1. [Value of sequential scintrigraphy and clearance determination following normo- and hypothermic renal ischemia]
- Author
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R, Rothe, F, Esenberger, K J, Pfeifer, C, Chaussy, U, Klein, and H G, Heinze
- Subjects
Postoperative Care ,Radioisotopes ,Time Factors ,Metabolic Clearance Rate ,Urography ,Hypothermia ,Kidney ,Perfusion ,Kidney Calculi ,Dogs ,Hypothermia, Induced ,Ischemia ,Regional Blood Flow ,Preoperative Care ,Animals ,Humans ,Female ,Iodohippuric Acid ,Ytterbium ,Radionuclide Imaging ,Radioisotope Renography ,Edetic Acid - Abstract
Using quantitative sequential camera scintigraphy and simultaneous separated clearance determinations with 131-I-Hippuran and 169-Yb-EDTA renal function was measured applying a new surgical method which permits in-situ kidney perfusion and cooling in animals and patients. While mongrel dogs of 15 kg average weight (control group of N = 5) showed after 1 hour of normothermic ischaemia a postoperative delay of intrarenal transport of 131-I-Hippuran with reduction of 131-I-Hippuran and 169Yb-EDTA clearances, renal function returned to normal on the first postoperative day after 1-hour (N = 5) and 2-hour (N = 5) hypothermic ischaemia. In patients (N = 9) with hypothermic in-situ perfusion of between 40 and 92 min duration a transient postoperative delay of intrarenal 131-I-Hippuran transport and a reduction of the 131I-Hippuran clearance was observed which returned to almost normal 1 1/2 to 3 months after surgery. The results and the significance of the method discussed and are compared with clinical findings and with radiological and laboratory renal function studies.
- Published
- 1975