Search

Your search keyword '"Evers, Lisa"' showing total 150 results
Start Over Author "Evers, Lisa"
150 results on '"Evers, Lisa"'

1. Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Author

Allison, Sarah, Bailey, Peter J., Bailey, Ulla-Maja, Biankin, Andrew V., Beraldi, Dario, Brunton, Holly, Caligiuri, Giuseppina, Cameron, Euan, Chang, David K., Cooke, Susanna L., Cunningham, Richard, Dreyer, Stephan, Grimwood, Paul, Kelly, Shane, Lampraki, Eirini-Maria, Marshall, John, Martin, Sancha, McDade, Brian, McElroy, Daniel, Musgrove, Elizabeth A., Nourse, Craig, Paulus-Hock, Viola, Ramsay, Donna, Upstill-Goddard, Rosie, Wright, Derek, Jones, Marc D., Evers, Lisa, Rebus, Selma, Rahib, Lola, Serrels, Bryan, Hair, Jane, Jamieson, Nigel B., McKay, Colin J., Westwood, Paul, Williams, Nicola, Duthie, Fraser, Johns, Amber L., Mawson, Amanda, Scarlett, Christopher J., Brancato, Mary-Anne L., Rowe, Sarah J., Simpson, Skye H., Martyn-Smith, Mona, Thomas, Michelle T., Chantrill, Lorraine A., Chin, Venessa T., Chou, Angela, Cowley, Mark J., Humphris, Jeremy L., Mead, R. Scott, Nagrial, Adnan M., Pajic, Marina, Pettit, Jessica, Pinese, Mark, Rooman, Ilse, Wu, Jianmin, Tao, Jiang, DiPietro, Renee, Watson, Clare, Steinmann, Angela, Lee, Hong Ching, Wong, Rachel, Pinho, Andreia V., Giry-Laterriere, Marc, Daly, Roger J., Sutherland, Robert L., Grimmond, Sean M., Waddell, Nicola, Kassahn, Karin S., Miller, David K., Wilson, Peter J., Patch, Ann-Marie, Song, Sarah, Harliwong, Ivon, Idrisoglu, Senel, Nourbakhsh, Ehsan, Manning, Suzanne, Wani, Shivangi, Gongora, Milena, Anderson, Matthew, Holmes, Oliver, Leonard, Conrad, Taylor, Darrin, Wood, Scott, Xu, Christina, Nones, Katia, Fink, J. Lynn, Christ, Angelika, Bruxner, Tim, Cloonan, Nicole, Newell, Felicity, Pearson, John V., Bailey, Peter, Quinn, Michael, Nagaraj, Shivashankar, Kazakoff, Stephen, Waddell, Nick, Krisnan, Keerthana, Quek, Kelly, Wood, David, Samra, Jaswinder S., Gill, Anthony J., Pavlakis, Nick, Guminski, Alex, Toon, Christopher, Asghari, Ray, Merrett, Neil D., Pavey, Darren, Das, Amitabha, Cosman, Peter H., Ismail, Kasim, O’Connnor, Chelsie, Lam, Vincent W., McLeod, Duncan, Pleass, Henry C., Richardson, Arthur, James, Virginia, Kench, James G., Cooper, Caroline L., Joseph, David, Sandroussi, Charbel, Crawford, Michael, Gallagher, James, Texler, Michael, Forest, Cindy, Laycock, Andrew, Epari, Krishna P., Ballal, Mo, Fletcher, David R., Mukhedkar, Sanjay, Spry, Nigel A., DeBoer, Bastiaan, Chai, Ming, Zeps, Nikolajs, Beilin, Maria, Feeney, Kynan, Nguyen, Nan Q., Ruszkiewicz, Andrew R., Worthley, Chris, Tan, Chuan P., Debrencini, Tamara, Chen, John, Brooke-Smith, Mark E., Papangelis, Virginia, Tang, Henry, Barbour, Andrew P., Clouston, Andrew D., Martin, Patrick, O’Rourke, Thomas J., Chiang, Amy, Fawcett, Jonathan W., Slater, Kellee, Yeung, Shinn, Hatzifotis, Michael, Hodgkinson, Peter, Christophi, Christopher, Nikfarjam, Mehrdad, Mountain, Angela, Biobank, Victorian Cancer, Eshleman, James R., Hruban, Ralph H., Maitra, Anirban, Iacobuzio-Donahue, Christine A., Schulick, Richard D., Wolfgang, Christopher L., Morgan, Richard A., Hodgin, Mary, Scarpa, Aldo, Lawlor, Rita T., Beghelli, Stefania, Corbo, Vincenzo, Scardoni, Maria, Bassi, Claudio, Tempero, Margaret A., Graham, Janet S., Dreyer, Stephan B., Paris, Clara, Dray, Eloise, Plenker, Dennis, Galluzzo, Zachary, Tesson, Mathias, Jones, Marc, Moran-Jones, Kim, Wright, Derek W., Oien, Karin, McGregor, Grant A., Gulati, Aditi, Brough, Rachel, Bajrami, Ilirjana, Pettitt, Stephan, Dziubinski, Michele L., Candido, Juliana, Balkwill, Frances, Barry, Simon T., Grützmann, Robert, Johns, Amber, Froeling, Fieke E.M., Beer, Phillip, Petersen, Gloria M., Ashworth, Alan, Frame, Margaret C., Crawford, Howard C., Simeone, Diane M., Lord, Chris, Mukhopadhyay, Debabrata, Pilarsky, Christian, Tuveson, David A., Morton, Jennifer P., and Sansom, Owen J.

Published
2021
Full Text
View/download PDF

5. Table S2 from Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma

Author

Vaubel, Rachael A., primary, Tian, Shulan, primary, Remonde, Dioval, primary, Schroeder, Mark A., primary, Mladek, Ann C., primary, Kitange, Gaspar J., primary, Caron, Alissa, primary, Kollmeyer, Thomas M., primary, Grove, Rebecca, primary, Peng, Sen, primary, Carlson, Brett L., primary, Ma, Daniel J., primary, Sarkar, Gobinda, primary, Evers, Lisa, primary, Decker, Paul A., primary, Yan, Huihuang, primary, Dhruv, Harshil D., primary, Berens, Michael E., primary, Wang, Qianghu, primary, Marin, Bianca M., primary, Klee, Eric W., primary, Califano, Andrea, primary, LaChance, Daniel H., primary, Eckel-Passow, Jeanette E., primary, Verhaak, Roel G., primary, Sulman, Erik P., primary, Burns, Terry C., primary, Meyer, Fredrick B., primary, O'Neill, Brian P., primary, Tran, Nhan L., primary, Giannini, Caterina, primary, Jenkins, Robert B., primary, Parney, Ian F., primary, and Sarkaria, Jann N., primary

Published
2023
Full Text
View/download PDF

6. Table S7 from The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma

Author

Cooke, Susanna L., primary, Ennis, Darren, primary, Evers, Lisa, primary, Dowson, Suzanne, primary, Chan, Mei Yen, primary, Paul, James, primary, Hirschowitz, Lynn, primary, Glasspool, Rosalind M., primary, Singh, Naveena, primary, Bell, Sarah, primary, Day, Elizabeth, primary, Kochman, Agata, primary, Wilkinson, Nafisa, primary, Beer, Philip, primary, Martin, Sancha, primary, Millan, David, primary, Biankin, Andrew V., primary, and McNeish, Iain A., primary

Published
2023
Full Text
View/download PDF

7. Figure S3 from The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma

Author

Cooke, Susanna L., primary, Ennis, Darren, primary, Evers, Lisa, primary, Dowson, Suzanne, primary, Chan, Mei Yen, primary, Paul, James, primary, Hirschowitz, Lynn, primary, Glasspool, Rosalind M., primary, Singh, Naveena, primary, Bell, Sarah, primary, Day, Elizabeth, primary, Kochman, Agata, primary, Wilkinson, Nafisa, primary, Beer, Philip, primary, Martin, Sancha, primary, Millan, David, primary, Biankin, Andrew V., primary, and McNeish, Iain A., primary

Published
2023
Full Text
View/download PDF

8. Supplementary methods and legends from The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma

Author

Cooke, Susanna L., primary, Ennis, Darren, primary, Evers, Lisa, primary, Dowson, Suzanne, primary, Chan, Mei Yen, primary, Paul, James, primary, Hirschowitz, Lynn, primary, Glasspool, Rosalind M., primary, Singh, Naveena, primary, Bell, Sarah, primary, Day, Elizabeth, primary, Kochman, Agata, primary, Wilkinson, Nafisa, primary, Beer, Philip, primary, Martin, Sancha, primary, Millan, David, primary, Biankin, Andrew V., primary, and McNeish, Iain A., primary

Published
2023
Full Text
View/download PDF

9. Supplementary Materials from Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma

Author

Vaubel, Rachael A., primary, Tian, Shulan, primary, Remonde, Dioval, primary, Schroeder, Mark A., primary, Mladek, Ann C., primary, Kitange, Gaspar J., primary, Caron, Alissa, primary, Kollmeyer, Thomas M., primary, Grove, Rebecca, primary, Peng, Sen, primary, Carlson, Brett L., primary, Ma, Daniel J., primary, Sarkar, Gobinda, primary, Evers, Lisa, primary, Decker, Paul A., primary, Yan, Huihuang, primary, Dhruv, Harshil D., primary, Berens, Michael E., primary, Wang, Qianghu, primary, Marin, Bianca M., primary, Klee, Eric W., primary, Califano, Andrea, primary, LaChance, Daniel H., primary, Eckel-Passow, Jeanette E., primary, Verhaak, Roel G., primary, Sulman, Erik P., primary, Burns, Terry C., primary, Meyer, Fredrick B., primary, O'Neill, Brian P., primary, Tran, Nhan L., primary, Giannini, Caterina, primary, Jenkins, Robert B., primary, Parney, Ian F., primary, and Sarkaria, Jann N., primary

Published
2023
Full Text
View/download PDF

10. Data from Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma

Author

Vaubel, Rachael A., primary, Tian, Shulan, primary, Remonde, Dioval, primary, Schroeder, Mark A., primary, Mladek, Ann C., primary, Kitange, Gaspar J., primary, Caron, Alissa, primary, Kollmeyer, Thomas M., primary, Grove, Rebecca, primary, Peng, Sen, primary, Carlson, Brett L., primary, Ma, Daniel J., primary, Sarkar, Gobinda, primary, Evers, Lisa, primary, Decker, Paul A., primary, Yan, Huihuang, primary, Dhruv, Harshil D., primary, Berens, Michael E., primary, Wang, Qianghu, primary, Marin, Bianca M., primary, Klee, Eric W., primary, Califano, Andrea, primary, LaChance, Daniel H., primary, Eckel-Passow, Jeanette E., primary, Verhaak, Roel G., primary, Sulman, Erik P., primary, Burns, Terry C., primary, Meyer, Fredrick B., primary, O'Neill, Brian P., primary, Tran, Nhan L., primary, Giannini, Caterina, primary, Jenkins, Robert B., primary, Parney, Ian F., primary, and Sarkaria, Jann N., primary

Published
2023
Full Text
View/download PDF

14. Genomic analyses identify molecular subtypes of pancreatic cancer

Author

Bailey, Peter, Chang, David K., Nones, Katia, Johns, Amber L., Patch, Ann-Marie, Gingras, Marie-Claude, Miller, David K., Christ, Angelika N., Bruxner, Tim J. C., Quinn, Michael C., Nourse, Craig, Murtaugh, L. Charles, Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourbakhsh, Ehsan, Wani, Shivangi, Fink, Lynn, Holmes, Oliver, Chin, Venessa, Anderson, Matthew J., Kazakoff, Stephen, Leonard, Conrad, Newell, Felicity, Waddell, Nick, Wood, Scott, Xu, Qinying, Wilson, Peter J., Cloonan, Nicole, Kassahn, Karin S., Taylor, Darrin, Quek, Kelly, Robertson, Alan, Pantano, Lorena, Mincarelli, Laura, Sanchez, Luis N., Evers, Lisa, Wu, Jianmin, Pinese, Mark, Cowley, Mark J., Jones, Marc D., Colvin, Emily K., Nagrial, Adnan M., Humphrey, Emily S., Chantrill, Lorraine A., Mawson, Amanda, Humphris, Jeremy, Chou, Angela, Pajic, Marina, Scarlett, Christopher J., Pinho, Andreia V., Giry-Laterriere, Marc, Rooman, Ilse, Samra, Jaswinder S., Kench, James G., Lovell, Jessica A., Merrett, Neil D., Toon, Christopher W., Epari, Krishna, Nguyen, Nam Q., Barbour, Andrew, Zeps, Nikolajs, Moran-Jones, Kim, Jamieson, Nigel B., Graham, Janet S., Duthie, Fraser, Oien, Karin, Hair, Jane, Grützmann, Robert, Maitra, Anirban, Iacobuzio-Donahue, Christine A., Wolfgang, Christopher L., Morgan, Richard A., Lawlor, Rita T., Corbo, Vincenzo, Bassi, Claudio, Rusev, Borislav, Capelli, Paola, Salvia, Roberto, Tortora, Giampaolo, Mukhopadhyay, Debabrata, Petersen, Gloria M., Munzy, Donna M., Fisher, William E., Karim, Saadia A., Eshleman, James R., Hruban, Ralph H., Pilarsky, Christian, Morton, Jennifer P., Sansom, Owen J., Scarpa, Aldo, Musgrove, Elizabeth A., Bailey, Ulla-Maja Hagbo, Hofmann, Oliver, Sutherland, Robert L., Wheeler, David A., Gill, Anthony J., Gibbs, Richard A., Pearson, John V., Waddell, Nicola, Biankin, Andrew V., and Grimmond, Sean M.

Published
2016
Full Text
View/download PDF

16. Advancing a clinically relevant perspective of the clonal nature of cancer

Author

Ruiz, Christian, Lenkiewicz, Elizabeth, Evers, Lisa, Holley, Tara, Robeson, Alex, Kiefer, Jeffrey, Demeure, Michael J., Hollingsworth, Michael A., Shen, Michael, Prunkard, Donna, Rabinovitch, Peter S., Zellweger, Tobias, Mousses, Spyro, Trent, Jeffrey M., Carpten, John D., Bubendorf, Lukas, Von Hoff, Daniel, and Barrett, Michael T.

Published
2011

17. Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence

Author

Dreyer, Stephan B., primary, Upstill-Goddard, Rosie, additional, Legrini, Assya, additional, Biankin, Andrew V., additional, Jamieson, Nigel B., additional, Chang, David K., additional, Allison, Sarah, additional, Beraldi, Dario, additional, Cameron, Euan, additional, Cooke, Susanna L., additional, Cunningham, Richard, additional, Dreyer, Stephan, additional, Grimwood, Paul, additional, Kelly, Shane, additional, Marshall, John, additional, McDade, Brian, additional, Musgrove, Elizabeth A., additional, Ramsay, Donna, additional, Evers, Lisa, additional, Rebus, Selma, additional, Rahib, Lola, additional, Serrels, Bryan, additional, McKay, Colin J., additional, Westwood, Paul, additional, Williams, Nicola, additional, Duthie, Fraser, additional, Shen, William, additional, Pea, Antonio, additional, Johns, Amber L., additional, Gill, Anthony J., additional, Chantrill, Lorraine A., additional, Timpson, Paul, additional, Chou, Angela, additional, Pajic, Marina, additional, Dwarte, Tanya, additional, Herrmann, David, additional, Vennin, Claire, additional, Cox, Thomas R., additional, Pereira, Brooke, additional, Ritchiee, Shona, additional, Reed, Daniel A., additional, Chambers, Cecilia R., additional, Metcalf, Xanthe, additional, Nobis, Max, additional, Jeong, Gloria, additional, Kenyon, Lara, additional, Lyons, Ruth J., additional, Waddell, Nicola, additional, Pearson, John V., additional, Patch, Ann-Marie, additional, Nones, Katia, additional, Newell, Felicity, additional, Mukhopadhyay, Pamela, additional, Addala, Venkateswar, additional, Kazakoff, Stephen, additional, Holmes, Oliver, additional, Leonard, Conrad, additional, Wood, Scott, additional, Grimmond, Sean M., additional, Hofmann, Oliver, additional, Samra, Jaswinder S., additional, Pavlakis, Nick, additional, Arena, Jennifer, additional, High, Hilda A., additional, Asghari, Ray, additional, Merrett, Neil D., additional, Das, Amitabha, additional, Cosman, Peter H., additional, Ismail, Kasim, additional, Stoita, Alina, additional, Williams, David, additional, Spigellman, Allan, additional, McLeod, Duncan, additional, Kirk, Judy, additional, Kench, James G., additional, Grimison, Peter, additional, Sandroussi, Charbel, additional, Goodwin, Annabel, additional, Mead, R. Scott, additional, Tucker, Katherine, additional, Andrews, Lesley, additional, Texler, Michael, additional, Forrest, Cindy, additional, Ballal, Mo, additional, Fletcher, David, additional, Beilin, Maria, additional, Feeney, Kynan, additional, Epari, Krishna, additional, Mukhedkar, Sanjay, additional, Zeps, Nikolajs, additional, Nguyen, Nan Q., additional, Ruszkiewicz, Andrew R., additional, Worthley, Chris, additional, Chen, John, additional, Brooke-Smith, Mark E., additional, Papangelis, Virginia, additional, Clouston, Andrew D., additional, Barbour, Andrew P., additional, O’Rourke, Thomas J., additional, Fawcett, Jonathan W., additional, Slater, Kellee, additional, Hatzifotis, Michael, additional, Hodgkinson, Peter, additional, Nikfarjam, Mehrdad, additional, Eshleman, James R., additional, Hruban, Ralph H., additional, Wolfgang, Christopher L., additional, Scarpa, Aldo, additional, Lawlor, Rita T., additional, Corbo, Vincenzo, additional, Bassi, Claudio, additional, and Dreyer, Stephan B., additional

Published
2022
Full Text
View/download PDF

19. Targeting DNA damage response and replication stress in pancreatic cancer

Author

Dreyer, Stephan B., Upstill-Goddard, Rosie, Paulus-Hock, Viola, Paris, Clara, Lampraki, Eirini-Maria, Dray, Eloise, Serrels, Bryan, Caligiuri, Giuseppina, Rebus, Selma, Plenker, Dennis, Galluzzo, Zachary, Brunton, Holly, Cunningham, Richard, Tesson, Mathias, Nourse, Craig, Bailey, Ulla-Maja, Jones, Marc, Moran-Jones, Kim, Wright, Derek W., Duthie, Fraser, Oien, Karin, Evers, Lisa, McKay, Colin J., McGregor, Grant A., Gulati, Aditi, Brough, Rachel, Bajrami, Ilirjana, Pettitt, Stephan, Dziubinski, Michele L., Candido, Juliana, Balkwill, Frances, Barry, Simon T., Grützmann, Robert, Rahib, Lola, Glasgow Precision Oncology Laboratory, Australian Pancreatic Cancer Genome Initiative, Johns, Amber, Pajic, Mariana, Froeling, Fieke E.M., Beer, Phillip, Musgrove, Eilzabeth A., Petersen, Gloria M., Ashworth, Alan, Frame, Margaret C., Crawford, Howard C., Simeone, Diane M., Lord, Chris, Mukhopadhyay, Debabrata, Pilarsky, Christian, Tuveson, David A., Cooke, Susanna L., Jamieson, Nigel B., Morton, Jennifer P., Sansom, Owen J., Bailey, Peter J., Biankin, Andrew V., and Chang, David K.

Subjects
body regions
Abstract

Background and aims:\ud Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress and novel therapeutic response in PC to develop a biomarker driven therapeutic strategy targeting DDR and replication stress in PC.\ud \ud Methods:\ud We interrogated the transcriptome, genome, proteome and functional characteristics of 61 novel PC patient-derived cell lines to define novel therapeutic strategies targeting DDR and replication stress. Validation was done in patient derived xenografts and human PC organoids.\ud \ud Results:\ud Patient-derived cell lines faithfully recapitulate the epithelial component of pancreatic tumors including previously described molecular subtypes. Biomarkers of DDR deficiency, including a novel signature of homologous recombination deficiency, co-segregates with response to platinum (P < 0.001) and PARP inhibitor therapy (P < 0.001) in vitro and in vivo. We generated a novel signature of replication stress with which predicts response to ATR (P < 0.018) and WEE1 inhibitor (P < 0.029) treatment in both cell lines and human PC organoids. Replication stress was enriched in the squamous subtype of PC (P < 0.001) but not associated with DDR deficiency.\ud \ud Conclusions:\ud Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR proficient PC, and post-platinum therapy.

Published
2021

22. HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Author

Brunton, Holly, primary, Caligiuri, Giuseppina, additional, Cunningham, Richard, additional, Upstill-Goddard, Rosie, additional, Bailey, Ulla-Maja, additional, Garner, Ian M., additional, Nourse, Craig, additional, Dreyer, Stephan, additional, Jones, Marc, additional, Moran-Jones, Kim, additional, Wright, Derek W., additional, Paulus-Hock, Viola, additional, Nixon, Colin, additional, Thomson, Gemma, additional, Jamieson, Nigel B., additional, McGregor, Grant A., additional, Evers, Lisa, additional, McKay, Colin J., additional, Gulati, Aditi, additional, Brough, Rachel, additional, Bajrami, Ilirjana, additional, Pettitt, Stephen J., additional, Dziubinski, Michele L., additional, Barry, Simon T., additional, Grützmann, Robert, additional, Brown, Robert, additional, Curry, Edward, additional, Pajic, Marina, additional, Musgrove, Elizabeth A., additional, Petersen, Gloria M., additional, Shanks, Emma, additional, Ashworth, Alan, additional, Crawford, Howard C., additional, Simeone, Diane M., additional, Froeling, Fieke E.M., additional, Lord, Christopher J., additional, Mukhopadhyay, Debabrata, additional, Pilarsky, Christian, additional, Grimmond, Sean E., additional, Morton, Jennifer P., additional, Sansom, Owen J., additional, Chang, David K., additional, Bailey, Peter J., additional, Biankin, Andrew V., additional, Allison, Sarah, additional, Cooke, Susanna L., additional, Grimwood, Paul, additional, Kelly, Shane, additional, Marshall, John, additional, McDade, Brian, additional, McElroy, Daniel, additional, Ramsay, Donna, additional, Rebus, Selma, additional, Hair, Jane, additional, Westwood, Paul, additional, Williams, Nicola, additional, Duthie, Fraser, additional, Johns, Amber L., additional, Mawson, Amanda, additional, Scarlett, Christopher J., additional, Brancato, Mary-Anne L., additional, Rowe, Sarah J., additional, Simpson, Skye H., additional, Martyn-Smith, Mona, additional, Thomas, Michelle T., additional, Chantrill, Lorraine A., additional, Chin, Venessa T., additional, Chou, Angela, additional, Cowley, Mark J., additional, Humphris, Jeremy L., additional, Mead, R. Scott, additional, Nagrial, Adnan M., additional, Pettit, Jessica, additional, Pinese, Mark, additional, Rooman, Ilse, additional, Wu, Jianmin, additional, Tao, Jiang, additional, DiPietro, Renee, additional, Watson, Clare, additional, Steinmann, Angela, additional, Lee, Hong Ching, additional, Wong, Rachel, additional, Pinho, Andreia V., additional, Giry-Laterriere, Marc, additional, Daly, Roger J., additional, Sutherland, Robert L., additional, Grimmond, Sean M., additional, Waddell, Nicola, additional, Kassahn, Karin S., additional, Miller, David K., additional, Wilson, Peter J., additional, Patch, Ann-Marie, additional, Song, Sarah, additional, Harliwong, Ivon, additional, Idrisoglu, Senel, additional, Nourbakhsh, Ehsan, additional, Manning, Suzanne, additional, Wani, Shivangi, additional, Gongora, Milena, additional, Anderson, Matthew, additional, Holmes, Oliver, additional, Leonard, Conrad, additional, Taylor, Darrin, additional, Wood, Scott, additional, Xu, Christina, additional, Nones, Katia, additional, Fink, J. Lynn, additional, Christ, Angelika, additional, Bruxner, Tim, additional, Cloonan, Nicole, additional, Newell, Felicity, additional, Pearson, John V., additional, Quinn, Michael, additional, Nagaraj, Shivashankar, additional, Kazakoff, Stephen, additional, Waddell, Nick, additional, Krisnan, Keerthana, additional, Quek, Kelly, additional, Wood, David, additional, Samra, Jaswinder S., additional, Gill, Anthony J., additional, Pavlakis, Nick, additional, Guminski, Alex, additional, Toon, Christopher, additional, Asghari, Ray, additional, Merrett, Neil D., additional, Pavey, Darren, additional, Das, Amitabha, additional, Cosman, Peter H., additional, Ismail, Kasim, additional, O’Connnor, Chelsie, additional, Lam, Vincent W., additional, McLeod, Duncan, additional, Pleass, Henry C., additional, Richardson, Arthur, additional, James, Virginia, additional, Kench, James G., additional, Cooper, Caroline L., additional, Joseph, David, additional, Sandroussi, Charbel, additional, Crawford, Michael, additional, Gallagher, James, additional, Texler, Michael, additional, Forest, Cindy, additional, Laycock, Andrew, additional, Epari, Krishna P., additional, Ballal, Mo, additional, Fletcher, David R., additional, Mukhedkar, Sanjay, additional, Spry, Nigel A., additional, DeBoer, Bastiaan, additional, Chai, Ming, additional, Zeps, Nikolajs, additional, Beilin, Maria, additional, Feeney, Kynan, additional, Nguyen, Nan Q., additional, Ruszkiewicz, Andrew R., additional, Worthley, Chris, additional, Tan, Chuan P., additional, Debrencini, Tamara, additional, Chen, John, additional, Brooke-Smith, Mark E., additional, Papangelis, Virginia, additional, Tang, Henry, additional, Barbour, Andrew P., additional, Clouston, Andrew D., additional, Martin, Patrick, additional, O’Rourke, Thomas J., additional, Chiang, Amy, additional, Fawcett, Jonathan W., additional, Slater, Kellee, additional, Yeung, Shinn, additional, Hatzifotis, Michael, additional, Hodgkinson, Peter, additional, Christophi, Christopher, additional, Nikfarjam, Mehrdad, additional, Mountain, Angela, additional, Eshleman, James R., additional, Hruban, Ralph H., additional, Maitra, Anirban, additional, Iacobuzio-Donahue, Christine A., additional, Schulick, Richard D., additional, Wolfgang, Christopher L., additional, Morgan, Richard A., additional, Hodgin, Mary, additional, Scarpa, Aldo, additional, Lawlor, Rita T., additional, Beghelli, Stefania, additional, Corbo, Vincenzo, additional, Scardoni, Maria, additional, Bassi, Claudio, additional, Tempero, Margaret A., additional, and Graham, Janet S., additional

Published
2020
Full Text
View/download PDF

23. Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma

Author

Vaubel, Rachael A., primary, Tian, Shulan, additional, Remonde, Dioval, additional, Schroeder, Mark A., additional, Mladek, Ann C., additional, Kitange, Gaspar J., additional, Caron, Alissa, additional, Kollmeyer, Thomas M., additional, Grove, Rebecca, additional, Peng, Sen, additional, Carlson, Brett L., additional, Ma, Daniel J., additional, Sarkar, Gobinda, additional, Evers, Lisa, additional, Decker, Paul A., additional, Yan, Huihuang, additional, Dhruv, Harshil D., additional, Berens, Michael E., additional, Wang, Qianghu, additional, Marin, Bianca M., additional, Klee, Eric W., additional, Califano, Andrea, additional, LaChance, Daniel H., additional, Eckel-Passow, Jeanette E., additional, Verhaak, Roel G., additional, Sulman, Erik P., additional, Burns, Terry C., additional, Meyer, Fredrick B., additional, O'Neill, Brian P., additional, Tran, Nhan L., additional, Giannini, Caterina, additional, Jenkins, Robert B., additional, Parney, Ian F., additional, and Sarkaria, Jann N., additional

Published
2020
Full Text
View/download PDF

24. Feasibility and clinical utility of endoscopic ultrasound guided biopsy of pancreatic cancer for next-generation molecular profiling

Author

Dreyer, Stephan B., primary, Jamieson, Nigel B., additional, Evers, Lisa, additional, Duthie, Fraser, additional, Cooke, Susie, additional, Marshall, John, additional, Beraldi, Dario, additional, Knight, Stephen, additional, Upstill-Goddard, Rosanna, additional, Dickson, Euan J., additional, Carter, C. Ross, additional, McKay, Colin J., additional, Biankin, Andrew V., additional, and Chang, David K., additional

Published
2019
Full Text
View/download PDF

25. HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Author

Brunton, Holly, primary, Caligiuri, Giuseppina, additional, Cunningham, Richard, additional, Upstill-Goddard, Rosie, additional, Bailey, Ulla-Maja, additional, Garner, Ian M., additional, Nourse, Craig, additional, Dreyer, Stephan, additional, Jones, Marc, additional, Moran-Jones, Kim, additional, Wright, Derek W., additional, Paulus-Hock, Viola, additional, Nixon, Colin, additional, Thomson, Gemma, additional, Jamieson, Nigel, additional, McGregor, Grant A., additional, Evers, Lisa, additional, McKay, Colin J., additional, Gulati, Aditi, additional, Brough, Rachel, additional, Bajrami, Ilirjana, additional, Pettit, Stephen, additional, Dziubinski, Michele L., additional, Barry, Simon T., additional, Grützmann, Robert, additional, Brown, Robert, additional, Curry, Edward, additional, Laboratory, Glasgow Precision Oncology, additional, Initiative, Australian Pancreatic Cancer Genome, additional, Pajic, Marina, additional, Musgrove, Elizabeth A., additional, Petersen, Gloria, additional, Shanks, Emma, additional, Ashworth, Alan, additional, Crawford, Howard C., additional, Simeone, Diane M., additional, Froeling, Fieke E.M., additional, Lord, Christopher J., additional, Mukhopadhyay, Debabrata, additional, Pilarsky, Christian, additional, Grimmond, Sean E., additional, Morton, Jennifer P., additional, Sansom, Owen J., additional, Chang, David K., additional, Bailey, Peter, additional, and Biankin, Andrew V., additional

Published
2019
Full Text
View/download PDF

26. TMOD-18. THE PATIENT DERIVED XENOGRAFT NATIONAL RESOURCE: A COMPREHENSIVE COLLECTION OF HIGH-GRADE GLIOMA MODELS FOR PRE-CLINICAL AND TRANSLATIONAL STUDIES

Author

Vaubel, Rachael, primary, Tian, Shulan, additional, Remonde, Dioval, additional, Schroeder, Mark, additional, Kollmeyer, Thomas, additional, Peng, Sen, additional, Mladek, Ann, additional, Carlson, Brett, additional, Ma, Daniel, additional, Kitange, Gaspar, additional, Evers, Lisa, additional, Decker, Paul, additional, Kosel, Matthew, additional, Berens, Michael, additional, Klee, Eric, additional, Califano, Andrea, additional, James, C David, additional, Lachance, Daniel, additional, Eckel-Passow, Jeanette, additional, Verhaak, Roel, additional, Sulman, Erik, additional, Tran, Nhan, additional, Giannini, Caterina, additional, Jenkins, Robert, additional, Parney, Ian, additional, and Sarkaria, Jann, additional

Published
2018
Full Text
View/download PDF

27. Feasibility and clinical utility of EUS guided biopsy of pancreatic cancer for next-generation genomic sequencing.

Author

Dreyer, Stephan, primary, Jamieson, Nigel, additional, Evers, Lisa, additional, Jones, Marc, additional, Martin, Sancha, additional, Duthie, Fraser, additional, Musgrove, Liz, additional, Cooke, Susie, additional, Bailey, Peter, additional, McKay, Colin, additional, Chang, David Kuang-Fu, additional, and Biankin, Andrew, additional

Published
2018
Full Text
View/download PDF

29. The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma

Author

Cooke, Susanna L., primary, Ennis, Darren, additional, Evers, Lisa, additional, Dowson, Suzanne, additional, Chan, Mei Yen, additional, Paul, James, additional, Hirschowitz, Lynn, additional, Glasspool, Rosalind M., additional, Singh, Naveena, additional, Bell, Sarah, additional, Day, Elizabeth, additional, Kochman, Agata, additional, Wilkinson, Nafisa, additional, Beer, Philip, additional, Martin, Sancha, additional, Millan, David, additional, Biankin, Andrew V., additional, and McNeish, Iain A., additional

Published
2017
Full Text
View/download PDF

30. Clinical study of genomic drivers in pancreatic ductal adenocarcinoma

Author

Barrett, Michael T, primary, Deiotte, Ray, additional, Lenkiewicz, Elizabeth, additional, Malasi, Smriti, additional, Holley, Tara, additional, Evers, Lisa, additional, Posner, Richard G, additional, Jones, Timothy, additional, Han, Haiyong, additional, Sausen, Mark, additional, Velculescu, Victor E, additional, Drebin, Jeffrey, additional, O'Dwyer, Peter, additional, Jameson, Gayle, additional, Ramanathan, Ramesh K, additional, and Von Hoff, Daniel D, additional

Published
2017
Full Text
View/download PDF

31. Feasibility and clinical utility of EUS guided biopsy of pancreatic cancer for next-generation genomic sequencing.

Author

Dreyer, Stephan, primary, Jamieson, Nigel, additional, Evers, Lisa, additional, Jones, Marc, additional, Martin, Sancha, additional, Duthie, Fraser, additional, Musgrove, Liz, additional, Cooke, Susie, additional, Bailey, Peter, additional, McKay, Colin J, additional, Chang, David Kuang-Fu, additional, and Biankin, Andrew, additional

Published
2017
Full Text
View/download PDF

32. Fiscal Investment Climate and the Cost of Capital in Germany

Author

Evers, Lisa, Spengel, Christoph, and Braun, Julia

Subjects
330 Wirtschaft
Abstract

Measured in terms of the cost of capital, the investment climate in Germany currently ranks 24th Key Messages out of the 28 EU member states. However, this represents an improvement over the year 2000, when Germany ranked 27th. In fact, among the EU-28, Germany has seen the most significant decline in the cost of capital between 2000 and 2014, from 7.7% to 6.5%. This decline is mainly attributable to considerable reductions in the country’s corporate tax rate. The comprehensive corporate tax reforms enacted in 2001 and 2008 thus appear to have succeeded in improving the investment climate in Germany. Nevertheless, in comparison to most other EU member states, the cost of capital in Germany is still quite high. In order to further improve the investment climate in Germany, the (temporary) re-introduction of reduced-balance tax depreciation for movable fixed assets is currently being discussed. However, our analysis indicates that this would only slightly decrease the cost of capital from 6.5% to 6.3%. When we additionally account for the personal taxation of individual investors, a different picture emerges: The overall cost of capital in Germany currently amounts to 6.0%, and could be reduced considerably by taxing dividends and capital gains at lower rates than interest income.

Published
2015

33. Fiscal investment climate and the cost of capital in Germany and the EU

Author

Evers, Lisa, Spengel, Christoph, and Braun, Julia

Subjects
330 Wirtschaft
Abstract

Ein vorrangiges Ziel der Europäischen Kommission besteht zurzeit darin, Anreize für private Investitionen in der EU zu schaffen. Die Wirksamkeit politischer Maßnahmen zur Stimulation privater Investitionen, wie zum Beispiel der kürzlich von Kommissionspräsident Jean-Claude Junker vorgeschlagene Europäische Fonds für strategische Investitionen, könnte jedoch durch ein ungünstiges Umfeld für Privatinvestitionen in einzelnen Mitgliedstaaten unterminiert werden. Vor allem die jeweiligen Steuersysteme könnten sich negativ auf private Investitionen auswirken. Kapitalkosten stellen eine wichtige Messgröße für die Bewertung des Einflusses der Besteuerung auf Investitionen dar. Kapitalkosten werden dabei verstanden als die erforderliche Mindestrendite vor Steuern einer unternehmerischen Investition, um nach Steuern der Rendite einer Alternativanlage am Kapitalmarkt zu entsprechen. Der vorliegende policy brief befasst sich mit folgenden drei Fragen: Wie schneidet das aktuelle steuerliche Investitionsklima in Deutschland mit Blick auf Kapitalkosten im EU-weiten Vergleich ab? Wie haben sich Kapitalkosten im Laufe der letzten 15 Jahre verändert? Wie würden sich derzeit diskutierte politische Maßnahmen (z. B. die Wiedereinführung der degressiven Abschreibung) auf die Kapitalkosten in Deutschland auswirken?

Published
2015

34. Intellectual Property (IP) box regimes : tax planning, effective tax burdens, and tax policy options

Author

Evers, Lisa

Subjects
ComputingMilieux_GENERAL, 330 Wirtschaft, Hardware_INTEGRATEDCIRCUITS, ComputingMilieux_LEGALASPECTSOFCOMPUTING, 340 Recht, Hardware_PERFORMANCEANDRELIABILITY
Abstract

This thesis contributes to the current debate on Intellectual Property (IP) Box regimes and IP tax planning. It provides a comprehensive survey of the 12 IP Box regimes in place in Europe by the end of 2014 and presents effective tax rates associated with the IP Box regimes and the use of popular tax planning models. Moreover, it evaluates the IP Box regimes on the basis of the EU State Aid rules and the EU Code of Conduct for business taxation and discusses options to reform the taxation of IP income in order to counter profit shifting and tax base erosion.

Published
2015

35. Effective tax rates under IP tax planning

Author

Evers, Lisa and Spengel, Christoph

Subjects
intangible assets, transfer pricing, 330 Wirtschaft, H25, K34, effective tax rate, intellectual property, profit shifting, contract R&D, ddc:330, F23, H32, H87, tax planning, corporate taxation
Abstract

Tax planning with intangibles has become one of the most popular and most vividly debated topics in international taxation. We incorporate various intellectual property (IP) tax planning models into forward-looking measures of effective tax rates, namely the disposal of intangibles to low-tax subsidiaries, intra-group licensing arrangements, and intra-group contract R&D. In doing so, we draw upon the methodology put forward by Devereux and Griffith and amend this model by considering a research & development (R&D) investment which is carried out by a parent company, whereby the resulting intangible is exploited by a foreign subsidiary. We point out analytically under which conditions IP tax planning achieves the objective of reducing the effective average tax rate of the group. We find that the disposal of intangibles to low-tax subsidiaries does not achieve this tax planning objective, if the true value of the asset is subject to tax upon the disposal. We show to what extent the parent must understate the value of the intangible in order to reduce the group's tax burden. We furthermore point out that contract R&D may generally achieve a significant lower effective tax burden. We present cost of capital and effect average tax rates to illustrate these findings.

Published
2014

36. Intellectual property box regimes : effective tax rates and tax policy considerations

Author

Evers, Lisa, Miller, Helen, and Spengel, Christoph

Subjects
tax incentive, innovation box, 330 Wirtschaft, H25, K34, tax incentive patent box, ComputingMilieux_LEGALASPECTSOFCOMPUTING, license box, effective tax rate, patent box, innovation, O38, ComputingMilieux_GENERAL, preferential tax rate, ddc:330, tax competition, H32, H87, corporate taxation
Abstract

11 European countries now operate IP Box regimes that provide substantially reduced rates of corporate tax for income derived from important forms of intellectual property. We incorporate these policies into forward-looking measures of the cost of capital, effective marginal tax rates and effective average tax rates. We show that the treatment of expenses relating to IP income is particularly important in determining the effective tax burden. A key finding is that regimes that allow expenses to be deducted at the ordinary corporate income tax rate, as opposed to the IP Box tax rate, may result in negative effective average tax rates and can thereby provide a subsidy to unprofitable projects. We assess the specific design features of different regimes against the possible policy aim of improving the incentives to undertake R&D investment in a country. While some countries have tried to tie the policy to real activities, others have designed a policy targeted at the income streams associated with intellectual property. A key concern is the role that IP Boxes may play in increased, and possibly harmful, tax competition between European countries.

Published
2013

37. Romania's development to a low-tax country - Effective Corporate Tax Burden in Romania from 1992 to 2010 and Romania's current ranking among the Eastern European Member States

Author

Spengel, Christoph, Lazar, Sebastian, Evers, Lisa, and Zinn, Benedikt

Subjects
effective tax burden, 330 Wirtschaft, H25, Steuerwirkung, Rumänien, O38, Steuerreform, Übergangswirtschaft, transition economy, Steuerbelastung, EU accession countries, tax-rate-cum-base-broadening reform, ddc:330, tax reform, H22, Unternehmensbesteuerung, corporate taxation, EU-Erweiterung
Abstract

We trace back Romania’s development to a low-tax country among the Member States of the European Union by analysing the major tax law changes in corporate taxation since 1992. We find that the significant reduction of the corporate income tax rate from 45% in 1992 to 16% since 2005 has not been accompanied by a comprehensive broadening of the corporate income tax base as prevalent in many longstanding Member States of the EU and the OECD. Our analysis is not limited to a comprehensive description of the development of corporate taxation in Romania, but goes on with a numerical analysis of the tax burdens at different periods of time which constitute milestones in the development of corporate taxation in Romania. For this purpose, we apply the European Tax Analyzer, which is a computer-based model firm approach. We find that the average company tax burden of the underlying model company has dropped significantly by almost 65% since 1992. Furthermore, our numerical analysis does not confirm the tax base broadening policy. As a result, Romania holds position two among the group of Central and Eastern European EU Member States.

Published
2012

38. Comment in response to the public consultation paper issued by the European Commission on 28th January 2011 on taxation problems that arise when dividends are distributed across borders to individual investors and possible solutions

Author

Spengel, Christoph and Evers, Lisa

Subjects
330 Wirtschaft
Abstract

The EU Commission identifies two major shortcomings of the cross‐border taxation of dividends received by portfolio shareholders in its consultation paper. Firstly, withholding taxes may be levied and credited in a discriminatory manner which may constitute an infringement of the free movement of capital set out in Articles 63 to 66 of the Treaty on the Functioning of the European Union. Secondly, the imposition of withholding taxes may result in double taxation and as a consequence impede investors from investing in foreign corporations. Hence, the benefits of international risk diversification are not fully exploited which may result in welfare losses.1 The parent‐subsidiary‐directive2 addresses this issue by prohibiting the imposition of dividends paid to substantial shareholdings. A comparable relief is, however, not available for portfolio and individual investors. In turn, withholding taxes on interest have been considerably reduced and even abolished by many member states whereas withholding taxes on dividends are still common and significant.3 This report therefore discusses how the above highlighted issues concerning the cross‐border taxation of dividends received by individuals can be resolved. The taxation of portfolio investments by corporations which is also left out of the scope of the parent‐subsidiary‐directive is not addressed in the following as this issue requires a separate analysis.

Published
2011

41. Abstract 1468: Characterization of patient-derived xenograft (PDX) models to evaluate clinical and therapeutic responses of glioblastoma multiforme

Author

Remonde, Dioval A., primary, Carlson, Brett L., additional, Schroeder, Mark A., additional, Armstrong, Brock, additional, Peng, Sen, additional, Evers, Lisa, additional, Decker, Paul A., additional, Eckel Passow, Jeanette, additional, Berens, Michael E., additional, Tran, Nhan L., additional, Jenkins, Robert B., additional, and Sarkaria, Jann N., additional

Published
2015
Full Text
View/download PDF

43. Auswirkungen von Steuervereinfachungen: Abschlussbericht Forschungsprojekt I C 4 - 18/10 im Auftrag des Bundesministeriums für Wirtschaft und Technologie

Author

Eichfelder, Sebastian, Evers, Lisa, Gläser, Sven Christian, Heinemann, Friedrich, Jenzen, Holger, Kalb, Alexander, and Misch, Florian

Subjects
Steuervereinfachung, Kosten, ddc:330, Wirkungsanalyse, Finanzverwaltung, Deutschland
Abstract

Das aktuelle budgetpolitische Umfeld bietet eine starke Motivation, Maßnahmen zur Steuervereinfachung in Angriff zu nehmen: Durch gezielte Maßnahmen zur Steuervereinfachung kann in vielen Fällen das Ziel einer wohlfahrts- und wachstumsfördernden Entlastung von Steuerzahlern verfolgt werden ohne dass dadurch notwendigerweise der Finanzierungsspielraum der öffentlichen Haushalte verringert wird. Vor diesem Hintergrund hat diese Studie eine doppelte Zielsetzung: erstens sollen aussichtsreiche und kurzfristig umsetzbare Maßnahmen der Steuervereinfachung identifiziert werden und zweitens sollen das Kosteneinsparungspotential und die Wirkungen eines solchen Maßnahmenpakets auf das gesamtwirtschaftliche Wachstum abgeschätzt werden. Der Analyse liegt dabei ein weiter Begriff der Kosten der Besteuerung zugrunde. Beru¨cksichtigt werden Kosten fu¨r private Haushalte, Unternehmen und die öffentliche Verwaltung. Unter den Kostenkategorien werden einbezogen: Planungs- oder Steuervermeidungskosten, da Steuerpflichtige ihr Verhalten mit dem Ziel, die Steuerbelastung zu minimieren, optimieren; Steuerbefolgungskosten, die den Steuerpflichtigen bei der Entrichtung der Steuerpflicht entstehen (beispielsweise durch die Sammlung und Aufbewahrung von Belegen oder die Berechnung der Bemessungsgrundlage) und Verwaltungskosten, die bei der Finanzverwaltung im Rahmen der Erhebung der Steuern und der Kontrolle der Steuerpflichtigen anfallen.

Published
2010

45. Whole Genome Analyses of a Well-Differentiated Liposarcoma Reveals Novel SYT1 and DDR2 Rearrangements

Author

Egan, Jan B., primary, Barrett, Michael T., additional, Champion, Mia D., additional, Middha, Sumit, additional, Lenkiewicz, Elizabeth, additional, Evers, Lisa, additional, Francis, Princy, additional, Schmidt, Jessica, additional, Shi, Chang-Xin, additional, Van Wier, Scott, additional, Badar, Sandra, additional, Ahmann, Gregory, additional, Kortuem, K. Martin, additional, Boczek, Nicole J., additional, Fonseca, Rafael, additional, Craig, David W., additional, Carpten, John D., additional, Borad, Mitesh J., additional, and Stewart, A. Keith, additional

Published
2014
Full Text
View/download PDF

47. Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes

Author

Stieber, Daniel, primary, Golebiewska, Anna, additional, Evers, Lisa, additional, Lenkiewicz, Elizabeth, additional, Brons, Nicolaas H. C., additional, Nicot, Nathalie, additional, Oudin, Anaïs, additional, Bougnaud, Sébastien, additional, Hertel, Frank, additional, Bjerkvig, Rolf, additional, Vallar, Laurent, additional, Barrett, Michael T., additional, and Niclou, Simone P., additional

Published
2013
Full Text
View/download PDF

49. Abstract 1911: Analysis of the pancreatic cancer (PC) genome by immunohistochemistry (IHC) and comparative genome hybridization (CGH) in patients with long term survival with metastatic disease (mPC) treated on a phase II molecular profiling trial.

Author

Shahda, Safi, primary, Barrett, Michael T., additional, Lenkiewicz, Elizabeth, additional, Evers, Lisa, additional, Posner, Richard G., additional, Aziz, Meraj, additional, Weiss, Glen J., additional, Jameson, Gayle, additional, Von Hoff, Daniel D., additional, and Ramanathan, Ramesh K., additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results