30 results on '"Evans, Liam"'
Search Results
2. Tissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids
- Author
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Lean, Fabian Z.X., Cox, Ruth, Madslien, Knut, Spiro, Simon, Nymo, Ingebjørg Helena, Bröjer, Caroline, Neimanis, Aleksija, Lawson, Becki, Holmes, Paul, Man, Catherine, Folkow, Lars P., Gough, Julie, Ackroyd, Stuart, Evans, Liam, Wrigglesworth, Ethan, Grimholt, Unni, McElhinney, Lorraine, Brookes, Sharon M., Delahay, Richard J., and Núñez, Alejandro
- Published
- 2023
- Full Text
- View/download PDF
3. Synthesis and characterization of human metabolites of the echinocandid drug rezafungin by microbial biotransformation
- Author
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Shanu-Wilson, Julia, primary, Manohar, Ravi, additional, Gomez, Adriana, additional, Phipps, Richard, additional, Steele, Jonathan, additional, Wrigley, Stephen, additional, Evans, Liam, additional, and Scheffler, Frank, additional
- Published
- 2024
- Full Text
- View/download PDF
4. Contributors
- Author
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Al Qaraghuli, Farah, primary, Alluri, Ravindra Varma, additional, Argon, Sophie M.A., additional, Bajaj, Piyush, additional, Bapiro, Tashinga E., additional, Basit, Abdul, additional, Brink, Andreas, additional, Cai, Tingting, additional, Castro-Perez, Jose, additional, Chang, Jae H., additional, Chen, Eugene Chia-Te, additional, Croft, Marie, additional, Evans, Liam, additional, Evers, Raymond, additional, Foti, Robert S., additional, Fretland, Adrian J., additional, Gemski, Christopher, additional, Ghosal, Anima, additional, Hao, Jia, additional, Haridas, Satyajeet, additional, Hauri, Simon, additional, Isoherranen, Nina, additional, Jian, Wenying, additional, Johnson, Kevin, additional, Jones, Barry, additional, Jones, Robert S., additional, Joseph, Jan Felix, additional, Khojasteh, S. Cyrus, additional, Lai, Yurong, additional, Le, Hoa, additional, Liang, Xiaomin, additional, Liu, Liming, additional, Lopes, Filipe, additional, Ly, Justin Q., additional, Ma, Shuguang, additional, Markandu, Roshini, additional, Masereeuw, Rosalinde, additional, McDuffie, J. Eric, additional, Mitra, Kaushik, additional, Montgomery, Diana, additional, Orton, Alexandra L., additional, Owens, Katie H., additional, Pähler, Axel, additional, Parr, Maria Kristina, additional, Patel, Shefali, additional, Petrie, Ichiko D., additional, Phipps, Richard, additional, Prakash, Chandra, additional, Prasad, Bhagwat, additional, Ragueneau-Majlessi, Isabelle, additional, Reddy, Venkatesh Pilla, additional, Riddle, Ellen, additional, Ruan, Qian, additional, Schadt, Simone, additional, Shah, Dhaval K., additional, Shanu-Wilson, Julia, additional, Staiger, Kelly MacLennan, additional, Steele, Jonathan, additional, Varma, Manthena V.S., additional, Wagoner, Matthew P., additional, Weng, Naidong, additional, Wrigley, Stephen, additional, Wu, Caisheng, additional, Young, Graeme C., additional, Yu, Jingjing, additional, Yu, Lushan, additional, Zeng, Su, additional, Zhang, Haeyoung, additional, Zhang, Wanying, additional, Zhu, Andy Z.X., additional, and Zhu, Mingshe, additional
- Published
- 2020
- Full Text
- View/download PDF
5. Methods for metabolite generation and characterization by NMR
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Evans, Liam, primary, Phipps, Richard, additional, Shanu-Wilson, Julia, additional, Steele, Jonathan, additional, and Wrigley, Stephen, additional
- Published
- 2020
- Full Text
- View/download PDF
6. Experience-based decision support methodology for manufacturing technology selection : a fuzzy-decision-tree mining approach
- Author
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Evans, Liam
- Subjects
658.5 ,T Technology (General) - Abstract
Manufacturing companies must invest in new technologies and processes to succeed in a rapidly changing global environment. Managers have the difficulty of justifying capital investment in adopting new, state-of-the-art technology. Technology investment accounts for a large part of capital spending and is a key form of improving competitive advantage. Typical approaches focus on the expected return of investment and financial reward gained from the implementation of such equipment. With an increasingly dynamic market environment and global economic model, forecasting of financial payback can be argued to become increasingly less accurate. Subsequently, less quantifiable factors are becoming increasingly important. For example, the alignment of a technology with an organisations objective to fulfil future potential and gain competitive advantage is becoming as crucial as economic evaluation. In addition, the impact on human operators and skill level required must be considered. This research was motivated by the lack of decision methodologies that understand why a technology is more successful within an environment rather than re-examining the underlying performance attributes of a technology. The aim is to create a common approach where both experts and non-experts can use historical decision information to support the evaluation and selection of an optimal manufacturing technology. This form of approach is based on the logic in which a decision maker would irrationally recall previous decisions to identify relationships with new problem cases. The work investigates data mining and machine learning techniques to discover the underlying influences to improve technology selection under a set of dynamic factors. The approach initially discovers the practices to which an expert would conduct the selection of a manufacturing technology within industry. A defined understanding of the problem and techniques was subsequently concluded. This led to an understanding of the structure by which historical decision information is recalled by an expert to support new selection problems. The key attributes in the representation of a case were apparent and a form of characterising tangible and intangible variables was justified. This led to the development of a novel, experience-based manufacturing technology selection framework using fuzzy-decision-trees. The methodology is an iterative approach of learning from previously implemented technology cases. Rules and underlying knowledge of the relationships in past cases predicts the outcome of new decision problems. The link of information from a multitude of historical cases may identify those technologies with technical characteristics that perform optimally for projects with unique requirements. This also indicates the likeliness of technologies performing successfully based on the project requirements. Historical decision cases are represented through original project objectives, technical performance attributes of the chosen technology and judged project performance. The framework was shown to provide a comprehensive foundation for decision support that reduces the uncertainty and subjective influence within the selection process. The model was developed with industrial guidance to represent the actions of a manufacturing expert. The performance of the tool was measured by industrial experts. The approach was found to represent well the decision logic of a human expert based on their developed experience through cases. The application to an industrial decision case study demonstrated encouraging results and use by decision makers feasible. The model reduces the subjectivity in the process by using case information that is formed from multiple experts of a prior decision case. The model is applied in a shorter time period than existing practices and the ranking of potential solutions is well aligned to the understanding of a decision maker. To summarise, this research highlights the importance of focusing on less quantifiable factors and the performance of a technology to a specific problem/environment. The arrangement of case information thus represents the experience an expert would acquire and recall as part of the decision process.
- Published
- 2013
7. Optimized Fuzzy Decision Tree Data Mining for Engineering Applications
- Author
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Evans, Liam, Lohse, Niels, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, and Perner, Petra, editor
- Published
- 2011
- Full Text
- View/download PDF
8. A fuzzy-decision-tree approach for manufacturing technology selection exploiting experience-based information
- Author
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Evans, Liam, Lohse, Niels, and Summers, Mark
- Published
- 2013
- Full Text
- View/download PDF
9. Chapter 4 - Methods for metabolite generation and characterization by NMR
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Evans, Liam, Phipps, Richard, Shanu-Wilson, Julia, Steele, Jonathan, and Wrigley, Stephen
- Published
- 2020
- Full Text
- View/download PDF
10. Optimized Fuzzy Decision Tree Data Mining for Engineering Applications
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Evans, Liam, primary and Lohse, Niels, additional
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- 2011
- Full Text
- View/download PDF
11. An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum
- Author
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Evans, Liam, Hedger, John N., Brayford, David, Stavri, Michael, Smith, Eileen, O’Donnell, Gemma, Gray, Alexander I., Griffith, Gareth W., and Gibbons, Simon
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- 2006
- Full Text
- View/download PDF
12. Biotransformation: Impact and Application of Metabolism in Drug Discovery
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Shanu-Wilson, Julia, primary, Evans, Liam, additional, Wrigley, Stephen, additional, Steele, Jonathan, additional, Atherton, James, additional, and Boer, Jason, additional
- Published
- 2020
- Full Text
- View/download PDF
13. P25 - Accessing mammalian drug metabolites using PolyCYPs® enzymes
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Shanu-Wilson, Julia, primary, Hodds, William, additional, Lai, Sandie, additional, Phipps, Richard, additional, de Riso, Antonio, additional, Poon, Vincent, additional, Nytko, Kinga, additional, Khan, Aksana, additional, Evans, Liam, additional, Scheffler, Frank, additional, and Steele, Jonathan, additional
- Published
- 2020
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- View/download PDF
14. P10 - Use of microbial biotransformation to produce scalable quantities of a glucuronidated metabolite of the clinical-stage soluble guanylate cyclase inhibitor praliciguat
- Author
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Shanu-Wilson, Julia, primary, Steele, Jonathan, additional, Phipps, Richard, additional, Manohar, Ravi, additional, Karunakaran, Deepa, additional, Borowik, Alicja, additional, Scheffler, Frank, additional, Evans, Liam, additional, Carvalho, Andrew, additional, and Banijamali, Ali, additional
- Published
- 2020
- Full Text
- View/download PDF
15. A prospective evaluation of rivaroxaban on haemostatic parameters in apparently healthy dogs
- Author
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Evans, Liam A., primary, Tansey, Colleen, additional, Wiebe, Melissa, additional, Sloan, Caroline Q., additional, Patlogar, Jeffrey E., additional, Northcutt, Sarah, additional, Murphy, Lisa A., additional, and Nakamura, Reid K., additional
- Published
- 2019
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- View/download PDF
16. Microbial biotransformation – an important tool for the study of drug metabolism
- Author
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Salter, Rhys, primary, Beshore, Douglas C., additional, Colletti, Steven L., additional, Evans, Liam, additional, Gong, Yong, additional, Helmy, Roy, additional, Liu, Yong, additional, Maciolek, Cheri M., additional, Martin, Gary, additional, Pajkovic, Natasa, additional, Phipps, Richard, additional, Small, James, additional, Steele, Jonathan, additional, de Vries, Ronald, additional, Williams, Headley, additional, and Martin, Iain J., additional
- Published
- 2018
- Full Text
- View/download PDF
17. Justification for the selection of manufacturing technologies: a fuzzy-decision-tree-based approach.
- Author
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Evans, Liam, Lohse, Niels, Tan, KimHua, Webb, Phil, and Summers, Mark
- Subjects
FUZZY decision making ,MANUFACTURING processes ,MATHEMATICAL models ,PRODUCTION engineering ,DECISION making ,PRODUCTION scheduling ,PRODUCTION management (Manufacturing) - Abstract
In this paper, a developed model for the justification of alternative manufacturing technologies is presented. The approach, based on fuzzy decision trees, provides a methodology capable of identifying patterns within a technology case repository to support the evaluation of manufacturing systems. Experts are highly influential individuals in the decision process; they provide support and guidance when selecting investments. The experience-oriented task is founded on previous cases or an experts’ experience, and therefore difficult to express in a rational form. The concept is based on a number of characteristics of the case-based reasoning, rule induction and expert system theory. Structured around the fuzzy-decision-tree data-mining technique, the framework provides the ability of using regulated case information to act as structured experience for assisting in the decision process. Fuzzy induction extracts formal rules from a set of experience data, and the expert system philosophy computes the experience base of human expertise for problem-solving. A test case indicates the stability of the classification algorithm and verifies the applicability within the domain. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
- Full Text
- View/download PDF
18. Corrigendum to “P25 - Accessing mammalian drug metabolites using PolyCYPs® enzymes” [Drug Metabol Pharmacokinet 35 (2020) S29]
- Author
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Lai, Sandie, Hodds, William, Poon, Vincent, Nytko, Kinga, Khan, Aksana, Hopkins, Emily, de Riso, Antonio, Phipps, Richard, Steele, Jonathan, Wrigley, Stephen, Evans, Liam, Scheffler, Frank, and Shanu-Wilson, Julia
- Published
- 2020
- Full Text
- View/download PDF
19. Emergency put my skills to the test
- Author
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Evans, Liam, primary
- Published
- 2017
- Full Text
- View/download PDF
20. Microbial biotransformation – an important tool for the study of drug metabolism.
- Author
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Salter, Rhys, Beshore, Douglas C., Colletti, Steven L., Evans, Liam, Gong, Yong, Helmy, Roy, Liu, Yong, Maciolek, Cheri M., Martin, Gary, Pajkovic, Natasa, Phipps, Richard, Small, James, Steele, Jonathan, de Vries, Ronald, Williams, Headley, and Martin, Iain J.
- Subjects
BIOTRANSFORMATION in microorganisms ,DRUG metabolism ,METABOLITES ,DRUG development ,CHEMICAL synthesis ,LIVER microsomes - Abstract
Metabolite identification is an integral part of both preclinical and clinical drug discovery and development. Synthesis of drug metabolites is often required to support definitive identification, preclinical safety studies and clinical trials. Here we describe the use of microbial biotransformation as a tool to produce drug metabolites, complementing traditional chemical synthesis and other biosynthetic methods such as hepatocytes, liver microsomes and recombinant human drug metabolizing enzymes. A workflow is discussed whereby microbial strains are initially screened for their ability to form the putative metabolites of interest, followed by a scale-up to afford quantities sufficient to perform definitive identification and further studies. Examples of the microbial synthesis of several difficult-to-synthesize hydroxylated metabolites and three difficult-to-synthesize glucuronidated metabolites are described, and the use of microbial biotransformation in drug discovery and development is discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
21. Structure elucidation of some highly unusual tricyclic cis-caryophyllane sesquiterpenes from Marasmiellus troyanus
- Author
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Evans, Liam, Hedger, John, O’Donnell, Gemma, Skelton, Brian W., White, Allan H., Williamson, R. Thomas, and Gibbons, Simon
- Published
- 2010
- Full Text
- View/download PDF
22. Intelligent experience based support tools for aerospace manufacturing technology selection.
- Author
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Evans, Liam, Lohse, Niels, and Summers, Mark
- Abstract
Data, information and knowledge have become an important commodity for manufacturing organizations in recent years. The effective capture and reuse of these ‘commodities’ can assist world-class organizations in maintaining competitive advantage. In the field of manufacturing technology selection, there is a vast amount of experienced information and knowledge sources supporting each phase of the process. These include documentation, technology catalogues, applied technologies and case studies, as well as a range of informal and formal information developed through discussions and meetings. The effective utilization and application of these information and knowledge commodities can assist organizations in next generation decision-making to ensure they select and invest wisely in optimized systems. This paper presents background literature of knowledge acquisition in manufacturing. The data, information and knowledge generated within the technology selection process are then studied. A conceptual framework to improve expertise transfer is presented for manufacturing technology decision support. The model identifies the link in a manufacturing organization to combine and improve the overall approach to manufacturing technology investment by collating relevant experience. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
- Full Text
- View/download PDF
23. Experience-based decision support methodology for manufacturing technology selection: a fuzzy-decision-tree mining approach
- Author
-
Evans, Liam
- Abstract
Manufacturing companies must invest in new technologies and processes to succeed in a rapidly changing global environment. Managers have the difficulty of justifying capital investment in adopting new, state-of-the-art technology. Technology investment accounts for a large part of capital spending and is a key form of improving competitive advantage. Typical approaches focus on the expected return of investment and financial reward gained from the implementation of such equipment. With an increasingly dynamic market environment and global economic model, forecasting of financial payback can be argued to become increasingly less accurate. Subsequently, less quantifiable factors are becoming increasingly important. For example, the alignment of a technology with an organisations objective to fulfil future potential and gain competitive advantage is becoming as crucial as economic evaluation. In addition, the impact on human operators and skill level required must be considered. This research was motivated by the lack of decision methodologies that understand why a technology is more successful within an environment rather than re-examining the underlying performance attributes of a technology. The aim is to create a common approach where both experts and non-experts can use historical decision information to support the evaluation and selection of an optimal manufacturing technology. This form of approach is based on the logic in which a decision maker would irrationally recall previous decisions to identify relationships with new problem cases. The work investigates data mining and machine learning techniques to discover the underlying influences to improve technology selection under a set of dynamic factors. The approach initially discovers the practices to which an expert would conduct the selection of a manufacturing technology within industry. A defined understanding of the problem and techniques was subsequently concluded. This led to an understanding of the structure by which historical decision information is recalled by an expert to support new selection problems. The key attributes in the representation of a case were apparent and a form of characterising tangible and intangible variables was justified. This led to the development of a novel, experience-based manufacturing technology selection framework using fuzzy-decision-trees. The methodology is an iterative approach of learning from previously implemented technology cases. Rules and underlying knowledge of the relationships in past cases predicts the outcome of new decision problems. The link of information from a multitude of historical cases may identify those technologies with technical characteristics that perform optimally for projects with unique requirements. This also indicates the likeliness of technologies performing successfully based on the project requirements. Historical decision cases are represented through original project objectives, technical performance attributes of the chosen technology and judged project performance. The framework was shown to provide a comprehensive foundation for decision support that reduces the uncertainty and subjective influence within the selection process. The model was developed with industrial guidance to represent the actions of a manufacturing expert. The performance of the tool was measured by industrial experts. The approach was found to represent well the decision logic of a human expert based on their developed experience through cases. The application to an industrial decision case study demonstrated encouraging results and use by decision makers feasible. The model reduces the subjectivity in the process by using case information that is formed from multiple experts of a prior decision case. The model is applied in a shorter time period than existing practices and the ranking of potential solutions is well aligned to the understanding of a decision maker. To summarise, this research highlights the importance of focusing on less quantifiable factors and the performance of a technology to a specific problem/environment. The arrangement of case information thus represents the experience an expert would acquire and recall as part of the decision process.
24. Experience-based decision support methodology for manufacturing technology selection: a fuzzy-decision-tree mining approach
- Author
-
Evans, Liam and Evans, Liam
- Abstract
Manufacturing companies must invest in new technologies and processes to succeed in a rapidly changing global environment. Managers have the difficulty of justifying capital investment in adopting new, state-of-the-art technology. Technology investment accounts for a large part of capital spending and is a key form of improving competitive advantage. Typical approaches focus on the expected return of investment and financial reward gained from the implementation of such equipment. With an increasingly dynamic market environment and global economic model, forecasting of financial payback can be argued to become increasingly less accurate. Subsequently, less quantifiable factors are becoming increasingly important. For example, the alignment of a technology with an organisations objective to fulfil future potential and gain competitive advantage is becoming as crucial as economic evaluation. In addition, the impact on human operators and skill level required must be considered. This research was motivated by the lack of decision methodologies that understand why a technology is more successful within an environment rather than re-examining the underlying performance attributes of a technology. The aim is to create a common approach where both experts and non-experts can use historical decision information to support the evaluation and selection of an optimal manufacturing technology. This form of approach is based on the logic in which a decision maker would irrationally recall previous decisions to identify relationships with new problem cases. The work investigates data mining and machine learning techniques to discover the underlying influences to improve technology selection under a set of dynamic factors. The approach initially discovers the practices to which an expert would conduct the selection of a manufacturing technology within industry. A defined understanding of the problem and techniques was subsequently concluded. This led to an understanding of the str
25. Experience-based decision support methodology for manufacturing technology selection: a fuzzy-decision-tree mining approach
- Author
-
Evans, Liam and Evans, Liam
- Abstract
Manufacturing companies must invest in new technologies and processes to succeed in a rapidly changing global environment. Managers have the difficulty of justifying capital investment in adopting new, state-of-the-art technology. Technology investment accounts for a large part of capital spending and is a key form of improving competitive advantage. Typical approaches focus on the expected return of investment and financial reward gained from the implementation of such equipment. With an increasingly dynamic market environment and global economic model, forecasting of financial payback can be argued to become increasingly less accurate. Subsequently, less quantifiable factors are becoming increasingly important. For example, the alignment of a technology with an organisations objective to fulfil future potential and gain competitive advantage is becoming as crucial as economic evaluation. In addition, the impact on human operators and skill level required must be considered. This research was motivated by the lack of decision methodologies that understand why a technology is more successful within an environment rather than re-examining the underlying performance attributes of a technology. The aim is to create a common approach where both experts and non-experts can use historical decision information to support the evaluation and selection of an optimal manufacturing technology. This form of approach is based on the logic in which a decision maker would irrationally recall previous decisions to identify relationships with new problem cases. The work investigates data mining and machine learning techniques to discover the underlying influences to improve technology selection under a set of dynamic factors. The approach initially discovers the practices to which an expert would conduct the selection of a manufacturing technology within industry. A defined understanding of the problem and techniques was subsequently concluded. This led to an understanding of the str
26. Experience-based decision support methodology for manufacturing technology selection: a fuzzy-decision-tree mining approach
- Author
-
Evans, Liam and Evans, Liam
- Abstract
Manufacturing companies must invest in new technologies and processes to succeed in a rapidly changing global environment. Managers have the difficulty of justifying capital investment in adopting new, state-of-the-art technology. Technology investment accounts for a large part of capital spending and is a key form of improving competitive advantage. Typical approaches focus on the expected return of investment and financial reward gained from the implementation of such equipment. With an increasingly dynamic market environment and global economic model, forecasting of financial payback can be argued to become increasingly less accurate. Subsequently, less quantifiable factors are becoming increasingly important. For example, the alignment of a technology with an organisations objective to fulfil future potential and gain competitive advantage is becoming as crucial as economic evaluation. In addition, the impact on human operators and skill level required must be considered. This research was motivated by the lack of decision methodologies that understand why a technology is more successful within an environment rather than re-examining the underlying performance attributes of a technology. The aim is to create a common approach where both experts and non-experts can use historical decision information to support the evaluation and selection of an optimal manufacturing technology. This form of approach is based on the logic in which a decision maker would irrationally recall previous decisions to identify relationships with new problem cases. The work investigates data mining and machine learning techniques to discover the underlying influences to improve technology selection under a set of dynamic factors. The approach initially discovers the practices to which an expert would conduct the selection of a manufacturing technology within industry. A defined understanding of the problem and techniques was subsequently concluded. This led to an understanding of the str
27. Experience-based decision support methodology for manufacturing technology selection: a fuzzy-decision-tree mining approach
- Author
-
Evans, Liam and Evans, Liam
- Abstract
Manufacturing companies must invest in new technologies and processes to succeed in a rapidly changing global environment. Managers have the difficulty of justifying capital investment in adopting new, state-of-the-art technology. Technology investment accounts for a large part of capital spending and is a key form of improving competitive advantage. Typical approaches focus on the expected return of investment and financial reward gained from the implementation of such equipment. With an increasingly dynamic market environment and global economic model, forecasting of financial payback can be argued to become increasingly less accurate. Subsequently, less quantifiable factors are becoming increasingly important. For example, the alignment of a technology with an organisations objective to fulfil future potential and gain competitive advantage is becoming as crucial as economic evaluation. In addition, the impact on human operators and skill level required must be considered. This research was motivated by the lack of decision methodologies that understand why a technology is more successful within an environment rather than re-examining the underlying performance attributes of a technology. The aim is to create a common approach where both experts and non-experts can use historical decision information to support the evaluation and selection of an optimal manufacturing technology. This form of approach is based on the logic in which a decision maker would irrationally recall previous decisions to identify relationships with new problem cases. The work investigates data mining and machine learning techniques to discover the underlying influences to improve technology selection under a set of dynamic factors. The approach initially discovers the practices to which an expert would conduct the selection of a manufacturing technology within industry. A defined understanding of the problem and techniques was subsequently concluded. This led to an understanding of the str
28. Experience-based decision support methodology for manufacturing technology selection: a fuzzy-decision-tree mining approach
- Author
-
Evans, Liam and Evans, Liam
- Abstract
Manufacturing companies must invest in new technologies and processes to succeed in a rapidly changing global environment. Managers have the difficulty of justifying capital investment in adopting new, state-of-the-art technology. Technology investment accounts for a large part of capital spending and is a key form of improving competitive advantage. Typical approaches focus on the expected return of investment and financial reward gained from the implementation of such equipment. With an increasingly dynamic market environment and global economic model, forecasting of financial payback can be argued to become increasingly less accurate. Subsequently, less quantifiable factors are becoming increasingly important. For example, the alignment of a technology with an organisations objective to fulfil future potential and gain competitive advantage is becoming as crucial as economic evaluation. In addition, the impact on human operators and skill level required must be considered. This research was motivated by the lack of decision methodologies that understand why a technology is more successful within an environment rather than re-examining the underlying performance attributes of a technology. The aim is to create a common approach where both experts and non-experts can use historical decision information to support the evaluation and selection of an optimal manufacturing technology. This form of approach is based on the logic in which a decision maker would irrationally recall previous decisions to identify relationships with new problem cases. The work investigates data mining and machine learning techniques to discover the underlying influences to improve technology selection under a set of dynamic factors. The approach initially discovers the practices to which an expert would conduct the selection of a manufacturing technology within industry. A defined understanding of the problem and techniques was subsequently concluded. This led to an understanding of the str
29. Creating smart cities
- Author
-
Kitchin R, Coletta C, Evans L, Heaphy L, Claudio Coletta, Leighton Evans, Liam Heaphy, Rob Kitchin, Kitchin R, Coletta C, Evans L, and Heaphy L
- Subjects
Smart Cities, citizenship, governance, case tudies - Abstract
In cities around the world, digital technologies are utilized to manage city services and infrastructures, to govern urban life, to solve urban issues and to drive local and regional economies. While “smart city” advocates are keen to promote the benefits of smart urbanism – increased efficiency, sustainability, resilience, competitiveness, safety and security – critics point to the negative effects, such as the production of technocratic governance, the corporatization of urban services, technological lock-ins, privacy harms, and vulnerability to cyberattack. This book, through a range of international case studies, suggests social, political and practical interventions that would enable more equitable and just smart cities, reaping the benefits of smart city initiatives while minimizing some of their perils. Included are case studies from Ireland, the United States of America, Colombia, the Netherlands, Singapore, India and the United Kingdom. These essays discuss a range of issues including political economy, citizenship, standards, testbedding, urban regeneration, ethics, surveillance, privacy and cybersecurity. This book will be of interest to urban policymakers, as well as researchers in Regional Studies and Urban Planning.
- Published
- 2018
30. An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience.
- Author
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Vicidomini C, Goode TD, McAvoy KM, Yu R, Beveridge CH, Iyer SN, Victor MB, Leary N, Evans L, Steinbaugh MJ, Lai ZW, Lyon MC, Silvestre MRFS, Bonilla G, Sadreyev RI, Walther TC, Sui SH, Saido T, Yamamoto K, Murakami M, Tsai LH, Chopra G, and Sahay A
- Abstract
Breakdown of lipid homeostasis is thought to contribute to pathological aging, the largest risk factor for neurodegenerative disorders such as Alzheimer's Disease (AD). Cognitive reserve theory posits a role for compensatory mechanisms in the aging brain in preserving neuronal circuit functions, staving off cognitive decline, and mitigating risk for AD. However, the identities of such mechanisms have remained elusive. A screen for hippocampal dentate granule cell (DGC) synapse loss-induced factors identified a secreted phospholipase , Pla2g2f , whose expression increases in DGCs during aging. Pla2g2f deletion in DGCs exacerbates aging-associated pathophysiological changes including synapse loss, inflammatory microglia, reactive astrogliosis, impaired neurogenesis, lipid dysregulation and hippocampal-dependent memory loss. Conversely, boosting Pla2g2f in DGCs during aging is sufficient to preserve synapses, reduce inflammatory microglia and reactive gliosis, prevent hippocampal-dependent memory impairment and modify trajectory of cognitive decline. Ex vivo, neuronal-PLA2G2F mediates intercellular signaling to decrease lipid droplet burden in microglia. Boosting Pla2g2f expression in DGCs of an aging-sensitive AD model reduces amyloid load and improves memory. Our findings implicate PLA2G2F as a compensatory neuroprotective factor that maintains lipid homeostasis to counteract aging-associated cognitive decline.
- Published
- 2024
- Full Text
- View/download PDF
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