Author: "F., Palma" - Searchworks@Jio Institute Digital Library Search Results

791 results on '"F., Palma"'

1. Factors Associated with Voluntary Discharge in a Hospital Detoxification Unit: An Observational and Descriptive Analysis

Author: P. Gamboa Lozada, G. Ortega Hernández, R. F. Palma Álvarez, A. Ríos Landeo, J. A. Ramos Quiroga, and L. Grau López
Subjects: Psychiatry, RC435-571
Abstract: Introduction Adherence to treatment for addictive disorders remains a clinical challenge. Despite detoxification admissions being scheduled and initiated voluntarily by the patient, several factors may contribute to treatment discontinuation.1 Understanding these factors will enable the development of specific interventions for a more effective approach.2 Objectives To identify and analyze the relationship between specific clinical factors and voluntary treatment discontinuation. Methods An observational and descriptive study was conducted using a retrospective database of 1146 patients admitted to the “Hospital Universitari Vall d’Hebron” Detoxification Unit between June 2008 and December 2019. Bivariate analysis was conducted to identify individual associations between clinical factors and voluntary discharge. Subsequently, a multivariate analysis was performed to assess the combined influence of these factors while controlling for potential confounding variables. Results A total of 135 patients (11.8%) requested voluntary discharge. Significant differences were found between the voluntary discharge and non-voluntary discharge groups in patients with dual diagnosis (91.1% vs 80.9%, p
Published: 2024
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2. A preliminary analysis of clinical characteristics of patient with alcohol use disorder and suicidal ideation

Author: R. F. Palma-Alvarez, A. Rios-Landeo, G. Ortega-Hernandez, E. Ros-Cucurull, C. Daigre, M. Perea-Ortueta, L. Grau-Lopez, and J. A. Ramos-Quiroga
Subjects: Psychiatry, RC435-571
Abstract: Introduction Suicidal behaviors are frequently observed among patients with substance use disorder, including suicidal ideation (SI) (1). Alcohol use disorder (AUD) is one of the most prevalent addictions and may be related to suicidal behaviors (2,3). However, the association between AUD and SI requires a deeper analysis which includes several clinical features observed among AUD patients. Objectives To analyze the clinical characteristics and features associated with lifetime SI among patients who had AUD. Methods This is a cross-sectional study performed in an outpatient center for addiction treatment in patients seeking treatment who met the criteria for AUD between 01/01/2010 and 12/31/2021. Patients were evaluated with an ad-hoc questionnaire and the European addiction severity index (EuropASI). SI was evaluated by using the item for SI in EuropASI. Results From a potential sample of n=3729 patients, only n=1082 (73.8% males; mean age 42.82±12.51) met inclusion criteria and had data for the current analysis. Lifetime SI was present in 50.9% of the AUD patients. Several clinical features were related to SI, including: sex differences, any type of lifetime abuse, polyconsumption, benzodiazepine use disorder, any psychiatric diagnosis aside of SUD, and higher addiction severity according to the EuropASI (See table) Image: Conclusions SI among AUD patients is related to several clinical features which indicate a higher addiction severity, more polyconsumption, and a higher prevalence of psychiatric comorbidities. These findings may contribute to the understanding of suicidal behaviors in AUD patients but it is required further investigations, including longitudinal studies. REFERENCES 1. Rodríguez-Cintas L, et al. Factors associated with lifetime suicidal ideation and suicide attempts in outpatients with substance use disorders. Psychiatry Res. 2018;262:440-445. doi:10.1016/j.psychres.2017.09.02 2. MacKillop J, et al. Hazardous drinking and alcohol use disorders. Nat Rev Dis Primers. 2022;8(1):80. doi:10.1038/s41572-022-00406-1 3. Darvishi N, et al. Alcohol-related risk of suicidal ideation, suicide attempt, and completed suicide: a meta-analysis [published correction appears in PLoS One. 2020;15(10):e0241874]. PLoS One. 2015;10(5):e0126870. doi:10.1371/journal.pone.0126870 Disclosure of Interest R. Palma-Alvarez Speakers bureau of: RFPA has received speaker honorariums from Angelini, Cassen Recordati, Exeltis, Lundbeck, MSD, Rubió, Servier, and Takeda., A. Rios-Landeo: None Declared, G. Ortega-Hernandez Speakers bureau of: GOH has received speaker honorariums from Rubió., E. Ros-Cucurull Speakers bureau of: ERC has received speaker honorariums from Janssen-Cilag, Lundbeck, Otsuka, Pfizer, Lilly, Servier, Rovi, Juste., C. Daigre: None Declared, M. Perea-Ortueta: None Declared, L. Grau-Lopez Speakers bureau of: LGL has received fees to give talks for Janssen-Cilag, Lundbeck, Servier, Otsuka, and Pfizer., J. Ramos-Quiroga Speakers bureau of: JARQ has been on the speakers’ bureau and/or acted as consultant for Janssen-Cilag, Novartis, Shire, Takeda, Bial, Shionogi, Sincrolab, Novartis, BMS, Medice, Rubió, Uriach and Raffo.
Published: 2024
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3. Psychiatric brain gain in Switzerland. Competency-based onboarding.

Author: D. Gurrea Salas and R. F. Palma Álvarez
Subjects: Psychiatry, RC435-571
Abstract: Introduction In the last 30 years, Switzerland has been established as a destination country for psychiatric trainees. The needed competences for the work as a trainee deviate regarding colleagues from foreign countries though, hindering a viable solid development professional without specific on-boarding program. A similar approach to the figure of tutor anchored in the Spanish postgraduate medical training is still missing in the Swiss medical System. Hereby we performed a survey in the new colleagues who are part from the medical team in an observer status before beginning with the responsibilities as a trainee. Objectives Recognizing competences and needs of the onboarding in current trainees that are still allocating because of the work conditions as stated in the following paper, (Bischof et al. Swiss Arch Neurol Psychiatr Psychother. 2021;172:w03198) Methods Survey with open questions collecting needs and competences expected to fulfil in Switzerland were distributed in 5 different medical colleagues in an observer status between August 2022 and September 2023. Results Response rate was 62,5 %. Main reasons for the migration were considering better perspectives in education and professional development in the goal country, coming push factors as the current work situation in the original country to the fore. Support regarding the local language and an overview of the interprofessional communication were outlined as the advantage of the internship prior to the duties as a psychiatric trainee. Conclusions An structured on-boarding program is a demand for the newcomers - majority of trainees from foreign countries - to step in better in the Swiss health system. Elements of the Spanish trainee system could be adapted for a suitable allocation and integration process in the goal country. Disclosure of Interest None Declared
Published: 2024
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4. Clinical features and factors related to suicidal ideation in adult patients with benzodiazepine use disorder

Author: P. Querol Clares, G. Ortega Fernandez, R.-F. Palma Alvarez, C. Daigre, M. Alijotas Capdevila, J.-A. Ramos Quiroga, and L. Grau Lopez
Subjects: Psychiatry, RC435-571
Abstract: Introduction Benzodiazepine use disorder (BUD) has been associated with the presence of suicidal ideation (SI) in general population. It seems there is an overall increase in the risk of attempting suicide due to the increase of impulsivity, rebound and withdrawal of those who use benzodiazepines(1). However, this association has been scarcely studied. Objectives To explore the prevalence, clinical features and factors related to lifetime SI in adults with BUD. Methods A cross-sectional study was conducted in an outpatient center for addiction treatment between 01/01/2010 and 12/31/2021. Adult patients who met criteria for active BUD were included. Patients with language barriers, cognitive impairments and those who were participating in any clinical trial were excluded. All patients were evaluated with an ad-hoc questionnaire, EuropASI (European Addiction Severity Index), BDI (Beck Depression Inventory) and HRQoL SF-36 (Health-related quality of life according to SF-36). Univariate and bivariate analyses were performed comparing BUD patients with or without SI. Results 554 patients were included (65.2% males; M age 42.6±12.6 years). SI was reported in 57.2% of the patients. Regarding the sociodemographic variables, any type of lifetime abuse was correlated with SI (67.8%, 73.5% and 77.8% of the patients with emotional, physical and sexual abuse respectively). Considering the different psychiatric features studied, having any psychiatric diagnosis increased SI up to 64%. Depressive and cluster B personality disorders were the ones with a higher presence of SI (67.1% and 68.1% respectively). Anxiety and cluster A personality disorders had also higher proportions of SI (56.1% and 58,7% respectively). Regarding the different assessment instruments used, a higher punctuation on BDI score was seen in the group of patients with SI (23.73±12.86). The scores also showed a worse perception of the mental quality of life of those people with SI, measured by HRQoL (13.76 and 36.82±31.93 in patients with SI and no SI respectively). Considering the EuropASI, there was an increased proportion of SI in those patients with a worse familiar situation (0.44±0.30), a higher alcohol consumption (0.26±0.28) and a worse psychological condition (0.48±0.24). Conclusions The prevalence of SI in patients with BUD is significative and is related to several clinical factors. Those factors should be taken into account in daily clinical practice, research, and any health policies on suicide. Further research should be developed. 1. Dodds, T.J. ‘Prescribed benzodiazepines and suicide risk’, The Primary Care Companion For CNS Disorders 2017; 19(2). Disclosure of Interest None Declared
Published: 2024
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5. Discovery of 118 New Ultracool Dwarf Candidates Using Machine-learning Techniques

Author: Hunter Brooks, Dan Caselden, J. Davy Kirkpatrick, Yadukrishna Raghu, Charles A. Elachi, Jake Grigorian, Asa Trek, Andrew Washburn, Hiro Higashimura, Aaron M. Meisner, Adam C. Schneider, Jacqueline K. Faherty, Federico Marocco, Christopher R. Gelino, Jonathan Gagné, Thomas P. Bickle, Shih-Yun Tang, Austin Rothermich, Adam J. Burgasser, Marc J. Kuchner, Paul Beaulieu, John Bell, Guillaume Colin, Giovanni Colombo, Alexandru Dereveanco, Deiby Pozo Flores, Konstantin Glebov, Leopold Gramaize, Les Hamlet, Ken Hinckley, Martin Kabatnik, Frank Kiwy, David W. Martin, Raúl F. Palma Méndez, Billy Pendrill, Lizzeth Ruiz, John Sanchez, Arttu Sainio, Jörg Schümann, Manfred Schonau, Christopher Tanner, Nikolaj Stevnbak, Andres Stenner, Melina Thévenot, Vinod Thakur, Nikita V. Voloshin, Zbigniew Wȩdracki, and The Backyard Worlds: Planet 9 Collaboration
Subjects: Brown dwarfs, Subdwarf stars, Low mass stars, Astronomy, QB1-991
Abstract: We present the discovery of 118 new ultracool dwarf candidates, discovered using a new machine-learning tool, named SMDET , applied to time-series images from the Wide-field Infrared Survey Explorer. We gathered photometric and astrometric data to estimate each candidate’s spectral type, distance, and tangential velocity. This sample has a photometrically estimated spectral class distribution of 28 M dwarfs, 64 L dwarfs, and 18 T dwarfs. We also identify a T-subdwarf candidate, two extreme T-subdwarf candidates, and two candidate young ultracool dwarfs. Five objects did not have enough photometric data for any estimations to be made. To validate our estimated spectral types, spectra were collected for two objects, yielding confirmed spectral types of T5 (estimated T5) and T3 (estimated T4). Demonstrating the effectiveness of machine-learning tools as a new large-scale discovery technique.
Published: 2024
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6. Multispacecraft Observations of Protons and Helium Nuclei in Some Solar Energetic Particle Events toward the Maximum of Cycle 25

Author: S. Bartocci, R. Battiston, S. Benella, S. Beolè, W. J. Burger, P. Cipollone, A. Contin, M. Cristoforetti, C. De Donato, C. De Santis, A. Di Luca, F. M. Follega, G. Gebbia, R. Iuppa, M. Laurenza, A. Lega, M. Lolli, M. Martucci, G. Masciantonio, M. Mergè, M. Mese, C. Neubuser, R. Nicolaidis, F. Nozzoli, A. Oliva, G. Osteria, F. Palma, B. Panico, F. Perfetto, A. Perinelli, P. Picozza, E. Ricci, M. Ricci, S. B. Ricciarini, Z. Sahnoun, U. Savino, V. Scotti, M. Sorbara, A. Sotgiu, R. Sparvoli, P. Ubertini, V. Vilona, S. Zoffoli, and P. Zuccon
Subjects: Active solar corona, Particle physics, Astrophysics, QB460-466
Abstract: The intricate behavior of particle acceleration and transport mechanisms complicates the overall efforts in formulating a comprehensive understanding of solar energetic particle (SEP) events; these efforts include observations of low-energy particles (from tens of keV to hundreds of MeV) by space-borne instruments and measurements by the ground-based neutron monitors of the secondary particles generated in the Earth atmosphere by SEPs in the GeV range. Numerous space-borne missions provided good data on the nature/characteristics of these solar particles in past solar cycles, but more recently—concurrently with the rise toward the maximum of solar cycle 25—the High-Energy Particle Detector (HEPD-01) proved to be well suited for the study of solar physics and space weather. Its nominal 30–300 MeV energy range for protons can enlarge the detection capabilities of solar particles at low Earth orbit, closer to the injection limit of many SEP events. In this work, we characterize three SEP events within the first six months of 2022 through spectral and velocity dispersion analysis, assessing the response of HEPD-01 to >M1 events.
Published: 2024
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7. Hylin-a1: a new weapon peptide against antibiotic-resistant bacteria

Author: A. Chianese, C. Zannella, R. Giugliano, F. Foglia, R. Della Marca, A. Ambrosino, M.V. Morone, F. Palma, E. Panico, A. Monti, N. Doti, G. Franci, A. De Filippis, and M. Galdiero
Subjects: Microbiology, QR1-502
Abstract: Not available.
Published: 2023
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8. The use of long-acting injectable antipsychotics in an acute psychiatric unit

Author: G. Ortega-Hernández, N. Ramiro, F. Palma-Álvarez, Ó. Soto-Angona, M. F. Mantilla, J. Duque, I. Gonzalo, and F. Collazos
Subjects: Psychiatry, RC435-571
Abstract: Introduction Long-acting injectable antipsychotic (LAI) are an important and arguably under-utilized therapeutic option, particularly where medication adherence is a priority (Pilon et al. Clin Ther 2017; 39 1972-1985). In recent years, meta-analytic reviews of depot medications concluded that this route of administration produced clinical advantages in terms of overall outcome, with lower probability of relapse, readmissions, shorter hospital admission time, mortality, and thus better long- term prognosis over other oral antipsychotics (Leucht et al. Schizophr Res 2011;127 83-92). Depot treatment is associated with lower overall medical expenditure (Taipal et al. Schizophr Bull 2018;17 1381- 1387). Objectives To describe the evolution of people diagnosed with a psychotic disorder 6 months before and after the introduction of long-acting injectable antipsychotic (LAI) in the acute psychiatric unit of San Rafael Hospital (Spain) from January 1, 2018 to December 31, 2018. Methods Retrospective and prospective naturalistic study. Patients with a diagnosis of psychotic disorder who were admitted to the acute psychiatric unit in 2018 and who were introduced to LAI (paliperidone palmitate, aripiprazole, olanzapine pamoate or risperidone), are selected. Sociodemographic variables (sex, age, ethnicity, migratory status, marital status, occupation, cohabitation) and clinical variables (main and secondary diagnosis, comorbidity with drug use and history of poor adherence) are described. The number of emergency visits and hospital admissions before and after the introduction of LAI antipsychotic treatment is compared. Results The sample was composed of 99 subjects. The mean age was 42.46 years (SD 13.439) and 67.7% were men. The socio-demographic profile was: european caucasian ethnicity (73.7%), non- migrant status (69.7%), single (67.7%), inactive (43.4%) and residing in the home of relatives (50.5%). 53.5% have a diagnosis of schizophrenia, followed by schizoaffective disorder (24.2%). 45.5% are diagnosed with any drug use disorder, the most frequent being cannabis (30.3%). 76.8% have a history of discontinuing oral treatment. There was a statistically significant decrease (p
Published: 2023
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9. A Systematic Review and Meta-Analysis of Randomized Controlled Trials on Supine vs. Nonsupine Endotracheal Intubation

Author: Chriselyn F. Palma, Radwan Mashina, Claire Chen, Tareq Arar, Marwan Mashina, Yussef Al Ghoul, Banreet Dhindsa, and Rajany Dy
Subjects: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Background. This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to compare the safety and efficacy of supine vs. nonsupine positions during intubation. Methods. Based on the literature from inception to October 2020, 13 studies with nonemergent intubation in supine and nonsupine positions were chosen using PRISMA and MOOSE protocols. Pooled estimates were calculated using random-effects models with 95% confidence interval (CI). The primary outcome was a successful intubation, attempt, and duration of intubation. The secondary outcome was adverse events (trauma and hypoxia). Bias was evaluated qualitatively, by visual analysis, and quantitatively through the Egger test. Results. The final analysis included 13 clinical trials with 1,916 patients. The pooled success rates in the supine vs. lateral positions were 99.21% and 98.82%. The supine vs. semierect positions were 99.21% and 98.82%. The 1st attempt success rate in the supine vs. lateral position was 85.35% and 88.56% compared to 91.38% and 90.76% for the supine vs. semierect position. The rate of total adverse events in the supine position was 3.73% vs. 6.74% in the lateral position, and the rate of total adverse events in the supine position was 0.44% vs. 0.93% in semierect position. Low to substantial heterogeneity was noted in our analysis. Discussion. There is no significant difference between total successful intubations and success from 1st intubation attempt between supine and nonsupine positions. However, there are slightly higher rates of adverse events in nonsupine position. Addition of more recent studies on supine vs. nonsupine intubations would improve this study. Given these findings, it is important to develop more studies regarding different intubation positions and techniques with the aim of improving efficacy and decreasing adverse outcomes. Other. This review is not registered in a public database. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Published: 2023
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10. Time Dependence of 50–250 MeV Galactic Cosmic-Ray Protons between Solar Cycles 24 and 25, Measured by the High-energy Particle Detector on board the CSES-01 Satellite

Author: M. Martucci, R. Ammendola, D. Badoni, S. Bartocci, R. Battiston, S. Beolè, W. J. Burger, D. Campana, G. Castellini, P. Cipollone, S. Coli, L. Conti, A. Contin, M. Cristoforetti, G. D’Angelo, C. De Donato, C. De Santis, A. Di Luca, F. M. Follega, G. Gebbia, R. Iuppa, A. Lega, M. Lolli, N. Marcelli, G. Masciantonio, M. Mergè, M. Mese, C. Neubüser, F. Nozzoli, A. Oliva, G. Osteria, L. Pacini, F. Palma, F. Palmonari, B. Panico, A. Parmentier, S. Perciballi, F. Perfetto, P. Picozza, M. Pozzato, G. M. Rebustini, E. Ricci, M. Ricci, S. B. Ricciarini, U. Savino, Z. Sahnoun, V. Scotti, A. Sotgiu, R. Sparvoli, P. Ubertini, V. Vilona, V. Vitale, S. Zoffoli, P. Zuccon, O. P. M. Aslam, M. D. Ngobeni, and M. S. Potgieter
Subjects: Active sun, Heliosphere, Galactic cosmic rays, Astrophysics, QB460-466
Abstract: Time-dependent energy spectra of galactic cosmic rays (GCRs) carry crucial information regarding their origin and propagation throughout the interstellar environment. When observed at the Earth, after traversing the interplanetary medium, such spectra are heavily affected by the solar wind and the embedded solar magnetic field permeating the inner sectors of the heliosphere. The activity of the Sun changes significantly over an 11 yr solar cycle—and so does the effect on cosmic particles; this translates into a phenomenon called solar modulation. Moreover, GCR spectra during different epochs of solar activity provide invaluable information for a complete understanding of the plethora of mechanisms taking place in various layers of the Sun’s atmosphere and how they evolve over time. The High-Energy Particle Detector (HEPD-01) has been continuously collecting data since 2018 August, during the quiet phase between solar cycles 24 and 25; the activity of the Sun is slowly but steadily rising and is expected to peak around 2025/2026. In this paper, we present the first spectra for ∼50–250 MeV galactic protons measured by the HEPD-01 instrument—placed on board the CSES-01 satellite—from 2018 August to 2022 March over a one-Carrington-rotation time basis. Such data are compared to the ones from other spaceborne experiments, present (e.g., EPHIN, Parker Solar Probe) and past (PAMELA), and to a state-of-the-art three-dimensional model describing the GCRs propagation through the heliosphere.
Published: 2023
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11. Observation of Anomalous Electron Fluxes Induced by GRB221009A on CSES-01 Low-energy Charged Particle Detector

Author: R. Battiston, C. Neubüser, F. M. Follega, R. Iuppa, V. Vitale, R. Ammendola, D. Badoni, S. Bartocci, A. Bazzano, S. Beolè, I. Bertello, W. J. Burger, D. Campana, A. Cicone, P. Cipollone, S. Coli, L. Conti, A. Contin, M. Cristoforetti, G. D’Angelo, F. De Angelis, C. De Donato, C. De Santis, P. Diego, A. Di Luca, E. Fiorenza, G. Gebbia, A. Lega, M. Lolli, B. Martino, M. Martucci, G. Masciantonio, M. Mergè, M. Mese, A. Morbidini, F. Nuccilli, F. Nozzoli, A. Oliva, G. Osteria, E. Papini, F. Palma, F. Palmonari, A. Parmentier, B. Panico, S. Perciballi, F. Perfetto, A. Perinelli, P. Picozza, M. Piersanti, M. Pozzato, G. Rebustini, D. Recchiuti, E. Ricci, M. Ricci, J. Rodi, A. Russi, S. B. Ricciarini, Z. Sahnoun, U. Savino, V. Scotti, X. Shen, A. Sotgiu, R. Sparvoli, S. Tofani, P. Ubertini, N. Vertolli, V. Vilona, U. Zannoni, Z. Zeren, S. Zoffoli, and P. Zuccon
Subjects: Particle astrophysics, Gamma-ray bursts, Astronomical detectors, Astrophysics, QB460-466
Abstract: High-energy, long gamma-ray bursts (GRBs) can be generated by the core collapse of massive stars at the end of their lives. When they happen in the close-by universe they can be exceptionally bright, as seen from the Earth in the case of the recent, giant, long-lasting GRB221009A. GRB221009A was produced by a collapsing star with a redshift of 0.152: this event was observed by many gamma-ray space experiments, which also detected an extraordinary long gamma-ray afterglow. The exceptionally large fluence of the prompt emission of about 0.013 erg cm ^−2 illuminated a large geographical region centered on India and including Europe and Asia. We report in this paper the observation of sudden electron flux changes correlated with GRB221009A and measured by the HEPP-L charged particle detector on board the China Seismo-Electromagnetic Satellite, which was orbiting over Europe at the time of the GRB event. The time structure of the observed electron flux closely matches the very distinctive time dependence of the photon flux associated with the main part of the emission at around 13:20 UTC on 2022 October 9. To test the origin of these signals, we set up a simplified simulation of one HEPP-L subdetector: the results of this analysis suggest that the signals observed are mostly due to electrons created within the aluminum collimator surrounding the silicon detector, providing real-time monitoring of the very intense photon fluxes. We discuss the implications of this observation for existing and forthcoming particle detectors on low Earth orbits.
Published: 2023
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12. ‘Should I stay or should I go?’: A mixed methods study on nurse retention during challenging times

Author: Michael Joseph S. Diño, Paul John B. Bracero, Arnel Buencamino, Sharon B. Cajayon, Michael William Q. Catajan, Michaela Liel L. De Leon, Jessie Elsid Jr. Gregorio, Pamela Anne A. Lucelo, Bavy Charmy Cindy P. Odon, Jasmin Anne F. Palma, Roi Roel C. Rosado, Martin Phillip D. Taboada, and Maria Luisa Uayan
Subjects: humans, COVID-19, motivation, pandemics, Philippines, health personnel, Nursing, RT1-120
Abstract: Background: The World Health Organization estimates that between 80,000 and 180,000 medical personnel perished as a result of COVID-19. Although studies about nurses’ organizational commitment during the COVID-19 pandemic have been conducted, the sources of motivations and resilience strategies of nurses in providing a quality healthcare service amidst the COVID-19 pandemic have yet to be explored. Objective: This study aimed to investigate how motivation and resilience influence nurses to serve and cater to patients during the COVID-19 pandemic. Methods: A sequential exploratory mixed approach was used in this study between July and August 2022. The Connor-Davidson Resilience Scale (CD-RISC-10), Work Extrinsic and Intrinsic Motivations scale (WEIMS), and Garbee and Killacky’s Intent to Stay Scale (GKISS) were used to measure resilience, motivation, and intention to stay, among 50 nurses within Metro Manila. Quantitative data were analyzed using quantile regression, while qualitative data from eight participants were analyzed using thematic analysis. Results: The majority of the nurses were working 12 hours and above (52%) and earning a bi-weekly income of PHP 15,001 to 20,000 (96%). The GKISS scores of most respondents indicated their likelihood of remaining in their current profession was moderately low (Mdn = 12.5; IQR = 12-14). It was also found that there was no sufficient statistical evidence to conclude that intention to stay was associated with resilience (p = 0.914) and work motivation (p = 0.560). The qualitative strand of this study explored the significant influences of motivation, resilience strategies, and sources of intention to stay among Filipino nurses while facing the COVID-19 pandemic. The primary motivations of nurses lie in family, passion for work, and career development, while the resilience strategies include adaptiveness, time management skills, and self-fulfillments. On the other hand, the intent to stay greatly lies in serving the people and the country. Conclusion: This study concludes that positive and negative resilience and motivations from different facets of the social life of Filipino nurses, including passion, familial ties, patient care, and faith are the antecedents influencing the intention to serve in the healthcare service. In terms of staying for an extended period in a nursing career, the study found that institutionalized interventions, adequate compensation and benefits, and a good workplace are determinants of staying longer in the Philippines as Filipino nurses.
Published: 2022
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13. The incidence of thyroid cancer in focal hypermetabolic thyroid lesions

Author: Barrio, Martin, Czernin, Johannes, Yeh, Michael W, Diaz, Miguel F Palma, Gupta, Pawan, Allen-Auerbach, Martin, Schiepers, Christiaan, and Herrmann, Ken
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Biomedical Imaging, Clinical Research, Rare Diseases, Adult, Aged, Aged, 80 and over, Female, Fluorine Radioisotopes, Fluorodeoxyglucose F18, Humans, Incidence, Incidental Findings, Male, Middle Aged, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals, Retrospective Studies, Thyroid Gland, Thyroid Neoplasms, Young Adult, fluorine-18 fluorodeoxyglucose, incidental findings, PET, thyroid, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract: BackgroundThe clinical significance of incidental thyroid abnormalities discovered in fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) (FDG PET/CT) studies remains controversial. The aim of this large retrospective study was to (a) determine the prevalence of focal F-FDG thyroid uptake on whole-body F-FDG PET/CT studies carried out for nonthyroid cancers and (b) to test whether intense focal F-FDG thyroid uptake is associated with malignancy.Materials and methodsA total of 11 921 F-FDG PET/CT studies in 6216 patients carried out at our institution between January 2012 and December 2014 were analyzed. We retrospectively reviewed the medical records of these patients. Eight hundred and forty-five/6216 (13.6%) patients had a thyroid incidentaloma on the basis of the clinical F-FDG PET/CT report. One hundred and sixty/845 (18.9%) of these underwent ultrasound and 98 (61.3%) of these underwent a fine-needle aspiration (FNA). Twenty-six of these 98 (26.5%) patients underwent thyroidectomy. Thyroid lesion and background standardized uptake value (SUVs) for each patient were measured upon review of the F-FDG PET/CT study. We measured maximum standardized uptake value (SUVmax), thyroid to background TL/TBG, thyroid to bloodpool TL/BP and thyroid to liver TL/L ratios in benign and malignant lesions. Receiver operating curves were calculated to determine optimal cut-off values between malignant and benign lesions.ResultsTwenty-one of the 98 patients who underwent FNA biopsy or thyroidectomy had malignant disease (21.4%). Malignant lesions had significantly higher thyroid lesion SUVmax, TL/TBG, TL/BP, and TL/L than benign nodules. The receiver operating curves derived cut-off ratio TL/TBG of more than 2.0 differentiated benign from malignant lesions best with a specificity and sensitivity of 0.76 and 0.88, respectively.ConclusionThe incidence of malignancy in biopsied focal hypermetabolic thyroid lesions is 21.4%. Lesions on F-FDG PET/CT studies, with a ratio TL/TBG more than 2.0, warrant further work-up with ultrasound and FNA to exclude malignancy.
Published: 2016

14. Silicon Nanowires as Contact Between the Cell Membrane and CMOS Circuits.

Author: P. Piedimonte, D. A. M. Feyen, M. Mercola, E. Messina, M. Renzi, and F. Palma
Published: 2019
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15. Microwave driven synthesis of narrow bandgap alpha-tin nanoparticles on silicon

Author: I. Mazzetta, L. Viti, F. Rigoni, S. Quaranta, A. Gasparotto, G. Barucca, F. Palma, P. Riello, E. Cattaruzza, M. Asgari, M. Vitiello, and F. Irrera
Subjects: Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract: This work proposes a microwave-based synthetic route for the preparation of tin nanospheres with a diamond-like α-phase structure on silicon. The main characteristics of the synthesized material are an extraordinarily narrow (around 50 meV) direct bandgap and an improved thermal stability (up to 200° C). Structural and compositional characterizations showed a core–shell structure comprised of an outer amorphous oxide shell and inner core containing α-phase tin domains. Microwaves turned out to be instrumental in achieving the specific nanostructures reported, due to their peculiar heating characteristics. Low pressure, low temperature and compatibility with integrated circuits manufacturing represent the most innovative features of the present synthetic process.
Published: 2022
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16. Plasma-based longitudinal mutation monitoring as a potential predictor of disease progression in subjects with adenocarcinoma in advanced non-small cell lung cancer

Author: John Jiang, Hans-Peter Adams, Maria Lange, Sandra Siemann, Mirjam Feldkamp, Sylvie McNamara, Sebastian Froehler, Stephanie J. Yaung, Lijing Yao, Aarthi Balasubramanyam, Nalin Tikoo, Christine Ju, H. Jost Achenbach, Rainer Krügel, and John F. Palma
Subjects: Next-generation sequencing (NGS), Cell-free DNA (cfDNA), Circulating tumor DNA (ctDNA), Liquid biopsy, Non-small cell lung cancer (NSCLC), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Identifying and tracking somatic mutations in cell-free DNA (cfDNA) by next-generation sequencing (NGS) has the potential to transform the clinical management of subjects with advanced non-small cell lung cancer (NSCLC). Methods Baseline tumor tissue (n = 47) and longitudinal plasma (n = 445) were collected from 71 NSCLC subjects treated with chemotherapy. cfDNA was enriched using a targeted-capture NGS kit containing 197 genes. Clinical responses to treatment were determined using RECIST v1.1 and correlations between changes in plasma somatic variant allele frequencies and disease progression were assessed. Results Somatic variants were detected in 89.4% (42/47) of tissue and 91.5% (407/445) of plasma samples. The most commonly mutated genes in tissue were TP53 (42.6%), KRAS (25.5%), and KEAP1 (19.1%). In some subjects, the allele frequencies of mutations detected in plasma increased 3–5 months prior to disease progression. In other cases, the allele frequencies of detected mutations declined or decreased to undetectable levels, indicating clinical response. Subjects with circulating tumor DNA (ctDNA) levels above background had significantly shorter progression-free survival (median: 5.6 vs 8.9 months, respectively; log-rank p = 0.0183). Conclusion Longitudinal monitoring of mutational changes in plasma has the potential to predict disease progression early. The presence of ctDNA mutations during first-line treatment is a risk factor for earlier disease progression in advanced NSCLC.
Published: 2020
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17. Efficacy of liquid biopsy for disease monitoring and early prediction of tumor progression in EGFR mutation-positive non-small cell lung cancer.

Author: Hsiang-Ling Ho, Yuqiu Jiang, Chi-Lu Chiang, Sylwia Karwowska, Ranga Yerram, Keerti Sharma, Sidney Scudder, Chao-Hua Chiu, Chun-Ming Tsai, John F Palma, Abha Sharma, and Teh-Ying Chou
Subjects: Medicine, Science
Abstract: 15-40% of non-small cell lung cancer (NSCLC) patients harbor epidermal growth factor receptor (EGFR)-sensitizing mutations. Tyrosine kinase inhibitors (TKIs) provide significant clinical benefit in this population, yet all patients will ultimately progress. Liquid biopsy can reliably identify somatic tumor-associated EGFR mutations in plasma. This study aimed to assess the feasibility and value of the quantitative assessment of EGFR driver mutations in plasma in EGFR-mutated NSCLC patients treated with EGFR-TKIs as a tool to evaluate therapeutic response to TKIs and monitor for disease progression. The study included 136 patients with tissue biopsy-confirmed EGFR-sensitizing, mutation-positive lung adenocarcinoma with plasma collected prior to TKI treatment and at least two post-initiation TKI treatment/follow-up blood samples. Plasma samples were tested with the cobas® EGFR Mutation Test v2 (cobas EGFR Test), and semi-quantitative index (SQI) values for each identified mutation were reported by the assay software. The most common baseline EGFR mutations detected in tissue were L858R (53.7%) and exon 19 deletion (39.7%). Plasma cell-free DNA analysis detected EGFR mutations in 74% of the baseline samples. Objective response rate by RECIST 1.1 was achieved in 72% of patients, while 93% had a molecular response (defined as disappearance of the EGFR mutation from plasma). 83% of patients had molecular progression (MP; 1.5X SQI increase or new T790M mutation), and 82% who had a clinical response had clinical progression. On average, MP occurred 42 days prior to clinical progression. Patients who progressed while on first-line TKI showed MP of the original EGFR-sensitizing mutations prior to the emergence of a T790M mutation, which was detected in 27% of the EGFR plasma-positive patients. Longitudinal monitoring of EGFR mutational load in plasma is feasible and can predict both response and clinical progression in EGFR-mutated NSCLC patients treated with EGFR-TKIs, as well as detect treatment-emergent EGFR mutations.
Published: 2022
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18. Gamma-Ray Burst Observations by the High-Energy Particle Detector on board the China Seismo-Electromagnetic Satellite between 2019 and 2021

Author: F. Palma, M. Martucci, C. Neubüser, A. Sotgiu, F. M. Follega, P. Ubertini, A. Bazzano, J. C. Rodi, R. Ammendola, D. Badoni, S. Bartocci, R. Battiston, S. Beolè, I. Bertello, W. J. Burger, D. Campana, A. Cicone, P. Cipollone, S. Coli, L. Conti, A. Contin, M. Cristoforetti, G. D’Angelo, F. De Angelis, C. De Donato, C. De Santis, P. Diego, A. Di Luca, E. Fiorenza, G. Gebbia, R. Iuppa, A. Lega, M. Lolli, B. Martino, G. Masciantonio, M. Mergè, M. Mese, A. Morbidini, F. Nozzoli, F. Nuccilli, A. Oliva, G. Osteria, F. Palmonari, B. Panico, E. Papini, A. Parmentier, S. Perciballi, F. Perfetto, A. Perinelli, P. Picozza, M. Piersanti, M. Pozzato, G. Rebustini, D. Recchiuti, E. Ricci, M. Ricci, S. B. Ricciarini, A. Russi, Z. Sahnoun, U. Savino, V. Scotti, X. Shen, R. Sparvoli, S. Tofani, N. Vertolli, V. Vilona, V. Vitale, U. Zannoni, Z. Zeren, S. Zoffoli, and P. Zuccon
Subjects: Cosmic ray detectors, Gamma-ray bursts, Particle astrophysics, Astrophysics, QB460-466
Abstract: In this paper we report the detection of five strong gamma-ray bursts (GRBs) by the High-Energy Particle Detector (HEPD-01) mounted on board the China Seismo-Electromagnetic Satellite, operational since 2018 on a Sun-synchronous polar orbit at a ∼507 km altitude and 97° inclination. HEPD-01 was designed to detect high-energy electrons in the energy range 3–100 MeV, protons in the range 30–300 MeV, and light nuclei in the range 30–300 MeV n ^−1 . Nonetheless, Monte Carlo simulations have shown HEPD-01 is sensitive to gamma-ray photons in the energy range 300 keV–50 MeV, even if with a moderate effective area above ∼5 MeV. A dedicated time correlation analysis between GRBs reported in literature and signals from a set of HEPD-01 trigger configuration masks has confirmed the anticipated detector sensitivity to high-energy photons. A comparison between the simultaneous time profiles of HEPD-01 electron fluxes and photons from GRB190114C, GRB190305A, GRB190928A, GRB200826B, and GRB211211A has shown a remarkable similarity, in spite of the different energy ranges. The high-energy response, with peak sensitivity at about 2 MeV, and moderate effective area of the detector in the actual flight configuration explain why these five GRBs, characterized by a fluence above ∼3 × 10 ^−5 erg cm ^−2 in the energy interval 300 keV–50 MeV, have been detected.
Published: 2023
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19. Insomnia Disorder in Adult Attention-Deficit/Hyperactivity Disorder Patients: Clinical, Comorbidity, and Treatment Correlates

Author: Christian Fadeuilhe, Constanza Daigre, Vanesa Richarte, Lara Grau-López, Raul F. Palma-Álvarez, Montse Corrales, and Josep A. Ramos-Quiroga
Subjects: attention deficit and hyperactivity disorder, insomnia disorder, adult ADHD, sleep disorder, severity, comorbidity, Psychiatry, RC435-571
Abstract: Introduction: Several investigations have been performed on insomnia symptoms in adult attention-deficit/hyperactivity disorder (ADHD). However, the relationship between insomnia disorder and adult ADHD has been neglected in research. The main objective of the current study is to analyze the differences between adult ADHD patients with and without insomnia disorder, in terms of ADHD clinical severity, medical and psychiatric comorbidity, psychopharmacological treatment, and quality of life.Material and Methods: Two hundred and fifty-two adult patients with ADHD (mean age 37.60 ± 13.22 years; ADHD presentations—combined: 56.7%, inattentive: 39.7%, hyperactive/impulsive: 3.6%) were evaluated with an exhaustive clinical and psychological evaluation protocol including semistructured interviews (for comorbidities and ADHD assessment) and symptom rating scales for ADHD. The diagnosis of ADHD and insomnia disorder was made according to DSM-5 criteria. Furthermore, the Pittsburgh Sleep Quality Index, Insomnia Severity Index, and Epworth Sleepiness Scale were administered.Results: Insomnia disorder was found in 44.4% of adult ADHD patients and was more common in combined presentation (64.3%) and in patients with more ADHD severity. Comorbidities (both medical and psychiatric), especially mood disorders (42%), anxiety disorder (26.8%), personality disorder (39.3%), and any substance use disorder (11.6%), were associated with a higher insomnia disorder prevalence. ADHD stimulant treatment was related to lower insomnia disorder compared to patients without medication, as well as ADHD stable treatment. Additionally, worse health-related quality of life was associated with insomnia disorder.Conclusion: Insomnia disorder is highly prevalent in adult ADHD and is related to higher ADHD severity and more psychiatric and medical comorbidities. Some stimulants and stable pharmacological ADHD treatment are associated with better outcomes of insomnia disorder.
Published: 2021
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20. Alexithymia in Patients With Substance Use Disorders and Its Relationship With Psychiatric Comorbidities and Health-Related Quality of Life

Author: Raul F. Palma-Álvarez, Elena Ros-Cucurull, Constanza Daigre, Marta Perea-Ortueta, Pedro Serrano-Pérez, Nieves Martínez-Luna, Anna Salas-Martínez, María Robles-Martínez, Josep A. Ramos-Quiroga, Carlos Roncero, and Lara Grau-López
Subjects: alexithymia, anxiety, depression, health-related quality of life, impulsivity, substance use disorder, Psychiatry, RC435-571
Abstract: Background: Alexithymia frequently correlates with several psychiatric disorders, including substance use disorder (SUD). However, most studies reporting the associations between alexithymia and psychiatric disorders have been performed in populations without SUD. This research, therefore, evaluates alexithymia in Spanish patients with SUD and the relationship among alexithymia, psychiatric comorbidities, psychological symptoms/traits, SUD variables, and health-related quality of life (HRQoL).Methodology: A cross-sectional study was conducted with 126 Spanish outpatients with SUD (75.4% males; mean age 43.72 ± 14.61 years), correlating their alexithymia levels (using the Toronto Alexithymia Scale 20 [TAS-20]) to their psychiatric comorbidities, psychological symptoms/traits, SUD variables, and HRQoL.Results: Alexithymia was significantly higher in patients who had cannabis use disorder. Higher alexithymia scores were also related to higher levels of depression, anxiety, impulsivity, and lower HRQoL. After multivariate analysis, trait anxiety, impulsivity, and the physical component summary of the HRQoL were found to be independently related to alexithymia.Conclusions: SUD patients with higher alexithymia levels have more frequently psychiatric comorbidities, present specific psychological features, and have worse HRQoL. Hence, it is important to evaluate these factors and offer more accurate psychotherapeutic approaches for this patient population.
Published: 2021
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21. Transcriptomic changes in Cucurbita pepo fruit after cold storage: differential response between two cultivars contrasting in chilling sensitivity

Author: F. Carvajal, R. Rosales, F. Palma, S. Manzano, J. Cañizares, M. Jamilena, and D. Garrido
Subjects: Zucchini fruit, Postharvest physiology, Cold tolerance, Transcriptomic profiling, Stress response, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract: Abstract Background Zucchini fruit is susceptible to chilling injury (CI), but the response to low storage temperature is cultivar dependent. Previous reports about the response of zucchini fruit to chilling storage have been focused on the physiology and biochemistry of this process, with little information about the molecular mechanisms underlying it. In this work, we present a comprehensive analysis of transcriptomic changes that take place after cold storage in zucchini fruit of two commercial cultivars with contrasting response to chilling stress. Results RNA-Seq analysis was conducted in exocarp of fruit at harvest and after 14 days of storage at 4 and 20 °C. Differential expressed genes (DEGs) were obtained comparing fruit stored at 4 °C with their control at 20 °C, and then specific and common up and down-regulated DEGs of each cultivar were identified. Functional analysis of these DEGs identified similarities between the response of zucchini fruit to low temperature and other stresses, with an important number of GO terms related to biotic and abiotic stresses overrepresented in both cultivars. This study also revealed several molecular mechanisms that could be related to chilling tolerance, since they were up-regulated in cv. Natura (CI tolerant) or down-regulated in cv. Sinatra (CI sensitive). These mechanisms were mainly those related to carbohydrate and energy metabolism, transcription, signal transduction, and protein transport and degradation. Among DEGs belonging to these pathways, we selected candidate genes that could regulate or promote chilling tolerance in zucchini fruit including the transcription factors MYB76-like, ZAT10-like, DELLA protein GAIP, and AP2/ERF domain-containing protein. Conclusions This study provides a broader understanding of the important mechanisms and processes related to coping with low temperature stress in zucchini fruit and allowed the identification of some candidate genes that may be involved in the acquisition of chilling tolerance in this crop. These genes will be the basis of future studies aimed to identify markers involved in cold tolerance and aid in zucchini breeding programs.
Published: 2018
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22. Direct Measurement of the Cosmic-Ray Carbon and Oxygen Spectra from 10 GeV/n to 2.2 TeV/n with the Calorimetric Electron Telescope on the International Space Station

Author: O. Adriani, Y. Akaike, K. Asano, Y. Asaoka, M. G. Bagliesi, E. Berti, G. Bigongiari, W. R. Binns, M. Bongi, P. Brogi, A. Bruno, J. H. Buckley, N. Cannady, G. Castellini, C. Checchia, M. L. Cherry, G. Collazuol, K. Ebisawa, H. Fuke, S. Gonzi, T. G. Guzik, T. Hams, K. Hibino, M. Ichimura, K. Ioka, W. Ishizaki, M. H. Israel, K. Kasahara, J. Kataoka, R. Kataoka, Y. Katayose, C. Kato, N. Kawanaka, Y. Kawakubo, K. Kobayashi, K. Kohri, H. S. Krawczynski, J. F. Krizmanic, J. Link, P. Maestro, P. S. Marrocchesi, A. M. Messineo, J. W. Mitchell, S. Miyake, A. A. Moiseev, M. Mori, N. Mori, H. M. Motz, K. Munakata, S. Nakahira, J. Nishimura, G. A. De Nolfo, S. Okuno, J. F. Ormes, N. Ospina, S. Ozawa, L. Pacini, F. Palma, P. Papini, B. F. Rauch, S. B. Ricciarini, K. Sakai, T. Sakamoto, M. Sasaki, Y. Shimizu, A. Shiomi, R. Sparvoli, P. Spillantini, F. Stolzi, S. Sugita, J. E. Suh, A. Sulaj, M. Takita, T. Tamura, T. Terasawa, S. Torii, Y. Tsunesada, Y. Uchihori, E. Vannuccini, J. P. Wefel, K. Yamaoka, S. Yanagita, A. Yoshida, and K. Yoshida
Subjects: Astrophysics
Abstract: In this paper, we present the measurement of the energy spectra of carbon and oxygen in cosmic rays based on observations with the Calorimetric Electron Telescope on the International Space Station from October 2015 to October 2019. Analysis, including the detailed assessment of systematic uncertainties, and results are reported. The energy spectra are measured in kinetic energy per nucleon from 10 GeV/n to 2.2 TeV/n with an all-calorimetric instrument with a total thickness corresponding to 1.3 nuclear interaction length. The observed carbon and oxygen fluxes show a spectral index change of ∼0.15 around 200 GeV/n established with a significance > 3σ. They have the same energy dependence with a constant C/O flux ratio 0.911 ± 0.006 above 25 GeV/n. The spectral hardening is consistent with that measured by AMS-02, but the absolute normalization of the flux is about 27% lower, though in agreement with observations from previous experiments including the PAMELA spectrometer and the calorimetric balloon-borne experiment CREAM.
Published: 2020
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23. CALET on the International Space Station: the first three years of observations

Author: P Brogi, O Adriani, Y Akaike, K Asano, Y Asaoka, M G Bagliesi, E Berti, G Bigongiari, W R Binns, S Bonechi, M Bongi, A Bruno, J H Buckley, N Cannady, G Castellini, C Checchia, M L Cherry, G Collazuol, V Di Felice, K Ebisawa, H Fuke, T G Guzik, T Hams, K Hibino, M Ichimura, K Ioka, W Ishizaki, M H Israel, K Kasahara, J Kataoka, R Kataoka, Y Katayose, C Kato, N Kawanaka, Y Kawakubo, K Kohri, H S Krawczynski, J F Krizmanic, J Link, P Maestro, P S Marrocchesi, A M Messineo, J W Mitchell, S Miyake, A A Moiseev, M Mori, N. Mori, H M Motz, K Munakata, H Murakami, S Nakahira, J Nishimura, G A de Nolfo, S Okuno, J F Ormes, N Ospina, S Ozawa, L Pacini, F Palma, P Papini, B F Rauch, S B Ricciarini, K Saka, T Sakamoto, M Sasaki, Y Shimizu, A Shiomi, R Sparvoli, P Spillantini, F Stolzi, S Sugita, J E Suh, A Sulaj, I Takahashi, M Takita, T Tamura, T Terasawa, S Torii, Y Tsunesada, Y Uchihori, E Vannuccini, J P Wefel, K Yamaoka, S Yanagita, A Yoshida, and K Yoshida
Subjects: Instrumentation And Photography, Astrophysics
Abstract: The CALorimetric Electron Telescope CALET is a space instrument designed to carry out precision measurements of high energy cosmic-rays on the JEM-EF external platform on the International Space Station, where it has been collecting science data continuously since mid-October 2015. In addition to its primary goal of identifying nearby sources of high-energy electrons and possible signatures of dark matter in the electron spectrum, CALET is carrying out extensive measurements of the energy spectra, relative abundances and secondary-to-primary ratios of elements from proton to iron, and even above (up to Z = 40), studying the details of galactic particle propagation and acceleration. An overview of CALET based on the data taken during the first three years of observations is presented, including a direct measurement of the electron+positron energy spectrum from 11 GeV to 4.8 TeV. The proton spectrum has been measured from 50 GeV to 10 TeV covering, for the first time with a single space-borne instrument, the whole energy interval previously investigated in separate sub-ranges by magnetic spectrometers and calorimetric instruments. Preliminary spectra of cosmic-ray nuclei are also presented, together with gamma-ray observations and searches for an e.m. counterpart of LIGO/ Virgo GW events.
Published: 2020
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24. CALET Results after Three Years on the International Space Station

Author: Y Asaoka, O Adriani, Y Akaike, K Asano, M G Bagliesi, E Berti, G Bigongiari, W R Binns, S Bonechi, M Bongi, A Bruno, J H Buckley, N Cannady, G Castellini, C Checchia, M L Cherry, G Collazuol, V Di Felice, K Ebisawa, H Fuke, T G Guzik, T Hams, K Hibino, M Ichimura, K Ioka, W Ishizaki, M H Israel, K Kasahara, J Kataoka, R Kataoka, Y Katayose, C Kato, N Kawanaka, Y Kawakubo, K Kohri, H S Krawczynski, J F Krizmanic, J Link, P Maestro, P S Marrocchesi, A M Messineo, J W Mitchell, S Miyake, A A Moiseev, M Mori, H M Motz, K Munakata, S Nakahira, J Nishimura, G A De Nolfo, S Okuno, N Opsina, J F Ormes, S Ozawa, L Pacini, F Palma, V Pal'shin, P Papini, B F Rauch, S B Ricciarini, K Sakai, T Sakamoto, M Sasaki, Y Shimizu, A Shiomi, R Sparvoli, P Spillantini, F Stolzi, S Sugita, J E Suh, A Sulaj, I Takahashi, M Takita, T Tamura, T Terasawa, S Torii, Y Tsunesada, Y Uchihori, E Vannuccini, J P Wefel, K Yamaoka, S Yanagita, A Yoshida, and K Yoshida
Subjects: Astronomy
Abstract: The CALET (CALorimetric Electron Telescope) space experiment, which is currently conducting direct cosmic-ray observations onboard the International Space Station (ISS), is an all-calorimetric instrument optimized for cosmic-ray electron measurements with capability to measure hadrons and gamma-rays. Since the start of observation in October 2015, smooth and continuous operations have taken place. In this paper, we will give a brief summary of the CALET observations ranging from charged cosmic rays, gamma-rays, to space weather, while focusing on the energy spectra of electrons and protons.
Published: 2020
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25. Application of different DNA extraction procedures, library preparation protocols and sequencing platforms: impact on sequencing results

Author: F. Pasquali, I. Do Valle, F. Palma, D. Remondini, G. Manfreda, G. Castellani, R.S. Hendriksen, and A. De Cesare
Subjects: Bioinformatics, Genetics, Microbiology, Molecular biology, De novo assembly statistics, SNPs calling, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: In this study three DNA extraction procedures, two library preparation protocols and two sequencing platforms were applied to analyse six bacterial cultures and their corresponding DNA obtained as part of a proficiency test. The impact of each variable on sequencing results was assessed using the following parameters: reads quality, assembly and alignment statistics; number of single nucleotide polymorphisms (SNPs), detected applying assembly- and alignment-based strategies; antimicrobial resistance genes (ARGs), identified on de novo assemblies of all sequenced genomes. The investigated nucleic acid extraction procedures, library preparation kits and sequencing platforms do not significantly affect de novo assembly statistics and number of SNPs and ARGs. The only exception was observed for two duplicates, which were associated to one PCR-based library preparation kit. Results from this comparative study can support researchers in the choice toward the available pre-sequencing and sequencing options, and might suggest further comparisons to be performed.
Published: 2019
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26. Mood Disorders and Severity of Addiction in Alcohol-Dependent Patients Could Be Mediated by Sex Differences

Author: Raul F. Palma-Álvarez, Laia Rodríguez-Cintas, Alfonso C. Abad, Marta Sorribes, Elena Ros-Cucurull, María Robles-Martínez, Lara Grau-López, Lourdes Aguilar, and Carlos Roncero
Subjects: alcohol, dependence, depression, suicide attempts, severity, sex differences, Psychiatry, RC435-571
Abstract: Background: Alcohol dependence is highly prevalent in the general population; some differences in alcohol use and dependence between women and men have been described, including outcomes and ranging from biological to social variables. This study aims to compare the severity of alcohol dependence with clinical and psychopathological characteristics between sexes.Methods: A cross-sectional descriptive study was conducted in alcohol-dependent outpatients; the recruitment period was 7 years. The assessment of these patients was carried out by obtaining sociodemographic characteristics and using the Semi-structured Clinical Interview for Axis I and II (SCID-I and SCID-II), European version of the Addiction Severity Index (EuropASI), Beck Depression Inventory (BDI), and State–Trait Anxiety Inventory (STAI) scales. Variables were compared and analyzed.Results: The sample was composed of 178 patients (74.2% males and 25.8% females) with a mean age of 46.52 ± 9.86. No sociodemographic differences were found between men and women. Females had a higher rate of suicide attempts and depression symptoms at the treatment onset. When results of EuropASI were compared, females had worse psychological and employment results than males. According to consumption variables, males had an earlier onset of alcohol use, had more regular alcohol use, and develop alcohol dependence earlier than females.Conclusions: According to results, there are sex-dependent differences (severity and other variables such as mood or suicide) in alcohol dependence. Thus, this may implicate the need of future specific research and treatment programs based on the specific necessities of each sex.
Published: 2019
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27. Transplantation of Human Neural Progenitor Cells (NPC) into Putamina of Parkinsonian Patients: A Case Series Study, Safety and Efficacy Four Years after Surgery

Author: I. Madrazo, O. Kopyov, M. A. Ávila-Rodríguez, F. Ostrosky, H. Carrasco, A. Kopyov, A. Avendaño-Estrada, F. Jiménez, E. Magallón, C. Zamorano, G. González, T. Valenzuela, R. Carrillo, F. Palma, R. Rivera, R. E. Franco-Bourland, and G. Guízar-Sahagún
Subjects: Medicine
Abstract: Individuals with Parkinson’s disease (PD) suffer from motor and mental disturbances due to degeneration of dopaminergic and non-dopaminergic neuronal systems. Although they provide temporary symptom relief, current treatments fail to control motor and non-motor alterations or to arrest disease progression. Aiming to explore safety and possible motor and neuropsychological benefits of a novel strategy to improve the PD condition, a case series study was designed for brain grafting of human neural progenitor cells (NPCs) to a group of eight patients with moderate PD. A NPC line, expressing Oct-4 and Sox-2, was manufactured and characterized. Using stereotactic surgery, NPC suspensions were bilaterally injected into patients’ dorsal putamina. Cyclosporine A was given for 10 days prior to surgery and continued for 1 month thereafter. Neurological, neuropsychological, and brain imaging evaluations were performed pre-operatively, 1, 2, and 4 years post-surgery. Seven of eight patients have completed 4-year follow-up. The procedure proved to be safe, with no immune responses against the transplant, and no adverse effects. One year after cell grafting, all but one of the seven patients completing the study showed various degrees of motor improvement, and five of them showed better response to medication. PET imaging showed a trend toward enhanced midbrain dopaminergic activity. By their 4-year evaluation, improvements somewhat decreased but remained better than at baseline. Neuropsychological changes were minor, if at all. The intervention appears to be safe. At 4 years post-transplantation we report that undifferentiated NPCs can be delivered safely by stereotaxis to both putamina of patients with PD without causing adverse effects. In 6/7 patients in OFF condition improvement in UPDRS III was observed. PET functional scans suggest enhanced putaminal dopaminergic neurotransmission that could correlate with improved motor function, and better response to L-DOPA. Patients’ neuropsychological scores were unaffected by grafting. Trial Registration: Fetal derived stem cells for Parkinson’s disease https://doi.org/10.1186/ISRCTN39104513Reg#ISRCTN39104513
Published: 2019
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28. Default Values And Read-Across Proposal For Dermal Absorption Based On Human Skin In Vitro Studies Dataset With Pesticides

Author: D. Sarti, J. Wagner, F. Palma, H. Kalvan, M. Giachini, D. Lautenschalaeger, V. Lupianhez, J. Pires, M. Sales, P. Faria, L. Bertomeu, and M. Le Bras
Abstract: The skin is the main route of exposure to plant protection products for operators, workers, residents, and bystanders. Assessing dermal absorption is key for evaluating pesticide exposure risks. However, conducting in vitro dermal absorption studies using human skin is resource-intensive. Therefore, establishing realistic regulatory default values is essential for non-dietary risk assessment and ensuring safety. This project analysed 468 in vitro dermal absorption studies with human skin compiled by ProHuma. Combined with a prior database by Aggarwal et al. (2015), the dataset comprised 759 GLP-compliant studies covering 25 formulation types and 248 active substances at various concentrations. The assessment confirmed earlier findings that dermal absorption shows no correlation with molecular weight or log Pow and does not increase linearly with dilution. Based on the comprehensive ProHuma/ECPA dataset, dermal absorption default values are proposed: 2% for solid concentrates, 5% for liquid concentrates, 30% for solid dilutions, and 34% for liquid dilutions. These values, derived conservatively using the 95th percentile, better represent formulations and agricultural use cases, reducing the need for unnecessary studies. The project also suggests read-across between different formulation types. By proposing more realistic default values and read-across approaches, it streamlines decision-making and supports safety in agriculture.
Published: 2023

29. Figure S7 from Disease Monitoring Using Post-induction Circulating Tumor DNA Analysis Following First-Line Therapy in Patients with Metastatic Colorectal Cancer

Author: John F. Palma, Stephanie J. Yaung, Lijing Yao, Nalin Tikoo, Nicolas Sommer, Richard Price, Alan Nicholas, Christoph Mancao, Alex Lovejoy, John J. Lee, Christine Ju, Herbert I. Hurwitz, Johanna C. Bendell, and Xiaoju Max Ma
Abstract: Supplementary Figure
Published: 2023

30. Table S2 from Disease Monitoring Using Post-induction Circulating Tumor DNA Analysis Following First-Line Therapy in Patients with Metastatic Colorectal Cancer

Author: John F. Palma, Stephanie J. Yaung, Lijing Yao, Nalin Tikoo, Nicolas Sommer, Richard Price, Alan Nicholas, Christoph Mancao, Alex Lovejoy, John J. Lee, Christine Ju, Herbert I. Hurwitz, Johanna C. Bendell, and Xiaoju Max Ma
Abstract: Supplementary Table 2
Published: 2023

31. Data from Disease Monitoring Using Post-induction Circulating Tumor DNA Analysis Following First-Line Therapy in Patients with Metastatic Colorectal Cancer

Author: John F. Palma, Stephanie J. Yaung, Lijing Yao, Nalin Tikoo, Nicolas Sommer, Richard Price, Alan Nicholas, Christoph Mancao, Alex Lovejoy, John J. Lee, Christine Ju, Herbert I. Hurwitz, Johanna C. Bendell, and Xiaoju Max Ma
Abstract: Purpose:We assessed plasma circulating tumor DNA (ctDNA) level as a prognostic marker for progression-free survival (PFS) following first-line metastatic colorectal cancer (mCRC) therapy.Experimental Design:The Sequencing Triplet With Avastin and Maintenance (STEAM) was a randomized, phase II trial investigating efficacy of bevacizumab (BEV) plus 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX) and 5-fluorouracil/leucovorin/irinotecan (FOLFIRI), administered concurrently or sequentially, versus FOLFOX-BEV in first-line mCRC. Evaluation of biomarkers associated with treatment outcomes was an exploratory endpoint. Patients in the biomarker-evaluable population (BEP) had 1 tissue sample, 1 pre-induction plasma sample, and 1 post-induction plasma sample collected ≤60 days of induction from last drug date.Results:Among the 280 patients enrolled in STEAM, 183 had sequenced and evaluable tumor tissue, 118 had matched pre-induction plasma, and 54 (BEP) had ctDNA-evaluable sequencing data for pre- and post-induction plasma. The most common somatic variants in tumor tissue and pre-induction plasma were TP53, APC, and KRAS. Patients with lower-than-median versus higher-than-median post-induction mean allele fraction (mAF) levels had longer median PFS (17.7 vs. 7.5 months, HR, 0.33; 95% confidence interval, 0.17–0.63). Higher levels of post-induction mAF and post-induction mean mutant molecules per milliliter (mMMPM), and changes in ctDNA (stratified by a 10-fold or 100-fold reduction in mAF between pre- and post-induction plasma), were associated with shorter PFS. Post-induction mAF and mMMPM generally correlated with each other (ρ = 0.987, P < 0.0001).Conclusions:ctDNA quantification in post-induction plasma may serve as a prognostic biomarker for mCRC post-treatment outcomes.
Published: 2023

32. Digital Workflow in Oral and Maxillofacial Surgery

Author: Daniel Negrelle, Alexandre M. Borba, Isabella Romão Candido, Shaban M. Burgoa, Luiz F. Palma, and Arthur R.G. Cortes
Published: 2022

33. CALET Results After Three Years on Orbit on the International Space Station

Author: P Maestro, O. Adriani, E. Berti, M. Bongi, Y. Akaike, Y. Asaoka, G. Bigongiari, P. Brogi, P. S. Marrocchesi, A. Bruno, N. Cannady, M. L. Cherry, T. G. Guzik, Y. Kawakubo, J. P. Wefel, M. Ichimura, M. H. Israel, B. F. Rauch, K. Kasahara, J. F. Krizmanic, A. M. Messineo, J W Mitchell, S. Miyake, M. Mori, N. Mori, L. Pacini, P. Papini, H. M. Motz, K. Munakata, F. Palma, S. B. Ricciarini, T. Sakamoto, T. Tamura, S. Torii, and K. Yoshida
Subjects: Astrophysics
Abstract: The CALorimetric Electron Telescope (CALET) is an astroparticle physics experiment installed on the International Space Station since August 2015. The CALET mission was conceived to address several outstanding questions of high-energy astroparticle physics, like indirect detection of dark matter, the origin of cosmic rays (CRs), their mechanisms of acceleration and galactic propagation, the presence of possible nearby astrophysical CR sources. That can be achieved by precise measurements of the fluxes of CR electrons and gamma-rays up to the unexplored region above 1 TeV, and the energy spectra and composition of CR nuclei from a few tens of GeV to hundreds of TeV. In order to perform these observations, the instrument combines a thick total absorption PWO crystal calorimeter for energy measurement, a scintillator hodoscope for charge identi�cation and thin imaging tungsten-scintillating �fiber calorimeter providing accurate particle tracking and complementary charge measurement. In this paper, we will present an overview of the main CALET results based on the data collected in the first three years of the mission.
Published: 2019
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34. Direct Measurement of the Cosmic-Ray Proton Spectrum from 50 GeV to 10 TeV with the Calorimetric Electron Telescope on the International Space Station

Author: O. Adriani, Y. Akaike, K. Asano, Y. Asaoka, M. G. Bagliesi, E. Berti, G. Bigongiari, W. R. Binns, S. Bonechi, M. Bongi, P. Brogi, A. Bruno, J. H. Buckley, N. Cannady, G. Castellini, C. Checchia, M. L. Cherry, G. Collazuol, V. Di Felice, K. Ebisawa, H. Fuke, T. G. Guzik, T. Hams, N. Hasebe, K. Hibino, M. Ichimura, K. Ioka, W. Ishizaki, M. H. Israel, K. Kasahara, J. Kataoka, R. Kataoka, Y. Katayose, C. Kato, N. Kawanaka, Y. Kawakubo, K. Kohri, H. S. Krawczynski, J. F. Krizmanic, T. Lomtadze, P. Maestro, P. S. Marrocchesi, A. M. Messineo, J. W. Mitchell, S. Miyake, A. A. Moiseev, K. Mori, M. Mori, N. Mori, H. M. Motz, K. Munakata, H. Murakami, S. Nakahira, J. Nishimura, G. A. de Nolfo, S. Okuno, J. F. Ormes, S. Ozawa, L. Pacini, F. Palma, P. Papini, A. V. Penacchioni, B. F. Rauch, S. B. Ricciarini, K. Sakai, T. Sakamoto, M. Sasaki, Y. Shimizu, A. Shiomi, R. Sparvoli, P. Spillantini, F. Stolzi, J. E. Suh, A. Sulaj, I. Takahashi, M. Takayanagi, M. Takita, T. Tamura, T. Terasawa, H. Tomida, S. Torii, Y. Tsunesada, Y. Uchihori, S. Ueno, E. Vannuccini, J. P. Wefel, K. Yamaoka, S. Yanagita, A. Yoshida, and K. Yoshida
Published: 2019
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35. The CALorimetric Electron Telescope (CALET) on the International Space Station: Results from the First Two Years On Orbit

Author: Y Asaoka, O Adriani, Yosui Akaike, Katsuaki Asano, M G Bagliesi, E Berti, G Bigongiari, W R Binns, S Bonechi, M Bongi, A Bruno, Paolo Brogi, J H Buckley, N Cannady, G Castellini, C Checchia, M L Cherry, G Collazuol, V Di Felice, K Ebisawa, Hideyuki Fuke, T Gregory Guzik, T Hams, N Hasebe, K Hibino, M Ichimura, K Ioka, W Ishizaki, M H Israel, K Kasahara, J Kataoka, R Kataoka, Y Katayose, C Kato, N Kawanaka, Y Kawakubo, K Kohri, H S Krawczynski, John F Krizmanic, T Lomtadze, Paolo Maestro, P S Marrocchesi, A M Messineo, John W Mitchell, S Miyake, Alexander A Moiseev, K Mori, M Mori, N Mori, H M Motz, K Munakata, H Murakami, Satoshi Nakahira, J Nishimura, Georgia Adair De Nolfo, James O Okuno, J F Ormes, S Ozawa, L Pacini, F Palma, V Pal’shin, P Papini, A V Penacchioni, B F Rauch, S B Ricciarini, Kenichi Sakai, Takuma Sakamoto, M Sasaki, A Shiomi, R Sparvoli, P Spillantini, F Stolzi, S Sugita, J E Suh, A Sulaj, I Takahashi, M Takayanagi, M Takita, Takumi Tamura, N Tateyama, T Terasawa, H Tomida, S Torii, Yoshiki Tsunesada, Y Uchihori, S Ueno, E Vannuccini, J P Wefel, K Yamaoka, S Yanagita, A Yoshida, K Yoshida, and Y Shimizu
Subjects: Physics Of Elementary Particles And Fields
Abstract: The CALorimetric Electron Telescope (CALET) is a high-energy astroparticle physics space experiment installed on the International Space Station (ISS), developed and operated by Japan in collaboration with Italy and the United States. The CALET mission goals include the investigation of possible nearby sources of high-energy electrons, of the details of galactic particle acceleration and propagation, and of potential signatures of dark matter. CALET measures the cosmic-ray electron+positron flux up to 20 TeV, gamma-rays up to 10 TeV, and nuclei with Z=1 to 40 up to 1,000 TeV for the more abundant elements during a long-term observation aboard the ISS. Starting science operation in mid-October 2015, CALET performed continuous observation without major interruption with close to 20 million triggered events over 10 GeV per month. Based on the data taken during the �rst two-years, we present an overview of CALET observations: 1) Electron+positron energy spectrum, 2) Nuclei analysis, 3) Gamma-ray observation including a characterization of on-orbit performance. Results of the electromagnetic counterpart search for LIGO/Virgo gravitational wave events are discussed as well.
Published: 2019
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36. Diabetic Kidney Disease

Author: Pichler, Raimund H., de Boer, Ian H., Diaz, Miguel F. Palma, Afkarian, Maryam, Lerma, Edgar V., editor, and Rosner, Mitchell, editor
Published: 2013
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37. Confirmatory factor analysis of 20-item toronto alexithymia scale in spanish patients with substance use disorder

Author: Raul F, Palma-Álvarez, Constanza, Daigre, Elena, Ros-Cucurull, Marta, Perea-Ortueta, Pedro, Serrano-Pérez, Germán, Ortega-Hernández, Josep A, Ramos-Quiroga, Lara, Grau-López, and Carlos, Roncero
Subjects: Psychometrics, Substance-Related Disorders, Humans, Affective Symptoms, Factor Analysis, Statistical
Abstract: Alexithymia is highly prevalent in patients with substance use disorders (SUDs) and has been implied in SUD pathogenesis and treatment outcomes. However, the psychometric properties of the most-used instrument for evaluating alexithymia (the 20-item Toronto Alexithymia Scale, TAS-20) have been scarcely studied in relation to SUD patients.
Published: 2022

38. Global economic burden of unmet surgical need for appendicitis

Author: Reuter, Anna, Rogge, Lisa, Monahan, Mark, Kachapila, Mwayi, Morton, Dion G, Davies, Justine, Vollmer, Sebastian, A A Essam, Abd Elkhalek Sallam, Abd Elrahman Elshafay, Abd El-Rahman Hegazy Khedr, Abdalla Gamal Saad, Abdalla Gharib, Abdalla Kenibar, Abdallah Salah Elsherbiny, Abdalrahman Adel, Abdelaziz Abdelaal, Abdelaziz Osman Abdelaziz Elhendawy, Abdelfatah Hussein, Abdelkader Belkouchi, Abdelmalek Hrora, Abdelrahman Adelshone, Abdelrahman Alkammash, Abdelrahman Assal, Abdelrahman Geuoshy, Abdelrahman Haroun, Abdelrahman Mohammed, Abdelrahman Sayed, Abdelrahman Soliman, Abdelrhman Essam Elnemr, Abdelrhman Kz Darwish, Abdelrhman Osama Elsebaaye, Abdul Khalique, Abdul Rehman Alvi, Abdul Wahid Anwar, Abdulaziz Altwijri, Abdullah Al-Mallah, Abdullah Almoflihi, Abdullah Altamimi, Abdullah Daqeeq, Abdullah Dwydar, Abdullah Gouda, Abdullah Hashim, Abdulmalik Altaf, Abdulmalik Huwait, Abdulrahman Abdel-Aty, Abdulrahman M Altwigry, Abdulrahman Sheshe, Abdulrasheed A Nasir, AbdulRazzaq Oluwagbemiga Lawal, Abdulshafi Khaled Abdrabou, Abdurrahaman Sheshe, Abdussemiu Abdurrazzaaq, Abebe Bekele Zerihun, Abeer Al-Shammari, Abeer El Gendy, Abeer Esam, Abeer Marey, Abhishek Mittal, Abiboye Yifieyeh, Abid Bin Mahamood, Abidemi Adesuyi, Abouelatta Khairy Aly, Abrar Nawawi, Adam Gyedu, Ade Waterman, Adedapo Osinowo, Adedeji Fatuga, Adel Albiety, Adel B Hassanein, Adel Denewar, Adeleke Adekoya, Ademola Adebanjo, Ademola Adeyeye, Ademola Popoola, Adesina Adedeji, Adesoji O Ademuyiwa, Adesoji Tade, Adewale Adeniyi, Adewale O Adisa, Adham Tarek, Adomas Ladukas, Adrian F Palma, Afifatun Hasanah, Afizah Salleh, Afnan Abdelfatah, Afnan Altamimi, Afnan Altamini, Agazi Fitsum, Agboola Taiwo, Ahamed Hassan, Ahed Ghaben, Ahmad Abdel Fattah, Ahmad Abdel Razaq Al Rafati, Ahmad Aboelkassem Ibrahem, Ahmad Aldalaq, Ahmad Ali, Ahmad Almallah, Ahmad Alrifaie, Ahmad Ashour, Ahmad Bakr, Ahmad Bani-Sadar, Ahmad Bin Adnan, Ahmad Elbatahgy, Ahmad Faraz, Ahmad Gudal, Ahmad Hasan, Ahmad Khaled Sabe, Ahmad Khoja, Ahmad Nashaat, Ahmad Qaissieh, Ahmad Sabe, Ahmad Saber Sleem, Ahmad Sakr, Ahmad Shalabi, Ahmad Uzair Qureshi, Ahmed Aamer, Ahmed Abd El Galeel, Ahmed Abd Elmoen Elhusseiny, Ahmed Abd Elsameea, Ahmed Abdelkareem, Ahmed Abdelmotaleb Ghazy, Ahmed Abo El Magd, Ahmed Abo Elazayem, Ahmed Adamu, Ahmed Adel, Ahmed Afandy, Ahmed Ahmed, Ahmed Alghamdi, Ahmed Ali, Ahmed Al-Khatib, Ahmed Altibi, Ahmed Alzahrani, Ahmed Ata, Ahmed Badr, Ahmed Dahy, Ahmed Diab, Ahmed El Kashash, Ahmed El Kholy, Ahmed Elgaili Khalid Musa, Ahmed Elgebaly, Ahmed Elkelany, Ahmed Elkholy, Ahmed El-Sehily, Ahmed Essam, Ahmed Fahiem, Ahmed Farag, Ahmed Fawzy, Ahmed Fouad, Ahmed Gad, Ahmed Ghanem, Ahmed Gheith, Ahmed Gomaa, Ahmed Hafez El-Badri Kotb, Ahmed Hammad, Ahmed Hassan, Ahmed Hossam Eldin Fouad Rida, Ahmed Ismail, Ahmed Karim, Ahmed Khyrallh, Ahmed Lasheen, Ahmed M Rashed, Ahmed Magdy, Ahmed Mahmoud Abdelraouf, Ahmed Menshawy, Ahmed Meshref, Ahmed Mohamed Afifi, Ahmed Mohamed Ibrahim, Ahmed Mohameden, Ahmed Mohammed, Ahmed Mokhtar, Ahmed Mosad, Ahmed Moustafa, Ahmed Moustafa Saeed, Ahmed Negida, Ahmed Rabeih Mohammed, Ahmed Rabie Mohamed, Ahmed Ragab Nayel, Ahmed Ragab Soliman, Ahmed Raslan, Ahmed Raza, Ahmed Refaat, Ahmed Rslan, Ahmed Sabry, Ahmed Sabry El-Hamouly, Ahmed Safwan Marey, Ahmed Saidbadr, Ahmed Sakr, Ahmed Samir, Ahmed Shahine, Ahmed Sheta, Ahmed Soliman, Ahmed Tammam, Ahmed Tarek Abdelbaset Hassan, Ahmed W Shamsedine, Ahmed Zaki, Ahmed Zaki Eldeeb, Ahmed Zohair, Ahmedali M Kandil, Ahmedglal Elnagar, Ahsan Zil-E-Ali, Aijaz Jabbar, Ailsa Claire Snaith, Ainhoa Costas-Chavarri, Aiste Austraite, Ajayesh Mistry, Akin Olaolorun, Akinlabi E Ajao, Al Faifi Jubran, Ala Shamasneh, Alaa Abouelnasr, Alaa Al-Buhaisi, Alaa Bowabsak, Alaa El Jamassi, Alaa Elazab, Alaa Elhadad, Alaa Fergany, Alaa Habeebullah, Alaa Hassan, Alaa Shabkah, Alaa Shaheen, Alaba Adesina, Alan Baird, Alan Grant, Alasdair Ball, Alban Cacurri, Albert Mohale Mphatsoe, Alberto Realis Luc, Alejandro Matheu, Alejandro Munera, Alemayehu Ginbo Bedada, Alessandro Favero, Alessio Maniscalco, Alexander Canta Calua, Alexander J Fowler, Alexandra Gerosa, Alexandre Horobjowsky, Alexandre Venancio De Sousa, Alexia Farrugia, Alexis Pierre Arnaud, Alfio Alessandro Russo, Alfredo Gulielmi, Ali Ababneh, Ali Abo El Dahab, Ali Amin Ahmed Ata, Ali Khan Niazi, Ali Kiasat, Ali Mohamed Hammad, Ali Zardab, Ali Zeynel Abidin Balkan, Aliaa Gamal Toeema, Aliaa Sadek, Aliaksandr Filatau, Aliang Latif, Alibeth Andres Baquero Suarez, Alice Faure, Alice Niragire, Alina Robledo-Rabanal, Aline Broch, Alireza Hasheminia, Alisdair Macdonald, Aliyu Ndajiwo, Allan Novak, Alphonse Zeta Mutabazi, Alvaro Enrique Mendoza Beleño, Alvin Ee Zhiun Cheah, Aly Abd Elrazek, Aly Nasr, Aly Sanad, Alyaa Halim Elgendy, Alyne Daltri Lazzarini Cury, Amal Ibrahim, Amandine Martin, Amani Althwainy, Amany Abouzahra, Amany Eldosouky Mohammed, Amar Kourdouli, Amel Hashish, Amerdip Birring, Amgad Al Meligy, Amina Abdelhamid, Aminah Hanum Haji Abdul Majid, Aminu Mohammad, Amir Ait Kaci, Amira Atef Omar, Amira Elsawy, Amira Hassan Bekhet, Amira Reda, Amjad Abu Qumbos, Amjad Elmashala, Ammar Gado, Amna Mamdouh Mohamed, Amna Mohamed, Amoudtha Rasendran, Amr Ahmed Saleh, Amr Fadel, Amr Hasan, Amr Hassaan, Amr Hossameldin, Amr Muhammad Elkorashy, Amr Tarek Hafez, Amreen Faruq, Amro Aglan, Ana Cecilia Manchego Bautista, Ana Lucia Contreras-Vergara, Ana Maria Sandoval Barrantes, Ana Vega Carreiro De Freitas, Ana Vega Freitas, Anam Rashid, Anan Rady Abdelazeam, Anand Kirishnan, Anass Majbar, Anastasia Bamicha, Anastasios Stefanopoulos, Anders Thorell, Andre Das, Andre Dubois, Andre L Mihaljevic, Andre Navarro, Andrea Allegri, Andrea Armellini, Andrea Belli, Andrea Bondurri, Andrea Echevarria Rosas Moran, Andrea Natili, Andrea Ruzzenente, Andrea Simioni, Andreass Haloho, Andrei Tanase, Andrej Kolosov, Andrejus Subocius, Andrew G N Robertson, Andrew Kirby, Andrew Mcguigan, Andrew Spina, Andrey Litvin, Andrius Burmistrovas, Andrius Strazdas, Andy Arenas, Aneel Bhangu, Anele Rudzenskaite, Angel David Pérez Rojas, Angela Dell, Angelica Genoveva Vergara Mejia, Angeline Charles, Angelo Antoniozzi, Angelo Benevento, Angelos Tselos, Angham Solaiman El-Ma'doul, Anjana Sreedharan, Ankur Bhatnagar, Ann Kjellin, Anna Lasek, Anna Maffioli, Anna Powell, Anna Rinaldi, Anna Watts, Annalisa Lo Conte, Annamaria Bigaran, Annelisse Ashton, Annisa Dewi Fitriana Mukin, Antanas Gulbinas, Antanas Zadoroznas, Anthonius Santoso Rulie, Anthony Ajiboye, Anthony Avoka, Anthony Chuk-Him Lai, Anthony Davor, Anthony Sander, Antje Oosterkamp, Antoinette Bediako-Bowan, Antonella La Brocca, Antônio Leal, Antonio Nocito, Antonio Ramos-De La Medina, Antonio Taddei, Anwar Atiyeh, Anyomih Theophilus Teddy Kojo, Aoife Driscoll, Apar Shah, Apostolos Vlachogiorgos, April Camilla Roslani, Aram Abdelhaq, Arazzelly Del Pilar Paucar, Arcangelo Picciariello, Areej Tarek, Arezo Kanani, Ari Leppäniemi, Arianna Birindelli, Arij Ibrahim, Arjun Nesaratnam, Arlindawati Suyadi, Armando José Román Velásquez, Arnaud Bonnard, Arnav Agarwal, Aroub Alkaaki, Arturas Vaicius, Arvin Khamajeet, Arvo Reinsoo, Arwa Abouzaid, Arwa Elfarargy, Arwa Ibrahim, Arwa Mohamed, Asaf Kedar, Asdaq Ahmed, Ased Ali, Aseel Alnusairat, Aseel Hamarshi, Aseel Musleh, Ash Prabhudesai, Ashraf A Maghrabi, Ashraf Morsi, Ashrarur Rahman Mitul, Asmaa Abdelgelil, Asmaa Abdel-Rahman Al-Aarag, Asmaa Rezq, Asmaa Salah, Aspasia Papailia, Assmaa Badwy, Astrid Leusink, Ata Khan, Ataa Ahmed, Athanasia Bamicha, Athar Eysa, Athirah Zulkifli, Atif Mahdi, Attia Attia, Attia Mohamed Attia, Audrey Clarissa, Audrius Dulskas, Audrius Parseliunas, Augusto Zani, Aung Kyaw Tun, Aurel Mironescu, Aurel Sandu Mironescu, Aurelien Scalabre, Aurora Mariani, Aurore Haffreingue, Aurore Thollot, Ausrine Usaityte, Austė Skardžiukaitė, Awais Raza, Aya Abdel Fatah Ibraheem, Aya Aboarab, Aya Adel Elsharkawy, Aya El-Sawy, Aya Elwaey, Aya Firwana, Aya Hagar, Aya Hammad, Aya Mohamed Fathy, Aya Reda, Aya Yehia Ata, Ayah Hamdan, Ayat Hassaan, Ayman And Taher, Ayman Elwan, Ayman Nabawi, Ayman Salman, Ayman Shwky, Ayokunle Ogunyemi, Azher Herebat, Azmina Verjee, Babajide Adenekan, Babatunde Odeyemi, Badr Eldin Adel, Badreldin Adel Tawfik, Bahar Busra Ozkan, Bakeer Mohamed, Bakhtiar Nighat, Bandar Albeladi, Bárbara Málaga, Barbara Mijuskovic, Barbara Pereira Silvestre, Basant Kumar, Basem Sieda, Bashir Bello, Basim Alghamdi, Basma Magdy, Basma Mahmoud, Basmah Alhassan, Bassant Mowafy, Beatrice Brunoni, Beatrix Weber, Belen Sanchez, Ben Thompson, Benoît Parmentier, Bernard Limoges, Bernard Van Duren, Bernhard Wolf, Bertrand Dousset, Besmir Grizhja, Bettina Lieske, Betty Maillot, Billal Mansour, Bjorn Frisk, Bogdan Diaconescu, Bogdan-Valeriu Martian, Boris Marinkovic, Brendan Skelly, Brian Cameron, Britta Dedekind, Bruno Noukpozounkou, Bryon Frankie Hon Khi Chong, Bylapudi Seshu Kumar, Caio Vinícius Barroso de Lima, Calogero Iacono, Cameron Fairfield, Camila Sanchez Samaniego, Camilla Cona, Camilo Lopez-Arevalo, Caoimhe Normile, Caranj Venugopal, Carla Cecilia Ramã Rez Cabrera, Carla Pierina García Torres, Carlo Corbellini, Carlos Alejandro Arroyo Basto, Carlos Iván Pérez Velásquez, Carlos Morales, Carlos Nsengiyumva, Carlos Paz Galvez, Carmen Capito, Carmen Fernández, Carmina Diaz-Zorrilla, Carolina Guzmán Dueñas, Carolina Oliveira Felipe, Caroline Clifford, Caroluce K Musyoka, Catherine A Shaw, Cathy Magee, Cecile Muller, Cecilia Costa, Cecilia Tolg, Cecilia Wredberg, Celeste Del Basso, Céline Grosos, Cesar Augusto Azmitia Mendizabal, Cesar Miranda, Cesar Razuri, Cezar Ciubotaru, Chali Chibuye, Challine Alexandre, Charing Cheuk Ling Szeto, Charles Dally, Charlotte Jane Mcintyre, Chaymae Benyaiche, Chean Leung Chong, Chee Siong Wong, Cheewei Gan, Chelise Currow, Chelsea Deane, Cheng Chun Goh, Cherry Koh, Cheryl Ou Yong, Chetan Khatri, Chi Chung Foo, Chi Ying Jacquelyn Fok, Chia Kong, Chiara Ceriani, Chimwemwe Kwatiwani, Chingwan Yip, Chintya Tedjaatmadja, Choon Seng Chong, Chouikh Taieb, Choy Ling Tan, Chris Bode, Chris Lee, Christel Leanne Almanon, Christian Hinojosa, Christian Lari Coompson, Christin Schoewe, Christina Neophytou, Christina P Major, Christina Panteli, Christine Mizzi, Christoforos Ferousis, Christopher Bode, Christos Agalianos, Christos Anthoulakis, Christos Barkolias, Christos Dervenis, Chu-Ann Chai, Chui Yee Wong, Ciara Fahy, Cicilia Viany Evajelista, Cirugia De Emergencia, Ciskje Zarb, Citra Dewi Mohd Ali, Claire Sharpin, Clara Milagros Herrera Puma, Clare M Rees, Clare Morgan, Claudia Reali, Claudio Arcudi, Claudio Fermani, Claudio Gabriel Fermani, Clemens Nawara, Clement Onuoha, Clodagh Mangan, Colleen Sampson, Collins Nwokoro, Colombani Jean-Francois, Constantinos Marinos, Cornelius Mukuzunga, Corrado Bottini, Craig Gouldthorpe, Crislee Elizabeth Lopez, Cristina Fernandes, Crystal Yern Nee Chow, Cutting Edge Manipal, Dale Vimalachandran, Dalia Alkhabbaz, Dalia Hemeda, Damien Brown, Damir Ljuhar, Dan L Deckelbaum, Dana Jaradat, Danelo Du Plessis, Daniel Ardian Soeselo, Daniel Cox, Daniel Dabessa, Daniel Estuardo Marroquín Rodríguez, Daniel Hamill, Daniel Nel, Daniel Youssef, Daniela Magri, Daniele Angelieri, Daniele Gui, Danilo Herrera Cruz, Danjuma Sale, Dansou Gaspard Gbessi, Dario Andreotti, Darius Kazanavicius, Darragh McCullagh, David Mcnish, David Merlini, David Monterroso Cohen, Davide De Boni, Davide Rossi, Dayang Nita Abdul Aziz, D C Grobler, Debora Schivo, Deborah Chiesa, Deimante Mikuckyte, Deividas Dragatas, Demi Gray, Diaa Eldin Abdelazeem Amin Elsorogy, Diaa Moustafa Elbendary Elsawahly, Diaaaldin Zahran, Diana Duarte Cadogan, Diana Sanchez, Dickson Bandoh, Diego Alonso Romani Pozo, Diego Antezana, Diego Coletta, Diego Romani, Diego Sasia, Dietmar Öfner, Dieudonne Duhoranenayo, Dimitri Aristotle Raptis, Dimitrios Balalis, Dimitrios K Manatakis, Dimitrios Karousos, Dimitrios Korkolis, Dimitrios Kyziridis, Dimitrios Lytras, Dimitrios Papageorgiou, Dimitrios Sfougaris, Dimitris-Christos Zachariades, Dina Al-Marakby, Dina Faizatur Rahmah, Dina Gamal, Dina Tarek, Dineshwary Periasammy, Diogo Vinicius Dos Santos, Dion Morton, Diya Mirghani, Djifid Morel Seto, D M Cocker, Dmitri A Raptis, Dmitri Nepogodiev, Dmitri Raptis, Doaa Emadeldin, Doaa Gamil, Doaa Hasan, Doaa Hasanain, Doaa Maher Abdelrouf, Domenica Pata, Domingos Mapasse, Dominic Charles Marshall, Donal B O'Connor, Donatas Danys, Donatas Venskutonis, Dorota Radkowiak, Doug Bowley, Dovilè Majauskyté, Dulan Irusha Samaraweera, Durvesh Lacthman Jethwani, Dush Iyer, Dushyant Iyer, Dzianis Khokha, Dzmitry Paulouski, Ebenezer Takyi Atkins, Echaieb Anis, Edgar Domini, Edilberto Temoche, Eduardo Huaman, Edvard Grisin, Edvinas Dainius, Efeson Thomas, Egle Preckailaite, Ehab Alnawam, Ehab Mamdouh, Eirik Kjus Aahlin, Eirini Kefalidi, Ekow Mensah, Elaine Borg, Eldaa Prisca Refianti Sutanto, Eleanor Marks, Elena Goldin, Elena Muzio, Elena Vendramin, Elena Zdanyte Sruogiene, Eleonora Ciccioli, Elio Jovine, Elisa Francone, Elisabeth Jensen, Elissa Rifhan Mohd Basir, Elizabeth Snyder, Ella Teasdale, Elliot Akoto, Elodie Gaignard, Elodie Haraux, Elsa Robert, Elsayed Ali, Elsayed Gamaly, Emad Abdallah, Emad Al-Dakka, Emad Ali Ahmed, Emad Aljohani, Emad Mohamed Saeed Taha, Eman Abd Al Raouf, Eman Abdelmageed, Eman Abuqwaider, Eman Adel Sayma, Eman Elwy, Eman Emara, Eman Hashad, Eman Ibrahim, Eman Magdy, Eman Magdy Hegazy, Eman Mahmoud Abdulhakeem, Eman Mohamed Ibrahim, Eman Mohamed Morshedy, Eman Nofal, Eman Rashad, Eman Yahya Mansor, Emanuel Barrios, Emanuele Rausa, Emeka Nwabuoku, Emilia De Luca, Emilie Eyssartier, Emilio Dijan, Emma Blower, Emma Jurdell, Emma Upchurch, Emmanuel Acquah, Emmanuel Akatibo, Emmanuel Barrios, Emmy Runigamugabo, Enas Alaloul, Enas Alqahtani, Enoch Dagoe, Enoch Tackie, Eriberto Farinella, Eric Ackom, Eric Kofi Appiah, Erick Samuel Florez Farfan, Erik Hervieux, Erik Schadde, Erika Vicario, Erikas Laugzemys, Ernest Yemalin Stephane Ahounou, Eslam Elbanby, Eslam Ezzat, Esraa Abd Elkhalek, Esraa Abdalmageed Kasem, Esraa Alm Eldeen, Esraa El-Gizawy, Esraa Elhalawany, Esraa El-Taher, Esraa Gamal, Esraa Ghanem, Esraa Kasem, Esraa Samir Elbanby, Esraay Zakaria, Ethar Hany, Etienne Courboin, Eu Xian Lee, Euan Macdonald, Eugene Niyirera, Eugenio Grasset, Eugenio Morandi, Eugenio Panieri, Eva Borin, Evangelos Voulgaris, Evelina Slapelyte, Evelina Woin, Ewan Macdermid, Ewen M Harrison, Eyad Khalifah, Ezio Veronese, Fabian Deichsel, Fabrizio Aquilino, Fahd Abdel Sabour, Faisal Idris, Faith Qi Hui Leong, Fanjandrainy Rasoaherinomenjanahary, Farah Mahmoud Ali, Farhana Iftekhar, Farrag Sayed, Fatai Balogun, Fatema Al Bastawis, Fatema Asi, Fathee Nada, Fathi Elzowawi, Fathia Abd El-Salam, Fathy Sroor, Fatima Baluch, Fatimah I Elgendy, Fatma Elkady, Faustin Ntirenganya, Fawzia Abdellatif Elsherif, Fawzy Mohamed, Fayez Elian Al Barrawi, Fazlin Noor, Federica Bianco, Federica Falaschi, Federico Coccolini, Fei Zheng, Felipe Zapata, Felix Alakaloko, Felix Lee, Feng Yih Chai, Ferdy Iskandar, Fernanda Altoe, Fernanda Frade, Fernande Djivoh, Fernando Espinoza, Fernando Fernandez-Bueno, Fernando Tale, Ferry Fitriya Ayu Andika, Fidelis Jacklyn Adella, Filippo Di Franco, Finaritra Casimir Fleur Prudence Rahantasoa, Fitjerald Henry, Fitriana Nur Rahmawati, Florence Dedey, Florian Primavesi, Florin-Mihail Iordache, Fong Yee Lam, Foteini Koumpa, Francesca Steccanella, Francesco Pata, Francesco Riente, Francesco Ruben Giardino, Francesco Selvaggi, Francis Abantanga, Francis Dossou, Francisco Fujii, Francisco Regalado, Francois-Coridon Helene, Françoise Schmitt, Frank Enoch Gyamfi, Frank Owusu, Fred Alexander Naranjo Aristizã Bal, Fred Hodonou, Frederick Du Toit, Frederique Sauvat, Fredrik Wogensen, Frehun Ayele Asele, Fridiz Saravia, Gabriel Pardo, Gabriela Elisa Nita, Gaetano Gallo, Gaetano Luglio, Gaetano Tessera, Galaleldin Abdelazim, Gamal Shimy, Gandau Naa Barnabas, Garba Samson, Gareth Irwin, Gehad El Ashal, Gehad Samir El Sayed, Gehad Tawfik, Gemma Humm, Genoveffa Balducci, George Christian Manrique Sila, George Ihediwa, George Manrique Sila, Georges Azzie, Georgette Marie Camilleri, Georgios Gemenetzis, Georgios Gkiokas, Georgios Karabelias, Georgios Kyrou, Georgios Tzikos, Gerardo Perrotta, Gerfried Teufelberger, Germain Ahlonsou, German Minguez, Geta Maharaj, Gezim Galiqi, Ghada Elhoseny, Ghada Saied Nagy, Ghiath Al Saied, Ghina Shamim Shamsi, Giacomo Nastri, Giacomo Pata, Gianfranco Cocorullo, Gianluca Curletti, Gianluca Pagano, Gianluca Pellino, Gianmaria Confalonieri, Gianpiero Gravante, Giedrius Lauzikas, Giles Dawnay, Gintaras Simutis, Giorgio Vasquez, Giovanni Landolfo, Giovanni Lazzari, Giovanni Luca Lamanna, Giovanni Pascale, Giovanni Pesenti, Giovanni Sgroi, Giridhar H Devadasar, Gisele Moreira, Giuliano Borda-Luque, Giuseppe Clerico, Giuseppe Rotunno, Giuseppe Salamone, Giuseppe Sammarco, Gokhan Lap, Greg Padmore, Gregorio Tugnoli, Gregory Kouraklis, Greta Mclachlan, Greta Wood, Greta Žiubrytė, Guillaume Podevin, Guillermo Sanchez Rosenberg, Guo Liang Yong, Gurdeep Singh Mannu, Gurpreet Singh Banipal, Gustavo Miguel Machain Vega, Gustavo Peixoto Soares Miguel, Gustavo Pereira Fraga, Gustavo Recinos, Gustavo Rodolfo Pertersen Servin, Haaris A Shiwani, Hadeel Al-Farram, Hafiz Hakim, Hagar Zidan, Hager Abdul Aziz Amin, Hager Abdulaziz, Hager Ahmed El-Badawy, Hager Elwakil, Hager Tolba, Hagir Zain Elabdin, Haidar Hajeh, Hala Ahmed, Hala Saad, Halima Aliyu, Hamdi Ebdewi, Hamza Asumah, Hamza Waleed, Hanan Adel Saad, Haney Youssef, Hani Natalie, Hanna Royson, Hannah Anderson-Knight, Hannah Burns, Hannah S Thomas, Hans-Ivar Pahlsson, Harish Neelamraju Lakshmi, Harriet Jordan, Hasan Ismael Ibraheem, Hasan Ismael Ibraheem Al-Hameedi, Hasbi Maulana Arsyad, Hasnain Abbas Dharamshi, Hassan Ali Mostafa, Hatem El-Sheemy, Haya Tahboub, Hayam Ahmed, Hayden Kretzmann, Hayssam Rashwan, Haytham Abudeeb, Hazem Khaled, Hazmi Dwinanda Nurqistan, Heather Bougard, Heba Baraka, Heba Gamal, Heba Shaker, Hector Shibao Miyasato, Helen Mohan, Helen Woodward, Helena Franco, Helene Francois-Coridon, Helmut Alfredo Segovia Lohse, Hend Adel Gawad Shakshouk, Hend Kandil, Hend Mahmoud, Henri Kotobi, Henry Mendel, Henry Nnaj, Herlin Karismaningtyas, Herman Cruz, Hesham Magdy, Hesham Mohammed Bakry, Hian Ee Heng, Hildur Thorarinsdottir, Hisham Safa, Hisham Samih, Hogea Mircea, Hong Kong Sar, Hong Yee Wong, Hoong-Yin Chong, Hope Edem Kofi Kordorwu, Hope Glover-Addy, Horacio Paredes Decoud, Hosni Khairy Salem, Hossam Dawoud, Hossam Elfeki, Hossam Emadeldin, Houda Bachri, Hunain Shiwani, Hussein Ali, Hussein El-Kashef, Hussein Mohammed, Hussien Ahmed, Iason-Antonios Papaskarlatos, Ibrahem Abdelmotaleb, Ibrahim AbdelFattah, Ibrahim Alhabli, Ibrahim Al-Slaibi, Ibrahim AlYoussef, Ibrahim Elzayat, Ibrahim Elzayyat, Ibrahim N Alomar, Ibrahim Rakha, Ibrahim Raza, Ida Björklund, Idelso Vasquez, Ignas Rakita, Ihab Hassan, Ihdaa Adawi, Iloba Njokanma, Iman Elkadsh, Immacolata Iannone, Ingemar Havemann, Ioannis Kyriazanos, Ioannis Patoulias, Ioannis Valioulis, Ionasc Dan, Ionut Negoi, Ionut-Bogdan Diaconescu, Irene Montes, Irene Ortega-Vazquez, Isaac Amole, Isaac Bertuello, Isaac Hanley, Isam Bsisu, Islam Magdy El Sayed, Ismael Isaac Zelada Alvarez, Ismail Lawani, Israa Abdullah Aziz Al-Azraqi, Israa Adel, Israa Awad, Israa Qawasmi, Ivan Mendoza Restrepo, J Edward Fitzgerald, Jack Almy, Jacqueline Sheehan, Jaime Andres Montoya Botero, Jaime Herrera-Matta, Jakeline Restrepo, Jakov Mihanovic, James Adeniran, James Brown, James Davies, James Giles, James Glasbey, James Olivier, James Pape, James Richards, James Wheeler, James Yang, Jamie Shah, Janet Pagnozzi, Jannin Salcedo, Jasim Amin, Jason Brown, Javier Pastora, Javier Rosales, Jazmin Coronel, Jean Bréaud, Jean De La Croix Allen Ingabire, Jean-Baptiste Marret, Jean-Francois Colombani, Jean-François Lecompte, Jeffrey Dalli, Jehad Hassan Youssif, Jehad Meqbil, Jemina Onimowo, Jen Cornick, Jenifa Jeyakumar, Jennifer Nowers, Jennifer Rickard, Jennifer Skehan, Jerry Makama, Jesse Ron Swire Ting, Jessica Juliana Tan, Jessica Patricia Gonzales Stuva, Jessica Roth, Jessica Souza Luiz, Jia Hao Law, Jia Yng Siaw, Jian Er Saw, Jibran Abbasy, Jiheon Song, Jimy Harold Jara Quezada, Joachim Amoako, Joachim Wiborg, Joanna Swann, Jo-Anne Carreira, Joanne Edwards, Joe Vincent, Joel Kin Tan, Joe-Nat Clegg-Lamptey, Johanna Joosten, Johanna Nyberg, Johannes Kurt Schultz, Johannes Wiik Larsen, John Bondin, John F Camilleri-Brennan, John Jemuel V Mora, John Lee Y Allen, John Whitaker, Jolanta Gribauskaite, Jon Arne Søreide, Jon Kristian Narvestad, Jonathan Ajah, Jonathan Dakubo, Jonathan Heath, Jonathan R L Wild, Jonny Setiawan, Jorge Armando Chungui Bravo, Jorge Torres Cardozo, Jose Aguilar-Jimenez, Jose Andres Garcia-Marin, Jose Antonio Cabala Chiong, Jose Costa-Maia, José Hamasaki, José Luis Hamasaki Hamaguchi, Jose Luis Rodicio, Jose María Vergara Celis, José René Arévalo Azmitia, Joselyn Ye, Joseph Awuku-Asabre, Josephine Psaila, Joshua Luck, Joshua Michael Clements, Joyeta Razzaque, Juan Camilo Correa, Juan Carpio, Juan Gouws, Juan Jaime Herrera Matta, Juan Manuel Carmona, Juan Marcelo Delgado, Juana Kabba, Jubran J Al-Faifi, Julia Guasti Pinto Vianna, Julian Camilleri-Brennan, Juliana Menegussi, Julien Leroux, Julien Rod, Juliette Hascoet, Julio Jimenez, Junyeong Oh, Juozas Kutkevicius, Justas Kuliavas, Justas Žilinskas, Justin Chak Yiu Lam, Justus Lando, Ka Hin Gabriel Li, Ka Wai Leung, Kai Yin Lee, Kalangu Kabongo, Kalitha Pinnagoda, Kalon Hewage, Kamau Kinandu, Kamran Faisal Bhopal, Kandasami Palayan, Kareem Dabbour, Kareem Elshaer, Karen Bailey, Karim Hilal, Karl Bonavia, Karolis Lagunavicius, Karolis Varkalys, Kate Cross, Kate Yu-Ching Chang, Katharina Beate Reinisch, Katharine Whitehurst, Katherine Gash, Kathryn Chu, Kathryn Lee, Katie Connor, Katrin Gudlaugsdottir, Kaustuv Das, Kazeem Atobatele, K C Janardha, Kean Leong Koay, Keat-Seong Poh, Keiran David Clement, Keith Sammut, Keith Say Kwang Tan, Kenneth Aaniana, Kenneth Johnson, Kenneth Mealy, Kenneth Thorsen, Kenny Turpo Espinoza, Kent Pluke, Kestutis Strupas, Kevin C Conlon, Kevin Turpo Espinoza, Khaled Abozeid, Khaled Alhady, Khaled Aljboor, Khaled Dawood, Khaled Hesham Elbisomy, Khaled Ibrahim, Khaled Khattab, Khaled Naser El Deen, Khalid Mahmud, Khalid Qurie, Khalid Salah El-Dien, Khalil Abdul Bassit, Khaoula Boukhal, Khlood Ashour, Kholod Tarek Lasheen, Kholoud Abdelbadeai, Khurram Khan, Khuzaimah Zahid Syibrah, Kieran Atkinson, Kieran Ka Kei Li, Kirsten Lafferty, Kjetil Søreide, Knut Magne Augestad, Kolonia Konstantina, Konstantinos Farmakis, Konstantinos Gasteratos, Kornelija Maceviciute, Kpèmahouton René Keke, Kresimir Zamarin, Kristian Styles, Kristijonas Jasaitis, Kristijonas Jokubonis, Kristina Cassar, Kuet Jun Chung, Kuhaendran Gunaseelan, Kuok Chung Lee, Kurt Carabott, Kwabena Agbedinu, Kwaku Boakye-Yiadom, Kwame Maison, Kwasi Asare-Bediako, Kwasi Kusi, Kyaw Phyo Aung, Kylie Joan-Yi Szeto, Kyriakos Psarianos, Laimonas Uščinas, Lalith Asanka Jayasooriya Jayasooriya Arachchige, Lana Abusalem, Larissa Ines Páez Lopez, Lau Wen Liang Joel, Laura Gavagna, Laura Koskenvuo, Laura Lorenzon, Laura Luque, Laurent Fourcade, Lawal Abdullahi, Lawani Ismaïl, Lawrence Bongani Khulu, Layza-Alejandra Mercado Rodriguez, Lee Shi Yeo, Leif Israelsson, Lemuel Davies Bray, Lenin Peña, Leo Licari, Leonardo Solaini, Li Jing Yeang, Liam Henderson, Liam Richardson, Liana Roodt, Lillian Reza, Linas Urbanavicius, Linas Venclauskas, Linda Alvi Madrid Barrientos, Linda Andersson, Ling Wilson, Linn Nymo, Linnea Mauro, Liviu Iuliu Muntean, Liviu Muntean, Ljiljana Jeremic, Lofty-John Anyanwu, Lopna Ahmed Mohamed Ahmed, Lorena Fuentes-Rivera, Lorena Rodriguez, Lorena Solar García, Lorraine Sproule, Lotfy Eldamaty, Luai Jamal, Luana Ayres Da Silva, Lubna Sabeeh, Luc Hervé Samison, Luca Ansaloni, Luca Bortolasi, Luca Turati, Lucia Duinhouwer, Lucian Corneliu Vida, Lucile Fievet, Lucio Selvaggi, Ludwing Alexander Zeta Solis, Luen Shaun Chew, Luigi Bonavina, Luigi Bucci, Luigi Maria Cloro, Luis Alberto Valente Laufer, Luis Barneo, Luis Joaquín García Florez, Luis M Helguero-Santin, Luis Miguel Alvarez Barreda, Luis Tale, Luisa Giavarini, Luiz Carlos Barros De Castro Segundo, Luiza Sarmento Tatagiba, Lukas Eisner, Lusi Padma Sulistianingsih Mata, Maarten Vermaas, Mabel Amoako-Boateng, Maciej Walędziak, Madan Jha, Madelaine Gimzewska, Mads Gran, Maeve O'neill, Magdalini Mitroudi, Magnus Boijsen, Maha Al-Faqawi, Maha Elmasry, Maha Gamal Mohamad Hamad, Maha Nasr, Mahadevan Deva Tata, Mahitab Essam, Mahitab Morsy Farahat, Mahmoud A Elnajjar, Mahmoud Abdelshafy, Mahmoud Abdelshakour, Mahmoud Abdulgawad, Mahmoud Ahmed Fathi Abozyed, Mahmoud Alrahawy, Mahmoud Amreia, Mahmoud Badawy, Mahmoud Eldafrawy, Mahmoud Elfiky, Mahmoud Elkhadragy Maher, Mahmoud Elkhadrawi, Mahmoud Elsayed Moghazy, Mahmoud Gomah, Mahmoud M Saad, Mahmoud Mohamed Metwally, Mahmoud Morsi, Mahmoud Saad, Mahmoud Saami, Mahmoud Salama, Mahmoud Salma, Mahmoud Shalaby, Mahmoud Warda, Mahmoud Zakaria, Mahmut Arif Yuksek, Mahnoor Javaid, Mahnuma Mahfuz Estee, Mai Ebidy, Mai Mohamed Ebidy, Mai Salama, Maíra Cassa Careta, Maja Marcus, Majd Dabboor, Majed Aboelella, Makafui Dayie, Makki Elsayed, Malcolm Falzon, Maleeha Hassan, Malin Sund, Man Fung Leung, Man Hon Andrew Yeung, Manar Abd-Elmawla, Manar Saeed, Mantas Drungilas, Mantas Jokubauskas, Mantas Vilčinskas, Manuel Francisco Roxas, Manuel Hache-Marliere, Manuel Lopez, Manuel Rodriguez Castro, Manuela Mendez, Manzoor Dar, Maram Abu-Toyour, Maram Salah, Marcelo O Higgins Roche, Marco Catani, Marco Maria Pascale, Marco Migliore, Mardelangel Zapata Ponze De Leon, Margaret O'Shea, Margarita Montrimaite, Margherita Notarnicola, Margub Hussain, Maria Clara Mendoza Arango, Maria Giovanna Grella, Maria Hjertberg, Maria Isabel Villegas Lanau, Maria Jesusa B Maño, Maria Lorena Aguilera, Maria Marta Modolo, Maria Mayasari, Maria Novella Ringressi, Maria Soledad Gonzales Montejo, Maria Soledad Merlo, Maria Utter, María Valcarcel-Saldaña, Maria-Lorena Aguilera-Arevalo, Mariam Darweesh, Mariam O Gad, Mariam Saad Aboul-Naga, Mariano Cesare Giglio, Mariastella Malavenda, Marie Carmela Lapitan, Marie Dione Parreno-Sacdalan, Marie Paul, Mariette Renaux-Petel, Marija Agius, Marilia Del Carmen Escalante Salas, Marilla Dickfos, Marina Luiza Pimenta, Mario Contreras Urquizu, Mario Corbellino, Mário Jacobe, Mario Lopez, Mario Pasini, Mario Trompetto, Marisa Leal, Marisol Manriquez-Reyes, Mariuca Popa, Mark Ian Hampton, Mark Sykes, Mark Wagener, Markus Zuber, Marte Bliksøen, Martha Glynn, Martin Jarmin, Martin Kyereh, Martina Perino, Martina Yusuf Shawky, Martinique Vella-Baldacchino, Marvin Vargas, Marwa Altarayra, Marwa Elashmawy, Marwa Elshobary, Marwa Hamdan, Marwa Sayed, Marwan Abubakr, Marwan Fahim, Marwan Shawki, Maryam Ali Khan, Maryna Shubianok, Mashael Al-Mousa, Masood Alghamdi, Masood Jawaid, Massiell Machaca, Massimiliano Dal Canto, Massimo Coletti, Matas Pažuskis, Matei Bratu, Matei Razvan Bratu, Mateusz Rubinkiewicz, Matteo Papandrea, Matteo Ripa, Mattew Ekow, Matthew Baldacchino, Matthew Billy, Matthew Young-Han Kim, Matthieu Peycelon, Matti Tolonen, Maureen Bezzina, Maurizio Foco, Mawaddah Alrajraji, Max Dénakpo, Max Rath, Mayaba Maimbo, Mazed Mohamed, Mazen Hassanain, Megan Turner, Mehmet Ali Yavuz, Mehmet Gumar, Mehmet Uluşahin, Melanie Castro Mollo, Melanie Zapata Ponze De Leon, Menatalla Salem, Mengistu Worku, Menna Tallah Ramadan, Mennaallah Hafez, Mennat-Allah Mustafa, Menold Archee P Redota, Meran Allam, Meric Mericliler, Merna Mostafa, Meryem Abbouch, Metwally Aboraya, Michael Amoah, Michael Cox, Michael Edye, Michael Gillespie, Michael Hanrahan, Michael Livingston, Michael Puttick, Michael Stoddart, Michael Van Niekerk, Michael Walsh, Michael Wilson, Michail Kontos, Michail Margaritis, Michał Janik, Micheal Ohene-Yeboah, Michela Monteleone, Michele Carlucci, Michele Sacco, Michelle Mccarthy, Midhun Mohan, Miguel Angel Paludi, Miguel Siguantay, Mihael Radic, Mihaela Vartic, Miklosh Bala, Milaksh Kumar Nirumal, Milan Radojkovic, Milica Nestorovic, Millika Ghetia, Mindaugas Kiudelis, Mircea Beuran, Mircea Hogea, Mirko Mangiapane, Mitchelle Solange De Fã Tima Linares Delgado, Moayad Othman, Mobolaji Oludara, Modise Zacharia Koto, Mohamad Baheeg, Mohamad Bakhaidar, Mohamad Jeffrey Bin Ismail, Mohamed A Abdelaziz, Mohamed A Amer, Mohamed A Baky Fahmy, Mohamed Abbas, Mohamed Abd El Slam, Mohamed Abdelaty, Mohamed Abdelaty Mohamed, Mohamed Abdelkhalek, Mohamed Abdelraheim, Mohamed Abozaid, Mohamed Abozed Abdullah, Mohamed Abuseif, Mohamed Adel Badenjki, Mohamed Ali Ghonaim, Mohamed Ali Mahmoud, Mohamed Ameen, Mohamed Ammar, Mohamed Asal, Mohamed Awad Elkarim Hamad Mohamed, Mohamed Dablouk, Mohamed El Halawany, Mohamed Elazoul, Mohamed Elbermawy, Mohamed Elfil, Mohamed Elsehimy, Mohamed Elzayat, Mohamed Etman, Mohamed F Zalabia, Mohamed Fares, Mohamed Fawzy Mahrous Badr, Mohamed Fouad Hamed, Mohamed Gadelkarim, Mohamed Ghoneem, Mohamed Gulamhussein, Mohamed Hafez, Mohamed Hashish, Mohamed Hassab Alnaby, Mohamed Husseini, Mohamed Ibrahim, Mohamed Ismail, Mohamed Karkeet, Mohamed Kelany, Mohamed Mabrouk, Mohamed Magdy, Mohamed Mahmoud, Mohamed Moamen Mohamed, Mohamed Moaty, Mohamed Mostafa, Mohamed Mustafa, Mohamed Nashat, Mohamed Nazir, Mohamed Reda Loaloa, Mohamed Rezal Abdul Aziz, Mohamed Sabry Ammar, Mohamed Salah, Mohamed Salah Elhelbawy, Mohamed Seisa, Mohamed Shaalan, Mohamed Sleem, Mohamed Sobhi Jabal, Mohamed Youssef, Mohamed Zidan, Mohamedraed Elshami, Mohammad Abdulkhalek Habeeb, Mohammad Aboraya, Mohammad Adawi, Mohammad Alherz, Mohammad Aliyu, Mohammad Elsayed Omar, Mohammad Ghannam, Mohammad Ghassan Alwafai, Mohammad Mohsin Arshad, Mohammad Rashid, Mohammadasim Amjad, Mohammed Alamoudi, Mohammed Alhendy, Mohammed AlRowais, Mohammed Alsaggaf, Mohammed Alzahrani, Mohammed Bukari, Mohammed Deputy, Mohammed Elgheriany, Mohammed Elsayed, Mohammed Elshaar, Mohammed Elsiddig, Mohammed Firdouse, Mohammed G Azizeldine, Mohammed Hanafy, Mohammed Ismail, Mohammed Kamal Ismail, Mohammed Mousa, Mohammed Mousa Salem, Mohammed Mustafa Hassan Mohammed, Mohammed Mustafa Mohammed, Mohammed Najjar, Mohammed Nasr, Mohammed Osman, Mohammed Osman Dablouk, Mohammed Saeed, Mohammed Saleh A Alghamdi, Mohammed Ubaid Alsaggaf, Mohammed Yahia Mohamed Aly, Mohannad Aledrisy, Mojolaoluwa Olugbemi, Mona Hamdy Madkor, Mona Hosh, Mona Rashad, Monica Bassem, Monique Moron Munhoz, Monty Khajanchi, Morgan Haines, Morvarid Ashtari, Mostada Samy, Mostafa Abdelkader, Mostafa Ahmed Bahaa Eldin, Mostafa Allam, Mostafa Gemeah, Mostafa Mahmoud Eid, Mostafa Qenawy, Mostafa Samy, Mostafa Seif, Mostafa Shalaby, Mousa Mustafa, Moustafa Ibrahim Mahmoud, Moustafa R Aboelsoud, Msafiri Kimaro, Muayad Ahmed Alfarsi, Muhamed M H Farhan-Alanie, Muhammad Adil, Muhammad Alkelani, Muhammad Amsyar Auni Lokman, Muhammad Bin Hasnan, Muhammad Daniyan, Muhammad El-Saied Ahmad Muhammad Gohar, Muhammad Fathi Waleed Omar, Muhammad Habib Ibrahim, Muhammad Mohsin Furqan, Muhammad Rashid Minhas Qadir, Muhammad Saqlain, Muhammad Shawqi, Muhammad Talha Butt, Muhammad Taqiyuddin Yahaya, Muhammad Waqar, Muhammed Masood Riaz, Muhammed Talaat, Muhtarima Haque, Muna Rommaneh, Murad Aljiffry, Murat Karakahya, Musah Yakubu, Muslimat Alada, Mustafa Farhad, Mustafa Mohammed Taher, Muthukumaran Rangarajan, Muwaffaq Mezeil Telfah, Myint Tun, Myranda Attard, Nada Ahmed Reda Elsayed, Nada El-Sagheer, Nada Elzahed, Nada Mohamed Bekhet, Nader Abd El Hamid, Nadia Khalid Abd El-Latif, Nadia Ortiz, Nadin Elsayed, Nadya Johanna, Nahilia Carrasco, Najwa Nadeem, Naomi J Wright, Napoleon Mendez, Narimantas E Samalavicius, Nashat Ghandora, Nasir Bustangi, Natale Di Martino, Natalie Blencowe, Natalie Redgrave, Nathalie Botto, Nathania Sutandi, Nawal Sadig, Nazmie Kariem, Nebil Behar, Nebiyou Seyoum Abebe, Nebyou Seyoum, Nebyou Seyoum Abebe, Neel Gobin, Neel Limaye, Neerav Aruldas, Nehal Yosri Elsayed Abdel-Wahab, Neil Smart, Nelson Manuel Urbina Rojas, Nelson Msiska, Nerijus Kaselis, Nermeen Soubhy El-Shahat, Nermin M Badwi, Nermin Mohamed Badwi, Nesma Elfouly, Nicholas Phillips, Nichole Starr, Nicola Chetta, Nicola Zanini, Nicolas Henric, Nicole D'aguzan, Nicole Grech, Nicoleta Panait, Nicoletta Leone, Nicolò Falco, Nidhi Gyanchandani, Nigel J Hall, Nihaal Shaikh, Niiarmah Adu-Aryee, Nik Azim Nik Abdullah, Nik Ritza Kosai, Nikica Pezelj, Nikki Green, Nikolaos Gouvas, Nikolaos Ivros, Nikolaos Mitroudis, Nikolaos Nikoloudis, Nikolaos Zampitis, Nithya Niranjan, Niveshni Maistry, Noha Abdullah, Noha Abdullah Soliman, Noha Maraie, Noha Wael, Nohad Osman, Noman Shahzad, Nora Abdul Aziz, Norah Al Subaie, Noran Abdel-Hameed, Noran Halim El Gendy, Norbert Uzabumwana, Norberto Herrera, Norma Depalma, Nosisa Sishuba, Nouf Akeel, Noura A Attallah, Nourhan Adam, Nourhan Anwar, Nourhan Elsabbagh, Nourhan Medhat Elhadary, Nourhan Mesbah, Nourhan Semeda, Nourhan Soliman, Novia Adhitama, Nowrin F Aman, Nuno Muralha, Nur Zulaika Riswan, Nurlaila Ayu Purwaningsih, Nyawira Ngayu, Octavio Garaycochea, Oday Halhouli, Ogechukwu Taiwo, Ola Sherief Abd El Hameed, Olabisi Osagie, Olabode Oshodi, Olajide Abiola, Olalekan Ajai, Oliver Warren, Oliver Ziff, Olivier Abbo, Olivier Azzis, Olivier Rosello, Olubukola Faturoti, Olufemi Habeeb, Olumide Elebute, Oluseyi Ogunsua, Oluwaseyi Adebola, Oluwatomi Odutola, Omar Abdelkader, Omar Abdulbagi, Omar Aguilera, Omar Alahmady, Omar Arafa, Omar Ghoneim, Omar Hesham, Omar Mattar, Omar Moussa, Omar Osman, Omar Salah, Omar Saleh, Omnia Aboelmagd, Omnia Mosalum, Omobolaji O Ayandipo, Omolara Faboya, Omolara Williams, Opeoluwa Adesanya, Orestis Ioannidis, Osaid H Alser, Osama Algohary, Osama Mohamed, Osama Mohamed Salah, Osama Mokhtar Mohamed Hassan, Osama Saadeldeen Ebrahim, Osama Seifelnasr, Osman Imoro, Ossama Al-Obaedi, Otto Coyoy-Gaitan, Ourdia Bouali, Owusu Emmanuel Abem, Oyediran Kehinde Timothy, Oyindamola Oshati, Pablo Ramazzini, Pål Aksel Næss, Pamphile A Assouto, Panchali Sarmah, Pandi Eduard, Panu Mentula, Paola Salusso, Paola Violi, Paolino De Marco, Paolo Aonzo, Paolo Silvani, Paolo Ubiali, Patrizio Mao, Paul Kielty, Paul Sutton, Paul Ugalde, Paul Witherspoon, Paul Wondoh, Pauline Gastaldi, Paulius Karumnas, Paulius Kondrotas, Paulo Alves Bezerra Morais, Pedro Angel Toribio Orbegozo, Peep Talving, Pei Ying Koh, Per Weber, Per-Olof Lundgren, Peter Deutschmann, Peter Labib, Peter Wiel Monrad-Hansen, Petras Višinskas, Phebe Anggita Gultom, Philip Alexander, Philip Choi, Philip Mshelbwala, Philip Taah Amoako, Philippe Buisson, Phoebe De Bono, Phumudzo Ndwambi, Pier Paolo Grandinetti, Piergiorgio Danelli, Pierpaolo Sileri, Pietra Ligure, Pietro Mingrone, Pigeneswaren Yoganathan, Piotr Major, Poddevin Francois, Povilas Ignatavicius, Povilas Mazrimas, Prasad Pitigala Arachchi, Pratik Jain, Prince Kwakyeafriyie, Prisca A L Har, Pui Xin Chin, Puneet Malik, Puyearashid Nashidengo, Qinyang Liu, Quentin Alimi, Quentin Ballouhey, Quinn Ellison, R Goh Ern Tze, Rachel 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Thabet, Waleed, Adham, Walid, Forno, Walter, Ruiz Panez, Walter, Nurul 'Ain Wan Mohd Nasir, Wan, Senanayake Mudiyanselage Kithsiri Janakantha Senanayake, Wanigasekara, Hamsho, Ward, Dar, Wasim, Alhazmi, Wedyan, Guo, Wei, Ho, Weiguang, Dao, Weihei, Leslie Messa Aguilar, Wendy, Goh, Wennweoi, Saditya Jeo, Wifanto, Pino, Wilfredo, Appeadu-Mensah, William, Beasley, William, Bonney, William, Hutch, William, J Lossius, William, Milligan, William, Alcca Ticona, Willy, Sum Li, Wing, Chachulski, Witold, Delforge, Xavier, Rodriguez, Xianelle, Low, Xinwei, Wei Chan, Xue, Theng Neo, Ya, Imorou Souaibou, Yacoubou, Ukwenya, Yahaya, Salama, Yahya, Rajjoub, Yaseen, Ibrahim, Yasmein, Abd-Elrasoul, Yasmin, Elfouly, Yasmin, Hegazy, Yasmin, Soliman, Yasmin, Abd El Salam, Yasser, Wen Tan, Yee, Zakaria, Yehia, Reddy, Yella, Koon Tan, Yi, Ting Mok, Yi, Jeng Cheong, Yih, Yee Gan, Yiing, Der, Yishan, Praveen Mogan, Yogendra, Allam, Yomna, Hosny Asar, Yomna, Yong Tew, Yong, Abuowda, Yousef, El Shoura, Yousra, Esthefany Alejos Bermúdez, Ysabel, Cengiz, Yücel, Hong Eric Cheung, Yuk, Altinel, Yuksel, Kok Ng, Yung, Macchitella, Yuri, Aigrain, Yve, Mikwar, Zaher, Jaffry, Zahra, Ali Khan, Zain, Iftikhar, Zainab, M Elsayed, Zaynab, Zhang, Zhongtao, Hao Sam, Zi, Urniežius, Zigmanta, Dambrauskas, Zilvina, Bentounsi, Zineb, Tverskis, Zygimantas, Reuter A., Rogge L., Monahan M., Kachapila M., Morton D.G., Davies J., Vollmer S., Essam A.A., Sallam A.E., Elshafay A.E., Khedr A.E.-R.H., Saad A.G., Gharib A., Kenibar A., Elsherbiny A.S., Adel A., Abdelaal A., Elhendawy A.O.A., Hussein A., Belkouchi A., Hrora A., Adelshone A., Alkammash A., Assal A., Geuoshy A., Haroun A., Mohammed A., Sayed A., Soliman A., Elnemr A.E., Darwish A.K.Z., Elsebaaye A.O., Khalique A., Alvi A.R., Anwar A.W., Altwijri A., Al-Mallah A., Almoflihi A., Altamimi A., Daqeeq A., Dwydar A., Gouda A., Hashim A., Altaf A., Huwait A., Abdel-Aty A., Altwigry A.M., Sheshe A., Nasir A.A., Lawal A.O., Abdrabou A.K., Abdurrazzaaq A., Zerihun A.B., Al-Shammari A., Gendy A.E., Esam A., Marey A., Mittal A., Yifieyeh A., Bin Mahamood A., Adesuyi A., Aly A.K., Nawawi A., Gyedu A., Waterman A., Osinowo A., Fatuga A., Albiety A., Hassanein A.B., Denewar A., Adekoya A., Adebanjo A., Adeyeye A., Popoola A., Adedeji A., Ademuyiwa A.O., Tade A., Adeniyi A., Adisa A.O., Tarek A., Ladukas A., Palma A.F., Hasanah A., Salleh A., Abdelfatah A., Altamini A., Fitsum A., Taiwo A., Hassan A., Ghaben A., Fattah A.A., Al Rafati A.A.R., Ibrahem A.A., Aldalaq A., Ali A., Almallah A., Alrifaie A., Ashour A., Bakr A., Bani-Sadar A., Bin Adnan A., Elbatahgy A., Faraz A., Gudal A., Hasan A., Sabe A.K., Khoja A., Nashaat A., Qaissieh A., Sabe A., Sleem A.S., Sakr A., Shalabi A., Qureshi A.U., Aamer A., El Galeel A.A., Elhusseiny A.A.E., Elsameea A.A., Abdelkareem A., Ghazy A.A., El Magd A.A., Elazayem A.A., Adamu A., Afandy A., Ahmed A., Alghamdi A., Al-Khatib A., Altibi A., Alzahrani A., Ata A., Badr A., Dahy A., Diab A., Kashash A.E., Kholy A.E., Musa A.E.K., Elgebaly A., Elkelany A., Elkholy A., El-Sehily A., Essam A., Fahiem A., Farag A., Fawzy A., Fouad A., Gad A., Ghanem A., Gheith A., Gomaa A., El-Badri Kotb A.H., Hammad A., Rida A.H.E.F., Ismail A., Karim A., Khyrallh A., Lasheen A., Rashed A.M., Magdy A., Abdelraouf A.M., Menshawy A., Meshref A., Afifi A.M., Ibrahim A.M., Mohameden A., Mokhtar A., Mosad A., Moustafa A., Saeed A.M., Negida A., Mohammed A.R., Mohamed A.R., Nayel A.R., Soliman A.R., Raslan A., Raza A., Refaat A., Rslan A., Sabry A., El-Hamouly A.S., Marey A.S., Saidbadr A., Samir A., Shahine A., Sheta A., Tammam A., Hassan A.T.A., Shamsedine A.W., Zaki A., Eldeeb A.Z., Zohair A., Kandil A.M., Elnagar A., Zil-E-Ali A., Jabbar A., Snaith A.C., Costas-Chavarri A., Austraite A., Mistry A., Olaolorun A., Ajao A.E., Jubran A.F., Shamasneh A., Abouelnasr A., Al-Buhaisi A., Bowabsak A., Jamassi A.E., Elazab A., Elhadad A., Fergany A., Habeebullah A., Shabkah A., Shaheen A., Adesina A., Baird A., Grant A., Ball A., Cacurri A., Mphatsoe A.M., Luc A.R., Matheu A., Munera A., Bedada A.G., Favero A., Maniscalco A., Calua A.C., Fowler A.J., Gerosa A., Horobjowsky A., De Sousa A.V., Farrugia A., Arnaud A.P., Russo A.A., Gulielmi A., Ababneh A., El Dahab A.A., Ata A.A.A., Niazi A.K., Kiasat A., Hammad A.M., Zardab A., Balkan A.Z.A., Toeema A.G., Sadek A., Filatau A., Latif A., Suarez A.A.B., Faure A., Niragire A., Robledo-Rabanal A., Broch A., Hasheminia A., Macdonald A., Ndajiwo A., Novak A., Mutabazi A.Z., Beleno A.E.M., Cheah A.E.Z., Elrazek A.A., Nasr A., Sanad A., Elgendy A.H., Cury A.D.L., Ibrahim A., Martin A., Althwainy A., Abouzahra A., Mohammed A.E., Kourdouli A., Hashish A., Birring A., Al Meligy A., Abdelhamid A., Majid A.H.H.A., Mohammad A., Kaci A.A., Omar A.A., Elsawy A., Bekhet A.H., Reda A., Qumbos A.A., Elmashala A., Gado A., Mohamed A.M., Mohamed A., Rasendran A., Saleh A.A., Fadel A., Hassaan A., Hossameldin A., Elkorashy A.M., Hafez A.T., Faruq A., Aglan A., Bautista A.C.M., Contreras-Vergara A.L., Barrantes A.M.S., De Freitas A.V.C., Freitas A.V., Rashid A., Abdelazeam A.R., Kirishnan A., Majbar A., Bamicha A., Stefanopoulos A., Thorell A., Das A., Dubois A., Mihaljevic A.L., Navarro A., Allegri A., Armellini A., Belli A., Bondurri A., Moran A.E.R., Natili A., Ruzzenente A., Simioni A., Haloho A., Tanase A., Kolosov A., Subocius A., Robertson A.G.N., Kirby A., McGuigan A., Spina A., Litvin A., Burmistrovas A., Strazdas A., Arenas A., Bhangu A., Rudzenskaite A., Rojas A.D.P., Dell A., Mejia A.G.V., Charles A., Antoniozzi A., Benevento A., Tselos A., El-Ma'doul A.S., Sreedharan A., Bhatnagar A., Kjellin A., Lasek A., Maffioli A., Powell A., Rinaldi A., Watts A., lo Conte A., Bigaran A., Ashton A., Mukin A.D.F., Gulbinas A., Zadoroznas A., Rulie A.S., Ajiboye A., Avoka A., Lai A.C.-H., Davor A., Sander A., Oosterkamp A., Bediako-Bowan A., Brocca A.L., Leal A., Nocito A., La Medina A.R.-D., Taddei A., Atiyeh A., Kojo A.T.T., Driscoll A., Shah A., Vlachogiorgos A., Roslani A.C., Abdelhaq A., del Pilar Paucar A., Picciariello A., Kanani A., Leppaniemi A., Birindelli A., Nesaratnam A., Suyadi A., Velasquez A.J.R., Bonnard A., Agarwal A., Alkaaki A., Vaicius A., Khamajeet A., Reinsoo A., Abouzaid A., Elfarargy A., Kedar A., Alnusairat A., Hamarshi A., Musleh A., Prabhudesai A., Maghrabi A.A., Morsi A., Mitul A.R., Abdelgelil A., Al-Aarag A.A.-R., Rezq A., Salah A., Papailia A., Badwy A., Leusink A., Khan A., Eysa A., Zulkifli A., Mahdi A., Attia A., Attia A.M., Clarissa A., Dulskas A., Parseliunas A., Zani A., Tun A.K., Mironescu A., Mironescu A.S., Scalabre A., Mariani A., Haffreingue A., Thollot A., Usaityte A., Skardziukaite A., Ibraheem A.A.F., Aboarab A., Elsharkawy A.A., El-Sawy A., Elwaey A., Firwana A., Hagar A., Fathy A.M., Ata A.Y., Hamdan A., Taher A.A., Elwan A., Nabawi A., Salman A., Shwky A., Ogunyemi A., Herebat A., Verjee A., Adenekan B., Odeyemi B., Adel B.E., Tawfik B.A., Ozkan B.B., Mohamed B., Nighat B., Albeladi B., Malaga B., Mijuskovic B., Silvestre B.P., Kumar B., Sieda B., Bello B., Alghamdi B., Magdy B., Mahmoud B., Alhassan B., Mowafy B., Brunoni B., Weber B., Sanchez B., Thompson B., Parmentier B., Limoges B., Van Duren B., Wolf B., Dousset B., Grizhja B., Lieske B., Maillot B., Mansour B., Frisk B., Diaconescu B., Martian B.-V., Marinkovic B., Skelly B., Cameron B., Dedekind B., Noukpozounkou B., Chong B.F.H.K., Kumar B.S., de Lima C.V.B., Iacono C., Fairfield C., Samaniego C.S., Cona C., Lopez-Arevalo C., Normile C., Venugopal C., Cabrera C.C.R., Torres C.P.G., Corbellini C., Basto C.A.A., Velasquez C.I.P., Morales C., Nsengiyumva C., Galvez C.P., Capito C., Fernandez C., Diaz-Zorrilla C., Duenas C.G., Felipe C.O., Clifford C., Musyoka C.K., Shaw C.A., Magee C., Muller C., Costa C., Tolg C., Wredberg C., Del Basso C., Grosos C., Mendizabal C.A.A., Miranda C., Razuri C., Ciubotaru C., Chibuye C., Alexandre C., Szeto C.C.L., Dally C., McIntyre C.J., Benyaiche C., Chong C.L., Wong C.S., Gan C., Currow C., Deane C., Goh C.C., Koh C., Yong C.O., Khatri C., Foo C.C., Fok C.Y.J., Kong C., Ceriani C., Kwatiwani C., Yip C., Tedjaatmadja C., Chong C.S., Taieb C., Tan C.L., Bode C., Lee C., Almanon C.L., Hinojosa C., Coompson C.L., Schoewe C., Neophytou C., Major C.P., Panteli C., Mizzi C., Ferousis C., Agalianos C., Anthoulakis C., Barkolias C., Dervenis C., Chai C.-A., Wong C.Y., Fahy C., Evajelista C.V., De Emergencia C., Zarb C., Ali C.D.M., Sharpin C., Puma C.M.H., Rees C.M., Morgan C., Reali C., Arcudi C., Fermani C., Fermani C.G., Nawara C., Onuoha C., Mangan C., Sampson C., Nwokoro C., Jean-Francois C., Marinos C., Mukuzunga C., Bottini C., Gouldthorpe C., Lopez C.E., Fernandes C., Chow C.Y.N., Manipal C.E., Vimalachandran D., Alkhabbaz D., Hemeda D., Brown D., Ljuhar D., Deckelbaum D.L., Jaradat D., Du Plessis D., Soeselo D.A., Cox D., Dabessa D., Rodriguez D.E.M., Hamill D., Nel D., Youssef D., Magri D., Angelieri D., Gui D., Cruz D.H., Sale D., Gbessi D.G., Andreotti D., Kazanavicius D., McCullagh D., McNish D., Merlini D., Cohen D.M., De Boni D., Rossi D., Aziz D.N.A., Grobler D.C., Schivo D., Chiesa D., Mikuckyte D., Dragatas D., Gray D., Elsorogy D.E.A.A., Elsawahly D.M.E., Zahran D., Cadogan D.D., Sanchez D., Bandoh D., Pozo D.A.R., Antezana D., Coletta D., Romani D., Sasia D., Ofner D., Duhoranenayo D., Raptis D.A., Balalis D., Manatakis D.K., Karousos D., Korkolis D., Kyziridis D., Lytras D., Papageorgiou D., Sfougaris D., Zachariades D.-C., Al-Marakby D., Rahmah D.F., Gamal D., Tarek D., Periasammy D., dos Santos D.V., Morton D., Mirghani D., Seto D.M., Cocker D.M., Nepogodiev D., Raptis D., Emadeldin D., Gamil D., Hasan D., Hasanain D., Abdelrouf D.M., Pata D., Mapasse D., Marshall D.C., O'Connor D.B., Danys D., Venskutonis D., Radkowiak D., Bowley D., Majauskyte D., Samaraweera D.I., Jethwani D.L., Iyer D., Khokha D., Paulouski D., Atkins E.T., Anis E., Domini E., Temoche E., Huaman E., Grisin E., Dainius E., Thomas E., Preckailaite E., Alnawam E., Mamdouh E., Aahlin E.K., Kefalidi E., Mensah E., Borg E., Sutanto E.P.R., Marks E., Goldin E., Muzio E., Vendramin E., Sruogiene E.Z., Ciccioli E., Jovine E., Francone E., Jensen E., Basir E.R.M., Snyder E., Teasdale E., Akoto E., Gaignard E., Haraux E., Robert E., Ali E., Gamaly E., Abdallah E., Al-Dakka E., Ahmed E.A., Aljohani E., Taha E.M.S., Al Raouf E.A., Abdelmageed E., Abuqwaider E., Sayma E.A., Elwy E., Emara E., Hashad E., Ibrahim E., Magdy E., Hegazy E.M., Abdulhakeem E.M., Ibrahim E.M., Morshedy E.M., Nofal E., Rashad E., Mansor E.Y., Barrios E., Rausa E., Nwabuoku E., De Luca E., Eyssartier E., Dijan E., Blower E., Jurdell E., Upchurch E., Acquah E., Akatibo E., Runigamugabo E., Alaloul E., Alqahtani E., Dagoe E., Tackie E., Farinella E., Ackom E., Appiah E.K., Farfan E.S.F., Hervieux E., Schadde E., Vicario E., Laugzemys E., Ahounou E.Y.S., Elbanby E., Ezzat E., Elkhalek E.A., Kasem E.A., Eldeen E.A., El-Gizawy E., Elhalawany E., El-Taher E., Gamal E., Ghanem E., Kasem E., Elbanby E.S., Zakaria E., Hany E., Courboin E., Lee E.X., Macdonald E., Niyirera E., Grasset E., Morandi E., Panieri E., Borin E., Voulgaris E., Slapelyte E., Woin E., Macdermid E., Harrison E.M., Khalifah E., Veronese E., Deichsel F., Aquilino F., Sabour F.A., Idris F., Leong F.Q.H., Rasoaherinomenjanahary F., Ali F.M., Iftekhar F., Sayed F., Balogun F., Al Bastawis F., Asi F., Nada F., Elzowawi F., El-Salam F.A., Sroor F., Baluch F., Elgendy F.I., Elkady F., Ntirenganya F., Elsherif F.A., Mohamed F., Al Barrawi F.E., Noor F., Bianco F., Falaschi F., Coccolini F., Zheng F., Zapata F., Alakaloko F., Lee F., Chai F.Y., Iskandar F., Altoe F., Frade F., Djivoh F., Espinoza F., Fernandez-Bueno F., Tale F., Andika F.F.A., Adella F.J., Di Franco F., Rahantasoa F.C.F.P., Henry F., Rahmawati F.N., Dedey F., Primavesi F., Iordache F.-M., Lam F.Y., Koumpa F., Steccanella F., Pata F., Riente F., Giardino F.R., Selvaggi F., Abantanga F., Dossou F., Fujii F., Regalado F., Helene F.-C., Schmitt F., Gyamfi F.E., Owusu F., Aristizabal F.A.N., Hodonou F., Du Toit F., Sauvat F., Wogensen F., Asele F.A., Saravia F., Pardo G., Nita G.E., Gallo G., Luglio G., Tessera G., Abdelazim G., Shimy G., Barnabas G.N., Samson G., Irwin G., El Ashal G., El Sayed G.S., Tawfik G., Humm G., Balducci G., Sila G.C.M., Ihediwa G., Sila G.M., Azzie G., Camilleri G.M., Gemenetzis G., Gkiokas G., Karabelias G., Kyrou G., Tzikos G., Perrotta G., Teufelberger G., Ahlonsou G., Minguez G., Maharaj G., Galiqi G., Elhoseny G., Nagy G.S., Al Saied G., Shamsi G.S., Nastri G., Pata G., Cocorullo G., Curletti G., Pagano G., Pellino G., Confalonieri G., Gravante G., Lauzikas G., Dawnay G., Simutis G., Vasquez G., Landolfo G., Lazzari G., Lamanna G.L., Pascale G., Pesenti G., Sgroi G., Devadasar G.H., Moreira G., Borda-Luque G., Clerico G., Rotunno G., Salamone G., Sammarco G., Lap G., Padmore G., Tugnoli G., Kouraklis G., McLachlan G., Wood G., Ziubryte G., Podevin G., Rosenberg G.S., Yong G.L., Mannu G.S., Banipal G.S., Vega G.M.M., Miguel G.P.S., Fraga G.P., Recinos G., Servin G.R.P., Shiwani H.A., Al-Farram H., Hakim H., Zidan H., Amin H.A.A., Abdulaziz H., El-Badawy H.A., Elwakil H., Tolba H., Elabdin H.Z., Hajeh H., Ahmed H., Saad H., Aliyu H., Ebdewi H., Asumah H., Waleed H., Saad H.A., Youssef H., Natalie H., Royson H., Anderson-Knight H., Burns H., Thomas H.S., Pahlsson H.-I., Lakshmi H.N., Jordan H., Ibraheem H.I., Al-Hameedi H.I.I., Arsyad H.M., Dharamshi H.A., Mostafa H.A., El-Sheemy H., Tahboub H., Kretzmann H., Rashwan H., Abudeeb H., Khaled H., Nurqistan H.D., Bougard H., Baraka H., Gamal H., Shaker H., Miyasato H.S., Mohan H., Woodward H., Franco H., Francois-Coridon H., Lohse H.A.S., Shakshouk H.A.G., Kandil H., Mahmoud H., Kotobi H., Mendel H., Nnaj H., Karismaningtyas H., Cruz H., Magdy H., Bakry H.M., Heng H.E., Thorarinsdottir H., Safa H., Samih H., Mircea H., Sar H.K., Wong H.Y., Chong H.-Y., Kordorwu H.E.K., Glover-Addy H., Decoud H.P., Salem H.K., Dawoud H., Elfeki H., Emadeldin H., Bachri H., Shiwani H., Ali H., El-Kashef H., Mohammed H., Papaskarlatos I.-A., Abdelmotaleb I., AbdelFattah I., Alhabli I., Al-Slaibi I., AlYoussef I., Elzayat I., Elzayyat I., Alomar I.N., Rakha I., Raza I., Bjorklund I., Vasquez I., Rakita I., Hassan I., Adawi I., Njokanma I., Elkadsh I., Iannone I., Havemann I., Kyriazanos I., Patoulias I., Valioulis I., Dan I., Negoi I., Diaconescu I.-B., Montes I., Ortega-Vazquez I., Amole I., Bertuello I., Hanley I., Bsisu I., El Sayed I.M., Alvarez I.I.Z., Lawani I., Al-Azraqi I.A.A., Adel I., Awad I., Qawasmi I., Restrepo I.M., Fitzgerald J.E., Almy J., Sheehan J., Botero J.A.M., Herrera-Matta J., Restrepo J., Mihanovic J., Adeniran J., Brown J., Giles J., Glasbey J., Olivier J., Pape J., Richards J., Wheeler J., Yang J., Shah J., Pagnozzi J., Salcedo J., Amin J., Pastora J., Rosales J., Coronel J., Breaud J., De La Croix Allen Ingabire J., Marret J.-B., Colombani J.-F., Lecompte J.-F., Dalli J., Youssif J.H., Meqbil J., Onimowo J., Cornick J., Jeyakumar J., Nowers J., Rickard J., Skehan J., Makama J., Ting J.R.S., Tan J.J., Stuva J.P.G., Roth J., Luiz J.S., Law J.H., Siaw J.Y., Saw J.E., Abbasy J., Song J., Quezada J.H.J., Amoako J., Wiborg J., Swann J., Carreira J.-A., Edwards J., Vincent J., Tan J.K., Clegg-Lamptey J.-N., Joosten J., Nyberg J., Schultz J.K., Larsen J.W., Bondin J., Camilleri-Brennan J.F., Mora J.J.V., Allen J.L.Y., Whitaker J., Gribauskaite J., Soreide J.A., Narvestad J.K., Ajah J., Dakubo J., Heath J., Wild J.R.L., Setiawan J., Bravo J.A.C., Cardozo J.T., Aguilar-Jimenez J., Garcia-Marin J.A., Chiong J.A.C., Costa-Maia J., Hamasaki J., Hamaguchi J.L.H., Rodicio J.L., Celis J.M.V., Azmitia J.R.A., Ye J., Awuku-Asabre J., Psaila J., Luck J., Clements J.M., Razzaque J., Correa J.C., Carpio J., Gouws J., Matta J.J.H., Carmona J.M., Delgado J.M., Kabba J., Al-Faifi J.J., Vianna J.G.P., Camilleri-Brennan J., Menegussi J., Leroux J., Rod J., Hascoet J., Jimenez J., Oh J., Kutkevicius J., Kuliavas J., Zilinskas J., Lam J.C.Y., Lando J., Li K.H.G., Leung K.W., Lee K.Y., Kabongo K., Pinnagoda K., Hewage K., Kinandu K., Bhopal K.F., Palayan K., Dabbour K., Elshaer K., Bailey K., Hilal K., Bonavia K., Lagunavicius K., Varkalys K., Cross K., Chang K.Y.-C., Reinisch K.B., Whitehurst K., Gash K., Chu K., Lee K., Connor K., Gudlaugsdottir K., Das K., Atobatele K., Janardha K.C., Koay K.L., Poh K.-S., Clement K.D., Sammut K., Tan K.S.K., Aaniana K., Johnson K., Mealy K., Thorsen K., Espinoza K.T., Pluke K., Strupas K., Conlon K.C., Abozeid K., Alhady K., Aljboor K., Dawood K., Elbisomy K.H., Ibrahim K., Khattab K., El Deen K.N., Mahmud K., Qurie K., El-Dien K.S., Bassit K.A., Boukhal K., Ashour K., Lasheen K.T., Abdelbadeai K., Khan K., Syibrah K.Z., Atkinson K., Li K.K.K., Lafferty K., Soreide K., Augestad K.M., Konstantina K., Farmakis K., Gasteratos K., Maceviciute K., Keke K.R., Zamarin K., Styles K., Jasaitis K., Jokubonis K., Cassar K., Chung K.J., Gunaseelan K., Lee K.C., Carabott K., Agbedinu K., Boakye-Yiadom K., Maison K., Asare-Bediako K., Kusi K., Aung K.P., Szeto K.J.-Y., Psarianos K., Uscinas L., Arachchige L.A.J.J., Abusalem L., Lopez L.I.P., Joel L.W.L., Gavagna L., Koskenvuo L., Lorenzon L., Luque L., Fourcade L., Abdullahi L., Ismail L., Khulu L.B., Rodriguez L.-A.M., Yeo L.S., Israelsson L., Bray L.D., Pena L., Licari L., Solaini L., Yeang L.J., Henderson L., Richardson L., Roodt L., Reza L., Urbanavicius L., Venclauskas L., Barrientos L.A.M., Andersson L., Wilson L., Nymo L., Mauro L., Muntean L.I., Muntean L., Jeremic L., Anyanwu L.-J., Ahmed L.A.M., Fuentes-Rivera L., Rodriguez L., Garcia L.S., Sproule L., Eldamaty L., Jamal L., Da Silva L.A., Sabeeh L., Samison L.H., Ansaloni L., Bortolasi L., Turati L., Duinhouwer L., Vida L.C., Fievet L., Selvaggi L., Solis L.A.Z., Chew L.S., Bonavina L., Bucci L., Cloro L.M., Laufer L.A.V., Barneo L., Florez L.J.G., Helguero-Santin L.M., Barreda L.M.A., Tale L., 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M.O., Alghamdi M.S.A., Alsaggaf M.U., Aly M.Y.M., Aledrisy M., Olugbemi M., Madkor M.H., Hosh M., Rashad M., Bassem M., Munhoz M.M., Khajanchi M., Haines M., Ashtari M., Samy M., Abdelkader M., Eldin M.A.B., Gemeah M., Eid M.M., Qenawy M., Seif M., Mahmoud M.I., Aboelsoud M.R., Kimaro M., Alfarsi M.A., Farhan-Alanie M.M.H., Adil M., Alkelani M., Lokman M.A.A., Bin Hasnan M., Daniyan M., Gohar M.E.-S.A.M., Omar M.F.W., Ibrahim M.H., Furqan M.M., Qadir M.R.M., Saqlain M., Shawqi M., Butt M.T., Yahaya M.T., Waqar M., Riaz M.M., Talaat M., Haque M., Rommaneh M., Aljiffry M., Karakahya M., Yakubu M., Alada M., Farhad M., Taher M.M., Rangarajan M., Telfah M.M., Tun M., Attard M., Elsayed N.A.R., El-Sagheer N., Elzahed N., Bekhet N.M., El Hamid N.A., El-Latif N.K.A., Ortiz N., Elsayed N., Johanna N., Carrasco N., Nadeem N., Wright N.J., Mendez N., Samalavicius N.E., Ghandora N., Bustangi N., Di Martino N., Blencowe N., Redgrave N., Botto N., Sutandi N., Sadig N., Kariem N., Behar N., Abebe 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Elebute O., Ogunsua O., Adebola O., Odutola O., Abdelkader O., Abdulbagi O., Aguilera O., Alahmady O., Arafa O., Ghoneim O., Hesham O., Mattar O., Moussa O., Osman O., Salah O., Saleh O., Aboelmagd O., Mosalum O., Ayandipo O.O., Faboya O., Williams O., Adesanya O., Ioannidis O., Alser O.H., Algohary O., Mohamed O., Salah O.M., Hassan O.M.M., Ebrahim O.S., Seifelnasr O., Imoro O., Al-Obaedi O., Coyoy-Gaitan O., Bouali O., Abem O.E., Timothy O.K., Oshati O., Ramazzini P., Naess P.A., Assouto P.A., Sarmah P., Eduard P., Mentula P., Salusso P., Violi P., De Marco P., Aonzo P., Silvani P., Ubiali P., Mao P., Kielty P., Sutton P., Ugalde P., Witherspoon P., Wondoh P., Gastaldi P., Karumnas P., Kondrotas P., Morais P.A.B., Orbegozo P.A.T., Talving P., Koh P.Y., Weber P., Lundgren P.-O., Deutschmann P., Labib P., Monrad-Hansen P.W., Visinskas P., Gultom P.A., Alexander P., Choi P., Mshelbwala P., Amoako P.T., Buisson P., De Bono P., Ndwambi P., Grandinetti P.P., Danelli P., Sileri P., Ligure P., Mingrone P., Yoganathan P., Major P., Francois P., Ignatavicius P., Mazrimas P., Arachchi P.P., Jain P., Kwakyeafriyie P., Har P.A.L., Chin P.X., Malik P., Nashidengo P., Liu Q., Alimi Q., Ballouhey Q., Ellison Q., Tze R.G.E., King R., Moore R., Amandito R., Dorani R.M.N.R., Araujo R., Soley R., Roszkowski R., Galleano R., Narayanan R., Herikstad R., Kamil R., Satoskar R., Kabariti R., Staerkle R.F., Nataraja R., Oumer R., Shaker R., Jonnalagadda R., Jaramillo R.A., Cardozo R.A.M., Mamdouh R., Saadeh R., Rodriguez-Uria R., Claire R., Abdelhamed R., Bratu R.-M., Zilinskiene R., Bennai R.M., Alyahya R., Fakher R., Husseiny R., Khreishi R., Balila R.M.H., Elashry R., El-Din R.A., Alshareef R., Saad R., Melo R., D'cruz R., Rajan R., Karim R., Velasquez R., Gilbert R., Lilford R., Opoku-Agyeman R., Spence R., Gilbert R.W., Hagan R., Alyami R., Ots R., Rakauskas R., Khan R., George R., Karlo R., Kerley R., McIntyre R., Morton R., Parker R., Tyler R., Bugeja R., Tutino R., Villa R., 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Subjects: surgical unmetneed, no keywords listed, appendicitis, global surgery, Financial Stress, Health Care Costs, Appendicitis, Financial Stre, Health Care Cost, Cost of Illness, Humans, appendicitis,economic burden, surgery, Surgery, Appendiciti, Human
Abstract: Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and $73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and $75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially.
Published: 2022

39. Extended Measurement of the Cosmic-Ray Electron and Positron Spectrum from 11 GeV to 4.8 TeV with the Calorimetric Electron Telescope on the International Space Station

Author: O. Adriani, Y. Akaike, K. Asano, Y. Asaoka, M. G. Bagliesi, E. Berti, G. Bigongiari, W. R. Binns, S. Bonechi, M. Bongi, P. Brogi, J. H. Buckley, N. Cannady, G. Castellini, C. Checchia, M. L. Cherry, G. Collazuol, V. Di Felice, K. Ebisawa, H. Fuke, T. G. Guzik, T. Hams, M. Hareyama, N. Hasebe, K. Hibino, M. Ichimura, K. Ioka, W. Ishizaki, M. H. Israel, K. Kasahara, J. Kataoka, R. Kataoka, Y. Katayose, C. Kato, N. Kawanaka, Y. Kawakubo, K. Kohri, H. S. Krawczynski, J. F. Krizmanic, T. Lomtadze, P. Maestro, P. S. Marrocchesi, A. M. Messineo, J. W. Mitchell, S. Miyake, A. A. Moiseev, K. Mori, M. Mori, N. Mori, H. M. Motz, K. Munakata, H. Murakami, S. Nakahira, J. Nishimura, G. A. de Nolfo, S. Okuno, J. F. Ormes, S. Ozawa, L. Pacini, F. Palma, P. Papini, A. V. Penacchioni, B. F. Rauch, S. B. Ricciarini, K. Sakai, T. Sakamoto, M. Sasaki, Y. Shimizu, A. Shiomi, R. Sparvoli, P. Spillantini, F. Stolzi, J. E. Suh, A. Sulaj, I. Takahashi, M. Takayanagi, M. Takita, T. Tamura, N. Tateyama, T. Terasawa, H. Tomida, S. Torii, Y. Tsunesada, Y. Uchihori, S. Ueno, E. Vannuccini, J. P. Wefel, K. Yamaoka, S. Yanagita, A. Yoshida, and K. Yoshida
Published: 2018
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40. Complete Response of Skull Base Inverted Papilloma to Chemotherapy: Case Report

Author: Edward C. Kuan M.D.,M.B.A., John W. Frederick M.D., Miguel F. Palma Diaz M.D., Dean W. Lim M.D., and Jeffrey D. Suh M.D.
Subjects: Otorhinolaryngology, RF1-547, Immunologic diseases. Allergy, RC581-607
Abstract: Background Inverted papilloma (IP) is the most common benign sinonasal neoplasm. Endoscopic techniques, improved understanding of pathophysiology, and novel surgical approaches have allowed rhinologists to treat IPs more effectively, with surgery being the mainstay of therapy. Frontal sinus IP poses a challenge for surgical therapy due to complex anatomy and potentially difficult surgical access. Objectives We reported a unique case of a massive frontal sinus IP that presented with intracranial and orbital extension, with near resolution after chemotherapy. Methods A retrospective case review of a patient with a frontal sinus IP treated at a tertiary academic medical center. Results A 75-year-old male patient presented with nasal obstruction, purulent nasal discharge, and a growing left supraorbital mass. Endoscopy demonstrated a mass that filled both frontal and ethmoid sinuses, with orbital invasion. There also was substantial erosion of the posterior table, which measured 1.73 × 1.40 cm. A biopsy specimen demonstrated IP with carcinoma in situ. The patient was deemed unresectable on initial evaluation and, subsequently, underwent chemotherapy (carboplatin and paclitaxel). The tumor had a dramatic response to chemotherapy, and the patient elected for definitive surgery to remove any residual disease. During surgery, only a small focus of IP was found along the superior wall of the frontal sinus. No tumor was found elsewhere, including at the site of skull base erosion. The final pathology was IP without carcinoma in situ or dysplasia. Conclusion This was the first reported case of chemotherapeutic “debulking” of IP, which facilitated surgical resection, despite substantial intracranial and orbital involvement. Although nearly all IPs can be treated surgically, rare cases, such as unresectable tumors, may benefit from systemic chemotherapy.
Published: 2017
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41. Innovative Tumor Tissue Dissection Tool for Molecular Oncology Diagnostics

Author: Christina Reinsch, Amy C. Y. Lo, Theresa May, Manana Javey, Gabrielle Heilek, Anja Blüher, B. Hinzmann, Ian Tran, Mirjam Feldkamp, Corinna Woestmann, John F. Palma, Sandra Siemann, Charles Havnar, and Lingling Cai
Subjects: 0301 basic medicine, Pathology, medicine.medical_specialty, Lung Neoplasms, Tissue Fixation, Formalin fixed paraffin embedded, Dissection (medical), Medical Oncology, Polymerase Chain Reaction, Molecular oncology, Pathology and Forensic Medicine, Fixatives, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Manual dissection, Carcinoma, Non-Small-Cell Lung, Formaldehyde, Neoplasms, medicine, Humans, Lung, Paraffin Embedding, business.industry, Dissection, High-Throughput Nucleotide Sequencing, Reproducibility of Results, medicine.disease, Tumor tissue, Data Accuracy, ErbB Receptors, 030104 developmental biology, Molecular Diagnostic Techniques, Egfr mutation, 030220 oncology & carcinogenesis, Mutation, Molecular Medicine, Colorectal Neoplasms, business, Tissue Dissection, Automated method
Abstract: Formalin-fixed, paraffin-embedded (FFPE) tissue is the most commonly used material for tumor molecular profiling, therapy selection, and prognostication. Tumor tissue enrichment by tissue dissection is highly recommended to generate quality data reproducibly for use in downstream assays, such as real-time PCR and next-generation sequencing. The aim of this study was to evaluate the performance of the automated tissue dissection tool AVENIO Millisect System compared with a manual dissection method using 18 FFPE tissue specimens. The study assessed performance of these two methods with paraffinized and deparaffinized sections at 5- and 10-μm thickness as well as at low (5% to 10%) and high (>50%) tumor content. In addition, compatibility with various nucleic acid and protein extraction methods was assessed. Overall, dissection by Millisect resulted in statistically significantly higher yields of nucleic acids and protein compared with manual dissection (P = 0.00524). In downstream analysis on a statistically nonpowered sample set, EGFR mutation testing by PCR led to highly concordant results, and next-generation sequencing testing yielded significantly higher allelic frequencies when tissue was dissected by Millisect compared with manual scraping, demonstrating noninferiority of the automated method. In summary, the AVENIO Millisect System may replace manual labor and support automation of FFPE tumor tissue workflows in clinical molecular laboratories with high testing volumes with adequate validation.
Published: 2021

42. Plasma-Based Measurements of Tumor Heterogeneity Correlate with Clinical Outcomes in Metastatic Colorectal Cancer

Author: Stephanie J. Yaung, Christine Ju, Sandeep Gattam, Alan Nicholas, Nicolas Sommer, Johanna C. Bendell, Herbert I. Hurwitz, John J. Lee, Fergal Casey, Richard Price, and John F. Palma
Subjects: Cancer Research, Oncology, tumor heterogeneity, intratumor heterogeneity, ctDNA, circulating tumor DNA, liquid biopsy, metastatic cancer, colorectal cancer, mCRC, CRC
Abstract: Sequencing circulating tumor DNA (ctDNA) from liquid biopsies may better assess tumor heterogeneity than limited sampling of tumor tissue. Here, we explore ctDNA-based heterogeneity and its correlation with treatment outcome in STEAM, which assessed efficacy and safety of concurrent and sequential FOLFOXIRI-bevacizumab (BEV) vs. FOLFOX-BEV for first-line treatment of metastatic colorectal cancer. We sequenced 146 pre-induction and 89 post-induction patient plasmas with a 198-kilobase capture-based assay, and applied Mutant-Allele Tumor Heterogeneity (MATH), a traditionally tissue-based calculation of allele frequency distribution, on somatic mutations detected in plasma. Higher levels of MATH, particularly in the post-induction sample, were associated with shorter progression-free survival (PFS). Patients with high MATH vs. low MATH in post-induction plasma had shorter PFS (7.2 vs. 11.7 months; hazard ratio, 3.23; 95% confidence interval, 1.85–5.63; log-rank p < 0.0001). These results suggest ctDNA-based tumor heterogeneity may have potential prognostic value in metastatic cancers.
Published: 2022
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43. Early Assessment of Chemotherapy Response in Advanced Non-Small Cell Lung Cancer with Circulating Tumor DNA

Author: Stephanie J. Yaung, Corinna Woestmann, Christine Ju, Xiaoju Max Ma, Sandeep Gattam, Yiyong Zhou, Liu Xi, Subrata Pal, Aarthi Balasubramanyam, Nalin Tikoo, Claus Peter Heussel, Michael Thomas, Mark Kriegsmann, Michael Meister, Marc A. Schneider, Felix J. Herth, Birgit Wehnl, Maximilian Diehn, Ash A. Alizadeh, John F. Palma, and Thomas Muley
Subjects: Cancer Research, Oncology, ctDNA, NSCLC, chemotherapy, NGS, early molecular response
Abstract: Monitoring treatment efficacy early during therapy could enable a change in treatment to improve patient outcomes. We report an early assessment of response to treatment in advanced NSCLC using a plasma-only strategy to measure changes in ctDNA levels after one cycle of chemotherapy. Plasma samples were collected from 92 patients with Stage IIIB-IV NSCLC treated with first-line chemo- or chemoradiation therapies in an observational, prospective study. Retrospective ctDNA analysis was performed using next-generation sequencing with a targeted 198-kb panel designed for lung cancer surveillance and monitoring. We assessed whether changes in ctDNA levels after one or two cycles of treatment were associated with clinical outcomes. Subjects with ≤50% decrease in ctDNA level after one cycle of chemotherapy had a lower 6-month progression-free survival rate (33% vs. 58%, HR 2.3, 95% CI 1.2 to 4.2, log-rank p = 0.009) and a lower 12-month overall survival rate (25% vs. 70%, HR 4.3, 95% CI 2.2 to 9.7, log-rank p < 0.001). Subjects with ≤50% decrease in ctDNA level after two cycles of chemotherapy also had shorter survival. Using non-invasive liquid biopsies to measure early changes in ctDNA levels in response to chemotherapy may help identify non-responders before standard-of-care imaging in advanced NSCLC.
Published: 2022

44. A Multicenter Study on the Impact of Gender, Age, and Dual Diagnosis on Substance Consumption and Mental Health Status in Outpatients Treated for Substance Use Disorders During COVID-19 Lockdown

Author: Constanza, Daigre, Lara, Grau-López, Raúl F, Palma-Alvarez, Marta, Perea-Ortueta, Marta, Sorribes-Puertas, Pedro, Serrano-Pérez, Marta, Quesada, Lidia, Segura, Marta, Coronado, Josep Antoni, Ramos-Quiroga, and Joan, Colom
Subjects: Adult, Male, Psychiatry and Mental health, Cocaine, Diagnosis, Dual (Psychiatry), Substance-Related Disorders, Health Status, Communicable Disease Control, Outpatients, COVID-19, Humans, Female, Middle Aged
Published: 2022

45. Possible effects on avionics induced by terrestrial gamma-ray flashes

Author: M. Tavani, A. Argan, A. Paccagnella, A. Pesoli, F. Palma, S. Gerardin, M. Bagatin, A. Trois, P. Picozza, P. Benvenuti, E. Flamini, M. Marisaldi, C. Pittori, and P. Giommi
Subjects: Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract: Terrestrial gamma-ray flashes (TGFs) are impulsive (intrinsically sub-millisecond) events associated with lightning in powerful thunderstorms. TGFs turn out to be very powerful natural accelerators known to accelerate particles and generate radiation up to hundreds of MeV energies. The number ratio of TGFs over normal lightning has been measured in tropical regions to be near 10−4. We address in this Article the issue of the possible susceptibility of typical aircraft electronics exposed to TGF particle, gamma ray and neutron irradiation. We consider possible scenarios regarding the intensity, the duration, and geometry of TGFs influencing nearby aircraft, and study their effects on electronic equipment. We calculate, for different assumptions, the total dose and the dose-rate, and estimate single-event-effects. We find that in addition to the electromagnetic component (electrons/positrons, gamma rays) also secondary neutrons produced by gamma-ray photo production in the aircraft structure substantially contribute to single-event effects in critical semiconductors components. Depending on the physical characteristics and geometry, TGFs may deliver a large flux of neutrons within a few milliseconds in an aircraft. This flux is calculated to be orders of magnitude larger than the natural cosmic-ray background, and may constitute a serious hazard to aircraft electronic equipment. We present a series of numerical simulations supporting our conclusions. Our results suggest the necessity of dedicated measurement campaigns addressing the radiative and particle environment of aircraft near or within thunderstorms.
Published: 2013
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46. Assessment of a Highly Curated Somatic Oncology Database to Aid in the Interpretation of Clinically Important Variants in Next-Generation Sequencing Results

Author: John F. Palma, Shuba Krishna, Christine Ju, Liu Xi, Stephanie J. Yaung, and Maximilian Schmid
Subjects: 0301 basic medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, Somatic cell, MEDLINE, Adenocarcinoma of Lung, computer.software_genre, Polymorphism, Single Nucleotide, DNA sequencing, Circulating Tumor DNA, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Crizotinib, Carcinoma, Non-Small-Cell Lung, Internal medicine, Databases, Genetic, Biomarkers, Tumor, medicine, Drug approval, Humans, Anaplastic Lymphoma Kinase, Lung cancer, Protein Kinase Inhibitors, Retrospective Studies, Database, business.industry, High-Throughput Nucleotide Sequencing, Cancer, medicine.disease, ErbB Receptors, Treatment Outcome, 030104 developmental biology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, Mutation (genetic algorithm), Molecular Medicine, business, computer, Software, medicine.drug
Abstract: This study evaluated the accuracy of NAVIFY Mutation Profiler, a cloud-based CE-IVD software that aids in interpreting clinically relevant variants detected in somatic oncology next-generation sequencing tests. This tool reports tiered classifications based on different levels of clinical evidence from a highly curated, regularly updated database derived from medical guidelines, drug approvals, and peer-reviewed literature. A retrospective analysis was performed on next-generation sequencing results from 37 lung cancer cases treated with chemotherapy (n = 10), EGFR tyrosine kinase inhibitor (TKI) (n = 5), or ALK TKI (n = 22). Several aspects were assessed, including accuracy of interpretation compared with manual curation, validity of curation content updates over time, and agreement with public databases. For chemotherapy cases with no targetable biomarkers, NAVIFY Mutation Profiler did not identify any targeted therapies. In EGFR and ALK TKI cases, the software associated appropriate targeted therapies and accurately interpreted variant combinations containing drug-resistance variants. Of the nine unique ALK mutations conferring resistance to crizotinib, NAVIFY Mutation Profiler provided correct annotation for all mutations, whereas OncoKB and Catalogue of Somatic Mutations in Cancer indicated crizotinib resistance for eight of nine mutations. For 145 variants analyzed, NAVIFY Mutation Profiler and OncoKB showed substantial agreement (Cohen κ = 0.62) for classifying actionable mutations. Furthermore, NAVIFY Mutation Profiler presented accurate targeted therapies across different regions and remained up-to-date with evolving regional approvals and medical guidelines.
Published: 2020

47. Clonal Hematopoiesis in Late-Stage Non–Small-Cell Lung Cancer and Its Impact on Targeted Panel Next-Generation Sequencing

Author: John F. Palma, Maureen Peterson, Yuqiu Jiang, Stephanie J. Yaung, Wei Zou, Namrata Patil, and Frederike Fuhlbrück
Subjects: 0301 basic medicine, Cancer Research, Clonal hematopoiesis, Late stage, Biology, medicine.disease, DNA sequencing, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Oncology, chemistry, 030220 oncology & carcinogenesis, medicine, Cancer research, Non small cell, Lung cancer, DNA
Abstract: PURPOSE Somatic mutations derived from the expansion of clonal populations of blood cells (clonal hematopoiesis of indeterminate potential, or CHIP) may be detected in sequencing of cell-free DNA (cfDNA) samples. We evaluated the potential implications of CHIP in targeted sequencing of plasma samples using matched peripheral blood mononuclear cells (PBMCs) from patients with lung cancer to identify potential CHIP-associated mutations. MATERIALS AND METHODS A total of 332 plasma and corresponding PBMC samples were collected predose, cycle 1 day 1 (C1D1), from the randomized, phase III study (OAK) comparing atezolizumab versus docetaxel in previously treated patients with non–small-cell lung cancer (NSCLC). The samples were analyzed with the AVENIO ctDNA Surveillance Kit (for research use only; not for use in diagnostic procedures), a 198-kb next-generation sequencing panel targeting cancer-related genes. CHIP variants were assessed by analyzing both plasma and PBMC sequencing data. RESULTS A range of zero to eight CHIP variants (median = one) was detected per cfDNA sample. Most of these variants were not in the Database of Single Nucleotide Polymorphisms (dbSNP). The number of CHIP variants was positively associated with age, and TP53 was the most frequently mutated gene. Furthermore, the allele frequency was less variable over time for CHIP variants than for tumor-derived variants. CONCLUSION CHIP-derived mutations are present in late-stage NSCLC. However, not all plasma samples had CHIP mutations detected with targeted panel sequencing. Paired PBMC sequencing analysis may be needed to remove CHIP variants for comprehensive genomic profiling using plasma samples to identify true somatic mutations.
Published: 2020

48. Admitted for an Eating Disorder: Challenges Clinical Psychologists Face in Working with Patients and Their Families on a Consultation–Liaison Service in a Tertiary Pediatric Hospital

Author: Ryan D. Davidson, Imari Ashley F. Palma, I. Simona Bujoreanu, Lauren M. Potthoff, and Katharine Thomson
Subjects: Service (business), 050103 clinical psychology, medicine.medical_specialty, business.industry, 05 social sciences, Face (sociological concept), medicine.disease, Mental health, 03 medical and health sciences, Clinical Psychology, Health psychology, Eating disorders, 0302 clinical medicine, Family medicine, Pediatric hospital, Psychiatric diagnosis, medicine, 0501 psychology and cognitive sciences, 030212 general & internal medicine, Medical diagnosis, business
Abstract: Eating disorders are one of the most common causes of pediatric hospitalizations due to primary mental health diagnoses. The purpose of this article is to discuss the challenges clinical psychologists face in working with patients with eating disorders and their families during medical admissions. Using the Psychiatry Consultation Service at a tertiary pediatric academic medical center in the Northeast as a framework, authors present the responsibilities of clinical psychologists on this service and their role within the larger, interdisciplinary team. Topics addressed also include systemic challenges, medical and psychiatric comorbidities, and differential psychiatric diagnoses. Case examples are provided to highlight various challenges as well as potential solutions and approaches. Clinical implications, limitations, and directions for future research are also discussed.
Published: 2020

49. Disease Monitoring Using Post-induction Circulating Tumor DNA Analysis Following First-Line Therapy in Patients with Metastatic Colorectal Cancer

Author: Richard Price, Christine Ju, Johanna C. Bendell, Herbert Hurwitz, Xiaoju Max Ma, John Lee, Nalin Tikoo, Christoph Mancao, Lijing Yao, Alex Lovejoy, Alan Nicholas, Stephanie J. Yaung, John F. Palma, and Nicolas Sommer
Subjects: Adult, Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Bevacizumab, Colon, Colorectal cancer, Population, Kaplan-Meier Estimate, medicine.disease_cause, Circulating Tumor DNA, Young Adult, 03 medical and health sciences, 0302 clinical medicine, FOLFOX, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, medicine, Humans, Intestinal Mucosa, education, Aged, Neoplasm Staging, education.field_of_study, business.industry, Rectum, Induction Chemotherapy, Middle Aged, Prognosis, medicine.disease, Progression-Free Survival, digestive system diseases, Oxaliplatin, Irinotecan, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation, FOLFIRI, Female, KRAS, Colorectal Neoplasms, business, Follow-Up Studies, medicine.drug
Abstract: Purpose:We assessed plasma circulating tumor DNA (ctDNA) level as a prognostic marker for progression-free survival (PFS) following first-line metastatic colorectal cancer (mCRC) therapy.Experimental Design:The Sequencing Triplet With Avastin and Maintenance (STEAM) was a randomized, phase II trial investigating efficacy of bevacizumab (BEV) plus 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX) and 5-fluorouracil/leucovorin/irinotecan (FOLFIRI), administered concurrently or sequentially, versus FOLFOX-BEV in first-line mCRC. Evaluation of biomarkers associated with treatment outcomes was an exploratory endpoint. Patients in the biomarker-evaluable population (BEP) had 1 tissue sample, 1 pre-induction plasma sample, and 1 post-induction plasma sample collected ≤60 days of induction from last drug date.Results:Among the 280 patients enrolled in STEAM, 183 had sequenced and evaluable tumor tissue, 118 had matched pre-induction plasma, and 54 (BEP) had ctDNA-evaluable sequencing data for pre- and post-induction plasma. The most common somatic variants in tumor tissue and pre-induction plasma were TP53, APC, and KRAS. Patients with lower-than-median versus higher-than-median post-induction mean allele fraction (mAF) levels had longer median PFS (17.7 vs. 7.5 months, HR, 0.33; 95% confidence interval, 0.17–0.63). Higher levels of post-induction mAF and post-induction mean mutant molecules per milliliter (mMMPM), and changes in ctDNA (stratified by a 10-fold or 100-fold reduction in mAF between pre- and post-induction plasma), were associated with shorter PFS. Post-induction mAF and mMMPM generally correlated with each other (ρ = 0.987, P < 0.0001).Conclusions:ctDNA quantification in post-induction plasma may serve as a prognostic biomarker for mCRC post-treatment outcomes.
Published: 2020

50. Comparison of two methods for obtaining and transporting corneal samples in suspected infectious keratitis

Author: F. Palma-Carvajal, I. Blanco-Domínguez, M. Sainz-de-la-Maza, M.R. Chang-Sotomayor, N. Sabater-Cruz, J. Bosch-Mestres, V. Llorens Bellés, Josep Torras-Sanvicens, and M. Latasiewicz
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Corneal Infiltrates, Transportation, Single sample, Clinical settings, Infectious Keratitis, Eye Infections, Bacterial, Specimen Handling, Cornea, Tissue Culture Techniques, Young Adult, Ophthalmology, Transport medium, Humans, Medicine, Corneal Ulcer, Aged, Collection methods, Aged, 80 and over, Keratitis, Alternative methods, business.industry, Middle Aged, Standard methods, Culture Media, Tissue and Organ Harvesting, Female, business
Abstract: Summary Background and purpose The purpose of this study is to compare two alternative methods of collecting and transporting media for the diagnosis of corneal ulcers, as not all clinical settings have conventional culture materials and transport media available. Methods In this open-label, prospective, comparative, and randomized study, patients with clinical suspicion of infectious keratitis with high risk of loss of vision had corneal specimens collected using two methods and transport media: Eswab scraping with Amies transport medium and 23-gauge needle scraping in BACTEC Peds broth. The order of each collection method was randomized. The samples were processed by standard methods, comparing the positivity frequencies for both by parametric and nonparametric tests, according to normality criteria. Results Corneal infiltrates from 40 eyes of 40 patients were analyzed. Culture positivity rate was 50% for Eswab and 35% for 23-gauge needle (P = 0.258). The overall growth rate of the two methods combined was not higher than with the swab alone. The results obtained with a swab were not influenced by the collection sequence (P = 0.112); however, the positivity rate was significantly higher when the sample taken with the needle was performed first (P = 0.046). Conclusions The single sample Eswab method of collection and transportation for the diagnosis of high risk corneal ulcers is a valid alternative and can be used in cases in which, for various reasons, there is no access to the full set of traditional culture materials.
Published: 2020

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