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443 results on '"Euromov (EuroMov)"'

1. Effects of the Competitive Season on the Isokinetic Muscle Parameters Changes in World-Class Handball Players

Author: Pierre Louis Bernard, Olivier Maurelli, Romain Dubois, Said Ahmaidi, Jacques Prioux, Adaptations Physiologiques à l'Exercice et Réadaptation à l'effort - UR UPJV 3300 (APERE), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Euromov (EuroMov), Université de Montpellier (UM), Mouvement, Équilibre, Performance, Santé (MEPS), Université de Pau et des Pays de l'Adour (UPPA), Laboratoire Mouvement Sport Santé (M2S), École normale supérieure - Cachan (ENS Cachan)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), EA 3300 APS et Conduites Motrices, Université de Picardie Jules Verne ( UPJV ), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Mouvement, Équilibre, Performance, Santé ( MEPS ), Université de Pau et des Pays de l'Adour ( UPPA ), Laboratoire Mouvement Sport Santé ( M2S ), École normale supérieure - Cachan ( ENS Cachan ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Université de Brest ( UBO ) -Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Adult, Male, medicine.medical_specialty, Competitive Behavior, Strength training, [SDV]Life Sciences [q-bio], Physical Therapy, Sports Therapy and Rehabilitation, Hamstring Muscles, 030204 cardiovascular system & hematology, Concentric, World class, Quadriceps Muscle, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, Eccentric, Humans, Orthopedics and Sports Medicine, Muscle Strength, Mathematics, [ SDV ] Life Sciences [q-bio], 030229 sport sciences, General Medicine, Lower Extremity, Torque, Hamstring, Muscle Contraction, Sports
Abstract: International audience; Maurelli, O, Bernard, PL, Dubois, R, Ahmaidi, S, and Prioux, J. Effects of the competitive season on the isokinetic muscle parameters changes in world-class handball players. J Strength Cond Res 33(10): 2778-2787, 2019-The aim of this study is to investigate the effects of the competitive season on isokinetic muscular parameters of the lower limbs in world-class handball players. Nineteen, male, world-class, handball players (age, 26.6 ± 5.4 years) participated in the study. Two bilateral isokinetic tests of knee joint flexors (H; hamstring) and extensors (Q; quadriceps) were performed in the beginning and end of the competitive season to determine the peak torque (PT), the mean power, and agonist-antagonist ratio, dominant-nondominant ratio (DNDR), and combined ratio. The results showed a significant decrease in PT values at low angular velocity (60°·s) in concentric mode for Q on dominant leg (p < 0.001). The other PT values for dominant and nondominant legs at low and high angular velocities (240°·s) and in eccentric mode (30°·s) were not significantly different for Q and H. For mean power, values did not change at 60°·s. At 240°·s, we found a significant decrease in H for dominant leg (p < 0.001) but not for nondominant leg. In eccentric mode, the results showed a significant increase on both legs (p < 0.001). For the ratios, values significantly decreased for DNDR at 60°·s for Q (p < 0.03) and for agonist/antagonist ratio at 240°·s for the dominant leg (p < 0.01). The present results highlight the importance of integrating regular strength training sessions during the competitive season in world-class handball players. Accordingly, this study should help trainers to modify their planning to maximize strength and power qualities of the lower limbs of their players in addition to avoiding injuries.
Published: 2019
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2. Cortical motor output decreases after neuromuscular fatigue induced by electrical stimulation of the plantar flexor muscles

Author: Alain Varray, Gerard Derosiere, Maria Papaiordanidou, François Alexandre, Maxime Billot, Varray, Alain, Euromov (EuroMov), Université de Montpellier (UM), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Euromov ( EuroMov ), Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), and Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM )
Subjects: Adult, Male, Recruitment, Neurophysiological, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Physiology, Stimulation, Inhibitory postsynaptic potential, Somatosensory system, Plantar flexion, Young Adult, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Medicine, Muscle, Skeletal, ComputingMilieux_MISCELLANEOUS, Electromyography, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, Motor Cortex, 030229 sport sciences, Evoked Potentials, Motor, Electric Stimulation, Peripheral, Electrophysiology, medicine.anatomical_structure, Anesthesia, Muscle Fatigue, [ SCCO.NEUR ] Cognitive science/Neuroscience, Functional near-infrared spectroscopy, business, Neuroscience, 030217 neurology & neurosurgery, Muscle Contraction, Motor cortex
Abstract: Aim Neuromuscular electrical stimulation (NMES) causes early onset of neuromuscular fatigue. Peripheral electrophysiological explorations suggest that supra-spinal alterations are involved through sensitive afferent pathways. As sensory input is projected over the primary somatosensory cortex (S1), S1 area involvement in inhibiting the central motor drive can be hypothesized. This study assessed cortical activity under a fatiguing NMES protocol at low frequency. Methods Twenty healthy males performed five NMES sequences of 17 trains over the plantar flexors (30 Hz, 4 s on/6 s off). Before and after each sequence, neuromuscular tests composed of maximal voluntary contractions (MVCs) were carried out. Cortical activity was assessed during MVCs with functional near-infrared spectroscopy over S1 and primary motor (M1) areas, through oxy- [HbO] and deoxy-haemoglobin [HbR] variation. Electrophysiological data (H-reflex during MVC, EMG activity and level of voluntary activation) were also recorded. Results MVC torque significantly decreased after the first 17 NMES trains (P
Published: 2015
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3. Using of transcranial direct-current stimulation during motor task for a better outcome

Author: Besson, Pierre, Euromov ( EuroMov ), Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Université Montpellier, Stéphane Perrey, Euromov (EuroMov), Université de Montpellier (UM), and STAR, ABES
Subjects: Conditionnement, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Répétition, Spectroscopie dans le proche infra-Rouge, Transcranial direct current stimulation (tDCS), Repetition, Priming, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Functional near infrared spectroscopy (fNIRS), Couplage fonctionnel tâche-TDCS, Optimisation, Functional targeting, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Stimulation transcranienne à courant direct (tDCS)
Abstract: Historically, humans have sought various ways to improve their daily lives. With the current technological advances, this quest is facilitated, especially in the desire to increase their cognitive and / or motor skills. Neuro imagery now makes it possible to inform the areas activated during different functional tasks. Today, it is now possible to modulate brain activity by stimulating the brain locally with weak electrical currents. One of the most common techniques for this purpose is called tDCS for transcranial direct current stimulation. The polarity of the induced current (anodal or cathodal stimulation) allows to modulate upward or downward cortico-spinal excitability by depolarizing or hyperpolarizing the membrane of the neurons, respectively. Despite a growing interest of neuromodulation techniques via tDCS, the results reported by the scientific community are relatively heterogeneous. The work initiated at the beginning of the 2000s is called into question by current results showing a rather large inter and intra variability. This stumbling block requires the development of new protocols for the application of anodal tDCS (atDCS). In this thesis, we were interested in optimizing atDCS protocols in order to increase the persistence of the induced-neuroplastic effects and to increase the behavioral performances. Two studies were carried out in order to first reveal the impact from the motor task/atDCS coupling and then to highlight the cumulative effects of multiple motor-tDCS task sessions with priming atDCS on motor performance. The first study through the use of near infrared spectroscopy allowed to report various hemodynamic changes subsequent to the motor task/atDCS coupling with respect to independent and controlled stimulation protocols. The primacy of the concomitant use of tDCS with the motor task was revealed by the slightest activation of the sensorimotor cortex during stimulation and by an increased delayed cerebral activation which could represent a neuroplastic reorganization. The second study examined the effects of repeated atDCS sessions with anoadal or cathodal tDCS priming in order to improve the learning and retention gains of the sensorimotor system. TDCS priming was more favorable for repeated atDCS sessions to generate higher motor performances contrary to sham. The cathodal polarity produced prolonged persistence. The major findings of this work allow to support the concomitant use of atDCS with the motor task. Future research is needed to study the transfer of these results into the fields of coaching and rehabilitation., De tout temps, les humains ont cherché différents moyens pour améliorer leur quotidien. Avec les avancées technologiques actuelles, cette quête s’en trouve facilitée, notamment dans la volonté d’accroître leurs capacités cognitives et/ou motrices. La neuro imagerie permet dorénavant de renseigner les aires cérébrales activées lors de différentes tâches fonctionnelles. Il est aussi possible de moduler l’activité cérébrale en stimulant localement le cerveau avec de faibles courants électriques. Une des techniques les plus répandues à cet effet est appelée tDCS pour transcranial direct current stimulation. Il s’agit en fonction de la polarité du courant induit de moduler à la hausse (stimulation anodale) ou à la baisse (stimulation cathodale) l’excitabilité cortico-spinale en dépolarisant ou en hyperpolarisant la membrane des neurones, respectivement. Malgré une démocratisation grandissante de la neuromodulation via tDCS, les résultats rapportés par la communauté scientifique sont relativement hétérogènes. Les travaux initiés au début des années 2000 sont remis en cause par des résultats actuels faisant état d’une variabilité inter et intra individuelle assez importante. Cette pierre d’achoppement nécessite de développer de nouveaux protocoles d’application de la tDCS. Dans cette thèse, nous avons étudié plusieurs modalités d’application de la tDCS afin d’accroître la persistance des effets neuroplastiques induits et d’augmenter les performances comportementales. Deux études ont été menées afin de révéler dans un premier temps les apports induits par le couplage tâche motrice-tDCS pour ensuite mettre en avant les effets cumulatifs de la répétition de sessions de tâche motrice-tDCS avec pré conditionnement sur la performance motrice. La première étude à travers l’utilisation de la spectroscopie dans le proche infrarouge a permis de rapporter des changements hémodynamiques distincts subséquents au couplage tâche motrice-tDCS par rapport à des protocoles tDCS plus conventionnels. La primauté de l’utilisation concomitante de la tDCS à la tâche motrice a été révélée par la moindre activation du cortex sensorimoteur durant la stimulation ainsi que par une activation cérébrale retardée accrue qui pourrait représenter une réorganisation neuroplastique. La seconde étude s’est intéressée aux effets de la polarité du conditionnement lors de sessions répétées avec comme objectif d’améliorer l’apprentissage et la rétention du système sensorimoteur. Le conditionnement par tDCS était plus propice lors de sessions répétées à engendrer des performances motrices supérieures contrairement à la condition sham. La polarité cathodale engendrait une persistance prolongée. Les premiers résultats de ces travaux de thèse ont permis de défendre l’usage concomitant de la tDCS avec la tâche motrice. De futures recherches sont nécessaires afin d’étudier le transfert de ces résultats dans le monde de l’entraînement ainsi que celui de la réhabilitation.
Published: 2017

4. Proximal arm non-use in post-stroke individuals

Author: Bakhti, Karima, Euromov (EuroMov), Université de Montpellier (UM), Université Montpellier, Isabelle Laffont, Denis Mottet, Euromov ( EuroMov ), and Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM )
Subjects: Analyse cinématique, Accident Vasculaire Cérébrale, Kinematic analysis, Reaching, Membre supérieur, Virtual reality, Stroke, Réalité virtuelle, Tâche d'atteinte, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Non-Use, Non-Utilisation, Upper limb, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: The use of compensatory strategies to perform activities of daily living after a stroke can reduce the upper limb recovery. In fact, post-stroke individuals with severe upper limb impairment that limits shoulder-elbow motion, have to use trunk compensation to achieve a reaching task within arms’ length, which is a form of mandatory/adaptive compensation strategy. Whereas, post-stroke individuals having adequately recovered shoulder-elbow motion, continue to use the trunk when they could use the proximal arm to achieve the reach; and this non-mandatory trunk compensation is considered maladaptive because it reflects proximal arm non-use or PANU, which is detrimental to true recovery of the paretic arm.In the first study, 45 post-stroke individuals and 45 age matched healthy controls performed a seated reaching task within arm’s length with the trunk free to move (spontaneous use) and trunk restrained (maximal use) to measure their PANU score. The analysis showed that PANU scores for the post-stroke individuals ranged between 1,9% and 40,7% with a median of 11,7%, and these PANU scores were a reliable and reproducible measure of the functional reserve of the upper limb. The PANU score threshold for clinical significance was set as 6.5% (upper limit in healthy subjects). The PANU score seems pertinent as a complement to usual clinical assessments of upper limb function and impairment (Box and Block test, Fugl-Meyer).The second study explored the applicability of the Kinect system to measure PANU scores in 19 post stroke individuals in comparison to the standard Zebris-CMS20s method. The analysis showed that the PANU score measured by the Kinect was valid and reliable, and therefore should be used as a tool to classify patients in order to propose specific upper limb rehabilitation with arm-forced use by trunk restraint or feedback.Study three was a review of innovative technologies applied to sensorimotor rehabilitation after a stroke suggesting that PANU scores could be implemented in virtual reality rehabilitation and be used as a tool to determine the efficacy of the specialised treatment.In conclusion, this thesis showed that i) objectively quantifying the proximal arm non-use (PANU score) during a reaching task using a 3D motion capture system is feasible and reliable, and ii) PANU scores are accurately determined also using a more widely available and less expensive Kinect-based motion sensor with the future aim of PANU being integrated in a Kinect-based upper limb virtual reality rehabilitation.; Après un accident vasculaire cérébral (AVC), l’utilisation de stratégies compensatoires dans les activités de la vie quotidienne peut freiner la récupération motrice du membre supérieur parétique. En effet, lors d’une tâche d’atteinte, les individus post-AVC présentant un déficit sévère limitant les mouvements épaule-coude, doivent utiliser la flexion du tronc afin de réaliser une tâche d’atteinte. Dans ce cas, il s’agit d’une compensation obligatoire-adaptative. D’autre part, certains individus post-AVC ayant suffisamment récupéré la motricité épaule-coude, continuent de solliciter une flexion du tronc, et cette compensation non-obligatoire du tronc est dite maladaptative car elle reflète la non-utilisation épaule–coude (proximal arm non-use - PANU) ayant pour effet d’entraver la récupération du bras parétique.Dans la première étude, 45 sujets post-AVC et 45 sujets contrôles sains appariés en âge ont effectué une tâche d’atteinte, le tronc libre (utilisation spontanée du bras) et le tronc auto-fixé (utilisation maximale du bras). L’analyse a montré que les scores PANU des sujets post-AVC étaient compris entre 1,9% et 40,7% avec une médiane à 11,7%. La mesure du score PANU est reproductible, valide et représente la réserve motrice épaule-coude. Le seuil significatif du PANU a été fixé à 6,5% (limite supérieure chez les sujets sains). Enfin, le score PANU est complémentaire aux tests usuels de déficience et de fonction du membre supérieur (Box and Block test, Fugl-Meyer)La deuxième étude a montré la possibilité d’utiliser un système Kinect dans l’obtention du score PANU. Des mesures ont été effectuées simultanément avec les deux systèmes (Kinect et Zebris-CMS20s) chez 19 sujets post-AVC. Cette étude a montré que le score PANU mesuré avec la Kinect pourrait être utilisé comme un outil de diagnostic qui permettrait de proposer aux sujets post-AVC une rééducation spécifique d’utilisation forcée du bras par tronc bloqué ou bien par feedback.La troisième étude est une revue de la littérature sur les technologies innovantes appliquées à la rééducation sensorimotrice post-AVC suggérant que le score PANU puisse être intégré dans un traitement rééducatif par réalité virtuelle.En conclusion, ces travaux démontrent que quantifier objectivement la non-utilisation épaule-coude (score PANU) lors d’une tâche d’atteinte est possible et reproductible. Les scores PANU peuvent être déterminés également par un système très accessible (Kinect) ce qui permettrait d’intégrer le score PANU dans un jeu de rééducation par réalité virtuelle.
Published: 2017

5. Evaluation et entrainement des capacités rythmiques par les nouvelles technologies

Author: Valentin BEGEL, Euromov (EuroMov), Université de Montpellier (UM), Université Montpellier, Simone Dalla Bella, Euromov ( EuroMov ), and Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM )
Subjects: Serious game, Musique, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Movement, Mouvement, Training, Rythme, Rhythm, Jeu sérieux, Entrainement, Music, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Humans are highly skilled in processing temporal information. This is particularly visible in our compelling sense of rhythm that manifests in our tendency to move to the beat of music. Deliberately or spontaneously, we have a tendency to clap our hands, tap our feet, or dance with music. These skills are sustained by a complex neuronal network involving auditory regions (auditory cortex, superior temporal gyrus), motor and pre-motor areas (basal ganglia, motor and pre-motor cortices), as well as motor coordination regions (e.g., the cerebellum). However, rhythm skills can be disrupted in neurological diseases like Parkinson’s disease or in neuro-developmental diseases such as dyslexia. Rhythm deficits are associated with movement and cognitive disorders. Another form of rhythm disability is beat deafness, a specific condition in which healthy individuals encounter particular difficulties in synchronizing to the beat.In this dissertation, I aim at addressing two questions. First, is it possible to extend our knowledge of inter-individual differences to rhythm skills in order to better understand mechanisms underlying rhythmic processing with a systematic tool? Second, can rhythm skills be trained in order to improve the associated motor and cognitive domains in patient populations revealing rhythm disorders?In the first part of the experimental section, I used the Battery for the Assessment of Auditory Sensorimotor and Timing Abilities (BAASTA) to systematically test and characterize subjects’ perceptual and sensorimotor timing skills. I found that the results of some tasks were highly correlated with the ones of other tasks and that, on the contrary, some tasks were totally independent from each other. This reveals that the battery can discriminate between tasks involving different and common mechanisms. In a further study, 20 healthy adults were submitted twice to BAASTA at a two-week interval. The performance in most of the tasks remained stable at retest. Finally, BAASTA was used in beat-deaf individuals. I showed that two individuals performed poorly on rhythm perception tasks, such as detecting or estimating whether a metronome is aligned to the beat of the music or not (Beat Alignment Test [BAT]). Yet, they could tap to the beat of the same stimuli. The fact that synchronization to a beat can occur in the presence of poor perception is reported for the first time in this study. On top of that, beat-deaf participants benefited similarly to controls from a regular temporal pattern (implicit timing) in a task in which they had to respond as fast as possible to a different target pitch after a sequence of standard tones.In the second part of the experimental section, I present a serious game for training rhythmic skills (Rhythm Workers) designed during the doctorate. I developed a progressive rhythm training protocol with stimuli varying in rhythmic difficulty. I conducted a proof-of-concept pilot study on 20 individuals who played the game for 15 days. Participants in the experimental groups showed high compliance and motivation in playing the game. Encouraging results were found on the evolution of their rhythmic skills, as tested with the BAT taken from BAASTA that was submitted to the participants before and after the training.In sum, in this dissertation contributed to the development of tools for the assessment and training of rhythmic skills. This enabled us to design studies to better understand rhythm processing mechanisms and to pave the way for the use of rhythm games in cognitive and motor remediation and rehabilitation.; L’être humain est doté d’une grande capacité à traiter l’information temporelle, particulièrement visible dans notre tendance à bouger avec la pulsation de la musique. Cette pulsation est appelée beat. Les capacités rythmiques sont sous-tendues par un réseau neuronal complexe, incluant les régions auditives (cortex auditif, gyrus temporal supérieur), les régions motrices et pré-motrices (les ganglions de la base, les cortex moteur et pré-moteur) et les régions de coordination motrices (par ex., le cervelet). Lorsque ces régions sont affectées par des maladies neurologiques ou développementales, les capacités rythmiques peuvent être atteintes. C’est le cas dans la maladie de Parkinson ou la dyslexie par exemple. Les déficits de rythme sont associés à des déficits moteurs et cognitifs. Une autre forme de troubles du rythme est le cas des mauvais synchroniseurs (anglais « beat deaf »), des sujets sans troubles neurologiques qui ont des difficultés à se synchroniser et/ou à percevoir le rythme.Dans cette dissertation, deux questions sont posées. Tout d’abord, est-il possible d’étendre nos connaissances des différences inter-individuelles dans les capacités de rythme avec un outil systématique, de manière à mieux comprendre les mécanismes sous-tendant le traitement du rythme ? Ensuite, les capacités de rythme peuvent-elles être entraînées, avec de potentielles applications dans l’entraînement des domaines cognitifs et moteurs associés chez les patients atteints de troubles rythmiques ?Dans la première partie de la section expérimentale, j’ai utilisé la Battery for the Assessment of Auditory Sensorimotor and Timing Abilities (BAASTA) pour évaluer systématiquement et caractériser les capacités rythmiques perceptives et sensorimotrices des individus. Les résultats obtenus à certaines tâches corrèlent hautement avec d’autres, alors que certaines tâches sont totallement indépendantes les unes des autres. Cela révèle que la batterie peut distinguer les mécanismes en commun ou différents d’une tâche à l’autre. Dans une autre étude, 20 sujets sains adultes ont été soumis à la BAASTA à deux semaines d’intervalle. La performance dans la plupart des tâches reste stable en phase de re-test. Finalement, la BAASTA a été utilisée auprès de sujets beat deaf. J’ai montré que deux individus ont des difficultés dans la perception du rythme, par exemple dans une tâche consistant à estimer si un métronome est aligné au rythme de la musique (Beat Alignment Test, BAT) alors qu’ils peuvent se synchroniser avec les mêmes stimuli. Le fait que la synchronisation au beat puisse être fonctionnelle alors que la perception est déficitaire est reporté pour la première fois. De plus, les sujets beat deaf bénéficient comme les sujets contrôles de la régularité d’une séquence (timing implicite) dans une tâche dans laquelle le but est de répondre le plus rapidement possible à une cible après une séquence de sons standards.Dans la deuxième partie de la section expérimentale, je présente un jeu sérieux pour l’entraînement des capacités de rythme (Rhythm Workers) conçu durant la thèse. J’ai développé un protocole d’entraînement des capacités de rythme progressive et conduit une étude pilote sur 20 sujets qui ont joué pendant deux semaines. Les participants ont montré une bonne adhésion au jeu et une bonne motivation à jouer. Des résultats encourageants sur l’évolution des capacités rythmiques, testés avec la version de la BAT issue de la BAASTA avant et après l’entraînement, sont présentés.En résumé, dans cette dissertation, j’ai contribué au développement d’outils pour l’évaluation et l’entraînement des capacités de rythme. Cela a permis de conduire des études pour mieux comprendre les mécanismes de traitement du rythme et d’ouvrir la voie à l’utilisation de jeux de rythme dans la réhabilitation et la remédiation cognitive et motrice.
Published: 2017

6. Effet de la stimulation rythmique audio-tactile sur les mouvements de coordination

Author: Roy , Charlotte, Euromov ( EuroMov ), Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Université Montpellier, Julien Lagarde, Simone Dalla Bella, Euromov (EuroMov), and Université de Montpellier (UM)
Subjects: Audio-Tactile, Stimulation rythmique, Cohérence temporelle, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Rhythmic stimulation, Coordination movements, Temporal coherence, Mouvement de coordination, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Our ability to merge information coming from several senses is crucial to produce and regulate our body movements. The main objective of this thesis is to study the effects of multisensory integration factors on our sensorimotor rhythmic behaviours. The multisensory integration effects on these behaviours are not well understood, being seldom studied. However, those behaviours characterize most of our daily activities such as walking, writing or doing sports. So far, multisensory processes have essentially been studied with regard to our discrimination and detection skills, highlighting the necessity of a temporal synchrony between senses for their integration. The consequences of this temporal coherence and the associated mechanisms have never been tested on sensorimotor rhythmic behaviours. Thus, we will extend their effects to these behaviours. Besides, literature shows that the movements’ features modify the processing of sensory information and can influence multisensory integration. We will test the effects of the stability of the sensorimotor system, i.e. intrinsic stability of gait, on the multisensory integration.The two main contributions of the thesis are the following ones: (1) Rhythmic behaviours obey the same principles as temporal discrimination and detection behaviours. Our results generalize the effects of temporal coherence and show for the first time a multisensory benefit on gait. (2) We suggest a novel sensorimotor compensatory assumption, highlighting the adaptive use of multisensory information by the sensorimotor system, which compensates the decrease of the intrinsic stability of the gait with a larger and/or better use of external audio-tactile information.; Notre capacité à intégrer des informations venant de nos différents sens est fondamentale pour produire et réguler les mouvements de notre corps. L’objectif général de cette thèse est d’étudier les effets des déterminants de l’intégration multisensorielle sur nos comportements sensorimoteurs rythmiques. Les effets de l’intégration multisensorielle sur ce type de comportements sont peu connus car peu étudiés. Ces comportements caractérisent pourtant la majorité de nos activités quotidiennes comme marcher, écrire ou encore lors de la pratique d’activités sportives. Jusqu’à présent les processus multisensoriels ont été étudiés principalement dans le cadre de nos capacités de discrimination et de détection, révélant notamment la nécessaire synchronie temporelle entre les modalités pour leur intégration. Les conséquences de cette cohérence temporelle et des mécanismes associés n’ont jamais été testées sur les comportements sensorimoteurs rythmiques. Nous chercherons donc à généraliser leurs effets sur ces comportements. Par ailleurs, la littérature rapporte que les caractéristiques du mouvement modifient le traitement des informations sensorielles et semblent également influencer l’intégration multisensorielle. Nous testerons ainsi l’effet des caractéristiques de stabilité du système sensorimoteur, i.e. stabilité intrinsèque de la marche, sur l’intégration multisensorielle.Les deux contributions de cette thèse sont les suivantes : (1) Les comportements rythmiques obéissent aux mêmes principes que les comportements de discrimination temporelle ou de détection. Nos résultats généralisent les effets de cohérence temporelle et montrent pour la première fois l’effet de bénéfice multisensoriel sur la marche. (2) Nous formulons une hypothèse novatrice de compensation sensorimotrice, qui souligne l’utilisation adaptée des informations multisensorielles par le système sensorimoteur. Ce dernier compense la diminution de stabilité intrinsèque de la marche par une plus grande et/ou meilleure utilisation des informations externes audio-tactiles.
Published: 2017

7. Effect of a 6-month brisk walking program on walking endurance in sedentary and physically deconditioned women aged 60 or older: A randomized trial

Author: Hubert Blain, P.L. Bernard, Jean Bousquet, Audrey Jaussent, Marie Christine Picot, Laurent Maïmoun, Tahir Masud, Olivier Coste, Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon ( MACVIA-LR ), Université Montpellier 1 ( UM1 ) -World Health Organization ( WHO/OMS ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -European Innovation Partnership on Active and Healthy Ageing Reference Site, Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Centre de Prévention et de Traitement des Maladies liées au Vieillissement, Centre Antonin Balmès, Service de médecine nucléaire [Montpellier], Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] ( PhyMedExp ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Euromov (EuroMov), Université de Montpellier (UM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), EuroMov - Digital Health in Motion (Euromov DHM), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Montpellier (UM), and CHU Montpellier
Subjects: Male, medicine.medical_specialty, Time Factors, [SDV]Life Sciences [q-bio], [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition, Physical activity, Medicine (miscellaneous), Walking, [ SDV.MHEP.GEG ] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Body Mass Index, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Walking endurance, Surveys and Questionnaires, medicine, Humans, 030212 general & internal medicine, brisk walking, Exercise, ComputingMilieux_MISCELLANEOUS, Aged, Sedentary lifestyle, Aged, 80 and over, 2. Zero hunger, Brisk walking, Nutrition and Dietetics, business.industry, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Middle Aged, ageing, Physical Endurance, Physical therapy, muscle strength, Female, Healthy ageing, women, Sedentary Behavior, Geriatrics and Gerontology, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Body mass index, human activities, 030217 neurology & neurosurgery
Abstract: International audience; BACKGROUND:Walking endurance is a predictor of healthy ageing.OBJECTIVE:To examine if a 6-month brisk walking program can increase walking endurance in sedentary and physically deconditioned older women.TRIAL DESIGN:Randomized controlled trial.SETTING:Women recruited from public meetings aimed at promoting physical activity in women aged 60 or older.SUBJECTS:121 women aged 65.7 ± 4.3 years, with sedentary lifestyle (Physical Activity Questionnaire for the Elderly score < 9.4), and a 6-minute walking distance (6MWD) below normal value based on their gender, age, and body weight, and weight.METHODS:Women were randomly assigned to a 150 min/week brisk walking program (two supervised sessions and one session on their own per week) for six months (exercisers) (n=61) or a control group with physical activity allowed freely (n=60).OUTCOME:The primary outcome was relative change in 6MWD.RESULTS:54/61 exercisers and 55/60 control subjects completed the program and data analysis was possible for 51 exercisers and 47 controls. At baseline, 6MWD was on average 23.1% and 22.5% below age-matched norms in exercisers and controls, respectively. Attendance rate for supervised sessions was 92% in exercisers. The 6MWD increased more significantly in exercisers than in controls (mean increase of 41.5% vs 11.0 %; p46%) were those with baseline lowest values of 6MWD (p=0.001) and highest values of body mass index (BMI) (p
Published: 2017
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8. Children and adults with Attention-Deficit/Hyperactivity Disorder cannot move to the beat

Author: Puyjarinet, Frédéric, Bégel, Valentin, Lopez, Régis, Dellacherie, Delphine, Dalla Bella, Simone, Euromov (EuroMov), Université de Montpellier (UM), Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 (PSITEC), Université de Lille, Psychologie : Interactions, Temps, Émotions, Cognition (PSITEC) - ULR 4072, Psychologie : Interactions, Temps, Émotions, Cognition (PSITEC) - EA 4072, Euromov [EuroMov], Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 [PSITEC], and Hôpital Gui de Chauliac [Montpellier]
Subjects: Adult, Movement, lcsh:R, lcsh:Medicine, behavioral disciplines and activities, Article, [SCCO]Cognitive science, Attention Deficit Disorder with Hyperactivity, mental disorders, Auditory Perception, Humans, lcsh:Q, lcsh:Science, Child
Abstract: Children and adults with Attention-Deficit Hyperactivity Disorder (ADHD) fail in simple tasks like telling whether two sounds have different durations, or in reproducing single durations. The deficit is linked to poor reading, attention, and language skills. Here we demonstrate that these timing distortions emerge also when tracking the beat of rhythmic sounds in perceptual and sensorimotor tasks. This contrasts with the common observation that durations are better perceived and produced when embedded in rhythmic stimuli. Children and adults with ADHD struggled when moving to the beat of rhythmic sounds, and when detecting deviations from the beat. Our findings point to failure in generating an internal beat in ADHD while listening to rhythmic sounds, a function typically associated with the basal ganglia. Rhythm-based interventions aimed at reinstating or compensating this malfunctioning circuitry may be particularly valuable in ADHD, as already shown for other neurodevelopmental disorders, such as dyslexia and Specific Language Impairment.
Published: 2017
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9. The differential effects of prolonged exercise upon executive function and cerebral oxygenation

Author: Rémi Radel, Stéphane Perrey, Karen Davranche, Gavin D. Tempest, Jeanick Brisswalter, Laboratoire de psychologie cognitive ( LPC ), Centre National de la Recherche Scientifique ( CNRS ) -Aix Marseille Université ( AMU ), Laboratory of Human Motricity, Education Sport and Health, Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Laboratoire Motricité Humaine Expertise Sport Santé ( LAMHESS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Université de Toulon ( UTLN ), Laboratoire de psychologie cognitive (LPC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), Euromov (EuroMov), Université de Montpellier (UM), Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS), and COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université de Toulon (UTLN)
Subjects: Adult, Male, Elementary cognitive task, Cognitive Neuroscience, Poison control, Experimental and Cognitive Psychology, Hypofrontality, [ SCCO.PSYC ] Cognitive science/Psychology, behavioral disciplines and activities, Prefrontal cortex, Developmental psychology, Executive Function, Young Adult, 03 medical and health sciences, Cognition, 0302 clinical medicine, Arts and Humanities (miscellaneous), Near-infrared spectroscopy, Ventilatory threshold, Reaction Time, Developmental and Educational Psychology, Humans, Exercise, Cross-Over Studies, Spectroscopy, Near-Infrared, Working memory, 030229 sport sciences, Executive functions, Neuropsychology and Physiological Psychology, Cerebrovascular Circulation, [SCCO.PSYC]Cognitive science/Psychology, Cognitive control, Response inhibition, Female, Psychology, Neuroscience, 030217 neurology & neurosurgery, psychological phenomena and processes
Abstract: International audience; The acute-exercise effects upon cognitive functions are varied and dependent upon exercise duration and intensity, and the type of cognitive tasks assessed. The hypofrontality hypothesis assumes that prolonged exercise, at physiologically challenging intensities, is detrimental to executive functions due to cerebral perturbations (indicated by reduced prefrontal activity). The present study aimed to test this hypothesis by measuring oxygenation in prefrontal and motor regions using near-infrared spectroscopy during two executive tasks (flanker task and 2-back task) performed while cycling for 60 min at a very low intensity and an intensity above the ventilatory threshold. Findings revealed that, compared to very low intensity, physiologically challenging exercise (i) shortened reaction time in the flanker task, (ii) impaired performance in the 2-back task, and (iii) initially increased oxygenation in prefrontal, but not motor regions, which then became stable in both regions over time. Therefore, during prolonged exercise, not only is the intensity of exercise assessed important, but also the nature of the cognitive processes involved in the task. In contrast to the hypofrontality hypothesis, no inverse pattern of oxygenation between prefrontal and motor regions was observed, and prefrontal oxygenation was maintained over time. The present results go against the hypofrontality hypothesis. (C) 2017 Elsevier Inc. All rights reserved.
Published: 2017
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10. Effects Of Pre-Competitive Preparation Period On The Isokinetic Muscular Characteristics In World Class Handball Players

Author: Jacques Prioux, Said Ahmaidi, Romain Dubois, Olivier Maurelli, Pierre Louis Bernard, Mouvement, Équilibre, Performance, Santé ( MEPS ), Université de Pau et des Pays de l'Adour ( UPPA ), EA 3300 APS et Conduites Motrices, Université de Picardie Jules Verne ( UPJV ), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Laboratoire Mouvement Sport Santé ( M2S ), École normale supérieure - Cachan ( ENS Cachan ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Université de Brest ( UBO ) -Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Mouvement, Équilibre, Performance, Santé (MEPS), Université de Pau et des Pays de l'Adour (UPPA), Université de Picardie Jules Verne (UPJV), Euromov (EuroMov), Université de Montpellier (UM), Laboratoire Mouvement Sport Santé (M2S), Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École normale supérieure - Cachan (ENS Cachan)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-Université de Rennes 2 (UR2), and Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Adult, Male, medicine.medical_specialty, Knee Joint, [SDV]Life Sciences [q-bio], Hamstring Muscles, Physical Therapy, Sports Therapy and Rehabilitation, 030204 cardiovascular system & hematology, Concentric, Quadriceps Muscle, World class, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Internal medicine, medicine, Humans, Injury risk, Eccentric, Orthopedics and Sports Medicine, Muscle Strength, [ SDV ] Life Sciences [q-bio], business.industry, Significant difference, 030229 sport sciences, General Medicine, Human physiology, Lower Extremity, Torque, Muscle power, Exercise Test, Cardiology, business, Hamstring, Physical Conditioning, Human, Sports
Abstract: International audience; Maurelli, O, Bernard, PL, Dubois, R, Ahmaidi, S, and Prioux, J. Effects of precompetitive preparation period on the isokinetic muscular characteristics in world class handball players. J Strength Cond Res 33(4): 1065-1074, 2019-The aim of this study was to describe the effects of 8 weeks of precompetitive preparation period (Pc2P) on the isokinetic muscular characteristics in world-class handball players. Nineteen male professional players (age, 26.6 ± 5.4 years) participated in the study. Two bilateral isokinetic tests of knee joint flexors (H; hamstring) and extensors (Q; quadriceps) were performed before and after Pc2P to determine the peak torque (PT), the mean power (MP), and the ratios (agonist-antagonist, dominant-nondominant, and combined). For the PT, Q at low angular velocity (60°·s) in concentric mode revealed no significant increase for the dominant or nondominant legs. For H, results showed a significant increase for both legs (p < 0.001). At the higher angular velocity (240°·s), Q was significantly increased for the dominant (p < 0.005) and nondominant (p < 0.002) legs and also H for both sides (p < 0.001). Eccentric mode (30°·s) showed a significant increase for dominant (p < 0.005) and nondominant (p < 0.01) legs. For MP, results showed significant increase at low angular velocity (p < 0.003) and high angular velocity (p < 0.01) for both legs. In eccentric mode, values showed a significant increase after Pc2P for dominant (p < 0.001) and nondominant (p < 0.02) legs. The ratios showed significant increase for the agonist-antagonist ratio at 60°·s for dominant leg (p < 0.003) and the nondominant leg (p < 0.01). At 240°·s, the values showed a significant difference for both side (p < 0.02). From an injury risk perspective, in addition to optimizing performance, these results demonstrated that 8 weeks of Pc2P increased the maximum strength and muscle power of international handball players, even if the ratios of the knee joint muscles did not change during this period.
Published: 2017
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11. Improvisation socio-motrice : quels impacts sur le comportement moteur ?

Author: Gueugnon , Mathieu, Euromov ( EuroMov ), Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Université Montpellier, Ludovic Marin, Benoît Bardy, Euromov (EuroMov), and Université de Montpellier (UM)
Subjects: Interaction sociale, Motor creativity, Improvisation, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Coordinations intra- et interpersonnelle, Schizophrenia, Créativité motrice, Postural coordination, Intra- and interpersonal coordination, Coordination posturale, Schizophrénie, Social interaction, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: This work investigates the socio-motor improvisation that occurs between two people. Improvisation capacities rely on our ability to interact with others by adapting our own behavioral answers to those of the other. Two parameters display these capacities: motor creativity (i.e., the richness of our movements) and interpersonal coordination. Although these two parameters are fundamental in the success of social interaction, they were never investigated jointly. This was the goal of our thesis. We aimed to explore intra- and interpersonal motor behaviors during improvisation. To do so, (i) we reviewed existing methods analyzing creativity and coordination, and proposed new ones, (ii) we measured improvisation capacities and their possible acquisition, (iii) we evaluated the influence of improvisation on postural organization of each person and (iv) we assessed the ability to improvise in presence of social deficits (associated with schizophrenia). Taken together, our results demonstrate that socio-motor improvisation is a good candidate to capture our social interactions. More precisely, we show that such capacities could discriminate healthy people from patients suffering from social deficits. Interpersonal coordination seems fundamental since it improves improvisation capacities and postural stability during social interaction. These results are discussed in the conceptual framework of the dynamical approach to movement coordination. We propose a simplified model of socio-motor improvisation including creativity and coordination. Finally, our conclusions offer new perspectives for the understanding and the improvement of social interactions, in presence or not of social disorders.; Ce travail de thèse étudie l’improvisation socio-motrice, entre deux personnes. Nos capacités d’improvisation reflètent notre faculté à interagir avec autrui en adaptant nos réponses comportementales à celles de l’autre. Deux paramètres rendent compte de ces capacités : la créativité motrice, c’est-à-dire la richesse des mouvements, et la coordination interpersonnelle. Bien que fondamentaux dans le succès de nos interactions sociales, leur investigation conjointe, jamais réalisée, semble nécessaire. Le but de cette thèse était donc d’investiguer les comportements moteurs inter- et intra-personnels en situation d’improvisation. Pour cela, nous avons d’abord : (i) recueilli et défini les méthodes d’analyse de la créativité motrice et de la coordination, (ii) analysé les capacités d’improvisation et leur acquisition, (iii) mesuré l’effet de l’improvisation sur l’organisation posturale de chacun, et finalement (iv) évalué les capacités d’improvisation en présence d’un déficit d’interaction sociale (associé à la schizophrénie). Pris ensemble, nos résultats indiquent que l’improvisation socio-motrice est un bon témoin de nos interactions sociales. Nous montrons précisément que les capacités d’improvisation permettent de discriminer un individu sain d’un individu souffrant de déficit social. La coordination interpersonnelle semble jouer un rôle fondamental, aussi bien dans l’acquisition de l’improvisation que dans la stabilité posturale qui la sous-tend. Ces résultats sont discutés à travers l’approche des patrons dynamiques de coordination. Nous proposons un modèle simplifié de l’improvisation intégrant la coordination et la créativité. Nos conclusions offrent des perspectives permettant de mieux comprendre et améliorer nos interactions sociales, en présence ou non de désordres sociaux.
Published: 2016

12. Living Lab MACVIA Handicap

Author: R Morales, Jérôme Froger, Jacques Morel, Olivier Jonquet, Christian Hérisson, Bernard Combe, Arnaud Dupeyron, O Hantkié, F Nouvel, L. Landreau, Denis Mottet, Philippe Fraisse, Jean Bousquet, Isabelle Laffont, E. Galano, Karine Patte, V Cros, P Nicolas, A. Gelis, P Kouyoumdjian, E. Viollet, M Fouletier, Bertrand Coulet, P Coignard, David Guiraud, Gérard Dray, Jacques Mercier, Benoît G. Bardy, J. Pelissier, F. Coroian, M Enjalbert, Jérôme Cottalorda, C Leblond, C Fattal, Hubert Blain, Pierre Labauge, B Soua, Christine Azevedo, L Schifano, François Rivier, M. Porte, H.-Y. Bonnin, E Pastor, C. Jourdan, Rodolphe Bourret, K. Bakhti, I. Tavares, William Camu, V. Carre, Institut fédératif de recherche sur le handicap / Réseau fédératif de recherche sur le handicap ( IFRH / RFRH ), Université Panthéon-Sorbonne ( UP1 ) -Université Montpellier 1 ( UM1 ) -Institut national d'études démographiques ( INED ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Bordeaux Segalen - Bordeaux 2-Université de Lille, Sciences et Technologies-Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université de Bourgogne ( UB ) -Université de Valenciennes et du Hainaut-Cambresis ( UVHC ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Conservatoire National des Arts et Métiers [CNAM] ( CNAM ) -INST GARCHES-CTNERHI-Université de Lille, Sciences Humaines et Sociales-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lille, Droit et Santé-Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Laboratoire de Spectrométrie de Masse et de Chimie Laser ( LSMCL ), Université Paul Verlaine - Metz ( UPVM ), Laboratoire composants et systèmes pour télécommunications ( LCST ), Institut National des Sciences Appliquées ( INSA ), Unité mixte de physique CNRS/Thalès ( UMP CNRS/THALES ), THALES-Centre National de la Recherche Scientifique ( CNRS ), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] ( PhyMedExp ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Computer Sciences, Universidad de Málaga [Málaga], Hôpital Universitaire Carémeau [Nîmes], Centre de résonance magnétique biologique et médicale ( CRMBM ), Aix Marseille Université ( AMU ) -Assistance Publique - Hôpitaux de Marseille ( APHM ) -Centre National de la Recherche Scientifique ( CNRS ), Service de chirurgie pédiatrique [Hôpital Lapeyronie-Arnaud de Villeneuve], Hôpital Lapeyronie [Montpellier] ( CHU ), Institut de Médecine Tropicale du Service de Santé des Armées ( IMTSSA ), Service de Santé des Armées, Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de KERPAPE [Ploemeur] ( CMRRF ), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape, Departamento de Química Física, Tenerife, Universidad de la Laguna, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon ( MACVIA-LR ), Université Montpellier 1 ( UM1 ) -World Health Organization ( WHO/OMS ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -European Innovation Partnership on Active and Healthy Ageing Reference Site, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Médecine Physique et de Réadaptation, Centre Hospitalier Universitaire de Nîmes ( CHU de Nîmes ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Euromov (EuroMov), Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Centre de Rééducation et de Réadaptation Fonctionnelles de La Chataigneraie [Menucourt] (CRRF), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Unité mixte de physique CNRS/Thales (UMPhy CNRS/THALES), Centre National de la Recherche Scientifique (CNRS)-THALES, Institut Marin St Pierre, IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Laboratoire de Biochimie [CHRU Nîmes], Hôpital Lapeyronie [Montpellier] (CHU), Laboratoire de Mécanique et Génie Civil (LMGC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Bourgès - Oc Santé [Castelnau], Oc Santé [Montpellier], Institut de Médecine Tropicale du Service de Santé des Armées (IMTSSA), Centre Bouffard-Vercelli, Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de KERPAPE [Ploemeur] (CMRRF), Association ADAGES - Les Fontaines d'Ô, Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Centre communale d'action sociale [Lattes] (CCAS de Lattes), Mairie de Lattes, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), THALES [France]-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Montpellier (INM), Biomécanique des Interactions et de l'Organisation des Tissus et des Cellules (BIOTIC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM)
Subjects: Gerontology, Patient care team, [ SDV ] Life Sciences [q-bio], business.industry, [SDV]Life Sciences [q-bio], Public-Private Sector Partnership, General Medicine, 03 medical and health sciences, Health personnel, 0302 clinical medicine, Chronic disease, Living lab, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Medicine, Frail elderly, 030212 general & internal medicine, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, ComputingMilieux_MISCELLANEOUS
Abstract: La Presse Medicale - In Press.Proof corrected by the author Available online since vendredi 16 octobre 2015
Published: 2015
Full Text: View/download PDF

13. Le site de référence du Partenariat européen d’innovation pour un vieillissement actif et en bonne santé MACVIA-LR (contre les maladies chroniques pour un vieillissement en bonne santé en Languedoc-Roussillon)

Author: Miren David, Ariane Sultan, Guillaume Pandraud, Benoît G. Bardy, Jacques Morel, Giacomo Cavalli, Sylvain Jacquemin, Christine Rolland, Cyril Breuker, Philippe Boulet, Gregoire Mercier, Stéphane Bouly, Valérie Bruguière, Gwen Mathieu, Marc Meissonnier, Hervé Tassery, Vincent Marmelat, Michel Dauzat, Hubert Blain, Gérard Dray, Cyril Laurent, Christine Viarouge-Reunier, Marie Virginie Calmels, François Rivier, Gérard Dupeyron, Gérard Bourrel, Jacquie Berthe, Philippe Domy, Béatrice Lognos, Martine Aoustin, Davide Caimmi, Michel Kaczorek, Mélanie Badin, Pierre Nicolas, Alain Le Quellec, Sylvie Boichot, Vincent Le Moing, C. Boegner, Jérôme Fernandes, Michel Amouyal, Matthieu Desplan, Jean Paul Cristol, T. Camuzat, Karima Bakhti, Jean Michel Verdier, Paule Adnet, Christophe Jorgensen, Denis Sablot, Jean Ribstein, Henriette Dhivert-Donnadieu, Céline Vergne-Richard, Emilie Porte, Christine Azevedo, Isabelle Quéré, Dominique Jakovenko, Marion Gellerat-Rogier, Michel Tanfin, Karen Ritchie, Flavia Oana Coroian, Bernard Guillot, Fabrice Nouvel, J. Pelissier, Anna Bedbrook, Daniel Laune, Jean-Luc Bourrain, Yves Marie Pers, Jean Luc Savy, Chantal Marion, Cherif Heroum, Marianna Danko, Grégoire Vergotte, Françoise Radier-Pontal, Jean Luc Pasquié, Olivier Bénézet, Bernard Combe, Sylvain Richard, Liliane Landreau, Valérie Cros, Isabelle Rédini-Martinez, Emilie Viollet, David Guiraud, François Roubille, Jérôme Froger, Bertrand Coulet, Laurent Journot, Marie Suzanne Léglise, Sylvie Arnavieilhe, Isabel Tavares, Samir Jaber, Olivier Jonquet, David Morquin, Philippe Van de Perre, Roland Sicard, Raphaël Chiron, Vincent Tribout, Pierre Senesse, Xavier Quantin, Jacques Touchon, Kevin Mandrick, Alain Uziel, Vincent Bouix, Marie Christine Picot, Philippe Augé, Martine Lapierre, Antoine Avignon, Eric Pastor, Pascal Demoly, Kjerstin Torre, Jacques Mercier, Jean-Marie Robine, Dominique Larrey, D. J. Costa, Grégory Ninot, Laurent Schifano, Baya Soua, Anne Wojtusciszyn, Jean-Christophe Gris, Didier Delignières, Florence Gressard, Marie Pierre Pasdelou, Fabienne Portejoie, Michel Mondain, Philippe Nérin, Olivier Hantkié, Xavier Bobia, Delphine Paccard, Pierre Géraud Claret, Maxime Villiet, Jacques Burille, Christian Hérisson, Guillaume Tallon, V. Attalin, Jean Emmanuel de la Coussaye, William Camu, Didier Hoa, Chokri Boubakri, Jacques Reynes, Michel Enjalbert, Pascal Kouyoumdjian, Anthony Gellis, Jean Marc Lussert, Jean Philippe Pin, Christian Bourquin, Jean-Marc Lemaitre, Rodolphe Bourret, Isabelle Laffont, Claudine Berr, Marie Christine Courrouy-Michel, Nicolas Giraudeau, Trias Asteriou, Catherine Leblond, Cyril Meunier, Sylvain Lehmann, M. Nogues, Denise Strubel, Raul Punta-Morales, Alain Makinson, Jacques Bringer, Stéphane Perrey, Nathalie Pinto, Yannick Stephan, Charles Fattal, Jean Marc Davy, Arnaud Bourdin, Emilie Royère, Arnaud Dupeyron, Claire Daien, François Vialla, Frédéric Viart, Joël Bockaert, Arnaud Yves Goucham, Pierre Aubas, Huei Yune Bonnin, Fares Gouzi, Véronique Carre, Nicolas Best, Jean Pierre Riso, Jérome Cottalorda, Max Villain, Philippe Dauenhauer, Patrick Messner, Amélie Matheron, Claude Jeandel, Roxana Taddei-Ologeanu, Bernard Alomène, Sylvie Albert, Stéphane Cade, Gérard Canovas, Pauline Coignard, Karine Patte, Sofiane Ramdani, Frédéric Abecassis, Maurice Hayot, Marc Ychou, Anne Laure Coupet, Nathalie Raffort, D. Heve, Philippe Gabrion, Pierre Mares, Pierre Labauge, Marie Pierre Battesti, Denis Mottet, Philippe Fraisse, Jean Bousquet, Jean Louis Pujol, Emilie Galano, Pierre Fesler, Vincent Dufour, Gregory Baptista, Pierre Louis Bernard, Mireille Fouletier, Pierre Dujol, Xavier Vasquez, Jean Paul Ortiz, Pierre Martin-Gousset, Philippe Courtet, Oude Engberink, Valérie Handweiler, S. Granier, Laurence Vian, Françoise Leclercq, Frédéric Cuisinier, Pierre Costa, Guillaume Cayla, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Département d'anesthésie-réanimation[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier], Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Department of Geriatrics - Efficiency and Deficiency Laboratory, Hadassah Hebrew University Medical Center [Jerusalem], IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT), Département de Biostatistiques, Agence Régionale de Santé Languedoc Roussillon (ARS), Institut de Recherche en Infectiologie de Montpellier (IRIM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Roche Pharma Research and Early Development [Basel] (pRED), F. Hoffmann-La Roche [Basel], Service de gynécologie-obstétrique, Mécanismes adaptatifs : des organismes aux communautés (MAOAC), Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Muséum national d'Histoire naturelle (MNHN), Laboratoire de Géochimie Isotopique Environnementale (GIS) / Université de Nîmes (GIS), Université de Nîmes (UNIMES)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Genre (LARHRA GENRE), LAboratoire de Recherche Historique Rhône-Alpes - UMR5190 (LARHRA), Centre National de la Recherche Scientifique (CNRS)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Grenoble Alpes (UGA), Département de Médecine générale, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Département de médecine générale, Université de Montpellier (UM), Euromov (EuroMov), Centre Européen de Réalité Virtuelle (CERV), École Nationale d'Ingénieurs de Brest (ENIB), Laboratoire de Mathématiques Blaise Pascal (LMBP), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Pathologies du système nerveux : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), CERFRANCE Nord Est - Ile de France, Réseau de Vigilance en Dermato-Allergologie - Groupe d'Etudes et de Recherches en DERmato-Allergologie (Revidal-Gerda), Réseau de Vigilance en Dermato-Allergologie (Revidal), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de KERPAPE [Ploemeur] (CMRRF), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape, Laboratoire de Bioingénierie et NanoSciences (LBN), Institut de Génétique Moléculaire de Montpellier (IGMM), Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UM3)-Université de Montpellier (UM), Laboratory of Cardio-Vascular Physiology (LCVP), Université Montpellier 1 (UM1), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Rééducation et Réadaptation Neuro Orthopédique [Nîmes] (Pôle NACRRE), Hôpital Universitaire Carémeau [Nîmes], Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Oc Santé Montpellier, Artificial movement and gait restoration (DEMAR), Unité de Rééducation Neurologique, Centre Hélio-Marin CHU Nîmes, Department de Dermatologie, Médecine physique et de réadaptation, Hôpital Lapeyronie [Montpellier] (CHU), Institut de Génomique Fonctionnelle - Montpellier GenomiX (IGF MGX), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie Orthopédique, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Centre Bouffard-Vercelli, Laboratoire de Mécanique et Technologie (LMT), École normale supérieure - Cachan (ENS Cachan)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Plateforme de Protéomique Clinique, CHU Saint-Eloi, Recherches Translationnelles sur le VIH et les maladies infectieuses (TransVIHMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Universtié Yaoundé 1 [Cameroun]-Université de Montpellier (UM), Département Conception et conduite des véhicules Aéronautiques et Spatiaux (DCAS), Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), Lab-STICC_TB_CID_TOMS, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de recherche souterrain de Meuse/Haute-Marne, Agence Nationale de gestion des Déchets Radioactifs, Aix-Marseille Université - Faculté des Sciences du Sport (AMU FSS), Aix Marseille Université (AMU), HORIBA Medical (HORIBA ABX SAS), HORIBA Scientific [France], Unité Mathématique, Informatique et Génome (MIG), Institut National de la Recherche Agronomique (INRA), Interactions, Corpus, Apprentissages, Représentations (ICAR), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-INRP-Ecole Normale Supérieure Lettres et Sciences Humaines-Centre National de la Recherche Scientifique (CNRS), Unité clinique d'Immuno-Rhumatologie & Thérapeutique des maladies ostéo-articulaires, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS), UNICANCER - Institut régional du Cancer [Montpellier] (ICM), CRLCC Val d'Aurelle - Paul Lamarque, Biocommunication en Cardio-Métabolique (BC2M), Neuropsychiatrie : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Département d'oncologie médicale et digestive, Centre de cancérologie Val d'Aurelle, Complexité, Innovation, Activités Motrices et Sportives (CIAMS), Université d'Orléans (UO)-Université Paris-Sud - Paris 11 (UP11), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie et thérapie des déficits sensoriels et moteurs, Université Montpellier 2 - Sciences et Techniques (UM2)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche et de Diagnostic sur le Sida (CeDreS), CHU Treichville, Interaction entre Systèmes Protéiques et Différenciation dans la Cellule Tumorale (ISPDCT), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Dynamiques du droit (DD), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Centre National de la Recherche Scientifique (CNRS), Centre de pharmacologie et innovation dans le diabète (CPID), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre National de la Recherche Scientifique (CNRS), Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Gui de Chauliac, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] ( PhyMedExp ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), IMT - Mines Alès Ecole Mines - Télécom ( IMT - MINES ALES ), Agence Régionale de Santé Languedoc Roussillon ( ARS ), Institut de Recherche en Infectiologie de Montpellier ( IRIM ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ), Roche Pharma Research and Early Development [Basel] ( pRED ), Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ), Mécanismes adaptatifs : des organismes aux communautés ( MAOAC ), Muséum National d'Histoire Naturelle ( MNHN ) -Collège de France ( CdF ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Géochimie Isotopique Environnementale (GIS) / Université de Nîmes ( GIS ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Nîmes ( UNIMES ), Institut de recherche en cancérologie de Montpellier ( IRCM ), Université Montpellier 1 ( UM1 ) -CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon ( MACVIA-LR ), Université Montpellier 1 ( UM1 ) -World Health Organization ( WHO/OMS ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -European Innovation Partnership on Active and Healthy Ageing Reference Site, Agence Nationale de Sécurité Sanitaire, de l'Alimentation, de l'environnement et du Travail ( ANSES ), ANSES, Genre ( LARHRA GENRE ), LAboratoire de Recherche Historique Rhône-Alpes - UMR5190 ( LARHRA ), Centre National de la Recherche Scientifique ( CNRS ) -Université Jean Moulin - Lyon III-Université Lumière - Lyon 2 ( UL2 ) -École normale supérieure - Lyon ( ENS Lyon ) -Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Jean Moulin - Lyon III-Université Lumière - Lyon 2 ( UL2 ) -École normale supérieure - Lyon ( ENS Lyon ) -Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Université Grenoble Alpes ( UGA ), Université Montpellier 1 ( UM1 ), Artificial movement and gait restoration ( DEMAR ), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier ( LIRMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Université de Montpellier ( UM ), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Centre Européen de Réalité Virtuelle ( CERV ), École Nationale d'Ingénieurs de Brest ( ENIB ), Laboratoire de Mathématiques Blaise Pascal ( LMBP ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Centre National de la Recherche Scientifique ( CNRS ), Université Montpellier 1 ( UM1 ) -IFR76-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Génomique Fonctionnelle ( IGF ), Centre National de la Recherche Scientifique ( CNRS ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Réseau de Vigilance en Dermato-Allergologie - Groupe d'Etudes et de Recherches en DERmato-Allergologie ( Revidal-Gerda ), Réseau de Vigilance en Dermato-Allergologie ( Revidal ), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de KERPAPE [Ploemeur] ( CMRRF ), Laboratoire de Bioingénierie et NanoScience-UM, Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Institut de Génétique Moléculaire de Montpellier ( IGMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Dynamique des capacités humaines et des conduites de santé ( EPSYLON ), Université Paul-Valéry - Montpellier 3 ( UM3 ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Laboratory of Cardio-Vascular Physiology ( LCVP ), Institut Pierre Louis d'Epidémiologie et de Santé Publique ( iPLESP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Département de Rééducation et Réadaptation Neuro Orthopédique [Nîmes] ( Pôle NACRRE ), Centre Mutualiste de Réeducation Neurologique Propara ( PROPARA ), Hôpital Lapeyronie [Montpellier] ( CHU ), Institut de Génomique Fonctionnelle - Montpellier GenomiX ( IGF MGX ), Laboratoire de Mécanique et Technologie ( LMT ), École normale supérieure - Cachan ( ENS Cachan ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), CHU Saint-Eloi-Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Recherches Translationnelles sur le VIH et les maladies infectieuses ( TransVIHMI ), Université Montpellier 1 ( UM1 ) -Université Cheikh Anta Diop ( UCAD ) -Universtié Yaoundé 1 (Cameroun)-Université de Montpellier ( UM ), Département Conception et conduite des véhicules Aéronautiques et Spatiaux ( DCAS ), Institut Supérieur de l'Aéronautique et de l'Espace ( ISAE-SUPAERO ), Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance ( Lab-STICC ), École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ) -École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Aix-Marseille Université - Faculté des Sciences du Sport ( AMU FSS ), Aix Marseille Université ( AMU ), HORIBA Medical ( HORIBA ABX SAS ), Unité Mathématique, Informatique et Génome ( MIG ), Institut National de la Recherche Agronomique ( INRA ), Interactions, Corpus, Apprentissages, Représentations ( ICAR ), École normale supérieure - Lyon ( ENS Lyon ) -Université Lumière - Lyon 2 ( UL2 ) -INRP-Ecole Normale Supérieure Lettres et Sciences Humaines-Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Lapeyronie, Institut de Chimie des Substances Naturelles ( ICSN ), Centre National de la Recherche Scientifique ( CNRS ), UNICANCER - Institut régional du Cancer [Montpellier] ( ICM ), Efficience Déficience Motrice [Montpellier] ( EDM ), Centre de pharmacologie et innovation dans le diabète ( CPID ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Centre National de la Recherche Scientifique ( CNRS ), Complexité, Innovation, Activités Motrices et Sportives ( CIAMS ), Université Paris-Sud - Paris 11 ( UP11 ) -Université d'Orléans ( UO ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Montpellier 2 - Sciences et Techniques ( UM2 ) -IFR76-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de recherche et de Diagnostic sur le Sida ( CeDreS ), Interaction entre Systèmes Protéiques et Différenciation dans la Cellule Tumorale ( ISPDCT ), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique ( CNRS ), Dynamiques du droit ( DD ), Centre National de la Recherche Scientifique ( CNRS ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Agence Régionale de la Santé (ARS), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Pierre Mendès France - Grenoble 2 (UPMF)-École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Oc Santé [Montpellier], Interactive Digital Humans (IDH), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Service de Rhumatologie [CHRU Montpellier], École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-INRP-Ecole Normale Supérieure Lettres et Sciences Humaines (ENS LSH)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut du Cancer de Montpellier (ICM), Université Paris-Sud - Paris 11 (UP11)-Université d'Orléans (UO), Centre de recherche et de Diagnostic sur le Sida [Abidjan, Côte d'Ivoire] (CeDreS), Centre Hospitalier Universitaire de Treichville [Abidjan, Côte d'Ivoire] (CHU de Treichville), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 1 (UM1), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1), Muséum national d'Histoire naturelle (MNHN)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), and CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Aging, [ SDV ] Life Sciences [q-bio], business.industry, [SDV]Life Sciences [q-bio], General Medicine, MESH: Accidental Falls, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Medicine, 030211 gastroenterology & hepatology, Accidental Falls, MESH: Aging, 030212 general & internal medicine, business, Humanities, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Le site de référence du Partenariat européen d'innovation pour un vieillissement actif et en bonne santé MACVIA-LR (contre les maladies chroniques pour un vieillissement en bonne santé en Languedoc-Roussillon)
Published: 2015
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14. Pharmacoepidemiology studies: what levels of evidence and how can they be reached?

Author: Damien Chopy, Caroline Vigneau, Claudine Sapède, Joëlle Micallef, Maryse Lapeyre-Mestre, Muriel Malbezin, François Gueyffier, Yannick Plétan, L. Lacoin, Nicholas Moore, David Evans, Gérard Pons, Dana Morlet-Vigier, Pascal Bilbault, Patrice Verpillat, Emmanuel Oger, Patrick Blin, Sophie Muller, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de pharmacologie médicale et clinique, CHU Toulouse [Toulouse], Laboratoire Roche [Boulogne-Billancourt], Department of Pharmacology, Xinjiang Medical University, Laboratoire de Pharmacologie Expérimentale, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Département Hospitalo-Universitaire de Pharmacologie de Bordeaux, CHU de Bordeaux Pellegrin [Bordeaux]-Université Victor Segalen - Bordeaux 2-CHU de Bordeaux Pellegrin [Bordeaux]-Université Victor Segalen - Bordeaux 2, Hôpital de Strasbourg, CHU Strasbourg, Département Hospitalo-Universitaire de Pharmacologie de Bordeaux, CHU de Bordeaux Pellegrin [Bordeaux]-Université Victor Segalen - Bordeaux 2, Neuro-Immunologie Virale, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Laboratoire pharmaceutique Lilly France [Neuilly-sur-Seine], Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Haute Autorité de Santé [Saint-Denis La Plaine] (HAS), Janssen-Cilag [Issy-les-Moulineaux], Euromov (EuroMov), Université de Montpellier (UM), IMS Health [Puteaux], Laboratoire GlaxoSmithKline [ Marly-le-Roi], CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pharmacologie [Rennes], CHU Pontchaillou [Rennes], Epilepsies de l'Enfant et Plasticité Cérébrale (U1129), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurologie et thérapeutique expérimentale, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR70-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Pharmacologie Clinique [CHU Toulouse], Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Épidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps, Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Biométrie et Biologie Evolutive ( LBBE ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique ( Inria ) -Centre National de la Recherche Scientifique ( CNRS ), Haute Autorité de Santé [Saint-Denis La Plaine] ( HAS ), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Pharmacologie, Epilepsies de l'Enfant et Plasticité Cérébrale ( U1129 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris Descartes - Paris 5 ( UPD5 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR70-Université Pierre et Marie Curie - Paris 6 ( UPMC ), Institut de Génétique et Développement de Rennes ( IGDR ), Université de Rennes 1 ( UR1 ), and Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Drug-Related Side Effects and Adverse Reactions, [SDV]Life Sciences [q-bio], Population, Scientific modelling, 030226 pharmacology & pharmacy, Toxicology, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Causation, education, Research question, education.field_of_study, Actuarial science, [ SDV ] Life Sciences [q-bio], business.industry, Pharmacoepidemiology, Evidence-based medicine, 3. Good health, Identification (information), Treatment Outcome, Epidemiologic Research Design, Evidence-Based Practice, Patient Safety, Descriptive research, business
Abstract: International audience; In pharmacoepidemiology studies, the nature of the research question will dictate the choice of methodological approach and the conditions for optimizing the level of evidence. Thus, to document the treated population and the modes of use of a new drug in real-life prescribing conditions, a descriptive approach through cross-sectional or longitudinal studies conducted on databases, or else ad-hoc studies, will be preferred. On the other hand, evaluation of the real-life "effectiveness" of a new drug will be based on cohort, case-control or scientific modeling, depending on the drug and the disease of interest. For questions involving drug risks and safety, it is the adverse effects profile that will guide the choice of study design, both for identification of the effect (signal) and assessment of causation. In all cases, in the post-marketing authorization (MA) setting, the evidence acquired in pre-MA studies serves as the basis for generating hypotheses. Whatever the research question and the method chosen to address it, the potential biases and their impact on the results need to be identified. In certain cases, a combination of several complementary approaches may prove preferable to a single study.
Published: 2013
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15. [How to define old age: successful aging and/or longevity]

Author: Berr, Claudine, Balard, Frédéric, Blain, Hubert, Robine, JM, Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centres Mémoire de Ressources et de Recherche Montpellier (CMRR), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier], Fondation Nationale de Gérontologie (FNG), Institution de Gérontologie, Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Département de Gériatrie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Euromov (EuroMov), Université de Montpellier (UM), CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neuropsychiatrie : recherche épidémiologique et clinique, Université Montpellier 1 ( UM1 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Centres Mémoire de Ressources et de Recherche Montpellier ( CMRR ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Gui de Chauliac, Fondation Nationale de Gérontologie ( FNG ), Mécanismes moléculaires dans les démences neurodégénératives ( MMDN ), École pratique des hautes études ( EPHE ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), CERMES3 - Centre de recherche, médecine, sciences, santé, santé mentale, société ( CERMES3 - UM 7 (UMR 8211 / U988) ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ) -École des hautes études en sciences sociales ( EHESS ), and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-École des hautes études en sciences sociales (EHESS)
Subjects: Aged, 80 and over, Male, Aging, Longevity, Population Dynamics, Role, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Health Promotion, Middle Aged, United States, Europe, Age Distribution, Life Expectancy, Japan, Activities of Daily Living, Humans, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Disease Susceptibility, France, Sex Distribution, Aged, Forecasting
Abstract: International audience; In half a century, the number of nonagenarians and/or centenarians has dramatically increased, particularly due to the increase in life expectancy at old age. However, successful aging is more important than longevity. All along their life, people can act to preserve their health, their physical and mental abilities as well as their autonomy. This requires a healthy diet, having physical and intellectual appropriate activities and a right use of medical care. Finally, maintaining a social role and a raison d'être in old age are also major factors in successful aging.
Published: 2012
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16. People post-stroke perceive movement fluency in virtual reality

Author: Liesjet van Dokkum, J. Metrot, Isabelle Hauret, Isabelle Laffont, Denis Mottet, Agnès Roby-Brami, Huei-Yune Bonnin-Koang, Euromov (EuroMov), Université de Montpellier (UM), Neurophysique et physiologie du système moteur (NPSM), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Service de médecine physique et de réadaptation, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Raymond Poincaré [AP-HP], CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Neurophysique et physiologie du système moteur ( NPSM ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Assistance publique - Hôpitaux de Paris (AP-HP)-AP-HP Hôpital Raymond Poincaré [Garches], Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP Hôpital Raymond Poincaré [Garches]
Subjects: Adult, Male, Visual perception, genetic structures, Apraxias, media_common.quotation_subject, medicine.medical_treatment, Motion Perception, Virtual reality, 050105 experimental psychology, Perceptual Disorders, 03 medical and health sciences, Fluency, User-Computer Interface, 0302 clinical medicine, Perception, medicine, Humans, 0501 psychology and cognitive sciences, media_common, Aged, Aged, 80 and over, Communication, Rehabilitation, business.industry, General Neuroscience, [SCCO.NEUR]Cognitive science/Neuroscience, 05 social sciences, Infarction, Middle Cerebral Artery, Middle Aged, Trunk, Paresis, Hemiparesis, [ SCCO.NEUR ] Cognitive science/Neuroscience, Arm, Virtual learning environment, Female, medicine.symptom, Psychology, business, 030217 neurology & neurosurgery, Psychomotor Performance, Cognitive psychology
Abstract: International audience; We investigated the visual perception of biological movement by people post-stroke, using minimal kinematic displays. A group of twenty patients and a group of twelve age-matched healthy controls were asked to judge movement fluency. The movements to judge were either displayed as an end-point dot or as a stick-figure of the arm and trunk. It was found that the perception of movement fluency was preserved post-stroke, however, with an increase in the variability of judgment. Moreover, the end-point dot representation ameliorated what was perceived and judged, presumably by directing attention to the important kinematic cues: smoothness and directness of the trajectory. We conclude that, despite perception of actions is influenced by the ability of the observer to execute the observed movement, hemiparesis has a mild effect on the perception of biological movement. Yet, a valuable virtual learning environment for upper-limb rehabilitation should be implemented to provide the observer with neither too much, nor too little information to maximize learning.
Published: 2011
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17. Sensitivity to change of two depression rating scales for stroke patients

Author: Charles Benaim, Pierre Decavel, Jacques Pélissier, Marc Bentabet, Jérôme Froger, Dominic Pérennou, Motricité - Plasticité, Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité de Rééducation Neurologique, Centre Hélio-Marin CHU Nîmes, Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), SPM, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications [Grenoble] ( TIMC-IMAG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Euromov (EuroMov), Université de Montpellier (UM), Santé, Plasticité, Motricité (TIMC-IMAG-SPM), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), and VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)
Subjects: Male, MESH: Psychiatric Status Rating Scales, MESH : Stroke, Stroke patient, medicine.medical_treatment, MESH: Depressive Disorder, MESH : Aged, MESH : Analysis of Variance, Severity of Illness Index, Mood scale, [ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, 0302 clinical medicine, MESH : Female, 030212 general & internal medicine, Depression (differential diagnoses), MESH: Aged, MESH : Aphasia, Rehabilitation, MESH: Middle Aged, Stroke Rehabilitation, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Middle Aged, MESH : Adult, Stroke, Female, MESH : Severity of Illness Index, Patient status, MESH : Sensitivity and Specificity, MESH : Psychiatric Status Rating Scales, Psychology, Clinical psychology, Adult, medicine.medical_specialty, MESH : Male, Physical Therapy, Sports Therapy and Rehabilitation, Sensitivity and Specificity, MESH: Stroke, 03 medical and health sciences, Rating scale, MESH: Severity of Illness Index, MESH: Analysis of Variance, Aphasia, medicine, Humans, MESH : Middle Aged, Sensitivity to change, Aged, MESH: Aphasia, Psychiatric Status Rating Scales, Analysis of Variance, Depressive Disorder, MESH: Humans, MESH : Humans, MESH: Adult, MESH: Sensitivity and Specificity, MESH: Male, MESH : Depressive Disorder, Physical therapy, MESH: Female, 030217 neurology & neurosurgery
Abstract: Objective: To assess the sensitivity to change of two depression scales for stroke patients: the Aphasic Depression Rating Scale (ADRS), which is a 9-item external assessment, and the Visual Analog Mood Scale (VAMS), which is a visual self-assessment scale. Patients: Forty-nine stroke patients admitted to two rehabilitation units. Methods: Symptoms of depression were assessed twice at a one-month interval (D0—D30) using the ADRS, the VAMS, and by a trained psychologist (PSY). Sensitivity to change was assessed by effect size and standardized response mean. A one-way ANOVA on ranks was performed to determine if the scales distinguished between deteriorated, stable and improved patient status. Spearman’s correlation coefficient (r) was used to assess the relationship between changes in PSY and changes in the ADRS and the VAMS between D0 and D30. Results: Mean depression scores at D0 and D30 were 2.6 ± 1.8 and 2.4 ± 1.7 (ADRS/10), 3.1 ± 2.9 and 3.0 ± 3.2 (VAMS/10), 2.9 ± 2.3 and 2.4 ± 2.4 (PSY/10). Percentages of deteriorated, stable and improved patient status were 22%, 45% and 33% (ADRS); 41%, 22% and 37% (VAMS); and 20%, 41% and 39% (PSY). Changes in PSY correlated with the ADRS (r = 0.72, P —6) and the VAMS (r = 0.41, P— 2). The ADRS was better than the VAMS in terms of effect size, standardized response mean and ability to discriminate between deteriorated, stable and improved patient status. This result was partly due to the difficulty encountered by nine (19%) patients in understanding directions to complete the VAMS. Conclusions: The ADRS is more sensitive than the VAMS for detecting changes in post-stroke depression. The VAMS is less appropriate in very cognitively impaired stroke patients.
Published: 2010
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18. Kinetics of neuromuscular changes during low-frequency electrical stimulation

Author: Maria Papaiordanidou, David Guiraud, Alain Varray, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Artificial movement and gait restoration (DEMAR), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Euromov (EuroMov), Université de Montpellier (UM), Université de Bourgogne (UB) - Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier (UM) - Centre National de la Recherche Scientifique (CNRS) - Université de Montpellier (UM) - Centre National de la Recherche Scientifique (CNRS) - Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria) - Institut National de Recherche en Informatique et en Automatique (Inria), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Artificial movement and gait restoration ( DEMAR ), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier ( LIRMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Varray, Alain, Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)
Subjects: Male, Physiology, MESH : Electric Stimulation, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], MESH: Muscle Contraction, Action Potentials, Stimulation, 0302 clinical medicine, Reference Values, Evoked potential, MESH : Muscle, Skeletal, MESH: Action Potentials, Motor Neurons, MESH: Muscle, Skeletal, Chemistry, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], MESH: Reference Values, MESH: Electric Stimulation, Anatomy, MESH: Follow-Up Studies, MESH : Adult, medicine.anatomical_structure, MESH: Muscle Fatigue, Muscle Fatigue, [ SCCO.NEUR ] Cognitive science/Neuroscience, MESH : Electromyography, medicine.symptom, Early phase, MESH: Motor Neurons, Muscle contraction, Muscle Contraction, Adult, medicine.medical_specialty, MESH : Motor Neurons, MESH : Male, MESH : Reference Values, MESH: Electromyography, 03 medical and health sciences, Cellular and Molecular Neuroscience, Median frequency, MESH : Action Potentials, Physiology (medical), Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Muscle, Skeletal, MESH: Humans, Electromyography, [SCCO.NEUR]Cognitive science/Neuroscience, MESH : Humans, [SCCO.NEUR] Cognitive science/Neuroscience, MESH : Follow-Up Studies, MESH: Adult, 030229 sport sciences, Motor neuron, Electric Stimulation, MESH : Muscle Fatigue, MESH: Male, Electrophysiology, Endocrinology, MESH : Muscle Contraction, Neurology (clinical), H-reflex, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: International audience; The purpose of the study was to examine the time course of neuromuscular fatigue components during a low-frequency electrostimulation (ES) session. Three bouts of 17 trains of stimulation at 30 HZ (4 s on, 6 s off) were used to electrically induce fatigue in the plantar flexor muscles. Before and after every 17-train bout, torque, electromyographic activity [expressed as root mean square (RMS) and median frequency (MF) values], evoked potentials (M-wave and H-reflex), and the level of voluntary activation (LOA, using twitch interpolation technique) were assessed. Torque during maximal voluntary contraction decreased significantly from the very first stimulation bout (-6.6 +/- 1.11%, P < 0.001) and throughout the session (-10.32 +/- 1.68% and -11.53 +/- 1.27%, for the second and third bouts, respectively). The LOA and RMS/Mmax values were significantly decreased during the ES session (-2.9 +/- 1.07% and -17.5 +/- 6.14%, P < 0.01 and P< 0.001, respectively, at the end of the protocol), while MF showed no changes. The Hmax/Mmax ratio and Mmax were not significantly modified during the session. All twitch parameters were significantly potentiated after the first bout and throughout the session (P < 0.001). The maximal torque decrease was evident from the early phase of a low-frequency ES protocol, with no concomitant inhibition of motoneuron excitability or depression of muscle contractile properties. These results are consistent with an early failure of the central drive to the muscle.
Published: 2010
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19. Contribution of each lower limb to upright standing in stroke patients

Author: Anne-Sophie Gissot, Nicolas Genthon, Jérôme Froger, Patrice Rougier, Dominic Pérennou, Jacques Pélissier, Laboratoire de modélisation des activités sportives (LMAS), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Unité de Rééducation Neurologique, Centre Hélio-Marin CHU Nîmes, Euromov (EuroMov), Université de Montpellier (UM), Motricité - Plasticité, Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de modélisation des activités sportives ( LMAS ), Laboratoire Interuniversitaire de Biologie de la Motricité ( LIBM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), and Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM )
Subjects: Male, Stroke patient, MESH: Proprioception, MESH : Aged, Neurological disorder, MESH : Pressure, MESH : Paresis, MESH: Postural Balance, 0302 clinical medicine, Reference Values, Task Performance and Analysis, Medicine, MESH : Task Performance and Analysis, MESH : Muscle, Skeletal, Postural Balance, media_common, MESH: Middle Aged, MESH: Reference Values, MESH: Recovery of Function, Biomechanical Phenomena, MESH : Proprioception, Visual Perception, 0305 other medical science, Cardiology and Cardiovascular Medicine, MESH: Pressure, MESH : Visual Perception, MESH : Recovery of Function, medicine.medical_specialty, media_common.quotation_subject, Movement, MESH : Weight-Bearing, Lower limb, MESH: Stroke, Feedback, Central nervous system disease, 03 medical and health sciences, Pressure, Humans, MESH : Middle Aged, MESH: Functional Laterality, MESH: Gait Disorders, Neurologic, MESH : Functional Laterality, Gait Disorders, Neurologic, Aged, Advanced and Specialized Nursing, Leg, MESH: Humans, MESH: Visual Perception, Posturography, MESH : Humans, MESH: Task Performance and Analysis, Recovery of Function, medicine.disease, Proprioception, Neurology (clinical), MESH : Leg, MESH: Female, 030217 neurology & neurosurgery, 030506 rehabilitation, MESH : Stroke, MESH : Movement, MESH : Gait Disorders, Neurologic, MESH: Movement, Functional Laterality, Weight-Bearing, [ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, MESH : Feedback, MESH: Weight-Bearing, MESH : Biomechanics, MESH : Female, MESH : Perceptual Disorders, Stroke, MESH: Biomechanics, MESH: Aged, MESH: Muscle, Skeletal, MESH: Feedback, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Middle Aged, Weight bearing asymmetry, MESH: Leg, Paresis, Female, MESH: Somatosensory Disorders, MESH : Male, MESH : Somatosensory Disorders, MESH : Reference Values, Neglect, Perceptual Disorders, MESH: Paresis, MESH : Postural Balance, Muscle, Skeletal, MESH: Perceptual Disorders, business.industry, MESH: Male, Physical therapy, Somatosensory Disorders, business
Abstract: Background and Purpose— To analyze the postural behavior of standing stroke patients: (1) To differentiate between postural impairment attributable to the neurological condition (deficits attributable to the cerebral lesion) and postural impairment attributable to new mechanical constraints caused by body weight asymmetry; (2) To assess the involvement of each limb in the postural impairment; (3) To better understand which clinical deficits underlie the postural impairment. Methods— The posturographic characteristics of each limb in 41 stroke patients (first hemispheric stroke: 16 left, 25 right cerebral lesions) required to stand in their preferred posture were compared to those in 40 matched healthy individuals required to stand asymmetrically. Results— Compared to normal individuals in a similar asymmetrical posture, stroke patients were more unstable. The weight bearing asymmetry and the lateral postural instability were mainly related to spatial neglect. The paretic limb was unable to bring into play a normal longitudinal pattern of the center of pressure, which reflects an impaired stabilization control. Overall postural instability occurred when the strong limb was unable to compensate for the postural impairment of the paretic limb. Conclusions— The weight bearing asymmetry of standing stroke patients is not the primary cause of their postural imbalance, which is rather the consequence of impaired control of postural stabilization involving both limbs. Weight bearing asymmetry may not be the principle target of rehabilitation programs aiming at restoring standing balance after stroke. Instead it is suggested that more account should be taken of the compensatory role of the strong limb.
Published: 2008
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20. Analysis of low back pain in adults with scoliosis

Author: Jean-Marie Casillas, Vincent Gremeaux, Christian Hérisson, Dominic Pérennou, Jacques Pélissier, Pascale Fabbro-Peray, Pôle Rééducation - Réadaptation (Médecine Physique et Réadaptation) (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Motricité - Plasticité, Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de biostatistiques, Institut Universitaire de Recherche Clinique, Euromov ( EuroMov ), Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Euromov (EuroMov), and Université de Montpellier (UM)
Subjects: Male, MESH: Chi-Square Distribution, MESH: Low Back Pain, MESH : Aged, MESH : Prospective Studies, MESH: Pain Measurement, Severity of Illness Index, MESH: Linear Models, MESH: Lumbar Vertebrae, [ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, 0302 clinical medicine, MESH: Aged, 80 and over, MESH : Scoliosis, MESH : Linear Models, Orthopedics and Sports Medicine, MESH : Pain Measurement, MESH : Female, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, MESH : Lumbar Vertebrae, Pain Measurement, Aged, 80 and over, MESH: Aged, Lumbar Vertebrae, MESH: Middle Aged, Cobb angle, MESH: Scoliosis, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Middle Aged, MESH : Adult, Low back pain, 3. Good health, medicine.anatomical_structure, Scoliosis, Female, MESH : Severity of Illness Index, medicine.symptom, Adult, medicine.medical_specialty, MESH : Male, Lumbar vertebrae, Central nervous system disease, 03 medical and health sciences, Lumbar, MESH: Severity of Illness Index, Severity of illness, medicine, Humans, MESH : Middle Aged, MESH : Aged, 80 and over, Aged, Chi-Square Distribution, MESH: Humans, MESH : Chi-Square Distribution, business.industry, MESH : Humans, MESH: Adult, medicine.disease, MESH: Male, MESH: Prospective Studies, MESH : Low Back Pain, Linear Models, Physical therapy, Neurology (clinical), business, Low Back Pain, MESH: Female, 030217 neurology & neurosurgery
Abstract: International audience; STUDY DESIGN: Prospective study of self-assessed symptom severity. OBJECTIVES: To carry out a comparative semiological analysis of pain in scoliotic and nonscoliotic adults with low back pain, and to study the factors that correlate with the severity of pain in scoliotic patients. SUMMARY OF BACKGROUND DATA: Low back pain is a frequent complaint in subjects with adult lumbar scoliosis. Few studies have taken an interest in the semiological specificities of lumbar pain in such patients. METHODS: Fifty adults with lumbar scoliosis and suffering from chronic low back pain and 50 nonscoliotic adults with chronic low back pain, matched for age and gender underwent a standard examination. The characteristics of the pain described in the 2 groups were compared. Relationships between the features of the scoliosis and the intensity of the pain were sought. RESULTS: There was no difference between the 2 groups with regard to pain severity (duration and intensity). The pain evolved more steadily in scoliotic patients. Inguinal pain (P < 0.001) and cruralgia (P < 0.05) were particularly associated with scoliosis. In scoliotics, the severity of the low back pain correlated well with the radiologic aspects: Cobb angle (P < 0.05), vertebral rotation (P < 0.05) and rotatory olisthesis (P < 0.05). Cruralgia was significantly associated with the presence of rotatory dislocation (P < 0.01). CONCLUSION: The pain felt by scoliotic adults has several semiological features, in particular the frequency of inguinal pain and cruralgia. Lumbar scoliosis with a great curvature and/or rotatory olisthesis increases the intensity of low back pain in adults. These findings suggest that the magnitude of the curvature and the existence of rotatory olisthesis must be targeted for prevention and treatment of the chronic low back pain in subjects with a lumbar scoliosis.
Published: 2008
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21. Study of Coordination Between Patients with Schizophrenia and Socially Assistive Robot During Physical Activity

Author: Ghiles Mostafaoui, Richard Schmidt, Delphine Capdevielle, Julie Boiché, Chloé Amiel, Hélène Serré, Lise Aubin, Ludovic Marin, Maelane Hellouin de Menibus, Stéphane Raffard, Equipes Traitement de l'Information et Systèmes (ETIS - UMR 8051), Ecole Nationale Supérieure de l'Electronique et de ses Applications (ENSEA)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), EuroMov - Digital Health in Motion (Euromov DHM), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Montpellier (UM), Euromov (EuroMov), Université de Montpellier (UM), GIPSA - Perception, Contrôle, Multimodalité et Dynamiques de la parole (GIPSA-PCMD), GIPSA Pôle Parole et Cognition (GIPSA-PPC), Grenoble Images Parole Signal Automatique (GIPSA-lab), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Grenoble Alpes (UGA), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM), College of the Holy Cross, and CY Cergy Paris Université (CY)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de l'Electronique et de ses Applications (ENSEA)
Subjects: 0209 industrial biotechnology, General Computer Science, Social Psychology, Schizophrenia (object-oriented programming), Context (language use), 02 engineering and technology, Interpersonal communication, Human–robot interaction, Synchronization, 020901 industrial engineering & automation, 0501 psychology and cognitive sciences, Electrical and Electronic Engineering, 050107 human factors, Physical activity, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, 05 social sciences, Robotics, Robotic, Human-Computer Interaction, Philosophy, Control and Systems Engineering, [SCCO.PSYC]Cognitive science/Psychology, Schizophrenia, Robot, Artificial intelligence, Psychology, business, Intrapersonal communication, Cognitive psychology
Abstract: This work was funding by local grant (Clinical research funding from CHU Montpellier), CNRS RHIAPS Project and DGA (Direction Générale des Armées).; International audience; The goal of this study was to analyze the interpersonal coordination of patients suffering from schizophrenia (SZ) using a humanoid robot NAO. NAO was controlled by a neurally-inspired model that enables motions synchronization between robot and human. Using a robot has the advantage in that it can be modified and controlled without being influenced by the human with whom they are interacting. More specifically, we were interested in non-intentional interpersonal coordination which has been found in previous studies to be preserved for SZ. We performed an experiment in which we asked patients and control participants to jointly perform fitness movements with the robot which was programmed to either synchronize with the human (a bidirectional condition) or move at a fixed frequency with them (a unidirectional condition). We showed that non-intentional interpersonal coordination was preserved for SZ during Human/Robot interaction (as for human/human interaction). Also, the best synchronization, stability and the best performance in term of speed were obtained with the bidirectional condition. Our results showed that, in this specific context of an interaction at preferential frequency of subject, there were only a few differences between SZ and controls in terms of interpersonal synchronization skills. Nevertheless, we observed more variability for SZ which could partly be explained by the weaker intrapersonal coordination that they exhibited.
Published: 2021
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22. Modification of matched distal ulnar resection for distal radio-ulnar joint arthropathy: Analysis of distal instability and radio-ulnar convergence

Author: Bertrand Coulet, Benjamin Degeorge, Michel Chammas, Cyril Lazerges, Pierre-Emmanuel Chammas, Hugo Barret, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Euromov (EuroMov), Université de Montpellier (UM), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Subjects: Joint Instability, Wrist Joint, musculoskeletal diseases, medicine.medical_specialty, Druj, Arthrodesis, medicine.medical_treatment, Radiography, Ulna, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, Matched ulnar head resection, 03 medical and health sciences, Grip strength, 0302 clinical medicine, Arthropathy, medicine, Extensor Carpi Ulnaris, Humans, Orthopedics and Sports Medicine, Rheumatoid arthritis, Range of Motion, Articular, Retrospective Studies, 030222 orthopedics, business.industry, Instability, 030229 sport sciences, musculoskeletal system, medicine.disease, Distal radioulnar joint, Surgery, body regions, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Convergence, business, Range of motion, Follow-Up Studies
Abstract: Background In palliative surgery on the distal radio-ulnar joint (DRUJ), ulnar head resection and the Sauve–Kapandji procedure are often followed by instability and radio-ulnar convergence. The objective of this study was to evaluate the stability of the DRUJ after modified matched distal ulnar resection performed alone or with partial or complete wrist arthrodesis. Hypothesis A modification of matched distal ulnar resection, consisting in reconstruction of the sixth compartment and dorsalisation of the extensor carpi ulnaris, minimises these complications, regardless of the cause and associated procedures. Patients and methods A single-centre retrospective study was conducted in 46 patients (50 wrists) who underwent modified matched distal ulnar resection. The 50 wrists fell into three groups: total wrist arthrodesis according to Millender, n = 21 (TWA group); radius to proximal row arthrodesis, n = 17 (RPRA group); and isolated matched distal ulnar resection, n = 12 (IMDUR group). Seventy per cent of patients had rheumatoid arthritis. Each patient underwent a clinical and radiographic assessment, with an analysis of radio-ulnar convergence, DRUJ stability, and ulno-carpal impingement, as well as of ulnar translation of the carpus in the IMDUR group. Results After the mean follow-up of 8.2 ± 5.4 years, 62% of patients were pain-free, with a mean VAS pain score of 1.3 ± 2.1, and 90% of patients said they would have the procedure again. Clinical and radiographic instability due to excessively proximal resection was noted in 2 (4%) wrists, of which 1 required repeat surgery. Ulno-carpal impingement due to excessively distal resection occurred in 2 (4%) wrists. No significant ulnar translation of the carpus was noted in the IMDUR group (DiBenedetto: 0.011 ± 1.9). Range of motion was similar in the three groups (mean pronation = 77 ± 17°; and mean supination = 79 ± 8°) (p > 0.05). Mean grip strength was 85 ± 35% compared to the other side. Discussion Our modification of matched distal ulnar resection minimises the complications specific of other ulnar head resection techniques or of the Sauve–Kapandji procedure, namely, radio-ulnar convergence and DRUJ instability. Level of proof IV; retrospective comparative study.
Published: 2020
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23. Criteria for inclusion in programs of functional restoration for chronic low back pain: Pragmatic Study

Author: Marina Assadourian, Laure Gossec, Bruno Fautrel, Johann Beaudreuil, B. Duplan, Sophia Ascione, Pierre Letellier, Laetitia Morardet, Arnaud Dupeyron, Florian Bailly, Nada Ibrahim-Nasser, Isabelle Griffoul, Antoine Potel, Myrianne Le Ralle, Violaine Foltz, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Métropole Savoie [Chambéry], Service de Rhumatologie [CHU Lariboisière], Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Euromov (EuroMov), Université de Montpellier (UM), Centre Hospitalier Régional d'Orléans (CHRO), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de Rhumatologie [CHU Pitié Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Herrada, Anthony
Subjects: Male, 030506 rehabilitation, Chronic pain, Anxiety, Hospital Anxiety and Depression Scale, 0302 clinical medicine, Medicine, Orthopedics and Sports Medicine, Practice Patterns, Physicians', 10. No inequality, Referral and Consultation, Pain Measurement, Public health, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Depression, Rehabilitation, Middle Aged, Combined Modality Therapy, 3. Good health, Oswestry Disability Index, Sick leave, Chronic low back pain, Female, France, Sick Leave, medicine.symptom, 0305 other medical science, Adult, medicine.medical_specialty, Referral, 03 medical and health sciences, Humans, Exercise, Physical activity, business.industry, Patient Selection, Odds ratio, medicine.disease, Cross-Sectional Studies, Logistic Models, Multivariate Analysis, Physical therapy, Observational study, Self Report, business, Low Back Pain, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract: International audience; Background: Individuals with chronic low back pain (cLBP) may benefit from multimodal functional restoration programs (FRPs).Objective: The aim of this study was to analyze characteristics of individuals with cLBP who were referred or not to an FRP. Because cLBP is a bio-psycho-social disorder, medical and social parameters were analysed.Methods: This was an observational cross-sectional study performed in 2017 in 6 tertiary centres in France. Consecutive individuals with cLBP visiting a rheumatologist or physical medicine and rehabilitation physician were included. Individuals referred or not to an FRP were compared by demographic characteristics, duration of sick leave over the past year, self-reported physical activity>1h/week, pain (numeric rating scale 0-10), anxiety/depression (Hospital Anxiety and Depression Scale), disability (Oswestry Disability Index) and kinesiophobia (Tampa Kinesiophobia Scale). Univariate and multivariate logistic regression analyses were performed, estimating odds ratios (ORs) and 95% confidence intervals (CIs).Results: We included 147 individuals with cLBP. The mean (SD) age was 49 (12) years and 88 (60%) were women; 58 (38%) were referred to an FRP. On multivariate analysis, referral to an FRP was associated with reduced pain level (OR: 0.95, 95% CI: 0.91-0.99, for each 1-point increase in pain score), self-reported lack of physical activity (OR: 0.84, 95% CI: 0.72-0.98) and longer sick leave (OR: 1.03, 95% CI: 1.01-1.05, for 30 more days of sick leave).Conclusion: In this multicentric observational study, referral to an FRP was linked to pain, self-reported physical activity and sick leave but not medical characteristics assessed. These findings confirm the bio-psycho-social approach of FRPs for cLBP.
Published: 2020
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24. Rhythm disturbances as a potential early marker of Parkinson’s disease in idiopathic REM sleep behavior disorder

Author: Christian Geny, Valérie Driss, Simone Dalla Bella, Pascale Homeyer, Chloé Gonzalvez, Bertrand Carlander, Benoît G. Bardy, Valérie Cochen De Cock, Florence Galtier, Loic Damm, Nicolas Pageot, Aurélie Giordano, C. Lebrun, Beatriz Abril, Marie Christine Picot, Delphine de Verbizier, Giovanni Castelnovo, CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi-Institut National de la Santé et de la Recherche Médicale (INSERM), Euromov (EuroMov), Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), and Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)
Subjects: 0301 basic medicine, Male, medicine.medical_specialty, Parkinson's disease, media_common.quotation_subject, Neurosciences. Biological psychiatry. Neuropsychiatry, REM Sleep Behavior Disorder, Audiology, Motor Activity, REM sleep behavior disorder, 03 medical and health sciences, Olfaction Disorders, 0302 clinical medicine, Rhythm, Dopamine, Perception, medicine, Humans, RC346-429, Research Articles, media_common, Aged, Tomography, Emission-Computed, Single-Photon, Dopamine Plasma Membrane Transport Proteins, business.industry, General Neuroscience, Dysautonomia, Parkinson Disease, Middle Aged, medicine.disease, Tapping rate, 030104 developmental biology, Finger tapping, Time Perception, Auditory Perception, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), Neurology. Diseases of the nervous system, medicine.symptom, Cues, business, 030217 neurology & neurosurgery, Biomarkers, Psychomotor Performance, medicine.drug, Research Article, RC321-571
Abstract: International audience; Objective: We aimed to identify timing distortions in production and perception of rhythmic events in patients with idiopathic REM sleep behavior disorder (iRBD) as early markers of Parkinson's disease (PD).Methods: Rhythmic skills, clinical characteristics, dysautonomia, depression, and olfaction were compared in 97 participants, including 21 participants with iRBD, 38 patients with PD, and 38 controls, matched for age, gender, and education level. Rhythmic disturbances can be easily detected with dedicated motor tasks via a tablet application. Rhythm production was tested in two conditions: to examine the ability to generate a spontaneous endogenous rhythm, tapping rate and variability in a finger tapping task without external stimulation was measured, while the ability to synchronize to an external rhythm was tested with finger tapping to external auditory cues. Rhythm perception was measured with a task, in which the participants had to detect a deviation from a regular rhythm. Participants with iRBD had dopamine transporter imaging.Results: Participants with iRBD and PD revealed impaired spontaneous rhythm production and poor rhythm perception compared to controls. Impaired rhythm production was correlated with olfaction deficits, dysautonomia, impaired non-motor aspects of daily living, and dopamine uptake measures.Conclusions: Participants with iRBD show impaired rhythm production and perception; this impairment is correlated with other early markers for PD. Testing rhythmic skills with short and inexpensive tests may be promising for screening for potential future PD in iRBD patients.
Published: 2020
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25. Neurolytic blockade of the obturator nerve for intractable spasticity of adductor thigh muscles

Author: Eric Viel, Jacques Ripart, Jean Jacques Eledjam, D. Perennou, Jacques Pélissier, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Euromov ( EuroMov ), Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Euromov (EuroMov), and Université de Montpellier (UM)
Subjects: Male, MESH: Neuralgia, MESH : Aged, MESH : Thigh, Thigh, MESH : Ethanol, MESH : Muscle Spasticity, [ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, 0302 clinical medicine, 030202 anesthesiology, MESH : Female, MESH : Muscle, Skeletal, Gait, Neurolysis, MESH: Treatment Outcome, MESH: Aged, MESH: Muscle, Skeletal, MESH: Middle Aged, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Nerve Block, Health Care Costs, MESH: Nerve Block, Middle Aged, MESH : Adult, 3. Good health, medicine.anatomical_structure, Treatment Outcome, Muscle Spasticity, MESH : Obturator Nerve, Anesthesia, Obturator nerve, Female, MESH: Pain, medicine.symptom, Paraplegia, Obturator Nerve, MESH : Health Care Costs, MESH : Pain, Adult, MESH : Gait, medicine.medical_specialty, MESH: Ethanol, MESH : Feasibility Studies, MESH : Male, Pain, MESH: Health Care Costs, MESH : Treatment Outcome, Injections, 03 medical and health sciences, MESH : Nerve Block, medicine, Humans, MESH: Injections, MESH : Middle Aged, Spasticity, Muscle, Skeletal, MESH: Obturator Nerve, Aged, MESH: Muscle Spasticity, MESH: Humans, Ethanol, business.industry, MESH: Gait, MESH : Humans, Obturator canal, MESH: Adult, medicine.disease, MESH : Injections, MESH: Male, Surgery, Anesthesiology and Pain Medicine, Feasibility Studies, Neuralgia, MESH : Neuralgia, Adductor muscles, business, MESH: Feasibility Studies, MESH: Female, 030217 neurology & neurosurgery, muscle spasm, MESH: Thigh
Abstract: International audience; Neurolytic blockade is one of the therapeutic possibilities to treat spasticity of various muscles. In patients with spasticity of the adductor thigh muscles, a percutaneous approach to the obturator nerve is often difficult. We describe a new approach to the obturator nerve and we examine its feasibility. The second objective was to assess the efficacy of obturator neurolysis for the management of adductor thigh muscle pain and spasticity associated with hemiplegia or paraplegia. Nerve blocks were performed via a combined approach using fluoroscopy and nerve stimulation to identify the obturator nerve. Neurolysis was performed by injection of 65% ethanol. We performed 27 blocks in 23 patients. Technical evaluation was achieved in terms of number of attempted needle insertions, time to accurate location of the nerve and success rate. The efficacy of the block was assessed using four scores: degree of alleviation of muscle spasm and triple flexion of the lower limb, improvement of gait and facilitation of hygienic care. Success rate of the technique was 100% with a time to accurate nerve location of 130+/-35 s. Compared with scores measured immediately before the block, all studied parameters were significantly improved. Efficiency was significant on adductor muscle spasticity (p
Published: 2002
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26. Training Load Responses Modelling in Elite Sports: How to Deal with Generalisation?

Author: Stéphane Perrey, Frank Imbach, Romain Chailan, Thibaut Méline, Robin Candau, Euromov (EuroMov), Université de Montpellier (UM), Seenovate, Lab Europeen Performance Sante Altitude, Université de Perpignan Via Domitia (UPVD), Dynamique Musculaire et Métabolisme (DMEM), and Université de Montpellier (UM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: 03 medical and health sciences, 0302 clinical medicine, Operations research, Computer science, [SDV]Life Sciences [q-bio], Elite, 030229 sport sciences, Training load, 030217 neurology & neurosurgery
Abstract: This study aims to provide a transferable methodology in the context of sport performance modelling, with a special focus to the generalisation of models. Data were collected from seven elite Short track speed skaters over a three months training period. In order to account for training load accumulation over sessions, cumulative responses to training were modelled by impulse, serial and bi-exponential responses functions. The variable dose-response (DR) model was compared to elastic net (ENET), principal component regression (PCR) and random forest (RF) models, while using cross-validation within a time-series framework. ENET, PCR and RF models were fitted either individually (MI) or on the whole group of athletes (MG). Root mean square error criterion was used to assess performances of models. ENET and PCR models provided a significant greater generalisation ability than the DR model (p = 0.012, p < 0.001, p = 0.005 and p < 0.001 for ENETI, ENETG, PCRI and PCRG, respectively). Only ENETI, ENETG and RFI were significantly more accurate in prediction than DR (p = 0.020, p < 0.001 and p = 0.043, respectively). In conclusion, ENET achieved greater generalisation and predictive accuracy performances. Thus, building and evaluating models within a generalisation enhancing procedure is a prerequisite for any predictive modelling.
Published: 2021

27. Malnutrition according to ESPEN definition predicts long-term mortality in general older population: Findings from the EPIDOS study-Toulouse cohort

Author: Hubert Blain, Cédric Annweiler, Ester Marco, Yves Rolland, Olga Vázquez-Ibar, Xavier Duran, Josep M. Muniesa, Dolores Sánchez-Rodríguez, Ferran Escalada, Anne-Marie Schott, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Pôle Information Médicale Evaluation Recherche (IMER), Parcours santé systémique (P2S), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Ostéoporose et Qualité Osseuse, Université de Lyon-Université de Lyon-IFR62-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Euromov (EuroMov), Université de Montpellier (UM), Service de médecine interne et gérontologie clinique [Angers], Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL), and Université de Nantes (UN)-Université de Nantes (UN)
Subjects: 0301 basic medicine, Consensus, ESPEN, Nutritional Sciences, Population, 030209 endocrinology & metabolism, Kaplan-Meier Estimate, Clinical nutrition, Community-dwelling, Critical Care and Intensive Care Medicine, 03 medical and health sciences, 0302 clinical medicine, Weight loss, Prevalence, medicine, Humans, Prospective Studies, Mortality, education, Survival analysis, Aged, 80 and over, 2. Zero hunger, education.field_of_study, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Malnutrition, Confounding, EPIDOS, medicine.disease, 3. Good health, Cohort, Body Composition, Female, Independent Living, Older people, medicine.symptom, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Cohort study, Demography
Abstract: S U M M A R Y Background The European Society of Clinical Nutrition and Metabolism (ESPEN) has developed a consensus definition of malnutrition. This study aimed to determine the prevalence of malnutrition according to the ESPEN definition in otherwise healthy community-dwelling older women and to explore its value for predicting long-term mortality in this population. Methods This prospective population-based cohort study included 181 women (age ≥75 years) from a subsample of the EPIDemiologie de l'OSteoporose (EPIDOS) study participants from Toulouse. Inclusion criteria were the availability of the data on variables required to apply the ESPEN definition and survival after 7 years of follow-up. Primary outcome was mortality at 12-year follow-up; main covariates were malnutrition assessment according to the ESPEN consensus and its components (unintentional weight loss, BMI, and FFMI). Body composition was assessed by dual-energy X-ray absorptiometry at baseline and at 7-year follow-up. Kaplan-Meier survival curves and adjusted Cox regressions were performed. Analysis was adjusted for age, hypertension, diabetes mellitus, and coronary heart disease as potential confounders. Results Complete data were available for 179 of the 181 women in the EPIDOS-Toulouse cohort (83.1 ± 2.2 years) and 13 (7.3%) fulfilled the ESPEN definition for malnutrition at 7-year follow-up. Malnutrition was associated with increased risk of mortality (adjusted HR = 4.4 [95%CI: 1.7–11.3]). Among the ESPEN components, only BMI was associated with increased mortality (adjusted HR=0.6 [95%CI: 0.4–0.9]). Conclusions Although malnutrition prevalence according to the ESPEN definition was relatively low (7.3%) in this sample of otherwise healthy community-dwelling older French women, malnutrition was associated with 4.4-fold higher mortality risk at 12-year follow-up.
Published: 2019
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28. Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

Author: Christian Geny, Marie-Christine Gély-Nargeot, Sophie Bayard, Alexia Rossignol, Cindy Lebrun, Euromov (EuroMov), Université de Montpellier (UM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Dynamique des capacités humaines et des conduites de santé (EPSYLON), and Université de Montpellier (UM)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université Montpellier 1 (UM1)
Subjects: Adult, Male, 050103 clinical psychology, Parkinson's disease, insomnia, medicine.medical_treatment, Comorbidity, Anxiety, Single-subject design, Cognitive behavioral therapy for insomnia, Single-Case Studies as Topic, [SCCO]Cognitive science, 03 medical and health sciences, 0302 clinical medicine, Arts and Humanities (miscellaneous), Quality of life, Sleep Initiation and Maintenance Disorders, mental disorders, Insomnia, medicine, Humans, 0501 psychology and cognitive sciences, Aged, non‐motor symptoms, Depression, Parkinsonʼs disease, 05 social sciences, Parkinson Disease, Middle Aged, medicine.disease, cognitive behavioral therapy, 030227 psychiatry, 3. Good health, Cognitive behavioral therapy, Clinical Psychology, Treatment Outcome, [SCCO.PSYC]Cognitive science/Psychology, Quality of Life, Female, Sleep diary, Self Report, medicine.symptom, single‐case design with multiple baselines, Psychology, Clinical psychology
Abstract: Objective: To test the efficacy of cognitive behavioral therapy for insomnia (CBT‐i) in Parkinsonʼs Disease (PD) and to evaluate its impact on indices of daytime and psychological functioning. Method: Fifteen patients with insomnia disorder (ID) comorbid to PD were enrolled in a single‐case design with multiple baselines. Total wake time, sleep efficiency, and daytime sleepiness were recorded on a sleep diary. Selfreported measures of insomnia, anxiety and depressive symptoms, health‐related quality of life, and psychological variables perpetuating ID were completed. All patients also underwent a clinical interview for ID diagnosis. Results: CBT‐i was associated with significant changes in sleep variables and ID criteria. Significant positive treatment‐ related effects were also noted for all indices of daytime and psychological functioning, and for variables perpetuating ID. All of these improvements were well maintained at 3‐month follow‐up. Conclusion: CBT‐i is a promising therapeutic avenue for patients with PD.
Published: 2019
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29. Fractal properties in sensorimotor variability unveil internal adaptations of the organism before symptomatic functional decline

Author: Éric Viel, Arnaud Dupeyron, Stéphane Perrey, Kjerstin Torre, Grégoire Vergotte, Euromov (EuroMov), Université de Montpellier (UM), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), and Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)
Subjects: Adult, Male, Causalgia, Time series, Acclimatization, media_common.quotation_subject, Science, Early detection, Article, 050105 experimental psychology, Adaptability, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Fractal, Motor control, Humans, 0501 psychology and cognitive sciences, Functional ability, Functional decline, Organism, media_common, Multidisciplinary, 05 social sciences, Perspective (graphical), Healthy subjects, Middle Aged, Adaptation, Physiological, Fractals, Acoustic Stimulation, Medicine, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Sensorimotor Cortex, Psychology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery, Cognitive psychology
Abstract: If health can be defined as adaptability, then measures of adaptability are crucial. Convergent findings across clinical areas established the notion that fractal properties in bio-behavioural variability characterize the healthy condition of the organism, and its adaptive capacities in general. However, ambiguities remain as to the significance of fractal properties: the literature mainly discriminated between healthy vs. pathological states, thereby loosing perspective on the progression in between, and overlooking the distinction between adaptability and effective adaptations of the organism. Here, we design an experimental tapping paradigm involving gradual feedback deprivation in groups of healthy subjects and one deafferented man as a pathological-limit case. We show that distinct types of fractal properties in sensorimotor behaviour characterize, on the one hand impaired functional ability, and on the other hand internal adaptations for maintaining performance despite the imposed constraints. Findings may prove promising for early detection of internal adaptations preceding symptomatic functional decline.
Published: 2019
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30. Frequency‐dependent and montage‐based differences in phosphene perception thresholds via transcranial alternating current stimulation

Author: Ian D Evans, Sarah P. Loughran, Rodney J. Croft, Alexandre Legros, Stephen Palmisano, University of Western Ontario (UWO), Lawson Health Research Institute [London (ON) Canada], Euromov (EuroMov), and Université de Montpellier (UM)
Subjects: Adult, Male, medicine.medical_specialty, Visual perception, genetic structures, Physiology, media_common.quotation_subject, Phosphenes, Biophysics, Stimulation, 02 engineering and technology, Audiology, Transcranial Direct Current Stimulation, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Perception, 0202 electrical engineering, electronic engineering, information engineering, medicine, Humans, Radiology, Nuclear Medicine and imaging, Set (psychology), Electrodes, Bioelectromagnetics, ComputingMilieux_MISCELLANEOUS, media_common, Transcranial alternating current stimulation, [SCCO.NEUR]Cognitive science/Neuroscience, 020206 networking & telecommunications, General Medicine, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, medicine.anatomical_structure, Phosphene, Sensory Thresholds, Scalp, Female, Psychology, Photic Stimulation
Abstract: It is well known that applying transcranial alternating current stimulation (tACS) to the scalp can generate artefactual visual perceptions of flashing or shimmering light known as phosphenes. The thresholds for generating these phosphenes have been used by international standards bodies to provide conservative estimates of the field strength required to interfere with human neural functioning and set safety limits accordingly. However, the precise relationship between electric currents and phosphene perception thresholds remains uncertain. The present study used tACS to systematically investigate the effects of the location and the frequency of stimulation on phosphene perception thresholds. These thresholds were obtained from 24 participants using a within-subject design as a function of scalp stimulation sites (FPz-Cz versus Oz-Cz) and stimulation frequency (2-30 Hz in steps of 2 Hz). Phosphene perception thresholds were consistently lower for FPz-Cz stimulation, and regardless of tACS location were lowest for 16 Hz stimulation. Threshold variation between participants was very small, which is meaningful when setting standards based on phosphenes. Bioelectromagnetics. 2019;40:365-374. © 2019 Bioelectromagnetics Society.
Published: 2019
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31. Concurrent anodal transcranial direct-current stimulation and motor task to influence sensorimotor cortex activation

Author: Pierre Besson, John C. Rothwell, Stéphane Perrey, Gérard Dray, Makii Muthalib, Euromov (EuroMov), Université de Montpellier (UM), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and University College of London [London] (UCL)
Subjects: Adult, Male, 0301 basic medicine, Online and offline, Plasticity, medicine.medical_treatment, Motor Activity, Transcranial Direct Current Stimulation, 03 medical and health sciences, 0302 clinical medicine, Functional neuroimaging, Neuromodulation, Neuroplasticity, Humans, Medicine, Online, Molecular Biology, Sensorimotor cortex, ComputingMilieux_MISCELLANEOUS, Neuronal Plasticity, Spectroscopy, Near-Infrared, Transcranial direct-current stimulation, business.industry, General Neuroscience, Motor task, High-definition montage, 030104 developmental biology, medicine.anatomical_structure, Time course, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Sensorimotor Cortex, Neurology (clinical), business, Neurovascular coupling, Neuroscience, Psychomotor Performance, 030217 neurology & neurosurgery, Developmental Biology
Abstract: Functional targeting with anodal high-definition transcranial direct current stimulation (HD-atDCS) of involved brain areas during performance of a motor task (online) may facilitate sensorimotor cortex neuroplasticity compared to performing the motor task after HD-atDCS (offline). The aim of this study was to employ functional near-infrared spectroscopy to compare the time course of motor task-related changes in sensorimotor cortex activation between online and offline HD-atDCS. We hypothesized that online HD-atDCS would have a greater effect on task-related sensorimotor cortex activation than offline HD-atDCS. In a within-subject sham controlled and randomized study design, 9 healthy participants underwent 3 HD-atDCS sessions (online, offline and sham) targeting the left sensorimotor cortex separated by 1 week. Functional near-infrared spectroscopy hemodynamic changes were measured from the left sensorimotor cortex during a simple finger opposition motor task before (Pre), immediately (T1) and 30 min after (T2) each session. The movement rates were not different between (online, offline, sham) or within (Pre, T1, T2) sessions. At T2, online HD-atDCS was associated with a significant increase (large effect size) in sensorimotor cortex activation (Hedges g = 1.01, p 0.001) when compared to sham; there was a nonsignificant trend to increase activation between offline and sham (Hedges g = 0.52, p = 0.05) and between online and offline (Hedges g = 0.53, p = 0.06). Concurrent application of HD-atDCS during a motor task may produce larger sensorimotor cortex activation than sequential application.
Published: 2019
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32. Risk factors of pelvic pressure ulcer recurrence after primary skin flap surgery in people with spinal cord injury

Author: C. Mauri, Nicolas Frasson, A. Gelis, C. Herlin, Arnaud Dupeyron, B. Amara, C. Verollet, H. Rouays, Jacques Morel, J.-P. Daures, C. Jourdan, Isabelle Almeras, Service de Médecine Physique et Réadaptation [CHU de Grenoble] (MPR), Centre Hospitalier Universitaire [Grenoble] (CHU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Hôpital Lapeyronie [Montpellier] (CHU), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Euromov (EuroMov), Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), and Institut Universitaire de Recherche Clinique
Subjects: Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, Spinal cord injury, Surgical Flaps, Pelvis, Young Adult, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Recurrence, Risk Factors, medicine, Humans, Orthopedics and Sports Medicine, Risk factor, Spinal Cord Injuries, Aged, Proportional Hazards Models, Retrospective Studies, Aged, 80 and over, Pressure Ulcer, business.industry, Flap surgery, Rehabilitation, Hazard ratio, Colostomy, Retrospective cohort study, Skin Transplantation, Middle Aged, medicine.disease, Confidence interval, 3. Good health, Surgery, Treatment Outcome, Regression Analysis, Female, Observational study, 0305 other medical science, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract: Background Flap surgery for deep pelvic pressure ulcers (PPUs) has been found effective, but the recurrence rate remains high and few risk factors have been identified. Objective We evaluated risk factors for PU recurrence after primary flap surgery in people with spinal cord injury (SCI). Patients and methods This observational retrospective study based on medical charts included all individuals with SCI who underwent primary flap surgery for a PPU in the Herault department in France between 2006 and 2014. Overall, 100 biomedical, psychological, socioeconomic and care management factors were studied. The primary outcome was PPU recurrence (surgical site and/or other pelvic site). The secondary outcome was recurrence at the surgical site. Cox proportional hazards regression was used to determine associated factors, estimating hazard ratios (HRs) and 95% confidence intervals (CIs). Results We included 85 patients. Half had a PPU recurrence, and in one-third, the recurrence was at the surgical site. On multivariate analysis, global PPU recurrence was associated with colostomy (HR = 2.79) and living with a partner (HR = 2.29). Non-traumatic SCI and sacral wound were associated with PPU recurrence (HR = 3.39, HR = 0.48) and recurrence at the surgical site (HR = 3.3, HR = 0.3). Conclusion Risk factors of PPU recurrence are based on both biomedical and social models. After primary flap surgery, the risk of recurrence justifies regular follow-up and strict monitoring.
Published: 2019
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33. Validation of a Simple Metabolic-Equivalent-of-Task Sensor Based on a Low-Cost NFC RFID Wristband

Author: K. Bakhti, Arnaud Vena, Simon Pla, Denis Mottet, Benjamin Saggin, S. Fazilleau, Yassin Belaizi, Brice Sorli, Institut d’Electronique et des Systèmes (IES), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Matériaux, MicroCapteurs et Acoustique (M2A), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Euromov (EuroMov), Université de Montpellier (UM), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Subjects: Computer science, NFC, Metabolic equivalent of task, Calorimetry, 01 natural sciences, Signal, 03 medical and health sciences, 0302 clinical medicine, Transfer (computing), Radio-frequency identification, Session (computer science), Electrical and Electronic Engineering, Instrumentation, ComputingMilieux_MISCELLANEOUS, Sensor, RFID, SIMPLE (military communications protocol), Physical activity, business.industry, Uniaxial magnetic anisotropy, 010401 analytical chemistry, Wrist, Magnetometer, [SPI.TRON]Engineering Sciences [physics]/Electronics, 0104 chemical sciences, Algorithm, Radiofrequency identification, MET, Energy expenditure, business, 030217 neurology & neurosurgery, Computer hardware, Near-field communication, Data transmission
Abstract: In this paper, a simple solution allowing continuous actimetry with an uniaxial magnetometer is presented. Worn on the wrist to monitor the forearm tilt, it can estimate the instantaneous metabolic-equivalent-of-task during physical activity. Autonomous acquisition and data transfer are managed by a radio frequency identification chip supporting the near field communication (NFC) standard. Thus, the solution can transfer measurements to an NFC-enabled device (computer and smartphone) that runs a custom algorithm. The algorithm output signal was indirectly calibrated to an accurate calorimetry device to display the real energy expenditure of the user during the physical activity session.
Published: 2019
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34. Fluoxetine for the Symptomatic Treatment of Multiple System Atrophy: The MSA-FLUO Trial

Author: Marc Vérin, Anne Pavy-Le Traon, Vanessa Rousseau, Margherita Fabbri, Alexandra Foubert-Samier, Wassilios G. Meissner, François Tison, Philippe Couratier, Agnès Sommet, Luc Defebvre, Valérie Cochen De Cock, Santiago Perez-Lloret, Franck Durif, Christine Tranchant, Claire Thalamas, Jean-Philippe Azulay, Philippe Remy, Jean-Christophe Corvol, Philippe Damier, Olivier Rascol, Jean-Luc Houeto, Christian Geny, Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), EuroMov - Digital Health in Motion (Euromov DHM), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Montpellier (UM), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), CHU Bordeaux [Bordeaux], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Hôpital de la Timone [CHU - APHM] (TIMONE), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Limoges, Centre hospitalier universitaire de Nantes (CHU Nantes), Lille Neurosciences & Cognition - U 1172 (LilNCog (ex-JPARC)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Clermont-Ferrand, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Euromov (EuroMov), Université de Montpellier (UM), CHI Créteil, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes (INCR), CHU Pontchaillou [Rennes], Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), NS-Park/FCRIN Network, UMS 015, Centre d’Excellence en Maladies Neurodégénératives (NeuroToul), CHU Toulouse [Toulouse], Clinique Beau Soleil [Montpellier], Pontifical Catholic University of Argentina (UCA), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Nord Laennec [CHU Nantes], Lille Neurosciences & Cognition - U 1172 (LilNCog), CHU Lille, CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Henri Mondor, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Les Hôpitaux Universitaires de Strasbourg (HUS), University of Otago [Dunedin, Nouvelle-Zélande], Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Henri Mondor [Créteil], and Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR)
Subjects: 0301 basic medicine, medicine.medical_specialty, Serotonin reuptake inhibitor, [SDV]Life Sciences [q-bio], multiple system atrophy, ENSAYO CLINICO, Placebo, law.invention, 03 medical and health sciences, NEUROBIOLOGIA, 0302 clinical medicine, Atrophy, Randomized controlled trial, Double-Blind Method, Rating scale, law, Internal medicine, Surveys and Questionnaires, medicine, ATROFIA MULTISISTÉMICA, Humans, symptomatic treatment, Fluoxetine, business.industry, Beck Depression Inventory, fluoxetine, ENFERMEDADES NEURODEGENERATIVAS, Parkinson Disease, clinical trial, medicine.disease, Confidence interval, 3. Good health, ENFERMEDAD DE PARKINSON, 030104 developmental biology, Treatment Outcome, Neurology, Quality of Life, placebo, TRATAMIENTO MEDICO, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug
Abstract: Fil: Rascol, Olivier. Universidad de Toulouse. Hospital Universitario de Toulouse; Francia Fil: Rascol, Olivier. Centro NeuroToul COEN; Francia Fil: Rascol, Olivier. Clínica de Toulouse. Centro de Investigación. Departamentos de Neurociencias y Farmacología Clínica; Francia Fil: Cochen De Cock, Valérie. Clínica Beau Soleil. Departamento de Neurología; Francia Fil: Cochen De Cock, Valérie. Universidad de Montpellier. EuroMov Digital Health in Motion; Francia Fil: Pavy-Le Traon, Anne. Centro de referencia de atrofia multisistémica; Francia Fil: Pavy-Le Traon, Anne. Universidad de Toulouse. Hospital Universitario de Toulouse. Instituto de Enfermedades Cardiovasculares y Metabólicas. Centro de Investigación Clínica de Toulouse. Departamento de Neurociencias; Francia Fil: Foubert-Samier, Alexandra. Universidad de Toulouse. Hospital Universitario de Toulouse. Instituto de Enfermedades Cardiovasculares y Metabólicas. Departamento de Neurociencias, Centro de investigación Clínica de Toulouse; Francia Fil: Thalamas, Claire. Universidad de Toulouse. Hospital Universitario de Toulouse. Centro de Investigación Clínica de Toulouse; Francia Fil: Thalamas, Claire. Hospital Universitario de Burdeos; Francia Fil: Sommet, Agnès. Red Francesa de Infraestructura de Investigación Clínica; Francia Fil: Pérez Lloret, Santiago. Universidad Abierta Interamericana. Centro de Investigaciones Biomédicas; Argentina Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina Fil: Fabbri, Margherita. Red Francesa de Infraestructura de Investigación Clínica; Francia Fil: Azulay, Jean Philippe. Universidad de Aix-Marsella. Sistema de Hospitales Universitarios Públicos de Marsella; Francia Fil: Corvol, Jean-Christophe. Universidad de la Sorbona; Francia Fil: Corvol, Jean-Christophe. Hospital de la Pitié-Salpêtrière; Francia Fil: Corvol, Jean-Christophe. Red Francesa de Infraestructura de Investigación Clínica; Francia Fil: Couratier, Philippe. Red Francesa de Infraestructura de Investigación Clínica; Francia Fil: Damier, Philippe. Hospital Nord Laennec. Centro de Investigación Clínica; Francia Fil: Defebvre, Luc. Universidad en Lille; Francia Fil: Defebvre, Luc. Hospital Universitario de Marsella. Departamento de Neurología y Patología del Movimiento; Francia Fil: Durif, Franck. Centro Hospitalario Universitario, Clermont-Ferrand. Departamento de Neurología; Francia Fil: Durif, Franck. Red Francesa de Infraestructura de Investigación Clínica; Francia Fil: Geny, Christian. Universidad de Montpellier. Departamento de Neurología; Francia Fil: Houeto, Jean-Luc. Centro Hospitalario Universitario de Limoges; Francia Fil: Houeto, Jean-Luc. Centro de referencia de atrofia multisistémica. Departamento de Neurología. Centro de Expertos en Parkinson; Francia Fil: Rascol, Olivier. Centro de referencia de atrofia multisistémica; Francia Fil: Remy, Philippe. Red Francesa de Infraestructura de Investigación Clínica. Centros Expertos en Parkinson; Francia Fil: Remy, Philippe. Instituto de Investigaciones Biomédicas Mondor; Francia Fil: Tranchant, Christine. Hospital Universitario de Estrasburgo. Red Francesa de Infraestructura de Investigación Clínica. Departamento de Neurología; Francia Fil: Verin, Marc. Universidad de Rennes. Hospital Universitario de Rennes. Red Francesa de Infraestructura de Investigación Clínica. Centro de expertos en Parkinson; Francia Fil: Tison, François. Centro de referencia de atrofia multisistémica. Departamento de Neurología de Enfermedades Neurodegenerativas; Francia Fil: Meissner, Wassilios G. Instituto de Investigación del Cerebro; Nueva Zelanda Fil: Meissner, Wassilios G. Universidad de Otago. Departamento de Medicina; Nueva Zelanda Abstract: Background: There are no effective treatments for multiple system atrophy (MSA). Objective: The objective of this study was to assess the efficacy and safety of the serotonin reuptake inhibitor fluoxetine (40 mg/d) for the symptomatic treatment of MSA. Methods: This was a double-blind, parallel-group, placebo-controlled, randomized trial in patients with "probable" MSA. The primary outcome was the change from baseline to week 12 in the mean total score of the Unified MSA Rating Scale (UMSARS Parts I + II). Secondary outcomes included change from baseline to week 6 in total UMSARS, and change from baseline to week 12 in the Scales for Outcomes in Parkinson Disease-Autonomic Dysfunction, Beck Depression Inventory, and different domains of the MSA-Quality of Life Questionnaire. Exploratory outcomes included change from baseline to week 12 in the UMSARS Parts I and II separately and change from baseline to week 24 in the total UMSARS score. Results: A total of 81 patients were randomly assigned, with no significant difference in the primary outcome (-2.13 units [95% confidence interval, CI, -4.55 to 0.29]; P = 0.08). There was a greater reduction on fluoxetine in the change from baseline to 12-week in UMSARS Part II (exploratory outcome: -1.41 units [95% CI, -2.84; 0.03]; p = 0.05) and in MSA-QoL emotional/social dimension (secondary outcome: -6.99 units [95% CI, -13.40; -0.56]; p < 0.03). A total of 5 deaths occurred (3 on fluoxetine and 2 on placebo). Conclusion: The MSA-FLUO failed to demonstrate fluoxetine superiority over placebo on the total UMSARS score, whereas trends in motor and emotional secondary/exploratory outcomes deserve further investigation.
Published: 2021
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35. Efficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental clinical cases

Author: Josep M. Antó, Nieves Pizarro Lozano, Tari Haahtela, Hubert Blain, Piotr Kuna, Rafael de la Torre, Arunas Valiulis, Torsten Zuberbier, Jean-Paul Cristol, Erik Melén, Jacques Reynes, Jean Bousquet, Alvaro A. Cruz, Wienczyslawa Czarlewski, Anna Bedbrook, Vincent Le Moing, Bolesław Samoliński, Ludger Klimek, Joaquim Mullol, Guido Iaccarino, Alessandro Fiocchi, Humboldt-Universität zu Berlin, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Euromov (EuroMov), Université de Montpellier (UM), AIR (AIR), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Universitat Pompeu Fabra [Barcelona] (UPF), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Advanced Biomedical Sciences, University of Naples Federico II, Vilnius Gediminas Technical University, CIBER de Epidemiología y Salud Pública (CIBERESP), Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Department of Dermatology, Allergology and Venereology, HUS Inflammation Center, Bousquet, J., Le Moing, V., Blain, H., Czarlewski, W., Zuberbier, T., de la Torre, R., Pizarro Lozano, N., Reynes, J., Bedbrook, A., Cristol, J. -P., Cruz, A. A., Fiocchi, A., Haahtela, T., Iaccarino, G., Klimek, L., Kuna, P., Melen, E., Mullol, J., Samolinski, B., Valiulis, A., Anto, J. M., Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), CHU Montpellier, Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Hospital del Mar Medical Research Institute [Barcelona, Spain] (IMIM), Federal University of Bahia, University of Helsinki, Center for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, University of Lódź, Karolinska Institutet [Stockholm], Universitat de Barcelona (UB), and Medical University of Warsaw - Poland
Subjects: MECHANISM, TRPV1, Transient receptor potential vanillin 1, SARS, Severe acute respiratory syndrome, VAS, Visual analogue scale, [SDV]Life Sciences [q-bio], Angiotensin II receptor type 1, COVID-19, Coronavirus 19 disease, TRPA1 Channel, AT1R, TRP, ACTIVATION, chemistry.chemical_compound, TRPA1, Transient receptor potential ankyrin 1, 0302 clinical medicine, Visual analogue scale, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Severe acute respiratory syndrome coronavirus 2, Medicine, Immunology and Allergy, 030223 otorhinolaryngology, Body mass index, Glucoraphanin, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, SULFORAPHANE, Fast onset, 3. Good health, Cough challenge, Severe acute respiratory syndrome, NAPQI, Coronavirus 19 disease, Transient receptor potential vanillin 1, Angiotensin converting enzyme, TRP, Transient receptor potential, Broccoli seed capsules, AT1R, Angiotensin II receptor type 1, lcsh:Immunologic diseases. Allergy, CHEMOPREVENTION, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), SARS-Cov-2, Transient receptor potential ankyrin 1, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Broccoli, Broccoli seed capsules, BMI, Body mass index, Nrf2, Nuclear factor (erythroid-derived 2)-like 2, TRPA1, Article, Nrf2, BMI, 03 medical and health sciences, Internal medicine, COVID-19, broccoli, cough challenge, TRPV1, STRATEGY, RICH, ACE, SARS, INDUCED CARDIOMYOPATHY, COUGH, Nuclear factor (erythroid-derived 2)-like 2, business.industry, Broccoli, RHINITIS, medicine.disease, ACE, Angiotensin converting enzyme, Clinical trial, 030228 respiratory system, chemistry, Transient receptor potential, 3121 General medicine, internal medicine and other clinical medicine, N-acetyl-p-benzoquinone imine, VAS, business, Cytokine storm, lcsh:RC581-607, NAPQI, N-acetyl-p-benzoquinone imine, SARS-Cov-2, Severe acute respiratory syndrome coronavirus 2, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: International audience; COVID-19 is described in a clinical case involving a patient who proposed the hypothesis that Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-interacting nutrients may help to prevent severe COVID-19 symptoms. Capsules of broccoli seeds containing glucoraphanin were being taken before the onset of SARS-CoV-2 infection and were continued daily for over a month after the first COVID-19 symptoms. They were found to reduce many of the symptoms rapidly and for a duration of 6-12 h by repeated dosing. When the patient was stable but still suffering from cough and nasal obstruction when not taking the broccoli capsules, a double-blind induced cough challenge confirmed the speed of onset of the capsules (less than 10 min). A second clinical case with lower broccoli doses carried out during the cytokine storm confirmed the clinical benefits already observed. A third clinical case showed similar effects at the onset of symptoms. In the first clinical trial, we used a dose of under 600 μmol per day of glucoraphanin. However, such a high dose may induce pharmacologic effects that require careful examination before the performance of any study. It is likely that the fast onset of action is mediated through the TRPA1 channel. These experimental clinical cases represent a proof-of-concept confirming the hypothesis that Nrf2-interacting nutrients are effective in COVID-19. However, this cannot be used in practice before the availability of further safety data, and confirmation is necessary through proper trials on efficacy and safety.
Published: 2021
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36. Interpersonal Synchronization Processes in Discrete and Continuous Tasks

Author: Hubert Blain, Samar Ezzina, Simon Pla, Didier Delignières, Clément Roume, Maxime Scotti, Euromov (EuroMov), Université de Montpellier (UM), CHU Montpellier, and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Subjects: Computer science, Cognitive Neuroscience, Distributed computing, 05 social sciences, Biophysics, Experimental and Cognitive Psychology, Interpersonal communication, Adaptation, Physiological, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Information processing theory, Cognition, Mutual adaptation, Synchronization (computer science), [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, 0501 psychology and cognitive sciences, Orthopedics and Sports Medicine, Interpersonal Relations, 030217 neurology & neurosurgery, ComputingMilieux_MISCELLANEOUS
Abstract: Three frameworks have been proposed to account for interpersonal synchronization: The information processing approach argues that synchronization is achieved by mutual adaptation, the coordination dynamics perspective supposes a continuous coupling between systems, and complexity matching suggests a global, multi-scale interaction. We hypothesized that the relevancy of these models was related to the nature of the performed tasks. 10 dyads performed synchronized tapping and synchronized forearm oscillations, in two conditions
Published: 2021
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37. Metacarpophalangeal joint instability in trapeziometacarpal osteoarthritis: A systematic review

Author: C. Lazerges, Léo Chiche, B. Degeorge, Bertrand Coulet, Michel Chammas, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Euromov (EuroMov), Université de Montpellier (UM), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Subjects: Joint Instability, Trapeziometacarpal osteoarthritis, Trapeziometacarpal, education, Osteoarthritis, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 030230 surgery, Thumb, Valgus, Metacarpophalangeal Joint, Métacarpo-phalangien, Thumb basal joint arthritis, 03 medical and health sciences, Metacarpophalangeal, 0302 clinical medicine, medicine, Humans, Arthrose, Orthopedics and Sports Medicine, Rhizarthrose, Orthodontics, Surgical repair, 030222 orthopedics, biology, business.industry, Rehabilitation, Metacarpophalangeal joint, medicine.disease, biology.organism_classification, humanities, body regions, medicine.anatomical_structure, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Surgery, Hyperextension, Trapézo-métacarpien, business, Algorithms
Abstract: International audience; Thumb metacarpophalangeal instability is commonly found in conjunction with trapeziometacarpal osteoarthritis. If not corrected, it can have detrimental effects on the outcome. The authors describe the two types of metacarpophalangeal deformities - hyperextension and valgus - their pathophysiology and the surgical repair techniques available to surgeons. An algorithm for treating this instability is presented.
Published: 2020
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38. Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

Author: Bousquet, Jean, Cristol, Jean-Paul, Czarlewski, Wienczyslawa, Anto, Josep M, Martineau, Adrian, Haahtela, Tari, Fonseca, Susana C, Iaccarino, Guido, Blain, Hubert, Fiocchi, Alessandro, Canonica, G Walter, Fonseca, Joao A, Vidal, Alain, Choi, Hak-Jong, Kim, Hyun Ju, Le Moing, Vincent, Reynes, Jacques, Sheikh, Aziz, Akdis, Cezmi A, Zuberbier, Torsten, Amir Hamzah Abdul Latiff, Baharudin, Abdullah, Werner, Aberer, Nancy, Abusada, Ian, Adcock, Alejandro, Afani, Ioana, Agache, Xenofon, Aggelidis, Jenifer, Agustin, Cezmi, A Akdis, Mübeccel, Akdis, Mona, Al-Ahmad, Abou Al-Zahab Bassam, Hussam, Alburdan, Oscar, Aldrey-Palacios, Emilio Alvarez Cuesta, Hiba Alwan Salman, Ashraf, Alzaabi, Salma, Amade, Gene, Ambrocio, Rosana, Angles, Isabella, Annesi-Maesano, Ignacio, J Ansotegui, Josep, M Anto, Paula Ara Bardajo, Stefania, Arasi, Margarete, Arrais, Hasan, Arshad, Maria-Cristina, Artesani, Estrella, Asayag, Francesca, Avolio, Khuzama, Azhari, Claus, Bachert, Diego, Bagnasco, Ilaria, Baiardini, Nissera, Bajrović, Petros, Bakakos, Sergio Bakeyala Mongono, Christine, Balotro-Torres, Sergio, Barba, Cristina, Barbara, Elsa, Barbosa, Bruno, Barreto, Joan, Bartra, Xavier, Basagana, Eric, D Bateman, Lkhagvaa, Battur, Anna, Bedbrook, Martín Bedolla Barajas, Bianca, Beghé, Antra, Bekere, Elizabeth, Bel, Ali Ben Kheder, Mikael, Benson, Elena-Camelia, Berghea, Karl-Christian, Bergmann, Roberto, Bernardini, David, Bernstein, Mike, Bewick, Slawomir, Bialek, Artur, Białoszewski, Thomas, Bieber, Nils, E Billo, Maria-Beatrice, Bilo, Carsten, Bindslev-Jensen, Leif, Bjermer, Hubert, Blain, Irina, Bobolea, Malgorzata Bochenska Marciniak, Christine, Bond, Attilio, Boner, Matteo, Bonini, Sergio, Bonini, Sinthia, Bosnic-Anticevich, Isabelle, Bosse, Sofia, Botskariova, Jacques, Bouchard, Louis-Philippe, Boulet, Rodolphe, Bourret, Philippe, Bousquet, Fulvio, Braido, Andrew, Briggs, Christopher, E Brightling, Jan, Brozek, Luisa, Brussino, Roland, Buhl, Roxana, Bumbacea, Rosalva, Buquicchio, María-Teresa Burguete Cabañas, Andrew, Bush, William, W Busse, Jeroen, Buters, Fernan, Caballero-Fonseca, Moïses, A Calderon, Mario, Calvo, Paulo, Camargos, Thierry, Camuzat, R Canevari, F, Antonio, Cano, G Walter Canonica, Arnaldo, Capriles-Hulett, Luis, Caraballo, Vicky, Cardona, Kai-Hakon, Carlsen, Jonas Carmona Pirez, Jorge, Caro, Warner, Carr, Pedro, Carreiro-Martins, Fredelita, Carreon-Asuncion, Ana-Maria, Carriazo, Carme Carrion, Y Ribas, Thomas, Casale, Mary-Ann, Castor, Elizabeth, Castro, G Caviglia, A, Lorenzo, Cecchi, Alfonso Cepeda Sarabia, Maciej, Chalubinski, Ramanathan, Chandrasekharan, Yoon-Seok, Chang, Victoria, Chato-Andeza, Lida, Chatzi, Christina, Chatzidaki, Niels, H Chavannes, Claudia Chaves Loureiro, Aurora-Alejandra Chavez Garcia, Marta, Chelninska, Yuzhi, Chen, Lei, Cheng, Sharon, Chinthrajah, Tomas, Chivato, Ekaterine, Chkhartishvili, George, Christoff, Henry, Chrystyn, Derek, K Chu, Antonio, Chua, Alexander, Chuchalin, Kian Fan Chung, Alberto, Cicerán, Cemal, Cingi, Giorgio, Ciprandi, Ieva, Cirule, Ana-Carla, Coelho, Enrico, Compalati, Jannis, Constantinidis, Jaime Correia de Sousa, Elisio Manuel Costa, David, Costa, María Del Carmen Costa Domínguez, André, Coste, Cottini, M, Linda, Cox, Carlos, Crisci, Maria Angiola Crivellaro, Alvaro, A Cruz, John, Cullen, Adnan, Custovic, Biljana, Cvetkovski, Wienczyslawa, Czarlewski, Gennaro, D'Amato, Jane da Silva, Ronald, Dahl, Sven-Erik, Dahlen, Vasilis, Daniilidis, Louei Darjazini Nahhas, Ulf, Darsow, Janet, Davies, Frédéric de Blay, Giulia De Feo, Eloisa De Guia, José-Ricardo De la Torre Navarrete, Chato De Los Santos, Esteban De Manuel Keenoy, Govert De Vries, Diana, Deleanu, Pascal, Demoly, Judah, Denburg, Philippe, Devillier, Alain, Didier, Sanja Dimic Janjic, Maria, Dimou, Anh Tuan Dinh-Xuan, Ratko, Djukanovic, Maria Do Ceu Texeira, Dejan, Dokic, Margarita Gabriela Domínguez Silva, Habib, Douagui, Nikolaos, Douladiris, Maria, Doulaptsi, Gérard, Dray, Ruta, Dubakiene, Eve, Dupas, Stephen, Durham, Marzia, Duse, Mark, Dykewicz, Didier, Ebo, Natalija, Edelbaher, Thomas, Eiwegger, Patrik, Eklund, Yehia, El-Gamal, Zeinab, A El-Sayed, Shereen, S El-Sayed, Magda, El-Seify, Regina, Emuzyte, Lourdes, Enecilla, Marina, Erhola, Heidilita, Espinoza, Jesús Guillermo Espinoza Contreras, John, Farrell, Lenora, Fernandez, Paola Fimbres Jimenez, Antje Fink Wagner, Alessandro, Fiocchi, Wytske, J Fokkens, Lenia, Folletti, Joao, A Fonseca, Jean-François, Fontaine, Francesco, Forastiere, Jose Miguel Fuentes Pèrez, Emily, Gaerlan-Resureccion, Mina, Gaga, José Luis Gálvez Romero, Amiran, Gamkrelidze, Alexis, Garcia, Cecilia Yvonne García Cobas, María de la Luz Hortensia García Cruz, Valeria Garcia Ortiz, Jacques, Gayraud, Matteo, Gelardi, Bilun, Gemicioglu, Dimitra, Gennimata, Sonya, Genova, José, Gereda, Roy Gerth van Wijk, Antonio, Giuliano, René-Maximiliano, Gomez, Miguel-Ange Gonzalez Ballester, Sandra González Diaz, Maia, Gotua, Christos, Grigoreas, Ineta, Grisle, Marta, Guidacci, Nick, Guldemond, Zdenek, Gutter, Antonieta, Guzmán, Tari, Haahtela, Ramsa, Halloum, David, Halpin, Eckard, Hamelmann, Suleiman, Hammadi, Richard, Harvey, Enrico, Heffler, Joachim, Heinrich, Adnan, Hejjaoui, Birthe, Hellquist-Dahl, Luiana Hernández Velázquez, Mark, Hew, Elham, Hossny, Peter, Howarth, Martin, Hrubiško, Yunuen Rocío Huerta Villalobos, Marc, Humbert, Salina, Husain, Michael, Hyland, Guido, Iaccarino, Moustafa, Ibrahim, Nataliya, Ilina, Maddalena, Illario, Cristoforo, Incorvaia, Antonio, Infantino, Carla, Irani, Zhanat, Ispayeva, Juan Carlos Ivancevich, Edgardo Ej Jares, Deborah, Jarvis, Ewa, Jassem, Klemen, Jenko, Rubén Darío Jiméneracruz Uscanga, Sebastian, L Johnston, Guy, Joos, Maja, Jošt, Kaja, Julge, Ki-Suck, Jung, Jocelyne, Just, Marek, Jutel, Igor, Kaidashev, Omer, Kalayci, Fuat, Kalyoncu, Jeni, Kapsali, Przemyslaw, Kardas, Jussi, Karjalainen, Carmela, A Kasala, Michael, Katotomichelakis, Loreta, Kavaliukaite, Kazi, S Bennoor, Thomas, Keil, Paul, Keith, Musa, Khaitov, Nikolai, Khaltaev, You-Young, Kim, Bruce, Kirenga, Jorg, Kleine-Tebbe, Ludger, Klimek, Fanny, W Ko, Bernard Koffi N'Goran, Evangelia, Kompoti, Peter, Kopač, Gerard, Koppelman, Anja Koren Jeverica, Seppo, Koskinen, Mitja, Košnik, Tomasz, Kostka, Kosta, V Kostov, Marek, L Kowalski, Tanya, Kralimarkova, Karmen Kramer Vrščaj, Helga, Kraxner, Samo, Kreft, Vicky, Kritikos, Dmitry, Kudlay, Mikael, Kuitunen, Inger, Kull, Piotr, Kuna, Maciej, Kupczyk, Violeta, Kvedariene, Marialena, Kyriakakou, Nika, Lalek, Massimo, Landi, Stephen, Lane, Désiree, E Larenas-Linnemann, Susanne, Lau, Daniel, Laune, Jorge, Lavrut, Lan, Le, Martina, Lenzenhuber, Gualtiero, Leo, Marcus, Lessa, Michael, Levin, Jing, Li, Philip, Lieberman, Giuseppe, Liotta, Brian, Lipworth, Xuandao, Liu, Rommel, Lobo, Karin, C Lodrup Carlsen, Carlo, Lombardi, Renaud, Louis, Stelios, Loukidis, Olga, Lourenço, Jorge, A Luna Pech, Bojan, Madjar, Enrico, Maggi, Antoine, Magnan, Bassam, Mahboub, Alpana, Mair, Anke-Hilse Maitland van der Zee, Mika, Makela, Michael, Makris, Hans-Jorgen, Malling, Mariana, Mandajieva, Patrick, Manning, Manolis, Manousakis, Pavlos, Maragoudakis, Gianluigi, Marseglia, Gailen, Marshall, Mohammad Reza Masjedi, Jorge, F Máspero, Juan José Matta Campos, Marcus, Maurer, Sandra, Mavale-Manuel, Cem, Meço, Erik, Melén, Giovanni, Melioli, Elisabete, Melo-Gomes, Eli, O Meltzer, Enrica, Menditto, Andrew, Menzies-Gow, Hans, Merk, Jean-Pierre, Michel, Yann, Micheli, Neven, Miculinic, Luís, Midão, Florin, Mihaltan, Nikolaos, Mikos, Manlio, Milanese, Branislava, Milenkovic, Dimitrios, Mitsias, Bassem, Moalla, Giuliana, Moda, María Dolores Mogica Martínez, Yousser, Mohammad, Frances-Montserrat, Moharra, Mostafa, Moin, Mathieu, Molimard, Isabelle, Momas, Monique, Mommers, Alessandro, Monaco, Stephen, Montefort, Lucia-Elvira, Montenegro, Riccardo, Monti, Dory, Mora, Mario, Morais-Almeida, Ralph, Mösges, Badr Eldin Mostafa, Joaquim, Mullol, Lars, Münter, Antonella, Muraro, Ruth, Murray, Antonio, Musarra, Tihomir, Mustakov, Robert, Naclerio, Kari, C Nadeau, Rachel, Nadif, Alla, Nakonechna, Leyla, Namazova-Baranova, Gretchen, Navarro-Locsin, Hugo, Neffen, Kristof, Nekam, Angelos, Neou, Eustachio, Nettis, Daniel, Neuberger, Laurent, Nicod, Stefania, Nicola, Verena, Niederberger-Leppin, Marek, Niedoszytko, Antonio, Nieto, Ettore, Novellino, Elizabete, Nunes, Dieudonné, Nyembue, Robyn, E O'Hehir, Cvetanka, Odjakova, Ken, Ohta, Yoshitaka, Okamoto, Kimi, Okubo, Brian, Oliver, Gabrielle, L Onorato, Maria Pia Orru, Solange, Ouédraogo, Kampadilemba, Ouoba, Francisco-Javier, Padilla, Pier Luigi Paggiaro, Aris, Pagkalos, Pajno, Giovanni Battista, Gianni, Pala, P Palaniappan, S, Isabella, Pali-Schöll, Susanna, Palkonen, Stephen, Palmer, Carmen Panaitescu Bunu, Petr, Panzner, Nikos, G Papadopoulos, Vasilis, Papanikolaou, Alberto, Papi, Bojidar, Paralchev, Giannis, Paraskevopoulos, Hae-Sim, Park, Giovanni, Passalacqua, Vincenzo, Patella, Ian, Pavord, Ruby, Pawankar, Soren, Pedersen, Susete, Peleve, Simona, Pellegino, Ana, Pereira, Mariana, Pereira, Tamara, Pérez, Andrea, Perna, Diego, Peroni, Oliver, Pfaar, Nhân, Pham-Thi, Bernard, Pigearias, Isabelle, Pin, Konstantina, Piskou, Constantinos, Pitsios, Davor, Plavec, Dagmar, Poethig, Wolfgang, Pohl, Antonija Poplas Susic, Todor, A Popov, Fabienne, Portejoie, Paul, Potter, Lars, Poulsen, Alexandra, Prados-Torres, Fotis, Prarros, David, Price, Emmanuel, Prokopakis, Francesca, Puggioni, Elisa, Puig-Domenech, Robert, Puy, Klaus, Rabe, Silvia, Rabotti, Filip, Raciborski, Josephine, Ramos, Cristina, Recalcati, Marysia, T Recto, Shereen, M Reda, Frederico, S Regateiro, Norbert, Reider, Sietze, Reitsma, Susana, Repka-Ramirez, Erminia, Ridolo, Janet, Rimmer, Daniela Rivero Yeverino, José Angelo Rizzo, Carlos, Robalo-Cordeiro, Graham, Roberts, Karen, Robles, Nicolas, Roche, Mónica Rodríguez González, Eréndira Rodríguez Zagal, Giovanni, Rolla, Christine, Rolland, Regina, Roller-Wirnsberger, Miguel Roman Rodriguez, Antonino, Romano, Jan, Romantowski, Philippe, Rombaux, Joel, Romualdez, Jose, Rosado-Pinto, Nelson, Rosario, Lanny, Rosenwasser, Oliviero, Rossi, Menachem, Rottem, Philip, W Rouadi, Nikoleta, Rovina, Irma Rozman Sinur, Mauricio, Ruiz, Lucy Tania Ruiz Segura, Dermot, Ryan, Hironori, Sagara, Daiki, Sakai, Daiju, Sakurai, Wafaa, Saleh, Johanna, Salimaki, Konstantinos, Samitas, Boleslaw, Samolinski, María Guadalupe Sánchez Coronel, Mario, Sanchez-Borges, Jaime, Sanchez-Lopez, Melissa, Sansonna, Codrut, Sarafoleanu, Faradiba Sarquis Serpa, Joaquin, Sastre, Eleonora, Savi, Agne, Savonyte, Bisher, Sawaf, Glenis, K Scadding, Sophie, Scheire, Peter, Schmid-Grendelmeier, Juan Francisco Schuhl, Holger, Schunemann, Maria, Schvalbová, Jorgen, Schwarze, Nicola, Scichilone, Gianenrico, Senna, Cecilia, Sepúlveda, Elie, Serrano, Sara, Shamai, Aziz, Sheikh, Mike, Shields, Vasil, Shishkov, Nikos, Siafakas, Alexander, Simeonov, Estelle Fer Simons, Juan Carlos Sisul, Brigita, Sitkauskiene, Ingelbjorg, Skrindo, Tanja Soklič Košak, Dirceu, Solé, Martin, Sondermann, Talant, Sooronbaev, Manuel, Soto-Martinez, Manuel, Soto-Quiros, Barnaro Sousa Pinto, Milan, Sova, Michael, Soyka, Krzysztof, Specjalski, Annette, Sperl, Otto, Spranger, Sofia, Stamataki, Lina, Stefanaki, Cristiana, Stellato, Rafael, Stelmach, Timo, Strandberg, Petra, Stute, Abirami, Subramaniam, Charlotte Suppli Ulrik, Michael, Sutherland, Silvia, Sylvestre, Aikaterini, Syrigou, Luis Taborda Barata, Nadejda, Takovska, Rachel, Tan, Frances, Tan, Vincent, Tan, Ing Ping Tang, Masami, Taniguchi, Line, Tannert, Pongsakorn, Tantilipikorn, Jessica, Tattersall, Filippo, Tesi, Uta, Thieme, Carel, Thijs, Mike, Thomas, Teresa, To, Ana Maria Todo-Bom, Alkis, Togias, Peter-Valentin, Tomazic, Vesna, Tomic-Spiric, Sanna, Toppila-Salmi, Maria-José Torres Jaen, Elina, Toskala, Massimo, Triggiani, Nadja, Triller, Katja, Triller, Ioanna, Tsiligianni, Uberti, M, Ruxandra, Ulmeanu, Jure, Urbancic, Marilyn Urrutia Pereira, Martina, Vachova, Felipe, Valdés, Rudolf, Valenta, Marylin Valentin Rostan, Antonio, Valero, Arunas, Valiulis, Mina, Vallianatou, Erkka, Valovirta, Michiel Van Eerd, Eric Van Ganse, Marianne van Hage, Olivier, Vandenplas, Tuula, Vasankari, Dafina, Vassileva, Cesar Velasco Munoz, Maria Teresa Ventura, Cécilia, Vera-Munoz, Frédéric, Viart, Dilyana, Vicheva, Pakit, Vichyanond, Petra, Vidgren, Giovanni, Viegi, Claus, Vogelmeier, Leena Von Hertzen, Theodoros, Vontetsianos, Dimitris, Vourdas, Vu Tran Thien Quan, Martin, Wagenmann, Samantha, Walker, Dana, Wallace, Yun De Wang, Susan, Waserman, Katrin, Wehner, Magnus, Wickman, Sian, Williams, Dennis, Williams, Nicola, Wilson, Gary, Wong, Kent, Woo, Lucyna, Wozniak, John, Wright, Piotr, Wroczynski, Paraskevi, Xepapadaki, Plamen, Yakovliev, Masao, Yamaguchi, Kwok, Yan, Yoke Yeow Yap, Mais, Yassin, Barbara, Yawn, Panayiotis, Yiallouros, Arzu, Yorgancioglu, Shigemi, Yoshihara, Ian, Young, Osman, B Yusuf, Asghar, Zaidi, Fares, Zaitoun, Petra, Zalud, Heather, Zar, T Zedda, M, Mario, E Zernotti, Luo, Zhang, Nanshan, Zhong, Mihaela, Zidarn, Torsten, Zuberbier, Celia, Zubrinich, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Humboldt University Of Berlin, Berlin Institute of Health (BIH), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), IMIM-Hospital del Mar, Generalitat de Catalunya, Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Barts & The London School of Medicine and Dentistry, Queen Mary University of London (QMUL), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Helsinki University Central Hospital [Finland] (HUCH), Departamento de Geociencias, Ambiente e Ordenamento do Territorio (DGAOT), Universidade do Porto = University of Porto, University of Naples Federico II = Università degli studi di Napoli Federico II, Euromov (EuroMov), Université de Montpellier (UM), IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Istituto Clinico Humanitas [Milan] (IRCCS Milan), Humanitas University [Milan] (Hunimed), Center of Research in Health Technologies and Information Systems (CINTESIS), AgroParisTech, World Institute of Kimchi [Gwangju], Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of Edinburgh, Universität Zürich [Zürich] = University of Zurich (UZH), Humboldt-Universität zu Berlin, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Helsinki, Universidade do Porto, University of Naples Federico II, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), MORNET, Dominique, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet J., Cristol J.-P., Czarlewski W., Anto J.M., Martineau A., Haahtela T., Fonseca S.C., Iaccarino G., Blain H., Fiocchi A., Canonica G.W., Fonseca J.A., Vidal A., Choi H.-J., Kim H.J., Le Moing V., Reynes J., Sheikh A., Akdis C.A., Zuberbier T., Abdul Latiff A.H., Abdullah B., Aberer W., Abusada N., Adcock I., Afani A., Agache I., Aggelidis X., Agustin J., Akdis M., Al-Ahmad M., Al-Zahab Bassam A., Alburdan H., Aldrey-Palacios O., Alvarez Cuesta E., Alwan Salman H., Alzaabi A., Amade S., Ambrocio G., Angles R., Annesi-Maesano I., Ansotegui I.J., Ara Bardajo P., Arasi S., Arrais M., Arshad H., Artesani M.-C., Asayag E., Avolio F., Azhari K., Bachert C., Bagnasco D., Baiardini I., Bajrovic N., Bakakos P., Bakeyala Mongono S., Balotro-Torres C., Barba S., Barbara C., Barbosa E., Barreto B., Bartra J., Basagana X., Bateman E.D., Battur L., Bedbrook A., Bedolla Barajas M., Beghe B., Bekere A., Bel E., Ben Kheder A., Benson M., Berghea E.-C., Bergmann K.-C., Bernardini R., Bernstein D., Bewick M., Bialek S., Bialoszewski A., Bieber T., Billo N.E., Bilo M.-B., Bindslev-Jensen C., Bjermer L., Bobolea I., Bochenska Marciniak M., Bond C., Boner A., Bonini M., Bonini S., Bosnic-Anticevich S., Bosse I., Botskariova S., Bouchard J., Boulet L.-P., Bourret R., Bousquet P., Braido F., Briggs A., Brightling C.E., Brozek J., Brussino L., Buhl R., Bumbacea R., Buquicchio R., Burguete Cabanas M.-T., Bush A., Busse W.W., Buters J., Caballero-Fonseca F., Calderon M.A., Calvo M., Camargos P., Camuzat T., Canevari F., Cano A., Canonican G.W., Capriles-Hulett A., Caraballo L., Cardona V., Carlsen K.-H., Carmona Pirez J., Caro J., Carr W., Carreiro-Martins P., Carreon-Asuncion F., Carriazo A.-M., CarrionyRibas C., Casale T., Castor M.-A., Castro E., Caviglia A.G., Cecchi L., Cepeda Sarabia A., Chalubinski M., Chandrasekharan R., Chang Y.-S., Chato-Andeza V., Chatzi L., Chatzidaki C., Chavannes N.H., Chaves Loureiro C., Chavez Garcia A.-A., Chelninska M., Chen Y., Cheng L., Chinthrajah S., Chivato T., Chkhartishvili E., Christoff G., Chrystyn H., Chu D.K., Chua A., Chuchalin A., Chung K.F., Ciceran A., Cingi C., Ciprandi G., Cirule I., Coelho A.-C., Compalati E., Constantinidis J., Correia de Sousa J., Costa E.M., Costa D., del Carmen Costa Dominguez M., Coste A., Cottini M., Cox L., Crisci C., Crivellaro M.A., Cruz A.A., Cullen J., Custovic A., Cvetkovski B., D'Amato G., da Silva J., Dahl R., Dahlen S.-E., Daniilidis V., Darjazini Nahhas L., Darsow U., Davies J., de Blay F., De Feo G., De Guia E., De la Torre Navarrete J.-R., De los Santos C., De Manuel Keenoy E., De Vries G., Deleanu D., Demoly P., Denburg J., Devillier P., Didier A., Dimic Janjic S., Dimou M., Dinh-Xuan A.T., Djukanovic R., Do Ceu Texeira M., Dokic D., Dominguez Silva M.G., Douagui H., Douladiris N., Doulaptsi M., Dray G., Dubakiene R., Dupas E., Durham S., Duse M., Dykewicz M., Ebo D., Edelbaher N., Eiwegger T., Eklund P., El-Gamal Y., El-Sayed Z.A., El-Sayed S.S., El-Seify M., Emuzyte R., Enecilla L., Erhola M., Espinoza H., Espinoza Contreras J.G., Farrell J., Fernandez L., Fimbres Jimenez P., Fink Wagner A., Fokkens W.J., Folletti L., Fontaine J.-F., Forastiere F., Fuentes Perez J.M., Gaerlan-Resureccion E., Gaga M., Galvez Romero J.L., Gamkrelidze A., Garcia A., Garcia Cobas C.Y., de la Luz Hortensia Garcia Cruz M., Ortiz V.G., Gayraud J., Gelardi M., Gemicioglu B., Gennimata D., Genova S., Gereda J., Gerth van Wijk R., Giuliano A., Gomez R.-M., Gonzalez Ballester M.-A., Gonzalez Diaz S., Gotua M., Grigoreas C., Grisle I., Guidacci M., Guldemond N., Gutter Z., Guzman A., Halloum R., Halpin D., Hamelmann E., Hammadi S., Harvey R., Heffler E., Heinrich J., Hejjaoui A., Hellquist-Dahl B., Hernandez Velazquez L., Hew M., Hossny E., Howarth P., Hrubisko M., Huerta Villalobos Y.R., Humbert M., Husain S., Hyland M., Ibrahim M., Ilina N., Illario M., Incorvaia C., Infantino A., Irani C., Ispayeva Z., Ivancevich J.C., Jares E.E., Jarvis D., Jassem E., Jenko K., Jimeneracruz Uscanga R.D., Johnston S.L., Joos G., Jost M., Julge K., Jung K.-S., Just J., Jutel M., Kaidashev I., Kalayci O., Kalyoncu F., Kapsali J., Kardas P., Karjalainen J., Kasala C.A., Katotomichelakis M., Kavaliukaite L., Bennoor K.S., Keil T., Keith P., Khaitov M., Khaltaev N., Kim Y.-Y., Kirenga B., Kleine-Tebbe J., Klimek L., Ko F.W., Koffi N'Goran B., Kompoti E., Kopac P., Koppelman G., Koren Jeverica A., Koskinen S., Kosnik M., Kostka T., Kostov K.V., Kowalski M.L., Kralimarkova T., Kramer Vrscaj K., Kraxner H., Kreft S., Kritikos V., Kudlay D., Kuitunen M., Kull I., Kuna P., Kupczyk M., Kvedariene V., Kyriakakou M., Lalek N., Landi M., Lane S., Larenas-Linnemann D.E., Lau S., Laune D., Lavrut J., Le L., Lenzenhuber M., Leo G., Lessa M., Levin M., Li J., Lieberman P., Liotta G., Lipworth B., Liu X., Lobo R., Lodrup Carlsen K.C., Lombardi C., Louis R., Loukidis S., Lourenco O., Luna Pech J.A., Madjar B., Maggi E., Magnan A., Mahboub B., Mair A., Maitland van der Zee A.-H., Makela M., Makris M., Malling H.-J., Mandajieva M., Manning P., Manousakis M., Maragoudakis P., Marseglia G., Marshall G., Masjedi M.R., Maspero J.F., Matta Campos J.J., Maurer M., Mavale-Manuel S., Meco C., Melen E., Melioli G., Melo-Gomes E., Meltzer E.O., Menditto E., Menzies-Gow A., Merk H., Michel J.-P., Micheli Y., Miculinic N., Midao L., Mihaltan F., Mikos N., Milanese M., Milenkovic B., Mitsias D., Moalla B., Moda G., Mogica Martinez M.D., Mohammad Y., Moharra F.-M., Moin M., Molimard M., Momas I., Mommers M., Monaco A., Montefort S., Montenegro L.-E., Monti R., Mora D., Morais-Almeida M., Mosges R., Mostafa B.E., Mullol J., Munter L., Muraro A., Murray R., Musarra A., Mustakov T., Naclerio R., Nadeau K.C., Nadif R., Nakonechna A., Namazova-Baranova L., Navarro-Locsin G., Neffen H., Nekam K., Neou A., Nettis E., Neuberger D., Nicod L., Nicola S., Niederberger-Leppin V., Niedoszytko M., Nieto A., Novellino E., Nunes E., Nyembue D., O'Hehir R.E., Odjakova C., Ohta K., Okamoto Y., Okubo K., Oliver B., Onorato G.L., Orru M.P., Ouedraogo S., Ouoba K., Padilla F.-J., Paggiaro P.L., Pagkalos A., Pajno G., Pala G., Palaniappan S., Pali-Scholl I., Palkonen S., Palmer S., Panaitescu Bunu C., Panzner P., Papadopoulos N.G., Papanikolaou V., Papi A., Paralchev B., Paraskevopoulos G., Park H.-S., Passalacqua G., Patella V., Pavord I., Pawankar R., Pedersen S., Peleve S., Pellegino S., Pereira A., Pereira M., Perez T., Perna A., Peroni D., Pfaar O., Pham-Thi N., Pigearias B., Pin I., Piskou K., Pitsios C., Plavec D., Poethig D., Pohl W., Poplas Susic A., Popov T.A., Portejoie F., Potter P., Poulsen L., Prados-Torres A., Prarros F., Price D., Prokopakis E., Puggioni F., Puig-Domenech E., Puy R., Rabe K., Rabotti S., Raciborski F., Ramos J., Recalcati C., Recto M.T., Reda S.M., Regateiro F.S., Reider N., Reitsma S., Repka-Ramirez S., Ridolo E., Rimmer J., Rivero Yeverino D., Rizzo J.A., Robalo-Cordeiro C., Roberts G., Robles K., Roche N., Rodriguez Gonzalez M., Rodriguez Zagal E., Rolla G., Rolland C., Roller-Wirnsberger R., Roman Rodriguez M., Romano A., Romantowski J., Rombaux P., Romualdez J., Rosado-Pinto J., Rosario N., Rosenwasser L., Rossi O., Rottem M., Rouadi P.W., Rovina N., Rozman Sinur I., Ruiz M., Ruiz Segura L.T., Ryan D., Sagara H., Sakai D., Sakurai D., Saleh W., Salimaki J., Samitas K., Samolinski B., Sanchez Coronel M.G., Sanchez-Borges M., Sanchez-Lopez J., Sansonna M., Sarafoleanu C., Sarquis Serpa F., Sastre J., Savi E., Savonyte A., Sawaf B., Scadding G.K., Scheire S., Schmid-Grendelmeier P., Schuhl J.F., Schunemann H., Schvalbova M., Schwarze J., Scichilone N., Senna G., Sepulveda C., Serrano E., Shamai S., Shields M., Shishkov V., Siafakas N., Simeonov A., Simons E.F., Sisul J.C., Sitkauskiene B., Skrindo I., Soklic Kosak T., Sole D., Sondermann M., Sooronbaev T., Soto-Martinez M., Soto-Quiros M., Pinto B.S., Sova M., Soyka M., Specjalski K., Sperl A., Spranger O., Stamataki S., Stefanaki L., Stellato C., Stelmach R., Strandberg T., Stute P., Subramaniam A., Suppli Ulrik C., Sutherland M., Sylvestre S., Syrigou A., Taborda Barata L., Takovska N., Tan R., Tan F., Tan V., Tang I.P., Taniguchi M., Tannert L., Tantilipikorn P., Tattersall J., Tesi F., Thieme U., Thijs C., Thomas M., To T., Todo-Bom A.M., Togias A., Tomazic P.-V., Tomic-Spiric V., Toppila-Salmi S., Torres Jaen M.-J., Toskala E., Triggiani M., Triller N., Triller K., Tsiligianni I., Uberti M., Ulmeanu R., Urbancic J., Urrutia Pereira M., Vachova M., Valdes F., Valenta R., Valentin Rostan M., Valero A., Valiulis A., Vallianatou M., Valovirta E., Van Eerd M., Van Ganse E., van Hage M., Vandenplas O., Vasankari T., Vassileva D., Velasco Munoz C., Ventura M.T., Vera-Munoz C., Viart F., Vicheva D., Vichyanond P., Vidgren P., Viegi G., Vogelmeier C., Von Hertzen L., Vontetsianos T., Vourdas D., Tran Thien Quan V., Wagenmann M., Walker S., Wallace D., De Wang Y., Waserman S., Wehner K., Wickman M., Williams S., Williams D., Wilson N., Wong G., Woo K., Wozniak L., Wright J., Wroczynski P., Xepapadaki P., Yakovliev P., Yamaguchi M., Yan K., Yap Y.Y., Yassin M., Yawn B., Yiallouros P., Yorgancioglu A., Yoshihara S., Young I., Yusuf O.B., Zaidi A., Zaitoun F., Zalud P., Zar H., Zedda M.T., Zernotti M.E., Zhang L., Zhong N., and Zidarn M.
Subjects: MAPK/ERK pathway, ARIA group, Allergy, [SDV]Life Sciences [q-bio], NF-KAPPA-B, debelost, Review, Pharmacology, Resveratrol, PROTECTS, chemistry.chemical_compound, 0302 clinical medicine, RESPIRATORY SYNDROME CORONAVIRUS, ENDOPLASMIC-RETICULUM STRESS, Medicine and Health Sciences, Immunology and Allergy, Medicine, OXIDATIVE STRESS, COVID-19, Foods, Insulin resistance, Nrf2, Nutrients, Obesity, TRPA1, 2. Zero hunger, 0303 health sciences, RESPIRATORY, INSULIN-RESISTANCE, Muscle cell proliferation, SULFORAPHANE, 3. Good health, [SDV] Life Sciences [q-bio], 030220 oncology & carcinogenesis, SIGNALING PATHWAY, Signal transduction, Life Sciences & Biomedicine, Pulmonary and Respiratory Medicine, NRF2 ACTIVATORS, MUSCLE-CELL PROLIFERATION, Immunology, 610 Medicine & health, Lung injury, Settore MED/10 - Malattie Dell'Apparato Respiratorio, ACUTE LUNG INJURY, 03 medical and health sciences, COVID-19, Foods, Insulin resistance, Nrf2, Nutrients, Obesity, TRPA1, udc:616.9, odpornost proti inzulinu, SULFORAPHANE PROTECTS, Transcription factor, PI3K/AKT/mTOR pathway, 030304 developmental biology, Science & Technology, business.industry, SARS-CoV-2, food, medicine.disease, chemistry, hranila, SYNDROME CORONAVIRUS, business, hrana, GREEN TEA
Abstract: There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
Published: 2020
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39. Accent-induced Modulation of Neural and Movement Patterns during Spontaneous Synchronization to Auditory Rhythms

Author: Peter E. Keller, Sylvie Nozaradan, Benoît G. Bardy, Simone Dalla Bella, Cécile J. Bouvet, Manuel Varlet, Euromov (EuroMov), and Université de Montpellier (UM)
Subjects: Movement (music), Cognitive Neuroscience, Movement, 05 social sciences, 050105 experimental psychology, Synchronization, Fingers, 03 medical and health sciences, [SCCO]Cognitive science, 0302 clinical medicine, Rhythm, Acoustic Stimulation, Modulation (music), Stress (linguistics), Time Perception, Auditory Perception, Humans, 0501 psychology and cognitive sciences, Psychology, Neuroscience, 030217 neurology & neurosurgery
Abstract: Human rhythmic movements spontaneously synchronize with auditory rhythms at various frequency ratios. The emergence of more complex relationships—for instance, frequency ratios of 1:2 and 1:3—is enhanced by adding a congruent accentuation pattern (binary for 1:2 and ternary for 1:3), resulting in a 1:1 movement–accentuation relationship. However, this benefit of accentuation on movement synchronization appears to be stronger for the ternary pattern than for the binary pattern. Here, we investigated whether this difference in accent-induced movement synchronization may be related to a difference in the neural tracking of these accentuation profiles. Accented and control unaccented auditory sequences were presented to participants who concurrently produced finger taps at their preferred frequency, and spontaneous movement synchronization was measured. EEG was recorded during passive listening to each auditory sequence. The results revealed that enhanced movement synchronization with ternary accentuation was accompanied by enhanced neural tracking of this pattern. Larger EEG responses at the accentuation frequency were found for the ternary pattern compared with the binary pattern. Moreover, the amplitude of accent-induced EEG responses was positively correlated with the magnitude of accent-induced movement synchronization across participants. Altogether, these findings show that the dynamics of spontaneous auditory–motor synchronization is strongly driven by the multi-time-scale sensory processing of auditory rhythms, highlighting the importance of considering neural responses to rhythmic sequences for understanding and enhancing synchronization performance.
Published: 2020
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40. La restauration de la complexité de la marche pour la prévention de la chute chez les personnes âgées : l’appariement des complexités

Author: Ezzina, Samar, Euromov (EuroMov), Université de Montpellier (UM), Université Montpellier, Didier Delignières, and Hubert Blain
Subjects: Elderly, Réhabilitation, [SHS.EDU]Humanities and Social Sciences/Education, Rehabilitation, Fall, Chute, Appariement des complexités, Complexity matching, Personnes âgées, Complexity, Complexité
Abstract: Today, falling is a major health problem for aging population. It generates a cascade of health complications such as dependence, social isolation, death, depression, etc. This doctoral work aimed to treat falling via an innovative framework: the theory of complex systems. First, we focus on interpersonal synchronization, i.e. the interaction between two complex systems, and we propose a new methodology to analyze this phenomenon. Next, we show that the complexity matching effect could represent a suitable approach for the study of interpersonal interaction. Therefore, in a second step, we propose a walking rehabilitation protocol based on the phenomenon of complexity matching and allowing to restore the complexity of the locomotion system in the elderly. We show that a regular training of 3 weeks in synchronized walking (elderly subject + young guide) can restore the complexity of walking in seniors (up to 2 months post-protocol). In addition, this restoration of complexity results in a reduction in the fear of falling and an improvement in the overall health of seniors.; La chute constitue, aujourd’hui, une problématique de santé majeure chez la population vieillissante. Elle, engendre une cascade de complications sanitaires tel que la dépendance, l’isolement social, le décès, la dépression, etc. Par conséquent, ce travail doctoral a visé de traiter la chute via une méthodologie innovante : la théorie des système complexes. Dans un premier temps, nous nous sommes intéressés à la synchronisation interpersonnelle, donc, l’interaction entre deux systèmes complexes, et nous proposons une nouvelle méthodologie pour analyser ce phénomène. Ensuite, nous montrons que l’appariement des complexités pourrait constituer une approche adaptée pour l’étude de l’interaction interpersonnelle. De ce fait, dans un second temps, nous proposons un protocole de réhabilitation à la marche basé sur un phénomène d’appariement des complexités permettant de restaurer la complexité du système de locomotion des personnes âgées. Nous montrons qu’un entraînement régulier de 3 semaines à la marche synchronisée (sujet âgé + guide jeune), permet de restaurer la complexité de la marche chez les seniors de manière pérenne (jusqu’à 2 mois post-protocole). De plus, cette restauration de la complexité obtenue se traduit par une diminution de la peur de chuter et une amélioration de l’état de santé global des seniors.
Published: 2020

41. Self-Quantification Systems to Support Physical Activity: From Theory to Implementation Principles

Author: Ines Di Loreto, Denis Mottet, Paul Dulaud, Euromov (EuroMov), Université de Montpellier (UM), TECHnologies pour la Coopération, l’Interaction et les COnnaissances dans les collectifs (Tech-CICO), Institut Charles Delaunay (ICD), and Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: behavior change, Computer science, Health Behavior, physical activity, lcsh:Medicine, Context (language use), Review, persuasive design, Hierarchical database model, Empirical research, Human–computer interaction, Humans, [INFO]Computer Science [cs], [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC], Exercise, user-centered design, ComputingMilieux_MISCELLANEOUS, User-centered design, Motivation, Hierarchy, model, User modeling, lcsh:R, Behavior change, health, mathematics_computer_science_other, algebra_number_theory, quantified self, support system, Physical Conditioning, Human, Decision analysis
Abstract: Since the emergence of the quantified self movement, users aim at health behavior change, but only those who are sufficiently motivated and competent with the tools will succeed. Our literature review shows that theoretical models for quantified self exist but they are too abstract to guide the design of effective user support systems. Here, we propose principles linking theory and implementation to arrive at a hierarchical model for an adaptable and personalized self-quantification system for physical activity support. We show that such a modeling approach should include a multi-factors user model (activity, context, personality, motivation), a hierarchy of multiple time scales (week, day, hour), and a multi-criteria decision analysis (user activity preference, user measured activity, external parameters). While implementation still poses many challenges, principles linking theory to implementation should facilitate the design of effective self-quantification systems. In this way, users who wish to improve their physical activity levels could be better supported.
Published: 2020
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42. Allograft-Composite Reverse Shoulder Arthroplasty for Malignant Tumor of the Proximal Humerus

Author: Michel Chammas, Alexandre Daumillare, Bertrand Coulet, Benjamin Degeorge, C. Lazerges, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and Euromov (EuroMov)
Subjects: medicine.medical_specialty, Proximal humerus, medicine.medical_treatment, Deltoid curve, Context (language use), Reverse shoulder, Bone Neoplasms, 03 medical and health sciences, 0302 clinical medicine, Deltoid muscle, medicine, Humans, Orthopedics and Sports Medicine, Rotator cuff, 030222 orthopedics, business.industry, Shoulder Joint, 030229 sport sciences, Humerus, Allografts, Arthroplasty, Surgery, medicine.anatomical_structure, Treatment Outcome, Arthroplasty, Replacement, Shoulder, Segmental resection, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Composite-allograft reverse shoulder arthroplasties are a surgical alternative in malignant tumor reconstructions following segmental bone resection of the proximal humerus. They allow reinsertion of the rotator cuff tendons and reliable restoration of humeral height, increasing prosthetic stability and mobility. Preoperative local tumor extension assessment must be thorough and a strict surgical technique must be followed to obtain satisfactory functional results. The indications for this procedure include a strictly intraosseous tumor of the proximal humerus corresponding to an S3-S4 A resection following criteria provided by the Musculoskeletal Tumor Society as described by Enneking and colleagues in 1990. Certain conditions must question the procedure such as extended S3-S4-S5 bone resections, partial sacrifice of the deltoid muscle, preoperative deltoid impairment, and glenohumeral arthrectomy. Here, we report technical details and indications of composite-allograft reverse shoulder arthroplasty in the context of tumor segmental resection of the proximal humerus, especially in the humeral preparation.
Published: 2020
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43. Effects of a highly intensive exercise-based intervention program (Sirocco) on prefrontal dorsolateral cortex activity and gait performance in patients with Parkinson's Disease: a pilot study

Author: HOANG, Isabelle, CHEMINON, Maxime, RANCHET, Maud, DEROLLEPOT, Romain, DEVOS, Hannes, Perrey, Stéphane, LUAUTE, Jacques, PAIRE-FICOUT, Laurence, DANAILA, Téodor, Laboratoire Ergonomie et Sciences Cognitives pour les Transports (TS2-LESCOT ), Université Gustave Eiffel, Hôpital Henry Gabrielle [CHU - HCL], Hospices Civils de Lyon (HCL), University of Kansas Medical Center [Lawrence], Euromov (EuroMov), Université de Montpellier (UM), and Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
Subjects: S DISEASE, [SCCO.NEUR]Cognitive science/Neuroscience, REHABILITATION PROGRAM, DUAL-TASK, PARKINSON&apos, MARCHE A PIED, DLPFC, MALADIE DE PARKINSON
Abstract: 11th World Congress for Neurorehabilitation , LYON, FRANCE, 07-/10/2020 - 10/10/2020; Question: Non-pharmacologic treatment such as physical exercise has been proven to have beneficial effects on gait disorders in Parkinson's disease (PD). In Lyon (France), Sirroco rehabilitation program is a novel, collective, multidisciplinary program focused on intensive, high amplitude movements, and loudness of speech for patients with PD. However, the effects of physical exercise on dorsolateral prefrontal cortex (DLPFC) activity in patients with PD is still elusive. The main aim of this pilot study was to assess the effects of the Sirocco program in patients with PD on DLPFC activity on single task (ST) and dual-task (DT) walking. Methods: Fourteen PD patients (mean: 66.9 y.o ± 8.1) completed Sirocco sessions for 5 weeks. Changes in oxyhemoglobin concentration (?HbO2) in the DLPFC were measured using functional Near Infrared Spectroscopy during three walking tasks conditions: (1) ST walking, (2) DT walking while counting forward and (3) DT walking while subtracting. Participants were assessed three times: five weeks before the program (T0); few days before (T1) and one week after the program (T2). Walking performance (mean stride time and cadence) was also recorded using foot-sensors. The gain in performance was calculated by subtracting values at T0 and T1 or at T2 and at T1. Results: Significant differences were observed in ?HbO2 between the three times only for the ST walking: ?HbO2 were significantly higher at T1 than at T0 whereas ?HbO2 was lower in T2 than in T1 (p
Published: 2020

44. Dorsolateral prefrontal activity during dual-task walking in patients with Parkinson's Disease

Author: RANCHET, Maud, HOANG, Isabelle, CHEMINON, Maxime, DEROLLEPOT, Romain, PERREY, Stéphane, LUAUTE, Jacques, Danaila, Teodor, PAIRE-FICOUT, Laurence, Laboratoire Ergonomie et Sciences Cognitives pour les Transports (TS2-LESCOT ), Université Gustave Eiffel, Hospices Civils de Lyon (HCL), Euromov (EuroMov), Université de Montpellier (UM), Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], PARACHUTE, EuroMov - Digital Health in Motion (Euromov DHM), IMT - MINES ALES (IMT - MINES ALES), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Montpellier (UM)
Subjects: S DISEASE, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, COGNITION, PARKINSON&apos, MARCHE A PIED, CORTICAL ACTIVITY, MALADIE DE PARKINSON, PARKINSON'S DISEASE, human activities, WALKING, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: WCNR, 11th World Congress for Neurorehabilitation, Lyon, FRANCE, 07-/10/2020 - 11/10/2020; 1.Question: Patients with Parkinson disease (PD) report difficulties walking while performing another task. Dual-task (DT) walking may therefore increase the risk of falls. To date, the effect of DT walking on brain activity is not well understood. The objective of this pilot study was to examine dorsolateral prefrontal cortex activity (DLPFC) during single-task (ST) and DT walking conditions in PD patients. 2.Methods: Thirteen patients with PD (mean age: 66 ± 7 years, 8 men, UPDRS motor score (/108): 23 ± 11, Montreal Cognitive Assessment (MoCA) score: 27 ± 2) and 13 healthy older adults (mean age: 64 ± 7 years, 8 men, MoCA score: 28 ± 3) performed three walking tasks: [1] ST walking, [2] DT walking while counting forward (+1) and [3] DT walking while subtracting (-7). Cortical activity in DLPFC, assessed by changes in oxy-haemoglobin (?HbO2) was measured using functional near infrared spectroscopy (NIRSport). Gait performance (speed, cadence and stride length) was recorded simultaneously using wearables sensors (Gait-Up sensors). 3. Results: In ST walking and DT walking while subtracting conditions, ?HbO2 was higher in patients than in controls (p < 0.05). No significant differences in ?HbO2 were found between ST and the two DT-walking conditions in patients whereas ?HbO2 was significantly higher in DT-walking conditions than in ST walking in controls. As expected, patients had reduced walking speed, cadence and stride length compared to controls, regardless of conditions (p < 0.05). Variability of their cadence increased as the walking task difficulty increased, which is not the case for controls. 4. Conclusion This pilot study suggests that dorsolateral prefrontal cortex plays a major role already during ST walking condition in patients in relatively early stages of PD. This may suggest that patients recruit additional cognitive resources, as a measure of cognitive compensation to perform the ST walking. These findings may have implications for rehabilitation of gait in patients with PD, improving automaticity in simple tasks. Another ongoing study will show the effect of an exercise-based intervention program (SIROCCO program) on DLPFC activity while walking in the same group of patients with PD.
Published: 2020

45. Is bilateral corticospinal connectivity impaired in patients with chronic obstructive pulmonary disease?

Author: Nelly Héraud, Alain Varray, Nicolas Oliver, Stéphane Perrey, Vincent Cabibel, François Alexandre, Euromov (EuroMov), Université de Montpellier (UM), Groupe 5 Santé [Lodève, France] (Les Cliniques du Souffle), and Les Cliniques du Souffle [Lodève, France]
Subjects: 0301 basic medicine, medicine.medical_specialty, Physiology, Vastus lateralis muscle, medicine.medical_treatment, Population, Corpus callosum, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, 0302 clinical medicine, Isometric Contraction, Internal medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Medicine, Muscle, Skeletal, education, ComputingMilieux_MISCELLANEOUS, education.field_of_study, Electromyography, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Motor Cortex, Muscle weakness, Evoked Potentials, Motor, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, 030104 developmental biology, medicine.anatomical_structure, Cardiology, Silent period, Primary motor cortex, medicine.symptom, business, 030217 neurology & neurosurgery, Motor cortex
Abstract: KEY POINTS During moderate and high levels of quadriceps force production, the ipsilateral motor cortex is concomitantly activated with the contralateral motor cortex throughout the corpus callosum to generate the motor command. Chronic obstructive pulmonary disease (COPD) patients display a structurally impaired corpus callosum that may explain the reduced motor command in this population, which in turn contributes to COPD-related muscle weakness of the knee extensors. The study aimed to determine whether bilateral connectivity was impaired and ipsilateral activation was lowered during unilateral strength production of the knee extensors. Our results indicate impaired bilateral connectivity but preserved ipsilateral activation in patients during unilateral isometric contractions of 50% of maximum voluntary strength. The preservation of ipsilateral activation during force production despite impaired bilateral connectivity is consistent with a reorganization of bilateral motor network function that drives unilateral strength production. ABSTRACT The contralateral primary motor cortex (M1) is not the only brain area implicated in motor command generation. During moderate and high levels of quadriceps force production, the ipsilateral M1 is concomitantly activated. Such activation is mediated by the corpus callosum, the main component of bilateral connectivity. Structural damage to the corpus callosum has been observed in chronic obstructive pulmonary disease (COPD) patients, which might reduce ipsilateral activation and contribute to the lower motor command associated with COPD muscle weakness. We thus aimed to determine whether bilateral connectivity and ipsilateral activation were impaired in COPD. Twenty-two COPD patients and 21 healthy age-matched controls were evaluated by transcranial magnetic stimulation, at rest and during 50% of maximal voluntary isometric contraction (MVIC) of the dominant vastus lateralis muscle. Bilateral connectivity was determined by the ipsilateral silent period (iSP) during 50% MVIC. Ipsilateral activation was determined as the increase in ipsilateral excitability from rest to 50% MVIC. As expected, COPD patients had significantly lower MVIC (-25%, p = 0.03). These patients also showed a significantly lower iSP (-53%, p
Published: 2020
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46. Rôle des interventions non-médicamenteuses pour vieillir en bonne santé

Author: Ninot, Gregory, Bernard, Pierre Louis, Nogues, Michel, Roslyakova, Tamila, Trouillet, Raphaël, Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université Paul-Valéry - Montpellier 3 (UPVM), Centre d’Evaluation des programmes de Prévention Sante [Montpellier] (Plateforme CEPS), Université de Montpellier (UM), and Euromov (EuroMov)
Subjects: [SDV]Life Sciences [q-bio]
Abstract: International audience; L’offre en interventions non médicamenteuses (INM) s’élargit continuellement pour les personnes de plus de 60 ans, aussi bien en prévention qu’en thérapeutique. Sélectionnées de manière empirique depuis des siècles ou apparues récemment à grand renfort d’études épigénétiques, d’essais cliniques et d’innovations technologiques, l’essor des INM s’amplifie et se diversifie dans le monde. Des questions résiduelles concernent 1) leur périmètre qui semble se recouper avec celui des médecines alternatives ; 2) leur évaluation qui semble impossible selon certains chercheurs ; et 3) leur mise en œuvre chez les personnes âgées qui semble trop contraignante. L’article répond à ces trois questions et présente ensuite des outils numériques développés par la Plateforme universitaire CEPS facilitant l’évaluation des INM dans le domaine du bien-vieillir. La mutation du système de santé, devenue nécessaire pour répondre aux besoins des baby-boomers, va élargir l’arsenal des solutions pertinentes pour la santé, leur combinaison dans une médecine et une approche de santé devenues personnalisées, compréhensives et intégratives. Les INM vont y jouer un rôle majeur au cours du siècle. Ces pratiques se distinguent des médecines alternatives, des messages généraux de santé publique et des offres socioculturelles par une recherche continue, une démarche qualité et une traçabilité des usages. Les INM constituent aujourd’hui un écosystème complémentaire des traitements biomédicaux dont la consolidation économique et juridique est croissante.
Published: 2020
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47. Guidance for the Prevention of the COVID-19 Epidemic in Long-Term Care Facilities: A Short-Term Prospective Study

Author: Yves Rolland, A. Ghisolfi, P. De Souto Barreto, Hubert Blain, H. Villars, A. De Mauleon, M.-H. Lacoste, Gérontopôle, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Euromov (EuroMov), Université de Montpellier (UM), Herrada, Anthony, and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse]
Subjects: Male, MESH: Health Facility Administration, 030309 nutrition & dietetics, MESH: Coronavirus Infections, Medicine (miscellaneous), Compartmentalization (information security), MESH: Long-Term Care, 0302 clinical medicine, prevention, Hygiene, Surveys and Questionnaires, Health care, MESH: COVID-19, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, media_common, 0303 health sciences, Nutrition and Dietetics, [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, MESH: Health Facilities, 3. Good health, long-term care facility, Primary Prevention, Scale (social sciences), MESH: Betacoronavirus, Medical emergency, France, Coronavirus Infections, guidance, MESH: Pandemics, Physician support, Coronavirus disease 2019 (COVID-19), media_common.quotation_subject, Pneumonia, Viral, Article, 03 medical and health sciences, Betacoronavirus, medicine, Humans, MESH: SARS-CoV-2, MESH: Surveys and Questionnaires, Pandemics, MESH: Humans, business.industry, SARS-CoV-2, COVID-19, medicine.disease, Long-Term Care, MESH: Prospective Studies, MESH: Male, MESH: France, Long-term care, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, MESH: Pneumonia, Viral, MESH: Primary Prevention, Health Facilities, Geriatrics and Gerontology, Health Facility Administration, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Background Guidance aiming at limiting the entry and spread of the COVID-19 have been widely communicated to Long-term Care Facilities (LTCFs). However, no clinical research has investigated their relevance. Objective Our objective was to compare the guidance applied for the prevention of the COVID-19 epidemic between the LTCFs having been contaminated by COVID-19 and LTCFs having not been contaminated. Methods A questionnaire was sent and systematically accompanied by phone call to the 132 LTCFs of Haute-Garonne (Occitania region, South-West of France). The questionnaire focused on the preventive measures implemented before March 23, 2020 (first LTCFs contaminated in this area). The questionnaire focused on physician support, implementation of usual guidance (eg, masks, hydro-alcoholic solute used), training on hygiene, containment in residents’ rooms and other distancing measures, use of temporary workers, compartmentalization within zones of residents and staff and a self-assessment analogic scale on the quality of the application of the preventive measures. We compared implementation of the guidance between the LTCFs with at least one case of COVID-19 among residents and/or health care professionals and LTCFs without COVID-19 case (between March 23rd and May 6th). Results 124 LTCFs participated (93.9%). 30 LTCFs (24.19%) were contaminated with COVID-19. Large heterogeneity of the application of the guidance was observed. Public LTCFs (OR= 0.39 (0.20–0.73), LTCFs which organized staff compartmentalization within zones (OR= 0.19 (0.07–0.48)), and LTCF with a staff who self-assessed a higher quality implementation of the preventive measures (OR= 0.65 (0.43–0.98)) were significantly more likely to avoid contamination by the COVID-19 outbreak. Conclusion Our study supports the relevance of guidance to prevent the entry of COVID-19, in particular the staff compartmentalization within zones, as well as the perception of the staff regarding the quality of implementation of those measures in LTCFs. Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s12603-020-1440-2 and is accessible for authorized users.
Published: 2020
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48. Validity of the Stryd Power Meter in Measuring Running Parameters at Submaximal Speeds

Author: Robin Candau, Stéphane Perrey, Romain Chailan, Frank Imbach, Euromov (EuroMov), Université de Montpellier (UM), Dynamique Musculaire et Métabolisme (DMEM), Université de Montpellier (UM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Seenovate, and 2018/0653 2018/0653
Subjects: Leg stiffness, force platform, lcsh:Sports, validity, [SDV]Life Sciences [q-bio], leg stiffness, Analyser, Bayesian analysis, Physical Therapy, Sports Therapy and Rehabilitation, 030229 sport sciences, 030204 cardiovascular system & hematology, Article, running power meter, Ground contact, 03 medical and health sciences, lcsh:GV557-1198.995, 0302 clinical medicine, Electricity meter, Statistics, Orthopedics and Sports Medicine, Bayesian framework, Force platform, Power output, Mathematics
Abstract: This study assessed the Stryd running power meter validity at sub-maximal speeds (8 to 19 km/h). Six recreational runners performed an incremental indoor running test. Power output (PO), ground contact time (GCT) and leg spring stiffness (LSS) were compared to reference measures recorded by portable metabolic analyser, force platforms and motion capture system. A Bayesian framework was conducted for systems validity and comparisons. We observed strong and positive linear relationships between Stryd PO and oxygen consumption ( R 2 = 0 . 82 , B F 10 &gt, 100 ), and between Stryd PO and external mechanical power ( R 2 = 0 . 88 , B F 10 &gt, 100 ). Stryd power meter underestimated PO ( B F 10 &gt, 100 ) whereas GCT and LSS values did not show any significant differences with the reference measures ( B F 10 = 0 . 008 , B F 10 = 0 . 007 , respectively). We conclude that the Stryd power meter provides valid measures of GCT and LSS but underestimates the absolute values of PO.
Published: 2020
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49. Efficacy of a Test-Retest Strategy in Residents and Health Care Personnel of a Nursing Home Facing a COVID-19 Outbreak

Author: Nadia Giacosa, Hubert Blain, Yves Rolland, Audrey Jaussent, Mylène Albrand, Jean Bousquet, Athanase Benetos, Edouard Tuaillon, Stéphanie Miot, CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Gérontopôle, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse], Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Gériatrie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Berlin Institute of Health (BIH), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), CCSD, Accord Elsevier, Euromov (EuroMov), Université de Montpellier (UM), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), and Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Subjects: Male, [SDV]Life Sciences [q-bio], rRT-PCR, Antibodies, Viral, Disease Outbreaks, 0302 clinical medicine, COVID-19 Testing, Health care, Outcome Assessment, Health Care, Infection control, Medicine, 030212 general & internal medicine, General Nursing, [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Health Policy, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, General Medicine, 3. Good health, Test (assessment), nursing home, Female, Patient Safety, medicine.symptom, Coronavirus Infections, medicine.medical_specialty, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Health Personnel, Pneumonia, Viral, RT-PCR, Real-Time Polymerase Chain Reaction, Asymptomatic, Article, 03 medical and health sciences, Internal medicine, Humans, antibodies against SARS-CoV-2, Pandemics, Occupational Health, Skilled Nursing Facilities, business.industry, Clinical Laboratory Techniques, Outbreak, COVID-19, Infectious Disease Transmission, Vertical, United States, Nursing Homes, DNA, Viral, Geriatrics and Gerontology, Contact Tracing, business, Nursing homes, 030217 neurology & neurosurgery
Abstract: Objective To assess the American Testing Guidance for Nursing Homes (NHs) - updated May 19, 2020 - with a new COVID-19 case. Design Case investigation. Setting and Subjects: All 79 residents and 34 Health Care Personnel (HCP) of a NH. Methods 7 days after identification of a COVID-19 resident, all residents and HCP underwent rRT-PCR testing for SARS-CoV-2 with nasopharyngeal swabs. This was repeated weekly in all previously negative subjects until the testing identified no new cases and in all positive subjects until the testing was negative. COVID-19 infection prevention and control (IPC) measures were implemented in all residents and HCP with positive testing or with COVID-19 symptoms. Standard IPC was also implemented in all HCP. Six weeks after initial testing, all residents underwent testing for ELISA-based IgG antibodies directed against the SARS-CoV-2. Symptoms were serially recorded in residents and HCP. Results 36 residents had a positive RT-PCR at baseline and two at day 7. Six HCP had a positive RT-PCR at baseline and two at day 7. No new COVID-19 cases were diagnosed later. Among the SARS-CoV-2-positive cases, six residents (16%) and three HCP (37%) were asymptomatic during the 14 days before testing. Twenty-five residents (92.3%) and all 8 HCP (100%) with a positive RT-PCR developed IgG antibodies against SARS-CoV-2. Among the residents and HCP always having tested negative, 2 (5%) and 5 (11.5%) developed IgG antibodies against SARS-CoV-2. These 2 residents had typical COVID-19 symptoms before and after testing and 2/5 HCP were asymptomatic before and after testing. Conclusions and Implications This study shows the validity of the updated American Testing Guidance for Nursing Homes (NHs). It suggests implementing COVID-19 IPC in both residents and HCP with positive testing or COVID-19 symptoms and warns that asymptomatic HCP with repeated negative RT-PCR testing can develop antibodies against SARS-CoV-2., A wide testing strategy is effective in detecting asymptomatic COVID-19 residents and HCP in a NH facing COVID-19 outbreak. Symptomatic residents and HCP as well as asymptomatic HCP with negative testing may also play a role in the virus spread within the NH.
Published: 2020
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50. Combining Internal- and External-Training-Loads to Predict Non-Contact Injuries in Soccer

Author: Jacky Montmain, Nicolas Sutton-Charani, Abdelhak Imoussaten, Stéphane Perrey, Emmanuel Vallance, Euromov (EuroMov), Université de Montpellier (UM), Informatique, Image, Intelligence Artificielle (I3A), Laboratoire de Génie Informatique et d'Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-IMT - MINES ALES (IMT - MINES ALES), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)
Subjects: [SPI.OTHER]Engineering Sciences [physics]/Other, Computer science, education, non-linear machine learning, Machine learning, computer.software_genre, well-being questionnaires, lcsh:Technology, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, Inertial measurement unit, Injury risk, General Materials Science, Instrumentation, lcsh:QH301-705.5, Fluid Flow and Transfer Processes, training load monitoring, Receiver operating characteristic, sport science, business.industry, lcsh:T, Process Chemistry and Technology, General Engineering, Training (meteorology), 030229 sport sciences, lcsh:QC1-999, Computer Science Applications, Tree (data structure), injury prediction, lcsh:Biology (General), lcsh:QD1-999, one-month and one-week time horizons, lcsh:TA1-2040, Injury data, Global Positioning System, Artificial intelligence, business, lcsh:Engineering (General). Civil engineering (General), Injury prediction, computer, 030217 neurology & neurosurgery, lcsh:Physics
Abstract: International audience; The large amount of features recorded from GPS and inertial sensors (external load) and well-being questionnaires (internal load) can be used together in a multi-dimensional non-linear machine learning based model for a better prediction of non-contact injuries. In this study we put forward the main hypothesis that the use of such models would be able to inform better about injury risks by considering the evolution of both internal and external loads over two horizons (one week and one month). Predictive models were trained with data collected by both GPS and subjective questionnaires and injury data from 40 elite male soccer players over one season. Various classification machine-learning algorithms that performed best on external and internal loads features were compared using standard performance metrics such as accuracy, precision, recall and the area under the receiver operator characteristic curve. In particular, tree-based algorithms based on non-linear models with an important interpretation aspect were privileged as they can help to understand internal and external load features impact on injury risk. For 1-week injury prediction, internal load features data were more accurate than external load features while for 1-month injury prediction, the best performances of classifiers were reached by combining internal and external load features.
Published: 2020
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