1. Evaluation of Cystatin C for the Detection of Chronic Kidney Disease in Cats
- Author
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Sylvie Daminet, Hervé P. Lefebvre, Joris R. Delanghe, B Reynolds, Liesbeth Ghys, Siska Croubels, Evelyne Meyer, and Dominique Paepe
- Subjects
Male ,0301 basic medicine ,CLEARANCE ,Standard Article ,Cat Diseases ,urologic and male genital diseases ,GLOMERULAR-FILTRATION-RATE ,0403 veterinary science ,chemistry.chemical_compound ,Reference Values ,Serum cystatin ,Chronic kidney disease ,Nephrology/Urology ,Medicine ,POPULATION ,education.field_of_study ,CATS ,biology ,04 agricultural and veterinary sciences ,Standard Articles ,female genital diseases and pregnancy complications ,DOGS ,ENDOGENOUS MARKER ,Creatinine ,Female ,Glomerular Filtration Rate ,RENAL-FUNCTION ,medicine.medical_specialty ,040301 veterinary sciences ,Urinary system ,Population ,Urology ,Renal function ,Feline ,03 medical and health sciences ,Nephelometry and Turbidimetry ,Predictive Value of Tests ,Internal medicine ,INITIAL EVALUATION ,Animals ,Cystatin C ,Renal Insufficiency, Chronic ,HEALTHY ,education ,General Veterinary ,business.industry ,FELINE SERUM ,GAMMA-TRACE ,medicine.disease ,030104 developmental biology ,Endocrinology ,chemistry ,Case-Control Studies ,Cats ,biology.protein ,SMALL ANIMAL ,business ,Biomarkers ,Kidney disease - Abstract
Background Serum cystatin C (sCysC) and urinary cystatin C (uCysC) are potential biomarkers for early detection of chronic kidney disease (CKD) in cats. An in-depth clinical validation is required. Objectives To evaluate CysC as a marker for CKD in cats and to compare assay performance of the turbidimetric assay (PETIA) with the previously validated nephelometric assay (PENIA). Animals Ninety cats were included: 49 CKD and 41 healthy cats. Methods Serum CysC and uCysC concentrations were prospectively evaluated in cats with CKD and healthy cats. Based on plasma exo-iohexol clearance test (PexICT), sCysC was evaluated to distinguish normal, borderline, and low GFR. Sensitivity and specificity to detect PexICT
- Published
- 2016
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