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1. Availability, accessibility, and use of green spaces and cognitive development in primary school children

Author

Fernandes, Amanda, Krog, Norun Hjertager, McEachan, Rosemary, Nieuwenhuijsen, Mark, Julvez, Jordi, Márquez, Sandra, de Castro, Montserrat, Urquiza, José, Heude, Barbara, Vafeiadi, Marina, Gražulevičienė, Regina, Slama, Rémy, Dedele, Audrius, Aasvang, Gunn Marit, Evandt, Jorunn, Andrusaityte, Sandra, Kampouri, Mariza, and Vrijheid, Martine

Published
2023
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2. Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis

Author

Neumann, Alexander, Walton, Esther, Alemany, Silvia, Cecil, Charlotte, González, Juan Ramon, Jima, Dereje D., Lahti, Jari, Tuominen, Samuli T., Barker, Edward D., Binder, Elisabeth, Caramaschi, Doretta, Carracedo, Ángel, Czamara, Darina, Evandt, Jorunn, Felix, Janine F., Fuemmeler, Bernard F., Gutzkow, Kristine B., Hoyo, Cathrine, Julvez, Jordi, Kajantie, Eero, Laivuori, Hannele, Maguire, Rachel, Maitre, Léa, Murphy, Susan K., Murcia, Mario, Villa, Pia M., Sharp, Gemma, Sunyer, Jordi, Raikkönen, Katri, Bakermans-Kranenburg, Marian, IJzendoorn, Marinus van, Guxens, Mònica, Relton, Caroline L., and Tiemeier, Henning

Published
2020
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3. Title. Availability, Accessibility, and Use of Green Spaces and Cognitive Development in Primary School Children

Author

Fernandes, Amanda, primary, Krog, Norun Hjertager, additional, Mceachan, Rosie, additional, Nieuwenhuijsen, Mark, additional, Julvez, Jordi, additional, Marquez, Sandra, additional, De Castro, Montserrat, additional, Urquiza, Jose, additional, Heude, Barbara, additional, Vafeiadi, Marina, additional, Gražulevičienė, Regina, additional, Slama, Rémy, additional, Dedele, Audrius, additional, Aasvang, Gunn Marit, additional, Evandt, Jorunn, additional, Andrusaityte, Sandra, additional, Kampouri, Mariza, additional, and Virjheid, Martine, additional

Published
2023
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5. Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries

Author

Julvez, Jordi, primary, López-Vicente, Mónica, additional, Warembourg, Charline, additional, Maitre, Lea, additional, Philippat, Claire, additional, Gützkow, Kristine B., additional, Guxens, Monica, additional, Evandt, Jorunn, additional, Andrusaityte, Sandra, additional, Burgaleta, Miguel, additional, Casas, Maribel, additional, Chatzi, Leda, additional, de Castro, Montserrat, additional, Donaire-González, David, additional, Gražulevičienė, Regina, additional, Hernandez-Ferrer, Carles, additional, Heude, Barbara, additional, Mceachan, Rosie, additional, Mon-Williams, Mark, additional, Nieuwenhuijsen, Mark, additional, Robinson, Oliver, additional, Sakhi, Amrit K., additional, Sebastian-Galles, Nuria, additional, Slama, Remy, additional, Sunyer, Jordi, additional, Tamayo-Uria, Ibon, additional, Thomsen, Cathrine, additional, Urquiza, Jose, additional, Vafeiadi, Marina, additional, Wright, John, additional, Basagaña, Xavier, additional, and Vrijheid, Martine, additional

Published
2021
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6. Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study

Author

Maitre, Léa, primary, Julvez, Jordi, additional, López-Vicente, Monica, additional, Warembourg, Charline, additional, Tamayo-Uria, Ibon, additional, Philippat, Claire, additional, Gützkow, Kristine B., additional, Guxens, Monica, additional, Andrusaityte, Sandra, additional, Basagaña, Xavier, additional, Casas, Maribel, additional, de Castro, Montserrat, additional, Chatzi, Leda, additional, Evandt, Jorunn, additional, Gonzalez, Juan R., additional, Gražulevičienė, Regina, additional, Smastuen Haug, Line, additional, Heude, Barbara, additional, Hernandez-Ferrer, Carles, additional, Kampouri, Mariza, additional, Manson, Dan, additional, Marquez, Sandra, additional, McEachan, Rosie, additional, Nieuwenhuijsen, Mark, additional, Robinson, Oliver, additional, Slama, Remy, additional, Thomsen, Cathrine, additional, Urquiza, Jose, additional, Vafeidi, Marina, additional, Wright, John, additional, and Vrijheid, Martine, additional

Published
2021
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7. DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Author

van Dongen, Jenny, Hagenbeek, Fiona A., Suderman, Matthew, Roetman, Peter J., Sugden, Karen, Chiocchetti, Andreas G., Ismail, Khadeeja, Mulder, Rosa H., Hafferty, Jonathan D., Adams, Mark J., Walker, Rosie M., Morris, Stewart W., Lahti, Jari, Küpers, Leanne K., Escaramis, Georgia, Alemany, Silvia, Jan Bonder, Marc, Meijer, Mandy, Ip, Hill F., Jansen, Rick, Baselmans, Bart M. L., Parmar, Priyanka, Lowry, Estelle, Streit, Fabian, Sirignano, Lea, Send, Tabea S., Frank, Josef, Jylhävä, Juulia, Wang, Yunzhang, Mishra, Pashupati Prasad, Colins, Olivier F., Corcoran, David L., Poulton, Richie, Mill, Jonathan, Hannon, Eilis, Arseneault, Louise, Korhonen, Tellervo, Vuoksimaa, Eero, Felix, Janine F., Bakermans-Kranenburg, Marian J., Campbell, Archie, Czamara, Darina, Binder, Elisabeth, Corpeleijn, Eva, Gonzalez, Juan R., Grazuleviciene, Regina, Gutzkow, Kristine B., Evandt, Jorunn, Vafeiadi, Marina, Klein, Marieke, van der Meer, Dennis, Ligthart, Lannie, Heijmans, Bastiaan T., ’t Hoen, Peter A. C., van Meurs, Joyce, Franke, Lude, Boomsma, Dorret I., Pool, René, Hottenga, Jouke J., van Greevenbroek, Marleen M. J., Stehouwer, Coen D. A., van der Kallen, Carla J. H., Schalkwijk, Casper G., Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H., van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Isaacs, Aaron, Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., van ’t Hof, Peter, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., ’t Hoen, Peter-Bram, Kluft, Cornelis, Davies, Gareth E., Hakulinen, Christian, Keltikangas-Järvinen, Liisa, Franke, Barbara, Freitag, Christine M., Konrad, Kerstin, Hervas, Amaia, Fernández-Rivas, Aranzazu, Vetro, Agnes, Raitakari, Olli, Lehtimäki, Terho, Vermeiren, Robert, Strandberg, Timo, Räikkönen, Katri, Snieder, Harold, Witt, Stephanie H., Deuschle, Michael, Pedersen, Nancy L., Hägg, Sara, Sunyer, Jordi, Kaprio, Jaakko, Ollikainen, Miina, Moffitt, Terrie E., Tiemeier, Henning, van IJzendoorn, Marinus H., Relton, Caroline, Vrijheid, Martine, Sebert, Sylvain, Jarvelin, Marjo-Riitta, Caspi, Avshalom, Evans, Kathryn L., McIntosh, Andrew M., Bartels, Meike, Child and Adolescent Psychiatry / Psychology, Pediatrics, Internal Medicine, Urology, Epidemiology, Orthopedics and Sports Medicine, Clinical Child and Family Studies, van der Kallen, Carla J. H., Schalkwijk, Casper G., Wijmenga, Cisca, Franke, Lude, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H., van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Isaacs, Aaron, Uitterlinden, André G., van Meurs, Joyce, Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., Jansen, Rick, van 't Hof, Peter, Deelen, Patrick, Nooren, Irene, 't Hoen, Peter A. C., Heijmans, Bastiaan T., Moed, Matthijs, Vermaat, Martijn, Luijk, René, Jan Bonder, Marc, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik W., 't Hoen, Peter-Bram, Boomsma, Dorret I., Pool, René, van Dongen, Jenny, Hottenga, Jouke J., van Greevenbroek, Marleen M. J., Stehouwer, Coen D. A., Institute for Molecular Medicine Finland, University of Helsinki, Doctoral Programme in Cognition, Learning, Instruction and Communication, Department of Psychology and Logopedics, Faculty of Medicine, Tellervo Korhonen / Principal Investigator, Genetic Epidemiology, Faculty Common Matters (Faculty of Medicine), Cognitive and Brain Aging, Helsinki Inequality Initiative (INEQ), Psychosocial factors and health, Faculty Common Matters (Faculty of Education), Medicum, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, Geriatrian yksikkö, Reproductive Origins of Adult Health and Disease (ROAHD), Life Course Epidemiology (LCE), Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Pediatric surgery, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), APH - Personalized Medicine, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Tampere University, Health Sciences, Department of Clinical Chemistry, Clinical Medicine, RS: MHeNs - R2 - Mental Health, and Psychiatrie & Neuropsychologie

Subjects
0301 basic medicine, Molecular biology, ADN, Physiology, CHILDREN, 3124 Neurology and psychiatry, Epigenesis, Genetic, Epigenome, 0302 clinical medicine, Child, RISK, ASSOCIATION, Middle Aged, Justice and Strong Institutions, Aggression, Psychiatry and Mental health, Schizophrenia, TWINS, Meta-analysis, Cord blood, Child, Preschool, DNA methylation, HEALTH, medicine.symptom, SMOKING, Adult, SDG 16 - Peace, Adolescent, 515 Psychology, Longevity, Biology, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, Young Adult, SDG 3 - Good Health and Well-being, Genetic variation, medicine, Genetics, Humans, ddc:610, EXPOSURE, ABUSE, Genetic association, Aged, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], SDG 16 - Peace, Justice and Strong Institutions, 3112 Neurosciences, GENOME-WIDE, DNA Methylation, Epigenètica, medicine.disease, 3141 Health care science, 030104 developmental biology, COHORT PROFILE, 1182 Biochemistry, cell and molecular biology, CpG Islands, 3111 Biomedicine, Metaanàlisi, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Molecular psychiatry 26(6), 2148-2162 (2021). doi:10.1038/s41380-020-00987-x, Published by Macmillan, London

Published
2021

8. Early Life Multiple Exposures and Child Cognitive Function: A Multi-Centric Birth Cohort Study in Six European Countries

Author

Julvez, Jordi, primary, López-Vicente, Mònica, additional, Warembourg, Charline, additional, Maitre, Lea, additional, Philippat, Claire, additional, B. Gützkow, Kristine, additional, Guxens, Mònica, additional, Evandt, Jorunn, additional, Andrusaityte, Sandra, additional, Burgaleta, Miguel, additional, Casas, Maribel, additional, Chatzi, Leda, additional, de Castro, Montserrat, additional, Donaire-González, David, additional, Gražulevičienė, Regina, additional, Hernandez-Ferrer, Carles, additional, Heude, Barbara, additional, Mceachan, Rosie, additional, Mon-Williams, Mark, additional, Nieuwenhuijsen, Mark, additional, Robinson, Oliver, additional, Sakhi, Amrit K., additional, Sebastian-Galles, Núria, additional, Slama, Remy, additional, Sunyer, Jordi, additional, Tamayo-Uria, Ibon, additional, Thomsen, Cathrine, additional, Urquiza, Jose, additional, Vafeiadi, Marina, additional, Wright FRCP, John, additional, Basagaña, Xavier, additional, and Vrijheid, Martine, additional

Published
2020
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9. Association between DNA methylation and ADHD symptoms from birth to school age: A prospective meta-analysis

Author

Neumann, Alexander, primary, Walton, Esther, additional, Alemany, Silvia, additional, Cecil, Charlotte, additional, González, Juan Ramon, additional, Jima, Dereje D., additional, Lahti, Jari, additional, Tuominen, Samuli T., additional, Barker, Edward D., additional, Binder, Elisabeth, additional, Caramaschi, Doretta, additional, Carracedo, Ángel, additional, Czamara, Darina, additional, Evandt, Jorunn, additional, Felix, Janine F., additional, Fuemmeler, Bernard F., additional, Gutzkow, Kristine B., additional, Hoyo, Cathrine, additional, Julvez, Jordi, additional, Kajantie, Eero, additional, Laivuori, Hannele, additional, Maguire, Rachel, additional, Maitre, Léa, additional, Murphy, Susan K., additional, Murcia, Mario, additional, Villa, Pia M., additional, Sharp, Gemma, additional, Sunyer, Jordi, additional, Raikkönen, Katri, additional, Bakermans-Kranenburg, Marian, additional, van IJzendoorn, Marinus, additional, Guxens, Mònica, additional, Relton, Caroline L., additional, and Tiemeier, Henning, additional

Published
2019
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11. Human Early Life Exposome (HELIX) study: a European population-based exposome cohort

Author

Maitre, Léa, De Bont, Jeroen, Casas, Maribel, Robinson, Oliver, Aasvang, Gunn Marit, Agier, Lydiane, Andrušaitytė, Sandra, Ballester, Ferrán, Basagaña, Xavier, Borrás, Eva, Brochot, Céline, Bustamante, Mariona, Carracedo, Angel, De Castro, Montserrat, Dedele, Audrius, Donaire González, David, Estivill, Xavier, Evandt, Jorunn, Fossati, Serena, Giorgis Allemand, Lise, Granum, Berit, Grazuleviciene, Regina, Gützkow, Kristine Bjerve, Småstuen Haug, Line, Hernández Ferrer, Carles, Heude, Barbara, Ibarluzea Maurolagoitia, Jesús María, Julvez, Jordi, Karachaliou, Marianna, Keun, Hector C, Hjertager Krog, Norun, Lau, Chung-Ho E., Leventakou, Vasiliki, Lyon Caen, Sarah, Manzano, Cyntia, Mason, Dan, McEachan, Rosemary, Meltzer, Helle Margrete, Petraviciene, Inga, Quentin, Joane, Roumeliotaki, Theano, Sabido, Eduard, Saulnier, Pierre-Jean, Siskos, Alexandros P, Siroux, Valérie, Sunyer, Jordi, Tamayo, Ibon, Urquiza, Jose, Vafeiadi, Marina, Van Gent, Diana, Vives Usano, Marta, Waiblinger, Dagmar, Warembourg, Charline, Chatzi, Leda, Coen, Muireann, Van den Hazel, Peter, Nieuwenhuijsen, Mark J., Slama, Rémy, Thomsen, Cathrine, Wright, John, Vrijheid, Martine, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Norwegian Institute of Public Health [Oslo] (NIPH), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU), Universitat de València (UV), Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne] (FISABIO), Centre for Genomic Regulation [Barcelona] (CRG), Universitat Pompeu Fabra [Barcelona] (UPF)-Centro Nacional de Analisis Genomico [Barcelona] (CNAG), Institut National de l'Environnement Industriel et des Risques (INERIS), Universidade de Santiago de Compostela [Spain] (USC ), CIBER de Enfermedades Raras (CIBERER), Sidra Medicine [Doha, Qatar], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), BIODonostia Research Institute, Public Health Division of Gipuzkoa, University of Crete [Heraklion] (UOC), Imperial College London, CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Harvard University [Cambridge], Keck School of Medicine [Los Angeles], University of Southern California (USC), Maastricht University [Maastricht], Veiligheids-en Gezondheidsregio Gelderland Midden [Arnhem, the Netherlands] (VGGM), Civs, Gestionnaire, Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Commission of the European Communities, Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría, Universidade de Santiago de Compostela. Instituto de Ciencias Forenses 'Luis Concheiro'(INCIFOR), RS: NUTRIM - R3 - Respiratory & Age-related Health, and Complexe Genetica

Subjects
Male, Urban Population, Epidemiology, Blood Pressure, 01 natural sciences, 0302 clinical medicine, USE REGRESSION-MODELS, Prospective Studies, profile, education.field_of_study, Anthropometry, public health, birth cohort, General Medicine, 3. Good health, MOTHER, Child, Preschool, Prenatal Exposure Delayed Effects, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Cohort, Body Composition, HEALTH, Food Hypersensitivity, Birth cohort, medicine.medical_specialty, Exposome, exposome, 03 medical and health sciences, land-use, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, Humans, education, Psychological Tests, child cohort, Public health, areas, Infant, Environmental Exposure, AIR-POLLUTION, DNA Methylation, Omics, medicine.disease, CHILD COHORT, exposure, Attention Deficit Disorder with Hyperactivity, Biomarkers, Proteome, Salut Pública, Neurodevelopment, use regression-models, 010501 environmental sciences, AREAS, 11. Sustainability, 030212 general & internal medicine, Prospective cohort study, mother, Smoking, Community child health, health, omics, Respiratory Function Tests, [SDV.TOX] Life Sciences [q-bio]/Toxicology, Europe, PREGNANCY, Exposoma, Blood pressure, Metabolome, epidemiology, Female, pregnancy, community child health, Adult, Population, Mothers, PROFILE, Childhood obesity, Hazardous Substances, Young Adult, Environmental health, medicine, air-pollution, Body Weights and Measures, EXPOSURE, 0105 earth and related environmental sciences, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, LAND-USE, business.industry, Respiratory health, Infant, Newborn, HELIX, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Gene-Environment Interaction, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, European population, business, Transcriptome
Abstract

Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations. Participants The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6-11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). Findings to date Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6-11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder. Future plans HELIX study results will inform on the early life exposome and its association with molecular omics signatures and child health outcomes. Cohort data are accessible for future research involving researchers external to the project. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-206) under grant agreement no 308333-the HELIX project. Dr Maribel Casas and Dr Jordi Julvez received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128, MS14/00108). INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, the Conselleria de Sanitat, Generalitat Valenciana, Department of Health of the Basque Government; the Provincial Government of Gipuzkoa, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Norwegian Mother and Child Cohort Study (MoBa) is supported by the Norwegian Ministry of Health and the Ministry of Education and Research, NIH/NIEHS (contract no. N01-ES-75558), and NIH/NINDS (grant no. 1 UO1 NS 047537-01 and grant no. 2 UO1 NS 047537-06A1). The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children, in Heraklion district, Crete, Greece: 2011-2014; 'Rhea Plus': Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-2015). The work was also supported by MICINN (MTM2015-68140-R) and Centro Nacional de Genotipado-CEGEN-PRB2-ISCIII. CW received funding from the Fondation de France.

Published
2018

13. Additional file 1: Figure S1. of Road traffic noise and registry based use of sleep medication

Author

Evandt, Jorunn, Oftedal, Bente, Norun Krog, Skurtveit, Svetlana, Nafstad, Per, Schwarze, Per, Skovlund, Eva, Houthuijs, Danny, and Aasvang, Gunn

Abstract

Simplified directed acyclic graph for the association between road traffic noise and sleep medication use. Some variables have been grouped for legibility. a Includes the variables age, sex, and having children â ¤ 5 years b Includes the variables education and household income c Includes the variables smoking status, alcohol use, caffeine use, physical activity, and night shift work. (DOCX 64 kb)

Published
2017
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17. Social inequalities in road traffic noise exposure

Author

Sygna Karin, Oftedal Bente, Hjertager Krog Norun, Aamodt Geir, Evandt Jorunn, and Aasvang Gunn Marit

Subjects
Noise, Noise exposure, Public economics, Social gradient, Economics, General Earth and Planetary Sciences, Social inequality, Road traffic, General Environmental Science
Abstract

Background It is well known that there is a social gradient in health. It is not a single explanation of social inequalities in health, but housing seems to be an important factor. In order to prev...

Published
2013

20. DNA methylation signatures of a broad spectrum of aggressive behavior: a meta-analysis of epigenome-wide studies across the lifespan

Author

Dongen, Jenny, Hagenbeek, Fiona A., Suderman, Matthew, Roetman, Peter, Sugden, Karen, Chiocchetti, Andreas G., Ismail, Khadeeja, Mulder, Rosa H., Hafferty, Jonathan, Adams, Mark J., Walker, Rosie M., Morris, Stewart W., Lahti, Jari, Kupers, Leanne K., Escaramis, Georgia, Alemany, Silvia, Bonder, Marc Jan, Meijer, Mandy, Ip, Hill F., Jansen, Rick, Baselmans, Bart M. L., Parmar, Priyanka, Lowry, Estelle, Streit, Fabian, Sirignano, Lea, Send, Tabea, Frank, Josef, Jylhava, Juulia, Wang, Yunzhang, Mishra, Pashupati Prasad, Colins, Olivier F., Corcoran, David, Poulton, Richie, Jonathan Mill, Hannon, Eilis J., Arseneault, Louise, Korhonen, Tellervo, Vuoksimaa, Eero, Felix, Janine, Bakermans-Kranenburg, Marian, Campbell, Archie, Czamara, Darina, Binder, Elisabeth, Corpeleijn, Eva, Ramon Gonzalez, Juan, Grazuleviciene, Regina, Gutzkow, Kristine B., Evandt, Jorunn, Vafeiadi, Marina, Klein, Marieke, Meer, Dennis, Ligthart, Lannie, Kluft, Cornelis, Davies, Gareth E., Hakulinen, Christian, Keltikangas-Jarvinen, Liisa, Franke, Barbara, Freitag, Christine M., Konrad, Kerstin, Hervas, Amaia, Fernandez-Rivas, Aranzazu, Vetro, Agnes, Raitakari, Olli, Lehtimaki, Terho, Vermeiren, Robert, Strandberg, Timo, Raikkonen, Katri, Snieder, Harold, Witt, Stephanie H., Deuschle, Michael, Pedersen, Nancy L., Hagg, Sara, Sunyer, Jordi, Franke, Lude, Kaprio, Jaakko, Ollikainen, Miina, Moffitt, Terrie E., Tiemeier, Henning, Ijzendoorn, Marinus H., Relton, Caroline, Vrijheid, Martine, Sebert, Sylvain, Jarvelin, Marjo-Riitta, Caspi, Avshalom, Evans, Kathryn L., Mcintosh, Andrew M., Bartels, Meike, Boomsma, Dorret, Biological Psychology, APH - Mental Health, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, APH - Methodology, and Amsterdam Reproduction & Development

21. Urban environment and health behaviours in children from six European countries.

Author

Fernández-Barrés, Sílvia, Robinson, Oliver, Fossati, Serena, Márquez, Sandra, Basagaña, Xavier, de Bont, Jeroen, de Castro, Montserrat, Donaire-Gonzalez, David, Maitre, Léa, Nieuwenhuijsen, Mark, Romaguera, Dora, Urquiza, José, Chatzi, Leda, Iakovides, Minas, Vafeiadi, Marina, Grazuleviciene, Regina, Dedele, Audrius, Andrusaityte, Sandra, Marit Aasvang, Gunn, and Evandt, Jorunn

Subjects
*HEALTH behavior, *URBAN health, *NORMALIZED difference vegetation index, *CHILDREN'S health, *SEDENTARY behavior, *SCHOOL children, *ENVIRONMENTAL exposure, *DWELLINGS
Abstract

Urban environmental design is increasingly considered influential for health and wellbeing, but evidence is mostly based on adults and single exposure studies. We evaluated the association between a wide range of urban environment characteristics and health behaviours in childhood. We estimated exposure to 32 urban environment characteristics (related to the built environment, traffic, and natural spaces) for home and school addresses of 1,581 children aged 6–11 years from six European cohorts. We collected information on health behaviours including total amount of overall moderate-to-vigorous physical activity, physical activity outside school hours, active transport, sedentary behaviours and sleep duration, and developed patterns of behaviours with principal component analysis. We used an exposure-wide association study to screen all exposure-outcome associations, and the deletion-substitution-addition algorithm to build a final multi-exposure model. In multi-exposure models, green spaces (Normalized Difference Vegetation Index, NDVI) were positively associated with active transport, and inversely associated with sedentary time (22.71 min/day less (95 %CI −39.90, −5.51) per interquartile range increase in NDVI). Residence in densely built areas was associated with more physical activity and less sedentary time, and densely populated areas with less physical activity outside school hours and more sedentary time. Presence of a major road was associated with lower sleep duration (-4.80 min/day (95 %CI −9.11, −0.48); compared with no major road). Results for the behavioural patterns were similar. This multicohort study suggests that areas with more vegetation, more building density, less population density and without major roads are associated with improved health behaviours in childhood. [ABSTRACT FROM AUTHOR]

Published
2022
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22. DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan.

Author

van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, Walker RM, Morris SW, Lahti J, Küpers LK, Escaramis G, Alemany S, Jan Bonder M, Meijer M, Ip HF, Jansen R, Baselmans BML, Parmar P, Lowry E, Streit F, Sirignano L, Send TS, Frank J, Jylhävä J, Wang Y, Mishra PP, Colins OF, Corcoran DL, Poulton R, Mill J, Hannon E, Arseneault L, Korhonen T, Vuoksimaa E, Felix JF, Bakermans-Kranenburg MJ, Campbell A, Czamara D, Binder E, Corpeleijn E, Gonzalez JR, Grazuleviciene R, Gutzkow KB, Evandt J, Vafeiadi M, Klein M, van der Meer D, Ligthart L, Kluft C, Davies GE, Hakulinen C, Keltikangas-Järvinen L, Franke B, Freitag CM, Konrad K, Hervas A, Fernández-Rivas A, Vetro A, Raitakari O, Lehtimäki T, Vermeiren R, Strandberg T, Räikkönen K, Snieder H, Witt SH, Deuschle M, Pedersen NL, Hägg S, Sunyer J, Franke L, Kaprio J, Ollikainen M, Moffitt TE, Tiemeier H, van IJzendoorn MH, Relton C, Vrijheid M, Sebert S, Jarvelin MR, Caspi A, Evans KL, McIntosh AM, Bartels M, and Boomsma DI

Subjects
Adolescent, Adult, Aged, Aggression, Child, Child, Preschool, CpG Islands genetics, Epigenesis, Genetic genetics, Genome-Wide Association Study, Humans, Longevity, Middle Aged, Young Adult, DNA Methylation genetics, Epigenome
Abstract

DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 × 10 -7 ; Bonferroni correction). In cord blood samples of 2425 children from five cohorts with aggression assessed at mean ages ranging from 4 to 7 years, 83% of these sites showed the same direction of association with childhood aggression (r = 0.74, p = 0.006) but no epigenome-wide significant sites were found. Top-sites (48 at a false discovery rate of 5% in the peripheral blood meta-analysis or in a combined meta-analysis of peripheral blood and cord blood) have been associated with chemical exposures, smoking, cognition, metabolic traits, and genetic variation (mQTLs). Three genes whose expression levels were associated with top-sites were previously linked to schizophrenia and general risk tolerance. At six CpGs, DNA methylation variation in blood mirrors variation in the brain. On average 44% (range = 3-82%) of the aggression-methylation association was explained by current and former smoking and BMI. These findings point at loci that are sensitive to chemical exposures with potential implications for neuronal functions. We hope these results to be a starting point for studies leading to applications as peripheral biomarkers and to reveal causal relationships with aggression and related traits., (© 2021. The Author(s).)

Published
2021
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