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2. Original article Distribution of HBV genotypes in Poland

Author

Marta Wawrzynowicz-Syczewska, Robert Flisiak, Ewelina Zasik, Magdalena Świderska, Jerzy Jaroszewicz, Elzbieta Murias-Brylowska, Małgorzata Pawłowska, Anna Piekarska, Waldemar Halota, Krzysztof Simon, Krzysztof Tomasiewicz, Anna Pniewska, Włodzimierz Mazur, and Paweł Rajewski

Subjects
medicine.medical_specialty, Veterinary medicine, Hepatology, Current distribution, Epidemiology, Genotype, Hbv genotype, medicine, Prevalence, Biology, Virology, Regional differences
Abstract

Aim of the study To identify distribution of HBV genotypes in particular regions of Poland. Material and methods The study included 270 treatment-naive, HBV-infected individuals, enrolled in 7 centers of Poland. HBV genotyping was performed in 243 of them with the INNO-LiPA HBV Genotyping assay (Innogenetics). Results Genotype A present in 2/3 patients was demonstrated as the most predominant in Poland. It was followed by D (20%), H (5%) and mixed A + D (5%). Remaining patients were infected with genotype F, mixed D + G, A + C or D + F. Analysis of distribution demonstrated regional differences, with a higher rate of genotype D prevalence (about 30%) in the eastern (Bialystok and Lublin) and south-western (Wroclaw) parts compared to other regions, where the prevalence rate was below 15%. The highest prevalence of genotype A (exceeding 80%) was observed in central Poland (Bydgoszcz, Łodź). Conclusions The presented data reveal the current distribution of HBV genotypes across Poland, which is the first and the largest such epidemiological analysis.

Published
2015
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3. Meeting the WHO 90% target: antiretroviral treatment efficacy in Poland is associated with baseline clinical patient characteristics

Author

Anita Olczak, Karolina Muller, Bartosz Szetela, Andrzej Horban, Aleksandra Kocbach, Tomasz Mikuła, Wiesława Błudzin, Maria Jankowska, Monika Bociąga-Jasik, Justyna Stempkowska, Małgorzata Janczarek, Iwona Cielniak, Magdalena Leszczyszyn-Pynka, Ewelina Zasik, Magdalena Witak-Jędra, Małgorzata Lemańska, Ewa Firląg Burkacka, Ewa Siwak, Miłosz Parczewski, Edyta Grąbczewska, Anna Grzeszczuk, Dagny Krankowska, Kamila Wójcik-Cichy, Jacek Gąsiorowski, Katarzyna Kozieł, Dariusz Bielec, Paweł Skwara, Adam Witor, Elżbieta Jabłonowska, Juliusz Kamerys, Piotr Pulik, and Aleksandra Szymczak

Subjects
0301 basic medicine, antiretroviral treatment, Male, Lymphocyte, HIV Infections, Pharmacology, Gastroenterology, Serology, 0302 clinical medicine, 030212 general & internal medicine, Young adult, Univariate analysis, Age Factors, Middle Aged, Viral Load, Infectious Diseases, medicine.anatomical_structure, Treatment Outcome, Drug Therapy, Combination, Female, Viral load, Research Article, Cart, Adult, medicine.medical_specialty, virologic suppression, Anti-HIV Agents, 030106 microbiology, World Health Organization, Article, 03 medical and health sciences, Young Adult, Acquired immunodeficiency syndrome (AIDS), Internal medicine, medicine, Antiretroviral treatment, Humans, business.industry, Public Health, Environmental and Occupational Health, cART efficacy, medicine.disease, WHO target, CD4 Lymphocyte Count, Health Planning, Cross-Sectional Studies, virologic control, HIV-1, viral replication, Poland, business
Abstract

Introduction : Modern combined antiretroviral therapies (cART) allow to effectively suppress HIV-1 viral load, with the 90% virologic success rate, meeting the WHO target in most clinical settings. The aim of this study was to analyse antiretroviral treatment efficacy in Poland and to identify variables associated with virologic suppression. M ethods : Cross-sectional data on 5152 (56.92% of the countrywide treated at the time-point of analysis) patients on cART for more than six months with at least one HIV-RNA measurement in 2016 were collected from 14 Polish centres. Patients’ characteristics and treatment type-based outcomes were analysed for the virologic suppression thresholds of

Published
2017

4. Distribution of HCV genotypes in Poland = Występowanie genotypów HCV w Polsce

Author

Anatol Panasiuk, Robert Flisiak, Iwona Mozer-Lisewska, Agnieszka Adamek, Małgorzata Tyczyno, Waldemar Halota, Małgorzata Pawłowska, Janusz Stańczak, Hanna Berak, Marta Wawrzynowicz-Syczewska, Anna Boroń-Kaczmarska, Tadeusz Wojciech Łapiński, Anna Grzeszczuk, Anna Piekarska, Krzysztof Tomasiewicz, Maciej Jabłkowski, Wiesław Kryczka, Dorota Zarębska-Michaluk, Piotr Stępień, Aleksander Michał Garlicki, Joanna Kozłowska, Alicja Wiercińska-Drapało, Ewelina Zasik, Waldemar Mazur, Beata Dobracka, Witold Dobracki, Krzysztof Simon, Józef Ryżko, Joanna Pawłowska, Katarzyna Dzierżanowska-Fangrat, Danuta Januszkiewicz-Lewandowska, Leszek Szenborn, Izabela Zaleska, Maria Rokitka, Elżbieta Strawińska, Katarzyna Balinowska, Tomasz Smiatacz, Piotr Stalke, Katarzyna Sikorska, Anna Lakomy, Maciej Zdrojewski, and Anna Lachowicz

5. Poland. Estimating the HIV viral suppression rate: a national study

Author

Miłosz Parczewski, Magdalena Leszczyszyn-Pynka, Magdalena Witak-Jędra, Ewa Siwak, Iwona Cielniak, Ewa Burkacka, Piotr Pulik, Andrzej Horban, Adam Witor, Karolina Muller, Ewelina Zasik, Anna Grzeszczuk, Małgorzata Janczarek, Maria Jankowska, Małgorzata Lemańska, Anita Olczak, Edyta Grąbczewska, Aleksandra Szymczak, Tomasz Mikuła, Jacek Gąsiorowski, Bartosz Szetela, Monika Bociąga-Jasik, Paweł Skwara, Elżbieta Jabłonowska, Kamila Wójcik-Cichy, Juliusz Kamerys, Dagny Krankowska, Katarzyna Kozieł, Dariusz Bielec, Justyna Stempkowska, Aleksandra Kocbach, and Wiesława Błudzin

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