19 results on '"Ewings, Fiona"'
Search Results
2. Antiretroviral resistance at virological failure in the NEAT 001/ANRS 143 trial: raltegravir plus darunavir/ritonavir or tenofovir/emtricitabine plus darunavir/ritonavir as first-line ART
- Author
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Lambert-Niclot, S., George, E. C., Pozniak, A., White, E., Schwimmer, C., Jessen, H., Johnson, M., Dunn, D., Perno, C. F., Clotet, B., Plettenberg, A., Blaxhult, A., Palmisano, L., Wittkop, L., Calvez, V., Marcelin, A. G., Raffi, F., Dedes, Nikos, Chêne, Geneviève, Richert, Laura, Allavena, Clotilde, Raffi, François, Autran, Brigitte, Antinori, Andrea, Bucciardini, Raff aella, Vella, Stefano, Horban, Andrzej, Arribas, Jose, Babiker, Abdel G., Boffito, Marta, Pillay, Deenan, Pozniak, Anton, Franquet, Xavier, Schwarze, Siegfried, Grarup, Jesper, Chêne, Geneviève, Fischer, Aurélie, Richert, Laura, Wallet, Cédrick, Raffi, François, Diallo, Alpha, Molina, Jean-Michel, Saillard, Juliette, Moecklinghoff, Christiane, Stellbrink, Hans-Jürgen, Vella, Stefano, Van Leeuwen, Remko, Gatell, Jose, Sandstrom, Eric, Flepp, Markus, Babiker, Abdel G, Ewings, Fiona, George, Elizabeth C., Hudson, Fleur, Pozniak, Anton, Pearce, Gillian, Quercia, Romina, Rogatto, Felipe, Leavitt, Randi, Nguyen, Bach-Yen, Goebel, Frank, Marcotullio, Simone, Babiker, Abdel G., Ewings, Fiona, George, Elizabeth C., Hudson, Fleur, Kaur, Navrup, Sasieni, Peter, Spencer-Drake, Christina, Peto, Tim, Miller, Veronica, Allavena, Clotilde, Raffi, François, Vella, Stefano, Pozniak, Anton, Arnault, Fabien, Boucherie, Céline, Fischer, Aurélie, Jean, Delphine, Paniego, Observer Virginie, Paraina, Felasoa, Richert, Laura, Rouch, Elodie, Schwimmer, Christine, Soussi, Malika, Taieb, Audrey, Termote, Monique, Touzeau, Guillaume, Wallet, Cédrick, Babiker, Abdel G., Cursley, Adam, Dodds, Wendy, Ewings, Fiona, George, Elizabeth C., Hoppe, Anne, Hudson, Fleur, Kummeling, Ischa, Pacciarini, Filippo, Paton, Nick, Russell, Charlotte, Taylor, Kay, Ward, Denise, Aagaard, Bitten, Eid, Marius, Gey, Daniela, Jensen, Birgitte Gram, Grarup, Jesper, Jakobsen, Marie-Louise, Jansson, Per O., Jensen, Karoline, Joensen, Zillah Maria, Larsen, Ellen Moseholm, Pahl, Christiane, Pearson, Mary, Nielsen, Birgit Riis, Reilev, Søren Stentoft, Christ, Ilse, Lathouwers, Desiree, Manting, Corry, Van Leeuwen, Remko, Diallo, Alpha, Mendy, Bienvenu Yves, Metro, Annie, Saillard, Juliette, Couffin-Cadiergues, Sandrine, Knellwolf, Anne-Laure, Palmisiano, Lucia, Aznar, Esther, Barea, Cristina, Cotarelo, Manuel, Esteban, Herminia, Girbau, Iciar, Moyano, Beatriz, Ramirez, Miriam, Saiz, Carmen, Sanchez, Isabel, Yllescas, Maria, Binelli, Andrea, Colasanti, Valentina, Massella, Maurizio, Palmisiano, Lucia, Anagnostou, Olga, Gioukari, Vicky, Touloumi, Giota, Schmied, Brigitte, Rieger, Armin, Vetter, Norbert, De Wit, Stephane, Florence, Eric, Vandekerckhove, Linos, Gerstoft, Jan, Mathiesen, Lars, Katlama, Christine, Cabie, Andre, Cheret, Antoine, Dupon, Michel, Ghosn, Jade, Girard, Pierre-Marie, Goujard, Cécile, Lévy, Yves, Molina, Jean-Michel, Morlat, Philippe, Neau, Didier, Obadia, Martine, Perre, Philippe, Piroth, Lionel, Reynes, Jacques, Tattevin, Pierre, Raffi, François, Ragnaud, Jean Marie, Weiss, Laurence, Yazdan, Yazdanpanah, Yeni, Patrick, Zucman, David, Behrens, Georg, Esser, Stefan, Fätkenheuer, Gerd, Hoffmann, Christian, Jessen, Heiko, Rockstroh, Jürgen, Schmidt, Reinhold, Stephan, Christoph, Unger, Stefan, Hatzakis, Angelos, Daikos, George L., Papadopoulos, Antonios, Skoutelis, Athamasios, Banhegyi, Denes, Mallon, Paddy, Mulcahy, Fiona, Antinori, Andrea, Andreoni, Massimo, Bonora, Stefano, Castelli, Francesco, Monforte, Antonella DʼArminio, Di Perri, Giovanni, Galli, Massimo, Lazzarin, Adriano, Mazzotta, Francesco, Carlo, Torti, Vullo, Vincenzo, Prins, Jan, Richter, Clemens, Verhagen, Dominique, Van Eeden, Arne, Horban, Andrzej, Doroana, Manuela, Antunes, Francisco, Maltez, Fernando, Sarmento-Castro, Rui, Garcia, Juan Gonzalez, Aldeguer, José López, Clotet, Bonaventura, Domingo, Pere, Gatell, Jose M., Knobel, Hernando, Marquez, Manuel, Miralles, Martin Pilar, Portilla, Joaquin, Soriano, Vicente, Tellez, Maria-Jesus, Thalme, Anders, Blaxhult, Anders, Gisslen, Magnus, Winston, Alan, Fox, Julie, Gompels, Mark, Herieka, Elbushra, Johnson, Margaret, Leen, Clifford, Pozniak, Anton, Teague, Alastair, Williams, Ian, Boyd, Mark Alastair, Grarup, Jesper, Jansson, Per O., Møller, Nina Friis, Larsen, Ellen Frøsig Moseholm, Morlat, Philippe, Piroth, Lionel, Le Moing, Vincent, Wit, Ferdinand W. N. M., Kowalska, Justyna, Berenguer, Juan, Moreno, Santiago, Müller, Nicolas J., Török, Estée, Post, Frank, Angus, Brian, Calvez, Vincent, Boucher, Charles, Collins, Simon, Dunn, David, Lambert, Sidonie, Marcelin, Anne-Geneviève, Perno, Carlo Federico, Pillay, Deenan, White, Ellen, Boffito, Marta, Ammassari, Adriana, Antinori, Andrea, Stoehr, Wolgang, Autran, Brigitte, Schmidt, Reinhold Ernst, Odermarsky, Michal, Smith, Colette, Thiébaut, Rodolphe, Arribas, Jose, De La Serna, Jose Ignacio Bernardino, Castagna, Antonella, De Wit, Stephane, Franquet, Xavier, Furrer, Hans-Jackob, Katlama, Christine, Mocroft, Amanda, Reiss, Peter, Bucciardini, Raffaella, Dedes, Nikos, Fragola, Vincenzo, George, Elizabeth C., Lauriola, Marco, Murri, Rita, Nieuwkerk, Pythia, Spire, Bruno, Volny-Anne, Alain, West, Brian, Amieva, Hélène, Antinori, Andrea, Llibre Codina, Josep Maria, Richert, Laura, Stoehr, Wolgang, Winston, Alan, Castelli, Francesco, Braggion, Marco, and Focà, Emanuele
- Published
- 2016
- Full Text
- View/download PDF
3. HIV-1-specific CD4+ responses in primary HIV-1 infection predict disease progression
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Frater, John, Ewings, Fiona, Hurst, Jacob, Brown, Helen, Robinson, Nicola, Fidler, Sarah, Babiker, Abdel, Weber, Jonathan, Porter, Kholoud, and Phillips, Rodney E.
- Published
- 2014
- Full Text
- View/download PDF
4. Patient-Reported Outcomes in First-Line Antiretroviral Therapy: Results From NEAT001/ANRS143 Trial Comparing Darunavir/Ritonavir in Combination With Tenofovir/Emtricitabine or Raltegravir
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George, Elizabeth C. Bucciardini, Raffaella Richert, Laura and Dedes, Nikos Fragola, Vincenzo Nieuwkerk, Pythia Spire, Bruno Volny-Anne, Alain West, Brian Molina, Jean-Michel and Horban, Andrzej Fox, Julie Pozniak, Anton Vella, Stefano and Termote, Monique Raffi, Francois Chene, Genevieve Allavena, Clotilde Autran, Brigitte Antinori, Andrea Arribas, Jose and Babiker, Abdel G. Boffito, Marta Pillay, Deenan Franquet, Xavier Schwarze, Siegfried Grarup, Jesper Fischer, Aurelie and Wallet, Cedrick Diallo, Alpha Saillard, Juliette and Moecklinghoff, Christiane Stellbrink, Hans-Jurgen Van Leeuwen, Remko Gatell, Jose Sandstrom, Eric Flepp, Markus and Babiker, Abdel G. Ewings, Fiona Hudson, Fleur Pearce, Gillian Quercia, Romina Rogatto, Felipe Leavitt, Randi and Nguyen, Bach-Yen Allavena, Clotilde Arnault, Fabien Fischer, Aurelie Paniego, Virginie Schwimmer, Christine Touzeau, Guillaume Wallet, Cedrick Boucherie, Celine Jean, Delphine and Paraina, Felasoa Rouch, Elodie Soussi, Malika Taieb, Audrey Babiker, Abdel G. Ewings, Fiona Dodds, Wendy and Hudson, Fleur Cursley, Adam Hoppe, Anne Kummeling, Ischa and Pacciarini, Filippo Paton, Nick Russell, Charlotte Taylor, Kay Ward, Denise Gey, Daniela Jansson, Per O. Jensen, Karoline Pearson, Mary Nielsen, Birgit Riis Aagaard, Bitten and Eid, Marius Jensen, Birgitte Gram Jakobsen, Marie-Louise and Joensen, Zillah Maria Larsen, Ellen Moseholm Pahl, Christiane and Reilev, Soren Stentoft Lathouwers, Desiree Manting, Corry and Van Leeuwen, Remko Christ, Ilse Diallo, Alpha Mendy, Bienvenu Yves Metro, Annie Saillard, Juliette and Couffin-Cadiergues, Sandrine Palmisiano, Lucia Knellwolf, Anne-Laure Aznar, Esther Barea, Cristina Cotarelo, Manuel and Esteban, Herminia Girbau, Iciar Moyano, Beatriz Ramirez, Miriam Saiz, Carmen Sanchez, Isabel Yllescas, Maria and Binelli, Andrea Colasanti, Valentina Massella, Maurizio and Palmisiano, Lucia Anagnostou, Olga Gioukari, Vicky Touloumi, Giota Schmied, Brigitte Rieger, Armin Vetter, Norbert De Wit, S and George, Elizabeth C. Bucciardini, Raffaella Richert, Laura and Dedes, Nikos Fragola, Vincenzo Nieuwkerk, Pythia Spire, Bruno Volny-Anne, Alain West, Brian Molina, Jean-Michel and Horban, Andrzej Fox, Julie Pozniak, Anton Vella, Stefano and Termote, Monique Raffi, Francois Chene, Genevieve Allavena, Clotilde Autran, Brigitte Antinori, Andrea Arribas, Jose and Babiker, Abdel G. Boffito, Marta Pillay, Deenan Franquet, Xavier Schwarze, Siegfried Grarup, Jesper Fischer, Aurelie and Wallet, Cedrick Diallo, Alpha Saillard, Juliette and Moecklinghoff, Christiane Stellbrink, Hans-Jurgen Van Leeuwen, Remko Gatell, Jose Sandstrom, Eric Flepp, Markus and Babiker, Abdel G. Ewings, Fiona Hudson, Fleur Pearce, Gillian Quercia, Romina Rogatto, Felipe Leavitt, Randi and Nguyen, Bach-Yen Allavena, Clotilde Arnault, Fabien Fischer, Aurelie Paniego, Virginie Schwimmer, Christine Touzeau, Guillaume Wallet, Cedrick Boucherie, Celine Jean, Delphine and Paraina, Felasoa Rouch, Elodie Soussi, Malika Taieb, Audrey Babiker, Abdel G. Ewings, Fiona Dodds, Wendy and Hudson, Fleur Cursley, Adam Hoppe, Anne Kummeling, Ischa and Pacciarini, Filippo Paton, Nick Russell, Charlotte Taylor, Kay Ward, Denise Gey, Daniela Jansson, Per O. Jensen, Karoline Pearson, Mary Nielsen, Birgit Riis Aagaard, Bitten and Eid, Marius Jensen, Birgitte Gram Jakobsen, Marie-Louise and Joensen, Zillah Maria Larsen, Ellen Moseholm Pahl, Christiane and Reilev, Soren Stentoft Lathouwers, Desiree Manting, Corry and Van Leeuwen, Remko Christ, Ilse Diallo, Alpha Mendy, Bienvenu Yves Metro, Annie Saillard, Juliette and Couffin-Cadiergues, Sandrine Palmisiano, Lucia Knellwolf, Anne-Laure Aznar, Esther Barea, Cristina Cotarelo, Manuel and Esteban, Herminia Girbau, Iciar Moyano, Beatriz Ramirez, Miriam Saiz, Carmen Sanchez, Isabel Yllescas, Maria and Binelli, Andrea Colasanti, Valentina Massella, Maurizio and Palmisiano, Lucia Anagnostou, Olga Gioukari, Vicky Touloumi, Giota Schmied, Brigitte Rieger, Armin Vetter, Norbert De Wit, S
- Abstract
Background: There are few data comparing patient-reported outcomes (PROs) in randomized trials of initial antiretroviral therapy. We present results from a substudy of the NEAT001/ ANRS143 trial. Methods: The randomized trial compared first-line DRV/r 800/100 mg once daily plus RAL 400 mg twice daily and DRV/r plus TDF/ FTC 245/200 mg once daily. Changes in PROs were assessed with 3 questionnaires: EuroQoL 5 domains (EQ-5D), Center for Epidemiologic Studies Depression (CES-D) scale, and HIV Treatment Satisfaction Questionnaire. Major depressive disorder (MDD) was defined as CES-D $ 16. General estimating equations were used to model change over 96 weeks in PROs from baseline. Results: Of the 805 participants, 797 (99%) contributed to the substudy. Baseline PRO data were similar for the 2 randomized groups. Health status improved over time with a mean increase in EQ-5D visual analogue scale (VAS) of 8.0 by W96 [95% confidence interval (CI): 6.5 to 9.4; P, 0.001], and no statistically significant differences between groups (difference of 0.3 on VAS score (95% CI: 21.7 to 2.3); P = 0.7, global P value $ 0.05 for all domains over follow-up). There was no significant difference between groups on CES-D [difference of 20.1 (95% CI: 21.3 to 1.1); P = 0.9], or MDD during follow-up, adjusted for baseline MDD (odds ratio = 0.98, 95% CI: 0.82 to 1.18; P = 0.9). RAL + DRV/r group had lower level of convenience (P = 0.03) and fitted less well into patients’ lifestyle (P = 0.007) than the TDF/FTC + DRV/r regimen, and was associated with lower treatment satisfaction [median score: 53 RAL + DRV/r vs 55 TDF/FTC + DRV/r (P = 0.001)]. Conclusion: PROs improved after starting antiretroviral therapy, with no statistically significant difference between groups. The lower satisfaction with RAL + DRV/r may be explained by twicedaily administration.
- Published
- 2018
5. Nevirapine, stavudine and lamivudine pharmacokinetics in African children on paediatric fixed-dose combination tablets
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Lʼhomme, Rafaëlla FA, Kabamba, Desiré, Ewings, Fiona M, Mulenga, Veronica, Kankasa, Chipepo, Thomason, Margaret J, Walker, A Sarah, Chintu, Chifumbe, Burger, David M, and Gibb, Diana M
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- 2008
- Full Text
- View/download PDF
6. Survival following HIV infection of a cohort followed up from seroconversion in the UK
- Author
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Ewings, Fiona M, Bhaskaran, Krishnan, McLean, Ken, Hawkins, David, Fisher, Martin, Fidler, Sarah, Gilson, Richard, Nock, Demelza, Brettle, Ray, Johnson, Margaret, Phillips, Andrew, and Porter, Kholoud
- Published
- 2008
- Full Text
- View/download PDF
7. Patient-Reported Outcomes in First-Line Antiretroviral Therapy: Results From NEAT001/ANRS143 Trial Comparing Darunavir/Ritonavir in Combination With Tenofovir/Emtricitabine or Raltegravir
- Author
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George, Elizabeth C. Bucciardini, Raffaella Richert, Laura and Dedes, Nikos Fragola, Vincenzo Nieuwkerk, Pythia Spire, Bruno Volny-Anne, Alain West, Brian Molina, Jean-Michel and Horban, Andrzej Fox, Julie Pozniak, Anton Vella, Stefano and Termote, Monique Raffi, Francois Chene, Genevieve Allavena, Clotilde Autran, Brigitte Antinori, Andrea Arribas, Jose and Babiker, Abdel G. Boffito, Marta Pillay, Deenan Franquet, Xavier Schwarze, Siegfried Grarup, Jesper Fischer, Aurelie and Wallet, Cedrick Diallo, Alpha Saillard, Juliette and Moecklinghoff, Christiane Stellbrink, Hans-Jurgen Van Leeuwen, Remko Gatell, Jose Sandstrom, Eric Flepp, Markus and Babiker, Abdel G. Ewings, Fiona Hudson, Fleur Pearce, Gillian Quercia, Romina Rogatto, Felipe Leavitt, Randi and Nguyen, Bach-Yen Allavena, Clotilde Arnault, Fabien Fischer, Aurelie Paniego, Virginie Schwimmer, Christine Touzeau, Guillaume Wallet, Cedrick Boucherie, Celine Jean, Delphine and Paraina, Felasoa Rouch, Elodie Soussi, Malika Taieb, Audrey Babiker, Abdel G. Ewings, Fiona Dodds, Wendy and Hudson, Fleur Cursley, Adam Hoppe, Anne Kummeling, Ischa and Pacciarini, Filippo Paton, Nick Russell, Charlotte Taylor, Kay Ward, Denise Gey, Daniela Jansson, Per O. Jensen, Karoline Pearson, Mary Nielsen, Birgit Riis Aagaard, Bitten and Eid, Marius Jensen, Birgitte Gram Jakobsen, Marie-Louise and Joensen, Zillah Maria Larsen, Ellen Moseholm Pahl, Christiane and Reilev, Soren Stentoft Lathouwers, Desiree Manting, Corry and Van Leeuwen, Remko Christ, Ilse Diallo, Alpha Mendy, Bienvenu Yves Metro, Annie Saillard, Juliette and Couffin-Cadiergues, Sandrine Palmisiano, Lucia Knellwolf, Anne-Laure Aznar, Esther Barea, Cristina Cotarelo, Manuel and Esteban, Herminia Girbau, Iciar Moyano, Beatriz Ramirez, Miriam Saiz, Carmen Sanchez, Isabel Yllescas, Maria and Binelli, Andrea Colasanti, Valentina Massella, Maurizio and Palmisiano, Lucia Anagnostou, Olga Gioukari, Vicky Touloumi, Giota Schmied, Brigitte Rieger, Armin Vetter, Norbert De Wit, Stephane Florence, Eric Vandekerckhove, Linos Gerstoft, Jan Mathiesen, Lars Katlama, Christine Cabie, Andre and Cheret, Antoine Dupon, Michel Ghosn, Jade Girard, Pierre-Marie Goujard, Cecile Levy, Yves Morlat, J. -M. M. Philippe Neau, Didier Obadia, Martine Perre, Philippe and Piroth, Lionel Reynes, Jacques Tattevin, Pierre Ragnaud, Jean Marie Weiss, Laurence Yazdanpanah, Yazdan Yeni, Patrick and Zucman, David Behrens, Georg Esser, Stefan Fatkenheuer, Gerd Hoffmann, Christian Jessen, Heiko Rockstroh, Jurgen and Schmidt, Reinhold Stephan, Christoph Unger, Stefan Hatzakis, Angelos Daikos, George L. Papadopoulos, Antonios Skoutelis, Athamasios Banhegyi, Denes Mallon, Paddy Mulcahy, Fiona and Antinori, Andrea Andreoni, Massimo Bonora, Stefano Castelli, Francesco D'Arminio, Antonella Monforte Di Perri, Giovanni and Galli, Massimo Lazzarin, Adriano Mazzotta, Francesco Carlo, Torti Vullo, Vincenzo Prins, Jan Richter, Clemens and Verhagen, Dominique Van Eeden, Arne Doroana, Manuela and Antunes, Francisco Maltez, Fernando Sarmento-Castro, Rui and Garcia, Juan Gonzalez Aldeguer, Jose Lopez Clotet, Bonaventura and Domingo, Pere Gatell, Jose M. Knobel, Hernando Marquez, Manuel Pilar, Martin Miralles Portilla, Joaquin Soriano, Vicente Tellez, Maria-Jesus Thalme, Anders Blaxhult, Anders and Gisslen, Magnus Winston, Alan Fox, Julie Gompels, Mark and Herieka, Elbushra Johnson, Margaret Leen, Clifford and Teague, Alastair Williams, Ian Lauriola, Marco Murri, Rita and NEAT 001 ANRS 143 Study Grp TDT TSC TMT
- Abstract
Background: There are few data comparing patient-reported outcomes (PROs) in randomized trials of initial antiretroviral therapy. We present results from a substudy of the NEAT001/ ANRS143 trial. Methods: The randomized trial compared first-line DRV/r 800/100 mg once daily plus RAL 400 mg twice daily and DRV/r plus TDF/ FTC 245/200 mg once daily. Changes in PROs were assessed with 3 questionnaires: EuroQoL 5 domains (EQ-5D), Center for Epidemiologic Studies Depression (CES-D) scale, and HIV Treatment Satisfaction Questionnaire. Major depressive disorder (MDD) was defined as CES-D $ 16. General estimating equations were used to model change over 96 weeks in PROs from baseline. Results: Of the 805 participants, 797 (99%) contributed to the substudy. Baseline PRO data were similar for the 2 randomized groups. Health status improved over time with a mean increase in EQ-5D visual analogue scale (VAS) of 8.0 by W96 [95% confidence interval (CI): 6.5 to 9.4; P, 0.001], and no statistically significant differences between groups (difference of 0.3 on VAS score (95% CI: 21.7 to 2.3); P = 0.7, global P value $ 0.05 for all domains over follow-up). There was no significant difference between groups on CES-D [difference of 20.1 (95% CI: 21.3 to 1.1); P = 0.9], or MDD during follow-up, adjusted for baseline MDD (odds ratio = 0.98, 95% CI: 0.82 to 1.18; P = 0.9). RAL + DRV/r group had lower level of convenience (P = 0.03) and fitted less well into patients’ lifestyle (P = 0.007) than the TDF/FTC + DRV/r regimen, and was associated with lower treatment satisfaction [median score: 53 RAL + DRV/r vs 55 TDF/FTC + DRV/r (P = 0.001)]. Conclusion: PROs improved after starting antiretroviral therapy, with no statistically significant difference between groups. The lower satisfaction with RAL + DRV/r may be explained by twicedaily administration.
- Published
- 2018
8. Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries
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Lodi, Sara, Del Amo, Julia, Moreno, Santiago, Bucher, H. C., Furrer, Hansjakob, Logan, Roger, Sterne, Jonathan, Pérez-Hoyos, Santiago, Jarrín, Inma, Phillips, Andrew, Olson, Ashley, Van Sighem, Ard, Reiss, Peter, Sabin, C., Jose, Sophie, Justice, Amy, Goulet, Joseph, Miró, José M., Ferrer, Elena, Meyer, Laurence, Seng, Rémonie, Vourli, Georgia, Antoniadou, Anastasia, Dabis, Francois, Vandenhede, Mari Anne, Costagliola, Dominique, Abgrall, S., Hernán, Miguel A., Hernan, Miguel, Bansi, L., Hill, T., Dunn, D., Porter, K., Glabay, A., Orkin, C., Thomas, R., Jones, K., Fisher, M., Perry, N., Pullin, A., Churchill, D., Gazzard, B., Nelson, M., Asboe, D., Bulbeck, S., Mandalia, S., Clarke, J., Delpech, V., Anderson, J., Munshi, S., Post, F., Easterbrook, P., Khan, Y., Patel, P., Karim, F., Duffell, S., Gilson, R., Man, S. L., Williams, I., Gompels, M., Dooley, D., Schwenk, A., Ainsworth, J., Johnson, M., Youle, M., Lampe, F., Smith, C., Grabowska, H., Chaloner, C., Ismajani Puradiredja, D., Phillips, A., Walsh, J., Weber, J., Kemble, C., Mackie, N., Winston, A., Leen, C., Wilson, A., Bezemer, D. O., Gras, L. A.J., Kesselring, A. M., Van Sighem, A. I., Zaheri, S., Van Twillert, G., Kortmann, W., Branger, J., Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., Van Der Meer, J. T.M., Wit, F. W.M.N., Godfried, M. H., Reiss, P., Van Der Poll, T., Nellen, F. J.B., Lange, J. M.A., Geerlings, S. E., Van Vugt, M., Pajkrt, D., Bos, J. C., Van Der Valk, M., Grijsen, M. L., Wiersinga, W. J., Brinkman, K., Blok, W. L., Frissen, P. H.J., Schouten, W. E.M., Van Den Berk, G. E.L., Veenstra, J., Lettinga, K. D., Mulder, J. W., Vrouenraets, S. M.E., Lauw, F. N., Van Eeden, A., Verhagen, D. W.M., Van Agtmael, M. A., Perenboom, R. M., Claessen, F. A.P., Bomers, M., Peters, E. J.G., Richter, C., Van Der Berg, J. P., Gisolf, E. H., Schippers, E. F., Van Nieuwkoop, C., Van Elzakker, E. P., Leyten, E. M.S., Gelinck, L. B.S., Pronk, M. J.H., Bravenboer, B., Kootstra, G. J., Delsing, C. E., Sprenger, H. G., Doedens, R., Scholvinck, E. H., Van Assen, S., Bierman, W. F.W., Soetekouw, R., Ten Kate, R. W., Van Vonderen, M. G.A., Van Houte, D. P.F., Kroon, F. P., Van Dissel, J. T., Arend, S. M., De Boer, M. G.J., Jolink, H., Ter Vollaard, H. J.M., Bauer, M. P., Weijer, S., El Moussaoui, R., Lowe, S., Schreij, G., Oude Lashof, A., Posthouwer, D., Koopmans, P. P., Keuter, M., Van Der Ven, A. J.A.M., Ter Hofstede, H. J.M., Dofferhoff, A. S.M., Warris, A., Van Crevel, R., Van Der Ende, M. E., De Vries-Sluijs, T. E.M.S., Schurink, C. A.M., Nouwen, J. L., Nispen Tot Pannerden, M. H., Verbon, A., Rijnders, B. J.A., Van Gorp, E. C.M., Hassing, R. J., Smeulders, A. W.M., Hartwig, N. G., Driessen, G. J.A., Den Hollander, J. G., Pogany, K., Juttmann, J. R., Van Kasteren, M. E.E., Hoepelman, A. I.M., Mudrikova, T., Schneider, M. M.E., Jaspers, C. A.J.J., Ellerbroek, P. M., Oosterheert, J. J., Arends, J. E., Wassenberg, M. W.M., Barth, R. E., Geelen, S. P.M., Wolfs, T. F.W., Bont, L. J., Van Den Berge, M., Stegeman, A., Groeneveld, P. H.P., Alleman, M. A., Bouwhuis, J. W., Barin, F., Burty, C., Duvivier, C., Enel, P., Fredouille-Heripret, L., Gasnault, J., Khuong, M. A., Mahamat, A., Pilorgé, F., Tattevin, P., Salomon, Valérie, Jacquemet, N., Costagliola, D., Grabar, S., Guiguet, M., Lanoy, E., Lièvre, L., Mary-Krause, M., Selinger-Leneman, H., Lacombe, J. M., Potard, V., Bricaire, F., Herson, S., Katlama, C., Simon, A., Desplanque, N., Girard, P. M., Meynard, J. L., Meyohas, M. C., Picard, O., Cadranel, J., Mayaud, C., Pialoux, G., Clauvel, J. P., Decazes, J. M., Gérard, L., Molina, J. M., Diemer, M., Sellier, P., Bentata, M., Honoré, P., Jeantils, V., Tassi, S., Mechali, D., Taverne, B., Bouvet, E., Crickx, B., Ecobichon, J. 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M., Murillo, O., Bolao, F., Peña, C., Cabellos, C., Masó, M., Vila, A., Sala, M., Cervantes, M., Jose Amengual, Ma, Navarro, M., Penelo, E., Barrufet, P., Bejarano, G., Molina, J., Alvaro, M., Mercadal, J., Fernandez, Juanse, Ospina, Jesus E., Muñoz, M. A., Caro-Murillo, A. M., Sobrino, P., Jarrín, I., Gomez Sirvent, J. L., Rodríguez, P., Aleman, M. R., Alonso, M. M., Lopez, A. M., Hernandez, M. I., Soriano, V., Labarga, P., Barreiro, P., Medrano, J., Rivas, P., Herrero, D., Blanco, F., Vispo, M. E., Martín, L., Ramírez, G., De Diego, M., Rubio, R., Pulido, F., Moreno, V., Cepeda, C., Hervás, Rl, Iribarren, J. A., Arrizabalaga, J., Aramburu, M. J., Camino, X., Rodrí-guez-Arrondo, F., Von Wichmann, M. A., Pascual, L., Goenaga, M. A., Gutierrez, F., Masia, M., Ramos, J. M., Padilla, S., Sanchez-Hellín, V., Bernal, E., Escolano, C., Montolio, F., Peral, Y., Berenguer, J., Lopez, J. C., Miralles, P., Cosín, J., Sanchez, M., Gutierrez, I., Ramírez, M., Padilla, B., Vidal, F., Sanjuan, M., Peraire, J., Veloso, S., Vilades, C., Lopez-Dupla, M., Olona, M., Vargas, M., Aldeguer, J. L., Blanes, M., Lacruz, J., Salavert, M., Montero, M., Cuéllar, S., De Los Santos, I., Sanz, J., Oteo, J. A., Blanco, J. R., Ibarra, V., Metola, L., Sanz, M., Pérez-Martínez, L., Sola, J., Uriz, J., Castiello, J., Reparaz, J., Arriaza, M. J., Irigoyen, C., Moreno, S., Antela, A., Casado, J. L., Dronda, F., Moreno, A., Pérez, M. J., López, D., Gutiérrez, C., Hernández, B., Pumares, M., Martí, P., García, L., Page, C., García, F., Hernández, J., Peña, A., Muñoz, L., Parra, J., Viciana, P., Leal, M., López-Cortés, L. F., Trastoy, M., Mata, R., Justice, A. C., Fiellin, D. A., Rimland, D., Jones-Taylor, C., Oursler, K. A., Titanji, R., Brown, S., Garrison, S., Rodriguez-Barradas, M., Masozera, N., Goetz, M., Leaf, D., Simberkoff, M., Blumenthal, D., Leung, J., Butt, A., Hoffman, E., Gibert, C., Peck, R., Mattocks, K., Braithwaite, S., Brandt, C., Bryant, K., Cook, R., Conigliaro, J., Crothers, K., Chang, J., Crystal, S., Day, N., Erdos, J., Freiberg, M., Kozal, M., Gandhi, N., Gaziano, M., Gerschenson, M., Good, B., Gordon, A., Goulet, J. L., Hernán, M. A., Kraemer, K., Lim, J., Maisto, S., Miller, P., Mole, L., O'Connor, P., Papas, R., Robins, J. M., Rinaldo, C., Roberts, M., Samet, J., Tierney, B., Whittle, J., Babiker, A., Brettle, R., Darbyshire, J., Goldberg, D., Hawkins, D., Jaffe, H., Johnson, A., McLean, K., Pillay, D., Cursley, Adam, Ewings, Fiona, Fairbrother, Keith, Louisa Gnatiuc, S. L., Murphy, Brendan, Douglas, G., Kennedy, N., Pritchard, J., Andrady, U., Rajda, N., Maw, R., McKernan, S., Drake, S., Gilleran, G., White, D., Ross, J., Toomer, S., Hewart, R., Wilding, H., Woodward, R., Dean, G., Heald, L., Horner, P., Glover, S., Bansaal, D., Eduards, S., Carne, C., Browing, M., Das, R., Stanley, B., Estreich, S., Magdy, A., O'Mahony, C., Fraser, P., Hayman, B., Jebakumar, S. P.R., Joshi, U., Ralph, S., Wade, A., Mette, R., Lalik, J., Summerfield, H., El-Dalil, A., France, J. A., White, C., Robertson, R., Gordon, S., McMillan, S., Morris, S., Lean, C., Vithayathil, K., McLean, L., Winter, A., Gale, D., Jacobs, S., Tayal, S., Short, L., Green, S., Williams, G., Sivakumar, K., Bhattacharyya, N. D., Monteiro, E., Minton, J., Dhar, J., Nye, F., De Souza, C. B., Isaksen, A., McDonald, L., Franca, A., William, L., Jendrulek, I., Peters, B., Shaunak, S., El-Gadi, S., Easterbrook, P. J., Mazhude, C., Johnstone, R., Fakoya, A., McHale, J., Waters, A., Kegg, S., Mitchell, S., Byrne, P., Rice, P., Fidler, S., Mullaney, S. A., McCormack, S., David, D., Melville, R., Phillip, K., Balachandran, T., Mabey-Puttock, S., Sukthankar, A., Murphy, C., Wilkins, E., Ahmad, S., Haynes, J., Evans, E., Ong, E., Grey, R., Meaden, J., Bignell, C., Loay, D., Peacock, K., Girgis, M. R., Morgan, B., Palfreeman, A., Wilcox, J., Tobin, J., Tucker, L., Saeed, A. M., Chen, F., Deheragada, A., Williams, O., Lacey, H., Herman, S., Kinghorn, D., Devendra, V. S., Wither, J., Dawson, S., Rowen, D., Harvey, J., Bridgwood, A., Singh, G., Chauhan, M., Kellock, D., Young, S., Dannino, S., Kathir, Y., Rooney, G., Currie, J., FitzGerald, M., Devendra, S., Keane, F., Booth, G., Green, T., Arumainayyagam, J., Chandramani, S., Rajamanoharan, S., Robinson, T., Curless, E., Gokhale, R., Tariq, A., Luzzi, G., Fairley, I., Wallis, F., Smit, E., Ward, F., Loze, B., Morlat, P., Bonarek, M., Bonnet, F., Nouts, C., Louis, I., Reliquet, V., Sauser, F., Biron, C., Mounoury, O., Hue, H., Brosseau, D., Ghosn, J., Rannou, M. T., Bergmann, J. F., Badsi, E., Rami, A., Parrinello, M., Samanon-Bollens, D., Campa, P., Tourneur, M., Desplanques, N., Jeanblanc, F., Chiarello, P., Makhloufi, D., Blanc, A. P., Allègre, T., Baillat, V., Lemoing, V., Merle De Boever, C., Tramoni, C., Sobesky, G., Abel, S., Beaujolais, V., Slama, L., Chakvetadze, C., Berrebi, V., Fournier, I., Gerbe, J., Koffi, K., Augustin-Normand, C., Miailhes, P., Thoirain, V., Brochier, C., Souala, F., Ratajczak, M., Beytoux, J., Jacomet, C., Rouveix, E., Morelon, S., Olivier, C., Lortholary, O., Dupont, B., Maignan, A., Ragnaud, J. M., Raymond, I., Leport, C., Jadand, C., Jestin, C., Longuet, P., Boucherit, S., Sereni, D., Lascoux, C., Prevoteau, F., Sobel, A., Levy, Y., Lelievre, J. D., Lascaux, A. S., Dominguez, S., Dumont, C., Aumâitre, H., Delmas, B., Saada, M., Medus, M., Guillevin, L., Tahi, T., Yazdanpanah, Y., Pavel, S., Marien, M. C., Drenou, B., Beck, C., Benomar, M., Tubiana, R., Ait Mohand, H., Chermak, A., Ben Abdallah, S., Touam, F., Drobacheff, C., Folzer, A., Obadia, M., Prudhomme, L., Bonnet, E., Balzarin, F., Pichard, E., Chennebault, J. M., Fialaire, P., Loison, J., Galanaud, P., Boué, F., Bornarel, D., Six, M., Ferret, P., Batisse, D., Gonzales-Canali, G., Devidas, A., Chevojon, P., Turpault, I., Lafeuillade, A., Cheret, A., Philip, G., Morel, P., Timsit, J., Amirat, N., Brancion, C., Cabane, J., Tredup, J., Stein, A., Ravault, I., Chavanet, C., Buisson, M., Treuvetot, S., Nau, P., Bastides, F., Boyer, L., Wassoumbou, S., Oksenhendeler, E., Bernard, L., Domart, Y., Merrien, D., Greder Belan, A., Gayraud, M., Bodard, L., Meudec, A., Beuscart, C., Daniel, C., Pape, E., Vinceneux, P., Simonpoli, A. M., Zeng, A., Fournier, L., Fuzibet, J. G., Sohn, C., Rosenthal, E., Quaranta, M., Chaillou, S., Sabah, M., Audhuy, B., Schieber, A., Moreau, P., Niault, M., Vaillant, O., Huchon, G., Compagnucci, A., De Lacroix Szmania, I., Richier, L., Lamaury, I., Saint-Dizier, F., Garipuy, D., Drogoul, M. P., Fabre, G., Lambert De Cursay, G., Abraham, B., Perino, C., Lagarde, P., David, F., Roche-Sicot, J., Saraux, J. L., Leprêtre, A., Fampin, B., Uludag, A., Morin, A. S., Bletry, O., Zucman, D., Regnier, A., Girard, J. J., Quinsat, D. T., Heripret, L., Grihon, F., Houlbert, D., Ruel, M., Chemlal, K., Debab, Y., Tremollieres, F., Perronne, V., Slama, B., Perré, P., Miodovski, C., Guermonprez, G., Dulioust, A., Boudon, P., Malbec, D., Patey, O., Semaille, C., Deville, J., Remy, G., Béguinot, I., Chambrin, V., Pignon, C., Estocq, G. A., Levy, A., Duracinsky, M., Le Bras, P., Ngussan, M. S., Peretti, D., Medintzeff, N., Lambert, T., Segeral, O., Lezeau, P., Laurian, Y., Piketty, C., Karmochkine, M., Eliaszewitch, M., Jayle, D., Kazatchkine, M., Colasante, U., Duval, X., Nouaouia, W., Vilde, J. L., Bollens, D., Binet, D., Diallo, B., Fonquernie, L., Lagneau, J. L., Launay, O., Pietrie, M. P., Sicard, D., Stieltjes, N., Michot, J., Bourdillon, F., Obenga, G., Escaut, L., Bolliot, C., Schneider, L., Iguertsira, M., Tomei, C., Dhiver, C., Tissot Dupont, H., Vallon, A., Gallais, J., Gallais, H., Durant, J., Mondain, V., Perbost, I., Cassuto, J. P., Karsenti, J. M., Venti, H., Ceppi, C., Krivitsky, J. A., Bouchaud, O., Honore, P., Delgado, J., Rouzioux, C., Burgard, M., Boufassa, L., Peynet, J., Pérez-Hoyos, S., Del Amo, J., Alvarez, D., Monge, S., Muga, R., Sanvisens, A., Tor, J., Rivas, I., Vallecillo, G., Del Romero, J., Raposo, P., Rodríguez, C., Vera, M., Hurtado, I., Belda, J., Fernandez, E., Alastrue, I., Santos, C., Tasa, T., Juan, A., Trullen, J., Garcia De Olalla, P., Cayla, J., Masdeu, E., Knobel, H., Mirò, J. M., Sambeat, M. A., Guerrero, R., Rivera, E., Marco, A., Quintana, M., Gonzalez, C., Castilla, J., Guevara, M., De Mendoza, C., Zahonero, N., Ortíz, M., Paraskevis, D., Touloumi, G., Pantazis, N., Bakoyannis, G., Gioukari, V., Antoniadou, A., Papadopoulos, A., Petrikkos, G., Daikos, G., Psichogiou, M., Gargalianos-Kakolyris, P., Xylomenos, G., Katsarou, O., Kouramba, A., Ioannidou, P., Kordossis, T., Kontos, A., Lazanas, M., Chini, M., Tsogas, N., Panos, G., Paparizos, V., Leuow, K., Kourkounti, S., Sambatakou, H., Mariolis, I., Skoutelis, A., Papastamopoulos, V., Baraboutis, I., Internal medicine, APH - Aging & Later Life, Pediatric surgery, CCA - Innovative therapy, ICaR - Circulation and metabolism, ICaR - Ischemia and repair, Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, Landsteiner Laboratory, AII - Amsterdam institute for Infection and Immunity, Infectious diseases, Global Health, Center of Experimental and Molecular Medicine, APH - Amsterdam Public Health, AII - Inflammatory diseases, and ARD - Amsterdam Reproduction and Development
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Opportunistic infection ,AIDS-Related Opportunistic Infections ,Immunology ,Population ,Retinitis ,HIV Infections ,Article ,17 Psychology And Cognitive Sciences ,Young Adult ,Immune reconstitution inflammatory syndrome ,Antiretroviral Therapy, Highly Active ,Neoplasms ,Virology ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,education ,Inverse probability weighting ,Aged ,education.field_of_study ,business.industry ,Developed Countries ,Incidence ,Progressive multifocal leukoencephalopathy ,Hazard ratio ,HIV ,virus diseases ,11 Medical And Health Sciences ,Middle Aged ,06 Biological Sciences ,medicine.disease ,United States ,Europe ,Infectious Diseases ,Anti-Retroviral Agents ,Unmasking ,Female ,Cytomegalovirus retinitis ,business - Abstract
Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis.Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting.Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis.Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries.
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- 2014
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9. Short-course antiretroviral therapy in primary HIV infection
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SPARTAC Trial Investigators, Fidler, Sarah, Porter, Kholoud, Ewings, Fiona, Frater, John, Ramjee, Gita, Cooper, David, Rees, Helen, Fisher, Martin, Schechter, Mauro, Kaleebu, Pontiano, Tambussi, Giuseppe, Kinloch, Sabine, Miro, Jose M, Kelleher, Anthony, McClure, Myra, Kaye, Steve, Gabriel, Michelle, Phillips, Rodney, Weber, Jonathan, and Babiker, Abdel
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BACKGROUND: Short-course antiretroviral therapy (ART) in primary human immunodeficiency virus (HIV) infection may delay disease progression but has not been adequately evaluated. METHODS: We randomly assigned adults with primary HIV infection to ART for 48 weeks, ART for 12 weeks, or no ART (standard of care), with treatment initiated within 6 months after seroconversion. The primary end point was a CD4+ count of less than 350 cells per cubic millimeter or long-term ART initiation. RESULTS: A total of 366 participants (60% men) underwent randomization to 48-week ART (123 participants), 12-week ART (120), or standard care (123), with an average follow-up of 4.2 years. The primary end point was reached in 50% of the 48-week ART group, as compared with 61% in each of the 12-week ART and standard-care groups. The average hazard ratio was 0.63 (95% confidence interval [CI], 0.45 to 0.90; P=0.01) for 48-week ART as compared with standard care and was 0.93 (95% CI, 0.67 to 1.29; P=0.67) for 12-week ART as compared with standard care. The proportion of participants who had a CD4+ count of less than 350 cells per cubic millimeter was 28% in the 48-week ART group, 40% in the 12-week group, and 40% in the standard-care group. Corresponding values for long-term ART initiation were 22%, 21%, and 22%. The median time to the primary end point was 65 weeks (95% CI, 17 to 114) longer with 48-week ART than with standard care. Post hoc analysis identified a trend toward a greater interval between ART initiation and the primary end point the closer that ART was initiated to estimated seroconversion (P=0.09), and 48-week ART conferred a reduction in the HIV RNA level of 0.44 log(10) copies per milliliter (95% CI, 0.25 to 0.64) 36 weeks after the completion of short-course therapy. There were no significant between-group differences in the incidence of the acquired immunodeficiency syndrome, death, or serious adverse events. CONCLUSIONS: A 48-week course of ART in patients with primary HIV infection delayed disease progression, although not significantly longer than the duration of the treatment. There was no evidence of adverse effects of ART interruption on the clinical outcome. (Funded by the Wellcome Trust; SPARTAC Controlled-Trials.com number, ISRCTN76742797, and EudraCT number, 2004-000446-20.).
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- 2013
10. Oesophageal varices, schistosomiasis, and mortality among patients admitted with haematemesis in Mwanza, Tanzania: a prospective cohort study
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Chofle, Awilly A, primary, Jaka, Hyasinta, additional, Koy, Mheta, additional, Smart, Luke R, additional, Kabangila, Rodrick, additional, Ewings, Fiona M, additional, Mazigo, Humphrey D, additional, Johnson, Warren D, additional, Fitzgerald, Daniel W, additional, Peck, Robert N, additional, and Downs, Jennifer A, additional
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- 2014
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11. HIV-1-specific CD4 + responses in primary HIV-1 infection predict disease progression
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Frater, John, primary, Ewings, Fiona, additional, Hurst, Jacob, additional, Brown, Helen, additional, Robinson, Nicola, additional, Fidler, Sarah, additional, Babiker, Abdel, additional, Weber, Jonathan, additional, Porter, Kholoud, additional, and Phillips, Rodney E., additional
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- 2014
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12. Deciphering the Complex Distribution of Human Immunodeficiency Virus Type 1 Subtypes among Different Cohorts in Northern Tanzania
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Njai, Harr F., primary, Ewings, Fiona M., additional, Lyimo, Eric, additional, Foulongne, Vincent, additional, Ngerageza, Dhamira, additional, Mongi, Aika, additional, Ssemwanga, Deogratius, additional, Andreasen, Aura, additional, Nyombi, Balthazar, additional, Ao, Tony, additional, Michael, Denna, additional, Urassa, Mark, additional, Todd, Jim, additional, Zaba, Basia, additional, Changalucha, John, additional, Hayes, Richard, additional, and Kapiga, Saidi H., additional
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- 2013
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13. The Epidemiology of HIV and HSV-2 Infections among Women Participating in Microbicide and Vaccine Feasibility Studies in Northern Tanzania
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Kapiga, Saidi H., primary, Ewings, Fiona M., additional, Ao, Tony, additional, Chilongani, Joseph, additional, Mongi, Aika, additional, Baisley, Kathy, additional, Francis, Suzanna, additional, Andreasen, Aura, additional, Hashim, Ramadhan, additional, Watson-Jones, Deborah, additional, Changalucha, John, additional, and Hayes, Richard, additional
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- 2013
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14. Limited Sampling Models to Predict the Pharmacokinetics of Nevirapine, Stavudine, and Lamivudine in HIV-Infected Children Treated With Pediatric Fixed-Dose Combination Tablets
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Burger, David, primary, Ewings, Fiona, additional, Kabamba, Desiré, additional, L'homme, Rafaëlla, additional, Mulenga, Veronica, additional, Kankasa, Chipepo, additional, Thomason, Margaret, additional, Gibb, Diana M, additional, Chintu, Chifumbe, additional, and Walker, A Sarah, additional
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- 2010
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15. Nevirapine, stavudine and lamivudine pharmacokinetics in African children on paediatric fixed-dose combination tablets
- Author
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L'homme, Rafaëlla FA, primary, Kabamba, Desiré, additional, Ewings, Fiona M, additional, Mulenga, Veronica, additional, Kankasa, Chipepo, additional, Thomason, Margaret J, additional, Walker, A Sarah, additional, Chintu, Chifumbe, additional, Burger, David M, additional, and Gibb, Diana M, additional
- Published
- 2008
- Full Text
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16. Nevirapine Concentrations in HIV-Infected Children treated with Divided Fixed-Dose Combination Antiretroviral Tablets in Malawi and Zambia
- Author
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Ellis, Jane C, primary, L'homme, Rafaëlla FA, additional, Ewings, Fiona M, additional, Mulenga, Veronica, additional, Bell, Frank, additional, Chileshe, Regina, additional, Molyneux, Elizabeth, additional, Abernethy, Julia, additional, Van Oosterhout, Joep JG, additional, Chintu, Chifumbe, additional, Walker, A Sarah, additional, Gibb, Diana M, additional, and Burger, David M, additional
- Published
- 2007
- Full Text
- View/download PDF
17. Plasma HIV Viral Rebound following Protocol-Indicated Cessation of ART Commenced in Primary and Chronic HIV Infection.
- Author
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Hamlyn, Elizabeth, Ewings, Fiona M., Porter, Kholoud, Cooper, David A., Tambussi, Giuseppe, Schechter, Mauro, Pedersen, Court, Okulicz, Jason F., McClure, Myra, Babiker, Abdel, Weber, Jonathan, Fidler, Sarah, and Verhasselt, Bruno
- Subjects
- *
HIV , *CELL populations , *CD4 antigen , *HTLV , *HIV infections , *DISEASES - Abstract
Objectives: The magnitude of HIV viral rebound following ART cessation has consequences for clinical outcome and onward transmission. We compared plasma viral load (pVL) rebound after stopping ART initiated in primary (PHI) and chronic HIV infection (CHI). Design: Two populations with protocol-indicated ART cessation from SPARTAC (PHI, n = 182) and SMART (CHI, n = 1450) trials. Methods: Time for pVL to reach pre-ART levels after stopping ART was assessed in PHI using survival analysis. Differences in pVL between PHI and CHI populations 4 weeks after stopping ART were examined using linear and logistic regression. Differences in pVL slopes up to 48 weeks were examined using linear mixed models and viral burden was estimated through a time-averaged area-under-pVL curve. CHI participants were categorised by nadir CD4 at ART stop. Results: Of 171 PHI participants, 71 (41.5%) rebounded to pre-ART pVL levels, at a median of 50 (95% CI 48-51) weeks after stopping ART. Four weeks after stopping treatment, although the proportion with pVL≥400 copies/ml was similar (78% PHI versus 79% CHI), levels were 0.45 (95% CI 0.26-0.64) log10 copies/ml lower for PHI versus CHI, and remained lower up to 48 weeks. Lower CD4 nadir in CHI was associated with higher pVL after ART stop. Rebound for CHI participants with CD4 nadir >500 cells/mm³ was comparable to that experienced by PHI participants. Conclusions: Stopping ART initiated in PHI and CHI was associated with viral rebound to levels conferring increased transmission risk, although the level of rebound was significantly lower and sustained in PHI compared to CHI. [ABSTRACT FROM AUTHOR]
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- 2012
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18. HIV-1-specific CD4responses in primary HIV-1 infection predict disease progression
- Author
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Frater, John, Ewings, Fiona, Hurst, Jacob, Brown, Helen, Robinson, Nicola, Fidler, Sarah, Babiker, Abdel, Weber, Jonathan, Porter, Kholoud, and Phillips, Rodney E.
- Abstract
Immune factors determining clinical progression following HIV-1 infection remain unclear. The SPARTAC trial randomized 366 participants in primary HIV infection (PHI) to different short-course therapies. The aim of this study was to investigate how early immune responses in PHI impacted clinical progression in SPARTAC.
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- 2014
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19. Short-course antiretroviral therapy in primary HIV infection.
- Author
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Fidler S, Porter K, Ewings F, Frater J, Ramjee G, Cooper D, Rees H, Fisher M, Schechter M, Kaleebu P, Tambussi G, Kinloch S, Miro JM, Kelleher A, McClure M, Kaye S, Gabriel M, Phillips R, Weber J, and Babiker A
- Subjects
- Adult, Anti-Retroviral Agents adverse effects, Anti-Retroviral Agents therapeutic use, CD4 Lymphocyte Count, Disease Progression, Drug Administration Schedule, Female, Follow-Up Studies, HIV genetics, HIV isolation & purification, HIV Infections immunology, Humans, Male, Middle Aged, RNA, Viral blood, Young Adult, Anti-Retroviral Agents administration & dosage, HIV Infections drug therapy
- Abstract
Background: Short-course antiretroviral therapy (ART) in primary human immunodeficiency virus (HIV) infection may delay disease progression but has not been adequately evaluated., Methods: We randomly assigned adults with primary HIV infection to ART for 48 weeks, ART for 12 weeks, or no ART (standard of care), with treatment initiated within 6 months after seroconversion. The primary end point was a CD4+ count of less than 350 cells per cubic millimeter or long-term ART initiation., Results: A total of 366 participants (60% men) underwent randomization to 48-week ART (123 participants), 12-week ART (120), or standard care (123), with an average follow-up of 4.2 years. The primary end point was reached in 50% of the 48-week ART group, as compared with 61% in each of the 12-week ART and standard-care groups. The average hazard ratio was 0.63 (95% confidence interval [CI], 0.45 to 0.90; P=0.01) for 48-week ART as compared with standard care and was 0.93 (95% CI, 0.67 to 1.29; P=0.67) for 12-week ART as compared with standard care. The proportion of participants who had a CD4+ count of less than 350 cells per cubic millimeter was 28% in the 48-week ART group, 40% in the 12-week group, and 40% in the standard-care group. Corresponding values for long-term ART initiation were 22%, 21%, and 22%. The median time to the primary end point was 65 weeks (95% CI, 17 to 114) longer with 48-week ART than with standard care. Post hoc analysis identified a trend toward a greater interval between ART initiation and the primary end point the closer that ART was initiated to estimated seroconversion (P=0.09), and 48-week ART conferred a reduction in the HIV RNA level of 0.44 log(10) copies per milliliter (95% CI, 0.25 to 0.64) 36 weeks after the completion of short-course therapy. There were no significant between-group differences in the incidence of the acquired immunodeficiency syndrome, death, or serious adverse events., Conclusions: A 48-week course of ART in patients with primary HIV infection delayed disease progression, although not significantly longer than the duration of the treatment. There was no evidence of adverse effects of ART interruption on the clinical outcome. (Funded by the Wellcome Trust; SPARTAC Controlled-Trials.com number, ISRCTN76742797, and EudraCT number, 2004-000446-20.).
- Published
- 2013
- Full Text
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