cristina Fernández Carballido, Francisco J. González Polo, Francisco J. López Longo, Alba Erra, Tatiana Cobo-Ibáñez, Carmen O. Sánchez González, Jesús Alberto García Vadillo, Olga Maiz, Montserrat Romera-Baurés, Gloria García Consuegra, Carmen Barbadillo, Virginia Ruiz, María Bonet, Jesús Babío Herráez, Dolores Fábregas-Canales, Antonio J. Mas, Ana Cruz, Miren Uriarte-Ecenarro, M.V. Irigoyen, Sara Marsal Barril, I. Ureña, Yolanda María León, Oscar Fontseré Patón, Alejandro Muñoz, Ángela Pecondón, Javier Bachiller, Pilar Espiño, Eva Revuelta Evrard, Miriam Amirall, Luis F. Linares, María Dolores Sánchez González, Ana Nieto, Benjamín Fernández Gutiérrez, Martina Steiner, Sara Manrique-Arija, María Luisa González Gómez, Carlos González Fernández, Inmaculada Bañegil, Dolors Grado, María J. González Fernández, Carlos Rodríguez Lozano, Cruz Fernández Espartero, Ingrid Möller, Eugenia Gonzalez de Rábago, Amalia Rueda, María P. Moreno Gil, Luis Espadaler, María Pilar Lis Bona, Inmaculada Jiménez, Julia Fernández Melón, Eugenio Giménez Ubeda, Isabel Rodríguez, C. Erausquin, Natividad Oreiro Villar, Raúl Menor Almagro, Rebeca Belmonte Gómez, Jesús Tornero-Molina, Ángel María García Aparicio, Horacio Berman, Enrique Raya, María Teresa Navío, Francisco J. Manero, Silvia Martínez Pardo, Joaquín Belzunegui, José M. Senabre, Manel Riera, Julio Sánchez, María Enriqueta Peiró, Jesús Marzo Gracía, Mónica Ibáñez, Natalia A. Rivera, J. Carlos Fernández López, Santiago Muñoz, Carmen García-Gómez, José C. Rosas, Ginés Sánchez Nievas, Elena Alonso Blanco Morales, Alberto Cantabrana, Manuel J. Moreno, Soledad Ojeda, Silvia Iniesta Escolano, Desireé Ruíz, Gema Bonilla, Antonio Zea, Carla Lannuzzelli Barroso, Pastora Granados Bautista, Luis Carreño, Francisco J. Navarro Blasco, José A. Piqueras, José A. Miranda-Filloy, Sonia Cabrera, Lydia Abasolo, Natalia Palmou, Virginia Coret Cagigal, Estefania Moreno Ruzafa, Alfonso Corrales, Silvia Sánchez Serrano, Delia Gerona, Miguel A. González-Gay, Elena Riera Alonso, Juana Sampedro Alvarez, Fernando Gamero, Azucena Hernández Sanz, Olaia Fernández Berrizbeitia, and Universidad de Cantabria
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Adult ,Male ,Risk ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Inflammatory arthritis ,030204 cardiovascular system & hematology ,Biologics ,Gastroenterology ,Arthritis, Rheumatoid ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Tocilizumab ,Internal medicine ,Internal Medicine ,medicine ,Outpatient clinic ,Humans ,Rheumatoid arthritis ,030203 arthritis & rheumatology ,Nutrition and Dietetics ,biology ,business.industry ,Abatacept ,Confounding ,Lipoprotein(a) ,Middle Aged ,medicine.disease ,Cardiovascular disease ,Rheumatology ,Biological Therapy ,Cross-Sectional Studies ,chemistry ,Immunology ,biology.protein ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Background Plasma concentrations of lipoprotein (a) (Lp(a)), a lipoprotein with atherogenic and thrombogenic properties, have a strong genetic basis, although high concentrations of Lp(a) have also been reported in the context of inflammation, as in rheumatoid arthritis (RA). Few studies evaluate the impact of biologic therapies (BT) on Lp(a) in RA, taking into account that with these new therapies a better control of inflammation is achieved. Objective The aim of the study was to evaluate the plasma concentrations of Lp(a) in Spanish RA patients on BT attending rheumatology outpatient clinics. Methods Baseline analysis of the CARdiovascular in rheuMAtology project, a 10-year prospective study, evaluating the risk of cardiovascular events in RA and other forms of inflammatory arthritis. RA patients were classified according to treatment: no biologic, anti-tumor necrosis factor, anti-interleukin-6 receptor tocilizumab (TCZ), and other biologic (rituximab or abatacept). A model of linear multivariate regression was built in which the dependent variable was Lp(a) concentration and the explanatory variable was BT. The model was adjusted for confounding factors. Results Seven hundred and seventy-five RA patients were analyzed. Plasma concentrations of total cholesterol and triglyceride were significantly higher in TCZ-treated patients. Nevertheless, no significant difference in the atherogenic index between TCZ-treated patients and patients without BT was found. After adjusting for confounding factors, patients with BT had lower concentrations of Lp(a) than those without BT; however, only TCZ-treated patients achieved statistically significant differences (?: ?0.303, 95% confidence interval: ?0.558 to ?0.047; P = .02). Conclusions RA patients treated with TCZ show lower plasma concentrations of Lp(a) compared with patients without BT. This project has been supported by an unrestricted grant from Abbvie, Spain. The design, analysis, interpretation of results, and preparation of the article have been done independently of Abbvie. Dr González-Gay's studies have been supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, and PI12/00060 and RD12/0009/0013 (RIER) from “Instituto de Salud Carlos III” (ISCIII) (Spain).
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- 2017