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26 results on '"Evansky, Paul"'

3. Enriched housing differentially alters allostatic load and cardiopulmonary responses to wildfire-related smoke in male and female mice

Author

Fiamingo, Michelle, primary, Bailey, Aleah, additional, Toler, Sydnie, additional, Lee, Kaleb, additional, Oshiro, Wendy, additional, Yoo, Brendan, additional, Krantz, Todd, additional, Evansky, Paul, additional, Davies, David, additional, Gilmour, M. Ian, additional, Farraj, Aimen, additional, Jaspers, Ilona, additional, and Hazari, Mehdi S., additional

Published
2024
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12. Benchmark Dose Modeling Approaches for Volatile Organic Chemicals Using a Novel Air-Liquid Interface In Vitro Exposure System

Author

Speen, Adam M, primary, Murray, Jessica R, additional, Krantz, Quentin Todd, additional, Davies, David, additional, Evansky, Paul, additional, Harrill, Joshua A, additional, Everett, Logan J, additional, Bundy, Joseph L, additional, Dailey, Lisa A, additional, Hill, Jazzlyn, additional, Zander, Wyatt, additional, Carlsten, Elise, additional, Monsees, Michael, additional, Zavala, Jose, additional, and Higuchi, Mark A, additional

Published
2022
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19. Development and Application of an LC-MS/MS Method for the Detection of the Vinyl Chloride-Induced DNA Adduct N 2 ,3-Ethenoguanine in Tissues of Adult and Weanling Rats Following Exposure to [ 13 C 2 ]-VC

Author

Mutlu, Esra, Upton, Patricia B., Stout, Matthew D., Hatch, Gary, Winsett, Darrell, Evansky, Paul, Daye, Laura R., Collins, Leonard B., and Swenberg, James A.

Abstract

In the 1970s exposure to vinyl chloride (VC) was shown to cause liver angiosarcoma in VC workers. We have developed a new LC-MS/MS method for analyzing the promutagenic DNA adduct N2,3-ethenoguanine (εG) and have applied this to DNA from tissues of both adult and weanling rats exposed to 1100 ppm [13C2]-VC for 5 days or 1100 ppm VC for 1 day. This assay utilizes neutral thermal hydrolysis and an HPLC clean-up prior to quantitation by LC-MS/MS. The number of endogenous and exogenous εG adducts in DNA from tissues of adult rats exposed to [13C2]-VC for 5 days was 4.1±2.8 adducts/108 guanine of endogenous and 19.0±4.9 adducts/108 guanine of exogenous εG in liver, 8.4±2.8 adducts/108 guanine of endogenous and 7.4±0.5 adducts/108 guanine of exogenous εG in lung and 5.9±3.3 adducts/108 guanine of endogenous and 5.7±2.1 adducts/108 guanine of exogenous εG in kidney (n=4). Additionally, the data from weanling rats demonstrated higher numbers of exogenous εG, with ~4 fold higher amounts in liver DNA of weanlings (75.9±17.9 adducts/108 guanine) in comparison to adult rats and ~2 fold higher amounts in lung (15.8±3.6 adducts/108 guanine) and kidney (12.9±0.4 adducts/108 guanine) (n=8). The use of stable isotope labeled VC permitted accurate estimates of the half life of εG for the first time by comparing [13C2]-εG in adult rats with identically exposed animals killed 2, 4 or 8 weeks later. The half life of εG was found to be 150 days in liver and lung and 75 days in kidney, suggesting little or no active repair of this promutagenic adduct.

Published
2010
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20. Use of novel inhalation kinetic studies to refine physiologically-based pharmacokinetic models for ethanol in non-pregnant and pregnant rats

Author

Martin, Sheppard A., primary, Oshiro, Wendy M., additional, Evansky, Paul A., additional, Degn, Laura L., additional, Ledbetter, Allen D., additional, Ford, Jermaine, additional, Todd Krantz, Q., additional, LeFew, William R., additional, Beasley, Tracey E., additional, El-Masri, Hisham, additional, McLanahan, Eva D., additional, Boyes, William K., additional, and Bushnell, Philip J., additional

Published
2014
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22. EPA Research on Health Effects of Biofuels: Studies with inhaled ethanol in rats

Author

Bushnell, Philip, primary, Beasley, Tracey, additional, Boyes, William, additional, El-Masri, Hisham, additional, Evansky, Paul, additional, Ford, Jermaine, additional, Gilbert, Mary, additional, Herr, David, additional, LeFew, William, additional, Martin, Sheppard, additional, McDaniel, Kathy, additional, McLanahan, Eva, additional, MacMillan, Denise, additional, Moser, Ginger, additional, and Oshiro, Wendy, additional

Published
2011
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23. Development and Application of an LC-MS/MS Method for the Detection of the Vinyl Chloride-Induced DNA Adduct N2,3-Ethenoguanine in Tissues of Adult and Weanling Rats Following Exposure to [13C2]-VC

Author

Mutlu, Esra, primary, Collins, Leonard B., additional, Stout, Matthew D., additional, Upton, Patricia B., additional, Daye, Laura R., additional, Winsett, Darrell, additional, Hatch, Gary, additional, Evansky, Paul, additional, and Swenberg, James A., additional

Published
2010
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26. Depleted housing elicits cardiopulmonary dysfunction after a single flaming eucalyptus wildfire smoke exposure in a sex-specific manner in ApoE knockout mice.

Author

Fiamingo M, Toler S, Lee K, Oshiro W, Krantz T, Evansky P, Davies D, Gilmour MI, Farraj A, and Hazari MS

Abstract

Although it is well established that wildfire smoke exposure can increase cardiovascular morbidity and mortality, the combined effects of non-chemical stressors and wildfire smoke remains understudied. Housing is a non-chemical stressor that is a major determinant of cardiovascular health, however, disparities in neighborhood and social status have exacerbated the cardiovascular health gaps within the United States. Further, pre-existing cardiovascular morbidities, such as atherosclerosis, can worsen the response to wildfire smoke exposures. This represents a potentially hazardous interaction between inadequate housing and stress, cardiovascular morbidities, and worsened responses to wildfire smoke exposures. The purpose of this study was to examine the effects of enriched (EH) versus depleted (DH) housing on pulmonary and cardiovascular responses to a single flaming eucalyptus wildfire smoke (WS) exposure in male and female apolipoprotein E (ApoE) knockout mice, which develop an atherosclerosis-like phenotype. The results of this study show that cardiopulmonary responses to WS exposure occur in a sex-specific manner. EH blunts adverse WS-induced ventilatory responses, specifically an increase in tidal volume (TV), expiratory time (Te), and relaxation time (RT) after a WS exposure, but only in females. EH also blunted a WS-induced increase in isovolumic relaxation time (IVRT) and the myocardial performance index (MPI) 1-wk after exposures, also only in females. Our results suggest that housing alters the cardiovascular response to a single WS exposure, and that DH might cause increased susceptibility to environmental exposures that manifest in altered ventilation patterns and diastolic dysfunction in a sex-specific manner., Competing Interests: Additional Information The authors declare no competing financial interests.

Published
2024
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