1. Transcranial, noninvasive evaluation of the potential misery perfusion during hyperventilation therapy of traumatic brain injury patients
- Author
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Universitat Politècnica de Catalunya. Doctorat en Fotònica, Tagliabue, Susanna, Maruccia, Federica, Fischer, Jonas, Riveiro Vilaboa, Marilyn, Rey Pérez, Anna, Expósito, Lourdes, Lindner, Claus, Báguena Martínez, Marcelino, Durduran, Turgut, Poca, Maria, Serra, Isabel, Kacprzak, Michal, Universitat Politècnica de Catalunya. Doctorat en Fotònica, Tagliabue, Susanna, Maruccia, Federica, Fischer, Jonas, Riveiro Vilaboa, Marilyn, Rey Pérez, Anna, Expósito, Lourdes, Lindner, Claus, Báguena Martínez, Marcelino, Durduran, Turgut, Poca, Maria, Serra, Isabel, and Kacprzak, Michal
- Abstract
Hyperventilation (HV) therapy uses vasoconstriction to reduce intracranial pressure (ICP) by reducing cerebral blood volume. However, as HV also lowers cerebral blood flow (CBF), it may provoke misery perfusion (MP) where the decrease in CBF is coupled with increased oxygen extraction fraction (OEF). MP may rapidly lead to the exhaustion of brain energy metabolites, making it vulnerable to ischemia. MP is difficult to detect at the bedside, which is where transcranial hybrid, near-infrared spectroscopies are promising since they noninvasively measure OEF and CBF., Peer Reviewed, Postprint (author's final draft)
- Published
- 2023