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12. Supplementary Data from ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer

Author

Centenera, Margaret M., primary, Scott, Julia S., primary, Machiels, Jelle, primary, Nassar, Zeyad D., primary, Miller, Deanna C., primary, Zinonos, Irene, primary, Dehairs, Jonas, primary, Burvenich, Ingrid J.G., primary, Zadra, Giorgia, primary, Chetta, Paolo M., primary, Bango, Clyde, primary, Evergren, Emma, primary, Ryan, Natalie K., primary, Gillis, Joanna L., primary, Mah, Chui Yan, primary, Tieu, Terence, primary, Hanson, Adrienne R., primary, Carelli, Ryan, primary, Bloch, Katarzyna, primary, Panagopoulos, Vasilios, primary, Waelkens, Etienne, primary, Derua, Rita, primary, Williams, Elizabeth D., primary, Evdokiou, Andreas, primary, Cifuentes-Rius, Anna, primary, Voelcker, Nicolas H., primary, Mills, Ian G., primary, Tilley, Wayne D., primary, Scott, Andrew M., primary, Loda, Massimo, primary, Selth, Luke A., primary, Swinnen, Johannes V., primary, and Butler, Lisa M., primary

Published
2023
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13. Data from ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer

Author

Centenera, Margaret M., primary, Scott, Julia S., primary, Machiels, Jelle, primary, Nassar, Zeyad D., primary, Miller, Deanna C., primary, Zinonos, Irene, primary, Dehairs, Jonas, primary, Burvenich, Ingrid J.G., primary, Zadra, Giorgia, primary, Chetta, Paolo M., primary, Bango, Clyde, primary, Evergren, Emma, primary, Ryan, Natalie K., primary, Gillis, Joanna L., primary, Mah, Chui Yan, primary, Tieu, Terence, primary, Hanson, Adrienne R., primary, Carelli, Ryan, primary, Bloch, Katarzyna, primary, Panagopoulos, Vasilios, primary, Waelkens, Etienne, primary, Derua, Rita, primary, Williams, Elizabeth D., primary, Evdokiou, Andreas, primary, Cifuentes-Rius, Anna, primary, Voelcker, Nicolas H., primary, Mills, Ian G., primary, Tilley, Wayne D., primary, Scott, Andrew M., primary, Loda, Massimo, primary, Selth, Luke A., primary, Swinnen, Johannes V., primary, and Butler, Lisa M., primary

Published
2023
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15. Supplementary Table 1 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Author

Pishas, Kathleen I., primary, Neuhaus, Susan J., primary, Clayer, Mark T., primary, Schreiber, Andreas W., primary, Lawrence, David M., primary, Perugini, Michelle, primary, Whitfield, Robert J., primary, Farshid, Gelareh, primary, Manavis, Jim, primary, Chryssidis, Steve, primary, Mayo, Bronwen J., primary, Haycox, Rebecca C., primary, Ho, Kristen, primary, Brown, Michael P., primary, D'Andrea, Richard J., primary, Evdokiou, Andreas, primary, Thomas, David M., primary, Desai, Jayesh, primary, Callen, David F., primary, and Neilsen, Paul M., primary

Published
2023
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16. Data from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Author

Pishas, Kathleen I., primary, Neuhaus, Susan J., primary, Clayer, Mark T., primary, Schreiber, Andreas W., primary, Lawrence, David M., primary, Perugini, Michelle, primary, Whitfield, Robert J., primary, Farshid, Gelareh, primary, Manavis, Jim, primary, Chryssidis, Steve, primary, Mayo, Bronwen J., primary, Haycox, Rebecca C., primary, Ho, Kristen, primary, Brown, Michael P., primary, D'Andrea, Richard J., primary, Evdokiou, Andreas, primary, Thomas, David M., primary, Desai, Jayesh, primary, Callen, David F., primary, and Neilsen, Paul M., primary

Published
2023
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17. Supplementary Figure 5 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Author

Pishas, Kathleen I., primary, Neuhaus, Susan J., primary, Clayer, Mark T., primary, Schreiber, Andreas W., primary, Lawrence, David M., primary, Perugini, Michelle, primary, Whitfield, Robert J., primary, Farshid, Gelareh, primary, Manavis, Jim, primary, Chryssidis, Steve, primary, Mayo, Bronwen J., primary, Haycox, Rebecca C., primary, Ho, Kristen, primary, Brown, Michael P., primary, D'Andrea, Richard J., primary, Evdokiou, Andreas, primary, Thomas, David M., primary, Desai, Jayesh, primary, Callen, David F., primary, and Neilsen, Paul M., primary

Published
2023
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18. Data from Loss of Osteoclasts Contributes to Development of Osteosarcoma Pulmonary Metastases

Author

Endo-Munoz, Liliana, primary, Cumming, Andrew, primary, Rickwood, Danny, primary, Wilson, Danielle, primary, Cueva, Claudia, primary, Ng, Charlotte, primary, Strutton, Geoffrey, primary, Cassady, A. Ian, primary, Evdokiou, Andreas, primary, Sommerville, Scott, primary, Dickinson, Ian, primary, Guminski, Alexander, primary, and Saunders, Nicholas A., primary

Published
2023
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19. Supplementary Figure 3 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Author

Pishas, Kathleen I., primary, Neuhaus, Susan J., primary, Clayer, Mark T., primary, Schreiber, Andreas W., primary, Lawrence, David M., primary, Perugini, Michelle, primary, Whitfield, Robert J., primary, Farshid, Gelareh, primary, Manavis, Jim, primary, Chryssidis, Steve, primary, Mayo, Bronwen J., primary, Haycox, Rebecca C., primary, Ho, Kristen, primary, Brown, Michael P., primary, D'Andrea, Richard J., primary, Evdokiou, Andreas, primary, Thomas, David M., primary, Desai, Jayesh, primary, Callen, David F., primary, and Neilsen, Paul M., primary

Published
2023
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20. Supplementary Figure 6 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Author

Pishas, Kathleen I., primary, Neuhaus, Susan J., primary, Clayer, Mark T., primary, Schreiber, Andreas W., primary, Lawrence, David M., primary, Perugini, Michelle, primary, Whitfield, Robert J., primary, Farshid, Gelareh, primary, Manavis, Jim, primary, Chryssidis, Steve, primary, Mayo, Bronwen J., primary, Haycox, Rebecca C., primary, Ho, Kristen, primary, Brown, Michael P., primary, D'Andrea, Richard J., primary, Evdokiou, Andreas, primary, Thomas, David M., primary, Desai, Jayesh, primary, Callen, David F., primary, and Neilsen, Paul M., primary

Published
2023
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21. Supplementary Methods, Figure Legends 1-2 from Loss of Osteoclasts Contributes to Development of Osteosarcoma Pulmonary Metastases

Author

Endo-Munoz, Liliana, primary, Cumming, Andrew, primary, Rickwood, Danny, primary, Wilson, Danielle, primary, Cueva, Claudia, primary, Ng, Charlotte, primary, Strutton, Geoffrey, primary, Cassady, A. Ian, primary, Evdokiou, Andreas, primary, Sommerville, Scott, primary, Dickinson, Ian, primary, Guminski, Alexander, primary, and Saunders, Nicholas A., primary

Published
2023
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22. Supplementary Figure 2 from Loss of Osteoclasts Contributes to Development of Osteosarcoma Pulmonary Metastases

Author

Endo-Munoz, Liliana, primary, Cumming, Andrew, primary, Rickwood, Danny, primary, Wilson, Danielle, primary, Cueva, Claudia, primary, Ng, Charlotte, primary, Strutton, Geoffrey, primary, Cassady, A. Ian, primary, Evdokiou, Andreas, primary, Sommerville, Scott, primary, Dickinson, Ian, primary, Guminski, Alexander, primary, and Saunders, Nicholas A., primary

Published
2023
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23. Supplementary Figure 1 from Loss of Osteoclasts Contributes to Development of Osteosarcoma Pulmonary Metastases

Author

Endo-Munoz, Liliana, primary, Cumming, Andrew, primary, Rickwood, Danny, primary, Wilson, Danielle, primary, Cueva, Claudia, primary, Ng, Charlotte, primary, Strutton, Geoffrey, primary, Cassady, A. Ian, primary, Evdokiou, Andreas, primary, Sommerville, Scott, primary, Dickinson, Ian, primary, Guminski, Alexander, primary, and Saunders, Nicholas A., primary

Published
2023
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24. Supplementary Figure 1 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Author

Pishas, Kathleen I., primary, Neuhaus, Susan J., primary, Clayer, Mark T., primary, Schreiber, Andreas W., primary, Lawrence, David M., primary, Perugini, Michelle, primary, Whitfield, Robert J., primary, Farshid, Gelareh, primary, Manavis, Jim, primary, Chryssidis, Steve, primary, Mayo, Bronwen J., primary, Haycox, Rebecca C., primary, Ho, Kristen, primary, Brown, Michael P., primary, D'Andrea, Richard J., primary, Evdokiou, Andreas, primary, Thomas, David M., primary, Desai, Jayesh, primary, Callen, David F., primary, and Neilsen, Paul M., primary

Published
2023
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25. Supplementary Figure 2 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Author

Pishas, Kathleen I., primary, Neuhaus, Susan J., primary, Clayer, Mark T., primary, Schreiber, Andreas W., primary, Lawrence, David M., primary, Perugini, Michelle, primary, Whitfield, Robert J., primary, Farshid, Gelareh, primary, Manavis, Jim, primary, Chryssidis, Steve, primary, Mayo, Bronwen J., primary, Haycox, Rebecca C., primary, Ho, Kristen, primary, Brown, Michael P., primary, D'Andrea, Richard J., primary, Evdokiou, Andreas, primary, Thomas, David M., primary, Desai, Jayesh, primary, Callen, David F., primary, and Neilsen, Paul M., primary

Published
2023
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46. Additional file 2 of Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice

Author

Sun, Xuan, Bernhardt, Sarah M., Glynn, Danielle J., Hodson, Leigh J., Woolford, Lucy, Evdokiou, Andreas, Yan, Cong, Du, Hong, Robertson, Sarah A., and Ingman, Wendy V.

Abstract

Additional file 2: Supplementary Figure 2. Representative images for isotype controls for F4/80 (A), CCR7 (B), iNOS (C), and CD68 (D) immunohistochemistry in mouse mammary gland (A-C) and human non-neoplastic breast tissue (D).

Published
2021
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47. Additional file 1 of Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice

Author

Sun, Xuan, Bernhardt, Sarah M., Glynn, Danielle J., Hodson, Leigh J., Woolford, Lucy, Evdokiou, Andreas, Yan, Cong, Du, Hong, Robertson, Sarah A., and Ingman, Wendy V.

Abstract

Additional file 1: Supplementary Figure 1. Representative images for single-stained controls for immunofluorescence of F4/80 (A-C) and pSMAD2 (D-E), showing F4/80 (red channel; A, D), pSMAD2 (green channel; B, E), and merged images showing co-localisation and DAPI (blue channel) nuclear stain (C, F).

Published
2021
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48. Additional file 3 of Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice

Author

Sun, Xuan, Bernhardt, Sarah M., Glynn, Danielle J., Hodson, Leigh J., Woolford, Lucy, Evdokiou, Andreas, Yan, Cong, Du, Hong, Robertson, Sarah A., and Ingman, Wendy V.

Abstract

Additional file 3: Supplementary Figure 3. Detection of latent TGFB1 in human non-neoplastic breast tissue. Anti-latent TGFB was used to detect TGFB1 expression in non-neoplastic human breast tissue (n=19) (A and B), and negative control of secondary antibody only (C). The sections were also counterstained with DAPI (D, E and F). Latent TGFB1 and DAPI were visualised simultaneously under a confocal microscope (G: merged picture of A and D; H: merged picture of B and E; I: merged picture of C and F). Immunostainings of A, D and G represented breast tissue with low level expression of TGFB1, whereas immunostainings of B, E and H represented breast tissue with high level expression of TGFB1.The application of secondary antibodies only on human breast tissue (C, F, and I) was used as negative control.

Published
2021
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50. ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer

Author

Centenera, Margaret M., Scott, Julia S., Machiels, Jelle, Nassar, Zeyad D., Miller, Deanna C., Zinonos, Irene, Dehairs, Jonas, Burvenich, Ingrid J.G., Zadra, Giorgia, Chetta, Paolo M., Bango, Clyde, Evergren, Emma, Ryan, Natalie K., Gillis, Joanna L., Mah, Chui Yan, Tieu, Terence, Hanson, Adrienne R., Carelli, Ryan, Bloch, Katarzyna, Panagopoulos, Vasilios, Waelkens, Etienne, Derua, Rita, Williams, Elizabeth D., Evdokiou, Andreas, Cifuentes-Rius, Anna, Voelcker, Nicolas H., Mills, Ian G., Tilley, Wayne D., Scott, Andrew M., Loda, Massimo, Selth, Luke A., Swinnen, Johannes V., Butler, Lisa M., Centenera, Margaret M., Scott, Julia S., Machiels, Jelle, Nassar, Zeyad D., Miller, Deanna C., Zinonos, Irene, Dehairs, Jonas, Burvenich, Ingrid J.G., Zadra, Giorgia, Chetta, Paolo M., Bango, Clyde, Evergren, Emma, Ryan, Natalie K., Gillis, Joanna L., Mah, Chui Yan, Tieu, Terence, Hanson, Adrienne R., Carelli, Ryan, Bloch, Katarzyna, Panagopoulos, Vasilios, Waelkens, Etienne, Derua, Rita, Williams, Elizabeth D., Evdokiou, Andreas, Cifuentes-Rius, Anna, Voelcker, Nicolas H., Mills, Ian G., Tilley, Wayne D., Scott, Andrew M., Loda, Massimo, Selth, Luke A., Swinnen, Johannes V., and Butler, Lisa M.

Abstract

The androgen receptor (AR) is the key oncogenic driver of prostate cancer, and despite implementation of novel AR targeting therapies, outcomes for metastatic disease remain dismal. There is an urgent need to better understand androgen-regulated cellular processes to more effectively target the AR dependence of prostate cancer cells through new therapeutic vulnerabilities. Transcriptomic studies have consistently identified lipid metabolism as a hallmark of enhanced AR signaling in prostate cancer, yet the relationship between AR and the lipidome remains undefined. Using mass spectrometry-based lipidomics, this study reveals increased fatty acyl chain length in phospholipids from prostate cancer cells and patient-derived explants as one of the most striking androgen-regulated changes to lipid metabolism. Potent and direct AR-mediated induction of ELOVL fatty acid elongase 5 (ELOVL5), an enzyme that catalyzes fatty acid elongation, was demonstrated in prostate cancer cells, xenografts, and clinical tumors. Assessment of mRNA and protein in large-scale data sets revealed ELOVL5 as the predominant ELOVL expressed and upregulated in prostate cancer compared with nonmalignant prostate. ELOVL5 depletion markedly altered mitochondrial morphology and function, leading to excess generation of reactive oxygen species and resulting in suppression of prostate cancer cell proliferation, 3D growth, and in vivo tumor growth and metastasis. Supplementation with the monounsaturated fatty acid cis-vaccenic acid, a direct product of ELOVL5 elongation, reversed the oxidative stress and associated cell proliferation and migration effects of ELOVL5 knockdown. Collectively, these results identify lipid elongation as a protumorigenic metabolic pathway in prostate cancer that is androgen-regulated, critical for metastasis, and targetable via ELOVL5.

Published
2021

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