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1. The progression rate of aortic stenosis: key to tailoring the management and potential target for treatment

Author

Tafciu, E, Mandoli, Ge, Santoro, C, Setti, M, D'Andrea, A, Esposito, R, Bandera, F, Evola, V, Malagoli, A, Cameli, M, Benfari, G, dummy-AUTHOR_name, Working Group of Echocardiography of the Italian Society of Cardiology, Tafciu, E., Mandoli, G. E., Santoro, C., Setti, M., D'Andrea, A., Esposito, R., Bandera, F., Evola, V., Malagoli, A., Cameli, M., and Benfari, G.

Subjects
medicine.medical_specialty, progression rate, aortic stenosis, degenerative, progression rate, valvulopathies, 030204 cardiovascular system & hematology, Doppler echocardiography, 03 medical and health sciences, 0302 clinical medicine, Valvular disease, Risk Factors, medicine, Humans, degenerative, 030212 general & internal medicine, Heart valve, Intensive care medicine, medicine.diagnostic_test, business.industry, Disease progression, aortic stenosis, General Medicine, Aortic Valve Stenosis, medicine.disease, Prognosis, valvulopathies, Echocardiography, Doppler, Stenosis, medicine.anatomical_structure, Aortic valve stenosis, Disease Progression, Progression rate, Cardiology and Cardiovascular Medicine, business, Progressive disease
Abstract

Aortic stenosis is the most frequent valvular disease to require intervention in the western world and has always been featured as a progressive disease. The rate of progression can be assessed by carefully performed Doppler echocardiography and can vary greatly between individuals with a profound impact on prognosis. Unfortunately, the determinants of disease progression had been insufficiently studied and remain challenging to define, particularly in the outpatient setting. Multiple factors have been proposed and tested, but at present, there are no proven therapies to slow the course of the stenotic process. Heart valve clinics may be particularly important to define the progression rate and tailor follow-up and management at an individual level. This review enlightens knowledge and gaps regarding the progression-rate of aortic valve stenosis, from the historical perspective to the molecular one.

Published
2021

3. The eco-stress of the right heart-pulmonary circulation unit: rationale and application possibilities in clinical practice

Author

Sperlongano S., D'Andrea A., Mele D., Mandoli G. E., Sorrentino R., Esposito Roberta, Evola V., Bandera F., D'Alto M., Bossone E., Galderisi M., Cameli M., Sperlongano, S., D'Andrea, A., Mele, D., Mandoli, G. E., Sorrentino, R., Esposito, Roberta, Evola, V., Bandera, F., D'Alto, M., Bossone, E., Galderisi, M., and Cameli, M.

Subjects
Stress echocardiography, Pulmonary circulation, Right ventricle, Contractile reserve
Abstract

The right heart has been traditionally considered a passive conduit between the venous system and the lungs. Today, we know that a close hemodynamic interdependence exists between right ventricle, pulmonary circulation, and left ventricle, and that the right ventricle plays a key role in the ability to adapt to many super-physiological and pathological conditions. Dynamic exercise is a considerable stress for the "right heart-pulmonary circulation unit", which responds, in healthy subjects, with an increase of right ventricular contractility and cardiac output, a decrease of pulmonary vascular resistance, and a non-significant rise in pulmonary pressures. In patients affected by cardiac and/or pulmonary diseases (e.g. ischemic heart disease, heart failure, severe valvular stenosis or regurgitation, systemic sclerosis, chronic obstructive pulmonary disease, etc.) right ventricular contractile reserve may be impaired, and pulmonary artery systolic pressure may abnormally increase during exercise. From this perspective, stress echocardiography is a primary tool to evaluate right ventricle and pulmonary circulation during exercise, and can be useful in setting diagnosis, prognosis, and therapeutic timing of many cardiopulmonary diseases.

Published
2019

4. [Stress echocardiography of the righ heart-pulmonary circulation unit: rationale and possibilities of application in clinical practice]

Author

Sperlongano, S., D'Andrea, A., Mele, D., Mandoli, G. E., Sorrentino, R., Esposito, R., Evola, V., Bandera, F., D'Alto, M., Bossone, E., Galderisi, M., Cameli, M., Sperlongano, Simona, D'Andrea, Antonello, Mele, Donato, Mandoli, Giulia Elena, Sorrentino, Regina, Esposito, Roberta, Evola, Vincenzo, Bandera, Francesco, D'Alto, Michele, Bossone, Eduardo, Galderisi, Maurizio, and Cameli, Matteo

Subjects
Lung Diseases, Pulmonary Circulation, Contractile reserve, Pulmonary circulation, Right ventricle, Stress echocardiography, Echocardiography, Stress, Heart Diseases, Heart Ventricles, Humans, Prognosis, Prognosi, Stress, Lung Disease, Heart Ventricle, Heart Disease, Echocardiography, Echocardiography, Stre, Human
Abstract

The right heart has been traditionally considered a passive conduit between the venous system and the lungs. Today, we know that a close hemodynamic interdependence exists between right ventricle, pulmonary circulation, and left ventricle, and that the right ventricle plays a key role in the ability to adapt to many super-physiological and pathological conditions. Dynamic exercise is a considerable stress for the "right heart-pulmonary circulation unit", which responds, in healthy subjects, with an increase of right ventricular contractility and cardiac output, a decrease of pulmonary vascular resistance, and a non-significant rise in pulmonary pressures. In patients affected by cardiac and/or pulmonary diseases (e.g. ischemic heart disease, heart failure, severe valvular stenosis or regurgitation, systemic sclerosis, chronic obstructive pulmonary disease, etc.) right ventricular contractile reserve may be impaired, and pulmonary artery systolic pressure may abnormally increase during exercise. From this perspective, stress echocardiography is a primary tool to evaluate right ventricle and pulmonary circulation during exercise, and can be useful in setting diagnosis, prognosis, and therapeutic timing of many cardiopulmonary diseases.

Published
2019

6. The relationship between endothlial ABD erectile dysfunction, levels of testosterone and cardiovascular events in the follow-up

Author

NOVO, Salvatore, Bonomo, V, Iacona, R, Evola, V, CORRADO, Egle, Di Piazza, M, NOVO, Giuseppina, PAVONE, Carlo, Novo, S, Bonomo, V, Iacona, R, Evola, V, Corrado, E, Di Piazza, M, Novo, G, and Pavone, C

Subjects
testosterone levels, endothelial function, erectile dysfunction, cardiovascular risk, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Settore MED/24 - Urologia
Abstract

Background: Clinical and experimental evidence suggest that testosterone levels play a role in cardiac and vascular pathology. A long history of observational studies investigating serum testosterone level and cardiovascular risks, specifically mortality, reveals important associations between low testosterone and mortality, while higher serum testosterone level appear to be predictive in the majority of studies. On the other hand, it is well documented and accepted that endothelial dysfunction is expression of preclinical atherosclerosis and it is associated with an increased amount of CV events in the follow-up. Erectile dysfunction is also an early manifestation of arteriosclerosis associated with endothelial damage/dysfunction. Endothelial function plays a very important role in the process of erection. Moreover, erectile dysfunction and coronary artery disease (CAD) overlap in risk factors, etiology and clinical outcomes. Endothelial dysfunction is considered to be their shared etiological factor. There is growing evidence that patients presenting with erectile dysfunction should be investigated for CAD, even if with no symptoms of the problem. Earlier diagnosis of erectile dysfunction can facilitate prompt intervention, reduce long-term complications, especially the risk of CAD, and provide effective treatment for erectile dysfunction. Objectives: We aimed to assess whether baseline testosterone levels may be predictors of future CV events in a cohort of patients at intermediate cardiovascular risk. Methods: Our cohort included 802 adult subjects, males from 40 to 80 years (mean age of the whole population was 57.52±13.85 years old). Thy were at intermediate cardiovascular risk, according to the Framingham risk score and all referred between 2009 and 2014. Patients were excluded if they had a past history of peripheral artery disease, coronary revascularization, angina pectoris, myocardial infarction, carotid surgery or cerebrovascular event. The study of the endothelial function was performed by using the method of flow mediated vasodilation. Moreover, it was administered a standard questionnaire for the evaluation of the erectile function and the dosage of the plasma testosterone was carried out. The median follow-up time for major CV events was 5.1 years. Results: Patients with lower serum testosterone levels (n=332) had a higher prevalence of traditional CV risk factors, such as hypertension (p=0.009), diabetes (p=0.03), dyslipidemia (p

Published
2016

7. Poster session 4: Friday 5 December 2014, 08:30-12:30Location: Poster area

Author

Orii M, Tanimoto T, Yokoyama M, Ota S, Kubo T, Hirata K, Tanaka A, Imanishi T, Akasaka T, Michelsen M, Pena A, Mygind N, Hoest N, Prescott E, Abd El Dayem S, Battah A, Abd El Azzez F, Ahmed A, Fattoh A, Ismail R, Andjelkovic K, Kalimanovska Ostric D, Nedeljkovic I, Andjelkovic I, Rashid H, Abuel Enien H, Ibraheem M, Vago H, Toth A, Csecs I, Czimbalmos C, Suhai FI, Kecskes K, Becker D, Simor T, Merkely B, D'ascenzi F, Pelliccia A, Natali B, Cameli M, Lisi M, Focardi M, Corrado D, Bonifazi M, Mondillo S, Zaha V, Kim G, Su K, Zhang J, Mikush N, Ross J, Palmeri M, Young L, Tadic M, Ilic S, Celic V, Jaimes C, Gonzalez Mirelis J, Gallego M, Goirigolzarri J, Pellegrinet M, Poli S, Prati G, Vriz O, Di Bello V, Carerj S, Zito C, Mateescu A, Popescu B, Antonini Canterin F, Chatzistamatiou E, Moustakas G, Memo G, Konstantinidis D, Mpampatzeva Vagena I, Manakos K, Traxanas K, Vergi N, Feretou A, Kallikazaros I, Hewing B, Theres L, Dreger H, Spethmann S, Stangl K, Baumann G, Knebel F, Uejima T, Itatani K, Nakatani S, Lancellotti P, Seo Y, Zamorano J, Ohte N, Takenaka K, Naar J, Mortensen L, Johnson J, Winter R, Shahgaldi K, Manouras A, Braunschweig F, Stahlberg M, Coisne D, Al Arnaout AM, Tchepkou C, Raud Raynier P, Diakov C, Degand B, Christiaens L, Barbier P, Mirea O, Cefalu C, Savioli G, Guglielmo M, Maltagliati A, O'neill L, Walsh K, Hogan J, Manzoor T, Ahern B, Owens P, Sengelov M, Biering Sorensen T, Jorgensen P, Bruun N, Fritz Hansen T, Bech J, Olsen F, Sivertsen J, Jensen J, Marta L, Abecasis J, Reis C, Ribeiras R, Andrade M, Mendes M, D'andrea A, Stanziola A, Di Palma E, Martino M, Lanza M, Betancourt V, Maglione M, Calabro' R, Russo M, Bossone E, Vogt MO, Meierhofer Ch, Rutz T, Fratz S, Ewert P, Roehlig Ch, Kuehn A, Storsten P, Eriksen M, Remme E, Boe E, Smiseth O, Skulstad H, Ereminiene E, Ordiene R, Ivanauskas V, Vaskelyte J, Stoskute N, Kazakauskaite E, Benetis R, Marketou M, Parthenakis F, Kontaraki J, Zacharis E, Maragkoudakis S, Logakis J, Roufas K, Vougia D, Vardas P, Dado E, Knuti G, Djamandi J, Shota E, Sharka I, Saka J, Halmai L, Nemes A, Kardos A, Neubauer S, Kurnicka K, Domienik Karlowicz J, Lichodziejewska B, Goliszek S, Grudzka K, Krupa M, Dzikowska Diduch O, Ciurzynski M, Pruszczyk P, Chung H, Kim J, Yoon Y, Min P, Lee B, Hong B, Rim S, Kwon H, Choi E, Soya O, Kuryata O, Kakihara R, Naruse C, Inayoshi A, El Sebaie M, Frer A, Abdelsamie M, Eldamanhory A, Ciampi Q, Cortigiani L, Simioniuc A, Manicardi C, Villari B, Picano E, Sicari R, Ferferieva V, Deluyker D, Lambrichts I, Rigo J, Bito V, Kuznetsov V, Yaroslavskaya E, Krinochkin D, Pushkarev G, Gorbatenko E, Trzcinski P, Michalski B, Lipiec P, Szymczyk E, Peczek L, Nawrot B, Chrzanowski L, Kasprzak J, Todaro M, Khandheria B, Cusma Piccione M, La Carrubba S, Oreto G, Di Bella G, Gunyeli E, Oliveira Da Silva C, Sahlen A, Spampinato R, Tasca M, Roche E. Silva J, Strotdrees E, Schloma V, Dmitrieva Y, Dobrovie M, Borger M, Mohr F, Einarsen E, Cramariuc D, Lonnebakken M, Boman K, Gohlke Barwolf C, Chambers J, Gerdts E, Calin A, Rosca M, Beladan C, Mirescu Craciun A, Gurzun M, Enache R, Ginghina C, Antova E, Georgievska Ismail Lj, Srbinovska E, Andova V, Peovska I, Davceva J, Otljanska M, Vavulkis M, Tsuruta H, Kohsaka S, Murata M, Yasuda R, Dan M, Yashima F, Inohara T, Maekawa Y, Hayashida K, Fukuda K, Migliore R, Adaniya M, Barranco M, Miramont G, Gonzalez S, Tamagusuku H, Abid L, Ben Kahla S, Charfeddine S, Abid D, Kammoun S, Amano M, Izumi C, Miyake M, Tamura T, Kondo H, Kaitani K, Nakagawa Y, Ghulam Ali S, Fusini L, Tamborini G, Muratori M, Gripari P, Bottari V, Celeste F, Cefalu' C, Alamanni F, Pepi M, Obase K, Mor Avi V, Weinert L, Lang R, Teixeira R, Monteiro R, Garcia J, Ribeiro M, Cardim N, Goncalves L, Miglioranza M, Muraru D, Cavalli G, Addetia K, Cucchini U, Mihaila S, Veronesi F, Badano L, Galian Gay L, Gonzalez Alujas M, Teixido Tura G, Gutierrez Garcia L, Rodriguez Palomares J, Evangelista Masip A, Conte L, Fabiani I, Giannini C, La Carruba S, De Carlo M, Barletta V, Petronio A, Mahmoud H, Al Ghamdi M, Ghabashi A, Salaun E, Zenses A, Evin M, Collart F, Pibarot P, Habib G, Rieu R, Fabregat Andres O, Estornell Erill J, Cubillos Arango A, Bochard Villanueva B, Chacon Hernandez N, Higueras Ortega L, Perez Bosca L, Paya Serrano R, Ridocci Soriano F, Cortijo Gimeno J, Mzoughi K, Zairi I, Jabeur M, Ben Moussa F, Mrabet K, Kamoun S, Fennira S, Ben Chaabene A, Kraiem S, Schnell F, Betancur J, Daudin M, Simon A, Lentz P, Tavard F, Hernandes A, Carre F, Garreau M, Donal E, Abduch M, Vieira M, Antunes M, Mathias W, Mady C, Arteaga E, Alencar A, Tesic M, Djordjevic Dikic A, Beleslin B, Giga V, Trifunovic D, Petrovic O, Jovanovic I, Petrovic M, Stepanovic J, Vujisic Tesic B, Cha J, Kim Kh, Bergler Klein J, Geier C, Maurer G, Gyongyosi M, Cortes Garcia M, Oliva M, Navas M, Orejas M, Rabago R, Martinez M, Briongos S, Romero A, Rey M, Farre J, Ruisanchez Villar C, Ruiz Guerrero L, Rubio Ruiz S, Lerena Saenz P, Gonzalez Vilchez F, Hernandez Hernandez J, Armesto Alonso S, Blanco Alonso R, Martin Duran R, Gonzalez Gay M, Novo G, Marturana I, Bonomo V, Arvigo L, Evola V, Karfakis G, Lo Presti M, Verga S, Novo S, Petroni R, Acitelli A, Bencivenga S, Cicconetti M, Di Mauro M, Petroni A, Romano S, Penco M, Park S, Kim S, Kim M, Shim W, Majstorovic A, Ivanovic B, Driessen MM, Meijboom F, Mertens L, Dragulescu A, Friedberg M, De Stefano F, Santoro C, Buonauro A, Muscariello R, Lo Iudice F, Ierano P, Esposito R, Galderisi M, Sunbul M, Kivrak T, Durmus E, Yildizeli B, Mutlu B, Rodrigues A, Daminello E, Echenique L, Cordovil A, Oliveira W, Monaco Ch, Lira E, Fischer Ch, Morhy S, Mignot A, Jaussaud J, Chevalier L, Lafitte S, Curci V, Alvino F, Ikonomidis I, Pavlidis G, Lambadiari V, Kousathana F, Triantafyllidi H, Varoudi M, Dimitriadis G, Lekakis J, Cho JS, Cho E, Yoon H, Ihm Sh, Lee J, Molnar AA, Kovacs A, Apor A, Tarnoki A, Tarnoki D, Horvath T, Maurovich Horvat P, Jermendy G, Kiss R, Al Habbaa A, Petrovic Nagorni S, Ciric Zdravkovic S, Stanojevic D, Jankovic Tomasevic R, Atanaskovic V, Mitic V, Todorovic L, Dakic S, Park JS, Choi J, Kim Sh, Kwon Y, Jin H, Coppola C, Piscopo G, Galletta F, Maurea C, Esposito E, Barbieri A, Maurea N, Kaldararova M, Tittel P, Kantorova A, Vrsanska V, Kollarova E, Hraska V, Nosal M, Ondriska M, Masura J, Simkova I, Tadeu I, Azevedo O, Lourenco M, Luis F, Lourenco A, Planinc I, Bagadur G, Bijnens B, Ljubas J, Baricevic Z, Skoric B, Velagic V, Milicic D, Cikes M, Campanale CM, Di Maria S, Mega S, Nusca A, Marullo F, Di Sciascio G, El Tahlawi M, Abdallah M, Gouda M, Gad M, Elawady M, Igual Munoz B, Maceira Gonzalez Alicia A, Donate Betolin L, Vazquez Sanchez Alejandro A, Valera Martinez F, Sepulveda Sanchez P, Cervera Zamora A, Piquer Gil Marina M, Montero Argudo A, Naka K, Evangelou D, Lakkas L, Kalaitzidis R, Bechlioulis A, Gkirdis I, Tzeltzes G, Nakas G, Pappas K, Michalis L, Mansencal N, Bagate F, Arslan M, Siam Tsieu V, Deblaise J, El Mahmoud R, Dubourg O, Wierzbowska Drabik K, Plewka M, Bandera F, Generati G, Pellegrino M, Alfonzetti E, Labate V, Villani S, Gaeta M, Guazzi M, Grycewicz T, Szymanska K, Grabowicz W, Lubinski A, Sotaquira M, Caiani E, Garcia Gonzalez P, De La Espriella Juan R, Albiach Montanana C, Berenguer Jofresa A, Perez Bosca J, Cheng HL, Huang CH, Wang YC, Chou WH, Melnikov N, Kolunin G, Enina T, Sierraalta W, Le Bihan D, Barretto R, Assef J, Gospos M, Buffon M, Ramos A, Garcia A, Pinto I, Souza A, Mueller H, Reverdin S, Ehret G, Conti L, Dos Santos S, Abdel Moneim SS, Nhola LF, Huang R, Kohli M, Longenbach S, Green M, Villarraga HR, Bordun KA, Jassal DS, Mulvagh SL, Evangelista A, Madeo A, Piras P, Giordano F, Giura G, Teresi L, Gabriele S, Re F, Puddu P, Torromeo C, Suwannaphong S, Vathesatogkit P, See O, Yamwong S, Katekao W, Sritara P, Iliuta L, Szulik M, Streb W, Wozniak A, Lenarczyk R, Sliwinska A, Kalarus Z, Kukulski T, Weng KP, Lin CC, Hein S, Lehmann L, Kossack M, Juergensen L, Katus H, Hassel D, Turrini F, Scarlini S, Giovanardi P, Messora R, Mannucci C, Bondi M, Olander R, Sundholm J, Ojala T, Andersson S, Sarkola T, Karolyi M, Kocsmar I, Raaijmakers R, Kitslaar P, Szilveszter B, Tissue Doppler echocardiography research work, VFM international collaboration group, MTA SE Lendület Cardiovascular Imaging Research Group Heart, Vascular Center Semmelweis University Budapest Hungary, POLICINO, SALVATORE, Orii, M, Tanimoto, T, Yokoyama, M, Ota, S, Kubo, T, Hirata, K, Tanaka, A, Imanishi, T, Akasaka, T, Michelsen, M, Pena, A, Mygind, N, Hoest, N, Prescott, E, Abd El Dayem, S, Battah, A, Abd El Azzez, F, Ahmed, A, Fattoh, A, Ismail, R, Andjelkovic, K, Kalimanovska Ostric, D, Nedeljkovic, I, Andjelkovic, I, Rashid, H, Abuel Enien, H, Ibraheem, M, Vago, H, Toth, A, Csecs, I, Czimbalmos, C, Suhai, Fi, Kecskes, K, Becker, D, Simor, T, Merkely, B, D'Ascenzi, F, Pelliccia, A, Natali, B, Cameli, M, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Zaha, V, Kim, G, Su, K, Zhang, J, Mikush, N, Ross, J, Palmeri, M, Young, L, Tadic, M, Ilic, S, Celic, V, Jaimes, C, Gonzalez Mirelis, J, Gallego, M, Goirigolzarri, J, Pellegrinet, M, Poli, S, Prati, G, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Mateescu, A, Popescu, B, Antonini Canterin, F, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Hewing, B, Theres, L, Dreger, H, Spethmann, S, Stangl, K, Baumann, G, Knebel, F, Uejima, T, Itatani, K, Nakatani, S, Lancellotti, P, Seo, Y, Zamorano, J, Ohte, N, Takenaka, K, Naar, J, Mortensen, L, Johnson, J, Winter, R, Shahgaldi, K, Manouras, A, Braunschweig, F, Stahlberg, M, Coisne, D, Al Arnaout, Am, Tchepkou, C, Raud Raynier, P, Diakov, C, Degand, B, Christiaens, L, Barbier, P, Mirea, O, Cefalu, C, Savioli, G, Guglielmo, M, Maltagliati, A, O'Neill, L, Walsh, K, Hogan, J, Manzoor, T, Ahern, B, Owens, P, Sengelov, M, Biering Sorensen, T, Jorgensen, P, Bruun, N, Fritz Hansen, T, Bech, J, Olsen, F, Sivertsen, J, Jensen, J, Marta, L, Abecasis, J, Reis, C, Ribeiras, R, Andrade, M, Mendes, M, D'Andrea, A, Stanziola, A, Di Palma, E, Martino, M, Lanza, M, Betancourt, V, Maglione, M, Calabro', R, Russo, M, Bossone, E, Vogt, Mo, Meierhofer, Ch, Rutz, T, Fratz, S, Ewert, P, Roehlig, Ch, Kuehn, A, Storsten, P, Eriksen, M, Remme, E, Boe, E, Smiseth, O, Skulstad, H, Ereminiene, E, Ordiene, R, Ivanauskas, V, Vaskelyte, J, Stoskute, N, Kazakauskaite, E, Benetis, R, Marketou, M, Parthenakis, F, Kontaraki, J, Zacharis, E, Maragkoudakis, S, Logakis, J, Roufas, K, Vougia, D, Vardas, P, Dado, E, Knuti, G, Djamandi, J, Shota, E, Sharka, I, Saka, J, Halmai, L, Nemes, A, Kardos, A, Neubauer, S, Kurnicka, K, Domienik Karlowicz, J, Lichodziejewska, B, Goliszek, S, Grudzka, K, Krupa, M, Dzikowska Diduch, O, Ciurzynski, M, Pruszczyk, P, Chung, H, Kim, J, Yoon, Y, Min, P, Lee, B, Hong, B, Rim, S, Kwon, H, Choi, E, Soya, O, Kuryata, O, Kakihara, R, Naruse, C, Inayoshi, A, El Sebaie, M, Frer, A, Abdelsamie, M, Eldamanhory, A, Ciampi, Q, Cortigiani, L, Simioniuc, A, Manicardi, C, Villari, B, Picano, E, Sicari, R, Ferferieva, V, Deluyker, D, Lambrichts, I, Rigo, J, Bito, V, Kuznetsov, V, Yaroslavskaya, E, Krinochkin, D, Pushkarev, G, Gorbatenko, E, Trzcinski, P, Michalski, B, Lipiec, P, Szymczyk, E, Peczek, L, Nawrot, B, Chrzanowski, L, Kasprzak, J, Todaro, M, Khandheria, B, Cusma Piccione, M, La Carrubba, S, Oreto, G, Di Bella, G, Gunyeli, E, Oliveira Da Silva, C, Sahlen, A, Spampinato, R, Tasca, M, Roche E., Silva J, Strotdrees, E, Schloma, V, Dmitrieva, Y, Dobrovie, M, Borger, M, Mohr, F, Einarsen, E, Cramariuc, D, Lonnebakken, M, Boman, K, Gohlke Barwolf, C, Chambers, J, Gerdts, E, Calin, A, Rosca, M, Beladan, C, Mirescu Craciun, A, Gurzun, M, Enache, R, Ginghina, C, Antova, E, Georgievska Ismail, Lj, Srbinovska, E, Andova, V, Peovska, I, Davceva, J, Otljanska, M, Vavulkis, M, Tsuruta, H, Kohsaka, S, Murata, M, Yasuda, R, Dan, M, Yashima, F, Inohara, T, Maekawa, Y, Hayashida, K, Fukuda, K, Migliore, R, Adaniya, M, Barranco, M, Miramont, G, Gonzalez, S, Tamagusuku, H, Abid, L, Ben Kahla, S, Charfeddine, S, Abid, D, Kammoun, S, Amano, M, Izumi, C, Miyake, M, Tamura, T, Kondo, H, Kaitani, K, Nakagawa, Y, Ghulam Ali, S, Fusini, L, Tamborini, G, Muratori, M, Gripari, P, Bottari, V, Celeste, F, Cefalu', C, Alamanni, F, Pepi, M, Obase, K, Mor Avi, V, Weinert, L, Lang, R, Teixeira, R, Monteiro, R, Garcia, J, Ribeiro, M, Cardim, N, Goncalves, L, Miglioranza, M, Muraru, D, Cavalli, G, Addetia, K, Cucchini, U, Mihaila, S, Veronesi, F, Badano, L, Galian Gay, L, Gonzalez Alujas, M, Teixido Tura, G, Gutierrez Garcia, L, Rodriguez Palomares, J, Evangelista Masip, A, Conte, L, Fabiani, I, Giannini, C, La Carruba, S, De Carlo, M, Barletta, V, Petronio, A, Mahmoud, H, Al Ghamdi, M, Ghabashi, A, Salaun, E, Zenses, A, Evin, M, Collart, F, Pibarot, P, Habib, G, Rieu, R, Fabregat Andres, O, Estornell Erill, J, Cubillos Arango, A, Bochard Villanueva, B, Chacon Hernandez, N, Higueras Ortega, L, Perez Bosca, L, Paya Serrano, R, Ridocci Soriano, F, Cortijo Gimeno, J, Mzoughi, K, Zairi, I, Jabeur, M, Ben Moussa, F, Mrabet, K, Kamoun, S, Fennira, S, Ben Chaabene, A, Kraiem, S, Schnell, F, Betancur, J, Daudin, M, Simon, A, Lentz, P, Tavard, F, Hernandes, A, Carre, F, Garreau, M, Donal, E, Abduch, M, Vieira, M, Antunes, M, Mathias, W, Mady, C, Arteaga, E, Alencar, A, Tesic, M, Djordjevic Dikic, A, Beleslin, B, Giga, V, Trifunovic, D, Petrovic, O, Jovanovic, I, Petrovic, M, Stepanovic, J, Vujisic Tesic, B, Cha, J, Kim, Kh, Bergler Klein, J, Geier, C, Maurer, G, Gyongyosi, M, Cortes Garcia, M, Oliva, M, Navas, M, Orejas, M, Rabago, R, Martinez, M, Briongos, S, Romero, A, Rey, M, Farre, J, Ruisanchez Villar, C, Ruiz Guerrero, L, Rubio Ruiz, S, Lerena Saenz, P, Gonzalez Vilchez, F, Hernandez Hernandez, J, Armesto Alonso, S, Blanco Alonso, R, Martin Duran, R, Gonzalez Gay, M, Novo, G, Marturana, I, Bonomo, V, Arvigo, L, Evola, V, Karfakis, G, Lo Presti, M, Verga, S, Novo, S, Petroni, R, Acitelli, A, Bencivenga, S, Cicconetti, M, Di Mauro, M, Petroni, A, Romano, S, Penco, M, Park, S, Kim, S, Kim, M, Shim, W, Majstorovic, A, Ivanovic, B, Driessen, Mm, Meijboom, F, Mertens, L, Dragulescu, A, Friedberg, M, De Stefano, F, Santoro, C, Buonauro, A, Muscariello, R, Lo Iudice, F, Ierano, P, Esposito, R, Galderisi, M, Sunbul, M, Kivrak, T, Durmus, E, Yildizeli, B, Mutlu, B, Rodrigues, A, Daminello, E, Echenique, L, Cordovil, A, Oliveira, W, Monaco, Ch, Lira, E, Fischer, Ch, Morhy, S, Mignot, A, Jaussaud, J, Chevalier, L, Lafitte, S, Curci, V, Alvino, F, Ikonomidis, I, Pavlidis, G, Lambadiari, V, Kousathana, F, Triantafyllidi, H, Varoudi, M, Dimitriadis, G, Lekakis, J, Cho, J, Cho, E, Yoon, H, Ihm, Sh, Lee, J, Molnar, Aa, Kovacs, A, Apor, A, Tarnoki, A, Tarnoki, D, Horvath, T, Maurovich Horvat, P, Jermendy, G, Kiss, R, Al Habbaa, A, Petrovic Nagorni, S, Ciric Zdravkovic, S, Stanojevic, D, Jankovic Tomasevic, R, Atanaskovic, V, Mitic, V, Todorovic, L, Dakic, S, Park, J, Choi, J, Kim, Sh, Kwon, Y, Jin, H, Coppola, C, Piscopo, G, Galletta, F, Maurea, C, Esposito, E, Barbieri, A, Maurea, N, Kaldararova, M, Tittel, P, Kantorova, A, Vrsanska, V, Kollarova, E, Hraska, V, Nosal, M, Ondriska, M, Masura, J, Simkova, I, Tadeu, I, Azevedo, O, Lourenco, M, Luis, F, Lourenco, A, Planinc, I, Bagadur, G, Bijnens, B, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Milicic, D, Cikes, M, Campanale, Cm, Di Maria, S, Mega, S, Nusca, A, Marullo, F, Di Sciascio, G, El Tahlawi, M, Abdallah, M, Gouda, M, Gad, M, Elawady, M, Igual Munoz, B, Maceira Gonzalez Alicia, A, Donate Betolin, L, Vazquez Sanchez Alejandro, A, Valera Martinez, F, Sepulveda Sanchez, P, Cervera Zamora, A, Piquer Gil Marina, M, Montero Argudo, A, Naka, K, Evangelou, D, Lakkas, L, Kalaitzidis, R, Bechlioulis, A, Gkirdis, I, Tzeltzes, G, Nakas, G, Pappas, K, Michalis, L, Mansencal, N, Bagate, F, Arslan, M, Siam Tsieu, V, Deblaise, J, El Mahmoud, R, Dubourg, O, Wierzbowska Drabik, K, Plewka, M, Bandera, F, Generati, G, Pellegrino, M, Alfonzetti, E, Labate, V, Villani, S, Gaeta, M, Guazzi, M, Grycewicz, T, Szymanska, K, Grabowicz, W, Lubinski, A, Sotaquira, M, Caiani, E, Garcia Gonzalez, P, De La Espriella Juan, R, Albiach Montanana, C, Berenguer Jofresa, A, Perez Bosca, J, Cheng, Hl, Huang, Ch, Wang, Yc, Chou, Wh, Melnikov, N, Kolunin, G, Enina, T, Sierraalta, W, Le Bihan, D, Barretto, R, Assef, J, Gospos, M, Buffon, M, Ramos, A, Garcia, A, Pinto, I, Souza, A, Mueller, H, Reverdin, S, Ehret, G, Conti, L, Dos Santos, S, Abdel Moneim, S, Nhola, Lf, Huang, R, Kohli, M, Longenbach, S, Green, M, Villarraga, Hr, Bordun, Ka, Jassal, D, Mulvagh, Sl, Evangelista, A, Madeo, A, Piras, P, Giordano, F, Giura, G, Teresi, L, Gabriele, S, Re, F, Puddu, P, Torromeo, C, Suwannaphong, S, Vathesatogkit, P, See, O, Yamwong, S, Katekao, W, Sritara, P, Iliuta, L, Szulik, M, Streb, W, Wozniak, A, Lenarczyk, R, Sliwinska, A, Kalarus, Z, Kukulski, T, Weng, Kp, Lin, Cc, Hein, S, Lehmann, L, Kossack, M, Juergensen, L, Katus, H, Hassel, D, Turrini, F, Scarlini, S, Giovanardi, P, Messora, R, Mannucci, C, Bondi, M, Olander, R, Sundholm, J, Ojala, T, Andersson, S, Sarkola, T, Karolyi, M, Kocsmar, I, Raaijmakers, R, Kitslaar, P, Szilveszter, B, Tissue Doppler echocardiography research, Work, VFM international collaboration, Group, MTA SE Lendület Cardiovascular Imaging Research Group, Heart, Vascular Center Semmelweis University Budapest, Hungary, and Policino, Salvatore

Subjects
Medical education, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Friday 5 December 2014, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2014

8. Relazione tra disfunzione erettile, livelli di testosterone e funzione endoteliale in pazienti a rischio cardiovascolare intermedio secondo le stime della Carta di Framingham' – P259

Author

PAVONE, Carlo, NOVO, Giuseppina, NOVO, Salvatore, Iacona, R, Bonomo, V, Evola, V, Di Piazza, M, Corrado, E, Pavone, C, Iacona, R, Bonomo, V, Evola, V, Di Piazza, M, Corrado, E, Novo, G, and Novo, S

Subjects
Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, DE, testesterone plasmatico, Settore MED/24 - Urologia
Abstract

Scopo del lavoro Il ruolo dei livelli di testosterone plasmatico e della disfunzione erettile come marcatori precoci di disfunzione endoteliale non è ben definito. Pertanto, abbiamo cercato di analizzare la relazione tra testosterone plasmatico e disfunzione erettile, in rapporto alla funzione endoteliale. Materiali e metodi Abbiamo quindi arruolato 802 pazienti in prevenzione primaria, con una stima di rischio cardiovascolare (CV) intermedio secondo la carta del rischio di Framingham, di età compresa fra 40 e 80 anni, che si sono sottoposti all’esame ecografico della dilatazione flusso mediata dell’arteria brachiale destra, alla valutazione della disfunzione erettile attraverso il questionario International index of erectile function-5 score (IIEF-5) , e al dosaggio dei livelli plasmatici di testosterone totale. Risultati All’analisi di regressione lineare, con l’aumentare dei livelli di testosterone, aumentavano in maniera statisticamente significativa sia la funzione endoteliale (t=9.40; 95% CI da 0.9318 a 1.4234; p < 0.0001) che la funzione erettile (t=8.96; 95% CI da 0.7642 a 1.1932; p< 0,001) sia con la disfunzione erettile severa (OR 0,78; CI 0,62 -0,86), e moderata (OR 0,85; CI 0,72 - 0,97) che con una peggiore funzione endoteliale [(OR 0,68; CI 0,59- 0,79) e (OR 0,76; CI 0,63 - 0,83) rispettivamente]. Invece, le forme più sfumate di disfunzione erettile come quella lieve (OR 0.94; CI 0.82 - 1.07; p=0.03) e lieve-moderata (OR 0,8; CI 0,69 - 0,94; p Discussione Abbiamo quindi dimostrato una correlazione significativa tra livelli più bassi di testosterone plasmatico totale, disfunzione erettile ed una peggiore funzione endoteliale in una popolazione di soggetti asintomatici e a rischio CV intermedio. In particolar modo, nel sottogruppo di pazienti con disfunzione erettile moderatasevera, abbiamo visto che coloro che hanno livelli più bassi di testosterone hanno anche delle percentuali di dilatazione flusso mediata inferiori, e quindi una peggiore funzione endoteliale. Conclusioni Sulla base di questi risultati, consigliamo la valutazione della disfunzione erettile attraverso l’IIEF-5, e il dosaggio dei livelli di testosterone totale plasmatico, per ottenere una stratificazione più accurata del rischio CV nei pazienti asintomatici, ma con rischio intermedio secondo le stime della carta di Framingham.

Published
2014

12. Metafora

Author

Casonato, M, Evola, V, CASONATO, MARCO MARIO, Evola, V., Casonato, M, Evola, V, CASONATO, MARCO MARIO, and Evola, V.

Published
2010

13. Metafora

Author

CASONATO, MARCO MARIO, Evola, V., Casonato, M, and Evola, V

Subjects
Metafora, Analogia, Clinica
Published
2010

15. “Io sono evoluto e quello è un uomo di Neanderthal”: Un’analisi linguistica cognitivista del concetto di evoluzione

Author

Evola, Vito

Subjects
Psychology: Psycholinguistics, Linguistics: Pragmatics, Biology: Evolution, Philosophy: Philosophy of Mind, Linguistics: Semantics, Philosophy: Philosophy of Science, Psychology: Social Psychology, Psychology: Cognitive Psychology, Biology: Theoretical Biology, Philosophy: Philosophy of Language, Psycholinguistics, Pragmatics, Evolution, Philosophy of Mind, Semantics, Philosophy of Science, Social Psychology, Cognitive Psychology, Theoretical Biology, Philosophy of Language
Abstract

“Evoluzione” è una parola usata ormai frequentemente dall’uomo comune nonché in tutte le discipline, umanistiche e scientifiche. Culturalmente radicata, è diventata una metafora potente. Una definizione corrente è “sviluppo lento e graduale; svolgimento da una forma a un’altra, generalmente più completa e perfetta” (Garzanti). In questi termini non si parla soltanto dell’evoluzione biologica dell’uomo, ma anche dell’evoluzione del linguaggio, della società, della cognizione umana – a prescindere da un’effettiva conoscenza delle teorie evoluzionistiche. L’evoluzione, in quanto teoria biologica, rimanda quasi automaticamente alla teoria di Darwin, il quale, tuttavia, ha usato il termine solo una volta, nel paragrafo finale del suo celeberrimo L’origine delle specie (1859). Nel concetto di evoluzione è comunemente implicato il passaggio da una specie “primitiva” ad una specie “progredita”, più avanzata o sofisticata e strutturalmente più complessa. Nei suoi scritti, Darwin preferiva parlare di “discendenza con modificazioni” anziché di “evoluzione”, termine usato invece da Bonnet (1762) nella sua teoria dell’homunculus, proprio perché portatore della valenza semantica di “progresso”, non presente nella teoria che Darwin proponeva. Infatti, per quest’ultimo “evoluzione” ha più a che fare con il cambiamento (x --> y) che con il progresso (x --> x+1). L’idea che il concetto di evoluzione abbia a che fare con quello di progresso è in realtà posteriore: nell’accezione più comune del termine è presente l’idea di una temporalità lineare, nella quale l’hic et nunc è visto come la massima compiutezza dello sviluppo, della complessità e della “modernità”, e il passato è visto da un punto di vista situato in un setting storico del presente (antropo-, etno-, euro-, ego-centrico etc), in un’opposizione binaria tra “adesso” e “allora”, tra “noi” e “loro”, tra “progredito” e “primitivo”. Eppure l’evoluzione, in senso stretto, non è teleologica e non c’è un “avanti” o un “indietro”, c’è solo un cambiamento causato dall’adattamento nell’ecosistema in cui l’essere storico si trova. Evoluzione non è necessariamente sinonimo di ottimizzazione (chi può dire che la “prossima generazione” sarà migliore?). La mia ipotesi è che questa metafora (linguaggio) influenza il nostro modo di concepire e ragionare circa un oggetto (pensiero). Anticipando qualche dato, mi avvalgo delle discipline linguistiche, nell’ambito delle quali si parla dell’evoluzione non solo del linguaggio, ma anche della lingua. Ad esempio l’idea che una lingua sia meno complessa sintatticamente, come nel caso della lingua dei Pirahã del Sudamerica, ha generato il giudizio di “primitivismo” nei confronti del popolo che la parla da parte soprattutto di alcuni filochomskyiani e altri1. In altre scienze sociali, alcune manifestazioni culturali, come l’arte, vengono intese come “primitive” o “moderne”, oppure si parla di evoluzione di generi letterari. La dimostrazione forse più eclatante di questo antropocentrismo riguarda il problema del genere Homo, in cui l’avvento dell’Uomo Anatomicamente Moderno si fa coincidere con la nascita della cultura, utilizzando un doppio standard di modernità, visto che Neandertal fu probabilmente molto più simile a noi di quanto si tende a pensare2. L’utilizzo dell’idea di evoluzione come metafora può essere estremamente potente nell’ambiente accademico, ma occorre prestare attenzione alle sue possibili implicazioni. Il mio intento è quello di analizzare questa metafora usata comunemente all’interno delle varie discipline dal punto di vista della linguistica cognitiva (frames e metafore concettuali), mettendo in evidenza come il concetto target eredita delle implicazioni che emergono a causa delle qualità proprie del concetto source, per dimostrare che il modo in cui avviene il framing del concetto condiziona sovente la metodologia di studio, nonché la tassonomia applicata all’oggetto studiato.

Published
2008

16. How Body and Soul Interact with the Spiritual Mind

Author

Evola, Vito

Subjects
Psychology: Psycholinguistics, Psychology: Behavioral Analysis, Psychology: Applied Cognitive Psychology, Philosophy: Philosophy of Mind, Philosophy: Ethics, Linguistics: Semantics, Psychology: Social Psychology, Psychology: Cognitive Psychology, Psychology: Perceptual Cognitive Psychology, Philosophy: Philosophy of Language, Psycholinguistics, Behavioral Analysis, Applied Cognitive Psychology, Philosophy of Mind, Ethics, Semantics, Social Psychology, Cognitive Psychology, Perceptual Cognitive Psychology, Philosophy of Language
Abstract

Cognitive Linguistics as an enterprise provides new theoretical and methodological instruments in understanding the relationship between people’s thoughts and the language they use. Spiritual and religious experiences (particularly the ones involving some type of revelation from or communication with a transcendent being) are especially interesting since they involve some type of external, physically invisible force or agent, contributing an “ineffable” quality to the phenomenon. However, people can and do describe such events, and metaphors and blends pervade the representations of certain concepts of the transcendental when attempting to talk about such abstract ideas. One of the main tenants of Cognitive Linguistics is that people’s views about themselves and the world around them are deeply rooted in their conceptual systems, created by their experiences and their bodily interactions with the world, whether they be physical, psychological or social. People who practice spirituality reach certain states by means of personal or collective rituals, such as prayer, meditation, and bodily procedures involving discipline, as is the case of fasting or re-understanding pain. When they then communicate certain religious and spiritual concepts, they are revealing a great deal about themselves and their world and the way they interact with it. Concepts dealing with people’s system of beliefs are very “meaningful” for the individual, and the more entrenched a frame of mind is, the less plastic it is, a fact confirmed by the neurosciences which claim that it is difficult to break down and reconstruct certain synaptic structures of the brain. But how do people who have had such awesome experiences represent these supernatural encounters and their states of being? What is the relationship between the concepts of body and soul in devotees who torture their bodies, who have out of body experiences or who describe a body possessed by other spirits? What does the language they use say about the individuals’ concept of themselves and their world? I will present some of my own research data containing conceptual metaphors and blends collected in various sacred texts and during a series of interviews of people who claim to have had such supernatural experiences. The data includes linguistic expressions as well as gesture. Moreover, the interviewees were asked to draw on paper certain experiences of spiritual nature and then to describe their pictures. My investigation will try to shed new light on the phenomenology of spiritual experiences and personhood, using cognitive linguistics as a prime tool of analysis.

Published
2008

17. La metafora come carrefour cognitivo del pensiero e del linguaggio

Author

Evola, Vito and Casadio, Claudia

Subjects
Linguistics: Comparative Linguistics, Philosophy: Logic, Psychology: Psycholinguistics, Linguistics: Pragmatics, Psychology: Applied Cognitive Psychology, Philosophy: Philosophy of Mind, Philosophy: Philosophy of Science, Linguistics: Semantics, Psychology: Social Psychology, Psychology: Cognitive Psychology, Philosophy: Philosophy of Language, Linguistics: Learnability, Comparative Linguistics, Logic, Psycholinguistics, Pragmatics, Applied Cognitive Psychology, Philosophy of Mind, Philosophy of Science, Semantics, Social Psychology, Cognitive Psychology, Philosophy of Language, Learnability
Abstract

Nell’ultimo trentennio, le scienze cognitive hanno proposto una teoria alternativa a quelle che intendevano la metafora come strumento linguistico, cioè che il processo metaforico si potesse ridurre al livello letterale, semantico o pragmatico. Secondo la teoria della metafora concettuale, la metafora è un modo di rappresentare ed organizzare il nostro mondo, piuttosto che uno strumento semplicemente decorativo del linguaggio avente un ruolo puramente comunicativo. Questo shift paradigmatico ha influenzato anche altri aspetti delle scienze cognitive. In questo contributo si vuole delineare lo stato attuale della teoria esposta da Lakoff e Johnson e la maturazione del pensiero rispetto alla prima pubblicazione di Metaphors We Live By (1980/1998). Dopo avere illustrato i principi teorici, si daranno degli esempi di metafore culturali e multimodali e si puntualizzerà il ruolo analogo, ma distinto, alla metafora che la metonimia copre nell’ambito dei nostri sistemi concettuali.

Published
2008

18. Multimodal Semiotics of Representing God and the Self: a Cognitive Linguistic View of Metaphors and Gestures in Religious Discourse

Author

Evola, Vito

Subjects
Philosophy: Metaphysics, Psychology: Psycholinguistics, Psychology: Behavioral Analysis, Psychology: Applied Cognitive Psychology, Philosophy: Philosophy of Mind, Linguistics: Semantics, Psychology: Cognitive Psychology, Psychology: Perceptual Cognitive Psychology, Philosophy: Philosophy of Language, Metaphysics, Psycholinguistics, Behavioral Analysis, Applied Cognitive Psychology, Philosophy of Mind, Semantics, Cognitive Psychology, Perceptual Cognitive Psychology, Philosophy of Language
Abstract

I will explore some of my conclusions concerning conceptual metaphors collected during a series of interviews, in particular with two Christian street preachers. The data includes speech, gesture, and commented drawings of God, themselves and paradise. Some of the metaphors analyzed are: metaphors for God (FATHER, SHEPHERD, LOVER, etc); GOOD/GOD IS UP; BAD IS DOWN; STRICT FATHER vs. NURTURING PARENT; MORAL ACCOUNTABILITY. This data demonstrates that the more entrenched a frame of mind is, the less plastic it is, because the primary source domain of our habitual conceptual metaphor will always motivate any other “laminated domain mappings”, or blends, especially for such meaningful concepts like personhood or belief systems. My investigation will try to shed new light on the phenomenology of religious experiences and personhood, using cognitive linguistics as a prime tool of analysis.

Published
2008

19. Multimodal Semiotics of Spiritual Experiences: Representing Beliefs, Metaphors, and Actions

Author

Evola, Vito

Subjects
Psychology: Behavioral Analysis, Philosophy: Logic, Philosophy: Metaphysics, Psychology: Psycholinguistics, Psychology: Applied Cognitive Psychology, Philosophy: Ethics, Philosophy: Philosophy of Mind, Linguistics: Semantics, Psychology: Social Psychology, Psychology: Perceptual Cognitive Psychology, Psychology: Cognitive Psychology, Philosophy: Philosophy of Language, Behavioral Analysis, Logic, Metaphysics, Psycholinguistics, Applied Cognitive Psychology, Ethics, Philosophy of Mind, Semantics, Social Psychology, Perceptual Cognitive Psychology, Cognitive Psychology, Philosophy of Language
Abstract

Traditionally, spiritual experiences have been considered "ineffable," but metaphors pervade the representations of certain concepts of the transcendental in an attempt to talk about such abstract ideas. Whether it be during the description of a vision or simply talking about morality, people use conceptual metaphors to reason and talk about these concepts. Many representations of God, spirits, or the afterlife are culturally based, but whereas some may differ based on individual experiences, others seem to have a more universal character. From a phenomenological point of view, it seems that the descriptions are contingent and not necessary, that is, the language a believer is exposed to may influence, but not condition a priori, his or her own spiritual experience as Constructivists have thought. People's views about themselves and the world around them are deeply rooted in their conceptual systems, which are created by their experiences and their bodily interactions with the world, whether it's having to do with gravity in the case of UP and DOWN, or what our individual and social concepts are. When people talk about religious and spiritual concepts, they are revealing a great deal about their world and themselves and the way they interact with it. Concepts dealing with people's system of beliefs are very "meaningful" for the individual, and the more entrenched a frame of mind is, the less plastic it is, a fact confirmed by the neurosciences, which claim that it is difficult to break down and reconstruct certain synaptic structures of the brain. How do today's common "faithful" relate to certain metaphors about spiritual concepts transmitted by their faiths? What do these metaphors say about the individuals' concepts of themselves and their world? I will explore some of my own conclusions concerning conceptual metaphors and figurative language collected in various sacred texts and during a series of interviews of religious people with different backgrounds of religious systems. The data include linguistic expressions as well as gesture. Moreover, the interviewees were asked to draw on paper certain experiences of religious nature and then to describe their pictures. My investigation will try to shed new light on the phenomenology of religious experiences and personhood, using cognitive linguistics as a prime tool of analysis.

Published
2008

20. Cognitive Linguistics and the Evolution of Body and Soul in the Western World: from Ancient Hebrew to Modern English

Author

Evola, Vito

Subjects
Philosophy: Epistemology, Linguistics: Comparative Linguistics, Philosophy: Metaphysics, Psychology: Psycholinguistics, Linguistics: Pragmatics, Psychology: Evolutionary Psychology, Philosophy: Philosophy of Mind, Philosophy: Ethics, Linguistics: Semantics, Linguistics: Syntax, Psychology: Social Psychology, Psychology: Cognitive Psychology, Philosophy: Philosophy of Language, Linguistics: Historical Linguistics, Epistemology, Comparative Linguistics, Metaphysics, Psycholinguistics, Pragmatics, Evolutionary Psychology, Philosophy of Mind, Ethics, Semantics, Syntax, Social Psychology, Cognitive Psychology, Philosophy of Language, Historical Linguistics
Abstract

A philological and comparative analysis of the lexical items concerning personhood in Ancient Hebrew, Ancient Greek and Modern English reveals semantic shifts concerning the relative lexical concepts. Ancient Hebrew presents an essentially holistic idea of personhood, whereas, via Biblical translations and Greek philosophical influences, the Western World has conceptualized humans as being dualistic in nature. I analyze the polysemy and semantic shifts in the lexicon used for "body" and "soul" in Ancient Hebrew and Ancient Greek, which are the two linguistic systems known by St. Paul of Tarsus, and then confront them with Paul's usage context, and finally with Modern English, hypothesizing a possible case of linguistic relativity.

Published
2007

21. St. Paul's Error: The Semantic Changes of BODY and SOUL in the Western World

Author

Evola, Vito

Subjects
Linguistics: Comparative Linguistics, Philosophy: Metaphysics, Psychology: Psycholinguistics, Psychology: Evolutionary Psychology, Linguistics: Pragmatics, Philosophy: Philosophy of Mind, Philosophy: Ethics, Linguistics: Semantics, Linguistics: Syntax, Philosophy: Philosophy of Science, Psychology: Social Psychology, Philosophy: Philosophy of Language, Linguistics: Historical Linguistics, Comparative Linguistics, Metaphysics, Psycholinguistics, Evolutionary Psychology, Pragmatics, Philosophy of Mind, Ethics, Semantics, Syntax, Philosophy of Science, Social Psychology, Philosophy of Language, Historical Linguistics
Abstract

Historically Christianity owes much to Judaism. St. Paul’s Christianity, however, changed the way of thinking of many of the first Jews because of a new way of reasoning about selfhood, the human body, and human cognition. Without wanting to treat certain theological concepts, I want to underline how modern science’s view of the person is closer to traditional Judaism than it is to Christianity, and how Paul’s “error” was diffused throughout the Western world, by analyzing the semantics of linguistic references to the body, the soul, and emotions. What was St. Paul’s error? The question means to be both allusive and provocative. He was born by the name Saul in the city of Tarsus, in modern Turkey, during the height of its splendour as a Roman-Greek city. Paul grew up as a “free man”, that is, as a Roman citizen in a cosmopolitan environment. He is considered to be the most influential and productive of the testimonies of the Christian thought throughout Asia Minor and Western Europe. His epistles circulated throughout his time and continue to influence millions of followers, who often interpret his thoughts in contrasting manner, but nonetheless attest to his authority. An erudite Greek-Roman, persecutor of the first Christians, Paul battled to spread the story of Jesus of Nazareth. His ideology, indeed, is a blend of Greek-Roman thought and of what he learned from the first Christians. The Hellenic characteristics of his faith created a divergence from traditional Judaic thought within what was to become the Christian creed though his influence. As a matter of fact, Christianity came to have a more coherent structure because of Paul, and Christian belief in a way is more Paul’s thought than it is Jesus’. Jewish teaching circa selfhood was quite holistic. The Hebrew word nephesh is often translated as “soul” but also means “body”, whereas Paul clearly distinguishes the two, talking about a co-existence, “concupiscence” and the necessity of dominating the body to exalt the spirit. I will examine the semantic changes in words dealing with body and soul, and how Paul’s authority eventually influenced the Western world’s way of reasoning about such concepts.

Published
2006

22. Polisemia e slittamenti semantici nei concetti ANIMA e CORPO nel mondo occidentale, ovvero l'errore di San Paolo

Author

Evola, Vito

Subjects
Linguistics: Semantics, Linguistics: Morphology, Psychology: Psycholinguistics, Philosophy: Philosophy of Mind, Linguistics: Comparative Linguistics, Psychology: Social Psychology: Social simulation, Psychology: Social Psychology, Linguistics: Historical Linguistics, Psychology: Applied Cognitive Psychology, Philosophy: Philosophy of Language, Psychology: Cognitive Psychology, Linguistics: Pragmatics, Linguistics: Syntax, Philosophy: Epistemology, Philosophy: Metaphysics, Semantics, Morphology, Psycholinguistics, Philosophy of Mind, Comparative Linguistics, Social simulation, Social Psychology, Historical Linguistics, Applied Cognitive Psychology, Philosophy of Language, Cognitive Psychology, Pragmatics, Syntax, Epistemology, Metaphysics
Abstract

Storicamente il cristianesimo deve molto al giudaismo. Il cristianesimo di San Paolo, tuttavia, ha cambiato il modo di ragionare su concetti come il sé, il corpo, e la cognizione umana. Senza volere trattare certi concetti teologici, mi prefiggo di sottolineare come il punto di vista della scienza moderna è più vicino al giudaismo tradizionale che al cristianesimo, e di spiegare la diffusione dell’“errore” di Paolo nel mondo occidentale, analizzando la semantica dei riferimenti linguistici (e in particolar modo le metafore e le metonimie) dei concetti anima e corpo e del rapporto con la concezione del sé. Cresciuto da “uomo franco” cioè, da cittadino romano in un ambiente cosmopolita, Paolo è considerato il testimone più influente e produttivo del pensiero cristiano nell’Asia Minore e nell’Europa Occidentale. Le sue epistole circolarono durante la sua vita e continuano ad influenzare miliardi di seguaci, i quali spesso interpretano le sue idee in modo contrastante, ma ciononostante attestando una specifica autorevolezza. Erudito greco-romano, inizialmente persecutore dei primi Cristiani, Paolo ha lottato per diffondere la storia di Gesù di Nazareth. La sua ideologia, infatti, è stata vista da molti come un amalgama tra il pensiero greco-romano e ciò che egli stesso ha appreso dai primi cristiani. Queste caratteristiche elleniche, più o meno reali, del sistema religioso introdussero una differenza significativa all’interno del pensiero giudaico tradizionale, dal quale, per mezzo dell’influenza dei suoi scritti, si sarebbe sviluppato il credo cristiano. Di fatti, il cristianesimo ha acquisito una struttura più coerente grazie a Paolo, quasi da inferire che la fede cristiana deve più a Paolo che a Gesù. Quale era l’errore di San Paolo? La domanda vuole essere sia allusiva che provocatoria. L’insegnamento giudaico a proposito del concetto del sé era piuttosto olistico. Per esempio, la parola ebraica nephesh è spesso tradotta come “anima” ma, metaforicamente, significa anche “corpo”, mentre, secondo i suoi interpreti, Paolo chiaramente fa delle distinzioni dualistiche, e parlando della “concupiscenza” predica la necessità di dominare la carne per esaltare lo spirito. Con gli strumenti della linguistica cognitiva, propongo un’analisi della polisemia e degli slittamenti semantici nei concetti di ANIMA e CORPO, e come l’autorità attribuita a Paolo eventualmente ha influenzato il pensiero occidentale sul ragionare di queste rappresentazioni mentali.

Published
2006

23. Blending the Erotic and the Divine in Mystical Literature

Author

Evola, Vito

Subjects
Neuroscience: Neuropsychology, Linguistics: Semantics, Biology: Sociobiology, Psychology: Psycholinguistics, Philosophy: Philosophy of Mind, Linguistics: Comparative Linguistics, Psychology: Social Psychology, Linguistics: Historical Linguistics, Neuropsychology, Semantics, Sociobiology, Psycholinguistics, Philosophy of Mind, Comparative Linguistics, Social Psychology, Historical Linguistics
Abstract

THE BEGINNINGS OF SYMBOLIC-RELIGIOUS COGNITION - Cognitive Archeology and Cognitive Fluidity: About 30,000 years ago (70,000 years after the fossil records of the anatomically modern human), religious thought and symbolic conceptual activity arose from the capacity of integrating specific-domain a process called "cognitive fluidity" (Mithen 1996). Metaphor, Anthropomorphism and Cognitive Science: Metaphor is a basic mental capacity by which people understand themselves and the world around them through conceptual mappings of knowledge between mental spaces, using everyday knowledge to reason about more abstract concepts. Of all the templates for supernatural concepts, the ones that seriously matter to people are invariably person-like, because people are the most complex type of object that people know (Boyer 2001). WHY GOD AS AN EROTIC LOVER? - Diffusion and elaboration of religious memes: To reason about the ties between divine and human, man looks at his repertoire of human relationships, and the more significant ones are used to explain and speak of re-ligio. There are many metaphors used to represent the relationship between the divinity and the devotee (father/child, doctor/patient, teacher/pupil, etc.) The most significant relationship chosen by the mystic in terms of balance is Lover-Beloved. Blending between God and Lover: The idealized conceptual models of the Divinity/beloved and of a devotee/lover began to blend through composition, completion and elaboration. The concept of human love relationship of these ancient cultures probably needs to be re-evaluated by modern students if it had become such an entrenched concept to be used as a source for a cognitive input space. BLENDING THE EROTIC AND THE RELIGIOUS - Examples of erotic religious texts and emergent structure: Sir hassirim, or Song of Songs (Judeo-Christian); Jayadeva’s Gita Govinda (Hindu); Rumi’s Mathanawi (Islam). Strongly erotic in content, these are part of the canons of the respective religious traditions, and so have deeply influenced subsequent elaboration of the erotic symbolism The lover (the faithful) and the Beloved (the Divinity) are usually on a par, and the domination of one is hardly ever present. Poetic descriptions include psychological states of jealousy, passion, separation and reunion, and ultimate union. The time of reunion is spring and the place is nature. What emerges is a relationship that not only unilaterally satisfies the material and spiritual needs of the religious person, but is reciprocal. In other words, the needs of both parties are fulfilled (devotee: food, explanations; god: praise, sacrifice). Moreover, due to the blend, an emotional need is also fulfilled. The dignity of the woman is finding her place in society, like the devotee finds his/her place in his/her creator’s creation, and so their relationship must be lived in the same natural setting. Because of the fusion between counterpart input spaces, there is a completion that humanizes the divinity so it becomes a he, the Man, motivated by the dominating role. However the elaboration of the blend tends to eliminate any domination in the relationship, as the needs of both sides are equal, and only when they are united do they feel completely realized. Their place is in nature, at it’s most energetic and vibrant moment of springtime (ideally the time of life), and the time is eternal.

Published
2004

24. A Hermeneutic Model of Sacred Literature and Everyday Revelation

Author

Evola, Vito

Subjects
Linguistics: Comparative Linguistics, Comparative Linguistics
Abstract

Why do some people have life-changing experiences when reading sacred texts, and what makes them so differently significant readings as opposed to reading the newspaper or any kind of book? Exploring a set of metaphors used in the literature of mysticism, and in particular in the canonical literature of world religions, I use the instruments provided by conceptual integration and empirical data of the neurosciences to offer a hermeneutic model of the higher level understanding construed during on-line reading by devotees of their respective sacred literature. Constructivists of the past two decades have considered the mystical experience as a form of "reconditioning of consciousness," (the concepts condition a priori the experience), arguing that there are no pure (i.e. unmediated) experiences. I believe cognitive science helps prove that the description of the experience is contingent and not necessary; the language used in devotional literature to describe mystical experience influences the way of living the experience, but it is also motivated by its representing reality. Ultimately I will look at the model of erotic relationship in mystical literature and how it serves as evidence of non-reductive physicalism, seeing the human being as a multilevel psychosomatic unity.

Published
2003

25. Cognitive Semiotics and On-Line Reading of Religious Texts

Author

Evola, Vito, Hogan, Patrick Colm, and Meyer-Dinkgräfe, Daniel

Subjects
Linguistics: Semantics, Semantics
Abstract

In this essay a hermeneutic model of the higher level understanding during on-line ritual reading by devotees of their respective sacred literatures is proposed, using the instruments provided by cognitive sciences. The way a devotee reads a sacred text differs from the way he or she would read a common piece of literature or how a lay person might read the same sacred text. After providing an overview of metaphor, anthropomorphism, and the “religious brain”, it is suggested how devotee-readers might make sense of a religious text and why it should be so important for their own personal everyday life. Universals are implicated in this genre of literature and the way it is interpreted.

Published
2005

26. Poster session 4: Friday 5 December 2014, 08:30-12:30 * Location: Poster area

Author

Orii, M, Tanimoto, T, Yokoyama, M, Ota, S, Kubo, T, Hirata, K, Tanaka, A, Imanishi, T, Akasaka, T, Michelsen, MM, Pena, A, Mygind, ND, Hoest, NB, Prescott, E, Abd El Dayem, SOHA, Battah, AHMED, Abd El Azzez, FATEN, Ahmed, AZZA, Fattoh, AYA, Ismail, REEM, Andjelkovic, K, Kalimanovska Ostric, D, Nedeljkovic, I, Andjelkovic, I, Rashid, HESHAM, Abuel Enien, HESHAM, Ibraheem, MAHER, work, Tissue Doppler echocardiography research, Vago, H, Toth, A, Csecs, I, Czimbalmos, CS, Suhai, F I, Kecskes, K, Becker, D, Simor, T, Merkely, B, D'ascenzi, F, Pelliccia, A, Natali, BM, Cameli, M, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Zaha, VG, Kim, GE, Su, KN, Zhang, J, Mikush, N, Ross, J, Palmeri, M, Young, LH, Tadic, M, Ilic, SI, Celic, VC, Jaimes, C, Gonzalez Mirelis, J, Gallego, M, Goirigolzarri, J, Pellegrinet, M, Poli, S, Prati, G, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Mateescu, A, Popescu, BA, Antonini-Canterin, F, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Hewing, B, Theres, L, Dreger, H, Spethmann, S, Stangl, K, Baumann, G, Knebel, F, Uejima, T, Itatani, K, Nakatani, S, Lancellotti, P, Seo, Y, Zamorano, JL, Ohte, N, Takenaka, K, group, VFM international collaboration, Naar, J, Mortensen, L, Johnson, J, Winter, R, Shahgaldi, K, Manouras, A, Braunschweig, F, Stahlberg, M, Coisne, D, Al Arnaout, A-M, Tchepkou, C, Raud Raynier, P, Diakov, C, Degand, B, Christiaens, L, Barbier, P, Mirea, O, Cefalu, C, Savioli, G, Guglielmo, M, Maltagliati, A, O'neill, L, Walsh, K, Hogan, J, Manzoor, T, Ahern, B, Owens, P, Savioli, G, Guglielmo, M, Mirea, O, Cefalu, C, Barbier, P, Sengelov, M, Biering-Sorensen, T, Jorgensen, PG, Bruun, NE, Fritz-Hansen, T, Bech, J, Olsen, FJ, Sivertsen, J, Jensen, JS, Marta, L, Abecasis, J, Reis, C, Ribeiras, R, Andrade, MJ, Mendes, M, D'andrea, A, Stanziola, A, Di Palma, E, Martino, M, Lanza, M, Betancourt, V, Maglione, M, Calabro', R, Russo, MG, Bossone, E, Vogt, M O, Meierhofer, CH, Rutz, TH, Fratz, S, Ewert, P, Roehlig, CH, Kuehn, A, Storsten, P, Eriksen, M, Remme, EW, Boe, E, Smiseth, OA, Skulstad, H, Ereminiene, E, Ordiene, R, Ivanauskas, V, Vaskelyte, J, Stoskute, N, Kazakauskaite, E, Benetis, R, Marketou, M, Parthenakis, F, Kontaraki, J, Zacharis, E, Maragkoudakis, S, Logakis, J, Roufas, K, Vougia, D, Vardas, P, Dado, E, Dado, E, Knuti, G, Djamandi, J, Shota, E, Sharka, I, Saka, J, Halmai, L, Nemes, A, Kardos, A, Neubauer, S, Kurnicka, K, Domienik-Karlowicz, J, Lichodziejewska, B, Goliszek, S, Grudzka, K, Krupa, M, Dzikowska-Diduch, O, Ciurzynski, M, Pruszczyk, P, Chung, H, Kim, JY, Yoon, YW, Min, PK, Lee, BK, Hong, BK, Rim, SJ, Kwon, HM, Choi, EY, Soya, OV, Kuryata, OV, Kakihara, R, Naruse, C, Inayoshi, A, El Sebaie, MAHA, Frer, ABDEL, Abdelsamie, MAGDY, Eldamanhory, AHMED, Ciampi, Q, Cortigiani, L, Simioniuc, A, Manicardi, C, Villari, B, Picano, E, Sicari, R, Ferferieva, V, Deluyker, D, Lambrichts, I, Rigo, JM, Bito, V, Kuznetsov, VA, Yaroslavskaya, EI, Krinochkin, DV, Pushkarev, GS, Gorbatenko, EA, Trzcinski, P, Michalski, BW, Lipiec, P, Szymczyk, E, Peczek, L, Nawrot, B, Chrzanowski, L, Kasprzak, JD, Todaro, MC, Zito, C, Khandheria, BK, Cusma-Piccione, M, La Carrubba, S, Antonini-Canterin, F, Di Bello, V, Oreto, G, Di Bella, G, Carerj, S, Gunyeli, E, Oliveira Da Silva, C, Sahlen, A, Manouras, A, Winter, R, Shahgaldi, K, Spampinato, RA, Tasca, M, Roche E Silva, JG, Strotdrees, E, Schloma, V, Dmitrieva, Y, Dobrovie, M, Borger, MA, Mohr, FW, Einarsen, E, Cramariuc, D, Lonnebakken, MT, Boman, K, Gohlke-Barwolf, C, Chambers, JB, Gerdts, E, Calin, A, Rosca, M, Beladan, CC, Mirescu Craciun, A, Gurzun, MM, Mateescu, A, Enache, R, Ginghina, C, Popescu, BA, Antova, E, Georgievska Ismail, LJ, Srbinovska, E, Andova, V, Peovska, I, Davceva, J, Otljanska, M, Vavulkis, M, Tsuruta, H, Kohsaka, S, Murata, M, Yasuda, R, Dan, M, Yashima, F, Inohara, T, Maekawa, Y, Hayashida, K, Fukuda, K, Migliore, R, Adaniya, ME, Barranco, MA, Miramont, G, Gonzalez, S, Tamagusuku, H, Abid, L, Ben Kahla, S, Charfeddine, S, Abid, D, Kammoun, S, Amano, M, Izumi, C, Miyake, M, Tamura, T, Kondo, H, Kaitani, K, Nakagawa, Y, Ghulam Ali, S, Fusini, L, Tamborini, G, Muratori, M, Gripari, P, Bottari, V, Celeste, F, Cefalu', C, Alamanni, F, Pepi, M, Obase, K, Mor-Avi, V, Weinert, L, Lang, R, Teixeira, R, Monteiro, R, Garcia, J, Ribeiro, M, Cardim, N, Goncalves, L, Miglioranza, MH, Muraru, D, Cavalli, G, Addetia, K, Cucchini, U, Mihaila, S, Tadic, M, Veronesi, F, Lang, RM, Badano, L, Galian Gay, L, Gonzalez Alujas, MT, Teixido Tura, G, Gutierrez Garcia, L, Rodriguez-Palomares, JF, Evangelista Masip, A, Conte, L, Fabiani, I, Giannini, C, La Carruba, S, De Carlo, M, Barletta, V, Petronio, AS, Di Bello, V, Mahmoud, H, Al-Ghamdi, M, Ghabashi, A, Salaun, E, Zenses, AS, Evin, M, Collart, F, Pibarot, P, Habib, G, Rieu, R, Fabregat Andres, O, Estornell Erill, J, Cubillos-Arango, A, Bochard-Villanueva, B, Chacon-Hernandez, N, Higueras-Ortega, L, Perez-Bosca, L, Paya-Serrano, R, Ridocci-Soriano, F, Cortijo-Gimeno, J, Mzoughi, K, Zairi, I, Jabeur, M, Ben Moussa, F, Mrabet, K, Kamoun, S, Fennira, S, Ben Chaabene, A, Kraiem, S, Schnell, F, Betancur, J, Daudin, M, Simon, A, Lentz, PA, Tavard, F, Hernandes, A, Carre, F, Garreau, M, Donal, E, Abduch, MCD, Vieira, MLC, Antunes, M, Mathias, W, Mady, C, Arteaga, E, Alencar, AM, Tesic, M, Djordjevic-Dikic, A, Beleslin, B, Giga, V, Trifunovic, D, Petrovic, O, Jovanovic, I, Petrovic, M, Stepanovic, J, Vujisic-Tesic, B, Choi, EY, Cha, JJ, Chung, H, Kim, KH, Yoon, YW, Kim, JY, Lee, BK, Hong, BK, Rim, SJ, Kwon, HM, Bergler-Klein, J, Geier, C, Maurer, G, Gyongyosi, M, Cortes Garcia, M, Oliva, MR, Navas, MA, Orejas, M, Rabago, R, Martinez, ME, Briongos, S, Romero, AM, Rey, M, Farre, J, Ruisanchez Villar, C, Ruiz Guerrero, L, Rubio Ruiz, S, Lerena Saenz, P, Gonzalez Vilchez, FJ, Hernandez Hernandez, JL, Armesto Alonso, S, Blanco Alonso, R, Martin Duran, R, Gonzalez-Gay, MA, Novo, G, Marturana, I, Bonomo, V, Arvigo, L, Evola, V, Karfakis, G, Lo Presti, M, Verga, S, Novo, S, Petroni, R, Acitelli, A, Bencivenga, S, Cicconetti, M, Di Mauro, M, Petroni, A, Romano, S, Penco, M, Park, SM, Kim, SA, Kim, MN, Shim, WJ, Tadic, M, Majstorovic, AM, Ivanovic, BI, Celic, VC, Driessen, M M P, Meijboom, FJ, Mertens, L, Dragulescu, A, Friedberg, MK, De Stefano, F, Santoro, C, Buonauro, A, Muscariello, R, Lo Iudice, F, Ierano, P, Esposito, R, Galderisi, M, Sunbul, M, Kivrak, T, Durmus, E, Yildizeli, B, Mutlu, B, Rodrigues, AC, Daminello, E, Echenique, LS, Cordovil, A, Oliveira, W, Monaco, CH, Lira, E, Fischer, CH, Vieira, M, Morhy, S, Mignot, A, Jaussaud, J, Chevalier, L, Lafitte, S, D'ascenzi, F, Cameli, M, Curci, V, Alvino, F, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Ikonomidis, I, Pavlidis, G, Lambadiari, V, Kousathana, F, Triantafyllidi, H, Varoudi, M, Dimitriadis, G, Lekakis, J, Cho, J S, Cho, EJ, Yoon, HJ, Ihm, SH, Lee, JH, Molnar, A A, Kovacs, A, Apor, A, Tarnoki, AD, Tarnoki, DL, Horvath, T, Maurovich-Horvat, P, Jermendy, GY, Kiss, RG, Merkely, B, Al-Habbaa, A, Petrovic-Nagorni, S, Ciric-Zdravkovic, S, Stanojevic, D, Jankovic-Tomasevic, R, Atanaskovic, V, Mitic, V, Todorovic, L, Dakic, S, Park, J S, Choi, JH, Kim, SH, Choi, JH, Kwon, YS, Jin, HY, Coppola, C, Piscopo, G, Galletta, F, Maurea, C, Esposito, E, Barbieri, A, Maurea, N, Kaldararova, M, Tittel, P, Kantorova, A, Vrsanska, V, Kollarova, E, Hraska, V, Nosal, M, Ondriska, M, Masura, J, Simkova, I, Tadeu, I, Azevedo, O, Lourenco, M, Luis, F, Lourenco, A, Planinc, i, Bagadur, G, Bijnens, B, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Milicic, D, Cikes, M, Campanale, C M, Di Maria, S, Mega, S, Nusca, A, Marullo, F, Di Sciascio, G, El Tahlawi, M, Abdallah, M, Gouda, M, Gad, MARWA, Elawady, M, Igual Munoz, B, Maceira Gonzalez Alicia, AMG, Estornell Erill, JEE, Donate Betolin, LDB, Vazquez Sanchez Alejandro, AVS, Valera Martinez, FVM, Sepulveda- Sanchez, PSS, Cervera Zamora, ACZ, Piquer Gil Marina, MPG, Montero- Argudo, AMA, Naka, KK, Evangelou, D, Lakkas, L, Kalaitzidis, R, Bechlioulis, A, Gkirdis, I, Tzeltzes, G, Nakas, G, Pappas, K, Michalis, LK, Mansencal, N, Bagate, F, Arslan, M, Siam-Tsieu, V, Deblaise, J, El Mahmoud, R, Dubourg, O, Wierzbowska-Drabik, K, Plewka, M, Kasprzak, JD, Bandera, F, Generati, G, Pellegrino, M, Alfonzetti, E, Labate, V, Villani, S, Gaeta, M, Guazzi, M, Bandera, F, Generati, G, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Generati, G, Bandera, F, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Grycewicz, T, Szymanska, K, Grabowicz, W, Lubinski, A, Sotaquira, M, Pepi, M, Tamborini, G, Caiani, EG, Bochard Villanueva, B, Chacon-Hernandez, N, Fabregat-Andres, O, Garcia-Gonzalez, P, Cubillos-Arango, A, De La Espriella-Juan, R, Albiach-Montanana, C, Berenguer-Jofresa, A, Perez-Bosca, JL, Paya-Serrano, R, Cheng, H-L, Huang, C-H, Wang, Y-C, Chou, W-H, Kuznetsov, VA, Melnikov, NN, Krinochkin, DV, Kolunin, GV, Enina, TN, Sierraalta, W, Le Bihan, D, Barretto, RBM, Assef, JE, Gospos, M, Buffon, M, Ramos, AIO, Garcia, A, Pinto, IMF, Souza, AGMR, Mueller, H, Reverdin, S, Ehret, G, Conti, L, Dos Santos, S, Abdel Moneim, S S, Nhola, L F, Huang, R, Kohli, M, Longenbach, S, Green, M, Villarraga, H R, Bordun, K A, Jassal, D S, Mulvagh, S L, Evangelista, A, Madeo, A, Piras, P, Giordano, F, Giura, G, Teresi, L, Gabriele, S, Re, F, Puddu, P, Torromeo, C, Suwannaphong, S, Vathesatogkit, P, See, O, Yamwong, S, Katekao, W, Sritara, P, Iliuta, L, Szulik, M, Streb, W, Wozniak, A, Lenarczyk, R, Sliwinska, A, Kalarus, Z, Kukulski, T, Weng, K-P, Lin, C-C, Hein, S, Lehmann, L, Kossack, M, Juergensen, L, Katus, HA, Hassel, D, Turrini, F, Scarlini, S, Giovanardi, P, Messora, R, Mannucci, C, Bondi, M, Olander, R, Sundholm, JKM, Ojala, TH, Andersson, S, Sarkola, T, Karolyi, M, Kocsmar, I, Raaijmakers, R, Kitslaar, PH, Horvath, T, Szilveszter, B, Merkely, B, Maurovich-Horvat, P, Heart, Center, Vascular, University, Semmelweis, Budapest, Hungary, and Group, MTA-SE Lendület Cardiovascular Imaging Research

Abstract

Purpose: Although delayed-enhancement magnetic resonance imaging (DEMRI) is essential for diagnosis of cardiac sarcoidosis (CS), the test was not available when pacemaker was implamted. Recently, MR-conditional pacemaker has become avilable and we hypothesized that this device would be useful for diagnosis and management of CS. The aim of this study was to assess the diagnostic ability of MR-conditional pacemaker about CS in patients with advanced A-V nodal block (AAVB). Methods: Twenty-seven AAVB patients (14 men, 13 women; mean age, 69 ± 11 years) who were implanted MR-conditional pacemaker were studied. DEMRI was performed 6 weeks after implantation of permanent pacemaker. In patients with positive for DE, additional examinations like echocardiography, radioisotope imaging, biopsy, and coronary computed-tomography were performed due to confirm the diagnosis of CS and exclude coronary artery disease. Results: DE was observed in 12 patients (44 %). Out of 12 patients, 2 patients were excluded for having prior myocardial infarction. Seven of 10 (70 %) patients were diagnosed of CS by the consensus criteria. Compared with non-CS group, CS group had significantly lower age (61 ± 12 years vs. 72 ± 9 years p = 0.017). There was no significant difference about sex, angiotensin-converting enzyme, brain natriuretic peptide, and left ventricular ejection fraction between 2 groups. Six patients had started corticosteroid therapy and 5 patients (83%) recovered A-V nodal conduction. Conclusion: MR-conditional pacemaker was useful for diagnosis and management of patients with AAVB caused by CS. Figure Cardiac MRI in patient with AV block

Published
2014
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27. Echocardiographic assessment of coronary microvascular dysfunction: Basic concepts, technical aspects, and clinical settings

Author

Matteo Cameli, Vincenzo Evola, Flavio D'Ascenzi, Antonello D'Andrea, Alessandro Malagoli, Ercole Tagliamonte, Giulia Elena Mandoli, Francesco Bandera, Andreina Carbone, Eduardo Bossone, Doralisa Morrone, Ciro Santoro, Simona Sperlongano, Carbone, A., D'Andrea, A., Sperlongano, S., Tagliamonte, E., Mandoli, G. E., Santoro, C., Evola, V., Bandera, F., Morrone, D., Malagoli, A., D'Ascenzi, F., Bossone, E., Cameli, M., Carbone, Andreina, D'Andrea, Antonello, Sperlongano, Simona, Tagliamonte, Ercole, Mandoli, Giulia Elena, Santoro, Ciro, Evola, Vincenzo, Bandera, Francesco, Morrone, Doralisa, Malagoli, Alessandro, D'Ascenzi, Flavio, Bossone, Eduardo, and Cameli, Matteo

Subjects
medicine.medical_specialty, Myocardial ischemia, coronary flow reserve, coronary physiology, Myocardial Ischemia, Reviews, Clinical settings, Review, 030204 cardiovascular system & hematology, Doppler echocardiography, coronary microvascular dysfunction, microcirculation, Blood Flow Velocity, Coronary Circulation, Echocardiography, Echocardiography, Doppler, Humans, Microcirculation, Coronary Vessels, 03 medical and health sciences, Coronary circulation, 0302 clinical medicine, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Coronary Vessel, medicine.diagnostic_test, business.industry, Doppler, Coronary flow reserve, Blood flow, medicine.anatomical_structure, Cardiology, Cardiology and Cardiovascular Medicine, business, Coronary physiology, Human
Abstract

Coronary flow reserve is the capacity of the coronary circulation to augment the blood flow in response an increase in myocardial metabolic demands and has a powerful prognostic significance in different clinical situations. It might assess with invasive and noninvasive technique. Transthoracic echocardiography Doppler is an emerging diagnostic technique, noninvasive, highly feasible, safe for patient and physician, without radiation, and able to detect macrovascular and microvascular anomalies in the coronary circulation. This review aims to describe the benefit and limits of echocardiographic assessment of coronary flow reserve.

Published
2021
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28. Cor pulmonale: the role of traditional and advanced echocardiography in the acute and chronic settings

Author

Nicolò Sisti, Alessandro Malagoli, Regina Sorrentino, Sergio Mondillo, Antonello D'Andrea, Ciro Santoro, Elena Bargagli, Giulia Elena Mandoli, Paolo Cameli, Dan Nistor, Maurizio Galderisi, Vincenzo Evola, Carlotta Sciaccaluga, Matteo Cameli, Roberta Esposito, Francesco Bandera, Mandoli, G. E., Sciaccaluga, C., Bandera, F., Cameli, P., Esposito, R., D'Andrea, A., Evola, V., Sorrentino, R., Malagoli, A., Sisti, N., Nistor, D., Santoro, C., Bargagli, E., Mondillo, S., Galderisi, M., and Cameli, M.

Subjects
medicine.medical_specialty, Hypertension, Pulmonary, Disease, 030204 cardiovascular system & hematology, Acute cor pulmonale, Article, Pulmonary hypertension, 03 medical and health sciences, Cor pulmonale, 0302 clinical medicine, Pulmonary Heart Disease, Internal medicine, medicine, Humans, In patient, Right ventricular dysfunction, Pathological, Heart Failure, Ventricular function, business.industry, medicine.disease, medicine.anatomical_structure, 030228 respiratory system, Echocardiography, Ventricle, Right heart failure, Heart failure, Ventricular Function, Right, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

Cor pulmonale is the condition in which the right ventricle undergoes morphological and/or functional changes due to diseases that affect the lungs, the pulmonary circulation, or the breathing process. Depending on the speed of onset of the pathological condition and subsequent effects on the right ventricle, it is possible to distinguish the acute cor pulmonale from the chronic type of disease. Echocardiography plays a central role in the diagnostic and therapeutic work-up of these patients, because of its non-invasive nature and wide accessibility, providing its greatest usefulness in the acute setting. It also represents a valuable tool for tracking right ventricular function in patients with cor pulmonale, assessing its stability, deterioration, or improvement during follow-up. In fact, not only it provides parameters with prognostic value, but also it can be used to assess the efficacy of treatment. This review attempts to provide the current standards of an echocardiographic evaluation in both acute and chronic cor pulmonale, focusing also on the findings present in the most common pathologies causing this condition.

Published
2020
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29. Usefulness of Stress Echocardiography in the Management of Patients Treated with Anticancer Drugs

Author

Maurizio Galderisi, Antonello D'Andrea, Maria Concetta Pastore, Daniela Di Lisi, Ciro Santoro, Roberta Esposito, Simona Sperlongano, Giulia Elena Mandoli, Matteo Cameli, Vincenzo Evola, Giuseppina Novo, Girolamo Manno, Novo, Giuseppina, Santoro, Ciro, Manno, Girolamo, Di Lisi, Daniela, Esposito, Roberta, Mandoli, Giulia Elena, Evola, Vincenzo, Pastore, Maria Concetta, Sperlongano, Simona, D'Andrea, Antonello, Cameli, Matteo, Galderisi, Maurizio, Novo G., Santoro C., Manno G., Di Lisi D., Esposito R., Mandoli G.E., Evola V., Pastore M.C., Sperlongano S., D'Andrea A., Cameli M., and Galderisi M.

Subjects
medicine.medical_specialty, medicine.medical_treatment, Antineoplastic Agents, 030204 cardiovascular system & hematology, Coronary artery disease, 030218 nuclear medicine & medical imaging, Antineoplastic Agent, 03 medical and health sciences, 0302 clinical medicine, Antineoplastic therapeutic protocols, Echocardiography, Stre, Neoplasms, Antineoplastic therapeutic protocol, medicine, Stress Echocardiography, Humans, Radiology, Nuclear Medicine and imaging, In patient, CAD, Intensive care medicine, Antineoplastic therapeutic protocols, CAD, Cardio-oncology, Cardiotoxicity, Coronary artery disease, Stress echocardiography, Cardiotoxicity, Early Detection of Cancer, Echocardiography, Echocardiography, Stress, Humans, Antineoplastic Agents, Neoplasms, Early Detection of Cancer, Subclinical infection, Chemotherapy, Cardiotoxicity, business.industry, Cancer, Cardio-oncology, Stress echocardiography, medicine.disease, Anticancer treatment, Echocardiography, Cardiology and Cardiovascular Medicine, business, Human, Echocardiography, Stress
Abstract

In recent years, the survival of patients with cancer has improved thanks to advances in antineoplastic therapeutic protocols. This has led to an increasing burden of cardiovascular complications related to cancer treatment. Therefore, a new branch of cardiology has been created, ``cardio-oncology,'' with the aims of preventing cardiovascular complications related to antineoplastic treatment, achieving early diagnosis and treatment of any complications, and allowing completion of the expected antineoplastic treatment. Stress echocardiography has a pivotal role in achieving a timely diagnosis of coronary artery disease and thus is the best management approach in this clinical setting. Atherosclerotic processes can be exacerbated by both chemotherapy and chest irradiation in patients with cancer, even several years after anticancer treatment completion. Moreover, stress echocardiography has many other potential applications, such as in the evaluation of subclinical left ventricular dysfunction and contractile reserve in patients treated with anticancer drugs that have the potential to induce myocardial damage, as well as evaluating valve disease. The objective of this review is to delineate the role of stress echocardiography in cardio-oncology.

Published
2020

30. Identification of cardiac organ damage in arterial hypertension: insights by echocardiography for a comprehensive assessment

Author

Flavio D'Ascenzi, Sergio Mondillo, Giulia Elena Mandoli, Regina Sorrentino, Anna Vittoria Mattioli, Roberto Pedrinelli, Maurizio Galderisi, Antonello D'Andrea, Roberta Esposito, Maria Lembo, Marco Matteo Ciccone, Riccardo Liga, Pasquale Palmiero, Francesco Bandera, Pietro Scicchitano, Carlotta Sciaccaluga, Vincenzo Evola, Ciro Santoro, Annapaola Zito, Matteo Cameli, Cameli, M., Lembo, M., Sciaccaluga, C., Bandera, F., Ciccone, M. M., D'Andrea, A., D'Ascenzi, F., Esposito, Roberta, Evola, V., Liga, R., Mandoli, G. E., Palmiero, P., Santoro, C., Scicchitano, P., Sorrentino, R., Zito, A., Pedrinelli, R., Mondillo, S., Mattioli, A. V., and Galderisi, M.

Subjects
Aortic valve, medicine.medical_specialty, arterial hypertension, Physiology, Heart Ventricles, Diastole, Hemodynamics, Context (language use), Speckle tracking echocardiography, Regurgitation (circulation), 030204 cardiovascular system & hematology, cardiac organ damage, diastolic dysfunction, echocardiography, left ventricular hypertrophy, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Internal Medicine, Medicine, Humans, 030212 general & internal medicine, Risk factor, business.industry, medicine.disease, Prognosis, Stenosis, medicine.anatomical_structure, Echocardiography, Aortic Valve, Hypertension, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

Arterial hypertension, a widespread disease, whose prevalence increases with age, represents a major risk factor for cardiovascular events, causing damage in several organs, including the heart. In this context, echocardiography has a clear and pivotal role, being able to assess cardiac morphology and detect haemodynamic changes induced by this disease. 2018 European Society of Cardiology/European Society of Hypertension guidelines on AH identified main echo parameters such as left ventricular mass, relative wall thickness and left atrial volume, for detecting cardiac organ damage. The present review highlights the advantage of additional echocardiographic parameters such as diastolic measurement and both thoracic and abdominal aortic dimensions. An overlook on aortic valve should also be suggested to detect aortic regurgitation and stenosis, both frequent complications in hypertensive patients. In this kind of comprehensive assessment, the combination of standard and advanced echocardiography (speckle tracking echocardiography and, with a lesser extent, three-dimensional echocardiography) could be considered to improve the diagnostic accuracy, stratify prognosis and address management in arterial hypertension.

Published
2020

31. Speckle tracking evaluation in endurance athletes: the 'optimal' myocardial work

Author

Vincenzo Evola, Giulia Elena Mandoli, Antonello D'Andrea, Ciro Santoro, Flavio D'Ascenzi, Matteo Cameli, Andreina Carbone, Eduardo Bossone, Juri Radmilovic, Maurizio Galderisi, Francesco Bandera, D'Andrea, A., Radmilovic, J., Carbone, A., Mandoli, G. E., Santoro, C., Evola, V., Bandera, F., D'Ascenzi, F., Bossone, E., Galderisi, M., and Cameli, M.

Subjects
Male, Time Factors, Predictive Value of Test, 030204 cardiovascular system & hematology, Ventricular Function, Left, Heart Ventricle, Endurance athlete, 0302 clinical medicine, Eccentric, 030212 general & internal medicine, Prospective Studies, Myocardial work, Observer Variation, Ejection fraction, Two-dimensional strain, Exercise Tolerance, biology, Ventricular Remodeling, Tinea Pedi, Echocardiography, Doppler, medicine.anatomical_structure, Cardiology, Endurance athletes, Female, Cardiology and Cardiovascular Medicine, Case-Control Studie, Echocardiography, Stress, Human, Adult, medicine.medical_specialty, Time Factor, Heart Ventricles, Reproducibility of Result, 03 medical and health sciences, Athlete, Endurance training, Predictive Value of Tests, Internal medicine, Echocardiography, Stre, medicine, Stress Echocardiography, Humans, Radiology, Nuclear Medicine and imaging, Exertion, Athletes, business.industry, Reproducibility of Results, Tinea Pedis, Contractile reserve, Stroke Volume, biology.organism_classification, Myocardial Contraction, Stress echocardiography, Prospective Studie, Blood pressure, Ventricle, Case-Control Studies, Exercise Test, Physical Endurance, business
Abstract

To analyze left ventricular myocardial deformation and contractile reserve in endurance athletes at rest and during exercise, and their possible correlations with functional capacity. The athlete’s heart in endurance training is characterized by physiologic eccentric remodeling, with left ventricle adaptation at rest and echocardiographic parameters at low end of normality. Assessment of left ventricle systolic function and contractile reserve has an important role in the decision-making and in differential diagnosis with cardiomyopathies. Standard echo, lung ultrasound, left ventricle 2D speckle-tracking strain and myocardial work were performed at rest and during exercise in endurance athletes and in age- and sex-comparable healthy controls. 350 endurance athletes (male sex 58.5%; 31.6 ± 4.2 years) and 150 healthy controls were enrolled. Left ventricular ejection fraction at baseline was comparable between the two groups. Resting left ventricular global longitudinal strain was reduced in endurance athletes (− 18.4 ± 2.6% vs. − 22.4 ± 3.3% in controls; p

Published
2020

32. Basic and advanced echocardiography in advanced heart failure: an overview

Author

Giovanni Benfari, Serafina Valente, Francesco Bandera, Regina Sorrentino, Roberta Esposito, Giulia Elena Mandoli, Antonello D'Andrea, Matteo Cameli, Maurizio Galderisi, Hatem Soliman Aboumarie, Vincenzo Evola, Paolo Cameli, Ciro Santoro, Sergio Mondillo, Maria Concetta Pastore, Pastore, M. C., Mandoli, G. E., Aboumarie, H. S., Santoro, C., Bandera, F., D'Andrea, A., Benfari, G., Esposito, Roberta, Evola, V., Sorrentino, R., Cameli, P., Valente, S., Mondillo, S., Galderisi, M., and Cameli, M.

Subjects
medicine.medical_specialty, Functional indices, LVAD, medicine.medical_treatment, Advanced heart failure, Heart Ventricles, Population, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, 030212 general & internal medicine, Intensive care medicine, education, Speckle tracking, Heart transplantation, Heart Failure, education.field_of_study, 3D echocardiography, business.industry, Mortality rate, Gold standard, Stroke Volume, medicine.disease, Clinical Practice, Echocardiography, Heart failure, Cardiology and Cardiovascular Medicine, business, Medical therapy
Abstract

Advanced chronic heart failure (ACHF) is the last phase in the evolution of heart failure and is characterized by high hospitalization and mortality rates and is refractory to medical therapy, therefore requiring more aggressive therapies, such as mechanical circulatory support or heart transplantation. Over the last years, the incidence of ACHF was continuously growing, together with the increase in population survival rates. Therefore, the early recognition of the transition to ACHF is of crucial importance in HF patients, which also helps in prognostication of such patients, since advanced therapeutic options are limited to selected patients and they also have some important risk implications. Echocardiography is the gold standard tool for the evaluation of patients with HF; moreover, the recent technological advances provided new structural and functional indices of the four cardiac chambers that showed to be comparable to advanced imaging or invasive hemodynamic parameters. This allows us to operate an accurate study of ACHF with first- and second-level echocardiographic techniques, which are now being integrated in daily clinical practice. The present review presents an overview of the currently available tools for the echocardiographic examination of patients with ACHF, with its advantages and limitations, based on the latest supporting evidences.

Published
2019

33. Erectile dysfunction is associated with low total serum testosterone levels and impaired flow-mediated vasodilation in intermediate risk men according to the framingham risk score

Author

Giuseppina Novo, Vincenzo Evola, Salvatore Novo, Vito Bonomo, Egle Corrado, R Iacona, Carlo Pavone, Mariaconcetta Di Piazza, Novo, S, Iacona, R, Bonomo, V, Evola, V, Corrado, E, Di Piazza, M, Novo, G, and Pavone, C

Subjects
Adult, Male, medicine.medical_specialty, Brachial Artery, Flow mediated vasodilation, Risk Assessment, Severity of Illness Index, Asymptomatic, Settore MED/24 - Urologia, Peripheral Arterial Disease, Risk Factors, medicine.artery, Internal medicine, Diabetes mellitus, Odds Ratio, Humans, Medicine, Testosterone, Erectile dysfunction, Brachial artery, Aged, Aged, 80 and over, Serum testosterone levels, Chi-Square Distribution, Framingham Risk Score, business.industry, Endothelial function, Testosterone (patch), Odds ratio, Middle Aged, medicine.disease, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Vasodilation, Logistic Models, Endocrinology, Regional Blood Flow, Multivariate Analysis, Linear Models, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Body mass index, Biomarkers
Abstract

Background: The role erectile dysfunction (ED) coupled with low testosterone levels as early markers of atherosclerosis is not well understood. Objectives: To analyze the relationship between serum testosterone levels with both ED and brachial artery flow-mediated vasodilation (FMD), in a primary prevention sample of men. Methods: We enrolled 802 asymptomatic, intermediate CV risk patients, according to the Framingham Risk Score, aged 40e80 years, who underwent the ultrasound examination of FMD, the evaluation of ED and the assessment of total serum testosterone levels. Results: Testosterone levels correlated both with FMD (r ¼ 0.85; p < 0.0001) and IIEF-5 score (rs ¼ 0.65; p < 0.0001). Multivariable logistic regression analyses revealed that lower serum testosterone levels were strongly associated (p < 0.001) with severe (OR 0.78; 95% CI: 0.62e0.86), and moderate ED (OR 0.85; 95% CI: 0.72 e0.97), while impaired FMD percentages were strongly associated (p < 0.001) with severe (OR 0.68; 95% CI: 0.59e0.79), moderate (OR 0.76; 95% CI: 0.63e0.83) and mild to moderate ED (OR 0.8; 95% CI: 0.69 e0.94). Mild ED resulted statistically associated with lower FMD (OR 0.94; 95% CI: 0.82 e 1.07; p ¼ 0.03) but not with serum testosterone levels. These relations were not substantially affected by adjustments for further potential confounders including smoking status, hypertension, diabetes mellitus and body mass index. Conclusions: lower total serum testosterone levels are associated with impaired FMD and ED in this sample of intermediate CV risk men according to the Framingham Risk Score

Published
2015
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36. Testosterone levels are directly related with erectile function and endothelial function in men with intermediate risk according to the Framingham score

Author

NOVO, Salvatore, EVOLA, Vito, NOVO, Giuseppina, PAVONE, Carlo, Iacona, R, Bonomo, V, Di Piazza, M, Novo, S, Iacona, R, Bonomo, V, Di Piazza, M, Evola, V, Novo, G, and Pavone, C

Subjects
testosterone levels, endothelial function, erectile function, Framingham score, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Settore MED/24 - Urologia
Abstract

Background. The value of testosterone levels and erectile dysfunction (ED) as early markers of atherosclerosis is not well understood. Objectives. To analyze the relationship between plasma testosterone levels in men with both endothelial function (F) and ED. Methods. We enrolled 802 asymptomatic, intermediate cardiovascular risk patients, according to the Framingham Risk Score, aged 40 to 80 years, who underwent the study of EF, evaluation of ED and dosage of plasma testosterone. Results. At linear regression, EF (t=9.40; 95% CI from 0.9318 to 1.4234; p

Published
2014

37. Low levels of testosterone levels increase the risk of major cardiovascular events in a follow-up to 5 years

Author

NOVO, Salvatore, EVOLA, Vito, CORRADO, Egle, NOVO, Giuseppina, PAVONE, Carlo, Iacona, R, Bonomo, V, Di Piazza, M, Novo, S, Iacona, R, Bonomo, V, Di Piazza, M, Evola, V, Corrado, E, Novo, G, and Pavone, C

Subjects
TESTOSTERONE LEVELS, CARDIOVASCULAR RISK, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Settore MED/24 - Urologia
Abstract

Materials and Methods. We evaluated a series of 802 patients with intermediate cardiovascular risk according to the Framingham Risk Score (FRS). The endothelial function through flow-mediated vasodilatation (FMD), the erectile function (EF), and the total serum testosterone levels were assessed. Patients were followed for up to 5 years and the prevalence and predictors of MACEs were evaluated. Results. The levels of serum testosterone are related with both endothelial function (FMD) (t=9,4080, 95% CI= 0,9318 to 1,4234, p

Published
2014

40. Cognitive Semiotics and On-Line Reading of Religious Texts: A Hermeneutic Model of Sacred Literature and Everyday Revelation

Author

EVOLA, Vito and EVOLA V

Subjects
cognition, sacred texts, universals, literature, hermeneutics, religious, religious brain
Abstract

In this essay a hermeneutic model of the higher level understanding during on-line ritual reading by devotees of their respective sacred literatures is proposed, using the instruments provided by cognitive sciences. The way a devotee reads a sacred text differs from the way he or she would read a common piece of literature or how a lay person might read the same sacred text. After providing an overview of metaphor, anthropomorphism, and the “religious brain”, it is suggested how devotee-readers might make sense of a religious text and why it should be so important for their own personal everyday life. Universals are implicated in this genre of literature and the way it is interpreted.

Published
2005

41. The progression rate of aortic stenosis: key to tailoring the management and potential target for treatment.

Author

Tafciu E, Mandoli GE, Santoro C, Setti M, d'Andrea A, Esposito R, Bandera F, Evola V, Malagoli A, Cameli M, and Benfari G

Subjects
Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis mortality, Aortic Valve Stenosis therapy, Disease Progression, Echocardiography, Doppler, Humans, Prognosis, Risk Factors, Aortic Valve Stenosis physiopathology
Abstract

Aortic stenosis is the most frequent valvular disease to require intervention in the western world and has always been featured as a progressive disease. The rate of progression can be assessed by carefully performed Doppler echocardiography and can vary greatly between individuals with a profound impact on prognosis. Unfortunately, the determinants of disease progression had been insufficiently studied and remain challenging to define, particularly in the outpatient setting. Multiple factors have been proposed and tested, but at present, there are no proven therapies to slow the course of the stenotic process. Heart valve clinics may be particularly important to define the progression rate and tailor follow-up and management at an individual level. This review enlightens knowledge and gaps regarding the progression-rate of aortic valve stenosis, from the historical perspective to the molecular one., (Copyright © 2021 Italian Federation of Cardiology - I.F.C. All rights reserved.)

Published
2021
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42. Bicuspid aortic valve and sports: From the echocardiographic evaluation to the eligibility for sports competition.

Author

D'Ascenzi F, Valentini F, Anselmi F, Cavigli L, Bandera F, Benfari G, D'Andrea A, Di Salvo G, Esposito R, Evola V, Malagoli A, Elena Mandoli G, Santoro C, Galderisi M, Mondillo S, and Cameli M

Subjects
Aorta diagnostic imaging, Aorta pathology, Bicuspid Aortic Valve Disease pathology, Bicuspid Aortic Valve Disease physiopathology, Dilatation, Pathologic, Echocardiography, Doppler, Exercise physiology, Humans, Physical Conditioning, Human physiology, Bicuspid Aortic Valve Disease diagnostic imaging, Competitive Behavior physiology, Eligibility Determination, Sports physiology
Abstract

Bicuspid aortic valve (BAV) is the most common congenital heart defect in adults. Although a BAV may remain without clinical consequences for a lifetime, it can deteriorate in aortic valve stenosis and regurgitation and aortic dilatation. Unfortunately, the impact of regular training on patients with BAV and its natural course is not fully understood, although preliminary evidence suggests that the progression of valvular disease occurs primarily in an independent manner from sports practice. The current review aims to report how to perform a comprehensive echocardiographic examination in athletes with BAV and analyze the current literature on the influence of sports practice and how it impacts the aortic valve in athletes with BAV. The article also summarizes the current recommendations on sports eligibility and disqualification for competitive athletes with BAV., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2021
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43. Usefulness of Stress Echocardiography in the Management of Patients Treated with Anticancer Drugs.

Author

Novo G, Santoro C, Manno G, Di Lisi D, Esposito R, Mandoli GE, Evola V, Pastore MC, Sperlongano S, D'Andrea A, Cameli M, and Galderisi M

Subjects
Cardiotoxicity, Early Detection of Cancer, Echocardiography, Echocardiography, Stress, Humans, Antineoplastic Agents adverse effects, Neoplasms drug therapy
Abstract

In recent years, the survival of patients with cancer has improved thanks to advances in antineoplastic therapeutic protocols. This has led to an increasing burden of cardiovascular complications related to cancer treatment. Therefore, a new branch of cardiology has been created, "cardio-oncology," with the aims of preventing cardiovascular complications related to antineoplastic treatment, achieving early diagnosis and treatment of any complications, and allowing completion of the expected antineoplastic treatment. Stress echocardiography has a pivotal role in achieving a timely diagnosis of coronary artery disease and thus is the best management approach in this clinical setting. Atherosclerotic processes can be exacerbated by both chemotherapy and chest irradiation in patients with cancer, even several years after anticancer treatment completion. Moreover, stress echocardiography has many other potential applications, such as in the evaluation of subclinical left ventricular dysfunction and contractile reserve in patients treated with anticancer drugs that have the potential to induce myocardial damage, as well as evaluating valve disease. The objective of this review is to delineate the role of stress echocardiography in cardio-oncology., (Copyright © 2020 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)

Published
2021
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44. Basic and advanced echocardiography in advanced heart failure: an overview.

Author

Pastore MC, Mandoli GE, Aboumarie HS, Santoro C, Bandera F, D'Andrea A, Benfari G, Esposito R, Evola V, Sorrentino R, Cameli P, Valente S, Mondillo S, Galderisi M, and Cameli M

Subjects
Heart Failure physiopathology, Heart Ventricles physiopathology, Humans, Echocardiography methods, Heart Failure diagnosis, Heart Ventricles diagnostic imaging, Stroke Volume physiology
Abstract

Advanced chronic heart failure (ACHF) is the last phase in the evolution of heart failure and is characterized by high hospitalization and mortality rates and is refractory to medical therapy, therefore requiring more aggressive therapies, such as mechanical circulatory support or heart transplantation. Over the last years, the incidence of ACHF was continuously growing, together with the increase in population survival rates. Therefore, the early recognition of the transition to ACHF is of crucial importance in HF patients, which also helps in prognostication of such patients, since advanced therapeutic options are limited to selected patients and they also have some important risk implications. Echocardiography is the gold standard tool for the evaluation of patients with HF; moreover, the recent technological advances provided new structural and functional indices of the four cardiac chambers that showed to be comparable to advanced imaging or invasive hemodynamic parameters. This allows us to operate an accurate study of ACHF with first- and second-level echocardiographic techniques, which are now being integrated in daily clinical practice. The present review presents an overview of the currently available tools for the echocardiographic examination of patients with ACHF, with its advantages and limitations, based on the latest supporting evidences.

Published
2020
Full Text
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45. Speckle tracking evaluation in endurance athletes: the "optimal" myocardial work.

Author

D'Andrea A, Radmilovic J, Carbone A, Mandoli GE, Santoro C, Evola V, Bandera F, D'Ascenzi F, Bossone E, Galderisi M, and Cameli M

Subjects
Adult, Case-Control Studies, Exercise Tolerance, Female, Humans, Male, Observer Variation, Predictive Value of Tests, Prospective Studies, Reproducibility of Results, Stroke Volume, Time Factors, Athletes, Echocardiography, Doppler, Echocardiography, Stress, Exercise Test, Heart Ventricles diagnostic imaging, Myocardial Contraction, Physical Endurance, Tinea Pedis, Ventricular Function, Left, Ventricular Remodeling
Abstract

To analyze left ventricular myocardial deformation and contractile reserve in endurance athletes at rest and during exercise, and their possible correlations with functional capacity. The athlete's heart in endurance training is characterized by physiologic eccentric remodeling, with left ventricle adaptation at rest and echocardiographic parameters at low end of normality. Assessment of left ventricle systolic function and contractile reserve has an important role in the decision-making and in differential diagnosis with cardiomyopathies. Standard echo, lung ultrasound, left ventricle 2D speckle-tracking strain and myocardial work were performed at rest and during exercise in endurance athletes and in age- and sex-comparable healthy controls. 350 endurance athletes (male sex 58.5%; 31.6 ± 4.2 years) and 150 healthy controls were enrolled. Left ventricular ejection fraction at baseline was comparable between the two groups. Resting left ventricular global longitudinal strain was reduced in endurance athletes (- 18.4 ± 2.6% vs. - 22.4 ± 3.3% in controls; p < 0.01). Myocardial work efficiency did not show significative difference between the two groups. At peak exertion during exercise stress echocardiography, endurance athletes showed better exercise capacity and peak VO 2 consumption (58.6 ± 10.2 ml/kg/min vs 38.6 ± 3.3 ml/kg/min in controls, p < 0.0001), associated with a preserved contractile reserve and augmented pulmonary artery systolic pressure. By multivariable analysis myocardial work efficiency at rest was closely related to maximal watts (p < 0.0001), peak VO 2 , (p < 0.0001), left ventricular E/e' (p < 0.001) and number of B-lines (p < 0.001), all measured at peak effort. Myocardial work efficiency shows less load-dependency than global longitudinal strain. Normal resting values of myocardial work efficiency in endurance athletes suggest a physiological remodeling, associated with a better exercise capacity and preserved contractile reserve during physical effort.

Published
2020
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46. Metaphor processing is supramodal semantic processing: The role of the bilateral lateral temporal regions in multimodal communication.

Author

Joue G, Boven L, Willmes K, Evola V, Demenescu LR, Hassemer J, Mittelberg I, Mathiak K, Schneider F, and Habel U

Subjects
Adolescent, Adult, Cognition physiology, Comprehension physiology, Female, Humans, Magnetic Resonance Imaging methods, Male, Photic Stimulation methods, Speech physiology, Temporal Lobe physiology, Young Adult, Communication, Gestures, Metaphor, Reaction Time physiology, Semantics, Temporal Lobe diagnostic imaging
Abstract

This paper presents an fMRI study on healthy adult understanding of metaphors in multimodal communication. We investigated metaphors expressed either only in coverbal gestures ("monomodal metaphors") or in speech with accompanying gestures ("multimodal metaphors"). Monomodal metaphoric gestures convey metaphoric information not expressed in the accompanying speech (e.g. saying the non-metaphoric utterance, "She felt bad" while dropping down the hand with palm facing up; here, the gesture alone indicates metaphoricity), whereas coverbal gestures in multimodal metaphors indicate metaphoricity redundant to the speech (e.g. saying the metaphoric utterance, "Her spirits fell" while dropping the hand with palm facing up). In other words, in monomodal metaphors, gestures add information not spoken, whereas the gestures in multimodal metaphors can be redundant to the spoken content. Understanding and integrating the information in each modality, here spoken and visual, is important in multimodal communication, but most prior studies have only considered multimodal metaphors where the gesture is redundant to what is spoken. Our participants watched audiovisual clips of an actor speaking while gesturing. We found that abstract metaphor comprehension recruited the lateral superior/middle temporal cortices, regardless of the modality in which the conceptual metaphor is expressed. These results suggest that abstract metaphors, regardless of modality, involve resources implicated in general semantic processing and are consistent with the role of these areas in supramodal semantic processing as well as the theory of embodied cognition., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2020
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47. Identification of cardiac organ damage in arterial hypertension: insights by echocardiography for a comprehensive assessment.

Author

Cameli M, Lembo M, Sciaccaluga C, Bandera F, Ciccone MM, D'Andrea A, D'Ascenzi F, Esposito R, Evola V, Liga R, Mandoli GE, Palmiero P, Santoro C, Scicchitano P, Sorrentino R, Zito A, Pedrinelli R, Mondillo S, Mattioli AV, and Galderisi M

Subjects
Humans, Hypertension physiopathology, Prognosis, Aortic Valve diagnostic imaging, Echocardiography methods, Heart Ventricles diagnostic imaging, Hypertension diagnostic imaging
Abstract

: Arterial hypertension, a widespread disease, whose prevalence increases with age, represents a major risk factor for cardiovascular events, causing damage in several organs, including the heart. In this context, echocardiography has a clear and pivotal role, being able to assess cardiac morphology and detect haemodynamic changes induced by this disease. 2018 European Society of Cardiology/European Society of Hypertension guidelines on AH identified main echo parameters such as left ventricular mass, relative wall thickness and left atrial volume, for detecting cardiac organ damage. The present review highlights the advantage of additional echocardiographic parameters such as diastolic measurement and both thoracic and abdominal aortic dimensions. An overlook on aortic valve should also be suggested to detect aortic regurgitation and stenosis, both frequent complications in hypertensive patients. In this kind of comprehensive assessment, the combination of standard and advanced echocardiography (speckle tracking echocardiography and, with a lesser extent, three-dimensional echocardiography) could be considered to improve the diagnostic accuracy, stratify prognosis and address management in arterial hypertension.

Published
2020
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48. [Stress echocardiography of the righ heart-pulmonary circulation unit: rationale and possibilities of application in clinical practice].

Author

Sperlongano S, D'Andrea A, Mele D, Mandoli GE, Sorrentino R, Esposito R, Evola V, Bandera F, D'Alto M, Bossone E, Galderisi M, and Cameli M

Subjects
Heart Diseases physiopathology, Heart Ventricles diagnostic imaging, Humans, Lung Diseases physiopathology, Prognosis, Pulmonary Circulation, Echocardiography, Stress methods, Heart Diseases diagnostic imaging, Lung Diseases diagnostic imaging
Abstract

The right heart has been traditionally considered a passive conduit between the venous system and the lungs. Today, we know that a close hemodynamic interdependence exists between right ventricle, pulmonary circulation, and left ventricle, and that the right ventricle plays a key role in the ability to adapt to many super-physiological and pathological conditions. Dynamic exercise is a considerable stress for the "right heart-pulmonary circulation unit", which responds, in healthy subjects, with an increase of right ventricular contractility and cardiac output, a decrease of pulmonary vascular resistance, and a non-significant rise in pulmonary pressures. In patients affected by cardiac and/or pulmonary diseases (e.g. ischemic heart disease, heart failure, severe valvular stenosis or regurgitation, systemic sclerosis, chronic obstructive pulmonary disease, etc.) right ventricular contractile reserve may be impaired, and pulmonary artery systolic pressure may abnormally increase during exercise. From this perspective, stress echocardiography is a primary tool to evaluate right ventricle and pulmonary circulation during exercise, and can be useful in setting diagnosis, prognosis, and therapeutic timing of many cardiopulmonary diseases.

Published
2019
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49. Long-term parameters of heart rate variability in patients with insulin-resistance.

Author

Novo G, Manno G, Levantino P, Cangemi S, Evola V, GiustinaVitale, Evola S, Luparelli M, and Novo S

Subjects
Aged, Biomarkers blood, Blood Glucose metabolism, Female, Humans, Insulin blood, Male, Metabolic Syndrome blood, Metabolic Syndrome diagnosis, Middle Aged, Pilot Projects, Retrospective Studies, Time Factors, Heart Rate, Insulin Resistance, Metabolic Syndrome physiopathology
Published
2019
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50. Coordinated Collaboration and Nonverbal Social Interactions: A Formal and Functional Analysis of Gaze, Gestures, and Other Body Movements in a Contemporary Dance Improvisation Performance.

Author

Evola V and Skubisz J

Abstract

This study presents a microanalysis of what information performers "give" and "give off" to each other via their bodies during a contemporary dance improvisation. We compare what expert performers and non-performers (sufficiently trained to successfully perform) do with their bodies during a silent, multiparty improvisation exercise, in order to identify any differences and to provide insight into nonverbal communication in a less conventional setting. The coordinated collaboration of the participants (two groups of six) was examined in a frame-by-frame analysis focusing on all body movements, including gaze shifts as well as the formal and functional movement units produced in the head-face, upper-, and lower-body regions. The Methods section describes in detail the annotation process and inter-rater agreement. The results of this study indicate that expert performers during the improvisation are in "performance mode" and have embodied other social cognitive strategies and skills (e.g., endogenous orienting, gaze avoidance, greater motor control) that the non-performers do not have available. Expert performers avoid using intentional communication, relying on information to be inferentially communicated in order to coordinate collaboratively, with silence and stillness being construed as meaningful in that social practice and context. The information that expert performers produce is quantitatively less (i.e., producing fewer body movements) and qualitatively more inferential than intentional compared to a control group of non-performers, which affects the quality of the performance., Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest., (© The Author(s) 2019.)

Published
2019
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