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1,755 results on '"Evans, Kathryn"'

1. LIGHT HOUSE: A century-old Missouri grande dame warms up--and wows--with an unlikely muse

Author

O'Shea-Evans, Kathryn

Subjects
Interior designers -- Practice, Mansions -- Decoration and finishing, Architecture and design industries, Home and garden, Home furnishings industry
Abstract

IT'S RARE FOR WINDOWS TO INSPIRE a color palette, but in this Kansas City, Missouri, home, they're equivalent to a Grant Wood painting, complete with stained glass motifs that summon [...]

Published
2024

2. Riding High: Equestrian pursuits and refined outdoor spaces take center stage in this inviting Wellington, Florida, Home

Author

O'Shea-Evans, Kathryn

Subjects
Wellington, Florida -- Buildings and facilities -- Social aspects, Interior design -- Methods, Dwellings -- Decoration and finishing, Housing -- Decoration and finishing, Architecture and design industries, Home and garden, Home furnishings industry
Abstract

WHEN A NEW YORK based family decided to build a ground-up getaway home in Wellington for trips with their daughters--both competitive equestrians--designer Tom Scheerer looked to the sport as his [...]

Published
2024

4. Cardiogenic control of affective behavioural state

Author

Hsueh, Brian, Chen, Ritchie, Jo, YoungJu, Tang, Daniel, Raffiee, Misha, Kim, Yoon Seok, Inoue, Masatoshi, Randles, Sawyer, Ramakrishnan, Charu, Patel, Sneha, Kim, Doo Kyung, Liu, Tony X, Kim, Soo Hyun, Tan, Longzhi, Mortazavi, Leili, Cordero, Arjay, Shi, Jenny, Zhao, Mingming, Ho, Theodore T, Crow, Ailey, Yoo, Ai-Chi Wang, Raja, Cephra, Evans, Kathryn, Bernstein, Daniel, Zeineh, Michael, Goubran, Maged, and Deisseroth, Karl

Subjects
Mental Health, Neurosciences, Cardiovascular, Heart Disease, 1.1 Normal biological development and functioning, Underpinning research, Mental health, Animals, Mice, Anxiety, Brain, Brain Mapping, Emotions, Heart, Behavior, Animal, Electrophysiology, Optogenetics, Insular Cortex, Heart Rate, Channelrhodopsins, Tachycardia, Pacemaker, Artificial, General Science & Technology
Abstract

Emotional states influence bodily physiology, as exemplified in the top-down process by which anxiety causes faster beating of the heart1-3. However, whether an increased heart rate might itself induce anxiety or fear responses is unclear3-8. Physiological theories of emotion, proposed over a century ago, have considered that in general, there could be an important and even dominant flow of information from the body to the brain9. Here, to formally test this idea, we developed a noninvasive optogenetic pacemaker for precise, cell-type-specific control of cardiac rhythms of up to 900 beats per minute in freely moving mice, enabled by a wearable micro-LED harness and the systemic viral delivery of a potent pump-like channelrhodopsin. We found that optically evoked tachycardia potently enhanced anxiety-like behaviour, but crucially only in risky contexts, indicating that both central (brain) and peripheral (body) processes may be involved in the development of emotional states. To identify potential mechanisms, we used whole-brain activity screening and electrophysiology to find brain regions that were activated by imposed cardiac rhythms. We identified the posterior insular cortex as a potential mediator of bottom-up cardiac interoceptive processing, and found that optogenetic inhibition of this brain region attenuated the anxiety-like behaviour that was induced by optical cardiac pacing. Together, these findings reveal that cells of both the body and the brain must be considered together to understand the origins of emotional or affective states. More broadly, our results define a generalizable approach for noninvasive, temporally precise functional investigations of joint organism-wide interactions among targeted cells during behaviour.

Published
2023

5. Age of Enchantment: Dusky hues and classic European patterns turned this Kentucky home into a fairy-tale cottage

Author

O'Shea-Evans, Kathryn

Subjects
Louisville, Kentucky -- Buildings and facilities, Interior design -- Methods, Cottages -- Decoration and finishing, Architecture and design industries, Home and garden, Home furnishings industry
Abstract

IN 1876 BRITISH textile wizard William Morris released Pimpernel, a coiling floral pattern. It was a good year for wallpaper in general, but he loved this particular pattern so much [...]

Published
2024

8. Refining epigenetic prediction of chronological and biological age

Author

Bernabeu, Elena, McCartney, Daniel L., Gadd, Danni A., Hillary, Robert F., Lu, Ake T., Murphy, Lee, Wrobel, Nicola, Campbell, Archie, Harris, Sarah E., Liewald, David, Hayward, Caroline, Sudlow, Cathie, Cox, Simon R., Evans, Kathryn L., Horvath, Steve, McIntosh, Andrew M., Robinson, Matthew R., Vallejos, Catalina A., and Marioni, Riccardo E.

Published
2023
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10. Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts

Author

Hillary, Robert F., Ng, Hong Kiat, McCartney, Daniel L., Elliott, Hannah R., Walker, Rosie M., Campbell, Archie, Huang, Felicia, Direk, Kenan, Welsh, Paul, Sattar, Naveed, Corley, Janie, Hayward, Caroline, McIntosh, Andrew M., Sudlow, Cathie, Evans, Kathryn L., Cox, Simon R., Chambers, John C., Loh, Marie, Relton, Caroline L., Marioni, Riccardo E., Yousefi, Paul D., and Suderman, Matthew

Published
2024
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12. Comprehensive evaluation of smoking exposures and their interactions on DNA methylation

Author

Heijmans, Bastiaan, ’t Hoen, Peter, van Meurs, Joyce, Jansen, Rick, Franke, Lude, Boomsma, Dorret, Pool, René, van Dongen, Jenny, Hottenga, Jouke, van Greevenbroek, Marleen, Stehouwer, Coen, van der Kallen, Carla, Schalkwijk, Casper, Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje, Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, Van Heemst, Diana, Veldink, Jan, van den Berg, Leonard, van Duijn, Cornelia, Hofman, Bert, Isaacs, Aaron, Uitterlinden, André, Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka, Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha, van ‘t Hof, Peter, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, Bonder, Marc, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon, Swertz, Morris, van Zwet, Erik, Hoang, Thanh T., Lee, Yunsung, McCartney, Daniel L., Kersten, Elin T.G., Page, Christian M., Hulls, Paige M., Lee, Mikyeong, Walker, Rosie M., Breeze, Charles E., Bennett, Brian D., Burkholder, Adam B., Ward, James, Brantsæter, Anne Lise, Caspersen, Ida H., Motsinger-Reif, Alison A., Richards, Marie, White, Julie D., Zhao, Shanshan, Richmond, Rebecca C., Magnus, Maria C., Koppelman, Gerard H., Evans, Kathryn L., Marioni, Riccardo E., Håberg, Siri E., and London, Stephanie J.

Published
2024
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13. Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci

Author

Breeze, Charles E, Batorsky, Anna, Lee, Mi Kyeong, Szeto, Mindy D, Xu, Xiaoguang, McCartney, Daniel L, Jiang, Rong, Patki, Amit, Kramer, Holly J, Eales, James M, Raffield, Laura, Lange, Leslie, Lange, Ethan, Durda, Peter, Liu, Yongmei, Tracy, Russ P, Van Den Berg, David, Evans, Kathryn L, Kraus, William E, Shah, Svati, Tiwari, Hermant K, Hou, Lifang, Whitsel, Eric A, Jiang, Xiao, Charchar, Fadi J, Baccarelli, Andrea A, Rich, Stephen S, Morris, Andrew P, Irvin, Marguerite R, Arnett, Donna K, Hauser, Elizabeth R, Rotter, Jerome I, Correa, Adolfo, Hayward, Caroline, Horvath, Steve, Marioni, Riccardo E, Tomaszewski, Maciej, Beck, Stephan, Berndt, Sonja I, London, Stephanie J, Mychaleckyj, Josyf C, and Franceschini, Nora

Subjects
Biological Sciences, Genetics, Kidney Disease, Human Genome, Renal and urogenital, CpG Islands, DNA Methylation, Epigenesis, Genetic, Epigenomics, Gene Expression Regulation, Genetic Variation, Genetics, Population, Genome-Wide Association Study, Glomerular Filtration Rate, Humans, Kidney, Kidney Function Tests, Phenotype, Quantitative Trait Loci, Quantitative Trait, Heritable, Racial Groups, Epigenetic, Kidney function, Gene regulation, Kidney development, DNA methylation, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed MESA Multi-Omics Working Group, Clinical Sciences
Abstract

BackgroundDNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly understood. We aimed to identify trans-ethnic and ethnic-specific differentially methylated positions (DMPs) associated with eGFR using an agnostic, genome-wide approach.MethodsThe study included up to 5428 participants from multi-ethnic studies for discovery and 8109 participants for replication. We tested the associations between whole blood DNAm and eGFR using beta values from Illumina 450K or EPIC arrays. Ethnicity-stratified analyses were performed using linear mixed models adjusting for age, sex, smoking, and study-specific and technical variables. Summary results were meta-analyzed within and across ethnicities. Findings were assessed using integrative epigenomics methods and pathway analyses.ResultsWe identified 93 DMPs associated with eGFR at an FDR of 0.05 and replicated 13 and 1 DMPs across independent samples in trans-ethnic and African American meta-analyses, respectively. The study also validated 6 previously published DMPs. Identified DMPs showed significant overlap enrichment with DNase I hypersensitive sites in kidney tissue, sites associated with the expression of proximal genes, and transcription factor motifs and pathways associated with kidney tissue and kidney development.ConclusionsWe uncovered trans-ethnic and ethnic-specific DMPs associated with eGFR, including DMPs enriched in regulatory elements in kidney tissue and pathways related to kidney development. These findings shed light on epigenetic mechanisms associated with kidney function, bridging the gap between population-specific eGFR-associated DNAm and tissue-specific regulatory context.

Published
2021

14. Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes

Author

Cheng, Yipeng, Gadd, Danni A., Gieger, Christian, Monterrubio-Gómez, Karla, Zhang, Yufei, Berta, Imrich, Stam, Michael J., Szlachetka, Natalia, Lobzaev, Evgenii, Wrobel, Nicola, Murphy, Lee, Campbell, Archie, Nangle, Cliff, Walker, Rosie M., Fawns-Ritchie, Chloe, Peters, Annette, Rathmann, Wolfgang, Porteous, David J., Evans, Kathryn L., McIntosh, Andrew M., Cannings, Timothy I., Waldenberger, Melanie, Ganna, Andrea, McCartney, Daniel L., Vallejos, Catalina A., and Marioni, Riccardo E.

Published
2023
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15. Designers share 7 go-to paint colors for your front door

Author

O'Shea-Evans, Kathryn

Subjects
Color -- Varieties, Doors -- Decoration and finishing, Paint -- Varieties, Architecture, Domestic -- Methods, General interest, News, opinion and commentary
Abstract

Byline: Kathryn O'Shea-Evans A front door color can make or break your home's curb appeal. The perfect shade and finish are more than just eye candy; they set the tone [...]

Published
2024

16. Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks

Author

Gospodinova, Katerina O., Olsen, Ditte, Kaas, Mathias, Anderson, Susan M., Phillips, Jonathan, Walker, Rosie M., Bermingham, Mairead L., Payne, Abigail L., Giannopoulos, Panagiotis, Pandya, Divya, Spires-Jones, Tara L., Abbott, Catherine M., Porteous, David J., Glerup, Simon, and Evans, Kathryn L.

Published
2023
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17. Zero-shot topic generation

Author

Vasilyev, Oleg, Evans, Kathryn, Venancio-Marques, Anna, and Bohannon, John

Subjects
Computer Science - Computation and Language
Abstract

We present an approach to generating topics using a model trained only for document title generation, with zero examples of topics given during training. We leverage features that capture the relevance of a candidate span in a document for the generation of a title for that document. The output is a weighted collection of the phrases that are most relevant for describing the document and distinguishing it within a corpus, without requiring access to the rest of the corpus. We conducted a double-blind trial in which human annotators scored the quality of our machine-generated topics along with original human-written topics associated with news articles from The Guardian and The Huffington Post. The results show that our zero-shot model generates topic labels for news documents that are on average equal to or higher quality than those written by humans, as judged by humans., Comment: 12 pages, 9 figures, 3 tables

Published
2020

20. The Big Chill: Bathed in cool blue, this Kansas City home gets warmth from rosy accents

Author

O'Shea-Evans, Kathryn

Subjects
Interior design -- Methods, Mansions -- Design and construction, Architecture and design industries, Home and garden, Home furnishings industry
Abstract

Red and blue. The timeless color pairing has long bewitched designer Mark D. Sikes--and countless others before him. One particularly storied item in this colorway sparked a vision for his [...]

Published
2023

21. RAISING the BARN: A Dutch barn from the 1800s enjoys new life as a rustic retreat that welcomes the whole family to come kick up their boots--the muddier, the better

Author

O'Shea-Evans, Kathryn

Subjects
Farmhouses -- Design and construction, Barns -- Remodeling and renovation -- History, Food/cooking/nutrition, Home and garden
Abstract

There's just something about a barn that tugs at a person's heartstrings. 'They're timeless and part of our country's history,' says Chris Clay, architect for Bozeman, Montana-based Miller Roodell Architects [...]

Published
2023

22. Blood- and brain-based genome-wide association studies of smoking

Author

Chybowska, Aleksandra D., primary, Bernabeu, Elena, additional, Yousefi, Paul, additional, Suderman, Matthew, additional, Hillary, Robert F., additional, MacGillivray, Louise, additional, Murphy, Lee, additional, Harris, Sarah E., additional, Corley, Janie, additional, Campbell, Archie, additional, Spires-Jones, Tara L., additional, McCartney, Daniel L., additional, Cox, Simon R., additional, Price, Jackie F., additional, Evans, Kathryn L., additional, and Marioni, Riccardo E., additional

Published
2024
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25. Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging

Author

Jung, Jeesun, McCartney, Daniel L., Wagner, Josephin, Rosoff, Daniel B., Schwandt, Melanie, Sun, Hui, Wiers, Corinde E., de Carvalho, Luana Martins, Volkow, Nora D., Walker, Rosie M., Campbell, Archie, Porteous, David J., McIntosh, Andrew M., Marioni, Riccardo E., Horvath, Steve, Evans, Kathryn L., and Lohoff, Falk W.

Published
2022
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27. A Little Cabin: Little did these Homeowners know what was hiding behind their walls: a 60-year-old log cabin

Author

O'Shea-Evans, Kathryn

Subjects
Interior design -- Methods, Designers -- Beliefs, opinions and attitudes -- Homes and haunts, Architecture, Domestic -- Methods, Architects -- Beliefs, opinions and attitudes -- Homes and haunts, Architecture and design industries, Home and garden, Home furnishings industry
Abstract

Something was definitely beneath the drywall. Nestled in the shadow of the Teton mountains, Jackson Hole, Wyoming, is a fairy tale of a town. But when designer Emily Janak and [...]

Published
2022

28. Designers say âunexpected redâ really works. Hereâs how to use it

Author

Evans, Kathryn O'Shea

Subjects
General interest, News, opinion and commentary
Abstract

Byline: Kathryn O'Shea Evans For proof that everything old is new again, look no further than one of the latest viral design fads: placing a red item in every room [...]

Published
2024

29. Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder

Author

Jung, Jeesun, McCartney, Daniel L., Wagner, Josephin, Yoo, Joyce, Bell, Andrew S., Mavromatis, Lucas A., Rosoff, Daniel B., Hodgkinson, Colin A., Sun, Hui, Schwandt, Melanie, Diazgranados, Nancy, Smith, Alicia K., Michopoulos, Vasiliki, Powers, Abigail, Stevens, Jennifer, Bradley, Bekh, Fani, Negar, Walker, Rosie M., Campbell, Archie, Porteous, David J., McIntosh, Andrew M., Horvath, Steve, Marioni, Riccardo E., Evans, Kathryn L., Goldman, David, and Lohoff, Falk W.

Published
2023
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31. Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design

Author

Rokita, Jo Lynne, Rathi, Komal S, Cardenas, Maria F, Upton, Kristen A, Jayaseelan, Joy, Cross, Katherine L, Pfeil, Jacob, Egolf, Laura E, Way, Gregory P, Farrel, Alvin, Kendsersky, Nathan M, Patel, Khushbu, Gaonkar, Krutika S, Modi, Apexa, Berko, Esther R, Lopez, Gonzalo, Vaksman, Zalman, Mayoh, Chelsea, Nance, Jonas, McCoy, Kristyn, Haber, Michelle, Evans, Kathryn, McCalmont, Hannah, Bendak, Katerina, Böhm, Julia W, Marshall, Glenn M, Tyrrell, Vanessa, Kalletla, Karthik, Braun, Frank K, Qi, Lin, Du, Yunchen, Zhang, Huiyuan, Lindsay, Holly B, Zhao, Sibo, Shu, Jack, Baxter, Patricia, Morton, Christopher, Kurmashev, Dias, Zheng, Siyuan, Chen, Yidong, Bowen, Jay, Bryan, Anthony C, Leraas, Kristen M, Coppens, Sara E, Doddapaneni, HarshaVardhan, Momin, Zeineen, Zhang, Wendong, Sacks, Gregory I, Hart, Lori S, Krytska, Kateryna, Mosse, Yael P, Gatto, Gregory J, Sanchez, Yolanda, Greene, Casey S, Diskin, Sharon J, Vaske, Olena Morozova, Haussler, David, Gastier-Foster, Julie M, Kolb, E Anders, Gorlick, Richard, Li, Xiao-Nan, Reynolds, C Patrick, Kurmasheva, Raushan T, Houghton, Peter J, Smith, Malcolm A, Lock, Richard B, Raman, Pichai, Wheeler, David A, and Maris, John M

Subjects
Biological Sciences, Pediatric, Rare Diseases, Genetics, Human Genome, Pediatric Cancer, Pediatric Research Initiative, Clinical Research, Orphan Drug, Biotechnology, Cancer, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Animals, Cell Line, Tumor, Central Nervous System Neoplasms, Child, Clinical Trials as Topic, Disease Models, Animal, Genomics, Humans, Mice, Mutation, Neuroblastoma, Neurofibromin 1, Osteosarcoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Tumor Suppressor Protein p53, Exome Sequencing, Wilms Tumor, Xenograft Model Antitumor Assays, classifier, copy number profiling, patient-derived xenograft, pediatric cancer, preclinical testing, relapse, transcriptome sequencing, whole-exome sequencing, Pediatric cancer, whole exome sequencing, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited therapeutic options. To systematically prioritize and rationally test novel agents in preclinical murine models, researchers within the Pediatric Preclinical Testing Consortium are continuously developing patient-derived xenografts (PDXs)-many of which are refractory to current standard-of-care treatments-from high-risk childhood cancers. Here, we genomically characterize 261 PDX models from 37 unique pediatric cancers; demonstrate faithful recapitulation of histologies and subtypes; and refine our understanding of relapsed disease. In addition, we use expression signatures to classify tumors for TP53 and NF1 pathway inactivation. We anticipate that these data will serve as a resource for pediatric oncology drug development and will guide rational clinical trial design for children with cancer.

Published
2019

32. The Hunt for BURRIED TREASURE: It took three shopping trips to the European countryside to truly complete this wine country getaway

Author

O'Shea-Evans, Kathryn

Subjects
Interior design -- Methods, Dwellings -- Remodeling and renovation -- Decoration and finishing, Housing -- Remodeling and renovation -- Decoration and finishing, Architecture and design industries, Home and garden, Home furnishings industry
Abstract

LIKE A THEATER SET, THE 20-foot ceilings of this Healdsburg, California, home put every furnishing, accent, and architectural flourish in the spotlight. Doors and windows stretch 10 feet tall (the [...]

Published
2022

33. Morphological profiling in human neural progenitor cells classifies hits in a pilot drug screen for Alzheimer’s disease

Author

McDiarmid, Amina H, primary, Gospodinova, Katerina O, additional, Elliott, Richard J R, additional, Dawson, John C, additional, Hughes, Rebecca E, additional, El-Daher, Marie-Therese, additional, Anderson, Susan M, additional, Glen, Sophie C, additional, Glerup, Simon, additional, Carragher, Neil O, additional, and Evans, Kathryn L, additional

Published
2024
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35. Blood-based DNA methylation study of alcohol consumption

Author

Bernabeu, Elena, primary, Chybowska, Aleksandra, additional, Kresovich, Jacob K, additional, Suderman, Matthew, additional, McCartney, Daniel L., additional, Hillary, Robert F, additional, Corley, Janie, additional, Valdes Hernandez, Maria Del Carmen, additional, Munoz Maniega, Susana, additional, Bastin, Mark E, additional, Wardlaw, Joanna M, additional, Xu, Zongli, additional, Sandler, Dale P., additional, Campbell, Archie, additional, Harris, Sarah E, additional, McIntosh, Andrew M, additional, Taylor, Jack, additional, Yousefi, Paul Darius, additional, Cox, Simon R, additional, Evans, Kathryn L, additional, Robinson, Matthew Richard, additional, Vallejos, Catalina A, additional, and Marioni, Riccardo, additional

Published
2024
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36. Comprehensive evaluation of smoking exposures and their interactions on DNA methylation

Author

Hoang, Thanh T., primary, Lee, Yunsung, additional, McCartney, Daniel L., additional, Kersten, Elin T.G., additional, Page, Christian M., additional, Hulls, Paige M., additional, Lee, Mikyeong, additional, Walker, Rosie M., additional, Breeze, Charles E., additional, Bennett, Brian D., additional, Burkholder, Adam B., additional, Ward, James, additional, Brantsæter, Anne Lise, additional, Caspersen, Ida H., additional, Motsinger-Reif, Alison A., additional, Richards, Marie, additional, White, Julie D., additional, Zhao, Shanshan, additional, Richmond, Rebecca C., additional, Magnus, Maria C., additional, Koppelman, Gerard H., additional, Evans, Kathryn L., additional, Marioni, Riccardo E., additional, Håberg, Siri E., additional, London, Stephanie J., additional, Heijmans, Bastiaan, additional, ’t Hoen, Peter, additional, van Meurs, Joyce, additional, Jansen, Rick, additional, Franke, Lude, additional, Boomsma, Dorret, additional, Pool, René, additional, van Dongen, Jenny, additional, Hottenga, Jouke, additional, van Greevenbroek, Marleen, additional, Stehouwer, Coen, additional, van der Kallen, Carla, additional, Schalkwijk, Casper, additional, Wijmenga, Cisca, additional, Zhernakova, Sasha, additional, Tigchelaar, Ettje, additional, Slagboom, P. Eline, additional, Beekman, Marian, additional, Deelen, Joris, additional, Van Heemst, Diana, additional, Veldink, Jan, additional, van den Berg, Leonard, additional, van Duijn, Cornelia, additional, Hofman, Bert, additional, Isaacs, Aaron, additional, Uitterlinden, André, additional, Jhamai, P. Mila, additional, Verbiest, Michael, additional, Suchiman, H. Eka, additional, Verkerk, Marijn, additional, van der Breggen, Ruud, additional, van Rooij, Jeroen, additional, Lakenberg, Nico, additional, Mei, Hailiang, additional, van Iterson, Maarten, additional, van Galen, Michiel, additional, Bot, Jan, additional, Zhernakova, Dasha, additional, van ‘t Hof, Peter, additional, Deelen, Patrick, additional, Nooren, Irene, additional, Moed, Matthijs, additional, Vermaat, Martijn, additional, Luijk, René, additional, Bonder, Marc, additional, van Dijk, Freerk, additional, Arindrarto, Wibowo, additional, Kielbasa, Szymon, additional, Swertz, Morris, additional, and van Zwet, Erik, additional

Published
2024
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38. Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

Author

Gadd, Danni A., Hillary, Robert F., McCartney, Daniel L., Shi, Liu, Stolicyn, Aleks, Robertson, Neil A., Walker, Rosie M., McGeachan, Robert I., Campbell, Archie, Xueyi, Shen, Barbu, Miruna C., Green, Claire, Morris, Stewart W., Harris, Mathew A., Backhouse, Ellen V., Wardlaw, Joanna M., Steele, J. Douglas, Oyarzún, Diego A., Muniz-Terrera, Graciela, Ritchie, Craig, Nevado-Holgado, Alejo, Chandra, Tamir, Hayward, Caroline, Evans, Kathryn L., Porteous, David J., Cox, Simon R., Whalley, Heather C., McIntosh, Andrew M., and Marioni, Riccardo E.

Published
2022
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41. Blood-based epigenome-wide analyses of cognitive abilities

Author

McCartney, Daniel L., Hillary, Robert F., Conole, Eleanor L. S., Banos, Daniel Trejo, Gadd, Danni A., Walker, Rosie M., Nangle, Cliff, Flaig, Robin, Campbell, Archie, Murray, Alison D., Maniega, Susana Muñoz, Valdés-Hernández, María del C., Harris, Mathew A., Bastin, Mark E., Wardlaw, Joanna M., Harris, Sarah E., Porteous, David J., Tucker-Drob, Elliot M., McIntosh, Andrew M., Evans, Kathryn L., Deary, Ian J., Cox, Simon R., Robinson, Matthew R., and Marioni, Riccardo E.

Published
2022
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42. Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/glutamate transporter SLC7A11 as a top target

Author

Lohoff, Falk W., Clarke, Toni-Kim, Kaminsky, Zachary A., Walker, Rosie M., Bermingham, Mairead L., Jung, Jeesun, Morris, Stewart W., Rosoff, Daniel, Campbell, Archie, Barbu, Miruna, Charlet, Katrin, Adams, Mark, Lee, Jisoo, Howard, David M., O’Connell, Emma M., Whalley, Heather, Porteous, David J., McIntosh, Andrew M., and Evans, Kathryn L.

Published
2022
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43. Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system

Author

Barbu, Miruna C., Huider, Floris, Campbell, Archie, Amador, Carmen, Adams, Mark J., Lynall, Mary-Ellen, Howard, David M., Walker, Rosie M., Morris, Stewart W., Van Dongen, Jenny, Porteous, David J., Evans, Kathryn L., Bullmore, Edward, Willemsen, Gonneke, Boomsma, Dorret I., Whalley, Heather C., and McIntosh, Andrew M.

Published
2022
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45. Shared Genomic Regions Underlie Natural Variation in Diverse Toxin Responses

Author

Evans, Kathryn S, Brady, Shannon C, Bloom, Joshua S, Tanny, Robyn E, Cook, Daniel E, Giuliani, Sarah E, Hippleheuser, Stephen W, Zamanian, Mostafa, and Andersen, Erik C

Subjects
Biological Sciences, Genetics, Biotechnology, Human Genome, Generic health relevance, Alleles, Animals, Caenorhabditis elegans, Chromosome Mapping, Epistasis, Genetic, Genomics, Metals, Heavy, Neurotoxins, Pesticides, Quantitative Trait Loci, C. elegans, QTL, genetic interactions, toxin, pleiotropy, Developmental Biology, Biochemistry and cell biology
Abstract

Phenotypic complexity is caused by the contributions of environmental factors and multiple genetic loci, interacting or acting independently. Studies of yeast and Arabidopsis often find that the majority of natural variation across phenotypes is attributable to independent additive quantitative trait loci (QTL). Detected loci in these organisms explain most of the estimated heritable variation. By contrast, many heritable components underlying phenotypic variation in metazoan models remain undetected. Before the relative impacts of additive and interactive variance components on metazoan phenotypic variation can be dissected, high replication and precise phenotypic measurements are required to obtain sufficient statistical power to detect loci contributing to this missing heritability. Here, we used a panel of 296 recombinant inbred advanced intercross lines of Caenorhabditis elegans and a high-throughput fitness assay to detect loci underlying responses to 16 different toxins, including heavy metals, chemotherapeutic drugs, pesticides, and neuropharmaceuticals. Using linkage mapping, we identified 82 QTL that underlie variation in responses to these toxins, and predicted the relative contributions of additive loci and genetic interactions across various growth parameters. Additionally, we identified three genomic regions that impact responses to multiple classes of toxins. These QTL hotspots could represent common factors impacting toxin responses. We went further to generate near-isogenic lines and chromosome substitution strains, and then experimentally validated these QTL hotspots, implicating additive and interactive loci that underlie toxin-response variation.

Published
2018

46. DOES IT GET MORE MAINE THAN THIS? Nested between a tidal pool and blueberry bushes, this shingled cottage exudes a been-around-forever, bring-on-the-sandy-feet spirit

Author

O'Shea-Evans, Kathryn

Subjects
Tide pool ecology, Food/cooking/nutrition, Home and garden
Abstract

RECENTLY, the internet has become slightly obsessed with a relaxed-meets-refined design aesthetic known as 'Coastal Grandmother,' inspired in part by Hollywood director Nancy Meyers (Something's Gotta Give, It's Complicated). If [...]

Published
2022

47. TINY CASTLE BY THE COAST

Author

O'Shea-Evans, Kathryn

Subjects
Ice cream, ices, etc., Food/cooking/nutrition, Home and garden
Abstract

When you set up camp in a former ice-cream hut, you're destined to discover the sweetest side of summer. (Sprinkles optional.) Remember that cozy Nordic concept of hygge? It applies [...]

Published
2022

48. 7 ways to make your guest room feel like a luxury hotel

Author

O'Shea-Evans, Kathryn

Subjects
General interest, News, opinion and commentary
Abstract

Byline: Kathryn O'Shea-Evans When I was growing up, my dad excused our stays at dreary roadside motels with one simple comment: 'When you're asleep, it's exactly the same as the [...]

Published
2023

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