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131 results on '"F. Pizzarelli"'

1. 'Non tutte le donne sono acide'

Author

S. Michelassi, L. Grassi, and F. Pizzarelli

Subjects
Internal medicine, RC31-1245, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract non disponibile

Published
2018
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2. Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study 'Hephaestus'

Author

Serena Farruggio, Giuseppe Ferro, Stefano Cusinato, Oliviero Filiberti, Alessandro Capitanini, L Dani, Pietro Dattolo, Alessandro Toccafondi, Vincenzo Cantaluppi, F. Pizzarelli, Vincenzo Miniello, Elena Grossini, Alessandro Domenico Quercia, Aldo Casani, Vincenzo Panichi, Massimiliano Migliori, Cristina Grimaldi, and Maurizio Borzumati

Subjects
Adult, Nephrology, medicine.medical_specialty, medicine.medical_treatment, 030232 urology & nephrology, Urology, Hemodiafiltration, 030204 cardiovascular system & hematology, On-line hemodiafiltration, Klotho, Citric Acid, 03 medical and health sciences, chemistry.chemical_compound, C-Reactive Protein, Citrate dialysate, Inflammation, Interleukin-6, Aged, Aged, 80 and over, Humans, Middle Aged, Prospective Studies, Renal Dialysis, 0302 clinical medicine, Interquartile range, Internal medicine, 80 and over, medicine, Dialysis, biology, business.industry, Confounding, C-reactive protein, chemistry, biology.protein, Hemodialysis, Citric acid, business
Abstract

Studies addressing the anti-inflammatory properties of citrate dialysate enrolled patients in both hemodialysis (HD) and hemodiafiltration (HDF), the latter not adjusted for adequate convective exchange. This is a potential source of confounding in that HDF itself has anti-inflammatory effects regardless of the buffer, and optimal clinical outcomes are related to the amount of convection. To distinguish the merits of the buffer from those of convection, we performed a 6-month, prospective, randomized, crossover AB-BA study. Comparisons were made during the 3-month study period of on-line HDF with standard dialysate containing three mmol of acetic acid (OL-HDFst) and the 3-month of OL-HDF with dialysate containing one mmol of citric acid (OL-HDFcit). Primary outcome measure of the study was interleukin-6 (IL-6). Klotho, high sensitivity C-reactive protein (hsCRP), fetuin and routine biochemical parameters were also analyzed. We analyzed 47 patients (mean age 64 years, range 27-84 years) enrolled in 10 participating Nephrology Units. Convective volumes were around 25 L/session with 90 percent of sessions > 20 L and s2-microglobulin reduction rate 76% in both HDFs. Baseline median IL-6 values in OL-HDFst were 5.6 pg/ml (25:75 interquartile range IQR 2.9:10.6) and in OL-HDFcit 6.6 pg/ml (IQR 3.4:11.4 pg/ml). The difference was not statistically significant (p 0.88). IL-6 values were lower during OL-HDFcit than during OL-HDFst, both when analyzed as the median difference of overall IL-6 values (p 0.02) and as the median of pairwise differences between the baseline and the 3-month time points (p 0.03). The overall hsCRP values too, were lower during OL-HDFcit than during OL-HDFst (p 0.01). Klotho levels showed a time effect (p 0.02) and the increase was significant only during OL-HDFcit (p 0.01). Citrate buffer modulated IL-6, hsCRP and Klotho levels during high volume OL-HDF. These results are not attributable to differences in the dialysis technology that was applied and may suggest a potential biological effect of citrate on CKD-associated inflammatory state. ClinicalTrials.gov identifier NCT02863016.

Published
2021

3. Complicanze Tardive Non Comuni Della Venipuntura a Siti Costanti (Buttonhole Technique, BH): Descrizione Di Due Casi Clinici

Author

F. Pizzarelli, Giuseppe Ferro, Eugenio Romano, and Pierfrancesco Frosini

Subjects
Incannulamento della fistola artero-venosa, lcsh:Internal medicine, medicine.medical_specialty, Venipuncture, business.industry, Incidence (epidemiology), Vascular access, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, medicine.disease, Buttonhole, Surgery, Sepsis, Pathogenesis, Ecografia, Medicine, Pharmacology (medical), Clinical significance, lcsh:RC31-1245, business, Complication, Accessi vascolari
Abstract

La tecnica di venipuntura a siti costanti (buttonhole) è un’alternativa alle tecniche abituali per l’incannulamento della fistola artero-venosa. Gli studi clinici e le review a oggi pubblicati non indicano chiaramente una superiorità in termini di maggiori vantaggi e minori complicanze rispetto alla venipuntura a siti variabili, tuttavia le complicanze, anche se rare, sono rilevanti (p. es., sepsi). In questo articolo vengono descritte alcune lesioni riscontrate ecograficamente, il cui ruolo patogenetico potrebbe verosimilmente essere in relazione sia con il malfunzionamento della FAV che con l’insorgenza della sepsi.

Published
2018

4. 'Non tutte le donne sono acide'

Author

F. Pizzarelli, S. Michelassi, and L. Grassi

Subjects
lcsh:Internal medicine, General Medicine, lcsh:RC31-1245, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923
Abstract

non disponibile

Published
2018

5. Pathophysiology and clinical studies in CKD 1-5

Author

A. Gerakis, A. Halapas, M. Chrissoheris, I. Giatras, R. Andritsou, I. Nikolaou, N. Bouboulis, E. Pattakos, K. Spargias, R. Kalaitzidis, D. Karasavvidou, K. Pappas, G. Katatsis, A. Tatsioni, K. Siamopoulos, M. H. de Borst, R. Hajhosseiny, H. Tamez, J. Wenger, R. Thadhani, D. J. Goldsmith, L. Zanoli, S. Rastelli, C. Marcantoni, J. Blanco, C. Tamburino, P. Castellino, T. Larsen, J. Jensen, J. Bech, E. Pedersen, F. Mose, D. Leckstrom, T. Bhuvanakrishna, A. McGrath, D. Goldsmith, K. Muras, A. Masajtis-Zagajewska, M. Nowicki, H. C. Rayner, J. Baharani, S. Smith, V. Suresh, I. Dasgupta, F. Zarzoulas, O. Balafa, L. Di Lullo, F. Floccari, R. Rivera, A. Gorini, M. Malaguti, V. Barbera, A. Granata, A. Santoboni, M. Luczak, D. Formanowicz, E. Pawliczak, M. Wanic-Kossowska, L. Koziol, M. Figlerowicz, J. Bommer, M. Fliser, P. Roth, D. Saure, S. Vettoretti, C. Alfieri, R. Floreani, A. Regalia, C. Bonanomi, R. Meazza, F. Magrini, P. Messa, V. Jankowski, W. Zidek, J. Joachim, K. Lee, I. H. Hwang, S. B. Lee, D. W. Lee, I. Y. Kim, I. S. Kwak, E. Y. Seong, M. J. Shin, H. Rhee, B. Y. Yang, P. Dattolo, S. Michelassi, S. Sisca, M. Allinovi, M. Amidone, A. Mehmetaj, F. Pizzarelli, V. Filiopoulos, N. Manolios, D. Hadjiyannakos, D. Arvanitis, K. Panagiotopoulos, D. Vlassopoulos, J. S. Kim, B. G. Han, S. O. Choi, J. W. Yang, S. Shojai, A. Babu, P. Boddana, D. Dipankar, R. Alvarado, G. Garcia-Pino, E. Ruiz-Donoso, E. Chavez, E. Luna, F. Caravaca, H. Geiger, S. Buttner, L.-L. Lv, Y. Cao, M. Zheng, B.-C. Liu, G. N. Kouvelos, V. D. Raikou, E. M. Arnaoutoglou, H. J. Milionis, J. N. Boletis, M. I. Matsagkas, I. Raiola, F. Trepiccione, M. Pluvio, R. Raiola, G. Capasso, I. Kaykov, L. Kukoleva, R. Zverkov, A. Smirnov, S. Hammami, A. Frih, S. Hajem, M. Hammami, and L. Wan

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Intensive care medicine, business, Pathophysiology
Published
2013

6. Acute inflammatory bowel

Author

Giuseppe Ferro, Piercarlo Ballo, Pietro Dattolo, Giuseppe Mangialavori, Francesca Fusco, Leandro Chiodi, Giulia Sansavini, Alam Mehmetaj, Stefano Michelassi, and F. Pizzarelli

Subjects
General Medicine
Published
2013

7. Renal anaemia - CKD 5D

Author

K. Takasawa, C. Takaeda, M. Higuchi, T. Maeda, N. Tomosugi, N. Ueda, Y. Sasaki, M. Ikezoe, M. Hagiwara, S. Furuhata, M. Murakami, Y. Shimonaka, S. Yamazaki, S. Hamahata, M. Oue, T. Kuragano, M. Furuta, M. Yahiro, A. Kida, Y. Otaki, Y. Hasuike, H. Nonoguchi, T. Nakanishi, P. Sarafidis, A. Rumjon, D. Ackland, H. Maclaughlin, S. S. Bansal, I. C. Macdougall, V. Panichi, A. Rosati, E. Malagnino, R. Giusti, A. Casani, G. Betti, P. Conti, G. Bernabini, C. Gabrielli, D. Caiani, A. Scatena, M. Migliori, F. Pizzarelli, E. Mitsopoulos, M. Tsiatsiou, I. Minasidis, V. Kousoula, E. Intzevidou, P. Passadakis, V. Vargemezis, D. Tsakiris, S. W. Lines, A. M. Carter, E. J. Dunn, M. J. Wright, R. Aoyagi, T. Miura, L. De Paola, G. Lombardi, G. Coppolino, L. Lombardi, H. Fukumoto, S. Kaibe, M. Tokuyama, M. Hiwasa, T. Miyamoto, H. Ohue, A. Matsumoto, K. Toyoda, J. Rottembourg, C. Emery, A. Lafuma, J. Wernli, L. Zakin, L. Mahi, D. Borzych-Duzalka, Y. Bilginer, L. Pape, I. S. Ha, M. Bak, A. Chua, L. Rees, S. Pesle, F. Cano, A. Urzykowska, S. Emre, J. Russcasso, V. Ramela, N. Printza, C. White, D. Kuzmanovska, V. Andrea, D. Muller-Wiefel, B. Warady, F. Schaefer, J. H. Chung, M. K. Park, H. L. Kim, B. C. Shin, T. Fujikawa, T. Kuji, M. Kakimoto, K. Shibata, H. Satta, M. Nishihara, S. Kawata, N. Koguchi, Y. Toya, S. Umemura, V. David, G. Michel, H. Maxime, L. Paul, K. Sebastien, V. Francois, V. Kuntsevich, Y. Dou, S. Thijssen, N. W. Levin, P. Kotanko, B. S. Kim, W. D. Park, H. C. Song, H. G. Kim, Y.-O. Kim, K. Woodburn, K.-L. Fong, Y. Moriya, Y. Tagawa, F. Kanda, N. Morita, G. London, P. Zaoui, A. Covic, F. Dellanna, D. Goldsmith, L. Gesualdo, J. Mann, C. Combe, M. Turner, M. Meunzberg, K. Macdonald, I. Abraham, A. Guerin, M. Diaconita, R. Apruzzese, A. Kruse, G. Ouellet, C. Bond, D. Jensen, S. Wang, E. Pham, J. Rubin, M. Sika, R. Niecestro, S. Sloneker, P. Strzemienski, E. Solon, D. Stamopoulos, N. Mpakirtzi, E. Grapsa, B. Gogola, E. Manios, N. Afentakis, and J. Ewer

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Internal medicine, medicine, Renal anaemia, business
Published
2012

8. Clinical Nephrology - Epidemiology II

Author

H. Agnes, P. Kalman, A. Jozsef, B. Henrik, I. Mucsi, K. Kamata, T. Sano, S. Naito, T. Okamoto, C. Okina, M. Kamata, J. Murano, K. Kobayashi, M. Uchida, T. Aoyama, Y. Takeuchi, Y. Nagaba, H. Sakamoto, C. Torino, V. Panuccio, A. Clementi, M. Garozzo, G. Bonanno, R. Boito, G. Natale, T. Cicchetti, A. Chippari, D. Logozzo, G. Alati, S. Cassani, A. Sellaro, G. D'arrigo, G. Tripepi, A. Roberta, M. Postorino, F. Mallamaci, C. Zoccali, E. Buonanno, S. Brancaccio, V. Fimiani, P. Napolitano, R. Spadola, L. Morrone, B. DI Iorio, D. Russo, A. Betriu, M. Martinez-Alonso, T. Vidal, J. Valdivielso, E. Fernandez, F. Bernadette, B. Jean-Baptiste, L. Frimat, N. D. Madala, G. P. Thusi, N. Sibisi, B. G. Mazibuko, A. G. H. Assounga, N.-C. Tsai, H.-H. Wang, Y.-C. Chen, C.-C. Hung, S.-J. Hwang, H.-C. Chen, P. Branco, T. Adragao, R. Birne, A. R. Martins, R. Vizinho, A. Gaspar, M. J. Grilo, J. D. Barata, D. Bonhorst, P. Adragao, J. S. Kim, J. W. Yang, M. K. Kim, S. O. Choi, B. G. Han, N. Nathalie, E. Sunny, G. Glorieux, B. Daniela, B. Fellype, L. Sophie, L. Horst D, M. Ziad, V. Raymond, M. Yanai, K. Okada, K. Takeuchi, K. Nitta, S. Takahashi, M. Morena, I. Jaussent, A. Halkovich, A.-M. Dupuy, A.-S. Bargnoux, L. Chenine, H. Leray-Moragues, K. Klouche, H. Vernhet, B. Canaud, J.-P. Cristol, A. Shutov, V. Serov, J. Kuznetsova, M. Menzorov, D. Serova, L. Petrescu, A. Zugravu, C. Capusa, S. Stancu, S. Cinca, C. Anghel, D. Timofte, L. Medrihan, D. Ionescu, G. Mircescu, T.-W. Hsu, K.-L. Kuo, S.-C. Hung, D.-C. Tarng, S. Lee, I. Kim, D. Lee, H. Rhee, S. Song, E. Seong, I. Kwak, M. Holzmann, C. Gardell, A. Jeppsson, U. Sartipy, Y. Solak, M. I. Yilmaz, K. Caglar, M. Saglam, H. Yaman, A. Sonmez, H. U. Unal, M. Gok, A. Gaipov, M. Kayrak, T. Eyileten, S. Turk, A. Vural, L. DI Lullo, F. Floccari, R. Rivera, A. Granata, A. D'amelio, F. Logias, G. Otranto, M. Malaguti, A. Santoboni, F. Fiorini, T. Connor, D. Oygar, D. Nitsch, D. Gale, R. Steenkamp, G. H. Neild, P. Maxwell, I. Louise Hogsbro, B. Redal-Baigorri, B. Sautenet, J. M. Halimi, A. Caille, P. Goupille, B. Giraudeau, Y. Oguz, M. Yenicesu, H. Cetinkaya, Y. Ishimoto, T. Ohki, M. Sugahara, T. Kanemitsu, M. Kobayashi, L. Uchida, N. Kotera, S. Tanaka, T. Sugimoto, N. Mise, N. Miyazaki, J. Matsumoto, I. Murata, G. Yoshida, K. Morishita, H. Ushikoshi, K. Nishigaki, S. Ogura, S. Minatoguchi, R. Harvey, A. Ala, D. Banerjee, C. Farmer, J. Irving, H. Hobbs, T. Wheeler, B. Klebe, P. Stevens, G. Selim, O. Stojceva-Taneva, L. Tozija, N. Stojcev, S. Gelev, P. Dzekova-Vidimliski, S. Pavleska, A. Sikole, A. R. Qureshi, M. Evans, M. Stendahl, K. G. Prutz, C. G. Elinder, K. Tamagaki, H. Kado, M. Nakata, T. Kitani, N. Ota, R. Ishida, E. Matsuoka, Y. Shiotsu, M. Ishida, Y. Mori, M. Christelle, N. Rognant, D. Evelyne, F. Sophie, J. Laurent, L. Maurice, R. Silverwood, M. Pierce, D. Kuh, C. Savage, C. Ferro, D. G. Moniek, M. De Goeij, H. Nynke, O. Gurbey, R. Joris, D. Friedo, P. Clayton, B. Grace, A. Cass, S. Mcdonald, V. Lorenzo, M. Martin Conde, A. Dusso, J. M. Valdivielso, D. P. Roggeri, G. Cannella, M. Cozzolino, S. Mazzaferro, P. Messa, D. Brancaccio, R. De Souza Faria, N. Fernandes, J. Lovisi, M. Moura Marta, M. Reboredo, B. Do Vale Pinheiro, M. Bastos, F. Hundt, S. Pabst, C. Hammerstingl, T. Gerhardt, D. Skowasch, R. Woitas, A. A. Lopes, L. F. Silva, C. M. Matos, M. S. Martins, F. A. Silva, G. B. Lopes, F. Pizzarelli, P. Dattolo, S. Michelassi, C. Rossi, S. Bandinelli, M. Mieth, R. Mass, L. Ferrucci, S. Parisi, S. Arduino, R. Attini, F. Fassio, M. Biolcati, A. Pagano, C. Bossotti, M. Ferraresi, P. Gaglioti, T. Todros, G. B. Piccoli, T. M. Salgado, B. Arguello, S. I. Benrimoj, F. Fernandez-Llimos, P. Bailey, C. Tomson, Y. Ben-Shlomo, A. Santoro, P. Rucci, M. Mandreoli, F. Caruso, M. Corradini, M. Flachi, D. Gibertoni, A. Rigotti, G. Russo, M. Fantini, H. S. Mahapatra, S. Choudhury, G. Buxi, N. Sharma, Y. Gupta, V. Sekhar, N. Yanagisawa, M. Ando, A. Ajisawa, K. Tsuchiya, O. Janusz, M. Mikolaj, M. Jacek, R. Boleslaw, S. Prakash, R. Coffin, J. Schold, D. Einstadter, S. Stark, D. Rodgers, M. Howard, A. Sehgal, S. Palmer, A. Tong, B. Manns, J. Craig, M. Ruospo, L. Gargano, G. Strippoli, M. Vecchio, M. Petruzzi, M. De Benedictis, F. Pellegrini, Y. Ohno, E. Ishimura, T. Naganuma, K. Kondo, W. Fukushima, K. Mui, M. Inaba, Y. Hirota, X. Sun, S. Jiang, H. Gu, Y. Chen, C. XI, X. Qiao, X. Chen, E. Daher, G. S. Junior, C. N. Jacinto, R. S. Pimentel, G. B. R. Aguiar, C. B. Lima, R. C. Borges, L. P. C. Mota, J. V. L. Melo, S. A. Melo, V. T. Canamary, M. Alves, S. M. H. A. Araujo, Y. K. Huang, K. Rogacev, B. Cremers, A. Zawada, S. Seiler, N. Binder, P. Ege, G. Grosse-Dunker, I. Heisel, F. Hornof, J. Jeken, N. Rebling, C. Ulrich, B. Scheller, M. Bohm, D. Fliser, G. H. Heine, B. Robinson, M. Wang, B. Bieber, R. Fluck, P. G. Kerr, B. Wikstrom, M. Krishnan, A. Nissenson, R. L. Pisoni, S. Mykleset, T. B. Osthus, B. Waldum, I. Os, J. Buttigieg, A. Cassar, J. Farrugia Agius, M. Hara, M. Yamato, K. Yasuda, and K. Sasaki

Subjects
Transplantation, medicine.medical_specialty, Acute coronary syndrome, business.industry, Red blood cell distribution width, medicine.disease, Sudden death, Uremia, Nephrology, Diabetes mellitus, Internal medicine, Heart failure, medicine, Cardiology, Endothelial dysfunction, business, Kidney disease
Published
2012

9. Cardiovascular complications in CKD 5D

Author

M. Fusaro, M. Noale, G. Tripepi, A. D'angelo, D. Miozzo, M. Gallieni, P.-V. Study Group, M. Tsamelesvili, C. Dimitriadis, A. Papagianni, C. Raidis, G. Efstratiadis, D. Memmos, R. Mutluay, C. Konca Degertekin, U. Derici, S. M. Deger, F. Akkiyal, S. Gultekin, S. Gonen, G. Tacoy, T. Arinsoy, S. Sindel, C. Sanchez-Perales, E. Vazquez, E. Merino, P. Perez Del Barrio, F. J. Borrego, M. J. Borrego, A. Liebana, M. Krzanowski, K. Janda, P. Dumnicka, A. Krasniak, W. Sulowicz, Y.-O. Kim, S.-A. Yoon, Y.-S. Yun, H.-C. Song, B.-S. Kim, M. A. Cheong, A. Pasch, S. Farese, J. Floege, W. Jahnen-Dechent, T. Ohtake, R. Furuya, M. Iwagami, D. Tsutsumi, Y. Mochida, K. Ishioka, M. Oka, K. Maesato, H. Moriya, S. Hidaka, S. Kobayashi, A. Guedes, A. Malho Guedes, A. Pinho, A. Fragoso, A. Cruz, P. Mendes, E. Morgado, I. Bexiga, A. P. Silva, P. Neves, N. Oyake, K. Suzuki, S. Itoh, S. Yano, K. Turkmen, H. Kayikcioglu, O. Ozbek, M. Saglam, A. Toker, H. Z. Tonbul, S. Gelev, L. Trajceska, E. Srbinovska, S. Pavleska, V. Amitov, G. Selim, P. Dzekova, A. Sikole, H. Bouarich, S. Lopez, C. Alvarez, I. Arribas, P. DE Sequera, D. Rodriguez, S. Tanaka, T. Kanemitsu, M. Sugahara, M. Kobayashi, L. Uchida, Y. Ishimoto, N. Kotera, S. Tanimoto, K. Tanabe, K. Hara, T. Sugimoto, N. Mise, B. Goldstein, M. Turakhia, C. Arce, W. Winkelmayer, B. E.-D. Zayed, K. Said, M. Nishimura, Y. Okamoto, T. Tokoro, M. Nishida, T. Hashimoto, N. Iwamoto, H. Takahashi, T. Ono, N. Sato, J. Raimann, L. A. Usvyat, J. Sands, N. W. Levin, P. Kotanko, M. Iwasaki, N. Joki, Y. Tanaka, N. Ikeda, T. Hayashi, S. Kubo, T.-A. Imamura, Y. Takahashi, K. Hirahata, Y. Imamura, H. Hase, K. Claes, B. Meijers, B. Bammens, D. Kuypers, M. Naesens, Y. Vanrenterghem, P. Evenepoel, G. Boscutti, L. Calabresi, M. Bosco, S. Simonelli, E. Boer, C. Vitali, M. Martone, P. L. Mattei, G. Franceschini, E. Baligh, E. El-Shafey, A. Ezaat, A. Zawada, K. Rogacev, B. Hummel, O. Grun, A. Friedrich, B. Rotter, P. Winter, J. Geisel, D. Fliser, G. H. Heine, J.-I. Makino, K.-S. Makino, T. Ito, S. Genovesi, A. Santoro, P. Fabbrini, E. Rossi, D. Pogliani, A. Stella, G. Bonforte, G. Remuzzi, S. Bertoli, C. Pozzi, S. Pasquali, L. Cagnoli, F. Conte, I. Buzadzic, J. Tosic, N. Dimkovic, Z. Djuric, J. Popovic, I. Pejin Grubisa, N. Barjaktarevic, A. DI Napoli, D. DI Lallo, M. F. Salvatori, F. Franco, S. Chicca, G. Guasticchi, M. Onofriescu, S. Hogas, V. Luminita, A. Mugurel, V. Gabriel, F. Laura, M. Irina, C. Adrian, E. Bosch, E. Baamonde, C. Culebras, G. Perez, B. El Hayek, J. I. Ramirez, A. Ramirez, C. Garcia, M. Lago, A. Toledo, M. D. Checa, T. Taira, T. Hirano, K. Nohtomi, T. Hyodo, T. Chiba, A. Saito, Y. K. Kim, E. J. Choi, C. W. Yang, Y.-S. Kim, P. S. Lim, W. Ming Ying, J. Ya-Chung, I. Zaripova, I. Kayukov, A. Essaian, A. Nimgirova, H. Young, M. Dungey, E. L. Watson, R. Baines, J. O. Burton, A. C. Smith, K. Yamazaki, M. Bossola, L. Colacicco, D. Scribano, C. Vulpio, L. Tazza, T. Okada, N. Okada, I. Michibata, T. Yura, N. Montero, M. Soler, M. Pascual, C. Barrios, E. Marquez, E. Rodriguez, M. A. Orfila, H. Cao, E. Arcos, J. Comas, J. Pascual, M. Ferrario, F. Garzotto, T. Sironi, S. Monacizzo, F. Basso, D. N. Cruz, U. Moissl, C. Tetta, M. G. Signorini, S. Cerutti, C. Ronco, I. Mostovaya, M. Grooteman, M. Van den Dorpel, L. Penne, N. Van der Weerd, A. Mazairac, C. Den Hoedt, R. Levesque, M. Nube, P. Ter Wee, M. Bots, P. Blankestijn, J. Liu, K. L. MA, X. Zhang, B. C. Liu, I.-D. Vladu, R. Mustafa, D. Cana-Ruiu, C. Vaduva, C. Grauntanu, E. Mota, R. Singh, N. Abbasian, C. Stover, N. Brunskill, J. Burton, K. Herbert, A. Bevington, M. Wu, R.-N. Tang, M. Gao, H. Liu, L. Chen, L.-L. LV, B.-C. Liu, M. Nikodimopoulou, S. Liakos, S. Kapoulas, C. Karvounis, D. Fedak, M. Kuzniewski, D. Paulina, B. Kusnierz-Cabala, M. Kapusta, B. Solnica, A. Junque, E. S. Vicent, L. Moreno, M. Fulquet, V. Duarte, A. Saurina, M. Pou, J. Macias, M. Lavado, M. Ramirez de Arellano, M. Ryuzaki, H. Nakamoto, S. Kinoshita, E. Kobayashi, C. Takimoto, T. Shishido, G. Enia, C. Torino, R. Tripepi, V. Panuccio, M. Postorino, A. Clementi, M. Garozzo, G. Bonanno, R. Boito, G. Natale, T. Cicchetti, A. Chippari, D. Logozzo, G. Alati, S. Cassani, A. Sellaro, C. Zoccali, B. Quiroga, E. Verde, S. Abad, A. Vega, M. Goicoechea, J. Reque, J. M. Lopez-Gomez, J. Luno, C. Cabre Menendez, V. Moles, J. P. Vives, D. Villa, J. Vinas, T. Compte, M. Arruche, C. Diaz, J. Soler, J. Aguilera, A. Martinez Vea, A. De Mauri, P. David, M. M. Conte, D. Chiarinotti, C. E. Ruva, M. De Leo, A.-S. Bargnoux, M. Morena, I. Jaussent, L. Chalabi, P. Bories, J.-J. Dion, P. Henri, M. Delage, A.-M. Dupuy, S. Badiou, B. Canaud, J.-P. Cristol, E. Sironi, F. Pieruzzi, E. Galbiati, M. R. Vigano, S. Anpalakhan, S. Rocha, N. Chitalia, R. Sharma, J. C. Kaski, J. Chambers, D. Goldsmith, D. Banerjee, V. Cernaro, A. Lacquaniti, R. Lupica, S. Lucisano, M. R. Fazio, V. Donato, M. Buemi, I. Segalen, U. Vinsonneau, T. Tanquerel, G. Quiniou, Y. Le Meur, E. Seibert, M. Girndt, K. Zohles, C. Ulrich, A. Kluttig, S. Nuding, C. Swenne, J. Kors, K. Werdan, R. Fiedler, N. C. Van der Weerd, M. P. Grooteman, M. A. Van den Dorpel, M. J. Nube, J. Wetzels, D. W. Swinkels, P. M. Ter Wee, A. Khandekar, J. Khandge, J. E. Lee, S. J. Moon, K. H. Choi, H. Y. Lee, B. S. Kim, E. Tuaillon, A. Rodriguez, L. Chenine, J.-P. Vendrell, Y.-M. Sue, C.-H. Tang, Y.-C. Chen, P. Segura, M. J. Garcia Cortes, J. M. Gil, M. M. Biechy, D. Poulikakos, A. Shah, M. Persson, P. Dattolo, M. Amidone, S. Michelassi, L. Moriconi, G. Betti, P. Conti, A. Rosati, A. Mannarino, V. Panichi, F. Pizzarelli, K. Klejna, B. Naumnik, E. Koc-Zorawska, M. Mysliwiec, S. Dimitrie, H. Simona, O. Mihaela, O. Gabriela, S. Radu, P. Octavian, H. Akdam, H. Akar, Y. Yenicerioglu, O. Kucuk, I. Kurt Omurlu, S. Thambiah, R. Roplekar, P. Manghat, I. Fogelman, W. Fraser, G. Hampson, E. Likaj, G. Caco, S. Seferi, M. Rroji, M. Barbullushi, N. Thereska, A. Serban, V. Carmen, S. Cristian, L. Silvia, and A. Covic

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Intensive care medicine, business
Published
2012

10. A Pathophysiological Overview of Dialysis Hypotension

Author

T. Cerrai, Quirino Maggiore, Gualtiero Pelosi, Pietro Dattolo, Marcello Piacenti, Maria Aurora Morales, and F. Pizzarelli

Subjects
medicine.medical_specialty, Dialysis hypotension, business.industry, Internal medicine, medicine, MEDLINE, Cardiology, Intensive care medicine, business
Published
2015

12. Long-Term Urinary Acidification in Phosphatic Urolithiasis

Author

F. Pizzarelli and M. Peacock

Subjects
medicine.medical_specialty, chemistry.chemical_compound, chemistry, Struvite, business.industry, Urinary system, Urology, medicine, MEDLINE, Retrospective cohort study, business, Term (time)
Published
2015

13. Clinical pathological correlates of renal biopsy in elderly patients

Author

Giuseppe Ferro, S. Michelassi, F. Pizzarelli, P. Dattolo, and S. Nigrelli

Subjects
Adult, Male, Nephrology, medicine.medical_specialty, Population, Blood Pressure, Kidney, Internal medicine, Biopsy, medicine, Humans, Minimal change disease, education, Aged, Retrospective Studies, education.field_of_study, medicine.diagnostic_test, business.industry, Biopsy, Needle, Age Factors, General Medicine, Middle Aged, medicine.disease, Surgery, Proteinuria, medicine.anatomical_structure, Creatinine, Female, Kidney Diseases, Renal biopsy, business, Nephrotic syndrome, Kidney disease
Abstract

Background: Reports have shown that well-defined histological patterns do not always correspond to equally clear clinical pictures, particularly so in elderly patients. Methods: With the aim of assessing clinicopathological correlations in the population aged > 65 years with that of lower age, we retrospectively analyzed computerized records of renal needle biopsies consecutively performed in the decade 1991 - 2000 in our unit. Results: Among the 392 eligible subjects, there were 150 patients 65 years of age and more, 76 of whom were over 70. The average serum creatinine was 2.9 mg/dl, with values > 3.5 mg/dl in 25% of cases. The major indication to biopsy was nephrotic syndrome followed by chronic renal failure both in the young adult and the elderly population. The rapidly progressive form led more often to renal biopsy in the elderly patients, and the different prevalence was statistically significant (p < 0.05), as was the higher prevalence of urinary anomalies in the young-adult population. Regarding renal histology, the crescentic neerotizing forms were significantly more frequent in the elderly patients, while IgAN, minimal change disease and SLE predominate in young adults. The most relevant result is the greater prevalence of crescentic necrotizing glomerulonephritis in elderly patients, not only in the cases presenting clinically as rapidly progressive renal failure and acute renal failure, but also in those with the clinical picture of chronic renal failure. Conclusions: Re-evaluation of our case files verifies the importance of the bioptic approach in selected. cases with stages 3-4 chronic kidney damage. This holds true especially for elderly patients.

Published
2006

14. Contents, Vol. 63, 1993

Author

F. Tricot, D. Krzemień, J.V. Tovar, Naoki Fujitsuka, S.C. Tiwari, F. Prospert, Takako Yokozawa, L.A. Sirwal, Antonio Soto, Marie-Paule Ramée, Kazuharu lenaga, N. Belovezhdov, R. Dell’Aquila, M.J. Richard, M. Espinosa, R. Enriquez, A. Mouneimne, Ikuko Hayashi, J. Ortuño, R. Čuiairanović, F. Pizzarelli, R. Saxena, Noriyuki Tatemichi, Q. Maggiore, M. Tanvir, E. Jansson, J. Lacueva, G.H. Malik, Francisco J. Pérez Fontán, Esmeray Acartürk, A. Dhondt, S. Nomura, Richard E. Schell, B.M. Jones, D. Castillo, D. Mittal, T. Kokawa, M.A. Waterloos, V. Stefanović, Pierre Simon, M. Esbjörnsson, Michelle Barnett, Bruno Basolo, M. Bogićević, J.C. Castaño, Kazuharu Ienaga, Giuseppe Piccoli, Chikao Yasunaga, Tomoko Yazawa, S.C. Dash, D. Cordonnier, M.S. Najar, Masaaki Takano, V. Minkova, T. Jogestrand, Caje Moniz, S.K. Agarwal, Bernard F. Jones, Ian R. Rifkin, V. Jacobs, Atsushi Aikawa, R. Vanholder, M. Rivera, M.C. Denis, P. Aljama, Toshimitsu Niwa, Rafael Bárcena, Ko Nakamura, F. Fabrizi, E. Niembro, Kyoichi Kobashi, Chiou-Chyn Lin, Tung-Po Huang, M. Altaf, R. Perez, Antonio Zea, C. Zoccali, K. Yasunaga, Tsukasa Kanazawa, G. Decaux, Lg. Burdiel, Teruaki Akao, Eiisa Menegatti, S. Saxena, Francisco Mampaso, Joanne T Marsden, Ana Gonzalo, Victor Parsons, Micheline Levy, Takashi Yasuda, Teruhiko Maeba, S.K. Pehrsson, S. Ringoir, M. Postorino, Bernard Mattlinger, J.L. Teruel, P. Benito, Chikako Shiba, Akira Hasegawa, Saime Paydas, Laure-Hélène Noël, C. Gonzalez, Shigeru Owada, G. Curatola, J.A. Ruiz, Dianne Baldwin, Masashi Ishida, Phil Tuso, Yutaka Emoto, Tomoyuki Katsuzak, S.N. Mehta, Takehiro Ohara, Dario Roccatello, A. Davenport, Ching-Yuang Lin, N. Van Landschoot, Masao Hattori, N. Veys, I.K.P. Cheng, Joaquín Ortuño, Elizabeth Ball, Hikokichi Oura, W. Van Biesen, M. Mitić, J.B. Cabezuelo, Miguel Pérez Fontán, A. Martin-Malo, B. Namias, A.R. Reshi, Makoto Sugiyama, Ana Rodríguez-Carmona, Monique Menault, Philippe Lesavre, A. Soupart, A. Shouzu, M. Nishikawa, Donald Nortman, I. Altunkova, P. Vlahović, Kenji Maeda, K. Sirajeddine, Cristiana Rollino, Sonoo Mizuiri, Jw. Naskalski, Takashi Miyazaki, L.-E. Lins, N. Clyne, Donald E. Potter, Nan Chen, Sadanobu Ozawa, G. Garcia Otero, Francisco Pombo, and R. Penninckx

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1993

15. Paired hemodiafiltration

Author

F, Pizzarelli

Subjects
Europe, Humans, Hemodiafiltration, Acetates, beta 2-Microglobulin, Online Systems, Hemodialysis Solutions
Abstract

The feasibility of obtaining low-cost high-quality online reinjection fluids was fi rst explored almost 30 years ago, but regulatory conservatism delayed adoption of the technique for almost 20 years. Online treatments are now commonplace in Europe. The competitive advantages of this treatment modality compared to standard convective treatments include lower costs, better quality assurance, a lower environmental burden and better clinical outcomes. The very high volumes of re-infusion fluids peculiar to online treatment allow a better removal of beta2-microglobulin, and there are claims that survival and anemia are better improved by online treatments than by standard convective treatments. In contrast, the acetate burden and its attendant potential hazards are relevant in patients under online treatment, given the considerable quantity of dialysis fluid injected. Acetate-free paired hemodiafiltration, a new online technique, may further ameliorate performances and clinical outcomes, and may actually cut the gordian knot of the safety of online treatments owing to the implemented safeguards.

Published
2007

16. [From dialysate temperature to thermal balance]

Author

F, Pizzarelli

Subjects
Cardiovascular Physiological Phenomena, Renal Dialysis, Dialysis Solutions, Temperature, Humans, Body Temperature
Abstract

The observations concerning the role of temperature in cardiovascular (CV) stability date back to the early 1980s. Since then, many studies have corroborated the original findings on the hemodynamic benefits of what is known as 'cold' as opposed to 'warm' or standard hemodialysis (HD). While the assumptions and conclusions remain fully valid, more recent experience has led to a review of the way the treatments have been defined. The fact that the patient gains or loses heat is not only the consequence of dialysis fluid temperature, but is the result of the interrelationships between dialysis-related factors and patient characteristics. Among the former, blood flow, arterovenous temperature difference in the extracorporeal blood, length and layout of the hematic lines, environmental temperature, and a possible cytokine-mediated pyrogenic effect are all factors that, directly or indirectly, can decisively influence the thermal balance of the dialysis session. Among the latter, the greater the ultrafiltration (UF) rate the greater the buildup of body heat. Finally, there is a considerable variability in body temperature within and between individual uremic patients, and it is especially the subgroup of hypothermic patients who benefit from cold dialysis. These considerations have led to the conclusion that the thermal balance of the dialytic treatment should be tailored to the specific characteristics of the patient and should be adjusted automatically in the course of the dialytic treatment. On these grounds, it is preferable to define thermal variations induced by HD based on physiological effects induced in the patient. Therefore, dialytic treatments can be defined as isothermic, hypo or hyperthermic, depending on the variations in body temperature produced. Isothermic HD combines better benefits in terms of CV stability with fewer unwanted side effects. There are several commonly used therapies of symptomatic hypotension, but they have not been directly compared in the same group of patients. Comparison studies could offer a rational and a most effective approach to treating symptomatic hypotension.

Published
2006

17. [On-line hemodiafiltration without acetate]

Author

F, Pizzarelli, T, Cerrai, G, Ferro, and P, Dattolo

Subjects
Male, Random Allocation, Humans, Female, Pilot Projects, Hemodiafiltration, Acetates, Middle Aged
Abstract

The suitably filtered dialysate which is currently reinfused during on-line hemodiafiltration (HDF-OL) contains bicarbonate and small doses of acetate. The trend of acetataemia During "forced" convective treatments has never been studied. The gain in acetate secondary to the considerable quantities of fluids infused might have clinical significance in relation to the well-known side effects of this anion.In this pilot study 12 patients underwent HDF-OL with reinfusion in predilution of 40 L of substitution fluids containing or not 3 mmol/L of acetate. Apart from this variable, all the other treatment parameters were the same in both procedures. The treatments were carried out in two short consecutive intervals in a random sequence.During HDF-OL the use of dialysate containing small doses of acetate is associated with levels of acetataemia 5-6 times higher compared to the basal. HDF-OL without acetate cancels out this increase. The acetate gained by the patients is significant, on average 75 mmol, and accounts for over 1/3 of the global base gain. Consequently, the bicarbonataemia levels at the end of treatment are significantly higher in HDF-OL with acetate than in the treatment without. Two hours after the end of the treatments the IL-6 levels tend to grow in both methods, but numerically less in HDF-OL without acetate; the difference verges on meaningfulness.The acetate gain is significant during forced convective treatments carried out with standard dialysate. This acetate gain can trigger cytokinin activation. These events are cancelled out by eliminating the acetate from the dialysate. The absence of this anion will be compensated with appropriate increases in the concentration of bicarbonate in the dialysis fluid.

Published
2005

19. Guidelines on water and solutions for dialysis. Italian Society of Nephrology

Author

S, Alloatti, P, Bolasco, C, Canavese, G, Cappelli, L, Pedrini, F, Pizzarelli, G, Pontoriero, A, Santoro, P, Anastasio, U, Teatini, and G, Fuiano

Subjects
Quality Control, National Society of Nephrology, Italian Guidelines, dialysis fluids, Water Pollution, Colony Count, Microbial, Ultrafiltration, Hemodialysis Solutions, Water Purification, Disinfection, Italy, Water Supply, Water Microbiology, Water Pollutants, Chemical
Abstract

The National Society of Nephrology has promoted the development of specific Italian Guidelines for dialysis fluids. Two previous national inquiries showed a wide variety in the type and frequency of both microbiological and chemical controls concerning dialysis water, reinforcing the need for specific standards and recommendations. An optimal water treatment system should include tap water pre-treatment and a double reverse osmosis process. Every component of the system, including the delivery of the treated water to the dialysis machines, should prevent microbiological contamination of the fluid. Regular chemical and microbiological tests and regular disinfection of the system are necessary. 1. Chemical quality (Table: see text). Treated tap water used to prepare dialysis fluid should be within European Pharmacopoeia limits at the water treatment system inlet and at the reverse osmosis outlet. In addition dialysate, concentrate and infusion fluids must comply with specific Pharmacopoeia limits. The physician in charge of the dialysis unit is advised to institute a multidisciplinary team to evaluate the requirement for added chemical controls in the presence of local hazards. 2. Microbiological quality (Table: see text). High microbiological purity of dialysis fluid--regularly verified--is a fundamental prerequisite for dialysis quality and every dialysis unit should aim as a matter of course to obtain "ultra-pure" dialysate (microbial count0.1 UFC/mL, endotoxins0.03 U/mL). On-line dialysate ultrafiltration and regular disinfection of dialysis machines greatly enhance microbiological purity. On-line dialysate reinfusion requires specific devices used according to corresponding instructions and to more frequent microbiological tests. Dialysis fluids for home dialysis should comply with the same chemical and bacteriological quality. The appendix reports the water treatment system's technical characteristics, sampling and analytical methods, monitoring time-tables, as well as the origin and effects of the main toxic substances. Suggestions and questions concerning these guidelines are welcome to nefrologia@sin-italy.org.

Published
2005

20. Quantitative assessment of myocardial echographic response in chronic uremia

Author

Marcello Piacenti, Gualtiero Pelosi, F. Pizzarelli, A Distante, Antonio Benassi, E.M. Ferdeghini, Maria Aurora Morales, and Quirino Maggiore

Subjects
medicine.medical_specialty, Left ventricle hypertrophy, business.industry, Chronic uremia, Maintenance hemodialysis, Interstitial fibrosis, Muscle hypertrophy, Normal renal function, Internal medicine, medicine, Cardiology, Quantitative assessment, Statistical analysis, business
Abstract

Statistical analysis can provide objective, quantitative informations on both the tonal behavior and the underlying texture of conventional 2-D echocardiograms. In this respect, the myocardium of chronic uremic patients is of special interest. Its histologic pattern, characterized by interstitial fibrosis, as well as by deposits of different substances (calcium, aluminum, collagen) within the fibers, yields abnormal echoreflectivity, qualitatively described by conventional ultrasonic examinations, and hypertrophy. Thirty-one patients under maintenance hemodialysis treatment underwent 2-D echocardiography at the end of the dialytic procedure. Sixteen patients with systemic hypertension, comparable left ventricle hypertrophy and normal renal function served as control group. After digitization of the images obtained from a 4-chamber apical view, statistical analyses were performed on regions of interest localized within the interventricular septa. Various first order parameters significantly discriminated the two groups (p >

Published
2002

22. Clinical perspectives of on-line haemodiafiltration

Author

F Pizzarelli and Q Maggiore

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Dialysis fluid, Medicine, Humans, Hemodiafiltration, Line (text file), business, Intensive care medicine, Online Systems
Published
1998

27. Omega-3 and Renal Function in Older Adults

Author

F., Lauretani, primary, M., Maggio, additional, F., Pizzarelli, additional, S., Michelassi, additional, C., Ruggiero, additional, P., Ceda, additional, S., Bandinelli, additional, and L., Ferrucci, additional

Published
2009
Full Text
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29. Subject Index, Vol. 63, 1993

Author

Lg. Burdiel, Chikao Yasunaga, C. Zoccali, V. Minkova, F. Tricot, G. Decaux, V. Jacobs, A.R. Reshi, Ana Gonzalo, S. Ringoir, F. Fabrizi, M. Rivera, M.J. Richard, Philippe Lesavre, S.K. Pehrsson, Micheline Levy, Ikuko Hayashi, Yutaka Emoto, M. Postorino, Laure-Hélène Noël, Esmeray Acartürk, S.C. Tiwari, Caje Moniz, C. Gonzalez, J. Ortuño, W. Van Biesen, A. Mouneimne, Pierre Simon, Phil Tuso, B. Namias, R. Saxena, J. Lacueva, Francisco J. Pérez Fontán, A. Shouzu, Masashi Ishida, M. Tanvir, J.V. Tovar, J.B. Cabezuelo, Miguel Pérez Fontán, Ana Rodríguez-Carmona, Bernard Mattlinger, T. Jogestrand, A. Davenport, M. Bogićević, L.-E. Lins, Donald E. Potter, Ching-Yuang Lin, Richard E. Schell, B.M. Jones, Joanne T Marsden, Takashi Yasuda, Atsushi Aikawa, G. Curatola, J.A. Ruiz, S.C. Dash, F. Prospert, M.S. Najar, Eiisa Menegatti, P. Aljama, M.A. Waterloos, Francisco Mampaso, Monique Menault, Marie-Paule Ramée, Nan Chen, D. Krzemień, Victor Parsons, Bernard F. Jones, Kenji Maeda, R. Vanholder, Kazuharu lenaga, M. Esbjörnsson, E. Jansson, V. Stefanović, Akira Hasegawa, J.L. Teruel, Q. Maggiore, S.N. Mehta, F. Pizzarelli, J.C. Castaño, Giuseppe Piccoli, Sadanobu Ozawa, M. Altaf, Chiou-Chyn Lin, Sonoo Mizuiri, R. Enriquez, S. Nomura, Teruaki Akao, M. Nishikawa, Donald Nortman, Kazuharu Ienaga, K. Sirajeddine, Masaaki Takano, Michelle Barnett, G.H. Malik, Tomoyuki Katsuzak, Tomoko Yazawa, A. Dhondt, L.A. Sirwal, D. Mittal, Rafael Bárcena, D. Cordonnier, I.K.P. Cheng, Hikokichi Oura, E. Niembro, Naoki Fujitsuka, Ko Nakamura, M.C. Denis, M. Mitić, D. Castillo, Takehiro Ohara, Dario Roccatello, M. Espinosa, N. Belovezhdov, Cristiana Rollino, T. Kokawa, R. Čuiairanović, Joaquín Ortuño, Elizabeth Ball, Noriyuki Tatemichi, S.K. Agarwal, Ian R. Rifkin, Tung-Po Huang, Chikako Shiba, Takako Yokozawa, Antonio Soto, R. Dell’Aquila, Tsukasa Kanazawa, Toshimitsu Niwa, Bruno Basolo, R. Penninckx, K. Yasunaga, R. Perez, N. Clyne, I. Altunkova, P. Vlahović, N. Van Landschoot, Masao Hattori, N. Veys, Teruhiko Maeba, Makoto Sugiyama, A. Soupart, Saime Paydas, G. Garcia Otero, Dianne Baldwin, Kyoichi Kobashi, A. Martin-Malo, Jw. Naskalski, Takashi Miyazaki, Francisco Pombo, S. Saxena, P. Benito, Shigeru Owada, and Antonio Zea

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1993

30. Reply by author

Author

Quirino Maggiore, S. Michelassi, Anna Linda Zignego, T. Cerrai, F. Pizzarelli, M. Lombardi, and Pietro Dattolo

Subjects
Transplantation, Nephrology, business.industry, Medicine, business, Virology, Dialysis tubing
Published
1995

31. Influence of blood temperature on vascular stability during hemodialysis and isolated ultrafiltration

Author

Q, Maggiore, F, Pizzarelli, C, Zoccali, S, Sisca, and F, Nicolò

Subjects
Adult, Male, Blood, Renal Dialysis, Hypertension, Hemodynamics, Temperature, Humans, Ultrafiltration, Female, Middle Aged, Body Temperature Regulation
Abstract

We tested the hypothesis that differing temperature (T) changes in extracorporeal blood circuit might partly account for the difference in vascular stability (VS) between isolated ultrafiltration (UF) and simultaneous UF-hemodialysis (HD). The study was carried out in 6 patients who presented frequent episodes of symptomatic hypotension during the routine dialytic sessions. During simultaneous UF-HD with dialysate T set at 37.5 degrees C (standard HD), blood reentered the patients with a T of about 2 degrees C higher, whereas during isolated UF (standard UF) 2 degrees C lower, than at its exit. These extracorporeal blood T changes were reciprocated by warming the venous line in isolated UF (warm UF) and by setting the dialysate at 34.5 degrees C in simultaneous UF-HD (cold HD). During warm UF mean arterial pressure (MAP) fell and heart rate (HR) increased nearly as much as during standard HD. Vice versa, during cold HD MAP and HR remained nearly as stable as during standard UF. It is concluded that the T changes in blood flowing through the extracorporeal circuit largely account for the differing VS between isolated UF and simultaneous UF-HD.

Published
1985

32. Blood temperature and cardiovascular stability in hemofiltration

Author

F, Pizzarelli, S, Sisca, C, Zoccali, S, Parlongo, F, Nicolò, G, Creazzo, D, Delfino, and Q, Maggiore

Subjects
Male, Blood, Heart Rate, Renal Dialysis, Temperature, Humans, Kidney Failure, Chronic, Ultrafiltration, Blood Pressure, Female, Middle Aged, Body Temperature
Abstract

Temperature (T) changes in the blood flowing through the extracorporeal circuit markedly affect cardiovascular tolerance to fluid removal during either hemodialysis (HD) and isolated ultrafiltration. In this study we investigated the effect of blood T changes during postdilutional hemofiltration (HF). To this purpose we compared the changes in mean arterial pressure (MAP) and heart rate (HR) during HF and HD carried out at equivalent T of blood in the venous segment of the extracorporeal circuit. Results show that HF entails some heat loss from blood flowing in the extracorporeal circuit; if heat loss is made similar, HD affords nearly as much blood pressure protection as HF does. On the other hand at equivalent heat gain, HF causes nearly as much hypotension as HD does. We conclude that blood T changes in the extracorporeal circuit affect vascular stability (VS) even in HF. The marginal benefit of HF over HD, still observed at equalized T changes, remains to be elucidated.

Published
1983

36. Transient Hypercalciuria During Acute Pyelonephritis and Active Stone Formation

Author

F. Pizzarelli, Q. Maggiore, and Ciccarelli C

Subjects
medicine.medical_specialty, Kidney, Stone formation, business.industry, Urinary system, Urology, Calcium oxalate, chemistry.chemical_element, Urine, Calcium, urologic and male genital diseases, medicine.disease, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Renal physiology, medicine, Hypercalciuria, business
Abstract

In 1939 Flocks1 reported that “apparently a slight or intermittent obstruction…… in the urinary tract, such as the presence of a small stone in the kidney pelvis, was associated with a significantly higher calcium concentration in the urine from that kidney”, Hennemann et al2 suggested that urinary tract infection might cause hypercalciuria through an impairment of the tubular reabsorption of calcium. These hypotheses have never been tested and idiopathic hypercalciuria is currently regarded as being due to increased absorption of calcium from the gut and/or reduced tubular reabsorption of calcium of unknown cause3. This paper describes a patient who manifested transient renal hypercalciuria concomitantly with episodes of urinary tract infection and multiple stone formation. This association suggests that pyelonephritis and/or partial urinary obstruction due to stone growth may play a role in the genesis of hypercalciuria.

Published
1985

37. The effect of dialysate temperature on haemodialysis leucopenia

Author

G, Enia, C, Catalano, F, Pizzarelli, G, Creazzo, F, Zaccuri, A, Mundo, D, Iellamo, and Q, Maggiore

Subjects
Adult, Male, Renal Dialysis, Temperature, Humans, Leukopenia, Middle Aged
Abstract

We assessed the influence of dialysate temperature on intra-dialytic leucopenia. Lowering dialysate temperature from 38 degrees C to 20.5 degrees C caused a decrease in the dialysis associated white blood cell reduction from 82 +/- 6 per cent to 32 +/- 19 per cent. The degree of leucopenia bore a highly significant relationship with dialyser blood temperature suggesting that a further lowering of blood temperature (to about 20 degrees C) would almost entirely prevent intra-dialytic leucopenia.

Published
1985

38. Long-term urinary acidification in phosphatic urolithiasis

Author

F, Pizzarelli and M, Peacock

Subjects
Adult, Calcium Phosphates, Male, Calcium Oxalate, Struvite, Magnesium Compounds, Hydrogen-Ion Concentration, Middle Aged, Phosphates, Ammonium Sulfate, Recurrence, Humans, Female, Magnesium, Urinary Calculi, Retrospective Studies
Published
1987

39. Vascular stability and heat in dialysis patients

Author

Q, Maggiore, F, Pizzarelli, S, Sisca, C, Catalano, and D, Delfino

Subjects
Blood, Renal Dialysis, Hemodynamics, Temperature, Humans, Ultrafiltration, Hypotension, Body Temperature
Published
1984

42. Hepatitis B vaccination in dialysis patients and nutritional status

Author

Sisca S, S. Michelassi, P. Di Geronimo, A. Alecci, S. Nigrelli, M. Righi, T. Cerrai, F. Pizzarelli, Quirino Maggiore, M. Lombardi, and Pietro Dattolo

Subjects
Adult, Male, Viral Hepatitis Vaccines, Hepatitis B virus, medicine.medical_specialty, medicine.medical_treatment, Nutritional Status, medicine.disease_cause, Dialysis patients, Renal Dialysis, Internal medicine, medicine, Humans, Hepatitis B Vaccines, Hepatitis B Antibodies, Seroconversion, Dialysis, Aged, Uremia, biology, business.industry, virus diseases, Middle Aged, Hepatitis B, biology.organism_classification, digestive system diseases, Vaccination, Titer, Hepadnaviridae, Immunology, Female, Hemodialysis, business
Abstract

35 dialysis patients underwent anti-HBV vaccination. We classified patients in responders or non-responders using an anti-HBs titer of 50 UI/l as the discriminating serum level and tried to assess whether the antibody response bears any relationship with the nutritional status. 26 patients (74%) reached the target atb titer, which was maintained during follow-up (average 360 UI/l). The weak response in the other 9, with values never exceeding 20 UI/l, was short-lived. Anthropometric and impedenziometric parameters were higher in responders than in nonresponders, but the difference did not reach statistical significance. We conclude that the atb titer which discriminates uremics in responders or not must be greater than 50 UI/l and that the nutritional status may interfere with the seroconversion rate, but this conclusion needs to be validated in a wider population.

43. Shared decision making in elderly patients with kidney failure.

Author

Kanbay M, Basile C, Battaglia Y, Mantovani A, Yavuz F, Pizzarelli F, Luyckx VA, Covic A, Liakopoulos V, and Mitra S

Subjects
Humans, Aged, Kidney Failure, Chronic therapy, Renal Insufficiency therapy, Renal Insufficiency etiology, Quality of Life, Renal Dialysis, Decision Making, Shared
Abstract

'Elderly' is most commonly defined as an individual aged 65 years or older. However, this definition fails to account for the differences in genetics, lifestyle and overall health that contribute to significant heterogeneity among the elderly beyond chronological age. As the world population continues to age, the prevalence of chronic diseases, including chronic kidney disease (CKD), is increasing and CKD frequently progresses to kidney failure. Moreover, frailty represents a multidimensional clinical entity highly prevalent in this population, which needs to be adequately assessed to inform and support medical decisions. Selecting the optimal treatment pathway for the elderly and frail kidney failure population, be it haemodialysis, peritoneal dialysis or conservative kidney management, is complex because of the presence of comorbidities associated with low survival rates and impaired quality of life. Management of these patients should involve a multidisciplinary approach including doctors from various specialties, nurses, psychologists, dieticians and physiotherapists. Studies are mostly retrospective and observational, lacking adjustment for confounders or addressing selection and indication biases, making it difficult to use these data to guide treatment decisions. Throughout this review we discuss the difficulty of making a one-size-fits-all recommendation for the clinical needs of older patients with kidney failure. We advocate that a research agenda for optimization of the critical issues we present in this review be implemented. We recommend prospective studies that address these issues, and systematic reviews incorporating the complementary evidence of both observational and interventional studies. Furthermore, we strongly support a shared decision-making process matching evidence with patient preferences to ensure that individualized choices are made regarding dialysis vs conservative kidney management, dialysis modality and optimal vascular access., (© The Author(s) 2023. Published by Oxford University Press on behalf of the ERA.)

Published
2024
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44. Chronic kidney disease in the elderly and frail patient: perspectives with opinions and comments.

Author

Pizzarelli F, Basile C, Aucella F, and Dattolo PC

Subjects
Humans, Aged, Frail Elderly, Quality of Life, Kidney, Geriatric Assessment, Frailty diagnosis, Frailty epidemiology, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic epidemiology, Renal Insufficiency, Chronic therapy
Abstract

Chronic kidney disease is common in elderly and frail people. The importance of age in staging chronic kidney disease is discussed as well as the possible constraints of staging what is actually a 'continuum' of disease progression. Frailty is a biological state characterized by the decline of several physiological systems and strongly correlated with adverse health outcomes, including mortality. Frailty is measured by the Comprehensive Geriatric Assessment, which focuses on quantitative rating scales that determine not only the clinical profile and pathological risk of frail individuals, but also their residual capacities, functional status, and quality of life. There is circumstantial evidence that Comprehensive Geriatric Assessment can improve both survival and quality of life in elderly chronic kidney disease patients. Despite the long list of emerging risk factors and markers of chronic kidney disease progression, it is the authors' opinion that a single biochemical parameter can hardly cover the complexity of chronic kidney disease in elderly and frail patients. Among the numerous clinical scores proposed, the European Renal Best Practice guidelines recommend the Renal Epidemiology and Information Network score and the Kidney Failure Risk Equations. The former provides a reasonable estimate of short-term mortality risk, the latter provides the risk of chronic kidney disease progression. In conclusion, the elderly individual with advanced chronic kidney disease is often comorbid and frail with peculiarities in terms of disease grading, clinical assessment and monitoring. The time has come to reshape the care of this growing number of patients by focusing on multidisciplinary teams both in the hospital and in the community., (© 2023. The Author(s) under exclusive licence to Italian Society of Nephrology.)

Published
2023
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46. Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study "Hephaestus".

Author

Pizzarelli F, Cantaluppi V, Panichi V, Toccafondi A, Ferro G, Farruggio S, Grossini E, Dattolo PC, Miniello V, Migliori M, Grimaldi C, Casani A, Borzumati M, Cusinato S, Capitanini A, Quercia A, Filiberti O, and Dani L

Subjects
Adult, Aged, Aged, 80 and over, Citric Acid, Humans, Middle Aged, Prospective Studies, Renal Dialysis, Hemodiafiltration adverse effects, Interleukin-6
Abstract

Background: Studies addressing the anti-inflammatory properties of citrate dialysate enrolled patients in both hemodialysis (HD) and hemodiafiltration (HDF), the latter not adjusted for adequate convective exchange. This is a potential source of confounding in that HDF itself has anti-inflammatory effects regardless of the buffer, and optimal clinical outcomes are related to the amount of convection., Methods: To distinguish the merits of the buffer from those of convection, we performed a 6-month, prospective, randomized, crossover AB-BA study. Comparisons were made during the 3-month study period of on-line HDF with standard dialysate containing three mmol of acetic acid (OL-HDFst) and the 3-month of OL-HDF with dialysate containing one mmol of citric acid (OL-HDFcit). Primary outcome measure of the study was interleukin-6 (IL-6). Klotho, high sensitivity C-reactive protein (hsCRP), fetuin and routine biochemical parameters were also analyzed., Results: We analyzed 47 patients (mean age 64 years, range 27-84 years) enrolled in 10 participating Nephrology Units. Convective volumes were around 25 L/session with 90 percent of sessions > 20 L and ß2-microglobulin reduction rate 76% in both HDFs. Baseline median IL-6 values in OL-HDFst were 5.6 pg/ml (25:75 interquartile range IQR 2.9:10.6) and in OL-HDFcit 6.6 pg/ml (IQR 3.4:11.4 pg/ml). The difference was not statistically significant (p 0.88). IL-6 values were lower during OL-HDFcit than during OL-HDFst, both when analyzed as the median difference of overall IL-6 values (p 0.02) and as the median of pairwise differences between the baseline and the 3-month time points (p 0.03). The overall hsCRP values too, were lower during OL-HDFcit than during OL-HDFst (p 0.01). Klotho levels showed a time effect (p 0.02) and the increase was significant only during OL-HDFcit (p 0.01)., Conclusions: Citrate buffer modulated IL-6, hsCRP and Klotho levels during high volume OL-HDF. These results are not attributable to differences in the dialysis technology that was applied and may suggest a potential biological effect of citrate on CKD-associated inflammatory state. ClinicalTrials.gov identifier NCT02863016., (© 2021. Italian Society of Nephrology.)

Published
2021
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48. Reducing salt intake by urine chloride self-measurement in non-compliant patients with chronic kidney disease followed in nephrology clinics: a randomized trial.

Author

Panuccio V, Mallamaci F, Pizzini P, Tripepi R, Garofalo C, Parlongo G, Caridi G, Provenzano M, Mafrica A, Simone G, Cutrupi S, D'Arrigo G, Porto G, Tripepi G, Nardellotto A, Meneghel G, Dattolo P, Pizzarelli F, Rapisarda F, Ricchiuto A, Fatuzzo P, Verdesca S, Gallieni M, Gesualdo L, Conte G, Plebani M, and Zoccali C

Abstract

Background: Adherence to low salt diets and control of hypertension remain unmet clinical needs in chronic kidney disease (CKD) patients., Methods: We performed a 6-month multicentre randomized trial in non-compliant patients with CKD followed in nephrology clinics testing the effect of self-measurement of urinary chloride (69 patients) as compared with standard care (69 patients) on two primary outcome measures, adherence to a low sodium (Na) diet (<100 mmol/day) as measured by 24-h urine Na (UNa) excretion and 24-h ambulatory blood pressure (ABPM) monitoring., Results: In the whole sample (N = 138), baseline UNa and 24-h ABPM were143 ± 64 mmol/24 h and 131 ± 18/72 ± 10 mmHg, respectively, and did not differ between the two study arms. Patients in the active arm of the trial used >80% of the chloride strips provided to them at the baseline visit and at follow-up visits. At the third month, UNa was 35 mmol/24 h (95% CI 10.8-58.8 mmol/24 h; P = 0.005) lower in the active arm than the control arm, whereas at 6 months the between-arms difference in UNa decreased and was no longer significant [23 mmol/24 h (95% CI -5.6-50.7); P = 0.11]. The 24-h ABPM changes as well as daytime and night-time BP changes at 3 and 6 months were similar in the two study arms (Month 3, P = 0.69-0.99; Month 6, P = 0.73-0.91). Office BP, the use of antihypertensive drugs, estimated Glomerular Filtration Rate (eGFR) and proteinuria remained unchanged across the trial., Conclusions: The application of self-measurement of urinary chloride to guide adherence to a low salt diet had a modest effect on 24-h UNa and no significant effect on 24-h ABPM., (© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.)

Published
2020
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50. Recommendations for the prevention, mitigation and containment of the emerging SARS-CoV-2 (COVID-19) pandemic in haemodialysis centres.

Author

Basile C, Combe C, Pizzarelli F, Covic A, Davenport A, Kanbay M, Kirmizis D, Schneditz D, van der Sande F, and Mitra S

Subjects
COVID-19, Caregivers, Coronavirus Infections epidemiology, Coronavirus Infections transmission, Equipment Contamination, Hospitals, Isolation, Humans, Patient Care Team, Pneumonia, Viral epidemiology, Pneumonia, Viral transmission, SARS-CoV-2, Betacoronavirus, Coronavirus Infections prevention & control, Pandemics prevention & control, Pneumonia, Viral prevention & control, Renal Dialysis
Abstract

COVID-19, a disease caused by a novel coronavirus, is a major global human threat that has turned into a pandemic. This novel coronavirus has specifically high morbidity in the elderly and in comorbid populations. Uraemic patients on dialysis combine an intrinsic fragility and a very frequent burden of comorbidities with a specific setting in which many patients are repeatedly treated in the same area (haemodialysis centres). Moreover, if infected, the intensity of dialysis requiring specialized resources and staff is further complicated by requirements for isolation, control and prevention, putting healthcare systems under exceptional additional strain. Therefore, all measures to slow if not to eradicate the pandemic and to control unmanageably high incidence rates must be taken very seriously. The aim of the present review of the European Dialysis (EUDIAL) Working Group of ERA-EDTA is to provide recommendations for the prevention, mitigation and containment in haemodialysis centres of the emerging COVID-19 pandemic. The management of patients on dialysis affected by COVID-19 must be carried out according to strict protocols to minimize the risk for other patients and personnel taking care of these patients. Measures of prevention, protection, screening, isolation and distribution have been shown to be efficient in similar settings. They are essential in the management of the pandemic and should be taken in the early stages of the disease., (© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.)

Published
2020
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