215 results on '"Ewing, William R."'
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2. Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities
3. Milvexian, an orally bioavailable, small‐molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits
4. Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation
5. Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials
6. Ligand Enabled Pd(II)-Catalyzed γ-C(sp3)–H Lactamization of Native Amides
7. Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy
8. Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor
9. A tautomeric ligand enables directed C‒H hydroxylation with molecular oxygen
10. Control of Angiogenesis with Synthetic Heparin Substitutes
11. Site-Selective Functionalization of Methionine Residues via Photoredox Catalysis
12. Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability
13. Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors
14. Ligand Enabled Pd(II)-Catalyzed γ‑C(sp3)–H Lactamization of Native Amides.
15. Cannabinoid CB1 receptor ligand binding and function examined through mutagenesis studies of F200 and S383
16. meta ‐Selective C−H Arylation of Fluoroarenes and Simple Arenes
17. Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species
18. Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis
19. Ligand-Enabled Pd(II)-Catalyzed C(sp3)–H Lactonization Using Molecular Oxygen as Oxidant
20. PdII‐Catalyzed Enantioselective C(sp3)–H Arylation of Cyclobutyl Ketones Using a Chiral Transient Directing Group
21. Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis
22. β ‐Selective C−H Arylation of Electron‐Deficient Thiophenes, Pyrroles, and Furans
23. Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups
24. Exploration of structure–activity relationships at the two C-terminal residues of potent 11mer Glucagon-Like Peptide-1 receptor agonist peptides via parallel synthesis
25. Anti-Markovnikov Hydroamination of Unactivated Alkenes with Primary Alkyl Amines
26. Manganese-Catalyzed Desaturation of N-Acyl Amines and Ethers
27. Identification of potent 11mer Glucagon-Like Peptide-1 Receptor agonist peptides with novel C-terminal amino acids: Homohomophenylalanine analogs
28. Hemilabile Benzyl Ether Enables γ-C(sp3)–H Carbonylation and Olefination of Alcohols
29. meta C–H Arylation of Electron-Rich Arenes: Reversing the Conventional Site Selectivity
30. In Praise of Remarkably Powerful Centamolecular Therapeutic Agents
31. Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer
32. Overcoming the Limitations of γ- and δ-C–H Arylation of Amines through Ligand Development
33. Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency
34. Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists
35. Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)
36. PdII‐Catalyzed Enantioselective C(sp3)–H Arylation of Cyclobutyl Ketones Using a Chiral Transient Directing Group.
37. Hemilabile Benzyl Ether Enables γ‑C(sp3)–H Carbonylation and Olefination of Alcohols.
38. Factor XIa Inhibitors as New Anticoagulants
39. Ni-Catalyzed Carbon–Carbon Bond-Forming Reductive Amination
40. Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists
41. Selective C−H Halogenation with a Highly Fluorinated Manganese Porphyrin
42. Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials
43. Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)
44. Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors
45. Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode
46. Abstract TMP117: Preclinical and Early Clinical Characterization of a Parenterally Administered Direct Factor XIa Inhibitor
47. Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups
48. metaC–H Arylation of Electron-Rich Arenes: Reversing the Conventional Site Selectivity
49. Aminoisoquinolines: Design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA
50. Design and Structure−Activity Relationships of Potent and Selective Inhibitors of Blood Coagulation Factor Xa
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