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1. Evaluation of selection strategies in dual-purpose and specialized breeding of indigenous chicken

Author: Sophie Miyumo, Chrilukovian B. Wasike, Evans D. Ilatsia, Jörn Bennewitz, and Mizeck G.G. Chagunda
Subjects: indigenous chicken, selection strategy, dual-purpose breed, specialized breed, Animal culture, SF1-1100
Abstract: ABSTRACT: This study aimed to evaluate various selection strategies for adoption in dual-purpose (ICD), meat (ICM) and layer (ICL) breeding goals in indigenous chicken breeding programs. The ICM goal aimed to improve live weight (LW12), daily gain (ADG) and egg weight (EW12) or together with feed efficiency and antibody response. For the ICL goal, age at first egg (AFE) and egg number (EN12) or together with feed efficiency and antibody response were targeted. In the ICD goal, the objective was to improve LW12, ADG, AFE and EN12 or together with feed efficiency and antibody response. Highest total index responses of US$ 49.83, US$ 65.71, and US$ 37.90 were estimated in indices targeting only production traits in the ICD, ICM and ICL goals, respectively. Highest index accuracy estimates of 0.77 and 0.70 were observed in indices that considered production and feed-related traits in the ICD and ICL goals, respectively, while in the ICM goal, the highest estimate of 0.96 was observed in an index targeting only production traits. Inbreeding levels ranged from 0.60 to 1.14% across the various indices considered in the breeding goals. Targeting only production traits in the ICD, ICM and ICL goals required the least number of generations of selection of 7.46, 5.50, and 8.52, respectively, to achieve predefined gains. Generally, a strategy targeting only production traits in a goal was the most optimal but resulted to unfavorable correlated responses in feed efficiency and antibody response. Addition of feed efficiency or/and antibody response in a goal was, however, not attractive due to the decline in total index response and accuracy and increase in inbreeding levels and number of generations of selection. Considering the feed availability and disease challenges in the tropics, choice of including feed efficiency or/and antibody response in the ICD, ICM and ICL goals should depend on targeted production system, resource availability to support breeding activities and magnitude of correlated responses on these traits when not included in the goals.
Published: 2024
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2. Genetic and phenotypic correlations among feed efficiency, immune and production traits in indigenous chicken of Kenya

Author: Sophie A. Miyumo, Chrilukovian B. Wasike, Evans D. Ilatsia, Jorn Bennewitz, and Mizeck G. G. Chagunda
Subjects: indigenous chicken, feed efficiency, immunity, production, genetic parameters, Genetics, QH426-470
Abstract: This study aimed at estimating genetic and phenotypic relationships among feed efficiency, immune and production traits measured pre- (9–20 weeks of age) and post- (12 weeks from on-set of lay) maturity. Production traits were average daily gain (ADG) and average daily feed-intake (ADFI1) in the pre-maturity period and age at first egg (AFE), average daily feed-intake (ADFI2) and average daily egg mass (EM) in the post-maturity period. Feed efficiency comprised of residual feed intake (RFI) estimated in both periods. Natural antibodies binding to keyhole limpet hemocyanin (KLH-IgM) and specific antibodies binding to Newcastle disease virus (NDV-IgG) measured at 16 and 28 weeks of age represented immune traits pre- and post-maturity, respectively. In the growing period, 1,820 records on ADG, KLH-IgM and NDV-IgG, and 1,559 records on ADFI1 and RFI were available for analyses. In the laying period, 1,340 records on AFE, EM, KLH-IgM and NDV-IgG, and 1,288 records on ADFI2 and RFI were used in the analyses. Bi-variate animal mixed model was fitted to estimate (co)variance components, heritability and correlations among the traits. The model constituted sex, population, generation, line and genotype as fixed effects, and animal and residual effects as random variables. During the growing period, moderate to high heritability (0.36–0.68) was estimated for the production traits and RFI while the antibody traits had low (0.10–0.22) heritability estimates. Post-maturity, the production traits and RFI were moderately (0.30–0.37) heritable while moderate to high (0.25–0.41) heritability was estimated for the antibody traits. Genetic correlations between feed efficiency and production traits in both periods showed that RFI had negative genetic correlations with ADG (−0.47) and EM (−0.56) but was positively correlated with ADFI1 (0.60), ADFI2 (0.74) and AFE (0.35). Among immune and production traits, KLH-IgM and NDV-IgG had negative genetic correlations with ADG (−0.22; −0.56), AFE (−0.39; −0.42) and EM (−0.35; −0.16) but were positively correlated with ADFI1 (0.41; 0.34) and ADFI2 (0.47; 0.52). Genetic correlations between RFI with KLH-IgM (0.62; 0.33) and NDV-IgG (0.58; 0.50) were positive in both production periods. Feed intake, RFI and antibody traits measured in both production periods were positively correlated with estimates ranging from 0.48 to 0.82. Results from this study indicate selection possibilities to improve production, feed efficiency and immune-competence in indigenous chicken. The genetic correlations suggest that improved feed efficiency would be associated with high growth rates, early maturing chicken, high egg mass and reduced feed intake. In contrast, improved general (KLH-IgM) and specific (NDV-IgG) immunity would result in lower growth rates and egg mass but associated with early sexual maturation and high feed intake. Unfavorable genetic correlations between feed efficiency and immune traits imply that chicken of higher productivity and antibody levels will consume more feed to support both functions. These associations indicate that selective breeding for feed efficiency and immune-competence may have genetic consequences on production traits and should therefore be accounted for in indigenous chicken improvement programs
Published: 2023
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3. Comparing Health Administrative and Clinical Registry Data: Trends in Incidence and Prevalence of Pediatric Inflammatory Bowel Disease in British Columbia

Author: Chan JM, Carroll MW, Smyth M, Hamilton Z, Evans D, McGrail K, Benchimol EI, and Jacobson K
Subjects: crohn’s disease, ulcerative colitis, pediatric, health administrative data, clinical registry, Infectious and parasitic diseases, RC109-216
Abstract: Justin M Chan,1,2 Matthew W Carroll,3 Matthew Smyth,4 Zachary Hamilton,2 Dewey Evans,2 Kimberlyn McGrail,5 Eric I Benchimol,6 Kevan Jacobson1,2,4 1Department of Pediatrics, BC Children’s Hospital, Vancouver, British Columbia, Canada; 2BC Children’s Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; 3Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada; 4Division of Gastroenterology, Hepatology and Nutrition, BC Children’s Hospital, Vancouver, British Columbia, Canada; 5Centre for Health Services and Policy Research, University of British Columbia, Vancouver, British Columbia, Canada; 6Division of Gastroenterology, CHEO Inflammatory Bowel Disease Centre and University of Ottawa, Ottawa, Ontario, CanadaCorrespondence: Kevan JacobsonDepartment of Pediatrics, BC Children’s Hospital, 4480 Oak Street, Vancouver, BC, V6H 3V4, CanadaTel +1-(604)-875-2332 Ext 1Email kjacobson@cw.bc.caPurpose: Canada maintains robust health administrative databases and British Columbia Children’s Hospital (BCCH), as the only tertiary care pediatric hospital in British Columbia (BC), maintains a comprehensive clinical inflammatory bowel disease (IBD) registry. To evaluate the strengths and weaknesses of utilizing health administrative and clinical registry data to study the epidemiology of IBD in BC, we conducted a population-based retrospective cohort study of all children < 18 years of age who were diagnosed with IBD between 1996 and 2008 in BC.Methods: IBD cases from health administrative data were identified using a combination of IBD-coded physician encounters and hospitalizations while a separate IBD cohort was identified from the BCCH clinical registry data. Age and gender standardized incidence and prevalence rates were fitted to Poisson regression models.Results: The overall incidence of pediatric IBD identified in health administrative data increased from 7.1 (95% CI 5.5– 9.2) in 1996 to 10.3 (95% CI 8.2– 12.7) per 100,000 children in 2008. Similarly, the incidence of the BCCH cohort increased from 4.3 (95% CI 3.0– 6.0) to 9.7 (95% CI 7.6– 12.1) per 100,000. Children aged 10– 17 had the highest rise in incidence in both data sources; however, the administrative data identified significantly more 10– 17-year-olds and significantly less 6– 9-year-olds (p< 0.05) compared to clinical registry data.Conclusion: While the application of both health administrative and clinical registry data demonstrates that the incidence of IBD is increasing in BC, we identify strengths and limitations to both and suggest that the utilization of either data source requires unique considerations that mitigate misclassification biases.Keywords: Crohn’s disease, ulcerative colitis, pediatric, health administrative data, clinical registry
Published: 2021

4. Selection Signature Analyses Revealed Genes Associated With Adaptation, Production, and Reproduction in Selected Goat Breeds in Kenya

Author: Ruth W. Waineina, Tobias O. Okeno, Evans D. Ilatsia, and Kiplangat Ngeno
Subjects: adaptation, candidate genes, footprints, signature of selection, putative regions, Genetics, QH426-470
Abstract: Artificial and natural selection in livestock is expected to leave unique footprints on their genomes. Goat breeds in Kenya have evolved for survival, breeding, and production in various harsh ecological areas, and their genomes are likely to have acquired unique alleles for adaptation to such diverse production environments and other traits of economic importance. To investigate signals of selection for some selected goat breeds in Kenya, Alpine (n = 29), Galla (n = 12), Saanen (n = 24), and Toggenburg (n = 31) were considered. A total of 53,347 single-nucleotide polymorphisms (SNPs) generated using the Illumina GoatSNP50 BeadChip were analyzed. After quality control, 47,663 autosomal single-nucleotide polymorphisms remained for downstream analyses. Several complementary approaches were applied for the following analyses: integrated Haplotype Score (iHS), cross-population-extended haplotype homozygosity (XP-EHH), hapFLK, and FLK. A total of 404 top genomic regions were identified across all the four breeds, based on the four complementary analyses. Out of the 16 identified putative selection signature regions by the intersection of multiple-selective signal analyses, most of the putative regions were found to overlap significantly with the iHS and XP-EHH analyses on chromosomes 3, 4, 10, 15, 22, and 26. These regions were enriched with some genes involved in pathways associated directly or indirectly with environmental adaptation regulating immune responses (e.g., HYAL1 and HYAL3), milk production (e.g., LEPR and PDE4B), and adaptability (e.g., MST1 and PCK). The results revealed few intersect between breeds in genomic selection signature regions. In general, this did not present the typical classic selection signatures as predicted due to the complex nature of the traits. The results support that some various selection pressures (e.g., environmental challenges, artificial selection, and genome admixture challenges) have molded the genome of goat breeds in Kenya. Therefore, the research provides new knowledge on the conservation and utilization of these goat genetic resources in Kenya. In-depth research is needed to detect precise genes connected with adaptation and production in goat breeds in Kenya.
Published: 2022
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5. Using a Self-Administered Electronic Adherence Questionnaire to Identify Poor Adherence Amongst Adolescents and Young Adults on First-Line Antiretroviral Therapy in Johannesburg, South Africa

Author: Hirasen K, Evans D, Jinga N, Grabe R, Turner J, Mashamaite S, Long LC, and Fox MP
Subjects: antiretroviral therapy, adherence, adolescents, virologic suppression, therapeutic drug monitoring, south africa, Medicine (General), R5-920
Abstract: Kamban Hirasen,1,* Denise Evans,1,* Nelly Jinga,1 Rita Grabe,2 Julia Turner,2 Sello Mashamaite,2 Lawrence C Long,1,3 Matthew P Fox1,3,4 1Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 2Right to Care, Johannesburg, South Africa; 3Department of Global Health, Boston University School of Public Health, Boston, MA, USA; 4Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA*These authors contributed equally to this workCorrespondence: Denise Evans Tel +27 10 001 0637Email devans@heroza.orgIntroduction: The best method to measure adherence to antiretroviral therapy (ART) in resource-limited settings has not yet been established, particularly among adolescents and young adults (AYAs). The use of mobile technology may address the need for standardized tools in measuring adherence in this often marginalized population.Methods: We conducted a cross-sectional validation study among AYAs (18– 35 years) attending a South African HIV clinic between 07/2015-09/2017. We determine the diagnostic accuracy of two modes of delivering an adherence questionnaire (self-administered electronic vs interviewer-administered paper-adherence questionnaire) comprising two self-reported adherence tools (South African National Department of Health (NDoH) adherence questionnaire and the Simplified Medication Adherence Questionnaire (SMAQ)) to identify poor adherence compared to; 1) a detectable viral load (≥ 1000 copies/mL) and 2) a sub-optimal concentration of efavirenz (EFV) (EFV ≤ 1.00 μg/mL) measured by therapeutic drug monitoring (TDM).Results: Of 278 included participants, 7.1% and 7.3% completing the electronic- and paper-questionnaires had a detectable viral load, while 14.7% and 16.5% had a sub-optimal concentration of EFV, respectively. According to viral load monitoring, the electronic-adherence questionnaire had a higher sensitivity (Se) in detecting poor adherence than the paper-based version across the NDoH adherence questionnaire (Se: 63.6% vs 33.3%) and SMAQ (Se: 90.9% vs 66.7%). In contrast, when using blood drug concentration (EFV ≤ 1.00 μg/mL), the paper-adherence questionnaire produced a higher sensitivity across both adherence tools; namely the NDoH adherence questionnaire (Se: 50.0% vs 38.1%) and SMAQ (Se: 75.0% vs 57.1%).Conclusion: When using more accurate real-time measures of poor adherence such as TDM in this young adult population, we observe a higher sensitivity of an interviewer-administered paper-adherence questionnaire than an identical set of self-administered adherence questions on an electronic tablet. An interviewer-administered questionnaire may elicit more accurate responses from participants through a sense of increased accountability when engaging with health care workers.Keywords: antiretroviral therapy, adherence, adolescents, virologic suppression, therapeutic drug monitoring, South Africa
Published: 2020

6. Sensitivity studies on a novel nuclear forensics methodology for source reactor-type discrimination of separated weapons grade plutonium

Author: Evans D. Kitcher, Jeremy M. Osborn, and Sunil S. Chirayath
Subjects: Nuclear engineering. Atomic power, TK9001-9401
Abstract: A recently published nuclear forensics methodology for source discrimination of separated weapons-grade plutonium utilizes intra-element isotope ratios and a maximum likelihood formulation to identify the most likely source reactor-type, fuel burnup and time since irradiation of unknown material. Sensitivity studies performed here on the effects of random measurement error and the uncertainty in intra-element isotope ratio values show that different intra-element isotope ratios have disproportionate contributions to the determination of the reactor parameters. The methodology is robust to individual errors in measured intra-element isotope ratio values and even more so for uniform systematic errors due to competing effects on the predictions from the selected intra-element isotope ratios suite. For a unique sample-model pair, simulation uncertainties of up to 28% are acceptable without impeding successful source-reactor discrimination. However, for a generic sample with multiple plausible sources within the reactor library, uncertainties of 7% or less may be required. The results confirm the critical role of accurate reactor core physics, fuel burnup simulations and experimental measurements in the proposed methodology where increased simulation uncertainty is found to significantly affect the capability to discriminate between the reactors in the library. Keywords: Nuclear forensics, Reactor-type discrimination, Maximum likelihood, Intra-element isotope ratios, Sensitivity analysis
Published: 2019
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7. Clinical predictor score to identify patients at risk of poor viral load suppression at six months on antiretroviral therapy: results from a prospective cohort study in Johannesburg, South Africa

Author: Mbengue MAS, Chasela C, Onoya D, Mboup S, Fox MP, and Evans D
Subjects: Antiretroviral therapy, viral load, monitoring, risk score, algorithm, resource limited, Infectious and parasitic diseases, RC109-216
Abstract: Mouhamed Abdou Salam Mbengue,1,2 Charles Chasela,1,3 Dorina Onoya,4 Souleymane Mboup,2 Matthew P Fox,5,6 Denise Evans41Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 2Department of Biostatistics and Health Economics, IRESSEF: Institute of Health Research, Epidemiologic Surveillance and Training, Dakar, Senegal; 3Epidemiology and Strategic Information, HIV/AIDS, STIs & TB, Human Sciences Research Council, Pretoria, South Africa; 4Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 5Department of Global Health, Boston University School of Public Health, Boston, MA, USA; 6Department of Epidemiology, Boston University School of Public Health, Boston, MA, USAPurpose: As countries work toward 90:90:90 targets, early identification of patients with inadequate response to antiretroviral therapy (ART) is critical for achieving optimal HIV treatment outcomes. We developed and evaluated a clinical prediction score (CPS) to identify HIV-positive patients at risk of poor viral load suppression at 6 months on ART.Patients and methods: We conducted a prospective cohort study of HIV-positive ART naïve adults (≥18 years) initiating standard first-line ART between February 2012 and April 2014 at Themba Lethu Clinic in Johannesburg, South Africa. We used Modified Poisson regression to estimate the association between patient characteristics and poor viral load suppression, defined as a viral load ≥400 copies/mL at 6 months on ART. We developed a CPS following the Spiegel Halter and Knill-Jones approach and determined the diagnostic accuracy compared to viral load as the “gold standard”. We identified the optimal cutoff at which the CPS would identify those at risk of poor viral load suppression.Results: Among 353 patients, 67.7% had a viral load measurement at 6 months on ART and 30.1% of these were viremic (≥400 copies/mL). Male gender, platelet count
Published: 2019

8. A phase 1, open-label, single-arm study evaluating the ocular safety of OTX-101 and systemic absorption of cyclosporine in healthy human volunteers

Author: Karpecki PM, Weiss SL, Kramer WG, O'Connor P, Evans D, Johnston J, Jasper AL, Justice A, Ogundele AB, and Devries D
Subjects: dry eye disease, cyclosporine, pharmacokinetic, systemic exposure, Ophthalmology, RE1-994
Abstract: Paul M Karpecki,1,2 Sidney L Weiss,3 William G Kramer,4 Patrick O’Connor,5 David Evans,6 Josh Johnston,7 April L Jasper,8 Angela Justice,9 Abayomi B Ogundele,9 Doug Devries10 1Kentucky Eye Institute, Lexington, KY, USA; 2Gaddie Eye Centers, Louisville, KY, USA; 3i-novion, Inc., Randolph, NJ, USA; 4Kramer Consulting, LLC, North Potomac, MD, USA; 5Auven Therapeutics, Delray Beach, FL, USA; 6Total Eye Care, Memphis, TN, USA; 7Georgia Eye Partners, Atlanta, GA, USA; 8Advanced Eyecare Specialists, West Palm Beach, FL, USA; 9Sun Ophthalmics, Sun Pharmaceutical Industries, Ltd., Princeton, NJ, USA; 10Eye Care Associates of Nevada, Sparks, NV, USA Purpose: To evaluate the ocular safety of OTX-101 0.09% – a novel, nanomicellar, clear, aqueous solution of cyclosporine (CsA) – and to determine the systemic exposure to CsA following ophthalmic administration. Patients and methods: Healthy volunteers ≥18 years of age were recruited for participation in this phase 1, open-label, single-center, single-arm, study. Subjects received one drop of OTX-101 0.09% in each eye every 12 hours for 7 days, and once on day 8. Blood samples were collected predose, and 0.25, 0.5, 1, 2, 4, 8, and 12 hours post-first dose on day 1 and day 8. CsA levels in whole blood samples were analyzed using liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters (maximal whole blood concentration [Cmax, ng/mL], time to Cmax [Tmax, hours]), and area under the concentration-time curve from 0 to the last measurement [AUC(0–t), h·ng/mL]) were calculated using noncompartmental analysis. Safety assessments included subject-reported adverse events (AEs), vital signs, visual acuity, intraocular pressure measurement, biomicroscopy, and direct ophthalmoscopy. Results: A total of 16 subjects were enrolled; 15 subjects completed the study. Blood sample analysis indicated limited systemic exposure to CsA; three subjects had a CsA concentration greater than or equal to the lower limit of quantitation (LLOQ) on day 1; only four subjects had three consecutive CsA concentration measurements ≥LLOQ on day 8; the mean±SD for Cmax was 0.17±0.02 ng/mL, Tmax was 1.5±0.58 hours, and AUC(0–t) was 0.53±0.06 h·ng/mL. Three subjects reported three AEs (eye pain, eye pruritis, and eye irritation) during the study. No clinically significant changes in the safety assessments were noted. Conclusion: The OTX-101 formulation was well tolerated. Systemic exposure to CsA was negligible in healthy volunteers after twice-daily ocular administration. No evidence for systemic accumulation of CsA was observed. Keywords: dry eye disease, cyclosporine, pharmacokinetic, systemic exposure
Published: 2019

9. Experimental validation of a nuclear forensics methodology for source reactor-type discrimination of chemically separated plutonium

Author: Jeremy M. Osborn, Kevin J. Glennon, Evans D. Kitcher, Jonathan D. Burns, Charles M. Folden, III, and Sunil S. Chirayath
Subjects: Nuclear engineering. Atomic power, TK9001-9401
Abstract: An experimental validation of a nuclear forensics methodology for the source reactor-type discrimination of separated weapons-useable plutonium is presented. The methodology uses measured values of intra-element isotope ratios of plutonium and fission product contaminants. MCNP radiation transport codes were used for various reactor core modeling and fuel burnup simulations. A reactor-dependent library of intra-element isotope ratio values as a function of burnup and time since irradiation was created from the simulation results. The experimental validation of the methodology was achieved by performing two low-burnup experimental irradiations, resulting in distinct fuel samples containing sub-milligram quantities of weapons-useable plutonium. The irradiated samples were subjected to gamma and mass spectrometry to measure several intra-element isotope ratios. For each reactor in the library, a maximum likelihood calculation was utilized to compare the measured and simulated intra-element isotope ratio values, producing a likelihood value which is proportional to the probability of observing the measured ratio values, given a particular reactor in the library. The measured intra-element isotope ratio values of both irradiated samples and its comparison with the simulation predictions using maximum likelihood analyses are presented. The analyses validate the nuclear forensics methodology developed. Keywords: Nuclear forensics, Reactor-type discrimination, Weapons-useable plutonium, Intra-element isotope ratios, Maximum likelihood
Published: 2019
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10. Discovery of a dormant 33 solar-mass black hole in pre-release Gaia astrometry

Author: Gaia Collaboration, Panuzzo, P., Mazeh, T., Arenou, F., Holl, B., Caffau, E., Jorissen, A., Babusiaux, C., Gavras, P., Sahlmann, J., Bastian, U., Wyrzykowski, Ł., Eyer, L., Leclerc, N., Bauchet, N., Bombrun, A., Mowlavi, N., Seabroke, G. M., Teyssier, D., Balbinot, E., Helmi, A., Brown, A. G. A., Vallenari, A., Prusti, T., de Bruijne, J. H. J., Barbier, A., Biermann, M., Creevey, O. L., Ducourant, C., Evans, D. W., Guerra, R., Hutton, A., Jordi, C., Klioner, S. A., Lammers, U., Lindegren, L., Luri, X., Mignard, F., Nicolas, C., Randich, S., Sartoretti, P., Smiljanic, R., Tanga, P., Walton, N. A., Aerts, C., Bailer-Jones, C. A. L., Cropper, M., Drimmel, R., Jansen, F., Katz, D., Lattanzi, M. G., Soubiran, C., Thévenin, F., van Leeuwen, F., Andrae, R., Audard, M., Bakker, J., Blomme, R., Castañeda, J., De Angeli, F., Fabricius, C., Fouesneau, M., Frémat, Y., Galluccio, L., Guerrier, A., Heiter, U., Masana, E., Messineo, R., Nienartowicz, K., Pailler, F., Riclet, F., Roux, W., Sordo, R., Gracia-Abril, G., Portell, J., Altmann, M., Benson, K., Berthier, J., Burgess, P. W., Busonero, D., Busso, G., Cacciari, C., Cánovas, H., Carrasco, J. M., Carry, B., Cellino, A., Cheek, N., Clementini, G., Damerdji, Y., Davidson, M., de Teodoro, P., Delchambre, L., Dell'Oro, A., Garcia, E. Fraile, Garabato, D., García-Lario, P., Haigron, R., Hambly, N. C., Harrison, D. L., Hatzidimitriou, D., Hernández, J., Hestroffer, D., Hodgkin, S. T., Jamal, S., de Fombelle, G. Jevardat, Jordan, S., Krone-Martins, A., Lanzafame, A. C., Löffler, W., Lorca, A., Marchal, O., Marrese, P. M., Moitinho, A., Muinonen, K., Campos, M. Nuñez, Oreshina-Slezak, I., Osborne, P., Pancino, E., Pauwels, T., Recio-Blanco, A., Riello, M., Rimoldini, L., Robin, A. C., Roegiers, T., Sarro, L. M., Schultheis, M., Smith, M., Sozzetti, A., Utrilla, E., van Leeuwen, M., Weingrill, K., Abbas, U., Ábrahám, P., Aramburu, A. Abreu, Ahmed, S., Altavilla, G., Álvarez, M. A., Anders, F., Anderson, R. I., Varela, E. Anglada, Antoja, T., Baig, S., Baines, D., Baker, S. G., Balaguer-Núñez, L., Balog, Z., Barache, C., Barros, M., Barstow, M. A., Bartolomé, S., Bashi, D., Bassilana, J. -L., Baudeau, N., Becciani, U., Bedin, L. R., Bellas-Velidis, I., Bellazzini, M., Beordo, W., Bernet, M., Bertolotto, C., Bertone, S., Bianchi, L., Binnenfeld, A., Blanco-Cuaresma, S., Bland-Hawthorn, J., Blazere, A., Boch, T., Bossini, D., Bouquillon, S., Bragaglia, A., Braine, J., Bratsolis, E., Breedt, E., Bressan, A., Brouillet, N., Brugaletta, E., Bucciarelli, B., Butkevich, A. G., Buzzi, R., Camut, A., Cancelliere, R., Cantat-Gaudin, T., Guilarte, D. Capilla, Carballo, R., Carlucci, T., Carnerero, M. I., Carretero, J., Carton, S., Casamiquela, L., Casey, A., Castellani, M., Castro-Ginard, A., Ceraj, L., Cesare, V., Charlot, P., Chaudet, C., Chemin, L., Chiavassa, A., Chornay, N., Chosson, D., Cooper, W. J., Cornez, T., Cowell, S., Crosta, M., Crowley, C., Reyes, M. Cruz, Dafonte, C., Ponte, M. Dal, David, M., de Laverny, P., De Luise, F., De March, R., De Ridder, J., de Torres, A., del Peloso, E. F., Delbo, M., Delgado, A., Delisle, J. -B., Demouchy, C., Denis, E., Dharmawardena, T. E., Di Giacomo, F., Diener, C., Distefano, E., Dolding, C., Dsilva, K., Enke, H., Fabre, C., Fabrizio, M., Faigler, S., Fatović, M., Fedorets, G., Fernández-Hernández, J., Fernique, P., Figueras, F., Fouron, C., Fragkoudi, F., Gai, M., Galinier, M., Garcia-Serrano, A., García-Torres, M., Garofalo, A., Gerlach, E., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Gomboc, A., Gomez, A., González-Santamaría, I., Gosset, E., Granvik, M., Barrera, V. Gregori, Gutiérrez-Sánchez, R., Haywood, M., Helmer, A., Hidalgo, S. L., Hilger, T., Hobbs, D., Hottier, C., Huckle, H. E., Jiménez-Arranz, Ó., Campillo, J. Juaristi, Kaczmarek, Z., Kervella, P., Khanna, S., Kontizas, M., Kordopatis, G., Korn, A. J., Kóspál, Á, Kostrzewa-Rutkowska, Z., Kruszyńska, K., Kun, M., Lambert, S., Lanza, A. F., Lebreton, Y., Lebzelter, T., Leccia, S., Lecoutre, G., Liao, S., Liberato, L., Licata, E., Livanou, E., Lobel, A., López-Miralles, J., Loup, C., Madarász, M., Mahy, L., Mann, R. G., Manteiga, M., Marinoni, S., Marcellino, C. P., Marshall, D. J., Mascarenhas, D., Marchant, J. M., Lozano, J. Martín, Masip, A., Marconi, M., Pina, D. Marín, Polo, L. Martin, Martín-Fleitas, J. M., Mastrobuono-Battisti, A., McMillan, P. J., Meichsner, J. G. Marton, Merc, J., Messina, S., Millar, N. R., Mints, A., Mohamed, D., Molina, D., Molinaro, R., Monguió, M., Montegriffo, P., Monti, L., Mora, A., Morbidelli, R., Morris, D., Mudimadugula, R., Muraveva, T., Musella, I., Nagy, Z., Nardetto, N., Navarrete, C., Oh, S., Ordenovic, C., Orenstein, O., Pagani, C., Pagano, I., Palaversa, L., Palicio, P. A., Pallas-Quintela, L., Pawlak, M., Penttilä, A., Pesciullesi, P., Pinamonti, M., Plachy, E., Planquart, L., Plum, G., Poggio, E., Pourbaix, D., Price-Whelan, A. M., Pulone, L., Rabin, V., Rainer, M., Raiteri, C. M., Ramos, P., Ramos-Lerate, M., Ratajczak, M., Fiorentin, P. Re, Regibo, S., Reylé, C., Ripepi, V., Riva, A., Rix, H. -W., Rixon, G., Robert, G., Robichon, N., Robin, C., Romero-Gómez, M., Rowell, N., Mieres, D. Ruz, Rybicki, K. A., Sadowski, G., Sellés, A. Sagristà, Sanna, N., Santoveña, R., Sarasso, M., Sarmiento, M. H., Riera, C. Sarrate, Sciacca, E., Ségransan, D., Semczuk, M., Shahaf, S., Siebert, A., Slezak18, E., Smart, R. L., Snaith, O. N., Solano, E., Solitro, F., Souami, D., Souchay, J., Spitoni, E., Spoto, F., Squillante, L. A., Steele, I. A., Steidelmüller, H., Surdej, J., Szabados, L., Taris, F., Taylor, M. B., Teixeira, R., Tepper-Garcia, T., Thuillot, W., Tolomei, L., Tonello, N., Torra, F., Elipe, G. Torralba, Trabucchi, M., Trentin, E., Tsantaki, M., Turon, C., Ulla, A., Unger, N., Valtchanov, I., Vanel, O., Vecchiato, A., Vicente, D., Villar, E., Weiler, M., Zhao, H., Zorec, J., Zucker, S., Župić, A., and Zwitter, T.
Subjects: Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract: Gravitational waves from black-hole merging events have revealed a population of extra-galactic BHs residing in short-period binaries with masses that are higher than expected based on most stellar evolution models - and also higher than known stellar-origin black holes in our Galaxy. It has been proposed that those high-mass BHs are the remnants of massive metal-poor stars. Gaia astrometry is expected to uncover many Galactic wide-binary systems containing dormant BHs, which may not have been detected before. The study of this population will provide new information on the BH-mass distribution in binaries and shed light on their formation mechanisms and progenitors. As part of the validation efforts in preparation for the fourth Gaia data release (DR4), we analysed the preliminary astrometric binary solutions, obtained by the Gaia Non-Single Star pipeline, to verify their significance and to minimise false-detection rates in high-mass-function orbital solutions. The astrometric binary solution of one source, Gaia BH3, implies the presence of a 32.70 \pm 0.82 M\odot BH in a binary system with a period of 11.6 yr. Gaia radial velocities independently validate the astrometric orbit. Broad-band photometric and spectroscopic data show that the visible component is an old, very metal-poor giant of the Galactic halo, at a distance of 590 pc. The BH in the Gaia BH3 system is more massive than any other Galactic stellar-origin BH known thus far. The low metallicity of the star companion supports the scenario that metal-poor massive stars are progenitors of the high-mass BHs detected by gravitational-wave telescopes. The Galactic orbit of the system and its metallicity indicate that it might belong to the Sequoia halo substructure. Alternatively, and more plausibly, it could belong to the ED-2 stream, which likely originated from a globular cluster that had been disrupted by the Milky Way., Comment: 23 pages, accepted fro publication in A&A Letters. New version with small fixes
Published: 2024
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11. Absolute dimensions of solar-type eclipsing binaries. NY Hya: A test for magnetic stellar evolution models

Author: Hinse, T. C., Baştürk, O., Southworth, J., Feiden, G. A., Tregloan-Reed, J., Kostov, V. B., Livingston, J., Esmer, E. M., Yılmaz, Mesut, Yalçınkaya, Selçuk, Torun, Şeyma, Vos, J., Evans, D. F., Morales, J. C., Wolf, J. C. A., Olsen, E. H., Clausen, J. V., Helt, B. E., Lý, C. T. K., Stahl, O., Wells, R., Herath, M., Jørgensen, U. G., Dominik, M., Skottfelt, J., Peixinho, N., Longa-Peña, P., Kim, Y., Kim, H. -E., Yoon, T. S., Alrebdi, H. I., and Zotos, E. E.
Subjects: Astrophysics - Solar and Stellar Astrophysics
Abstract: The binary star NY Hya is a bright, detached, double-lined eclipsing system with an orbital period of just under five days with two components each nearly identical to the Sun and located in the solar neighbourhood. The objective of this study is to test and confront various stellar evolution models for solar-type stars based on accurate measurements of stellar mass and radius. We present new ground-based spectroscopic and photometric as well as high-precision space-based photometric and astrometric data from which we derive orbital as well as physical properties of the components via the method of least-squares minimisation based on a standard binary model valid for two detached components. Classic statistical techniques were invoked to test the significance of model parameters. Additional empirical evidence was compiled from the public domain; the derived system properties were compared with archival broad-band photometry data enabling a measurement of the system's spectral energy distribution that allowed an independent estimate of stellar properties. We also utilised semi-empirical calibration methods to derive atmospheric properties from Str\"{o}mgren photometry and related colour indices. Data was used to confront the observed physical properties with classic and magnetic stellar evolution models., Comment: 34 pages, 19 figures, 13 tables, (accepted for publication in A&A)
Published: 2024

12. Genetic diversity and population structure among indigenous and imported goat breeds in Kenya

Author: Ruth W Waineina, Kiplangat Ngeno, Tobias O. Okeno, and Evans D. Ilatsia
Subjects: Admixed breeds, Breed relationship, Crossbred goats, gene introgression, heterozygosity, Genetics, QH426-470
Abstract: Population structure and relationship information among goats is critical for genetic improvement, utilization, and conservation. This study explored population structure and level of introgression among four goat breeds in Kenya: the indigenous Galla (n = 12) and three imported breeds, the Alpine (n = 29), Toggenburg (n = 31), and Saanen (n = 24). Genetic diversity was analyzed using four indices (polymorphic SNPs, mean allele frequency, observed and expected heterozygosity and inbreeding coefficient) within each breed. Population structure assessed using model-based clustering (ADMIXTURE) revealed four breeds according to their geographic regions in Kenya. Kenyan Alpine goats were the most admixed breed with about 10 % of its genome derived from Galla, 10 % and 6 % from Saanen and Toggenburg respectively. The association of Galla with other breeds was anticipated since the Galla breed was used as the founder population for crossbreeding with Saanen, Alpine and Toggenburg breeds. The relationship information evaluated by computing Reynolds genetic distance revealed five distinctive clusters: Alpine, Galla, Saanen, Toggenburg and some mixture of Alpine and Toggenburg. Saanen and Galla breeds seem to be the most genetically distinct among the sampled populations. The genetic variation among the goat populations observed will provide a good opportunity for sustainable utilization, conservation, and future genetic resource improvement programmes in goat breeds in Kenya.
Published: 2021
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13. Germline BRCA1/2 status and chemotherapy response score in high-grade serous ovarian cancer

Author: Morgan, Robert D., Wang, Xin, Barnes, Bethany M., Spurgeon, Laura, Carrot, Aurore, Netto, Daniel, Hasan, Jurjees, Mitchell, Claire, Salih, Zena, Desai, Sudha, Shaw, Joseph, Winter-Roach, Brett, Schlecht, Helene, Burghel, George J., Clamp, Andrew R., Edmondson, Richard J., You, Benoit, Evans, D. Gareth R., Jayson, Gordon C., and Taylor, Stephen S.
Published: 2024
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14. BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial

Author: Torr, Bethany, Jones, Christopher, Kavanaugh, Grace, Hamill, Monica, Allen, Sophie, Choi, Subin, Garrett, Alice, Valganon-Petrizan, Mikel, MacMahon, Suzanne, Yuan, Lina, Way, Rosalind, Harder, Helena, Gold, Rochelle, Taylor, Amy, Gabe, Rhian, Lucassen, Anneke, Manchanda, Ranjit, Fallowfield, Lesley, Jenkins, Valerie, Gandhi, Ashu, Evans, D. Gareth, George, Angela, Hubank, Michael, Kemp, Zoe, Bremner, Stephen, and Turnbull, Clare
Published: 2024
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15. Computational and experimental forensics characterization of weapons-grade plutonium produced in a thermal neutron environment

Author: Jeremy M. Osborn, Kevin J. Glennon, Evans D. Kitcher, Jonathan D. Burns, Charles M. Folden, III, and Sunil S. Chirayath
Subjects: Nuclear engineering. Atomic power, TK9001-9401
Abstract: The growing nuclear threat has amplified the need for developing diverse and accurate nuclear forensics analysis techniques to strengthen nuclear security measures. The work presented here is part of a research effort focused on developing a methodology for reactor-type discrimination of weapons-grade plutonium. To verify the developed methodology, natural UO2 fuel samples were irradiated in a thermal neutron spectrum at the University of Missouri Research Reactor (MURR) and produced approximately 20 μg of weapons-grade plutonium test material. Radiation transport simulations of common thermal reactor types that can produce weapons-grade plutonium were performed, and the results are presented here. These simulations were needed to verify whether the plutonium produced in the natural UO2 fuel samples during the experimental irradiation at MURR was a suitable representative to plutonium produced in common thermal reactor types. Also presented are comparisons of fission product and plutonium concentrations obtained from computational simulations of the experimental irradiation at MURR to the nondestructive and destructive measurements of the irradiated natural UO2 fuel samples. Gamma spectroscopy measurements of radioactive fission products were mostly within 10%, mass spectroscopy measurements of the total plutonium mass were within 4%, and mass spectroscopy measurements of stable fission products were mostly within 5%. Keywords: Neutron Irradiation, Nuclear Forensics, Weapons-grade Plutonium
Published: 2018
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16. Magnetoelectric coupling at the domain level in polycrystalline ErMnO3

Author: Schultheiß, J., Puntigam, L., Winkler, M., Krohns, S., Meier, D., Das, H., Evans, D. M., and Kézsmárki, I.
Subjects: Condensed Matter - Materials Science
Abstract: We explore the impact of a magnetic field on the ferroelectric domain pattern in polycrystalline hexagonal ErMnO3 at cryogenic temperatures. Utilizing piezoelectric force microscopy measurements at 1.65 K, we observe modifications of the topologically protected ferroelectric domain structure induced by the magnetic field. These alterations likely result from strain induced by the magnetic field, facilitated by intergranular coupling in polycrystalline multiferroics. Our findings give insights into the interplay between electric and magnetic properties at the local scale and represent a so far unexplored pathway for manipulating topologically protected ferroelectric vortex patterns in hexagonal manganites.
Published: 2024

17. Post-synthesis tuning of dielectric constant via ferroelectric domain wall engineering

Author: Zhou, L., Puntigam, L., Lunkenheimer, P., Bourret, E., Yan, Z., Kézsmárki, I., Meier, D., Krohns, S., Schultheiß, J., and Evans, D. M.
Subjects: Condensed Matter - Materials Science
Abstract: A promising mechanism for achieving colossal dielectric constants is to use insulating internal barrier layers, which typically form during synthesis and then remain in the material. It has recently been shown that insulating domain walls in ferroelectrics can act as such barriers. One advantage domain walls have, in comparison to stationary interfaces, is that they can be moved, offering the potential of post-synthesis control of the dielectric constant. However, to date, direct imaging of how changes in domain wall pattern cause a change in dielectric constant within a single sample has not been realized. In this work, we demonstrate that changing the domain wall density allows the engineering of the dielectric constant in hexagonal-ErMnO3 single crystals. The changes of the domain wall density are quantified via microscopy techniques, while the dielectric constant is determined via macroscopic dielectric spectroscopy measurements. The observed changes in the dielectric constant are quantitatively consistent with the observed variation in domain wall density, implying that the insulating domain walls behave as 'ideal' capacitors connected in series. Our approach to engineer the domain wall density can be readily extended to other control methods, e.g., electric fields or mechanical stresses, providing a novel degree of flexibility to in-situ tune the dielectric constant.
Published: 2024
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18. The right combination – treatment outcomes among HIV-positive patients initiating first-line fixed-dose antiretroviral therapy in a public sector HIV clinic in Johannesburg, South Africa

Author: Hirasen K, Evans D, Maskew M, Sanne IM, Shearer K, Govathson C, Malete G, Kluberg SA, and Fox MP
Subjects: Antiretroviral therapy, Fixed-dose combination, Attrition, Virologic suppression, Adherence, South Africa, Infectious and parasitic diseases, RC109-216
Abstract: Kamban Hirasen,1 Denise Evans,1 Mhairi Maskew,1 Ian M Sanne,1–3 Kate Shearer,1 Caroline Govathson,1 Given Malete,1 Sheryl A Kluberg,4 Matthew P Fox1,4,51Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 2Right to Care, Johannesburg, South Africa; 3Clinical HIV Research Unit, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 4Department of Global Health, Boston University School of Public Health, Boston, MA, USA; 5Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA Background: Long-term antiretroviral therapy (ART) adherence is critical for achieving optimal HIV treatment outcomes. Fixed-dose combination (FDC) single-pill regimens, introduced in South Africa in April 2013, has simplified pill taking. We evaluated treatment outcomes among patients initiated on a FDC compared to a similar multi-pill ART regimen in Johannesburg, South Africa.Methods: We conducted a retrospective cohort study of ART-naïve HIV-positive non-pregnant adult (≥18 years) patients without tuberculosis who initiated first-line ART on tenofovir and emtricitabine or lamivudine with efavirenz at Themba Lethu Clinic in Johannesburg, South Africa. We compared those initiated on a multi-pill ART regimen (3–5 pills/day; September 1, 2011–August 31, 2012) to those initiated on a FDC ART regimen (one pill/day; September 1, 2013–August 31, 2014). Treatment outcomes included attrition (combination of lost to follow-up and mortality), missed medical visits, and virologic suppression (viral load
Published: 2017

19. Prevalence of Asymptomatic Malaria among Children in the Tamale Metropolis: How Does the PfHRP2 CareStart™ RDT Perform against Microscopy?

Author: Osman N. Kanwugu, Gideon K. Helegbe, Paul A. Aryee, Abass Abdul-Karim, Frank Anaba, Zulka Ziblim, and Evans D. Amevi
Subjects: Arctic medicine. Tropical medicine, RC955-962
Abstract: Background. Asymptomatic carriage of the malaria parasites, likewise its misdiagnosis, especially false negatives, due to the use of substandard rapid diagnosis tests (RDTs) has been shown to hinder the progress of the fight against malaria. Method. The study assessed the prevalence of asymptomatic malaria as well as the performance of Plasmodium falciparum-specific protein and histidine-rich protein 2 (PfHRP2) CareStart™ RDT against standard microscopy in the detection of malaria infection among 345 children (1–15 yrs) from two (2) basic schools in Tamale Metropolis. Results. From the microscopy (considered as gold standard), prevalence of malaria among the asymptomatic children was found to be 2.6%, with sensitivity and specificity of CareStart™ RDT in detecting P. falciparum infections found to be 55.6% and 93.8%, respectively. The positive predictive value (PPV) and negative predictive value (NPV) of CareStart™ RDT were found to be 19.23% and 98.45%, respectively. There was an evidence showing a significant relation between CareStart™ RDT and microscopy in determining malaria infection (χ2 = 30.579, p
Published: 2019
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20. Progress towards ultracold Sr for the AION project -- sub-microkelvin atoms and an optical-heterodyne diagnostic tool for injection-locked laser diodes

Author: Pasatembou, E., Baynham, C. F. A., Buchmüller, O., Evans, D., Hobson, R., Iannizzotto-Venezze, L., and Josset, A.
Subjects: Physics - Atomic Physics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors, Quantum Physics
Abstract: Long-baseline atom interferometers, such as the one to be built by the AION collaboration, require ultra-cold atomic clouds. These are produced by trapping the atoms in Magneto-Optical Traps (MOTs) using high-power, narrow-linewidth lasers. We report on the laser and optical master-slave injection locked system used to address the 1S0 - 3P1 strontium transition at 689 nm, and on the trapping of strontium atoms in a narrowband MOT. We demonstrate the quality of the injection through the characterisation of the injection lock using a novel, easy-to-assemble method which uses a double pass acousto-optic modulator (AOM) to generate and detect a heterodyne beatnote. The reported system is used to produce an atomic cloud at a temperature of 812 +/- 43 nK in a narrowband red MOT.
Published: 2023

21. Gaia Focused Product Release: Sources from Service Interface Function image analysis -- Half a million new sources in omega Centauri

Author: Gaia Collaboration, Weingrill, K., Mints, A., Castañeda, J., Kostrzewa-Rutkowska, Z., Davidson, M., De Angeli, F., Hernández, J., Torra, F., Ramos-Lerate, M., Babusiaux, C., Biermann, M., Crowley, C., Evans, D. W., Lindegren, L., Martín-Fleitas, J. M., Palaversa, L., Mieres, D. Ruz, Tisanić, K., Brown, A. G. A., Vallenari, A., Prusti, T., de Bruijne, J. H. J., Arenou, F., Barbier, A., Creevey, O. L., Ducourant, C., Eyer, L., Guerra, R., Hutton, A., Jordi, C., Klioner, S. A., Lammers, U., Luri, X., Mignard, F., Randich, S., Sartoretti, P., Smiljanic, R., Tanga, P., Walton, N. A., Bailer-Jones, C. A. L., Bastian, U., Cropper, M., Drimmel, R., Katz, D., Soubiran, C., van Leeuwen, F., Audard, M., Bakker, J., Blomme, R., Fabricius, C., Fouesneau, M., Frémat, Y., Galluccio, L., Guerrier, A., Masana, E., Messineo, R., Nicolas, C., Nienartowicz, K., Pailler, F., Panuzzo, P., Riclet, F., Roux, W., Seabroke, G. M., Sordo, R., Thévenin, F., Gracia-Abril, G., Portell, J., Teyssier, D., Altmann, M., Benson, K., Berthier, J., Burgess, P. W., Busonero, D., Busso, G., Cánovas, H., Carry, B., Cheek, N., Clementini, G., Damerdji, Y., de Teodoro, P., Delchambre, L., DellÓro, A., Garcia, E. Fraile, Garabato, D., García-Lario, P., Torres, N. Garralda, Gavras, P., Haigron, R., Hambly, N. C., Harrison, D. L., Hatzidimitriou, D., Hodgkin, S. T., Holl, B., Jamal, S., Jordan, S., Krone-Martins, A., Lanzafame, A. C., Löffler, W., Lorca, A., Marchal, O., Marrese, P. M., Moitinho, A., Muinonen, K., Campos, M. Nuñez, Oreshina-Slezak, I., Osborne, P., Pancino, E., Pauwels, T., Recio-Blanco, A., Riello, M., Rimoldini, L., Robin, A. C., Roegiers, T., Sarro, L. M., Schultheis, M., Siopis, C., Smith, M., Sozzetti, A., Utrilla, E., van Leeuwen, M., Abbas, U., Ábrahám, P., Aramburu, A. Abreu, Aerts, C., Altavilla, G., Álvarez, M. A., Alves, J., Anders, F., Anderson, R. I., Antoja, T., Baines, D., Baker, S. G., Balog, Z., Barache, C., Barbato, D., Barros, M., Barstow, M. A., Bartolomé, S., Bashi, D., Bauchet, N., Baudeau, N., Becciani, U., Bedin, L. R., Bellas-Velidis, I., Bellazzini, M., Beordo, W., Berihuete, A., Bernet, M., Bertolotto, C., Bertone, S., Bianchi, L., Binnenfeld, A., Blazere, A., Boch, T., Bombrun, A., Bouquillon, S., Bragaglia, A., Braine, J., Bramante, L., Breedt, E., Bressan, A., Brouillet, N., Brugaletta, E., Bucciarelli, B., Butkevich, A. G., Buzzi, R., Caffau, E., Cancelliere, R., Cannizzo, S., Cantat-Gaudin, T., Carballo, R., Carlucci, T., Carnerero, M. I., Carrasco, J. M., Carretero, J., Carton, S., Casamiquela, L., Castellani, M., Castro-Ginard, A., Cesare, V., Charlot, P., Chemin, L., Chiaramida, V., Chiavassa, A., Chornay, N., Collins, R., Contursi, G., Cooper, W. J., Cornez, T., Crosta, M., Dafonte, C., de Laverny, P., De Luise, F., De March, R., de Souza, R., de Torres, A., del Peloso, E. F., Delbo, M., Delgado, A., Dharmawardena, T. E., Diakite, S., Diener, C., Distefano, E., Dolding, C., Dsilva, K., Durán, J., Enke, H., Esquej, P., Fabre, C., Fabrizio, M., Faigler, S., Fatović, M., Fedorets, G., Fernández-Hernández, J., Fernique, P., Figueras, F., Fournier, Y., Fouron, C., Gai, M., Galinier, M., Garcia-Gutierrez, A., García-Torres, M., Garofalo, A., Gerlach, E., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Gomel, R., Gomez, A., González-Núñez, J., González-Santamaría, I., Gosset, E., Granvik, M., Barrera, V. Gregori, Gutiérrez-Sánchez, R., Haywood, M., Helmer, A., Helmi, A., Henares, K., Hidalgo, S. L., Hilger, T., Hobbs, D., Hottier, C., Huckle, H. E., Jabłońska, M., Jansen, F., Jiménez-Arranz, Ó., Campillo, J. Juaristi, Khanna, S., Kordopatis, G., Kóspál, Á, Kun, M., Lambert, S., Lanza, A. F., Campion, J. -F. Le, Lebreton, Y., Lebzelter, T., Leccia, S., Lecoeur-Taibi, I., Lecoutre, G., Liao, S., Liberato, L., Licata, E., Lindstrøm, H. E. P., Lister, T. A., Livanou, E., Lobel, A., Loup, C., Mahy, L., Mann, R. G., Manteiga, M., Marchant, J. M., Marconi, M., Pina, D. Marín, Marinoni, S., Marshall, D. J., Lozano, J. Martín, Marton, G., Mary, N., Masip, A., Massari, D., Mastrobuono-Battisti, A., Mazeh, T., McMillan, P. J., Meichsner, J., Messina, S., Michalik, D., Millar, N. R., Molina, D., Molinaro, R., Molnár, L., Monari, G., Monguió, M., Montegriffo, P., Montero, A., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morris, D., Mowlavi, N., Munoz, D., Muraveva, T., Murphy, C. P., Musella, I., Nagy, Z., Nieto, S., Noval, L., Ogden, A., Ordenovic, C., Pagani, C., Pagano, I., Palicio, P. A., Pallas-Quintela, L., Panahi, A., Panem, C., Payne-Wardenaar, S., Pegoraro, L., Penttilä, A., Pesciullesi, P., Piersimoni, A. M., Pinamonti, M., Pineau, F. -X., Plachy, E., Plum, G., Poggio, E., Pourbaix, D., Prša, A., Pulone, L., Racero, E., Rainer, M., Raiteri, C. M., Ramos, P., Ratajczak, M., Fiorentin, P. Re, Regibo, S., Reylé, C., Ripepi, V., Riva, A., Rix, H. -W., Rixon, G., Robichon, N., Robin, C., Romero-Gómez, M., Rowell, N., Royer, F., Rybicki, K. A., Sadowski, G., Núñez, A. Sáez, Sellés, A. Sagristà, Sahlmann, J., Gimenez, V. Sanchez, Sanna, N., Santoveña, R., Sarasso, M., Riera, C. Sarrate, Sciacca, E., Segovia, J. C., Ségransan, D., Shahaf, S., Siebert, A., Siltala, L., Slezak, E., Smart, R. L., Snaith, O. N., Solano, E., Solitro, F., Souami, D., Souchay, J., Spina, L., Spitoni, E., Spoto, F., Squillante, L. A., Steele, I. A., Steidelmüller, H., Surdej, J., Szabados, L., Taris, F., Taylor, M. B., Teixeira, R., Tolomei, L., Elipe, G. Torralba, Trabucchi, M., Tsantaki, M., Ulla, A., Unger, N., Vanel, O., Vecchiato, A., Vicente, D., Voutsinas, S., Weiler, M., Wyrzykowski, Ł., Zhao, H., Zorec, J., Zwitter, T., Balaguer-Núñez, L., Leclerc, N., Morgenthaler, S., Robert, G., and Zucker, S.
Subjects: Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract: Gaia's readout window strategy is challenged by very dense fields in the sky. Therefore, in addition to standard Gaia observations, full Sky Mapper (SM) images were recorded for nine selected regions in the sky. A new software pipeline exploits these Service Interface Function (SIF) images of crowded fields (CFs), making use of the availability of the full two-dimensional (2D) information. This new pipeline produced half a million additional Gaia sources in the region of the omega Centauri ($\omega$ Cen) cluster, which are published with this Focused Product Release. We discuss the dedicated SIF CF data reduction pipeline, validate its data products, and introduce their Gaia archive table. Our aim is to improve the completeness of the {\it Gaia} source inventory in a very dense region in the sky, $\omega$ Cen. An adapted version of {\it Gaia}'s Source Detection and Image Parameter Determination software located sources in the 2D SIF CF images. We validated the results by comparing them to the public {\it Gaia} DR3 catalogue and external Hubble Space Telescope data. With this Focused Product Release, 526\,587 new sources have been added to the {\it Gaia} catalogue in $\omega$ Cen. Apart from positions and brightnesses, the additional catalogue contains parallaxes and proper motions, but no meaningful colour information. While SIF CF source parameters generally have a lower precision than nominal {\it Gaia} sources, in the cluster centre they increase the depth of the combined catalogue by three magnitudes and improve the source density by a factor of ten. This first SIF CF data publication already adds great value to the {\it Gaia} catalogue. It demonstrates what to expect for the fourth {\it Gaia} catalogue, which will contain additional sources for all nine SIF CF regions.
Published: 2023
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22. Gaia Focused Product Release: A catalogue of sources around quasars to search for strongly lensed quasars

Author: Gaia Collaboration, Krone-Martins, A., Ducourant, C., Galluccio, L., Delchambre, L., Oreshina-Slezak, I., Teixeira, R., Braine, J., Campion, J. -F. Le, Mignard, F., Roux, W., Blazere, A., Pegoraro, L., Brown, A. G. A., Vallenari, A., Prusti, T., de Bruijne, J. H. J., Arenou, F., Babusiaux, C., Barbier, A., Biermann, M., Creevey, O. L., Evans, D. W., Eyer, L., Guerra, R., Hutton, A., Jordi, C., Klioner, S. A., Lammers, U., Lindegren, L., Luri, X., Randich, S., Sartoretti, P., Smiljanic, R., Tanga, P., Walton, N. A., Bailer-Jones, C. A. L., Bastian, U., Cropper, M., Drimmel, R., Katz, D., Soubiran, C., van Leeuwen, F., Audard, M., Bakker, J., Blomme, R., Castaneda, J., De Angeli, F., Fabricius, C., Fouesneau, M., Fremat, Y., Guerrier, A., Masana, E., Messineo, R., Nicolas, C., Nienartowicz, K., Pailler, F., Panuzzo, P., Riclet, F., Seabroke, G. M., Sordo, R., Thevenin, F., Gracia-Abril, G., Portell, J., Teyssier, D., Altmann, M., Benson, K., Berthier, J., Burgess, P. W., Busonero, D., Busso, G., Canovas, H., Carry, B., Cheek, N., Clementini, G., Damerdji, Y., Davidson, M., de Teodoro, P., Dell'Oro, A., Garcia, E. Fraile, Garabato, D., Garcia-Lario, P., Torres, N. Garralda, Gavras, P., Haigron, R., Hambly, N. C., Harrison, D. L., Hatzidimitriou, D., Hernandez, J., Hodgkin, S. T., Holl, B., Jamal, S., Jordan, S., Lanzafame, A. C., Loffler, W., Lorca, A., Marchal, O., Marrese, P. M., Moitinho, A., Muinonen, K., Campos, M. Nunez, Osborne, P., Pancino, E., Pauwels, T., Recio-Blanco, A., Riello, M., Rimoldini, L., Robin, A. C., Roegiers, T., Sarro, L. M., Schultheis, M., Siopis, C., Smith, M., Sozzetti, A., Utrilla, E., van Leeuwen, M., Weingrill, K., Abbas, U., Abraham, P., Aramburu, A. Abreu, Aerts, C., Altavilla, G., Alvarez, M. A., Alves, J., Anderson, R. I., Antoja, T., Baines, D., Baker, S. G., Balog, Z., Barache, C., Barbato, D., Barros, M., Barstow, M. A., Bartolome, S., Bashi, D., Bauchet, N., Baudeau, N., Becciani, U., Bedin, L. R., Bellas-Velidis, I., Bellazzini, M., Beordo, W., Berihuete, A., Bernet, M., Bertolotto, C., Bertone, S., Bianchi, L., Binnenfeld, A., Boch, T., Bombrun, A., Bouquillon, S., Bragaglia, A., Bramante, L., Breedt, E., Bressan, A., Brouillet, N., Brugaletta, E., Bucciarelli, B., Butkevich, A. G., Buzzi, R., Caffau, E., Cancelliere, R., Cannizzo, S., Carballo, R., Carlucci, T., Carnerero, M. I., Carrasco, J. M., Carretero, J., Carton, S., Casamiquela, L., Castellani, M., Castro-Ginard, A., Cesare, V., Charlot, P., Chemin, L., Chiaramida, V., Chiavassa, A., Chornay, N., Collins, R., Contursi, G., Cooper, W. J., Cornez, T., Crosta, M., Crowley, C., Dafonte, C., de Laverny, P., De Luise, F., De March, R., de Souza, R., de Torres, A., del Peloso, E. F., Delbo, M., Delgado, A., Dharmawardena, T. E., Diakite, S., Diener, C., Distefano, E., Dolding, C., Dsilva, K., Duran, J., Enke, H., Esquej, P., Fabre, C., Fabrizio, M., Faigler, S., Fatovic, M., Fedorets, G., Fernandez-Hernandez, J., Fernique, P., Figueras, F., Fournier, Y., Fouron, C., Gai, M., Galinier, M., Garcia-Gutierrez, A., Garcia-Torres, M., Garofalo, A., Gerlach, E., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Gomel, R., Gomez, A., Gonzalez-Nunez, J., Gonzalez-Santamaria, I., Gosset, E., Granvik, M., Barrera, V. Gregori, Gutierrez-Sanchez, R., Haywood, M., Helmer, A., Helmi, A., Henares, K., Hidalgo, S. L., Hilger, T., Hobbs, D., Hottier, C., Huckle, H. E., Jablonska, M., Jansen, F., Jimenez-Arranz, O., Campillo, J. Juaristi, Khanna, S., Kordopatis, G., Kospal, A., Kostrzewa-Rutkowska, Z., Kun, M., Lambert, S., Lanza, A. F., Lebreton, Y., Lebzelter, T., Leccia, S., Lecoeur-Taibi, I., Lecoutre, G., Liao, S., Liberato, L., Licata, E., Lindstrom, H. E. P., Lister, T. A., Livanou, E., Lobel, A., Loup, C., Mahy, L., Mann, R. G., Manteiga, M., Marchant, J. M., Marconi, M., Pina, D. Marin, Marinoni, S., Marshall, D. J., Lozano, J. Martin, Martin-Fleitas, J. M., Marton, G., Mary, N., Masip, A., Massari, D., Mastrobuono-Battisti, A., Mazeh, T., McMillan, P. J., Meichsner, J., Messina, S., Michalik, D., Millar, N. R., Mints, A., Molina, D., Molinaro, R., Molnar, L., Monari, G., Monguio, M., Montegriffo, P., Montero, A., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morris, D., Mowlavi, N., Munoz, D., Muraveva, T., Murphy, C. P., Musella, I., Nagy, Z., Nieto, S., Noval, L., Ogden, A., Ordenovic, C., Pagani, C., Pagano, I., Palaversa, L., Palicio, P. A., Pallas-Quintela, L., Panahi, A., Panem, C., Payne-Wardenaar, S., Penttila, A., Pesciullesi, P., Piersimoni, A. M., Pinamonti, M., Pineau, F. -X., Plachy, E., Plum, G., Poggio, E., Pourbaix, D., Prsa, A., Pulone, L., Racero, E., Rainer, M., Raiteri, C. M., Ramos, P., Ramos-Lerate, M., Ratajczak, M., Fiorentin, P. Re, Regibo, S., Reyle, C., Ripepi, V., Riva, A., Rix, H. -W., Rixon, G., Robichon, N., Robin, C., Romero-Gomez, M., Rowell, N., Royer, F., Mieres, D. Ruz, Rybicki, K. A., Sadowski, G., Nunez, A. Saez, Selles, A. Sagrista, Sahlmann, J., Gimenez, V. Sanchez, Sanna, N., Santovena, R., Sarasso, M., Riera, C. Sarrate, Sciacca, E., Segovia, J. C., Segransan, D., Shahaf, S., Siebert, A., Siltala, L., Slezak, E., Smart, R. L., Snaith, O. N., Solano, E., Solitro, F., Souami, D., Souchay, J., Spina, L., Spitoni, E., Spoto, F., Squillante, L. A., Steele, I. A., Steidelmuller, H., Surdej, J., Szabados, L., Taris, F., Taylor, M. B., Tisanic, K., Tolomei, L., Torra, F., Elipe, G. Torralba, Trabucchi, M., Tsantaki, M., Ulla, A., Unger, N., Vanel, O., Vecchiato, A., Vicente, D., Voutsinas, S., Weiler, M., Wyrzykowski, L., Zhao, H., Zorec, J., Zwitter, T., Balaguer-Nunez, L., Leclerc, N., Morgenthaler, S., Robert, G., and Zucker, S.
Subjects: Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: Context. Strongly lensed quasars are fundamental sources for cosmology. The Gaia space mission covers the entire sky with the unprecedented resolution of $0.18$" in the optical, making it an ideal instrument to search for gravitational lenses down to the limiting magnitude of 21. Nevertheless, the previous Gaia Data Releases are known to be incomplete for small angular separations such as those expected for most lenses. Aims. We present the Data Processing and Analysis Consortium GravLens pipeline, which was built to analyse all Gaia detections around quasars and to cluster them into sources, thus producing a catalogue of secondary sources around each quasar. We analysed the resulting catalogue to produce scores that indicate source configurations that are compatible with strongly lensed quasars. Methods. GravLens uses the DBSCAN unsupervised clustering algorithm to detect sources around quasars. The resulting catalogue of multiplets is then analysed with several methods to identify potential gravitational lenses. We developed and applied an outlier scoring method, a comparison between the average BP and RP spectra of the components, and we also used an extremely randomised tree algorithm. These methods produce scores to identify the most probable configurations and to establish a list of lens candidates. Results. We analysed the environment of 3 760 032 quasars. A total of 4 760 920 sources, including the quasars, were found within 6" of the quasar positions. This list is given in the Gaia archive. In 87\% of cases, the quasar remains a single source, and in 501 385 cases neighbouring sources were detected. We propose a list of 381 lensed candidates, of which we identified 49 as the most promising. Beyond these candidates, the associate tables in this Focused Product Release allow the entire community to explore the unique Gaia data for strong lensing studies further., Comment: 35 pages, 60 figures, accepted for publication by Astronomy and Astrophysics
Published: 2023
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23. Gaia Focused Product Release: Radial velocity time series of long-period variables

Author: Gaia Collaboration, Trabucchi, M., Mowlavi, N., Lebzelter, T., Lecoeur-Taibi, I., Audard, M., Eyer, L., García-Lario, P., Gavras, P., Holl, B., de Fombelle, G. Jevardat, Nienartowicz, K., Rimoldini, L., Sartoretti, P., Blomme, R., Frémat, Y., Marchal, O., Damerdji, Y., Brown, A. G. A., Guerrier, A., Panuzzo, P., Katz, D., Seabroke, G. M., Benson, K., Haigron, R., Smith, M., Lobel, A., Vallenari, A., Prusti, T., de Bruijne, J. H. J., Arenou, F., Babusiaux, C., Barbier, A., Biermann, M., Creevey, O. L., Ducourant, C., Evans, D. W., Guerra, R., Hutton, A., Jordi, C., Klioner, S. A., Lammers, U., Lindegren, L., Luri, X., Mignard, F., Randich, S., Smiljanic, R., Tanga, P., Walton, N. A., Bailer-Jones, C. A. L., Bastian, U., Cropper, M., Drimmel, R., Lattanzi, M. G., Soubiran, C., van Leeuwen, F., Bakker, J., Castañeda, J., De Angeli, F., Fabricius, C., Fouesneau, M., Galluccio, L., Masana, E., Messineo, R., Nicolas, C., Pailler, F., Riclet, F., Roux, W., Sordo, R., Thévenin, F., Gracia-Abril, G., Portell, J., Teyssier, D., Altmann, M., Berthier, J., Burgess, P. W., Busonero, D., Busso, G., Cánovas, H., Carry, B., Cheek, N., Clementini, G., Davidson, M., de Teodoro, P., Delchambre, L., Dell'Oro, A., Garcia, E. Fraile, Garabato, D., Torres, N. Garralda, Hambly, N. C., Harrison, D. L., Hatzidimitriou, D., Hernández, J., Hodgkin, S. T., Jamal, S., Jordan, S., Krone-Martins, A., Lanzafame, A. C., Löffler, W., Lorca, A., Marrese, P. M., Moitinho, A., Muinonen, K., Campos, M. Nuñez, Oreshina-Slezak, I., Osborne, P., Pancino, E., Pauwels, T., Recio-Blanco, A., Riello, M., Robin, A. C., Roegiers, T., Sarro, L. M., Schultheis, M., Siopis, C., Sozzetti, A., Utrilla, E., van Leeuwen, M., Weingrill, K., Abbas, U., Ábrahám, P., Aramburu, A. Abreu, Aerts, C., Altavilla, G., Álvarez, M. A., Alves, J., Anders, F., Anderson, R. I., Antoja, T., Baines, D., Baker, S. G., Balog, Z., Barache, C., Barbato, D., Barros, M., Barstow, M. A., Bartolomé, S., Bashi, D., Bauchet, N., Baudeau, N., Becciani, U., Bedin, L. R., Bellas-Velidis, I., Bellazzini, M., Beordo, W., Berihuete, A., Bernet, M., Bertolotto, C., Bertone, S., Bianchi, L., Binnenfeld, A., Blazere, A., Boch, T., Bombrun, A., Bouquillon, S., Bragaglia, A., Braine, J., Bramante, L., Breedt, E., Bressan, A., Brouillet, N., Brugaletta, E., Bucciarelli, B., Butkevich, A. G., Buzzi, R., Caffau, E., Cancelliere, R., Cannizzo, S., Carballo, R., Carlucci, T., Carnerero, M. I., Carrasco, J. M., Carretero, J., Carton, S., Casamiquela, L., Castellani, M., Castro-Ginard, A., Cesare, V., Charlot, P., Chemin, L., Chiaramida, V., Chiavassa, A., Chornay, N., Collins, R., Contursi, G., Cooper, W. J., Cornez, T., Crosta, M., Crowley, C., Dafonte, C., David, M., de Laverny, P., De Luise, F., De March, R., De Ridder, J., de Souza, R., de Torres, A., del Peloso, E. F., Delbo, M., Delgado, A., Dharmawardena, T. E., Diakite, S., Diener, C., Distefano, E., Dolding, C., Dsilva, K., Durán, J., Enke, H., Esquej, P., Fabre, C., Fabrizio, M., Faigler, S., Fatović, M., Fedorets, G., Fernández-Hernández, J., Fernique, P., Figueras, F., Fournier, Y., Fouron, C., Gai, M., Galinier, M., Garcia-Gutierrez, A., García-Torres, M., Garofalo, A., Gerlach, E., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Gomel, R., Gomez, A., González-Núñez, J., González-Santamaría, I., Gosset, E., Granvik, M., Barrera, V. Gregori, Gutiérrez-Sánchez, R., Haywood, M., Helmer, A., Helmi, A., Henares, K., Hidalgo, S. L., Hilger, T., Hobbs, D., Hottier, C., Huckle, H. E., Jabłońska, M., Jansen, F., Jiménez-Arranz, Ó., Campillo, J. Juaristi, Khanna, S., Kordopatis, G., Kóspál, Á, Kostrzewa-Rutkowska, Z., Kun, M., Lambert, S., Lanza, A. F., Campion, J. -F. Le, Lebreton, Y., Leccia, S., Lecoutre, G., Liao, S., Liberato, L., Licata, E., Lindstrøm, H. E. P., Lister, T. A., Livanou, E., Loup, C., Mahy, L., Mann, R. G., Manteiga, M., Marchant, J. M., Marconi, M., Pina, D. Marín, Marinoni, S., Marshall, D. J., Lozano, J. Martín, Martín-Fleitas, J. M., Marton, G., Mary, N., Masip, A., Massari, D., Mastrobuono-Battisti, A., Mazeh, T., McMillan, P. J., Meichsner, J., Messina, S., Michalik, D., Millar, N. R., Mints, A., Molina, D., Molinaro, R., Molnár, L., Monari, G., Monguió, M., Montegriffo, P., Montero, A., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morris, D., Munoz, D., Muraveva, T., Murphy, C. P., Musella, I., Nagy, Z., Nieto, S., Noval, L., Ogden, A., Ordenovic, C., Pagani, C., Pagano, I., Palaversa, L., Palicio, P. A., Pallas-Quintela, L., Panahi, A., Panem, C., Payne-Wardenaar, S., Pegoraro, L., Penttilä, A., Pesciullesi, P., Piersimoni, A. M., Pinamonti, M., Pineau, F. -X., Plachy, E., Plum, G., Poggio, E., Pourbaix, D., Prša, A., Pulone, L., Racero, E., Rainer, M., Raiteri, C. M., Ramos, P., Ramos-Lerate, M., Ratajczak, M., Fiorentin, P. Re, Regibo, S., Reylé, C., Ripepi, V., Riva, A., Rix, H. -W., Rixon, G., Robichon, N., Robin, C., Romero-Gómez, M., Rowell, N., Royer, F., Mieres, D. Ruz, Rybicki, K. A., Sadowski, G., Núñez, A. Sáez, Sellés, A. Sagristà, Sahlmann, J., Gimenez, V. Sanchez, Sanna, N., Santoveña, R., Sarasso, M., Riera, C. Sarrate, Sciacca, E., Segovia, J. C., Ségransan, D., Shahaf, S., Siebert, A., Siltala, L., Slezak, E., Smart, R. L., Snaith, O. N., Solano, E., Solitro, F., Souami, D., Souchay, J., Spina, L., Spitoni, E., Spoto, F., Squillante, L. A., Steele, I. A., Steidelmüller, H., Surdej, J., Szabados, L., Taris, F., Taylor, M. B., Teixeira, R., Tisanić, K., Tolomei, L., Torra, F., Elipe, G. Torralba, Tsantaki, M., Ulla, A., Unger, N., Vanel, O., Vecchiato, A., Vicente, D., Voutsinas, S., Weiler, M., Wyrzykowski, Ł., Zhao, H., Zorec, J., Zwitter, T., Balaguer-Núñez, L., Leclerc, N., Morgenthaler, S., Robert, G., and Zucker, S.
Subjects: Astrophysics - Solar and Stellar Astrophysics
Abstract: The third Gaia Data Release (DR3) provided photometric time series of more than 2 million long-period variable (LPV) candidates. Anticipating the publication of full radial-velocity (RV) in DR4, this Focused Product Release (FPR) provides RV time series for a selection of LPVs with high-quality observations. We describe the production and content of the Gaia catalog of LPV RV time series, and the methods used to compute variability parameters published in the Gaia FPR. Starting from the DR3 LPVs catalog, we applied filters to construct a sample of sources with high-quality RV measurements. We modeled their RV and photometric time series to derive their periods and amplitudes, and further refined the sample by requiring compatibility between the RV period and at least one of the $G$, $G_{\rm BP}$, or $G_{\rm RP}$ photometric periods. The catalog includes RV time series and variability parameters for 9\,614 sources in the magnitude range $6\lesssim G/{\rm mag}\lesssim 14$, including a flagged top-quality subsample of 6\,093 stars whose RV periods are fully compatible with the values derived from the $G$, $G_{\rm BP}$, and $G_{\rm RP}$ photometric time series. The RV time series contain a mean of 24 measurements per source taken unevenly over a duration of about three years. We identify the great most sources (88%) as genuine LPVs, with about half of them showing a pulsation period and the other half displaying a long secondary period. The remaining 12% consists of candidate ellipsoidal binaries. Quality checks against RVs available in the literature show excellent agreement. We provide illustrative examples and cautionary remarks. The publication of RV time series for almost 10\,000 LPVs constitutes, by far, the largest such database available to date in the literature. The availability of simultaneous photometric measurements gives a unique added value to the Gaia catalog (abridged), Comment: 36 pages, 38 figures
Published: 2023

24. Gaia data processing. SEAPipe: The source environment analysis pipeline

Author: Harrison, D. L., van Leeuwen, F., Osborne, P. J., Burgess, P. W., De Angeli, F., and Evans, D. W.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: Aims. To describe two potential options for the Source Environment Analysis pipeline, SEAPipe, for the Gaia mission. This pipeline will enable the discovery of sources which are new to Gaia, in the sense that they were not found by the on-board detection algorithm. These additional sources (secondaries) are discoverable in the vicinity of those Gaia sources (primaries) that were found by the on-board detection. Methods. The main algorithmic steps required are described; the 2-dimensional image reconstruction of 1-dimensional transit data, the analysis of these images to find the additional sources present, and the determination of the mean positions, proper motions, parallaxes and brightness of these sources. Additionally, the Monte Carlo simulations used to characterise the performance of the pipelines are described. Results. The performance of the two options for SEAPipe, the vanilla and image-subtraction versions, are compared. Their selection functions are computed in terms of the magnitude of the secondary sources and their angular separations from their corresponding primary source. The completeness and purity of the resultant catalogue of secondary sources as found by each of the pipelines, given the expected magnitude distribution of the primary sources and the magnitude and angular separation distributions of the secondary sources, is also presented. The image-subtraction pipeline is shown to out-perform the vanilla pipeline., Comment: 13 pages, 14 figures. Accepted by A&A
Published: 2023
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25. Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated “Big Bang” pathway to CRC in three of the four Lynch syndromes

Author: Møller, Pål, Haupt, Saskia, Ahadova, Aysel, Kloor, Matthias, Sampson, Julian R., Sunde, Lone, Seppälä, Toni, Burn, John, Bernstein, Inge, Capella, Gabriel, Evans, D. Gareth, Lindblom, Annika, Winship, Ingrid, Macrae, Finlay, Katz, Lior, Laish, Ido, Vainer, Elez, Monahan, Kevin, Half, Elizabeth, Horisberger, Karoline, da Silva, Leandro Apolinário, Heuveline, Vincent, Therkildsen, Christina, Lautrup, Charlotte, Klarskov, Louise L, Cavestro, Giulia Martina, Möslein, Gabriela, Hovig, Eivind, and Dominguez-Valentin, Mev
Published: 2024
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26. Venous thromboembolism chemical prophylaxis after skull base surgery

Author: Waqar, Mueez, Yaseen, Omar, Chadwick, Annabel, Lee, Jing Xian, Khan, Ghazn, Evans, D. Gareth, Horner, Daniel, Jaiswal, Archana, Freeman, Simon, Bhalla, Rajiv, Lloyd, Simon, Hammerbeck-Ward, Charlotte, Rutherford, Scott A., King, Andrew T., and Pathmanaban, Omar N.
Published: 2024
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27. Penetrance estimates of hereditary cancers in a population setting using UK Biobank data

Author: Manchanda, Ranjit, Evans, D. Gareth, Antoniou, Antonis C., and Brentnall, Adam
Published: 2024
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28. Weight, weight gain and behavioural risk factors in women attending a breast cancer family history, risk and prevention clinic: an observational study

Author: Pegington, Mary, Belcher, John, Barrett, Emma, Virpal, Pawandeep, Howell, Anthony, Evans, D. Gareth, and Harvie, Michelle
Published: 2024
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29. Cancer Precision-Prevention trial of Metformin in adults with Li Fraumeni syndrome (MILI) undergoing yearly MRI surveillance: a randomised controlled trial protocol

Author: Dixon-Zegeye, Miriam, Shaw, Rachel, Collins, Linda, Perez-Smith, Kendra, Ooms, Alexander, Qiao, Maggie, Pantziarka, Pan, Izatt, Louise, Tischkowitz, Marc, Harrison, Rachel E., George, Angela, Woodward, Emma R., Lord, Simon, Hawkes, Lara, Evans, D. Gareth, Franklin, James, Hanson, Helen, and Blagden, Sarah P.
Published: 2024
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30. Multiplicity dependence of charged-particle intra-jet properties in pp collisions at s = 13 TeV

Author: Acharya, S., Adamová, D., Rinella, G. Aglieri, Aglietta, L., Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S. U., Ahuja, I., Akindinov, A., Al-Turany, M., Aleksandrov, D., Alessandro, B., Alfanda, H. M., Molina, R. Alfaro, Ali, B., Alici, A., Alizadehvandchali, N., Alkin, A., Alme, J., Alocco, G., Alt, T., Altamura, A. R., Altsybeev, I., Alvarado, J. R., Anaam, M. N., Andrei, C., Andreou, N., Andronic, A., Andronov, E., Anguelov, V., Antinori, F., Antonioli, P., Apadula, N., Aphecetche, L., Appelshäuser, H., Arata, C., Arcelli, S., Aresti, M., Arnaldi, R., Arneiro, J. G. M. C. A., Arsene, I. C., Arslandok, M., Augustinus, A., Averbeck, R., Azmi, M. D., Baba, H., Badalà, A., Bae, J., Baek, Y. W., Bai, X., Bailhache, R., Bailung, Y., Bala, R., Balbino, A., Baldisseri, A., Balis, B., Banerjee, D., Banoo, Z., Barile, F., Barioglio, L., Barlou, M., Barman, B., Barnaföldi, G. G., Barnby, L. S., Barreau, E., Barret, V., Barreto, L., Bartels, C., Barth, K., Bartsch, E., Bastid, N., Basu, S., Batigne, G., Battistini, D., Batyunya, B., Bauri, D., Alba, J. L. Bazo, Bearden, I. G., Beattie, C., Becht, P., Behera, D., Belikov, I., Bell Hechavarria, A. D. C., Bellini, F., Bellwied, R., Belokurova, S., Beltran, L. G. E., Beltran, Y. A. V., Bencedi, G., Beole, S., Berdnikov, Y., Berdnikova, A., Bergmann, L., Besoiu, M. G., Betev, L., Bhaduri, P. P., Bhasin, A., Bhat, M. A., Bhattacharjee, B., Bianchi, L., Bianchi, N., Bielčík, J., Bielčíková, J., Bigot, A. P., Bilandzic, A., Biro, G., Biswas, S., Bize, N., Blair, J. T., Blau, D., Blidaru, M. B., Bluhme, N., Blume, C., Boca, G., Bock, F., Bodova, T., Boi, S., Bok, J., Boldizsár, L., Bombara, M., Bond, P. M., Bonomi, G., Borel, H., Borissov, A., Borquez Carcamo, A. G., Bossi, H., Botta, E., Bouziani, Y. E. M., Bratrud, L., Braun-Munzinger, P., Bregant, M., Broz, M., Bruno, G. E., Buckland, M. D., Budnikov, D., Buesching, H., Bufalino, S., Buhler, P., Burmasov, N., Buthelezi, Z., Bylinkin, A., Bysiak, S. A., Cabanillas Noris, J. C., Cai, M., Caines, H., Caliva, A., Calvo Villar, E., Camacho, J. M. M., Camerini, P., Canedo, F. D. M., Cantway, S. L., Carabas, M., Carballo, A. A., Carnesecchi, F., Caron, R., Carvalho, L. A. D., Castillo Castellanos, J., Catalano, F., Cattaruzzi, S., Ceballos Sanchez, C., Cerri, R., Chakaberia, I., Chakraborty, P., Chandra, S., Chapeland, S., Chartier, M., Chattopadhyay, S., Chattopadhyay, S., Cheng, T., Cheshkov, C., Chibante Barroso, V., Chinellato, D. D., Chizzali, E. S., Cho, J., Cho, S., Chochula, P., Choudhury, D., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Ciacco, M., Cicalo, C., Ciupek, M. R., Clai, G., Colamaria, F., Colburn, J. S., Colella, D., Colocci, M., Concas, M., Conesa Balbastre, G., Conesa del Valle, Z., Contin, G., Contreras, J. G., Coquet, M. L., Cortese, P., Cosentino, M. R., Costa, F., Costanza, S., Cot, C., Crkovská, J., Crochet, P., Cruz-Torres, R., Cui, P., Dainese, A., Danisch, M. C., Danu, A., Das, P., Das, P., Das, S., Dash, A. R., Dash, S., De Caro, A., de Cataldo, G., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Martin, C., De Pasquale, S., Deb, R., Del Grande, R., Stritto, L. Dello, Deng, W., Dhankher, P., Di Bari, D., Di Mauro, A., Diab, B., Diaz, R. A., Dietel, T., Ding, Y., Ditzel, J., Divià, R., Dixit, D. U., Djuvsland, Ø., Dmitrieva, U., Dobrin, A., Dönigus, B., Dubinski, J. M., Dubla, A., Dudi, S., Dupieux, P., Durkac, M., Dzalaiova, N., Eder, T. M., Ehlers, R. J., Eisenhut, F., Ejima, R., Elia, D., Erazmus, B., Ercolessi, F., Espagnon, B., Eulisse, G., Evans, D., Evdokimov, S., Fabbietti, L., Faggin, M., Faivre, J., Fan, F., Fan, W., Fantoni, A., Fasel, M., Feliciello, A., Feofilov, G., Fernández Téllez, A., Ferrandi, L., Ferrer, M. B., Ferrero, A., Ferrero, C., Ferretti, A., Feuillard, V. J. G., Filova, V., Finogeev, D., Fionda, F. M., Flatland, E., Flor, F., Flores, A. N., Foertsch, S., Fokin, I., Fokin, S., Fragiacomo, E., Frajna, E., Fuchs, U., Funicello, N., Furget, C., Furs, A., Fusayasu, T., Gaardhøje, J. J., Gagliardi, M., Gago, A. M., Gahlaut, T., Galvan, C. D., Gangadharan, D. R., Ganoti, P., Garabatos, C., García Chávez, T., Garcia-Solis, E., Gargiulo, C., Gasik, P., Gautam, A., Gay Ducati, M. B., Germain, M., Ghimouz, A., Ghosh, C., Giacalone, M., Gioachin, G., Giubellino, P., Giubilato, P., Glaenzer, A. M. C., Glässel, P., Glimos, E., Goh, D. J. Q., Gonzalez, V., Gordeev, P., Gorgon, M., Goswami, K., Gotovac, S., Grabski, V., Graczykowski, L. K., Grecka, E., Grelli, A., Grigoras, C., Grigoriev, V., Grigoryan, S., Grosa, F., Grosse-Oetringhaus, J. F., Grosso, R., Grund, D., Grunwald, N. A., Guardiano, G. G., Guernane, R., Guilbaud, M., Gulbrandsen, K., Gündem, T., Gunji, T., Guo, W., Gupta, A., Gupta, R., Gupta, R., Gwizdziel, K., Gyulai, L., Hadjidakis, C., Haider, F. U., Haidlova, S., Haldar, M., Hamagaki, H., Hamdi, A., Han, Y., Hanley, B. G., Hannigan, R., Hansen, J., Harris, J. W., Harton, A., Hartung, M. V., Hassan, H., Hatzifotiadou, D., Hauer, P., Havener, L. B., Hellbär, E., Helstrup, H., Hemmer, M., Herman, T., Herrera Corral, G., Herrmann, F., Herrmann, S., Hetland, K. F., Heybeck, B., Hillemanns, H., Hippolyte, B., Hoffmann, F. W., Hofman, B., Hong, G. H., Horst, M., Horzyk, A., Hou, Y., Hristov, P., Huhn, P., Huhta, L. M., Humanic, T. J., Hutson, A., Hutter, D., Hwang, M. C., Ilkaev, R., Ilyas, H., Inaba, M., Innocenti, G. M., Ippolitov, M., Isakov, A., Isidori, T., Islam, M. S., Ivanov, M., Ivanov, M., Ivanov, V., Iversen, K. E., Jablonski, M., Jacak, B., Jacazio, N., Jacobs, P. M., Jadlovska, S., Jadlovsky, J., Jaelani, S., Jahnke, C., Jakubowska, M. J., Janik, M. A., Janson, T., Ji, S., Jia, S., Jimenez, A. A. P., Jonas, F., Jones, D. M., Jowett , J. M., Jung, J., Jung, M., Junique, A., Jusko, A., Kaewjai, J., Kalinak, P., Kalteyer, A. S., Kalweit, A., Karasu Uysal, A., Karatovic, D., Karavichev, O., Karavicheva, T., Karczmarczyk, P., Karpechev, E., Karwowska, M. J., Kebschull, U., Keidel, R., Keijdener, D. L. D., Keil, M., Ketzer, B., Khade, S. S., Khan, A. M., Khan, S., Khanzadeev, A., Kharlov, Y., Khatun, A., Khuntia, A., Khuranova, Z., Kileng, B., Kim, B., Kim, C., Kim, D. J., Kim, E. J., Kim, J., Kim, J., Kim, J., Kim, M., Kim, S., Kim, T., Kimura, K., Kirsch, S., Kisel, I., Kiselev, S., Kisiel, A., Kitowski, J. P., Klay, J. L., Klein, J., Klein, S., Klein-Bösing, C., Kleiner, M., Klemenz, T., Kluge, A., Kobdaj, C., Kollegger, T., Kondratyev, A., Kondratyeva, N., Konig, J., Konigstorfer, S. A., Konopka, P. J., Kornakov, G., Korwieser, M., Koryciak, S. D., Kotliarov, A., Kovacic, N., Kovalenko, V., Kowalski, M., Kozhuharov, V., Králik, I., Kravčáková, A., Krcal, L., Krivda, M., Krizek, F., Gajdosova, K. Krizkova, Kroesen, M., Krüger, M., Krupova, D. M., Kryshen, E., Kučera, V., Kuhn, C., Kuijer, P. G., Kumaoka, T., Kumar, D., Kumar, L., Kumar, N., Kumar, S., Kundu, S., Kurashvili, P., Kurepin, A., Kurepin, A. B., Kuryakin, A., Kushpil, S., Kuskov, V., Kutyla, M., Kweon, M. J., Kwon, Y., La Pointe, S. L., La Rocca, P., Lakrathok, A., Lamanna, M., Landou, A. R., Langoy, R., Larionov, P., Laudi, E., Lautner, L., Lavicka, R., Lea, R., Lee, H., Legrand, I., Legras, G., Lehrbach, J., Lelek, T. M., Lemmon, R. C., León Monzón, I., Lesch, M. M., Lesser, E. D., Lévai, P., Li, X., Liang-gilman, B. E., Lien, J., Lietava, R., Likmeta, I., Lim, B., Lim, S. H., Lindenstruth, V., Lindner, A., Lippmann, C., Liu, D. H., Liu, J., Liveraro, G. S. S., Lofnes, I. M., Loizides, C., Lokos, S., Lömker, J., Loncar, P., Lopez, X., López Torres, E., Lu, P., Lugo, F. V., Luhder, J. R., Lunardon, M., Luparello, G., Ma, Y. G., Mager, M., Maire, A., Majerz, E. M., Makariev, M. V., Malaev, M., Malfattore, G., Malik, N. M., Malik, Q. W., Malik, S. K., Malinina, L., Mallick, D., Mallick, N., Mandaglio, G., Mandal, S. K., Manko, V., Manso, F., Manzari, V., Mao, Y., Marcjan, R. W., Margagliotti, G. V., Margotti, A., Marín, A., Markert, C., Martinengo, P., Martínez, M. I., Martínez García, G., Martins, M. P. P., Masciocchi, S., Masera, M., Masoni, A., Massacrier, L., Massen, O., Mastroserio, A., Matonoha, O., Mattiazzo, S., Matyja, A., Mayer, C., Mazuecos, A. L., Mazzaschi, F., Mazzilli, M., Mdhluli, J. E., Melikyan, Y., Menchaca-Rocha, A., Mendez, J. E. M., Meninno, E., Menon, A. S., Meres, M., Miake, Y., Micheletti, L., Mihaylov, D. L., Mikhaylov, K., Miśkowiec, D., Modak, A., Mohanty, B., Khan, M. Mohisin, Molander, M. A., Monira, S., Mordasini, C., De Godoy, D. A. Moreira, Morozov, I., Morsch, A., Mrnjavac, T., Muccifora, V., Muhuri, S., Mulligan, J. D., Mulliri, A., Munhoz, M. G., Munzer, R. H., Murakami, H., Murray, S., Musa, L., Musinsky, J., Myrcha, J. W., Naik, B., Nambrath, A. I., Nandi, B. K., Nania, R., Nappi, E., Nassirpour, A. F., Nath, A., Nattrass, C., Naydenov, M. N., Neagu, A., Negru, A., Nekrasova, E., Nellen, L., Nepeivoda, R., Nese, S., Neskovic, G., Nicassio, N., Nielsen, B. S., Nielsen, E. G., Nikolaev, S., Nikulin, S., Nikulin, V., Noferini, F., Noh, S., Nomokonov, P., Norman, J., Novitzky, N., Nowakowski, P., Nyanin, A., Nystrand, J., Oh, S., Ohlson, A., Okorokov, V. A., Oleniacz, J., Onnerstad, A., Oppedisano, C., Ortiz Velasquez, A., Otwinowski, J., Oya, M., Oyama, K., Pachmayer, Y., Padhan, S., Pagano, D., Paić, G., Paisano-Guzmán, S., Palasciano, A., Panebianco, S., Park, H., Park, H., Park, J., Parkkila, J. E., Patley, Y., Paul, B., Paulino, M. M. D. M., Pei, H., Peitzmann, T., Peng, X., Pennisi, M., Perciballi, S., Peresunko, D., Perez, G. M., Pestov, Y., Petrov, V., Petrovici, M., Pezzi, R. P., Piano, S., Pikna, M., Pillot, P., Pinazza, O., Pinsky, L., Pinto, C., Pisano, S., Płoskoń, M., Planinic, M., Pliquett, F., Poghosyan, M. G., Polichtchouk, B., Politano, S., Poljak, N., Pop, A., Porteboeuf-Houssais, S., Pozdniakov, V., Pozos, I. Y., Pradhan, K. K., Prasad, S. K., Prasad, S., Preghenella, R., Prino, F., Pruneau, C. A., Pshenichnov, I., Puccio, M., Pucillo, S., Pugelova, Z., Qiu, S., Quaglia, L., Ragoni, S., Rai, A., Rakotozafindrabe, A., Ramello, L., Rami, F., Rancien, T. A., Rasa, M., Räsänen, S. S., Rath, R., Rauch, M. P., Ravasenga, I., Read, K. F., Reckziegel, C., Redelbach, A. R., Redlich, K., Reetz, C. A., Regules-Medel, H. D., Rehman, A., Reidt, F., Reme-Ness, H. A., Rescakova, Z., Reygers, K., Riabov, A., Riabov, V., Ricci, R., Richter, M., Riedel, A. A., Riegler, W., Riffero, A. G., Ristea, C., Rodriguez, M. V., Rodríguez Cahuantzi, M., Rodríguez Ramírez, S. A., Røed, K., Rogalev, R., Rogochaya, E., Rogoschinski, T. S., Rohr, D., Röhrich, D., Rojas, P. F., Rojas Torres, S., Rokita, P. S., Romanenko, G., Ronchetti, F., Rosano, A., Rosas, E. D., Roslon, K., Rossi, A., Roy, A., Roy, S., Rubini, N., Ruggiano, D., Rui, R., Russek, P. G., Russo, R., Rustamov, A., Ryabinkin, E., Ryabov, Y., Rybicki, A., Rytkonen, H., Ryu, J., Rzesa, W., Saarimaki, O. A. M., Sadhu, S., Sadovsky, S., Saetre, J., Šafařík, K., Saha, P., Saha, S. K., Saha, S., Sahoo, B., Sahoo, R., Sahoo, S., Sahu, D., Sahu, P. K., Saini, J., Sajdakova, K., Sakai, S., Salvan, M. P., Sambyal, S., Samitz, D., Sanna, I., Saramela, T. B., Sarkar, D., Sarma, P., Sarritzu, V., Sarti, V. M., Sas, M. H. P., Sawan, S., Scapparone, E., Schambach, J., Scheid, H. S., Schiaua, C., Schicker, R., Schlepper, F., Schmah, A., Schmidt, C., Schmidt, H. R., Schmidt, M. O., Schmidt, M., Schmidt, N. V., Schmier, A. R., Schotter, R., Schröter, A., Schukraft, J., Schweda, K., Scioli, G., Scomparin, E., Seger, J. E., Sekiguchi, Y., Sekihata, D., Selina, M., Selyuzhenkov, I., Senyukov, S., Seo, J. J., Serebryakov, D., Serkin, L., Šerkšnytė, L., Sevcenco, A., Shaba, T. J., Shabetai, A., Shahoyan, R., Shangaraev, A., Sharma, B., Sharma, D., Sharma, H., Sharma, M., Sharma, S., Sharma, S., Sharma, U., Shatat, A., Sheibani, O., Shigaki, K., Shimomura, M., Shin, J., Shirinkin, S., Shou, Q., Sibiriak, Y., Siddhanta, S., Siemiarczuk, T., Silva, T. F., Silvermyr, D., Simantathammakul, T., Simeonov, R., Singh, B., Singh, B., Singh, K., Singh, R., Singh, R., Singh, R., Singh, S., Singh, V. K., Singhal, V., Sinha, T., Sitar, B., Sitta, M., Skaali, T. B., Skorodumovs, G., Slupecki, M., Smirnov, N., Snellings, R. J. M., Solheim, E. H., Song, J., Sonnabend, C., Sonneveld, J. M., Soramel, F., Soto-hernandez, A. B., Spijkers, R., Sputowska, I., Staa, J., Stachel, J., Stan, I., Steffanic, P. J., Stiefelmaier, S. F., Stocco, D., Storehaug, I., Stratmann, P., Strazzi, S., Sturniolo, A., Stylianidis, C. P., Suaide, A. A. P., Suire, C., Sukhanov, M., Suljic, M., Sultanov, R., Sumberia, V., Sumowidagdo, S., Szarka, I., Szymkowski, M., Taghavi, S. F., Taillepied, G., Takahashi, J., Tambave, G. J., Tang, S., Tang, Z., Tapia Takaki, J. D., Tapus, N., Tarasovicova, L. A., Tarzila, M. G., Tassielli, G. F., Tauro, A., Tavira García, A., Tejeda Muñoz, G., Telesca, A., Terlizzi, L., Terrevoli, C., Thakur, S., Thomas, D., Tikhonov, A., Tiltmann, N., Timmins, A. R., Tkacik, M., Tkacik, T., Toia, A., Tokumoto, R., Tomohiro, K., Topilskaya, N., Toppi, M., Tork, T., Torres, V. V., Ramos, A. G. Torres, Trifiró, A., Triolo, A. S., Tripathy, S., Tripathy, T., Trogolo, S., Trubnikov, V., Trzaska, W. H., Trzcinski, T. P., Tumkin, A., Turrisi, R., Tveter, T. S., Ullaland, K., Ulukutlu, B., Uras, A., Urioni, M., Usai, G. L., Vala, M., Valle, N., van Doremalen, L. V. R., van Leeuwen, M., van Veen, C. A., van Weelden, R. J. G., Vande Vyvre, P., Varga, D., Varga, Z., Torres, P. Vargas, Vasileiou, M., Vasiliev, A., Vázquez Doce, O., Vazquez Rueda, O., Vechernin, V., Vercellin, E., Vergara Limón, S., Verma, R., Vermunt, L., Vértesi, R., Verweij, M., Vickovic, L., Vilakazi, Z., Villalobos Baillie, O., Villani, A., Vinogradov, A., Virgili, T., Virta, M. M. O., Vislavicius, V., Vodopyanov, A., Volkel, B., Völkl, M. A., Voloshin, S. A., Volpe, G., von Haller, B., Vorobyev, I., Vozniuk, N., Vrláková, J., Wan, J., Wang, C., Wang, D., Wang, Y., Wang, Y., Wegrzynek, A., Weiglhofer, F. T., Wenzel, S. C., Wessels, J. P., Wiechula, J., Wikne, J., Wilk, G., Wilkinson, J., Willems, G. A., Windelband, B., Winn, M., Wright, J. R., Wu, W., Wu, Y., Xiong, Z., Xu, R., Yadav, A., Yadav, A. K., Yalcin, S., Yamaguchi, Y., Yang, S., Yano, S., Yeats, E. R., Yin, Z., Yoo, I.-K., Yoon, J. H., Yu, H., Yuan, S., Yuncu, A., Zaccolo, V., Zampolli, C., Zanone, F., Zardoshti, N., Zarochentsev, A., Závada, P., Zaviyalov, N., Zhalov, M., Zhang, B., Zhang, C., Zhang, L., Zhang, M., Zhang, S., Zhang, X., Zhang, Y., Zhang, Z., Zhao, M., Zherebchevskii, V., Zhi, Y., Zhong, C., Zhou, D., Zhou, Y., Zhu, J., Zhu, Y., Zugravel, S. C., and Zurlo, N.
Published: 2024
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31. Measurement of beauty-quark production in pp collisions at s = 13 TeV via non-prompt D mesons

Author: Acharya, S., Adamová, D., Agarwal, A., Aglieri Rinella, G., Aglietta, L., Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S. U., Ahuja, I., Akindinov, A., Akishina, V., Al-Turany, M., Aleksandrov, D., Alessandro, B., Alfanda, H. M., Alfaro Molina, R., Ali, B., Alici, A., Alizadehvandchali, N., Alkin, A., Alme, J., Alocco, G., Alt, T., Altamura, A. R., Altsybeev, I., Alvarado, J. R., Anaam, M. N., Andrei, C., Andreou, N., Andronic, A., Andronov, E., Anguelov, V., Antinori, F., Antonioli, P., Apadula, N., Aphecetche, L., Appelshäuser, H., Arata, C., Arcelli, S., Aresti, M., Arnaldi, R., Arneiro, J. G. M. C. A., Arsene, I. C., Arslandok, M., Augustinus, A., Averbeck, R., Azmi, M. D., Baba, H., Badalà, A., Bae, J., Baek, Y. W., Bai, X., Bailhache, R., Bailung, Y., Bala, R., Balbino, A., Baldisseri, A., Balis, B., Banerjee, D., Banoo, Z., Barile, F., Barioglio, L., Barlou, M., Barman, B., Barnaföldi, G. G., Barnby, L. S., Barreau, E., Barret, V., Barreto, L., Bartels, C., Barth, K., Bartsch, E., Bastid, N., Basu, S., Batigne, G., Battistini, D., Batyunya, B., Bauri, D., Bazo Alba, J. L., Bearden, I. G., Beattie, C., Becht, P., Behera, D., Belikov, I., Bell Hechavarria, A. D. C., Bellini, F., Bellwied, R., Belokurova, S., Beltran, L. G. E., Beltran, Y. A. V., Bencedi, G., Bensaoula, A., Beole, S., Berdnikov, Y., Berdnikova, A., Bergmann, L., Besoiu, M. G., Betev, L., Bhaduri, P. P., Bhasin, A., Bhat, M. A., Bhattacharjee, B., Bianchi, L., Bianchi, N., Bielčík, J., Bielčíková, J., Bigot, A. P., Bilandzic, A., Biro, G., Biswas, S., Bize, N., Blair, J. T., Blau, D., Blidaru, M. B., Bluhme, N., Blume, C., Boca, G., Bock, F., Bodova, T., Bok, J., Boldizsár, L., Bombara, M., Bond, P. M., Bonomi, G., Borel, H., Borissov, A., Borquez Carcamo, A. G., Bossi, H., Botta, E., Bouziani, Y. E. M., Bratrud, L., Braun-Munzinger, P., Bregant, M., Broz, M., Bruno, G. E., Buckland, M. D., Budnikov, D., Buesching, H., Bufalino, S., Buhler, P., Burmasov, N., Buthelezi, Z., Bylinkin, A., Bysiak, S. A., Cabanillas Noris, J. C., Cabrera, M. F. T., Cai, M., Caines, H., Caliva, A., Calvo Villar, E., Camacho, J. M. M., Camerini, P., Canedo, F. D. M., Cantway, S. L., Carabas, M., Carballo, A. A., Carnesecchi, F., Caron, R., Carvalho, L. A. D., Castillo Castellanos, J., Castoldi, M., Catalano, F., Cattaruzzi, S., Ceballos Sanchez, C., Cerri, R., Chakaberia, I., Chakraborty, P., Chandra, S., Chapeland, S., Chartier, M., Chattopadhay, S., Chattopadhyay, S., Chattopadhyay, S., Cheng, T., Cheshkov, C., Chibante Barroso, V., Chinellato, D. D., Chizzali, E. S., Cho, J., Cho, S., Chochula, P., Choudhury, D., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Ciacco, M., Cicalo, C., Ciupek, M. R., Clai, G., Colamaria, F., Colburn, J. S., Colella, D., Colocci, M., Concas, M., Conesa Balbastre, G., Conesa del Valle, Z., Contin, G., Contreras, J. G., Coquet, M. 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A., Monira, S., Mordasini, C., Moreira De Godoy, D. A., Morozov, I., Morsch, A., Mrnjavac, T., Muccifora, V., Muhuri, S., Mulligan, J. D., Mulliri, A., Munhoz, M. G., Munzer, R. H., Murakami, H., Murray, S., Musa, L., Musinsky, J., Myrcha, J. W., Naik, B., Nambrath, A. I., Nandi, B. K., Nania, R., Nappi, E., Nassirpour, A. F., Nath, A., Nattrass, C., Naydenov, M. N., Neagu, A., Negru, A., Nekrasova, E., Nellen, L., Nepeivoda, R., Nese, S., Neskovic, G., Nicassio, N., Nielsen, B. S., Nielsen, E. G., Nikolaev, S., Nikulin, S., Nikulin, V., Noferini, F., Noh, S., Nomokonov, P., Norman, J., Novitzky, N., Nowakowski, P., Nyanin, A., Nystrand, J., Oh, S., Ohlson, A., Okorokov, V. A., Oleniacz, J., Onnerstad, A., Oppedisano, C., Ortiz Velasquez, A., Otwinowski, J., Oya, M., Oyama, K., Pachmayer, Y., Padhan, S., Pagano, D., Paić, G., Paisano-Guzmán, S., Palasciano, A., Panebianco, S., Park, H., Park, H., Parkkila, J. E., Patley, Y., Paul, B., Paulino, M. M. D. M., Pei, H., Peitzmann, T., Peng, X., Pennisi, M., Perciballi, S., Peresunko, D., Perez, G. M., Pestov, Y., Petrov, V., Petrovici, M., Pezzi, R. P., Piano, S., Pikna, M., Pillot, P., Pinazza, O., Pinsky, L., Pinto, C., Pisano, S., Płoskoń, M., Planinic, M., Pliquett, F., Poghosyan, M. G., Polichtchouk, B., Politano, S., Poljak, N., Pop, A., Porteboeuf-Houssais, S., Pozdniakov, V., Pozos, I. Y., Pradhan, K. K., Prasad, S. K., Prasad, S., Preghenella, R., Prino, F., Pruneau, C. A., Pshenichnov, I., Puccio, M., Pucillo, S., Qiu, S., Quaglia, L., Ragoni, S., Rai, A., Rakotozafindrabe, A., Ramello, L., Rami, F., Rasa, M., Räsänen, S. S., Rath, R., Rauch, M. P., Ravasenga, I., Read, K. F., Reckziegel, C., Redelbach, A. R., Redlich, K., Reetz, C. A., Regules-Medel, H. D., Rehman, A., Reidt, F., Reme-Ness, H. A., Rescakova, Z., Reygers, K., Riabov, A., Riabov, V., Ricci, R., Richter, M., Riedel, A. A., Riegler, W., Riffero, A. G., Ripoli, C., Ristea, C., Rodriguez, M. V., Rodríguez Cahuantzi, M., Rodríguez Ramírez, S. A., Røed, K., Rogalev, R., Rogochaya, E., Rogoschinski, T. S., Rohr, D., Röhrich, D., Rojas Torres, S., Rokita, P. S., Romanenko, G., Ronchetti, F., Rosas, E. D., Roslon, K., Rossi, A., Roy, A., Roy, S., Rubini, N., Ruggiano, D., Rui, R., Russek, P. G., Russo, R., Rustamov, A., Ryabinkin, E., Ryabov, Y., Rybicki, A., Ryu, J., Rzesa, W., Saarimaki, O. A. M., Sadhu, S., Sadovsky, S., Saetre, J., Šafařík, K., Saha, S. K., Saha, S., Sahoo, B., Sahoo, R., Sahoo, S., Sahu, D., Sahu, P. K., Saini, J., Sajdakova, K., Sakai, S., Salvan, M. P., Sambyal, S., Samitz, D., Sanna, I., Saramela, T. B., Sarkar, D., Sarma, P., Sarritzu, V., Sarti, V. M., Sas, M. H. P., Sawan, S., Scapparone, E., Schambach, J., Scheid, H. S., Schiaua, C., Schicker, R., Schlepper, F., Schmah, A., Schmidt, C., Schmidt, H. R., Schmidt, M. O., Schmidt, M., Schmidt, N. V., Schmier, A. R., Schotter, R., Schröter, A., Schukraft, J., Schweda, K., Scioli, G., Scomparin, E., Seger, J. E., Sekiguchi, Y., Sekihata, D., Selina, M., Selyuzhenkov, I., Senyukov, S., Seo, J. J., Serebryakov, D., Serkin, L., Šerkšnytė, L., Sevcenco, A., Shaba, T. J., Shabetai, A., Shahoyan, R., Shangaraev, A., Sharma, B., Sharma, D., Sharma, H., Sharma, M., Sharma, S., Sharma, S., Sharma, U., Shatat, A., Sheibani, O., Shigaki, K., Shimomura, M., Shin, J., Shirinkin, S., Shou, Q., Sibiriak, Y., Siddhanta, S., Siemiarczuk, T., Silva, T. F., Silvermyr, D., Simantathammakul, T., Simeonov, R., Singh, B., Singh, B., Singh, K., Singh, R., Singh, R., Singh, R., Singh, S., Singh, V. K., Singhal, V., Sinha, T., Sitar, B., Sitta, M., Skaali, T. B., Skorodumovs, G., Smirnov, N., Snellings, R. J. M., Solheim, E. H., Song, J., Sonnabend, C., Sonneveld, J. M., Soramel, F., Soto-hernandez, A. B., Spijkers, R., Sputowska, I., Staa, J., Stachel, J., Stan, I., Steffanic, P. J., Stiefelmaier, S. 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R., van Leeuwen, M., van Veen, C. A., van Weelden, R. J. G., Vande Vyvre, P., Varga, D., Varga, Z., Vargas Torres, P., Vasileiou, M., Vasiliev, A., Vázquez Doce, O., Vazquez Rueda, O., Vechernin, V., Vercellin, E., Vergara Limón, S., Verma, R., Vermunt, L., Vértesi, R., Verweij, M., Vickovic, L., Vilakazi, Z., Villalobos Baillie, O., Villani, A., Vinogradov, A., Virgili, T., Virta, M. M. O., Vislavicius, V., Vodopyanov, A., Volkel, B., Völkl, M. A., Voloshin, S. A., Volpe, G., von Haller, B., Vorobyev, I., Vozniuk, N., Vrláková, J., Wan, J., Wang, C., Wang, D., Wang, Y., Wang, Y., Wegrzynek, A., Weiglhofer, F. T., Wenzel, S. C., Wessels, J. P., Wiechula, J., Wikne, J., Wilk, G., Wilkinson, J., Willems, G. A., Windelband, B., Winn, M., Wright, J. R., Wu, W., Wu, Y., Xiong, Z., Xu, R., Yadav, A., Yadav, A. K., Yalcin, S., Yamaguchi, Y., Yang, S., Yano, S., Yeats, E. R., Yin, Z., Yoo, I.-K., Yoon, J. H., Yu, H., Yuan, S., Yuncu, A., Zaccolo, V., Zampolli, C., Zang, M., Zanone, F., Zardoshti, N., Zarochentsev, A., Závada, P., Zaviyalov, N., Zhalov, M., Zhang, B., Zhang, C., Zhang, L., Zhang, M., Zhang, S., Zhang, X., Zhang, Y., Zhang, Z., Zhao, M., Zherebchevskii, V., Zhi, Y., Zhong, C., Zhou, D., Zhou, Y., Zhu, J., Zhu, Y., Zugravel, S. C., and Zurlo, N.
Published: 2024
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32. Treatment outcomes of HIV-positive patients on first-line antiretroviral therapy in private versus public HIV clinics in Johannesburg, South Africa

Author: Moyo F, Chasela C, Brennan AT, Ebrahim O, Sanne IM, Long L, and Evans D
Subjects: ART, treatment outcomes, public-private partnerships, Infectious and parasitic diseases, RC109-216
Abstract: Faith Moyo,1 Charles Chasela,2,3 Alana T Brennan,1,4 Osman Ebrahim,5 Ian M Sanne,1,6 Lawrence Long,1 Denise Evans1 1Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 2Epidemiology and Biostatistics Department, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 3Epidemiology and Strategic Information (ESI), HIV/AIDS/STIs and TB, Human Sciences Research Council, Pretoria, South Africa; 4Center for Global Health and Development, Boston University, Boston, MA, USA; 5Brenthurst Clinic, Parktown, South Africa; 6Right to Care, Helen Joseph Hospital, Westdene, Johannesburg, South Africa Background: Despite the widely documented success of antiretroviral therapy (ART), stakeholders continue to face the challenges of poor HIV treatment outcomes. While many studies have investigated patient-level causes of poor treatment outcomes, data on the effect of health systems on ART outcomes are scarce.Objective: We compare treatment outcomes among patients receiving HIV care and treatment at a public and private HIV clinic in Johannesburg, South Africa.Patients and methods: This was a retrospective cohort analysis of ART naïve adults (≥18.0 years), initiating ART at a public or private clinic in Johannesburg between July 01, 2007 and December 31, 2012. Cox proportional-hazards regression was used to identify baseline predictors of mortality and loss to follow-up (>3 months late for the last scheduled visit). Generalized estimating equations were used to determine predictors of failure to suppress viral load (≥400 copies/mL) while the Wilcoxon rank-sum test was used to compare the median absolute change in CD4 count from baseline to 12 months post-ART initiation.Results: 12,865 patients initiated ART at the public clinic compared to 610 at the private clinic. The patients were similar in terms of sex and age at initiation. Compared to public clinic patients, private clinic patients initiated ART at higher median CD4 counts (159 vs 113 cells/mm3) and World Health Organization stage I/II (76.1% vs 58.5%). Adjusted hazard models showed that compared to public clinic patients, private clinic patients were less likely to die (adjusted hazard ratio [aHR] 0.50; 95% confidence interval [CI] 0.35–0.70) but were at increased risk of loss to follow-up (aHR 1.80; 95% CI 1.59–2.03). By 12 months post-ART initiation, private clinic patients were less likely to have a detectable viral load (adjusted relative risk 0.65; 95% CI 0.49–0.88) and recorded higher median CD4 change from baseline (184 cells/mm3 interquartile range 101–300 vs 158 cells/mm3 interquartile range 91–244), when compared to public clinic patients.Conclusion: We identified differences in treatment outcomes between the two HIV clinics. Findings suggest that the type of clinic at which ART patients initiate and receive treatment can have an impact on treatment outcomes. Further research is necessary to provide more conclusive results. Keywords: health systems, attrition, HIV programs, viral suppression
Published: 2016

33. Cascade screening in HBOC and Lynch syndrome: guidelines and procedures in a UK centre

Author: Evans, D. Gareth, Green, Kate, Burghel, George J., Forde, Claire, Lalloo, Fiona, Schlecht, Helene, and Woodward, Emma R.
Published: 2024
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34. Centralised Design and Production of the Ultra-High Vacuum and Laser-Stabilisation Systems for the AION Ultra-Cold Strontium Laboratories

Author: Stray, B., Ennis, O., Hedges, S., Dey, S., Langlois, M., Bongs, K., Lellouch, S., Holynski, M., Bostwick, B., Chen, J., Eyler, Z., Gibson, V., Harte, T. L., Hsu, M., Karzazi, M., Mitchell, J., Mouelle, N., Schneider, U., Tang, Y., Tkalcec, K., Zhi, Y., Clarke, K., Vick, A., Bridges, K., Coleman, J., Elertas, G., Hawkins, L., Hindley, S., Hussain, K., Metelko, C., Throssell, H., Baynham, C. F. A., Buchmuller, O., Evans, D., Hobson, R., Iannizzotto-Venezze, L., Josset, A., Pasatembou, E., Sauer, B. E., Tarbutt, M. R., Badurina, L, Beniwal, A., Blas, D., Carlton, J., Ellis, J., McCabe, C., Bentine, E., Booth, M., Bortoletto, D., Foot, C., Gomez, C., Hird, T., Hughes, K., James, A., Lowe, A., March-Russell, J., Schelfhout, J., Shipsey, I., Weatherill, D., Wood, D., Balashov, S., Bason, M. G., Boehm, J., Courthold, M., van der Grinten, M., Majewski, P., Marchant, A. L., Newbold, D., Pan, Z., Tam, Z., Valenzuela, T., and Wilmut, I.
Subjects: Physics - Atomic Physics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors, Quantum Physics
Abstract: This paper outlines the centralised design and production of the Ultra-High-Vacuum sidearm and Laser-Stabilisation systems for the AION Ultra-Cold Strontium Laboratories. Commissioning data on the residual gas and steady-state pressures in the sidearm chambers, on magnetic field quality, on laser stabilisation, and on the loading rate for the 3D Magneto-Optical Trap are presented. Streamlining the design and production of the sidearm and laser stabilisation systems enabled the AION Collaboration to build and equip in parallel five state-of-the-art Ultra-Cold Strontium Laboratories within 24 months by leveraging key expertise in the collaboration. This approach could serve as a model for the development and construction of other cold atom experiments, such as atomic clock experiments and neutral atom quantum computing systems, by establishing dedicated design and production units at national laboratories., Comment: 27 pages, 21 figures
Published: 2023

35. Investigating strangeness enhancement with multiplicity in pp collisions using angular correlations

Author: Acharya, S., Adamová, D., Agarwal, A., Aglieri Rinella, G., Aglietta, L., Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S. U., Ahuja, I., Akindinov, A., Akishina, V., Al-Turany, M., Aleksandrov, D., Alessandro, B., Alfanda, H. M., Alfaro Molina, R., Ali, B., Alici, A., Alizadehvandchali, N., Alkin, A., Alme, J., Alocco, G., Alt, T., Altamura, A. R., Altsybeev, I., Alvarado, J. R., Alvarez, C. O. R., Anaam, M. N., Andrei, C., Andreou, N., Andronic, A., Andronov, E., Anguelov, V., Antinori, F., Antonioli, P., Apadula, N., Aphecetche, L., Appelshäuser, H., Arata, C., Arcelli, S., Aresti, M., Arnaldi, R., Arneiro, J. G. M. C. A., Arsene, I. C., Arslandok, M., Augustinus, A., Averbeck, R., Azmi, M. D., Baba, H., Badalà, A., Bae, J., Baek, Y. W., Bai, X., Bailhache, R., Bailung, Y., Bala, R., Balbino, A., Baldisseri, A., Balis, B., Banerjee, D., Banoo, Z., Barbasova, V., Barile, F., Barioglio, L., Barlou, M., Barman, B., Barnaföldi, G. G., Barnby, L. S., Barreau, E., Barret, V., Barreto, L., Bartels, C., Barth, K., Bartsch, E., Bastid, N., Basu, S., Batigne, G., Battistini, D., Batyunya, B., Bauri, D., Bazo Alba, J. L., Bearden, I. G., Beattie, C., Becht, P., Behera, D., Belikov, I., Bell Hechavarria, A. D. C., Bellini, F., Bellwied, R., Belokurova, S., Beltran, L. G. E., Beltran, Y. A. V., Bencedi, G., Bensaoula, A., Beole, S., Berdnikov, Y., Berdnikova, A., Bergmann, L., Besoiu, M. G., Betev, L., Bhaduri, P. P., Bhasin, A., Bhattacharjee, B., Bianchi, L., Bianchi, N., Bielčík, J., Bielčíková, J., Bigot, A. P., Bilandzic, A., Biro, G., Biswas, S., Bize, N., Blair, J. T., Blau, D., Blidaru, M. B., Bluhme, N., Blume, C., Boca, G., Bock, F., Bodova, T., Bok, J., Boldizsár, L., Bombara, M., Bond, P. M., Bonomi, G., Borel, H., Borissov, A., Borquez Carcamo, A. G., Bossi, H., Botta, E., Bouziani, Y. E. M., Bratrud, L., Braun-Munzinger, P., Bregant, M., Broz, M., Bruno, G. E., Buchakchiev, V. D., Buckland, M. D., Budnikov, D., Buesching, H., Bufalino, S., Buhler, P., Burmasov, N., Buthelezi, Z., Bylinkin, A., Bysiak, S. A., Cabanillas Noris, J. C., Cabrera, M. F. T., Cai, M., Caines, H., Caliva, A., Calvo Villar, E., Camacho, J. M. M., Camerini, P., Canedo, F. D. M., Cantway, S. L., Carabas, M., Carballo, A. A., Carnesecchi, F., Caron, R., Carvalho, L. A. D., Castillo Castellanos, J., Castoldi, M., Catalano, F., Cattaruzzi, S., Ceballos Sanchez, C., Cerri, R., Chakaberia, I., Chakraborty, P., Chandra, S., Chapeland, S., Chartier, M., Chattopadhay, S., Chattopadhyay, S., Chattopadhyay, S., Chen, M., Cheng, T., Cheshkov, C., Chibante Barroso, V., Chinellato, D. D., Chizzali, E. S., Cho, J., Cho, S., Chochula, P., Chochulska, Z. A., Choudhury, D., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Ciacco, M., Cicalo, C., Ciupek, M. R., Clai, G., Colamaria, F., Colburn, J. S., Colella, D., Colocci, M., Concas, M., Conesa Balbastre, G., Conesa del Valle, Z., Contin, G., Contreras, J. G., Coquet, M. L., Cortese, P., Cosentino, M. R., Costa, F., Costanza, S., Cot, C., Crkovská, J., Crochet, P., Cruz-Torres, R., Cui, P., Czarnynoga, M. M., Dainese, A., Dange, G., Danisch, M. C., Danu, A., Das, P., Das, P., Das, S., Dash, A. R., Dash, S., De Caro, A., de Cataldo, G., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Martin, C., De Pasquale, S., Deb, R., Del Grande, R., Dello Stritto, L., Deng, W., Devereaux, K. C., Dhankher, P., Di Bari, D., Di Mauro, A., Diab, B., Diaz, R. A., Dietel, T., Ding, Y., Ditzel, J., Divià, R., Djuvsland, Ø., Dmitrieva, U., Dobrin, A., Dönigus, B., Dubinski, J. M., Dubla, A., Dupieux, P., Dzalaiova, N., Eder, T. M., Ehlers, R. J., Eisenhut, F., Ejima, R., Elia, D., Erazmus, B., Ercolessi, F., Espagnon, B., Eulisse, G., Evans, D., Evdokimov, S., Fabbietti, L., Faggin, M., Faivre, J., Fan, F., Fan, W., Fantoni, A., Fasel, M., Feliciello, A., Feofilov, G., Fernández Téllez, A., Ferrandi, L., Ferrer, M. B., Ferrero, A., Ferrero, C., Ferretti, A., Feuillard, V. J. G., Filova, V., Finogeev, D., Fionda, F. M., Flatland, E., Flor, F., Flores, A. N., Foertsch, S., Fokin, I., Fokin, S., Follo, U., Fragiacomo, E., Frajna, E., Fuchs, U., Funicello, N., Furget, C., Furs, A., Fusayasu, T., Gaardhøje, J. J., Gagliardi, M., Gago, A. M., Gahlaut, T., Galvan, C. D., Gangadharan, D. R., Ganoti, P., Garabatos, C., Garcia, J. M., García Chávez, T., Garcia-Solis, E., Gargiulo, C., Gasik, P., Gaur, H. M., Gautam, A., Gay Ducati, M. B., Germain, M., Ghosh, C., Giacalone, M., Gioachin, G., Giubellino, P., Giubilato, P., Glaenzer, A. M. C., Glässel, P., Glimos, E., Goh, D. J. Q., Gonzalez, V., Gordeev, P., Gorgon, M., Goswami, K., Gotovac, S., Grabski, V., Graczykowski, L. K., Grecka, E., Grelli, A., Grigoras, C., Grigoriev, V., Grigoryan, S., Grosa, F., Grosse-Oetringhaus, J. F., Grosso, R., Grund, D., Grunwald, N. A., Guardiano, G. G., Guernane, R., Guilbaud, M., Gulbrandsen, K., Gumprecht, J. J. W. K., Gündem, T., Gunji, T., Guo, W., Gupta, A., Gupta, R., Gupta, R., Gwizdziel, K., Gyulai, L., Hadjidakis, C., Haider, F. U., Haidlova, S., Haldar, M., Hamagaki, H., Hamdi, A., Han, Y., Hanley, B. G., Hannigan, R., Hansen, J., Haque, M. R., Harris, J. W., Harton, A., Hartung, M. V., Hassan, H., Hatzifotiadou, D., Hauer, P., Havener, L. B., Hellbär, E., Helstrup, H., Hemmer, M., Herman, T., Hernandez, S. G., Herrera Corral, G., Herrmann, S., Hetland, K. F., Heybeck, B., Hillemanns, H., Hippolyte, B., Hoffmann, F. W., Hofman, B., Hong, G. H., Horst, M., Horzyk, A., Hou, Y., Hristov, P., Huhn, P., Huhta, L. M., Humanic, T. J., Hutson, A., Hutter, D., Hwang, M. C., Ilkaev, R., Inaba, M., Innocenti, G. M., Ippolitov, M., Isakov, A., Isidori, T., Islam, M. S., Iurchenko, S., Ivanov, M., Ivanov, M., Ivanov, V., Iversen, K. E., Jablonski, M., Jacak, B., Jacazio, N., Jacobs, P. M., Jadlovska, S., Jadlovsky, J., Jaelani, S., Jahnke, C., Jakubowska, M. J., Janik, M. A., Janson, T., Ji, S., Jia, S., Jimenez, A. A. P., Jonas, F., Jones, D. M., Jowett, J. M., Jung, J., Jung, M., Junique, A., Jusko, A., Kaewjai, J., Kalinak, P., Kalweit, A., Karasu Uysal, A., Karatovic, D., Karatzenis, N., Karavichev, O., Karavicheva, T., Karpechev, E., Karwowska, M. J., Kebschull, U., Keidel, R., Keil, M., Ketzer, B., Khade, S. S., Khan, A. M., Khan, S., Khanzadeev, A., Kharlov, Y., Khatun, A., Khuntia, A., Khuranova, Z., Kileng, B., Kim, B., Kim, C., Kim, D. J., Kim, E. J., Kim, J., Kim, J., Kim, J., Kim, M., Kim, S., Kim, T., Kimura, K., Kirkova, A., Kirsch, S., Kisel, I., Kiselev, S., Kisiel, A., Kitowski, J. P., Klay, J. L., Klein, J., Klein, S., Klein-Bösing, C., Kleiner, M., Klemenz, T., Kluge, A., Kobdaj, C., Kohara, R., Kollegger, T., Kondratyev, A., Kondratyeva, N., Konig, J., Konigstorfer, S. A., Konopka, P. J., Kornakov, G., Korwieser, M., Koryciak, S. D., Koster, C., Kotliarov, A., Kovacic, N., Kovalenko, V., Kowalski, M., Kozhuharov, V., Králik, I., Kravčáková, A., Krcal, L., Krivda, M., Krizek, F., Krizkova Gajdosova, K., Krug, C., Krüger, M., Krupova, D. M., Kryshen, E., Kučera, V., Kuhn, C., Kuijer, P. G., Kumaoka, T., Kumar, D., Kumar, L., Kumar, N., Kumar, S., Kundu, S., Kurashvili, P., Kurepin, A., Kurepin, A. B., Kuryakin, A., Kushpil, S., Kuskov, V., Kutyla, M., Kuznetsov, A., Kweon, M. J., Kwon, Y., La Pointe, S. L., La Rocca, P., Lakrathok, A., Lamanna, M., Landou, A. R., Langoy, R., Larionov, P., Laudi, E., Lautner, L., Laveaga, R. A. N., Lavicka, R., Lea, R., Lee, H., Legrand, I., Legras, G., Lehrbach, J., Lejeune, A. M., Lelek, T. M., Lemmon, R. C., León Monzón, I., Lesch, M. M., Lesser, E. D., Lévai, P., Li, M., Li, X., Liang-gilman, B. E., Lien, J., Lietava, R., Likmeta, I., Lim, B., Lim, S. H., Lindenstruth, V., Lindner, A., Lippmann, C., Liu, D. H., Liu, J., Liveraro, G. S. S., Lofnes, I. M., Loizides, C., Lokos, S., Lömker, J., Lopez, X., López Torres, E., Lu, P., Lugo, F. V., Luhder, J. R., Lunardon, M., Luparello, G., Ma, Y. G., Mager, M., Maire, A., Majerz, E. M., Makariev, M. V., Malaev, M., Malfattore, G., Malik, N. M., Malik, Q. W., Malik, S. K., Malinina, L., Mallick, D., Mallick, N., Mandaglio, G., Mandal, S. K., Manea, A., Manko, V., Manso, F., Manzari, V., Mao, Y., Marcjan, R. W., Margagliotti, G. V., Margotti, A., Marín, A., Markert, C., Martinengo, P., Martínez, M. I., Martínez García, G., Martins, M. P. P., Masciocchi, S., Masera, M., Masoni, A., Massacrier, L., Massen, O., Mastroserio, A., Matonoha, O., Mattiazzo, S., Matyja, A., Mazuecos, A. L., Mazzaschi, F., Mazzilli, M., Mdhluli, J. E., Melikyan, Y., Melo, M., Menchaca-Rocha, A., Mendez, J. E. M., Meninno, E., Menon, A. S., Menzel, M. W., Meres, M., Miake, Y., Micheletti, L., Mihaylov, D. L., Mikhaylov, K., Minafra, N., Miśkowiec, D., Modak, A., Mohanty, B., Mohisin Khan, M., Molander, M. A., Monira, S., Mordasini, C., Moreira De Godoy, D. A., Morozov, I., Morsch, A., Mrnjavac, T., Muccifora, V., Muhuri, S., Mulligan, J. D., Mulliri, A., Munhoz, M. G., Munzer, R. H., Murakami, H., Murray, S., Musa, L., Musinsky, J., Myrcha, J. W., Naik, B., Nambrath, A. I., Nandi, B. K., Nania, R., Nappi, E., Nassirpour, A. F., Nath, A., Nattrass, C., Naydenov, M. N., Neagu, A., Negru, A., Nekrasova, E., Nellen, L., Nepeivoda, R., Nese, S., Neskovic, G., Nicassio, N., Nielsen, B. S., Nielsen, E. G., Nikolaev, S., Nikulin, S., Nikulin, V., Noferini, F., Noh, S., Nomokonov, P., Norman, J., Novitzky, N., Nowakowski, P., Nyanin, A., Nystrand, J., Oh, S., Ohlson, A., Okorokov, V. A., Oleniacz, J., Onnerstad, A., Oppedisano, C., Ortiz Velasquez, A., Otwinowski, J., Oya, M., Oyama, K., Pachmayer, Y., Padhan, S., Pagano, D., Paić, G., Paisano-Guzmán, S., Palasciano, A., Panebianco, S., Pantouvakis, C., Park, H., Park, H., Park, J., Parkkila, J. E., Patley, Y., Paul, B., Pei, H., Peitzmann, T., Peng, X., Pennisi, M., Perciballi, S., Peresunko, D., Perez, G. M., Pestov, Y., Petersen, M. T., Petrov, V., Petrovici, M., Piano, S., Pikna, M., Pillot, P., Pinazza, O., Pinsky, L., Pinto, C., Pisano, S., Płoskoń, M., Planinic, M., Pliquett, F., Poghosyan, M. G., Polichtchouk, B., Politano, S., Poljak, N., Pop, A., Porteboeuf-Houssais, S., Pozdniakov, V., Pozos, I. Y., Pradhan, K. K., Prasad, S. K., Prasad, S., Preghenella, R., Prino, F., Pruneau, C. A., Pshenichnov, I., Puccio, M., Pucillo, S., Qiu, S., Quaglia, L., Ragoni, S., Rai, A., Rakotozafindrabe, A., Ramello, L., Rami, F., Rasa, M., Räsänen, S. S., Rath, R., Rauch, M. P., Ravasenga, I., Read, K. F., Reckziegel, C., Redelbach, A. R., Redlich, K., Reetz, C. A., Regules-Medel, H. D., Rehman, A., Reidt, F., Reme-Ness, H. A., Rescakova, Z., Reygers, K., Riabov, A., Riabov, V., Ricci, R., Richter, M., Riedel, A. A., Riegler, W., Riffero, A. G., Ripoli, C., Ristea, C., Rodriguez, M. V., Rodríguez Cahuantzi, M., Rodríguez Ramírez, S. A., Røed, K., Rogalev, R., Rogochaya, E., Rogoschinski, T. S., Rohr, D., Röhrich, D., Rojas Torres, S., Rokita, P. S., Romanenko, G., Ronchetti, F., Rosas, E. D., Roslon, K., Rossi, A., Roy, A., Roy, S., Rubini, N., Rudolph, J. A., Ruggiano, D., Rui, R., Russek, P. G., Russo, R., Rustamov, A., Ryabinkin, E., Ryabov, Y., Rybicki, A., Ryu, J., Rzesa, W., Sadhu, S., Sadovsky, S., Saetre, J., Šafařík, K., Saha, S. K., Saha, S., Sahoo, B., Sahoo, R., Sahoo, S., Sahu, D., Sahu, P. K., Saini, J., Sajdakova, K., Sakai, S., Salvan, M. P., Sambyal, S., Samitz, D., Sanna, I., Saramela, T. B., Sarkar, D., Sarma, P., Sarritzu, V., Sarti, V. M., Sas, M. H. P., Sawan, S., Scapparone, E., Schambach, J., Scheid, H. S., Schiaua, C., Schicker, R., Schlepper, F., Schmah, A., Schmidt, C., Schmidt, H. R., Schmidt, M. O., Schmidt, M., Schmidt, N. V., Schmier, A. R., Schotter, R., Schröter, A., Schukraft, J., Schweda, K., Scioli, G., Scomparin, E., Seger, J. E., Sekiguchi, Y., Sekihata, D., Selina, M., Selyuzhenkov, I., Senyukov, S., Seo, J. J., Serebryakov, D., Serkin, L., Šerkšnytė, L., Sevcenco, A., Shaba, T. J., Shabetai, A., Shahoyan, R., Shangaraev, A., Sharma, B., Sharma, D., Sharma, H., Sharma, M., Sharma, S., Sharma, S., Sharma, U., Shatat, A., Sheibani, O., Shigaki, K., Shimomura, M., Shin, J., Shirinkin, S., Shou, Q., Sibiriak, Y., Siddhanta, S., Siemiarczuk, T., Silva, T. F., Silvermyr, D., Simantathammakul, T., Simeonov, R., Singh, B., Singh, B., Singh, K., Singh, R., Singh, R., Singh, R., Singh, S., Singh, V. K., Singhal, V., Sinha, T., Sitar, B., Sitta, M., Skaali, T. B., Skorodumovs, G., Smirnov, N., Snellings, R. J. M., Solheim, E. H., Song, J., Sonnabend, C., Sonneveld, J. M., Soramel, F., Soto-hernandez, A. B., Spijkers, R., Sputowska, I., Staa, J., Stachel, J., Stan, I., Steffanic, P. J., Stiefelmaier, S. F., Stocco, D., Storehaug, I., Strangmann, N. J., Stratmann, P., Strazzi, S., Sturniolo, A., Stylianidis, C. P., Suaide, A. A. P., Suire, C., Sukhanov, M., Suljic, M., Sultanov, R., Sumberia, V., Sumowidagdo, S., Szarka, I., Szymkowski, M., Taghavi, S. F., Taillepied, G., Takahashi, J., Tambave, G. J., Tang, S., Tang, Z., Tapia Takaki, J. D., Tapus, N., Tarasovicova, L. A., Tarzila, M. G., Tassielli, G. F., Tauro, A., Tavira García, A., Tejeda Muñoz, G., Telesca, A., Terlizzi, L., Terrevoli, C., Thakur, S., Thomas, D., Tikhonov, A., Tiltmann, N., Timmins, A. R., Tkacik, M., Tkacik, T., Toia, A., Tokumoto, R., Tomassini, S., Tomohiro, K., Topilskaya, N., Toppi, M., Tork, T., Torres, V. V., Torres Ramos, A. G., Trifiró, A., Triloki, T., Triolo, A. S., Tripathy, S., Tripathy, T., Trubnikov, V., Trzaska, W. H., Trzcinski, T. P., Tsolanta, C., Tu, R., Tumkin, A., Turrisi, R., Tveter, T. S., Ullaland, K., Ulukutlu, B., Uras, A., Urioni, M., Usai, G. L., Vala, M., Valle, N., van Doremalen, L. V. R., van Leeuwen, M., van Veen, C. A., van Weelden, R. J. G., Vande Vyvre, P., Varga, D., Varga, Z., Vargas Torres, P., Vasileiou, M., Vasiliev, A., Vázquez Doce, O., Vazquez Rueda, O., Vechernin, V., Vercellin, E., Vergara Limón, S., Verma, R., Vermunt, L., Vértesi, R., Verweij, M., Vickovic, L., Vilakazi, Z., Villalobos Baillie, O., Villani, A., Vinogradov, A., Virgili, T., Virta, M. M. O., Vislavicius, V., Vodopyanov, A., Volkel, B., Völkl, M. A., Voloshin, S. A., Volpe, G., von Haller, B., Vorobyev, I., Vozniuk, N., Vrláková, J., Wan, J., Wang, C., Wang, D., Wang, Y., Wang, Y., Wegrzynek, A., Weiglhofer, F. T., Wenzel, S. C., Wessels, J. P., Wiechula, J., Wikne, J., Wilk, G., Wilkinson, J., Willems, G. A., Windelband, B., Winn, M., Wright, J. R., Wu, W., Wu, Y., Xiong, Z., Xu, R., Yadav, A., Yadav, A. K., Yamaguchi, Y., Yang, S., Yano, S., Yeats, E. R., Yin, Z., Yoo, I.-K., Yoon, J. H., Yu, H., Yuan, S., Yuncu, A., Zaccolo, V., Zampolli, C., Zanone, F., Zardoshti, N., Zarochentsev, A., Závada, P., Zaviyalov, N., Zhalov, M., Zhang, B., Zhang, C., Zhang, L., Zhang, M., Zhang, M., Zhang, S., Zhang, X., Zhang, Y., Zhang, Z., Zhao, M., Zherebchevskii, V., Zhi, Y., Zhou, D., Zhou, Y., Zhu, J., Zhu, S., Zhu, Y., Zugravel, S. C., and Zurlo, N.
Published: 2024
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36. Studying strangeness and baryon production mechanisms through angular correlations between charged Ξ baryons and identified hadrons in pp collisions at s = 13 TeV

Author: Acharya, S., Adamová, D., Adolfsson, J., Aglieri Rinella, G., Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S. U., Ahuja, I., Akindinov, A., Al-Turany, M., Aleksandrov, D., Alessandro, B., Alfanda, H. M., Alfaro Molina, R., Ali, B., Alici, A., Alizadehvandchali, N., Alkin, A., Alme, J., Alocco, G., Alt, T., Altamura, A. R., Altsybeev, I., Alvarado, J. R., Anaam, M. N., Andrei, C., Andreou, N., Andronic, A., Anguelov, V., Antinori, F., Antonioli, P., Apadula, N., Aphecetche, L., Appelshäuser, H., Arata, C., Arcelli, S., Aresti, M., Arnaldi, R., Arneiro, J. G. M. C. A., Arsene, I. C., Arslandok, M., Augustinus, A., Averbeck, R., Azmi, M. D., Baba, H., Badalà, A., Bae, J., Baek, Y. W., Bai, X., Bailhache, R., Bailung, Y., Balbino, A., Baldisseri, A., Balis, B., Banerjee, D., Banoo, Z., Barbera, R., Barile, F., Barioglio, L., Barlou, M., Barman, B., Barnaföldi, G. G., Barnby, L. S., Barret, V., Barreto, L., Bartels, C., Barth, K., Bartsch, E., Bastid, N., Basu, S., Batigne, G., Battistini, D., Batyunya, B., Bauri, D., Bazo Alba, J. L., Bearden, I. G., Beattie, C., Becht, P., Behera, D., Belikov, I., Bell Hechavarria, A. D. C., Bellini, F., Bellwied, R., Belokurova, S., Beltran, Y. A. V., Bencedi, G., Beole, S., Berdnikov, Y., Berdnikova, A., Bergmann, L., Besoiu, M. G., Betev, L., Bhaduri, P. P., Bhasin, A., Bhat, M. A., Bhattacharjee, B., Bianchi, L., Bianchi, N., Bielčík, J., Bielčíková, J., Biernat, J., Bigot, A. P., Bilandzic, A., Biro, G., Biswas, S., Bize, N., Blair, J. T., Blau, D., Blidaru, M. B., Bluhme, N., Blume, C., Boca, G., Bock, F., Bodova, T., Bogdanov, A., Boi, S., Bok, J., Boldizsár, L., Bombara, M., Bond, P. M., Bonomi, G., Borel, H., Borissov, A., Borquez Carcamo, A. G., Bossi, H., Botta, E., Bouziani, Y. E. M., Bratrud, L., Braun-Munzinger, P., Bregant, M., Broz, M., Bruno, G. E., Buckland, M. D., Budnikov, D., Buesching, H., Bufalino, S., Buhler, P., Burmasov, N., Buthelezi, Z., Bylinkin, A., Bysiak, S. A., Cai, M., Caines, H., Caliva, A., Calvo Villar, E., Camacho, J. M. M., Camerini, P., Canedo, F. D. M., Cantway, S. L., Carabas, M., Carballo, A. A., Carnesecchi, F., Caron, R., Carvalho, L. A. D., Castillo Castellanos, J., Catalano, F., Ceballos Sanchez, C., Chakaberia, I., Chakraborty, P., Chandra, S., Chapeland, S., Chartier, M., Chattopadhyay, S., Chattopadhyay, S., Cheng, T., Cheshkov, C., Cheynis, B., Chibante Barroso, V., Chinellato, D. D., Chizzali, E. S., Cho, J., Cho, S., Chochula, P., Choudhury, D., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Ciacco, M., Cicalo, C., Cindolo, F., Ciupek, M. R., Clai, G., Colamaria, F., Colburn, J. S., Colella, D., Colocci, M., Concas, M., Conesa Balbastre, G., Conesa del Valle, Z., Contin, G., Contreras, J. G., Coquet, M. L., Cortese, P., Cosentino, M. 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Published: 2024
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37. Azimuthal anisotropy of jet particles in p-Pb and Pb-Pb collisions at sNN = 5.02 TeV

Author: Acharya, S., Adamová, D., Adler, A., Aglieri Rinella, G., Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S. U., Ahuja, I., Akindinov, A., Al-Turany, M., Aleksandrov, D., Alessandro, B., Alfanda, H. M., Alfaro Molina, R., Ali, B., Alici, A., Alizadehvandchali, N., Alkin, A., Alme, J., Alocco, G., Alt, T., Altsybeev, I., Alvarado, J. R., Anaam, M. N., Andrei, C., Andronic, A., Anguelov, V., Antinori, F., Antonioli, P., Apadula, N., Aphecetche, L., Appelshäuser, H., Arata, C., Arcelli, S., Aresti, M., Arnaldi, R., Arneiro, J. G. M. C. A., Arsene, I. C., Arslandok, M., Augustinus, A., Averbeck, R., Azmi, M. D., Badalà, A., Bae, J., Baek, Y. W., Bai, X., Bailhache, R., Bailung, Y., Balbino, A., Baldisseri, A., Balis, B., Banerjee, D., Banoo, Z., Barbera, R., Barile, F., Barioglio, L., Barlou, M., Barnaföldi, G. G., Barnby, L. S., Barret, V., Barreto, L., Bartels, C., Barth, K., Bartsch, E., Bastid, N., Basu, S., Batigne, G., Battistini, D., Batyunya, B., Bauri, D., Bazo Alba, J. L., Bearden, I. G., Beattie, C., Becht, P., Behera, D., Belikov, I., Bell Hechavarria, A. D. C., Bellini, F., Bellwied, R., Belokurova, S., Belyaev, V., Bencedi, G., Beole, S., Berdnikov, Y., Berdnikova, A., Bergmann, L., Besoiu, M. G., Betev, L., Bhaduri, P. P., Bhasin, A., Bhat, M. A., Bhattacharjee, B., Bianchi, L., Bianchi, N., Bielčík, J., Bielčíková, J., Biernat, J., Bigot, A. P., Bilandzic, A., Biro, G., Biswas, S., Bize, N., Blair, J. T., Blau, D., Blidaru, M. B., Bluhme, N., Blume, C., Boca, G., Bock, F., Bodova, T., Bogdanov, A., Boi, S., Bok, J., Boldizsár, L., Bombara, M., Bond, P. M., Bonomi, G., Borel, H., Borissov, A., Borquez Carcamo, A. G., Bossi, H., Botta, E., Bouziani, Y. E. M., Bratrud, L., Braun-Munzinger, P., Bregant, M., Broz, M., Bruno, G. E., Buckland, M. D., Budnikov, D., Buesching, H., Bufalino, S., Bugnon, O., Buhler, P., Buthelezi, Z., Bysiak, S. A., Cai, M., Caines, H., Caliva, A., Calvo Villar, E., Camacho, J. M. M., Camerini, P., Canedo, F. D. M., Cantway, S. L., Carabas, M., Carballo, A. A., Carnesecchi, F., Caron, R., Carvalho, L. A. D., Castillo Castellanos, J., Catalano, F., Ceballos Sanchez, C., Chakaberia, I., Chakraborty, P., Chandra, S., Chapeland, S., Chartier, M., Chattopadhyay, S., Chattopadhyay, S., Cheng, T., Cheshkov, C., Cheynis, B., Chibante Barroso, V., Chinellato, D. D., Chizzali, E. S., Cho, J., Cho, S., Chochula, P., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Ciacco, M., Cicalo, C., Cindolo, F., Ciupek, M. R., Clai, G., Colamaria, F., Colburn, J. S., Colella, D., Colocci, M., Concas, M., Conesa Balbastre, G., Conesa del Valle, Z., Contin, G., Contreras, J. G., Coquet, M. L., Cormier, T. M., Cortese, P., Cosentino, M. R., Costa, F., Costanza, S., Cot, C., Crkovská, J., Crochet, P., Cruz-Torres, R., Cuautle, E., Cui, P., Dainese, A., Danisch, M. C., Danu, A., Das, P., Das, P., Das, S., Dash, A. R., Dash, S., De Caro, A., de Cataldo, G., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Martin, C., De Pasquale, S., Deb, R., Deb, S., Debski, R. J., Deja, K. R., Del Grande, R., Dello Stritto, L., Deng, W., Dhankher, P., Di Bari, D., Di Mauro, A., Diaz, R. A., Dietel, T., Ding, Y., Divià, R., Dixit, D. U., Djuvsland, Ø., Dmitrieva, U., Dobrin, A., Dönigus, B., Dubinski, J. M., Dubla, A., Dudi, S., Dupieux, P., Durkac, M., Dzalaiova, N., Eder, T. M., Ehlers, R. J., Eikeland, V. N., Eisenhut, F., Elia, D., Erazmus, B., Ercolessi, F., Erhardt, F., Ersdal, M. R., Espagnon, B., Eulisse, G., Evans, D., Evdokimov, S., Fabbietti, L., Faggin, M., Faivre, J., Fan, F., Fan, W., Fantoni, A., Fasel, M., Fecchio, P., Feliciello, A., Feofilov, G., Fernández Téllez, A., Ferrandi, L., Ferrer, M. B., Ferrero, A., Ferrero, C., Ferretti, A., Feuillard, V. J. G., Filova, V., Finogeev, D., Fionda, F. M., Flor, F., Flores, A. N., Foertsch, S., Fokin, I., Fokin, S., Fragiacomo, E., Frajna, E., Fuchs, U., Funicello, N., Furget, C., Furs, A., Fusayasu, T., Gaardhøje, J. J., Gagliardi, M., Gago, A. M., Galvan, C. D., Gangadharan, D. R., Ganoti, P., Garabatos, C., García Chávez, T., Garcia-Solis, E., Garg, K., Gargiulo, C., Garner, K., Gasik, P., Gautam, A., Gay Ducati, M. B., Germain, M., Ghimouz, A., Ghosh, C., Giacalone, M., Giubellino, P., Giubilato, P., Glaenzer, A. M. C., Glässel, P., Glimos, E., Goh, D. J. Q., Gonzalez, V., González-Trueba, L. H., Gorgon, M., Gotovac, S., Grabski, V., Graczykowski, L. K., Grecka, E., Grelli, A., Grigoras, C., Grigoriev, V., Grigoryan, S., Grosa, F., Grosse-Oetringhaus, J. F., Grosso, R., Grund, D., Guardiano, G. G., Guernane, R., Guilbaud, M., Gulbrandsen, K., Gündem, T., Gunji, T., Guo, W., Gupta, A., Gupta, R., Gyulai, L., Habib, M. K., Hadjidakis, C., Haider, F. U., Hamagaki, H., Hamdi, A., Hamid, M., Han, Y., Hannigan, R., Haque, M. R., Harris, J. W., Harton, A., Hassan, H., Hatzifotiadou, D., Hauer, P., Havener, L. B., Heckel, S. T., Hellbär, E., Helstrup, H., Hemmer, M., Herman, T., Herrera Corral, G., Herrmann, F., Herrmann, S., Hetland, K. F., Heybeck, B., Hillemanns, H., Hills, C., Hippolyte, B., Hoffmann, F. W., Hofman, B., Hohlweger, B., Hong, G. H., Horst, M., Horzyk, A., Hou, Y., Hristov, P., Hughes, C., Huhn, P., Huhta, L. M., Humanic, T. J., Hutson, A., Hutter, D., Iddon, J. P., Ilkaev, R., Ilyas, H., Inaba, M., Innocenti, G. M., Ippolitov, M., Isakov, A., Isidori, T., Islam, M. S., Ivanov, M., Ivanov, M., Ivanov, V., Jablonski, M., Jacak, B., Jacazio, N., Jacobs, P. M., Jadlovska, S., Jadlovsky, J., Jaelani, S., Jaffe, L., Jahnke, C., Jakubowska, M. J., Janik, M. A., Janson, T., Jercic, M., Jia, S., Jimenez, A. A. P., Jonas, F., Jowett, J. 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H., Yuan, S., Yuncu, A., Zaccolo, V., Zampolli, C., Zanone, F., Zardoshti, N., Zarochentsev, A., Závada, P., Zaviyalov, N., Zhalov, M., Zhang, B., Zhang, L., Zhang, M., Zhang, S., Zhang, X., Zhang, Y., Zhang, Z., Zhao, M., Zherebchevskii, V., Zhi, Y., Zhou, D., Zhou, Y., Zhu, J., Zhu, Y., Zugravel, S. C., and Zurlo, N.
Published: 2024
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38. The ALICE experiment: a journey through QCD

Author: Acharya, S., Adamová, D., Adler, A., Aglieri Rinella, G., Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S. U., Ahuja, I., Akindinov, A., Al-Turany, M., Aleksandrov, D., Alessandro, B., Alfanda, H. M., Alfaro Molina, R., Ali, B., Alici, A., Alizadehvandchali, N., Alkin, A., Alme, J., Alocco, G., Alt, T., Altsybeev, I., Alvarado, J. R., Anaam, M. N., Andrei, C., Andronic, A., Anguelov, V., Antinori, F., Antonioli, P., Apadula, N., Aphecetche, L., Appelshäuser, H., Arata, C., Arcelli, S., Aresti, M., Arnaldi, R., Arsene, I. C., Arslandok, M., Augustinus, A., Averbeck, R., Azmi, M. D., Badalà, A., Bae, J., Baek, Y. W., Bai, X., Bailhache, R., Bailung, Y., Bala, R., Balbino, A., Baldisseri, A., Balis, B., Banerjee, D., Banoo, Z., Barbera, R., Barile, F., Barioglio, L., Barlou, M., Barnaföldi, G. G., Barnby, L. S., Barret, V., Barreto, L., Bartels, C., Barth, K., Bartsch, E., Bastid, N., Basu, S., Batigne, G., Battistini, D., Batyunya, B., Bauri, D., Bazo Alba, J. L., Bearden, I. G., Beattie, C., Becht, P., Behera, D., Belikov, I., Bell Hechavarria, A. D. C., Bellini, F., Bellwied, R., Belokurova, S., Belyaev, V., Bencedi, G., Beole, S., Bercuci, A., Berdnikov, Y., Berdnikova, A., Bergmann, L., Besoiu, M. G., Betev, L., Bhaduri, P. P., Bhasin, A., Bhat, M. A., Bhattacharjee, B., Bianchi, L., Bianchi, N., Bielčík, J., Bielčíková, J., Biernat, J., Bigot, A. P., Bilandzic, A., Biro, G., Biswas, S., Bize, N., Blair, J. T., Blau, D., Blidaru, M. B., Bluhme, N., Blume, C., Boca, G., Bock, F., Bodova, T., Bogdanov, A., Boi, S., Bok, J., Boldizsár, L., Bolozdynya, A., Bombara, M., Bond, P. M., Bonomi, G., Borel, H., Borissov, A., Borquez Carcamo, A. G., Bossi, H., Botta, E., Bouziani, Y. E. M., Bratrud, L., Braun-Munzinger, P., Bregant, M., Broz, M., Bruno, G. E., Buckland, M. D., Budnikov, D., Buesching, H., Bufalino, S., Bugnon, O., Buhler, P., Buthelezi, Z., Bysiak, S. A., Cai, M., Caines, H., Caliva, A., Calvo Villar, E., Camacho, J. M. M., Camerini, P., Canedo, F. D. M., Cantway, S. L., Carabas, M., Carballo, A. A., Carnesecchi, F., Caron, R., Carvalho, L. A. D., Castillo Castellanos, J., Castro, A. J., Catalano, F., Ceballos Sanchez, C., Chakaberia, I., Chakraborty, P., Chandra, S., Chapeland, S., Chartier, M., Chattopadhyay, S., Chattopadhyay, S., Cheng, T., Cheshkov, C., Cheynis, B., Chibante Barroso, V., Chinellato, D. D., Chizzali, E. S., Cho, J., Cho, S., Chochula, P., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Ciacco, M., Cicalo, C., Cindolo, F., Ciupek, M. R., Clai, G., Colamaria, F., Colburn, J. S., Colella, D., Colocci, M., Concas, M., Conesa Balbastre, G., Conesa del Valle, Z., Contin, G., Contreras, J. G., Coquet, M. L., Cormier, T. M., Cortese, P., Cosentino, M. R., Costa, F., Costanza, S., Cot, C., Crkovská, J., Crochet, P., Cruz-Torres, R., Cuautle, E., Cui, P., Dainese, A., Damas, F. P. A., Danisch, M. C., Danu, A., Das, D., Das, P., Das, P., Das, S., Dash, A. R., Dash, S., De Caro, A., de Cataldo, G., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Martin, C., De Pasquale, S., Deb, S., Debski, R. J., Deja, K. R., Del Grande, R., Dello Stritto, L., Deng, W., Dhankher, P., Di Bari, D., Di Mauro, A., Diab, B., Diaz, R. A., Dietel, T., Ding, Y., Divià, R., Dixit, D. U., Djuvsland, Ø., Dmitrieva, U., Dobrin, A., Dönigus, B., Dubinski, J. M., Dubla, A., Dudi, S., Dupieux, P., Durkac, M., Dzalaiova, N., Eder, T. M., Ehlers, R. J., Eikeland, V. N., Eisenhut, F., Elia, D., Erazmus, B., Ercolessi, F., Erhardt, F., Ersdal, M. R., Espagnon, B., Eulisse, G., Evans, D., Evdokimov, S., Fabbietti, L., Faggin, M., Faivre, J., Fan, F., Fan, W., Fantoni, A., Fasel, M., Fecchio, P., Feliciello, A., Feofilov, G., Fernández Téllez, A., Ferrandi, L., Ferrer, M. B., Ferrero, A., Ferrero, C., Ferretti, A., Feuillard, V. J. G., Filova, V., Finogeev, D., Fionda, F. M., Flor, F., Flores, A. N., Foertsch, S., Fokin, I., Fokin, S., Fragiacomo, E., Frajna, E., Fuchs, U., Funicello, N., Furget, C., Furs, A., Fusayasu, T., Gaardhøje, J. J., Gagliardi, M., Gago, A. M., Gallio, M., Galvan, C. D., Gangadharan, D. R., Ganoti, P., Garabatos, C., García Chávez, T., Garcia-Solis, E., Garg, K., Gargiulo, C., Garner, K., Gasik, P., Gauger, E. F., Gautam, A., Gay Ducati, M. B., Germain, M., Ghosh, C., Giacalone, M., Giubellino, P., Giubilato, P., Glaenzer, A. M. C., Glässel, P., Glimos, E., Goh, D. J. Q., Gonzalez, V., González-Trueba, L. H., Gorgon, M., Gotovac, S., Grabski, V., Graczykowski, L. K., Grecka, E., Grelli, A., Grigoras, C., Grigoriev, V., Grigoryan, S., Grosa, F., Grosse-Oetringhaus, J. F., Grosso, R., Grund, D., Guardiano, G. G., Guernane, R., Guilbaud, M., Gulbrandsen, K., Gündem, T., Gunji, T., Guo, W., Gupta, A., Gupta, R., Gyulai, L., Habib, M. K., Hadjidakis, C., Haider, F. U., Hamagaki, H., Hamdi, A., Hamid, M., Han, Y., Hannigan, R., Haque, M. R., Harris, J. 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S., Romanenko, G., Ronchetti, F., Rosano, A., Rosas, E. D., Rossi, A., Roy, A., Roy, S., Rubini, N., Ruggiano, D., Rui, R., Rumyantsev, B., Russek, P. G., Russo, R., Rustamov, A., Ryabinkin, E., Ryabov, Y., Rybicki, A., Rytkonen, H., Rzesa, W., Saarimaki, O. A. M., Sadek, R., Sadhu, S., Sadovsky, S., Saetre, J., Šafařík, K., Saha, S. K., Saha, S., Sahoo, B., Sahoo, R., Sahoo, S., Sahu, D., Sahu, P. K., Saini, J., Sajdakova, K., Sakai, S., Salvan, M. P., Sambyal, S., Sanna, I., Saramela, T. B., Sarkar, D., Sarkar, N., Sarma, P., Sarritzu, V., Sarti, V. M., Sas, M. H. P., Schambach, J., Scheid, H. S., Schiaua, C., Schicker, R., Schmah, A., Schmidt, C., Schmidt, H. R., Schmidt, M. O., Schmidt, M., Schmidt, N. V., Schmier, A. R., Schotter, R., Schröter, A., Schukraft, J., Schwarz, K., Schweda, K., Scioli, G., Scomparin, E., Seger, J. E., Sekiguchi, Y., Sekihata, D., Selyuzhenkov, I., Senyukov, S., Seo, J. J., Serebryakov, D., Šerkšnytė, L., Sevcenco, A., Shaba, T. J., Shabetai, A., Shahoyan, R., Shangaraev, A., Sharma, A., Sharma, B., Sharma, D., Sharma, H., Sharma, M., Sharma, S., Sharma, S., Sharma, U., Shatat, A., Sheibani, O., Shigaki, K., Shimomura, M., Shin, J., Shirinkin, S., Shou, Q., Sibiriak, Y., Siddhanta, S., Siemiarczuk, T., Silva, T. F., Silvermyr, D., Simantathammakul, T., Simeonov, R., Singh, B., Singh, B., Singh, R., Singh, R., Singh, R., Singh, S., Singh, V. K., Singhal, V., Sinha, T., Sitar, B., Sitta, M., Skaali, T. B., Skorodumovs, G., Slupecki, M., Smirnov, N., Snellings, R. J. M., Solheim, E. H., Song, J., Songmoolnak, A., Soramel, F., Sorensen, S. P., Spijkers, R., Sputowska, I., Staa, J., Stachel, J., Stan, I., Steffanic, P. J., Stiefelmaier, S. F., Stocco, D., Storehaug, I., Stratmann, P., Strazzi, S., Stylianidis, C. P., Suaide, A. A. P., Suire, C., Sukhanov, M., Suljic, M., Sultanov, R., Sumberia, V., Sumowidagdo, S., Swain, S., Szarka, I., Taghavi, S. F., Taillepied, G., Takahashi, J., Tambave, G. 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G., Vande Vyvre, P., Varga, D., Varga, Z., Vasileiou, M., Vasiliev, A., Vázquez Doce, O., Vazquez Rueda, O., Vechernin, V., Vercellin, E., Vergara Limón, S., Vermunt, L., Vértesi, R., Verweij, M., Vickovic, L., Vilakazi, Z., Villalobos Baillie, O., Vino, G., Vinogradov, A., Virgili, T., Vislavicius, V., Vodopyanov, A., Volkel, B., Völkl, M. A., Voloshin, K., Voloshin, S. A., Volpe, G., von Haller, B., Vorobyev, I., Vozniuk, N., Vrláková, J., Wang, C., Wang, D., Wang, Y., Weber, M., Wegrzynek, A., Weiglhofer, F. T., Wenzel, S. C., Wessels, J. P., Wiechula, J., Wikne, J., Wilk, G., Wilkinson, J., Willems, G. A., Windelband, B., Winn, M., Wright, J. R., Wu, W., Wu, Y., Xu, R., Yadav, A., Yadav, A. K., Yalcin, S., Yamaguchi, Y., Yang, S., Yano, S., Yin, Z., Yoo, I.-K., Yoon, J. H., Yuan, S., Yuncu, A., Zaccolo, V., Zampolli, C., Zanone, F., Zardoshti, N., Zarochentsev, A., Závada, P., Zaviyalov, N., Zhalov, M., Zhang, B., Zhang, L., Zhang, S., Zhang, X., Zhang, Y., Zhang, Z., Zhao, M., Zherebchevskii, V., Zhi, Y., Zhou, D., Zhou, Y., Zhu, J., Zhu, Y., Zugravel, S. C., and Zurlo, N.
Published: 2024
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39. A Likelihood Ratio Approach for Utilizing Case‐Control Data in the Clinical Classification of Rare Sequence Variants: Application to BRCA1 and BRCA2

Author: Zanti, Maria, O′Mahony, Denise G, Parsons, Michael T, Li, Hongyan, Dennis, Joe, Aittomäkkiki, Kristiina, Andrulis, Irene L, Anton-Culver, Hoda, Aronson, Kristan J, Augustinsson, Annelie, Becher, Heiko, Bojesen, Stig E, Bolla, Manjeet K, Brenner, Hermann, Brown, Melissa A, Buys, Saundra S, Canzian, Federico, Caputo, Sandrine M, Castelao, Jose E, Chang-Claude, Jenny, Collaborators, GC-HBOC study, Czene, Kamila, Daly, Mary B, De Nicolo, Arcangela, Devilee, Peter, Dörk, Thilo, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Engel, Christoph, Evans, D Gareth, Fasching, Peter A, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, Gentry-Maharaj, Aleksandra, Giele, Willemina RR Geurts-, Giles, Graham G, Glendon, Gord, Goldberg, Mark S, Garcia, Encarna B Gómez, Güendert, Melanie, Guénel, Pascal, Hahnen, Eric, Haiman, Christopher A, Hall, Per, Hamann, Ute, Harkness, Elaine F, Hogervorst, Frans BL, Hollestelle, Antoinette, Hoppe, Reiner, Hopper, John L, Houdayer, Claude, Houlston, Richard S, Howell, Anthony, Investigators, ABCTB, Jakimovska, Milena, Jakubowska, Anna, Jernström, Helena, John, Esther M, Kaaks, Rudolf, Kitahara, Cari M, Koutros, Stella, Kraft, Peter, Kristensen, Vessela N, Lacey, James V, Lambrechts, Diether, Léoné, Melanie, Lindblom, Annika, Lubiński, Jan, Lush, Michael, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Martinez, Maria Elena, Menon, Usha, Milne, Roger L, Monteiro, Alvaro N, Murphy, Rachel A, Neuhausen, Susan L, Nevanlinna, Heli, Newman, William G, Offit, Kenneth, Park, Sue K, James, Paul, Peterlongo, Paolo, Peto, Julian, Plaseska-Karanfilska, Dijana, Punie, Kevin, Radice, Paolo, Rashid, Muhammad U, Rennert, Gad, Romero, Atocha, Rosenberg, Efraim H, Saloustros, Emmanouil, Sandler, Dale P, Schmidt, Marjanka K, Schmutzler, Rita K, and Shu, Xiao-Ou
Subjects: Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Biotechnology, Genetic Testing, Prevention, Cancer, Human Genome, Women's Health, Breast Cancer, 2.1 Biological and endogenous factors, Good Health and Well Being, Humans, Case-Control Studies, BRCA2 Protein, Genetic Predisposition to Disease, Female, BRCA1 Protein, Breast Neoplasms, Likelihood Functions, Genetic Variation, Penetrance, GC-HBOC study Collaborators, ABCTB Investigators, ACMG/AMP, BRCA, PS4, VUS, case-control, likelihood ratio, variant classification, Clinical Sciences, Genetics & Heredity, Clinical sciences
Abstract: A large number of variants identified through clinical genetic testing in disease susceptibility genes, are of uncertain significance (VUS). Following the recommendations of the American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP), the frequency in case-control datasets (PS4 criterion), can inform their interpretation. We present a novel case-control likelihood ratio-based method that incorporates gene-specific age-related penetrance. We demonstrate the utility of this method in the analysis of simulated and real datasets. In the analyses of simulated data, the likelihood ratio method was more powerful compared to other methods. Likelihood ratios were calculated for a case-control dataset of BRCA1 and BRCA2 variants from the Breast Cancer Association Consortium (BCAC), and compared with logistic regression results. A larger number of variants reached evidence in favor of pathogenicity, and a substantial number of variants had evidence against pathogenicity - findings that would not have been reached using other case-control analysis methods. Our novel method provides greater power to classify rare variants compared to classical case-control methods. As an initiative from the ENIGMA Analytical Working Group, we provide user-friendly scripts and pre-formatted excel calculators for implementation of the method for rare variants in BRCA1, BRCA2 and other high-risk genes with known penetrance.
Published: 2023

40. Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer‐specific survival

Author: Morra, Anna, Schreurs, Maartje AC, Andrulis, Irene L, Anton‐Culver, Hoda, Augustinsson, Annelie, Beckmann, Matthias W, Behrens, Sabine, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Broeks, Annegien, Buys, Saundra S, Camp, Nicola J, Castelao, Jose E, Cessna, Melissa H, Chang‐Claude, Jenny, Chung, Wendy K, Sahlberg, Kristine K, Børresen‐Dale, Anne‐Lise, Gram, Inger Torhild, Olsen, Karina Standahl, Engebråten, Olav, Naume, Bjørn, Geisler, Jürgen, OSBREAC, Alnæs, Grethe I Grenaker, Colonna, Sarah V, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Dennis, Joe, Devilee, Peter, Dörk, Thilo, Dunning, Alison M, Dwek, Miriam, Easton, Douglas F, Eccles, Diana M, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Fehm, Tanja N, Figueroa, Jonine D, Flyger, Henrik, Gabrielson, Marike, Gago‐Dominguez, Manuela, García‐Closas, Montserrat, García‐Sáenz, José A, Genkinger, Jeanine, Grassmann, Felix, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A, Hamann, Ute, Harrington, Patricia A, Hartikainen, Jaana M, Hoppe, Reiner, Hopper, John L, Houlston, Richard S, Howell, Anthony, Clarke, Christine, Marsh, Deborah, Scott, Rodney, Baxter, Robert, Yip, Desmond, Carpenter, Jane, Davis, Alison, Pathmanathan, Nirmala, Simpson, Peter, Graham, J Dinny, Sachchithananthan, Mythily, Amor, David, Andrews, Lesley, Antill, Yoland, Balleine, Rosemary, Beesley, Jonathan, Bennett, Ian, Bogwitz, Michael, Botes, Leon, Brennan, Meagan, Brown, Melissa, Buckley, Michael, Burke, Jo, Butow, Phyllis, Caldon, Liz, Campbell, Ian, Cao, Michelle, Chakrabarti, Anannya, Chauhan, Deepa, Chauhan, Manisha, Chenevix‐Trench, Georgia, Christian, Alice, Cohen, Paul, Colley, Alison, Crook, Ashley, Cui, James, Courtney, Eliza, Cummings, Margaret, and Dawson, Sarah‐Jane
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Women's Health, Breast Cancer, Clinical Research, Prevention, Cancer, Female, Humans, Breast Neoplasms, Checkpoint Kinase 2, Genetic Predisposition to Disease, Germ-Line Mutation, Heterozygote, Proportional Hazards Models, CHEK2 c.1100delC germline genetic variant, contralateral breast cancer risk, radiotherapy, survival, systemic treatment, NBCS Collaborators, ABCTB Investigators, kConFab Investigators, Biochemistry and Cell Biology, Oncology and carcinogenesis
Abstract: BackgroundBreast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers.AimTo assessed the associations of CHEK2 c.1100delC, radiotherapy, and systemic treatment with CBC risk and BCSS.MethodsAnalyses were based on 82,701 women diagnosed with a first primary invasive BC including 963 CHEK2 c.1100delC carriers; median follow-up was 9.1 years. Differential associations with treatment by CHEK2 c.1100delC status were tested by including interaction terms in a multivariable Cox regression model. A multi-state model was used for further insight into the relation between CHEK2 c.1100delC status, treatment, CBC risk and death.ResultsThere was no evidence for differential associations of therapy with CBC risk by CHEK2 c.1100delC status. The strongest association with reduced CBC risk was observed for the combination of chemotherapy and endocrine therapy [HR (95% CI): 0.66 (0.55-0.78)]. No association was observed with radiotherapy. Results from the multi-state model showed shorter BCSS for CHEK2 c.1100delC carriers versus non-carriers also after accounting for CBC occurrence [HR (95% CI): 1.30 (1.09-1.56)].ConclusionSystemic therapy was associated with reduced CBC risk irrespective of CHEK2 c.1100delC status. Moreover, CHEK2 c.1100delC carriers had shorter BCSS, which appears not to be fully explained by their CBC risk.
Published: 2023

41. Transit timing variation analysis of the low-mass brown dwarf KELT-1 b

Author: Baştürk, Ö., Southworth, J., Yalçınkaya, S., Mancini, L., Esmer, E. M., Tekin, M., Tezcan, F., Evans, D. F., Tezcan, C. T., Bruni, I., and Yeşilyaprak, C.
Subjects: Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: We investigate whether there is a variation in the orbital period of the short-period brown dwarf-mass KELT-1\,b, which is one of the best candidates to observe orbital decay. We obtain 19 high-precision transit light curves of the target using six different telescopes. We add all precise and complete transit light curves from open databases and the literature, as well as the available TESS observations from sectors 17 and 57, to form a transit timing variation (TTV) diagram spanning more than 10 years of observations. The analysis of the TTV diagram, however, is inconclusive in terms of a secular or periodic variation, hinting that the system might have synchronized. We update the transit ephemeris and determine an informative lower limit for the reduced tidal quality parameter of its host star of Q$_{\star}^{\prime} > (8.5 \pm 3.9) \times 10^{6}$ assuming that the stellar rotation is not yet synchronised. Using our new photometric observations, published light curves, the TESS data, archival radial velocities and broadband magnitudes, we also update the measured parameters of the system. Our results are in good agreement with those found in previous analyses., Comment: Accepted for publication by the MNRAS on 2023/01/16
Published: 2023
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42. Cancer in Neurofibromatosis Type 1

Author: Evans, D. Gareth, Wright, Emma Burkitt, Lee, Alexander, and Rauen, Katherine A., editor
Published: 2024
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43. Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival

Author: Lopes Cardozo, Josephine MN, Andrulis, Irene L, Bojesen, Stig E, Dörk, Thilo, Eccles, Diana M, Fasching, Peter A, Hooning, Maartje J, Keeman, Renske, Nevanlinna, Heli, Rutgers, Emiel JT, Easton, Douglas F, Hall, Per, Pharoah, Paul DP, van 't Veer, Laura J, Schmidt, Marjanka K, Ahearn, Thomas U, Anton-Culver, Hoda, Arndt, Volker, Auer, Paul L, Augustinsson, Annelie, Beane Freeman, Laura E, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Bolla, Manjeet K, Bonanni, Bernardo, Boyle, Terry, Brenner, Hermann, Brucker, Sara Y, Brüning, Thomas, Burwinkel, Barbara, Buys, Saundra S, Camp, Nicola J, Canzian, Federico, Cardoso, Fatima, Castelao, Jose E, Cessna, Melissa H, Chan, Tsun L, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Choi, Ji-Yeob, Colonna, Sarah V, Copson, Ellen, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Dennis, Joe, Devilee, Peter, Drukker, Caroline A, Dunning, Alison M, Dwek, Miriam, Eliassen, A Heather, Engel, Christoph, Evans, D Gareth, Figueroa, Jonine D, Fletcher, Olivia, Flyger, Henrik, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, Genkinger, Jeanine, Giles, Graham G, González-Neira, Anna, Guénel, Pascal, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hamann, Ute, Hartman, Mikael, Heemskerk-Gerritsen, Bernadette AM, Hein, Alexander, Ho, Weang-Kee, Hoppe, Reiner, Hopper, John L, Houlston, Richard S, Howell, Anthony, Hunter, David J, Ito, Hidemi, Jakubowska, Anna, Jernström, Helena, John, Esther M, Johnson, Nichola, Jones, Michael E, Joseph, Vijai, Kaaks, Rudolf, Kang, Daehee, Kim, Sung-Won, Kitahara, Cari M, Koppert, Linetta B, Kosma, Veli-Matti, Kraft, Peter, Kristensen, Vessela N, Kubelka-Sabit, Katerina, and Koutros, Stella
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Breast Cancer, Cancer, Good Health and Well Being, Female, Humans, Breast Neoplasms, Risk Factors, Prognosis, Proportional Hazards Models, Breast, Breast Cancer Association Consortium and MINDACT Collaborators, Clinical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract: PurposeA polygenic risk score (PRS) consisting of 313 common genetic variants (PRS313) is associated with risk of breast cancer and contralateral breast cancer. This study aimed to evaluate the association of the PRS313 with clinicopathologic characteristics of, and survival following, breast cancer.MethodsWomen with invasive breast cancer were included, 98,397 of European ancestry and 12,920 of Asian ancestry, from the Breast Cancer Association Consortium (BCAC), and 683 women from the European MINDACT trial. Associations between PRS313 and clinicopathologic characteristics, including the 70-gene signature for MINDACT, were evaluated using logistic regression analyses. Associations of PRS313 (continuous, per standard deviation) with overall survival (OS) and breast cancer-specific survival (BCSS) were evaluated with Cox regression, adjusted for clinicopathologic characteristics and treatment.ResultsThe PRS313 was associated with more favorable tumor characteristics. In BCAC, increasing PRS313 was associated with lower grade, hormone receptor-positive status, and smaller tumor size. In MINDACT, PRS313 was associated with a low risk 70-gene signature. In European women from BCAC, higher PRS313 was associated with better OS and BCSS: hazard ratio (HR) 0.96 (95% CI, 0.94 to 0.97) and 0.96 (95% CI, 0.94 to 0.98), but the association disappeared after adjustment for clinicopathologic characteristics (and treatment): OS HR, 1.01 (95% CI, 0.98 to 1.05) and BCSS HR, 1.02 (95% CI, 0.98 to 1.07). The results in MINDACT and Asian women from BCAC were consistent.ConclusionAn increased PRS313 is associated with favorable tumor characteristics, but is not independently associated with prognosis. Thus, PRS313 has no role in the clinical management of primary breast cancer at the time of diagnosis. Nevertheless, breast cancer mortality rates will be higher for women with higher PRS313 as increasing PRS313 is associated with an increased risk of disease. This information is crucial for modeling effective stratified screening programs.
Published: 2023

44. Gaia Data Release 3: Gaia scan-angle dependent signals and spurious periods

Author: Holl, B., Fabricius, C., Portell, J., Lindegren, L., Panuzzo, P., Bernet, M., Castañeda, J., de Fombelle, G. Jevardat, Audard, M., Ducourant, C., Harrison, D. L., Evans, D. W., Busso, G., Sozzetti, A., Gosset, E., Arenou, F., De Angeli, F., Riello, M., Eyer, L., Rimoldini, L., Gavras, P., Mowlavi, N., Nienartowicz, K., Lecoeur-Taïbi, I., García-Lario, P., and Pourbaix, D.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract: Context: Gaia DR3 time series data may contain spurious signals related to the time-dependent scan angle. Aims: We aim to explain the origin of scan-angle dependent signals and how they can lead to spurious periods, provide statistics to identify them in the data, and suggest how to deal with them in Gaia DR3 data and in future releases. Methods: Using real Gaia data, alongside numerical and analytical models, we visualise and explain the features observed in the data. Results: We demonstrated with Gaia data that source structure (multiplicity or extendedness) or pollution from close-by bright objects can cause biases in the image parameter determination from which photometric, astrometric and (indirectly) radial velocity time series are derived. These biases are a function of the time-dependent scan direction of the instrument and thus can introduce scan-angle dependent signals, which in turn can result in specific spurious periodic signals. Numerical simulations qualitatively reproduce the general structure observed in the spurious period and spatial distribution of photometry and astrometry. A variety of statistics allows for identification of affected sources. Conclusions: The origin of the scan-angle dependent signals and subsequent spurious periods is well-understood and is in majority caused by fixed-orientation optical pairs with separation <0.5" (amongst which binaries with P>>5y) and (cores of) distant galaxies. Though the majority of sources with affected derived parameters have been filtered out from the Gaia archive, there remain Gaia DR3 data that should be treated with care (e.g. gaia_source was untouched). Finally, the various statistics discussed in the paper can not only be used to identify and filter affected sources, but alternatively reveal new information about them not available through other means, especially in terms of binarity on sub-arcsecond scale., Comment: 60 Figures, 2 Tables, A&A accepted, added overlooked reference to https://ui.adsabs.harvard.edu/abs/2022arXiv221005003C/abstract
Published: 2022
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45. Structural Origin of Recovered Ferroelectricity in BaTiO$_3$ Nanoparticles

Author: Zhang, H., Liu, S., Ghose, S., Ravel, B., Idehenre, I. U., Barnakov, Y. A., Basun, S. A., Evans, D. R., and Tyson, T. A.
Subjects: Condensed Matter - Materials Science
Abstract: Nanoscale BaTiO3 particles (approximately 10 nm) prepared by ball-milling a mixture of oleic acid and heptane have been reported to have an electric polarization several times larger than that for bulk BaTiO3. In this work, detailed local, intermediate, and long-range structural studies are combined with spectroscopic measurements to develop a model structure of these materials. The X-ray spectroscopic measurements reveal large Ti off-centering as the key factor producing the large spontaneous polarization in the nanoparticles. Temperature-dependent lattice parameter changes reveal the sharpening of the structural phase transitions in these BaTiO3 nanoparticles compared to the pure nanoparticle systems. Sharp crystalline-type peaks in the barium oleate Raman spectra suggest that this component in the composite core-shell matrix, a product of mechanochemical synthesis, stabilizes an enhanced polar structural phase of the BaTiO3 core nanoparticles., Comment: 5 figures in main text. 1 table and 4 figures in supplementary document
Published: 2022

46. The effect of variable labels on deep learning models trained to predict breast density

Author: Squires, Steven, Harkness, Elaine F., Evans, D. Gareth, and Astley, Susan M.
Subjects: Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract: Purpose: High breast density is associated with reduced efficacy of mammographic screening and increased risk of developing breast cancer. Accurate and reliable automated density estimates can be used for direct risk prediction and passing density related information to further predictive models. Expert reader assessments of density show a strong relationship to cancer risk but also inter-reader variation. The effect of label variability on model performance is important when considering how to utilise automated methods for both research and clinical purposes. Methods: We utilise subsets of images with density labels to train a deep transfer learning model which is used to assess how label variability affects the mapping from representation to prediction. We then create two end-to-end deep learning models which allow us to investigate the effect of label variability on the model representation formed. Results: We show that the trained mappings from representations to labels are altered considerably by the variability of reader scores. Training on labels with distribution variation removed causes the Spearman rank correlation coefficients to rise from $0.751\pm0.002$ to either $0.815\pm0.006$ when averaging across readers or $0.844\pm0.002$ when averaging across images. However, when we train different models to investigate the representation effect we see little difference, with Spearman rank correlation coefficients of $0.846\pm0.006$ and $0.850\pm0.006$ showing no statistically significant difference in the quality of the model representation with regard to density prediction. Conclusions: We show that the mapping between representation and mammographic density prediction is significantly affected by label variability. However, the effect of the label variability on the model representation is limited.
Published: 2022

47. Gaia Data Release 3: Summary of the content and survey properties

Author: Gaia Collaboration, Vallenari, A., Brown, A. G. A., Prusti, T., de Bruijne, J. H. J., Arenou, F., Babusiaux, C., Biermann, M., Creevey, O. L., Ducourant, C., Evans, D. W., Eyer, L., Guerra, R., Hutton, A., Jordi, C., Klioner, S. A., Lammers, U. L., Lindegren, L., Luri, X., Mignard, F., Panem, C., Pourbaix, D., Randich, S., Sartoretti, P., Soubiran, C., Tanga, P., Walton, N. A., Bailer-Jones, C. A. L., Bastian, U., Drimmel, R., Jansen, F., Katz, D., Lattanzi, M. G., van Leeuwen, F., Bakker, J., Cacciari, C., Castañeda, J., De Angeli, F., Fabricius, C., Fouesneau, M., Frémat, Y., Galluccio, L., Guerrier, A., Heiter, U., Masana, E., Messineo, R., Mowlavi, N., Nicolas, C., Nienartowicz, K., Pailler, F., Panuzzo, P., Riclet, F., Roux, W., Seabroke, G. M., Sordoørcit, R., Thévenin, F., Gracia-Abril, G., Portell, J., Teyssier, D., Altmann, M., Andrae, R., Audard, M., Bellas-Velidis, I., Benson, K., Berthier, J., Blomme, R., Burgess, P. W., Busonero, D., Busso, G., Cánovas, H., Carry, B., Cellino, A., Cheek, N., Clementini, G., Damerdji, Y., Davidson, M., de Teodoro, P., Campos, M. Nuñez, Delchambre, L., Dell'Oro, A., Esquej, P., Fernández-Hernández, J., Fraile, E., Garabato, D., García-Lario, P., Gosset, E., Haigron, R., Halbwachs, J. -L., Hambly, N. C., Harrison, D. L., Hernández, J., Hestroffer, D., Hodgkin, S. T., Holl, B., Janßen, K., de Fombelle, G. Jevardat, Jordan, S., Krone-Martins, A., Lanzafame, A. C., Löffler, W., Marchal, O., Marrese, P. M., Moitinho, A., Muinonen, K., Osborne, P., Pancino, E., Pauwels, T., Recio-Blanco, A., Reylé, C., Riello, M., Rimoldini, L., Roegiers, T., Rybizki, J., Sarro, L. M., Siopis, C., Smith, M., Sozzetti, A., Utrilla, E., van Leeuwen, M., Abbas, U., Ábrahám, P., Aramburu, A. Abreu, Aerts, C., Aguado, J. J., Ajaj, M., Aldea-Montero, F., Altavilla, G., Álvarez, M. A., Alves, J., Anders, F., Anderson, R. I., Varela, E. Anglada, Antoja, T., Baines, D., Baker, S. G., Balaguer-Núñez, L., Balbinot, E., Balog, Z., Barache, C., Barbato, D., Barros, M., Barstow, M. A., Bartolomé, S., Bassilana, J. -L., Bauchet, N., Becciani, U., Bellazzini, M., Berihuete, A., Bernet, M., Bertone, S., Bianchi, L., Binnenfeld, A., Blanco-Cuaresma, S., Blazere, A., Boch, T., Bombrun, A., Bossini, D., Bouquillon, S., Bragaglia, A., Bramante, L., Breedt, E., Bressan, A., Brouillet, N., Brugaletta, E., Bucciarelli, B., Burlacu, A., Butkevich, A. G., Buzzi, R., Caffau, E., Cancelliere, R., Cantat-Gaudin, T., Carballo, R., Carlucci, T., Carnerero, M. I., Carrasco, J. M., Casamiquela, L., Castellani, M., Castro-Ginard, A., Chaoul, L., Charlot, P., Chemin, L., Chiaramida, V., Chiavassa, A., Chornay, N., Comoretto, G., Contursi, G., Cooper, W. J., Cornez, T., Cowell, S., Crifo, F., Cropper, M., Crosta, M., Crowley, C., Dafonte, C., Dapergolas, A., David, M., David, P., de Laverny, P., De Luise, F., De March, R., De Ridder, J., de Souza, R., de Torres, A., del Peloso, E. F., del Pozo, E., Delbo, M., Delgado, A., Delisle, J. -B., Demouchy, C., Dharmawardena, T. E., Di Matteo, P., Diakite, S., Diener, C., Distefano, E., Dolding, C., Edvardsson, B., Enke, H., Fabre, C., Fabrizio, M., Faigler, S., Fedorets, G., Fernique, P., Fienga, A., Figueras, F., Fournier, Y., Fouron, C., Fragkoudi, F., Gai, M., Garcia-Gutierrez, A., Garcia-Reinaldos, M., García-Torres, M., Garofalo, A., Gavel, A., Gavras, P., Gerlach, E., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Gomel, R., Gomez, A., González-Núñez, J., González-Santamaría, I., González-Vidal, J. J., Granvik, M., Guillout, P., Guiraud, J., Gutiérrez-Sánchez, R., Guy, L. P., Hatzidimitriou, D., Hauser, M., Haywood, M., Helmer, A., Helmi, A., Sarmiento, M. H., Hidalgo, S. L., Hilger, T., Hładczuk, N., Hobbs, D., Holland, G., Huckle, H. E., Jardine, K., Jasniewicz, G., Piccolo, A. Jean-Antoine, Jiménez-Arranz, Ó., Jorissen, A., Campillo, J. Juaristi, Julbe, F., Karbevska, L., Kervella, P., Khanna, S., Kontizas, M., Kordopatis, G., Korn, A. J., Kóspál, Á, Kostrzewa-Rutkowska, Z., Kruszyńska, K., Kun, M., Laizeau, P., Lambert, S., Lanza, A. F., Lasne, Y., Campion, J. -F. Le, Lebreton, Y., Lebzelter, T., Leccia, S., Leclerc, N., Lecoeur-Taibi, I., Liao, S., Licata, E. L., Lindstrøm, H. E. P., Lister, T. A., Livanou, E., Lobel, A., Lorca, A., Loup, C., Pardo, P. Madrero, Romeo, A. Magdaleno, Managau, S., Mann, R. G., Manteiga, M., Marchant, J. M., Marconi, M., Marcos, J., Santos, M. M. S. Marcos, Pina, D. Marín, Marinoni, S., Marocco, F., Marshall, D. J., Polo, L. Martin, Martín-Fleitas, J. M., Marton, G., Mary, N., Masip, A., Massari, D., Mastrobuono-Battisti, A., Mazeh, T., McMillan, P. J., Messina, S., Michalik, D., Millar, N. R., Mints, A., Molina, D., Molinaro, R., Molnár, L., Monari, G., Monguió, M., Montegriffo, P., Montero, A., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morris, D., Muraveva, T., Murphy, C. P., Musella, I., Nagy, Z., Noval, L., Ocaña, F., Ogden, A., Ordenovic, C., Osinde, J. O., Pagani, C., Pagano, I., Palaversa, L., Palicio, P. A., Pallas-Quintela, L., Panahi, A., Payne-Wardenaar, S., Esteller, X. Peñalosa, Penttilä, A., Pichon, B., Piersimoni, A. M., Pineau, F. -X., Plachy, E., Plum, G., Poggio, E., Prša, A., Pulone, L., Racero, E., Ragaini, S., Rainer, M., Raiteri, C. M., Rambaux, N., Ramos, P., Ramos-Lerate, M., Fiorentin, P. Re, Regibo, S., Richards, P. J., Diaz, C. Rios, Ripepi, V., Riva, A., Rix, H. -W., Rixon, G., Robichon, N., Robin, A. C., Robin, C., Roelens, M., Rogues, H. R. O., Rohrbasser, L., Romero-Gómez, M., Rowell, N., Royer, F., Mieres, D. Ruz, Rybicki, K. A., Sadowski, G., Núñez, A. Sáez, Sellés, A. Sagristà, Sahlmann, J., Salguero, E., Samaras, N., Gimenez, V. Sanchez, Sanna, N., Santoveña, R., Sarasso, M., Schultheis, M., Sciacca, E., Segol, M., Segovia, J. C., Ségransan, D., Semeux, D., Shahaf, S., Siddiqui, H. I., Siebert, A., Siltala, L., Silvelo, A., Slezak, E., Slezak, I., Smart, R. L., Snaith, O. N., Solano, E., Solitro, F., Souami, D., Souchay, J., Spagna, A., Spina, L., Spoto, F., Steele, I. A., Steidelmüller, H., Stephenson, C. A., Süveges, M., Surdej, J., Szabados, L., Szegedi-Elek, E., Taris, F., Taylo, M. B., Teixeira, R., Tolomei, L., Tonello, N., Torra, F., Torra, J., Elipe, G. Torralba, Trabucchi, M., Tsounis, A. T., Turon, C., Ulla, A., Unger, N., Vaillant, M. V., van Dillen, E., van Reeven, W., Vanel, O., Vecchiato, A., Viala, Y., Vicente, D., Voutsinas, S., Weiler, M., Wevers, T., Wyrzykowski, L., Yoldas, A., Yvard, P., Zhao, H., Zorec, J., Zucker, S., and Zwitter, T.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: We present the third data release of the European Space Agency's Gaia mission, GDR3. The GDR3 catalogue is the outcome of the processing of raw data collected with the Gaia instruments during the first 34 months of the mission by the Gaia Data Processing and Analysis Consortium. The GDR3 catalogue contains the same source list, celestial positions, proper motions, parallaxes, and broad band photometry in the G, G$_{BP}$, and G$_{RP}$ pass-bands already present in the Early Third Data Release. GDR3 introduces an impressive wealth of new data products. More than 33 million objects in the ranges $G_{rvs} < 14$ and $3100
Published: 2022
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48. Measurement of the Parity-Odd Angular Distribution of Gamma Rays From Polarized Neutron Capture on $^{35}$Cl

Author: Fomin, N., Alarcon, R., Alonzi, L., Askanazi, E., Baeßler, S., Balascuta, S., Barrón-Palos, L., Barzilov, A., Blyth, D., Bowman, J. D., Birge, N., Calarco, J. R., Chupp, T. E., Cianciolo, V., Coppola, C. E., Crawford, C. B., Craycraft, K., Evans, D., Fieseler, C., Frlež, E., Fry, J., Garishvili, I., Gericke, M. T. W., Gillis, R. C., Grammer, K. B., Greene, G. L., Hall, J., Hamblen, J., Hayes, C., Iverson, E. B., Kabir, M. L., Kucuker, S., Lauss, B., Mahurin, R., McCrea, M., Maldonado-Velázquez, M., Masuda, Y., Mei, J., Milburn, R., Mueller, P. E., Musgrave, M., Nann, H., Novikov, I., Parsons, D., Penttilä, S. I., Počanić, D., Ramirez-Morales, A., Root, M., Salas-Bacci, A., Santra, S., Schröder, S., Scott, E., Seo, P. -N., Sharapov, E. I., Simmons, F., Snow, W. M., Sprow, A., Stewart, J., Tang, E., Tang, Z., Tong, X., Turkoglu, D. J., Whitehead, R., and Wilburn, W. S.
Subjects: Nuclear Experiment, Nuclear Theory
Abstract: We report a measurement of two energy-weighted gamma cascade angular distributions from polarized slow neutron capture on the ${}^{35}$Cl nucleus, one parity-odd correlation proportional to $\vec{s_{n}} \cdot \vec{k_{\gamma}}$ and one parity-even correlation proportional to $\vec{s_{n}} \cdot \vec{k_{n}} \times \vec{k_{\gamma}}$. A parity violating asymmetry can appear in this reaction due to the weak nucleon-nucleon (NN) interaction which mixes opposite parity S and P-wave levels in the excited compound $^{36}$Cl nucleus formed upon slow neutron capture. If parity-violating (PV) and parity-conserving (PC) terms both exist, the measured differential cross section can be related to them via $\frac{d\sigma}{d\Omega}\propto1+A_{\gamma, PV}\cos\theta+A_{\gamma,PC}\sin\theta$. The PV and PC asymmetries for energy-weighted gamma cascade angular distributions for polarized slow neutron capture on $^{35}$Cl averaged over the neutron energies from 2.27~meV to 9.53~meV were measured to be $A_{\gamma,PV}=(-23.9\pm0.7)\times 10^{-6}$ and $A_{\gamma,PC}=(0.1\pm0.7)\times 10^{-6}$. These results are consistent with previous experimental results. Systematic errors were quantified and shown to be small compared to the statistical error. These asymmetries in the angular distributions of the gamma rays emitted from the capture of polarized neutrons in $^{35}$Cl were used to verify the operation and data analysis procedures for the NPDGamma experiment which measured the parity-odd asymmetry in the angular distribution of gammas from polarized slow neutron capture on protons.
Published: 2022
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49. A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

Author: Middha, Pooja, Wang, Xiaoliang, Behrens, Sabine, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J, Auer, Paul L, Augustinsson, Annelie, Baert, Thaïs, Freeman, Laura E Beane, Becher, Heiko, Beckmann, Matthias W, Benitez, Javier, Bojesen, Stig E, Brauch, Hiltrud, Brenner, Hermann, Brooks-Wilson, Angela, Campa, Daniele, Canzian, Federico, Carracedo, Angel, Castelao, Jose E, Chanock, Stephen J, Chenevix-Trench, Georgia, Cordina-Duverger, Emilie, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Dossus, Laure, Dugué, Pierre-Antoine, Eliassen, A Heather, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Figueroa, Jonine D, Fletcher, Olivia, Flyger, Henrik, Gabrielson, Marike, Gago-Dominguez, Manuela, Giles, Graham G, González-Neira, Anna, Grassmann, Felix, Grundy, Anne, Guénel, Pascal, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hankinson, Susan E, Harkness, Elaine F, Holleczek, Bernd, Hoppe, Reiner, Hopper, John L, Houlston, Richard S, Howell, Anthony, Hunter, David J, Ingvar, Christian, Isaksson, Karolin, Jernström, Helena, John, Esther M, Jones, Michael E, Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M, Ko, Yon-Dschun, Koutros, Stella, Kurian, Allison W, Lacey, James V, Lambrechts, Diether, Larson, Nicole L, Larsson, Susanna, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Shuai, Linet, Martha, Lissowska, Jolanta, Martinez, Maria Elena, Maurer, Tabea, Mulligan, Anna Marie, Mulot, Claire, Murphy, Rachel A, Newman, William G, Nielsen, Sune F, Nordestgaard, Børge G, Norman, Aaron, O’Brien, Katie M, Olson, Janet E, Patel, Alpa V, Prentice, Ross, Rees-Punia, Erika, Rennert, Gad, Rhenius, Valerie, Ruddy, Kathryn J, and Sandler, Dale P
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer Genomics, Human Genome, Estrogen, Cancer, Women's Health, Genetics, Prevention, Aging, Breast Cancer, 2.1 Biological and endogenous factors, Adult, Female, Humans, Gene-Environment Interaction, Genetic Predisposition to Disease, Breast Neoplasms, Bayes Theorem, Genome-Wide Association Study, Risk Factors, Polymorphism, Single Nucleotide, Case-Control Studies, Breast cancer, Gene-environment interactions, Genetic epidemiology, European ancestry, CTS Consortium, ABCTB Investigators, kConFab Investigators, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract: BackgroundGenome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.MethodsAnalyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs.ResultsAssuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability
Published: 2023

50. Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

Author: Mueller, Stefanie H, Lai, Alvina G, Valkovskaya, Maria, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Lush, Michael, Abu-Ful, Zomoruda, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Baert, Thais, Freeman, Laura E Beane, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Bonanni, Bernardo, Brenner, Hermann, Brucker, Sara Y, Buys, Saundra S, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Choi, Ji-Yeob, Chung, Wendy K, Colonna, Sarah V, Cornelissen, Sten, Couch, Fergus J, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dossus, Laure, Dwek, Miriam, Eccles, Diana M, Ekici, Arif B, Eliassen, A Heather, Engel, Christoph, Evans, D Gareth, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Gago-Dominguez, Manuela, Gao, Yu-Tang, García-Closas, Montserrat, García-Sáenz, José A, Genkinger, Jeanine, Gentry-Maharaj, Aleksandra, Grassmann, Felix, Guénel, Pascal, Gündert, Melanie, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Harkness, Elaine F, Harrington, Patricia A, Hartikainen, Jaana M, Hartman, Mikael, Hein, Alexander, Ho, Weang-Kee, Hooning, Maartje J, Hoppe, Reiner, Hopper, John L, Houlston, Richard S, Howell, Anthony, Hunter, David J, Huo, Dezheng, Ito, Hidemi, Iwasaki, Motoki, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jones, Michael E, Jung, Audrey, Kaaks, Rudolf, Kang, Daehee, Khusnutdinova, Elza K, Kim, Sung-Won, Kitahara, Cari M, Koutros, Stella, Kraft, Peter, Kristensen, Vessela N, Kubelka-Sabit, Katerina, Kurian, Allison W, Kwong, Ava, Lacey, James V, Lambrechts, Diether, and Le Marchand, Loic
Subjects: Breast Cancer, Genetics, Clinical Research, Cancer, Aetiology, 2.1 Biological and endogenous factors, Humans, Female, Breast Neoplasms, Genetic Predisposition to Disease, Black People, Genetic Testing, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Formins, Breast cancer susceptibility, Diverse ancestry, Rare variants, Gene regulation, Genome-wide association study, NBCS Collaborators, CTS Consortium, ABCTB Investigators, Clinical Sciences
Abstract: BackgroundLow-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.MethodsWe evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry.ResultsIn European ancestry samples, 14 genes were significantly associated (q
Published: 2023

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