149 results on '"FREQUENT"'
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2. أثر القراءات المتواترة في معرفة أحداث السيرة النبوية.
- Author
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أشادي بن أحمد الم and محمد بن عبد الله 
- Abstract
Copyright of University of Sharjah Journal of Sharia & Islamic Studies (JSIS) is the property of University of Sharjah - Scientific Publishing Unit and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
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3. موازنة بين تفسيري الكشف والبيان للإمام الثعلبي والبسيط للإمام الواحدي، من بداية الآية 36 إلى الآية 38 من سورة الأنعام دراسة تطبيقية.
- Author
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عبير سعيد علي الش
- Abstract
Copyright of Arts Magazine is the property of Thamar University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
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4. العطف المفرد المتكرر في القران الكريم (دراسة وفق الحقول الدلالية النحوية ).
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ناصر علي حسين and نافع علوان بهلول
- Abstract
Copyright of Journal of Tikrit University for Humanities is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
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5. Misdiagnosis of Bipolar Disorder: Rare or Frequent?
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Sevda Korkmaz, Murad Atmaca, Gülay Taşcı, and Şuheda Kaya
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bipolar bozukluk ,yanlış tanı ,sıklık ,bipolar disorder ,misdiagnosis ,frequent ,Medicine (General) ,R5-920 - Abstract
Background: As much there have been limited number of studies which have examined misdiagnosis of bipolar disorder, it is so difficult to say that there are enough systematic research to identify the diagnostic rate of bipolar disorder. On the other hand, we did not find any research in Turkey. For this reason, we wondered what is situation in our country in terms of misdiagnosis of bipolar disorder. Methods: The present study was done at xxx University, School of Medicine, Department of Psychiatry. Patients who were from both out-patient and in-patient clinics were included in the study. After a selection process, 171 patients with bipolar disorder were enrolled. In this group of patients, misdiagnosis of bipolar disorder were investigated. Results: 56.14 percent of patients had misdiagnosis of bipolar disorder. The most frequent misdiagnosis was fetermined to be major depressive disorder (in fifty cases, 54.3%). Followings were schizoaffective disorder (in eighteen cases, 24.3%), schizophrenia (in thirteen patients, 24.3%), delusional disorder (in thirteen patients, 24.3%), dysthymic disorder (in ten cases, 15.9%), generalized anxiety disorder ((in ten cases, 15.9%), obsessive compulsive disorder (in seven cases, 12.6%), paranoid personality disorder (in two cases, 4.1%). Conclusions: The results of the study suggest that bipolar disorder is frequently misdiagnosed one and that the most frequent misdagnoses were majör depressive disorder and following psychotic spectrum disorders. Clinicians should be aware of frequent misdiagnosis in patients with bipolar disorder.
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- 2023
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6. Home Haemodialysis in Children
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Hothi, Daljit K., Schmitt, Claus Peter, Warady, Bradley A., editor, Alexander, Steven R., editor, and Schaefer, Franz, editor
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- 2021
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7. Extracting sequential frequent itemsets from probabilistic sequences database
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Seddiki, Imane, Nouioua, Farid, and Barkat, Abdelbasset
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- 2023
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8. A Comparative Clinical study of Mritasanjivan Rasa and Sunthyadi Kwath in the management of Amavata with special reference to Dushivisa
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Kushwaha, Ravi Kr, Sharma, Anita, Porte, Sharad M, Kushwaha, Ravi Kr, Sharma, Anita, and Porte, Sharad M
- Abstract
Amavata vis-a-vis Rheumatioid arthritis occurs worldwide in all races, sexes, age and climates. Rheumatoid Arthritis is a disease of unknown aetiology chiefly affecting the joints along with systemic involvement, resulting in severe disabilities and crippling deformities. The onset is more frequent during 4th and 5th decades of life, with 50% of patients developing the disease between ages of 35 to 50 years with male to female ratio 1:3, although it resembles with Amavata, but still Amavata has self entity. In Present time Amavata ( Rheumatoid arthritis) is a life style disorder which effect the most of the youth generation due to unawareness, fast machinery life and taking so many hazard chemicals (which act as Dushivisha) in food material which causes Mandaagni and produces Ama as a visha. This Ama ac cumulates in the body parts and cause of Amavata (Rheumatoid arthritis) 
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- 2024
9. Efficient High-Utility Itemset Mining Over Variety of Databases: A Survey
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Suvarna, U., Srinivas, Y., Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Nayak, Janmenjoy, editor, Abraham, Ajith, editor, Krishna, B. Murali, editor, Chandra Sekhar, G. T., editor, and Das, Asit Kumar, editor
- Published
- 2019
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10. THE STUDY OF THE BUCKLING PHENOMENON OF INDUSTRIAL RAILWAYS IN THE JIUL VALLEY.
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BRÎNAŞ, ILDIKO
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INDUSTRIAL railroads , *MECHANICAL buckling , *COMPRESSION loads , *BARS (Engineering) , *DEFORMATIONS (Mechanics) - Abstract
The compression load of straight bars, for which the cross-sections are smaller compared to their length, causes a phenomenon of bending along the longitudinal axis. Upon reaching a certain level, called the critical level of the stresses, the bending deformations begin to increase beyond the bearing limit of the bar. It yields instantly, due to an unstable elastic deformation state, although the material's resistance limit has not been exceeded. The irreversibility of the phenomenon is dangerous especially for the railway tracks and is not fully mastered by calculation methods. They can eventually establish the level of the critical demand, which has values specific to each rail configuration. It is accepted that for loads lower than this level, buckling of the respective rail does not occur. The longitudinal tension in the railway tracks occurs due to the expansion caused by their heating under the action of the sun's rays, but also due to the friction between the rails and the train wheels. This paper proposes the realization of a study model of the buckling of the railway tracks. This model is represented by an assembly, built in the SOLIDWORKS application for which a Buckling simulation was made. The imposition of two distinct temperatures on the rails and crossties is the source of the model's request. The increase in the temperature of the component parts of the assembly causes their expansion, so implicitly the appearance of some longitudinal deforming forces, specific to the buckling phenomenon. [ABSTRACT FROM AUTHOR]
- Published
- 2022
11. A trial to address the complex needs of counselling helpline callers.
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Vivekananda, Kitty, Bamford, Helen, Allen, Caroline, Evans, Ann, Woodward, Alan, and Leckie, Suzanne
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HOTLINES (Counseling) , *MENTAL health personnel , *COUNSELING , *STUDENT counselors , *HELPLINES , *TELEPHONE calls - Abstract
Objective: Addressing the complex needs of callers who use helplines frequently has proved challenging for counselling helplines around the world. This paper examines the feasibility and acceptability of a telephone intervention called the Wellbeing Support Program (WSP), designed to address the needs of this group. Methods: A mixed methods approach involving quantitative clinical data and thematic analysis of semi-structured interviews with frequent callers was used to evaluate the Wellbeing Support Program (WSP). Three counsellors from SANE Australia delivered the program and collected non-identifying telephone counselling data between June 2017 and February 2018. Researchers from Monash University undertook 20 semi-structured interviews with 15 participants and conducted analysis of the data. Results: The complex and diverse needs of frequent callers posed challenges for the feasibility of the WSP. However, callers expressed a high level of acceptability with the key features of the WSP including the continuity of care; the opportunity to explore things in greater depth; regularity; reliability; safety; trust; professional competence; and empathy and human connection. Discussion: This research provides valuable insights into the ongoing support needs of people who have experienced early childhood adversity and social disadvantage, highlighting the importance of being person centred and trauma informed. The results identify gaps in a fragmented mental health system and highlight a need to design an advanced model of care that sees General Medical Practitioners, mental health professionals and crisis helplines collaborating to provide an integrated approach to improving outcomes for those in most need. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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12. تدبر سورة الفاحتة من خالل توجيه ما فيها من قراءات.
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Abdullah Shalash, Adnan Moh’d and Al Doumani, Fawaz Farhan
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SCHOLARS ,READING ,AUTHORS - Abstract
Copyright of Ma'alim Quran Sunnah is the property of Universiti Sains Islam Malaysia (USIM) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
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13. القراءات القرآنية في جزء عم من كتاب التفسير في صحيح البخاري، "جمعا وتحقيقا ودراسة ".
- Author
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هيفاء عبد الرؤوف and رياض محمود قاسم
- Subjects
NUMBER theory ,VOCABULARY ,READING - Abstract
Copyright of IUG Journal of Islamic Studies is the property of Islamic University of Gaza and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
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14. Assessment of Frequent Work Related Musculoskeletal Disorders in Patients Visiting the Physiothrapy OPD of Civil Hospital Quetta, Pakistan: A Cross Sectional Survey.
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Ali, Aadil Ameer, Haq, Noman, Hussain, Amjad, Rafique, Muhammad, M. R., Muhammad Ishaque, Ahmad, Taufiq, and Yasmeen, Shabana
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OCCUPATIONAL diseases ,MUSCULOSKELETAL system diseases ,LUMBAR pain ,PHYSICAL therapy ,CROSS-sectional method ,AUDIOLOGY ,SURVEYS ,SOCIOECONOMIC factors ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,DATA analysis software ,STATISTICAL sampling ,NECK ,MEDICAL needs assessment ,OUTPATIENT services in hospitals - Abstract
Background: Work related musculoskeletal disorders (WRMSD) are the sort of disorders which involves soft tissues. The involvement of soft tissues can be due to the over use, restlessness and improper use. The main target of WRMSD are working indicuduals. it may cause muscle strain, ligament strain, tendon strain, tendentious and bursitis. Methods: The cross section survey was conducted and data was collected from July to October 2018 from civil hospital Quetta, Pakistan. A self-constructed proforma was used among the 97 patients who meet the inclusion and exclusion criteria and Spss version 23 was used. Results: The majority (n=49, 50.5%) were belongs to age group of 21 to 35 and were (n=51, 52.6%) were male. In marital status majority (n=64, 66%) were married. In involvement of part majority (n=28, 28.9%) were suffering from lower back problem. After checking the type of injury (n=48, 49.5%) were suffering from muscular strain. In the context of onset of injury majority (N=41, 42.3%) were experienced their problem suddenly. Conclusion: The study finalized that WRMSD is most common in working individuals especially in older and females. The WRMDS puts heavy burden on the society, annually. As the participants who belongs to low socio economic status are more vulnerable for WRMDS. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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15. Ten Years of Frequent Users in an Inner City Emergency Department
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Martin, Gerard B, Stokes-Buzzelli, Stephanie A, Peltzer-Jones, Jennifer M, and Schultz, Lonni R
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Frequent ,patients ,recidivism ,Emergency ,Medicine - Abstract
Introduction:The purpose of this study was to determine if differences could be detected in the presentation patterns and admission rates among frequent emergency department users (FEDU) of an urban emergency department over a 10-year period.Methods: This was an IRB approved, retrospective review of all patients who presented to the ED 5 or more times for 3 distinct time periods: “year 0” 11/98-10/99, “year 5” 11/03–10/04, and “year 10” 11/08–10/9. FEDU were grouped into those with 5–9, 10–14, 15–19, and ≥ 20 visits per year. Variables analyzed included number of visits, disposition, and insurance status. We performed comparisons using Kolmogorov-Smirnov and chi-square tests. A P < 0.05 was considered significant.Results: We found a a 66% increase in FEDU patients over the decade studied, with a significant increase in both the number of FEDU in each visit frequency category over the 3 time periods (P < 0.0001), as well as the total number of visits by each group of FEDU (P < 0.0001). The proportion of FEDU visits for the 5–9 group resulting in admission increased from 25.9% to 29% from year 0 to year 10 (P < 0.001), but not for the other visit groups. In comparing admission rates between FEDU groups, the admission rate for the 5–9 group was significantly higher than the ≥ 20 group for the year 5 time period (P < 0.001) and the year 10 time period (P < 0.001) and showed a similar trend, but not significant, at year 0 (P = 0.052). The overall hospital admission rate for emergency patients over the same time span remained stable at 22-24%. The overall proportion of uninsured FEDU was stable over the decade studied, while the uninsured rate for the overall ED population for the same time periods increased.Conclusion: The results demonstrate the FEDU population is not a homogeneous group of patients. Increased attention to differences among FEDU groups is necessary in order to plan more effective interventions. [West J Emerg Med. 2013;14(3):243–246.]
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- 2013
16. Frequent Pattern Mining on Time and Location Aware Air Quality Data
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Apeksha Aggarwal and Durga Toshniwal
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Air quality ,data mining ,frequent ,itemset ,spatio-temporal ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
With the advent of big data era, enormous volumes of data are generated every second. Varied data processing algorithms and architectures have been proposed in the past to achieve better execution of data mining algorithms. One such algorithm is extracting most frequently occurring patterns from the transactional database. Dependency of transactions on time and location further makes frequent itemset mining task more complex. The present work targets to identify and extract the frequent patterns from such time and location-aware transactional data. Primarily, the spatio-temporal dependency of air quality data is leveraged to find out frequently co-occurring pollutants over several locations of Delhi, the capital city of India. Varied approaches have been proposed in the past to extract frequent patterns efficiently, but this work suggests a generalized approach that can be applied to any numeric spatio-temporal transactional data, including air quality data. Furthermore, a comprehensive description of the algorithm along with a sample running example on air quality dataset is shown in this work. A detailed experimental evaluation is carried out on the synthetically generated datasets, benchmark datasets, and real world datasets. Furthermore, a comparison with spatio-temporal apriori as well as the other state-of-the-art non-apriori-based algorithms is shown. Results suggest that the proposed algorithm outperformed the existing approaches in terms of execution time of algorithm and memory resources.
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- 2019
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17. FREQUENCY AND RISK FACTORS OF FREQUENT EXACERBATIONS OF ASTHMA IN PATIENTS IN A TERTIARY CARE HOSPITAL: A HOSPITAL-BASED COMPARATIVE STUDY
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Asma Chaudhry, Kaleem Ullah Toori, and Sumaira Saleem
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asthma ,anxiety ,blood eosinophilia ,exacerbation ,frequent ,Medicine ,Medicine (General) ,R5-920 - Abstract
Objective: To determine the frequency of recurrent exacerbations in asthma patients and compare the risk factors for frequent and non frequent exacerbations. Study Design: Cross-sectional study. Place and Duration of Study: KRL Hospital Islamabad from Jun to Dec 2016. Patients and Methods: Non-probability technique was used to sample two hundred and eighty one patients.Asthma exacerbations were defined by GINA guidelines. Frequent exacerbations were defined as two or more in the previous year. Data regarding demographics and risk factors were collected. Inhaler technique was checked.BMI and blood eosinophil levels were measured. SPSS 22 was used for data analysis. Results: Out of total 281 patients, frequent asthma exacerbations were observed in 143 (50.9%) patients. Female gender (p=0.00) and lower education (p=0.02) led to frequent exacerbations. Patients education about disease or treatment (p=0.03), URTI (p=0.00), allergen exposure (p=0.00), drug history (p=0.04), treatment step-II (p=0.00), medication non-compliance (p=0.00), incorrect inhaler technique (p=0.01), anxiety (p=0.01), previous ICU admission (p=0.02) and blood eosinophilia (p=0.00) were significantly associated with frequent exacerbations. Of these, independent predictors were patient education (p=0.02), URTI (p=0.00), allergen exposure (p=0.00), drug history (p=0.00), treatment step-II (p=0.03), medication non-compliance (p=0.02), anxiety (p=0.01) and eosinophilia (p=0.00). Conclusion: Majority of our patients underwent frequent exacerbations. Risk factors found to be associated with frequent exacerbations were female gender, lower education, patient unawareness, URTI, allergen and drug exposure, treatment step-II, medication non-compliance, anxiety and blood eosinophilia.
- Published
- 2018
18. Use of Health Information Technology to Manage Frequently Presenting Emergency Department Patients
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Stokes-Buzzelli, Stephanie, Peltzer-jones, Jennifer M, Martin, Gerard B, Ford, Maureen M, and Weise, Andrew
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Frequent ,utilization ,use - Abstract
Objective: To determine if the effective use of Health Information Technologies (HIT) and the Electronic Medical Record (EMR) affects emergency department (ED) usage in a complicated frequently presenting patient population.Methods: A retrospective, observational study of 45 patients enrolled in our Frequent User Program called Community Resources for Emergency Department Overuse (CREDO) between June 2005 and July 2007. The study was conducted at an urban hospital with greater than 95,000 annual visits. Patients served as their own historical controls. In this pre-post study, the pre-intervention control period was determined by the number of months the patient had been enrolled in the program. The pre- and post-intervention time periods were the same for each patient but varied between patients. The intervention included using HIT to identify the most frequently presenting patients and creating individualized care plans for those patients. The care plans were made available through the EMR to all healthcare providers. Study variables in this study intervention included ED charges, lab studies ordered, number of ED visits, length of stay (LOS), and Total Emergency Department Contact Time (TEDCT), which is the product of the number of visits and the LOS. We analyzed these variables using paired T-tests. This study was approved by the institutional review board.Results: Forty-five patients were enrolled, but nine were excluded for no post enrollment visits; thus, statistical analysis was conducted with n=36. The ED charges decreased by 24% from $64,721 to $49,208 (p=0.049). The number of lab studies ordered decreased by 28% from 1847 to 1328 (p=0.04). The average number of ED visits/patient decreased by 25% from 67.4 to 50.5 (p=0.046). The TEDCT decreased by 39% from 443.7 hours to 270.6 hours (p=0.003).Conclusion: In this pre-post analysis of an intervention targeting ED frequent users, the use of HIT and the EMR to identify patients and store easily accessible care plans significantly reduced ED charges, labs ordered, number of ED visits, and the TEDCT. [West J Emerg Med 2010; 11(4):348-353.]
- Published
- 2010
19. A More Efficient Algorithm to Mine Skyline Frequent-Utility Patterns
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Lin, Jerry Chun-Wei, Yang, Lu, Fournier-Viger, Philippe, Dawar, Siddharth, Goyal, Vikram, Sureka, Ashish, Vo, Bay, Kacprzyk, Janusz, Series editor, Pan, Jeng-Shyang, editor, Lin, Jerry Chun-Wei, editor, Wang, Chia-Hung, editor, and Jiang, Xin Hua, editor
- Published
- 2017
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20. Frequent Users of the Emergency Department: Risky Business
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Grover, Casey A and Close, Reb JH
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frequent ,user ,emergency ,department ,risks - Published
- 2009
21. Relevance- and Frequency-Enabled Trip Planning Model Based on Socio-economic Status
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Sesham Anand, Padmanabham P., Govardhan A., and Kulkarni Rajesh
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correlation ,pattern ,socio-economic ,frequent ,trip ,planning ,mining ,Science ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Planning a trip not only depends on the traveling cost, time, and path, but also on the socio-economic status of the traveler. This paper attempts to introduce a new trip planning model that is able to work on real-time data with multiple socio-economic constraints. The proposed trip planning model processes real-time data to extract the relevant socio-economic attributes; later, it mines the most frequent as well as the feasible attributes to plan the trip. The relevance of the socio-economic constraints is defined using correlations, whereas the frequent as well as the feasible attributes are mined through the sequential pattern mining approach. Real-time travel information of about 38,303 trips was acquired from the Indian city of Hyderabad, and the proposed model was subjected to experimentation. The proposed model maintained a substantial trade-off between multiple performance metrics, though the trip mean model performed statistically.
- Published
- 2017
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22. Association between mood disorders and frequent emergency department use: a cross-sectional study
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Fehlmann, Christophe A., Miron-Celis, Marcel, Chen, Yue, Perry, Jeffrey, and Eagles, Debra
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- 2022
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23. The American Indian Culture and Research Journal and The American Indian Quarterly: A Citation Analysis
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Metoyer-Duran, Cheryl
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structural element ,precede ,intellectual issues formalization ,disciplinary validity ,generate scholarly body ,frequent - Abstract
Approximately twenty years ago, American Indian studies programs surfaced in academic institutions in the United States. Some institutions emphasized research, while others focused on teaching, cultural activities, and community service functions. As Russell Thornton explained, the emergence of these programs differed from the histories of most previously existing disciplines. The fundamental difference is that, historically, a discipline came first, followed by its structural component (faculties, courses, and programs). In the case of American Indian studies, the structural element preceded the formalization of intellectual issues. There is still debate over the disciplinary validity of American Indian studies.A standard measure of a discipline is its ability to generate and sustain a scholarly body of literature. Citation analysis is one method for examining and classifying that literature. Citation analysis can examine the scholarly literature emanating from American Indian studies and address questions such as, Who are the most frequently cited authors? Which subject areas receive frequent citation? What are the ages of the most frequently cited works? Which works, including scholarly journals, receive the most citation?
- Published
- 1993
24. Most Frequent Physical Symptoms of Premenstrual Syndrome among Reproductive Age Group Women in Rural Area
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Lakshmi D, John William A Felix, and Jayasree TM
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Premenstrual syndrome ,frequent ,reproductive age group ,Public aspects of medicine ,RA1-1270 - Abstract
Introduction: Premenstrual syndrome (PMS) is a physical, cogni- tive, affective and behavioural symptoms occuring preceding menstruation and disappears after menstruation. It is reported that 50- 80% of women experience PMS. Studies revealed almost 75% of women belonging to reproductive age group experienced symp- toms associated with menstruation. Objective: This study was done to find out distribution of physi- cal symptoms of premenstrual syndrome among study population and also to assess the most frequent physical symptoms of PMS among study population. Methodology: This descriptive cross sectional study was con- ducted in parangipettai town, Cuddalore district among 650 wom- en of reproductive age. Pretested Proforma was used to collect da- ta. The sampling technique used was single stage area wise cluster sampling technique. Results: Out of 650 women, 519 had atleast any one of the follow- ing the physical symptoms. The ranking reveals that general aches and fatigue are the most frequently reported physical symptoms of PMS. The next symptom will be head ache and back ache. Muscle stiffness and painful breasts ranked as the third group of symp- toms followed by other symptoms. Conclusion: General aches, fatigue, headache and backache are the most frequently occurring physical symptoms.
- Published
- 2018
25. Case report: Chronic neutrophilic leukemia associated with monoclonal gammopathies. A case series and review of genetic characteristics and practical management
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Gaël Vermeersch, Michel Delforge, Violaine Havelange, Carlos Graux, Lucienne Michaux, Timothy Devos, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service d'hématologie
- Subjects
Cancer Research ,Science & Technology ,monoclonal gammopathy ,myeloproliferative neoplasm ,2018 UPDATE ,SETBP1 MUTATIONS ,CSF3R ,FREQUENT ,DIAGNOSIS ,myeloid malignancy ,CLONAL EVOLUTION ,DISEASE ,multiple myeloma ,myeloproliferative disorders ,Oncology ,MULTIPLE-MYELOMA ,chronic neutrophilic leukemia ,Life Sciences & Biomedicine ,TYROSINE KINASE MUTATION ,NEOPLASMS - Abstract
Chronic neutrophilic leukemia (CNL) is a rare but potentially aggressive BCR::ABL1 negative myeloproliferative neoplasm, characterized by sustained mature, neutrophilic leukocytosis. The discovery of key driver mutations in the colony-stimulating-factor-3 receptor (CSF3R) gene resulted in the updated World Health Organization (WHO) diagnostic criteria in 2016. A significant number of CNL cases have been associated with plasma cell dyscrasias, predominantly multiple myeloma (MM) and monoclonal gammopathy of unknown significance (MGUS). Compared to pure CNL, mutated CSF3R is infrequently reported in CNL cases associated with monoclonal gammopathies (MG). Until now it remains unclear whether CNL and occurring plasma cell neoplasms are clonally related or CNL is developing secondary to the underlying dyscrasia. Owing to its rarity, currently no standard of care management exists for CNL and MG-associated CNL. In this case series we report the multi-center experience of five MG-associated CNL cases with a median age of diagnosis of 69 years. Three patients (66%) showed predominance of lambda light chain expression. Four (80%) eventually evolved to MM, and one CNL-MGUS patient developed secondary acute myeloid leukemia (AML). Mutated CSF3R was present in the patient who developed AML but was absent in other cases. To assess possible associated genetic aberrations we performed recurrent analysis with next-generation sequencing (NGS). Two patients (40%) deceased with a median time of survival of 8 years after CNL diagnosis. Three (60%) are currently in follow-up with no reoccurring leukocytosis. This case series, followed by a short review, provides a long-term clinical and genetic overview of five CNL cases associated with MG.
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- 2022
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26. Frequent premature atrial complexes as a predictor of atrial fibrillation: Systematic review and meta-analysis.
- Author
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Prasitlumkum, Narut, Rattanawong, Pattara, Limpruttidham, Nath, Kanitsoraphan, Chanavuth, Sirinvaravong, Natee, Suppakitjanusant, Pichatorn, Chongsathidkiet, Pakawat, and Chung, Eugene H.
- Abstract
Background: Frequent premature atrial complexes (PACs) are associated with higher morbidity and mortality. Recent studies suggest that frequent PACs are associated with new onset atrial fibrillation (AF). However, a systematic review and meta-analysis of the literature has not been done. We assessed the association between frequent PACs and new onset AF by a systematic review and a meta-analysis.Methods: We comprehensively searched the databases of MEDLINE and EMBASE from inception to September 2017. Included studies were published cohort (prospective or retrospective) that compared new onset AF among patients with and without frequent PACs documented by Holter monitoring or 12-lead electrocardiogram. Data from each study were combined using the random-effects, generic inverse variance method of DerSimonian and Laird to calculate risk ratios and 95% confidence intervals.Results: Twelve studies from 2009 to 2017 were included in this meta-analysis involving 109,689 subjects (9217frequent and 100,472 non-frequent PACs). Frequent PACs were associated with increased risk of new onset AF (pooled risk ratio = 2.76, 95% confidence interval: 2.05-3.73, p < 0.000, I2 = 90.6%).Conclusion: Frequent PACs are associated with up to three-fold increased risk of new onset AF. Our study suggests that frequent PACs in general population is an independent predictor of new onset AF. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
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27. FREQUENCY AND RISK FACTORS OF FREQUENT EXACERBATIONS OF ASTHMA IN PATIENTS IN A TERTIARY CARE HOSPITAL: A HOSPITAL-BASED COMPARATIVE STUDY.
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Chaudhry, Asma, Toori, Kaleem Ullah, and Saleem, Sumaira
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DISEASE exacerbation , *ASTHMA risk factors , *ASTHMATICS , *TERTIARY care , *EOSINOPHILS , *COMPARATIVE studies - Abstract
Objective: To determine the frequency of recurrent exacerbations in asthma patients and compare the risk factors for frequent and non-frequent exacerbations. Study Design: Cross-sectional study. Place and Duration of Study: KRL Hospital Islamabad from Jun to Dec 2016. Place and Duration of Study: KRL Hospital Islamabad from Jun to Dec 2016. Patients and Methods: Non-probability technique was used to sample two hundred and eighty one patients. Asthma exacerbations were defined by GINA guidelines. Frequent exacerbations were defined as two or more in the previous year. Data regarding demographics and risk factors were collected. Inhaler technique was checked. BMI and blood eosinophil levels were measured. SPSS 22 was used for data analysis. Results: Out of total 281 patients, frequent asthma exacerbations were observed in 143 (50.9%) patients. Female gender (p=0.00) and lower education (p=0.02) led to frequent exacerbations. Patients education about disease or treatment (p=0.03), URTI (p=0.00), allergen exposure (p=0.00), drug history (p=0.04), treatment step-II (p=0.00), medication non-compliance (p=0.00), incorrect inhaler technique (p=0.01), anxiety (p=0.01), previous ICU admission (p=0.02) and blood eosinophilia (p=0.00) were significantly associated with frequent exacerbations. Of these, independent predictors were patient education (p=0.02), URTI (p=0.00), allergen exposure (p=0.00), drug history (p=0.00), treatment step-II (p=0.03), medication non-compliance (p=0.02), anxiety (p=0.01) and eosinophilia (p=0.00). Conclusion: Majority of our patients underwent frequent exacerbations. Risk factors found to be associated with frequent exacerbations were female gender, lower education, patient unawareness, URTI, allergen and drug exposure, treatment step-II, medication non-compliance, anxiety and blood eosinophilia. [ABSTRACT FROM AUTHOR]
- Published
- 2018
28. Association between mood disorders and frequent emergency department use: a cross-sectional study
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Jeffrey J. Perry, Debra Eagles, Yue Chen, Christophe A. Fehlmann, and Marcel Miron-Celis
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medicine.medical_specialty ,Cross-sectional study ,business.industry ,Emergency department ,Mood Disorders ,Frequent ,medicine.disease ,Mood ,Mood disorders ,mental disorders ,Emergency Medicine ,medicine ,Humans ,Cumulative incidence ,Psychiatric ,Bipolar disorder ,medicine.symptom ,Brief Original Research ,business ,Psychiatry ,Emergency Service, Hospital ,Mania ,Depression (differential diagnoses) ,Geriatric - Abstract
Objectives Frequent emergency department (ED) use is a growing problem that is associated with poor patient outcomes and increased health care costs. Our objective was to analyze the association between mood disorders and the incidence of frequent ED use. Methods We used the Canadian Community Health Survey conducted by Statistics Canada, 2015–2016. Mood disorder was defined as depression, bipolar disorder, mania, or dysthymia. Frequent ED use was defined as 4 or more visits in the year preceding the interview. Multivariable log-binomial regression models were used to determine the associations between mood disorders and frequent ED use. Results Among the 99,009 participants, 8.4% had mood disorders, 80.3% were younger than 65, and 2.2% were frequent ED users. Mood disorders were significantly associated with the 1-year cumulative incidence of frequent ED use (RR = 2.5, 95% CI 2.2–2.7), after adjusting for several potential confounders. Conclusions This national survey showed that people with a mood disorder had a three-fold risk of frequent ED use, compared to people without mood disorder. These results can inform the development of policies and targeted interventions aimed at identifying and supporting ED patients with mood disorder.
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- 2021
29. Two Years of Frequent Users in an Urban Emergency Department
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Gerard B Martin, Stephanie A Stokes-Buzzelli, Jennifer M Peltzer-Jones, and Lonni R Schultz
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Frequent ,patients ,recidivism ,Medicine ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Introduction:The purpose of this study was to determine if differences could be detected in the presentation patterns and admission rates among frequent emergency department users (FEDU) of an urban emergency department over a 10-year period.Methods: This was an IRB approved, retrospective review of all patients who presented to the ED 5 or more times for 3 distinct time periods: “year 0” 11/98-10/99, “year 5” 11/03–10/04, and “year 10” 11/08–10/9. FEDU were grouped into those with 5–9, 10–14, 15–19, and ≥ 20 visits per year. Variables analyzed included number of visits, disposition, and insurance status. We performed comparisons using Kolmogorov-Smirnov and chi-square tests. A P < 0.05 was considered significant.Results: We found a a 66% increase in FEDU patients over the decade studied, with a significant increase in both the number of FEDU in each visit frequency category over the 3 time periods (P < 0.0001), as well as the total number of visits by each group of FEDU (P < 0.0001). The proportion of FEDU visits for the 5–9 group resulting in admission increased from 25.9% to 29% from year 0 to year 10 (P < 0.001), but not for the other visit groups. In comparing admission rates between FEDU groups, the admission rate for the 5–9 group was significantly higher than the ≥ 20 group for the year 5 time period (P < 0.001) and the year 10 time period (P < 0.001) and showed a similar trend, but not significant, at year 0 (P = 0.052). The overall hospital admission rate for emergency patients over the same time span remained stable at 22-24%. The overall proportion of uninsured FEDU was stable over the decade studied, while the uninsured rate for the overall ED population for the same time periods increased.Conclusion: The results demonstrate the FEDU population is not a homogeneous group of patients. Increased attention to differences among FEDU groups is necessary in order to plan more effective interventions. [West J Emerg Med. 2013;14(3):243–246.]
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- 2013
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30. Extensive Clonal Branching Shapes the Evolutionary History of High-Risk Pediatric Cancers
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Jenny Karlsson, Diana C.J. Spierings, Floris Foijer, Linda Holmquist Mengelbier, Natalie Andersson, Anders Valind, David Gisselsson, Bjorn Bakker, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL), and Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)
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0301 basic medicine ,Cancer Research ,DNA Copy Number Variations ,DNA Mutational Analysis ,FREQUENT ,Biology ,RELAPSE ,Somatic evolution in cancer ,Clonal Evolution ,03 medical and health sciences ,0302 clinical medicine ,Mutation Rate ,Neoplasms ,Genetic variation ,Exome Sequencing ,MYCN ,medicine ,Biomarkers, Tumor ,Humans ,ALVEOLAR ,Child ,Exome ,RHABDOMYOSARCOMA ,Exome sequencing ,Phylogeny ,FUSION STATUS ,Phylogenetic tree ,Infant ,Wilms' tumor ,medicine.disease ,Prognosis ,Primary tumor ,Survival Analysis ,030104 developmental biology ,Oncology ,Single cell sequencing ,Evolutionary biology ,030220 oncology & carcinogenesis ,Child, Preschool ,NEUROBLASTOMA ,Neoplastic Stem Cells ,Neoplasm Recurrence, Local ,Single-Cell Analysis ,GAIN ,CHILDRENS ONCOLOGY GROUP ,Follow-Up Studies - Abstract
Darwinian evolution of tumor cells remains underexplored in childhood cancer. We here reconstruct the evolutionary histories of 56 pediatric primary tumors, including 24 neuroblastomas, 24 Wilms tumors, and 8 rhabdomyosarcomas. Whole-genome copy-number and whole-exome mutational profiling of multiple regions per tumor were performed, followed by clonal deconvolution to reconstruct a phylogenetic tree for each tumor. Overall, 88% of the tumors exhibited genetic variation among primary tumor regions. This variability typically emerged through collateral phylogenetic branching, leading to spatial variability in the distribution of more than 50% (96/173) of detected diagnostically informative genetic aberrations. Single-cell sequencing of 547 individual cancer cells from eight solid pediatric tumors confirmed branching evolution to be a fundamental underlying principle of genetic variation in all cases. Strikingly, cell-to-cell genetic diversity was almost twice as high in aggressive compared with clinically favorable tumors (median Simpson index of diversity 0.45 vs. 0.88; P = 0.029). Similarly, a comparison of multiregional sampling data from a total of 274 tumor regions showed that new phylogenetic branches emerge at a higher frequency per sample and carry a higher mutational load in high-risk than in low-risk tumors. Timelines based on spatial genetic variation showed that the mutations most influencing relapse risk occur at initiation of clonal expansion in neuroblastoma and rhabdomyosarcoma, whereas in Wilms tumor, they are late events. Thus, from an evolutionary standpoint, some high-risk childhood cancers are born bad, whereas others grow worse over time. Significance: Different pediatric cancers with a high risk of relapse share a common generic pattern of extensively branching evolution of somatic mutations.
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- 2020
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31. Patients with a Higher Number of Periodic Limb Movements Have Higher Nocturnal Blood Pressure
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Klaudia Krzyzaniak, Eemil Partinen, Markku Partinen, Mariusz Sieminski, Clinicum, University of Helsinki, Department of Neurosciences, and HUS Neurocenter
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periodic limb movements ,RESTLESS-LEGS-SYNDROME ,HYPERTENSION ,blood pressure ,polysomnographic ,DOPAMINE-AGONIST TREATMENT ,SLEEP QUALITY ,HEART-RATE ,ASSOCIATION ,FREQUENT ,General Medicine ,COLLABORATION ,PATTERN ,3121 General medicine, internal medicine and other clinical medicine - Abstract
There is growing evidence that periodic limb movements in sleep (PLMS) may lead to increased blood pressure (BP) values during the night. The aim of this study was to assess if patients with disordered sleep and an increased number of PLMS have higher BP values at night. We analyzed 100 polysomnographic (PSG) recordings of patients with disordered sleep, with the exclusion of sleep-related breathing disorders. Patients also registered beat-to-beat blood pressure during PSG. We compared the BP of patients with an increased number of PLMS (more than 5 PLMS per hour of sleep) during the night (examined group, n = 50) to the BP of patients with a PLMS number within the normal range (up to 5 PLMS per hour of sleep) (control group, n = 50). Patients from the examined group had significantly higher values of systolic BP during the night (119.7 mmHg vs. 113.3 mmHg, p = 0.04), sleep (119.0 mmHg vs. 113.3 mmHg, p = 0.04), and wake (122.5 mmHg vs. 117.2 mmHg, p = 0.04) periods and of diastolic BP during the night (75.5 mmHg vs. 70.6 mmHg, p = 0.04) and wake (77.6 mmHg vs. 71.5 mmHg, p = 0.01) periods. Our results suggest a relationship between the number of PLMS during the night and the values of nocturnal blood pressure. It is possible that their treatment could lower nocturnal BP in patients with sleep disorders, therefore improving their vascular risk profile.
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- 2022
32. Health-Related Quality of Life and Psychological Distress in Patients With Hypermobility Type Ehlers-Danlos Syndrome
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Tage Orenius, Hannu Kautiainen, Marja Louhi, Liisa Montin, Antonio Bulbena, Karl-August Lindgren, Department of General Practice and Primary Health Care, Clinicum, and Helsinki University Hospital Area
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RAND-36 ,General Arts and Humanities ,ANXIETY DISORDERS ,General Social Sciences ,hypermobile type ,ASSOCIATION ,FREQUENT ,DEPRESSION ,humanities ,STATE ,health-related quality of life ,TRAIT ,PHYSICAL-ACTIVITY ,3121 General medicine, internal medicine and other clinical medicine ,Ehlers-Danlos Syndrome ,MUSCULOSKELETAL PAIN ,FEAR-AVOIDANCE ,anxiety subtypes - Abstract
Patients with Ehlers-Danlos Syndrome, hypermobile type (hEDS) often report a decrease of health-related quality of life (HRQoL), symptoms of anxiety and depression, and show a prevalent incidence of psychiatric disorders. Still, there seems to be a lack of a more thorough analysis addressing the relations between these entities. We studied the HRQoL and its relations with depressive symptoms and subgroups of anxiety in a group of patients with hEDS ( n = 81) compared to a comparison group ( n = 90) of healthy controls (HC). HRQoL was assessed with the RAND 36-item health survey, depressive symptoms were measured with the 21-item Beck Depression Inventory (BDI-II) and State/trait anxiety inventory (STAI) was used to estimate levels of state and trait anxiety. The hEDS group showed significantly lower scores on total HRQoL, on all subscales as well on calculated subgroups of physical and mental HRQoL than the HC group. Depression, state, and trait anxiety scores were significantly higher in hEDS group than in the HC group. However, both state and trait anxiety showed a lower degree of negative associations with social functioning in the hEDS group when compared to the HC group. Patients with hEDS present with a lower HRQoL and greater psychological distress than healthy individuals. These factors play a significant role in the patients’ overall functional capacity and should be noticed when examining and treating patients with hEDS.
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- 2022
33. Lucid dreaming incidence: A quality effects meta-analysis of 50 years of research.
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Saunders, David T., Roe, Chris A., Smith, Graham, and Clegg, Helen
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LUCID dreams , *SENSITIVITY (Personality trait) , *SUBCONSCIOUSNESS , *MENTAL status examination , *COGNITION - Abstract
We report a quality effects meta-analysis on studies from the period 1966–2016 measuring either (a) lucid dreaming prevalence (one or more lucid dreams in a lifetime); (b) frequent lucid dreaming (one or more lucid dreams in a month) or both. A quality effects meta-analysis allows for the minimisation of the influence of study methodological quality on overall model estimates. Following sensitivity analysis, a heterogeneous lucid dreaming prevalence data set of 34 studies yielded a mean estimate of 55%, 95% C. I. [49%, 62%] for which moderator analysis showed no systematic bias for suspected sources of variability. A heterogeneous lucid dreaming frequency data set of 25 studies yielded a mean estimate of 23%, 95% C. I. [20%, 25%], moderator analysis revealed no suspected sources of variability. These findings are consistent with earlier estimates of lucid dreaming prevalence and frequent lucid dreaming in the population but are based on more robust evidence. [ABSTRACT FROM AUTHOR]
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- 2016
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34. Prognostic role of SCAMP family in acute myeloid leukemia
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Ling Liu, Lin Fu, Cong Deng, Liang Quan, Ying Pang, Wenhui Huang, Jinghong Chen, Jinlong Shi, Chaozeng Si, Yang Jiao, Longzhen Cui, Xu Ye, Yan Liu, Tiansheng Zeng, Yifeng Dai, Zhiheng Cheng, Tingting Qian, and Faculteit Medische Wetenschappen/UMCG
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Adult ,Male ,EXPRESSION ,0301 basic medicine ,FLT3-ITD ,Myeloid ,medicine.medical_treatment ,Vesicular Transport Proteins ,NPM1 MUTATION ,Antineoplastic Agents ,FREQUENT ,DEFINE ,Hematopoietic stem cell transplantation ,ASXL1 ,Gene mutation ,030226 pharmacology & pharmacy ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,hemic and lymphatic diseases ,Databases, Genetic ,MYELODYSPLASTIC SYNDROMES ,Genetics ,medicine ,Humans ,Progenitor cell ,Aged ,Aged, 80 and over ,Pharmacology ,Chemotherapy ,business.industry ,Myeloid leukemia ,TP53 GENE ,Middle Aged ,Prognosis ,Leukemia, Myeloid, Acute ,Haematopoiesis ,030104 developmental biology ,medicine.anatomical_structure ,Cancer research ,Molecular Medicine ,Female ,Bone marrow ,business ,CARRIER MEMBRANE-PROTEINS - Abstract
Acute myeloid leukemia (AML) is a malignant disease of myeloid hematopoietic stem or progenitor cells characterized by abnormal proliferation of primary and immature myeloid cells in bone marrow and peripheral blood. Gene mutation and expression profiles can be used as prognosis predictors for different prognostic subgroups. Secretory carrier-associated membrane proteins (SCAMPs) are a multigenic family with five members and act as cell surface vectors in the post-Golgi recycling pathways in mammals. Nevertheless, the prognostic and clinical influence of SCAMP family has hardly ever been illustrated in AML. In our study, expression patterns of SCAMP family (SCAMP1-5) were analyzed in 155 AML patients which were extracted from the Cancer Genome Atlas database. In chemotherapy, only subgroup, higher SCAMP1 level was significantly associated with longer EFS and OS (all P = 0.002), and SCAMP1 was confirmed to be an independent favorable factor in un-transplanted patients by Multivariate analysis (all P
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- 2020
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35. Metástasis óseas estudiadas con tomografía por emisión de positrones en combinación con tomografía simple: perfil epidemiológico en relación con el tumor primario.
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LI, Vivas-Mosquera, J, Soto-Andonaegui, and SA, Criales-Vera
- Abstract
OBJECTIVE: obtain an epidemiological profile of patients with neoplasms metastatic to bone, documented by positron emission tomography combined with simple tomography, in relation to the primary tumor. INTRODUCTION: based on tomographic studies of patients with cancer metastatic to bone, we conducted a statistical analysis to obtain an epidemiological profile of bone metastases in relation to the primary tumor, frequency of compromise in each particular bone, and the presence of concomitant spread to other organs. MATERIALS AND METHODS: a descriptive study from a database of 250 patients with extraosseous primary neoplasm (132 men and 118 women), who were monitored or diagnosed by positron emission tomography combined with simple tomography. Patients with metastasis were selected to determine the epidemiological profile of bone metastases in relation to the primary tumor, compromise by bone, and the presence of metastatic compromise to other organs. RESULTS: metastasis to bone was found in 12.8% of the cases, occurring with greater relative frequency in hepatic carcinoma (2 of 4 cases), followed by prostate (33.3%), lung (25%), lymphoma (15%), breast (14.9%), pancreas (14.2%), esophagus (14.2%), and bladder (10%). Excluding cases of prostate or breast carcinoma, bone metastases were found in 8.4% of women and 10.1% of men with average ages of 60.5 and 74.1 years, respectively. The bone most commonly affected was the ilium (31%) followed by the vertebrae (27%). Concomitant extraosseous compromise was 76% to lymph nodes and 62% to other organs. DISCUSSION: The lower frequency of bone metastases (12.8% vs. 30- 85%) found may be due to the different clinical indications of positron emission tomography combined with simple tomography and bone gammagram; the latter is usually used in cases of direct suspicion of bone metastasis, and not the former. CONCLUSIONS: we found a frequency of 12.8% of bone metastasis; usually bone compromise was greater in males (except cases of liver cancer and lymphoma). In more than half of the cases of tumoral disease with extension to bone there was also compromise of other organs. [ABSTRACT FROM AUTHOR]
- Published
- 2016
36. Graph Classification based on Top near optimal Co-occurrence Graph patterns of size-k.
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Muhamad, Maniraguha, Assouma, Nyirabahizi, Ntawumenyikizaba, A., Lee, YK, and Lee, SY
- Abstract
In the Graph classification context, frequent graph patterns are more used by many researchers as graphs classification features because its significant outcome result in graph classification such as prediction of proteins and molecules, graph data analysis and computation program flows. However, frequent pattern mined becomes non-trivial since the number of patterns is exponential. For this reason graph pattern mining has shifted from finding all frequent subgraphs to obtaining a small subset of frequent subgraphs that are representative, discriminative or significant. The process of finding a subset among all frequent subgraphs is NP-hard and estimation heuristic algorithms used doesn't give optimal solution of subset selected. In this paper we present an approach “Graph Classification based on Top near optimal Co-occurrence Graph patterns of size-k (TCG)”. The approach exploits the submodular property of information gain and special greedily select top co-occurrence subgraphs of size k among frequent subgraphs. Graph classification built on mined co-occurrence subgraphs show the quality of our approach and improvement on accuracy. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
37. Low-Rate Overuse Flow Tracer (LOFT): An Efficient and Scalable Algorithm for Detecting Overuse Flows
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Nele Mentens, Arish Sateesan, Benjamin Rothenberger, Che-Yu Wu, Yu-Hsi Chiang, Jo Vliegen, Simon Scherrer, Adrian Perrig, Hsu-Chun Hsiao, and Daniele Enrico Asoni
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network monitoring ,FOS: Computer and information sciences ,Technology ,Computer Science - Cryptography and Security ,Computer science ,Packet processing ,Real-time computing ,Quality of Service ,FREQUENT ,02 engineering and technology ,flow monitoring ,sketching ,Computer Science - Networking and Internet Architecture ,Computer Science, Theory & Methods ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Bandwidth (computing) ,DIRECTIONS ,Computer Science, Hardware & Architecture ,Field-programmable gate array ,Networking and Internet Architecture (cs.NI) ,Science & Technology ,Computer Science, Information Systems ,Quality of service ,Probabilistic logic ,020206 networking & telecommunications ,Network monitoring ,Computer Science ,Anomaly detection ,Timeout ,Cryptography and Security (cs.CR) - Abstract
Current probabilistic flow-size monitoring can only detect heavy hitters (e.g., flows utilizing 10 times their permitted bandwidth), but cannot detect smaller overuse (e.g., flows utilizing 50-100 % more than their permitted bandwidth). Thus, these systems lack accuracy in the challenging environment of high-throughput packet processing, where fast-memory resources are scarce. Nevertheless, many applications rely on accurate flow-size estimation, e.g., for network monitoring, anomaly detection and Quality of Service. We design, analyze, implement, and evaluate LOFT, a new approach for efficiently detecting overuse flows that achieves dramatically better properties than prior work. LOFT can detect 1.50x overuse flows in one second, whereas prior approaches can only reliably detect flows that overuse their allocation by at least 3x. We demonstrate LOFT's suitability for high-speed packet processing with implementations in the DPDK framework and on an FPGA.
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- 2021
38. Efficient mining frequent itemsets algorithms.
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Mohamed, Marghny and Darwieesh, Mohammed
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Efficient algorithms for mining frequent itemsets are crucial for mining association rules as well as for many other data mining tasks. It is well known that countTable is one of the most important facility to employ subsets property for compressing the transaction database to new lower representation of occurrences items. One of the biggest problem in this technique is the cost of candidate generation and test processing which are the two most important steps to find association rules. In this paper, we have developed this method to avoid the costly candidate-generation-and-test processing completely. Moreover, the proposed methods also compress crucial information about all itemsets, maximal length frequent itemsets, minimal length frequent itemsets, avoid expensive, and repeated database scans. The proposed named CountTableFI and BinaryCountTableF are presented, the algorithm has significant difference from the Apriori and all other algorithms extended from Apriori. The idea behind this algorithm is in the representation of the transactions, where, we represent all transactions in binary number and decimal number, so it is simple and fast to use subset and identical set properties. A comprehensive performance study shows that our techniques are efficient and scalable comparing with other methods. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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39. Phenotypic and genotypic features of a large kindred with a germline AIP variant
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Jakob Dal, Søren Vang, Marianne Andersen, Ulla Feldt-Rasmussen, Marianne Klose, Márta Korbonits, Jens Otto Lunde Jørgensen, and Eigil Husted Nielsen
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Adenoma ,PITUITARY-ADENOMA PREDISPOSITION ,Candidate gene ,medicine.medical_specialty ,Heterozygote ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Context (language use) ,pituitary adenoma ,FREQUENT ,PHOSPHODIESTERASE 11A PDE11A ,Biology ,Germline ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,Genotype ,Acromegaly ,medicine ,SEQUENCE VARIANTS ,Humans ,Pituitary Neoplasms ,COHORT ,gigantism ,Exome sequencing ,Germ-Line Mutation ,AIP gene variant ,Genetics ,MUTATIONS ,Infant, Newborn ,medicine.disease ,Penetrance ,Gigantism ,PREVALENCE ,GH ,IGF-I ,Germ Cells ,Phenotype ,030220 oncology & carcinogenesis ,INTERACTING-PROTEIN GENE ,Mutation ,YOUNG-PATIENTS ,acromegaly ,Growth Hormone-Secreting Pituitary Adenoma ,familial acromegaly - Abstract
CONTEXT: Acromegaly is usually a sporadic disease, but familial cases occur. Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are associated with familial pituitary adenoma predisposition. However, the pathogenicity of some AIP variants remains unclear and additional unknown genes may be involved.OBJECTIVE: To explore the phenotype and genotype of a large kindred carrying the p.R304Q AIP variant.METHODS: The family comprised 52 family members at risk of carrying the p.R304Q AIP variant including a case with gigantism and one with acromegaly and several family members with acromegalic features. Nine family members (three trios) underwent exome sequencing to identify putative pathogenic variants.RESULTS: We identified 31 p.R304Q carriers, and based on two cases with somatotropinomas, the disease penetrance was 6%. We observed physical signs of acromegaly in several family members, which were independent of AIP status. Serum insulin-like growth factor-I (IGF-I) levels in all family members were above the mean for age and sex (IGF-I SDS: +0.6 [CI95% +0.4-0.9], P < .01). Exome analysis identified two candidate genes: PDE11A, known to be associated with the development of adrenal tumours, and ALG14. Ten asymptomatic p.R304Q family members (age >50 years) were screened for the PDE11A and ALG14 variant; both variants were present in five of ten persons.CONCLUSIONS: This large family adds new information on the p.R304Q AIP variant, and data suggest two new candidate genes could be associated with growth hormone excess.
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- 2020
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40. Survival of a male patient harboring CASK Arg27Ter mutation to adolescence
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Deepa S. Rajan, Paras A. Patel, Sarika Srivastava, Konark Mukherjee, Leslie E. W. LaConte, and Fralin Biomedical Research Institute
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Male ,0301 basic medicine ,cerebellar hypoplasia ,Microcephaly ,Pathology ,medicine.medical_specialty ,Palliative care ,lcsh:QH426-470 ,Adolescent ,Pontocerebellar hypoplasia ,FREQUENT ,030105 genetics & heredity ,Clinical Reports ,CASK ,03 medical and health sciences ,Loss of Function Mutation ,Intellectual Disability ,Genetics ,medicine ,Humans ,Abnormalities, Multiple ,microcephaly ,Molecular Biology ,Cerebellar hypoplasia ,Genetics (clinical) ,Genetics & Heredity ,Cerebral atrophy ,0604 Genetics ,Optic nerve hypoplasia ,Clinical Report ,Epilepsy ,0304 Medicinal and Biomolecular Chemistry ,business.industry ,1103 Clinical Sciences ,Genetic Diseases, X-Linked ,electroencephalogram ,medicine.disease ,Hypoplasia ,lcsh:Genetics ,epileptic encephalopathy ,030104 developmental biology ,HYPOPLASIA ,business ,Life Sciences & Biomedicine ,Guanylate Kinases - Abstract
Background CASK is an X‐linked gene in mammals and its deletion in males is incompatible with life. CASK heterozygous mutations in female patients associate with intellectual disability, microcephaly, pontocerebellar hypoplasia, and optic nerve hypoplasia, whereas CASK hemizygous mutations in males manifest as early infantile epileptic encephalopathy with a grim prognosis. Here, we report a rare case of survival of a male patient harboring a CASK null mutation to adolescent age. Methods Trio whole exome sequencing analysis was performed from blood genomic DNA. Magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and electroencephalogram (EEG) analyses were performed to determine anomalies in brain development, metabolite concentrations, and electrical activity, respectively. Results Trio‐WES analysis identified a de novo c.79C>T (p.Arginine27Ter) mutation in CASK causing a premature translation termination at the very N‐terminus of the protein. The 17‐years, and 11‐month‐old male patient displayed profound intellectual disability, microcephaly, dysmorphism, ponto‐cerebellar hypoplasia, and intractable epilepsy. His systemic symptoms included overall reduced somatic growth, dysautonomia, ventilator and G tube dependence, and severe osteopenia. Brain MRI revealed a severe cerebellar and brain stem hypoplasia with progressive cerebral atrophy. EEG spectral analysis revealed a global functional defect with generalized background slowing and delta waves dominating even in the awake state. Conclusion This case study is the first to report survival of a male patient carrying a CASK loss‐of‐function mutation to adolescence and highlights that improved palliative care could extend survival. Moreover, the genomic position encoding Arg27 in CASK may possess an increased susceptibility to mutations., Loss‐of‐function mutations in the X‐linked gene CASK are frequently lethal in males or produce epileptic encephalopathy with severe neurodevastation. Here, we first report a male patient with CASK R27* null mutation having a nearly complete loss of CASK function and surviving to late adolescence.
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- 2020
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41. Exacerbation Patterns in Adults with Asthma in England. A Population-based Study
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Thomas Palmer, Chloe I Bloom, Paul Cullinan, Jennifer K Quint, and Johanna Feary
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Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Exacerbation ,Respiratory System ,FREQUENT ,macromolecular substances ,Critical Care and Intensive Care Medicine ,Body Mass Index ,Young Adult ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Critical Care Medicine ,exacerbations ,Recurrence ,Risk Factors ,Sex factors ,General & Internal Medicine ,Epidemiology ,medicine ,EPIDEMIOLOGY ,Humans ,030212 general & internal medicine ,frequent exacerbator ,Young adult ,11 Medical and Health Sciences ,Asthma ,Science & Technology ,business.industry ,Age Factors ,Case-control study ,asthma ,Middle Aged ,medicine.disease ,Population based study ,England ,Socioeconomic Factors ,030228 respiratory system ,Case-Control Studies ,Disease Progression ,Female ,frequent-exacerbator ,business ,Life Sciences & Biomedicine ,Body mass index - Abstract
Rationale Asthma is heterogeneous and knowledge on exacerbation patterns is lacking. Previous studies have had a relatively short follow-up or focused on severe disease. Objectives Describe exacerbation patterns over a prolonged follow-up in a population including patients of all disease severity. Methods We used electronic healthcare records to identify asthma patients aged 18-55 years and their exacerbations, 2007-2015. A cohort with ≥7-years of data was used to describe exacerbation patterns by asthma severity defined by medication use. Effect estimates for risk factors were calculated for sporadic (single year of exacerbations) and recurrent (>1 year) exacerbation patterns, using logistic regression. In a nested case-control design, the association between a history of exacerbations, spanning 5-years, and a future exacerbation was examined. Measurements and Main Results 51,462 patients were eligible for the 7-year cohort; 64% had no exacerbations. Of those who exacerbated, 51% did so only once; exacerbation frequency increased with disease severity. Only 370 patients (0.7%) were characterised by a frequent-exacerbator phenotype (yearly exacerbations), of whom 58% had mild/moderate asthma. Exacerbation risk factors were not uniquely associated with a particular exacerbation pattern. A past exacerbation increased the risk of a future exacerbation more than all other factors, although this effect dissipated over 5-years. Conclusions During 7-years of follow-up, exacerbations occur in around one-third of patients. Of those who exacerbate, half do not do so again; the timing of future exacerbations is largely unpredictable. Just 2% exhibit a frequent-exacerbator phenotype. Past exacerbation patterns are the most informative risk factor for predicting future exacerbations.
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- 2019
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42. Long-term sickness absence in a working population: development and validation of a risk prediction model in a large Dutch prospective cohort
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Angelique de Rijk, Ramon P G Ottenheijm, Geert-Jan Dinant, Martijn W. Heymans, Lennart R.A. van der Burg, Sander M. J. van Kuijk, Marieke M. ter Wee, Goedele A. Geuskens, Annelies Boonen, Interne Geneeskunde, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, MUMC+: KIO Kemta (9), Epidemiologie, RS: CAPHRI - R2 - Creating Value-Based Health Care, Sociale Geneeskunde, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Family Medicine, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiology and Data Science, APH - Personalized Medicine, and APH - Methodology
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Male ,Gerontology ,Health Status ,Psychological intervention ,Logistic regression ,0302 clinical medicine ,Risk Factors ,Discrimination ,Medicine ,Working persons ,Longitudinal Studies ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Netherlands ,lcsh:Public aspects of medicine ,WORKERS ,Middle Aged ,030210 environmental & occupational health ,External validation ,Cohort ,Calibration ,Female ,EMPLOYEES ,HEALTH ,Sick Leave ,Research Article ,Employment ,Matching (statistics) ,Long-term sickness absence ,FREQUENT ,Development ,Risk Assessment ,Life Change Events ,03 medical and health sciences ,Prediction model ,Humans ,Generalizability theory ,Models, Statistical ,business.industry ,Prevention ,DISABILITY ,Public Health, Environmental and Occupational Health ,lcsh:RA1-1270 ,Missing data ,INDIVIDUALS ,Socioeconomic Factors ,LOST PRODUCTIVITY ,Biostatistics ,business ,Prediction - Abstract
Background Societal expenditures on work-disability benefits is high in most Western countries. As a precursor of long-term work restrictions, long-term sickness absence (LTSA) is under continuous attention of policy makers. Different healthcare professionals can play a role in identification of persons at risk of LTSA but are not well trained. A risk prediction model can support risk stratification to initiate preventative interventions. Unfortunately, current models lack generalizability or do not include a comprehensive set of potential predictors for LTSA. This study is set out to develop and validate a multivariable risk prediction model for LTSA in the coming year in a working population aged 45–64 years. Methods Data from 11,221 working persons included in the prospective Study on Transitions in Employment, Ability and Motivation (STREAM) conducted in the Netherlands were used to develop a multivariable risk prediction model for LTSA lasting ≥28 accumulated working days in the coming year. Missing data were imputed using multiple imputation. A full statistical model including 27 pre-selected predictors was reduced to a practical model using backward stepwise elimination in a logistic regression analysis across all imputed datasets. Predictive performance of the final model was evaluated using the Area Under the Curve (AUC), calibration plots and the Hosmer-Lemeshow (H&L) test. External validation was performed in a second cohort of 5604 newly recruited working persons. Results Eleven variables in the final model predicted LTSA: older age, female gender, lower level of education, poor self-rated physical health, low weekly physical activity, high self-rated physical job load, knowledge and skills not matching the job, high number of major life events in the previous year, poor self-rated work ability, high number of sickness absence days in the previous year and being self-employed. The model showed good discrimination (AUC 0.76 (interquartile range 0.75–0.76)) and good calibration in the external validation cohort (H&L test: p = 0.41). Conclusions This multivariable risk prediction model distinguishes well between older workers with high- and low-risk for LTSA in the coming year. Being easy to administer, it can support healthcare professionals in determining which persons should be targeted for tailored preventative interventions.
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- 2020
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43. Frequent Pattern Mining on Time and Location Aware Air Quality Data
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Durga Toshniwal and Apeksha Aggarwal
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010504 meteorology & atmospheric sciences ,General Computer Science ,Computer science ,Big data ,Sample (statistics) ,02 engineering and technology ,computer.software_genre ,01 natural sciences ,0202 electrical engineering, electronic engineering, information engineering ,General Materials Science ,0105 earth and related environmental sciences ,frequent ,business.industry ,spatio-temporal ,General Engineering ,data mining ,Data structure ,Task (computing) ,itemset ,Air quality ,Benchmark (computing) ,020201 artificial intelligence & image processing ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,Data mining ,business ,lcsh:TK1-9971 ,Database transaction ,computer ,Transaction data - Abstract
With the advent of big data era, enormous volumes of data are generated every second. Varied data processing algorithms and architectures have been proposed in the past to achieve better execution of data mining algorithms. One such algorithm is extracting most frequently occurring patterns from the transactional database. Dependency of transactions on time and location further makes frequent itemset mining task more complex. The present work targets to identify and extract the frequent patterns from such time and location-aware transactional data. Primarily, the spatio-temporal dependency of air quality data is leveraged to find out frequently co-occurring pollutants over several locations of Delhi, the capital city of India. Varied approaches have been proposed in the past to extract frequent patterns efficiently, but this work suggests a generalized approach that can be applied to any numeric spatio-temporal transactional data, including air quality data. Furthermore, a comprehensive description of the algorithm along with a sample running example on air quality dataset is shown in this work. A detailed experimental evaluation is carried out on the synthetically generated datasets, benchmark datasets, and real world datasets. Furthermore, a comparison with spatio-temporal apriori as well as the other state-of-the-art non-apriori-based algorithms is shown. Results suggest that the proposed algorithm outperformed the existing approaches in terms of execution time of algorithm and memory resources.
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- 2019
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44. STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK− ALCL
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Emma I. Andersson, Sonja Lagström, Satu Mustjoki, Till Braun, Marco Herling, Panu E. Kovanen, Pekka Ellonen, Susanna Mannisto, Oscar Brück, Leena Saikko, Sirpa Leppä, Faculty of Medicine, HUSLAB, Hematologian yksikkö, University of Helsinki, Helsinki University Hospital Area, TRIMM - Translational Immunology Research Program, Department of Clinical Chemistry and Hematology, Research Programs Unit, HUS Comprehensive Cancer Center, Department of Oncology, Medicum, Institute for Molecular Medicine Finland, and Department of Pathology
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0301 basic medicine ,Cancer Research ,CD30 ,3122 Cancers ,lymphoma ,FREQUENT ,Gene mutation ,DIAGNOSIS ,medicine.disease_cause ,lcsh:RC254-282 ,Article ,STAT3 ,03 medical and health sciences ,0302 clinical medicine ,hemic and lymphatic diseases ,PERIPHERAL T-CELL ,KINASE ,medicine ,SIGNATURES ,Mutation ,LANDSCAPE ,biology ,TRANSPLANTATION ,Chemistry ,T-cells ,JAK-STAT signaling pathway ,RHOA ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Phenotype ,Lymphoma ,Transplantation ,030104 developmental biology ,GEMCITABINE ,Oncology ,030220 oncology & carcinogenesis ,NGS ,Cancer research ,biology.protein - Abstract
Peripheral T-cell lymphomas (PTCL) are a heterogeneous, and often aggressive group of non-Hodgkin lymphomas. Recent advances in the molecular and genetic characterization of PTCLs have helped to delineate differences and similarities between the various subtypes, and the JAK/STAT pathway has been found to play an important oncogenic role. Here, we aimed to characterize the JAK/STAT pathway in PTCL subtypes and investigate whether the activation of the pathway correlates with the frequency of STAT gene mutations. Patient samples from AITL (n = 30), ALCL (n = 21) and PTCL-NOS (n = 12) cases were sequenced for STAT3, STAT5B, JAK1, JAK3, and RHOA mutations using amplicon sequencing and stained immunohistochemically for pSTAT3, pMAPK, and pAKT. We discovered STAT3 mutations in 13% of AITL, 13% of ALK+ ALCL, 38% of ALK&minus, ALCL and 17% of PTCL-NOS cases. However, no STAT5B mutations were found and JAK mutations were only present in ALK- ALCL (15%). Concurrent mutations were found in all subgroups except ALK+ ALCL where STAT3 mutations were always seen alone. High pY-STAT3 expression was observed especially in AITL and ALCL samples. When studying JAK-STAT pathway mutations, pY-STAT3 expression was highest in PTCLs harboring either JAK1 or STAT3 mutations and CD30+ phenotype representing primarily ALK&minus, ALCLs. Further investigation is needed to elucidate the molecular mechanisms of JAK-STAT pathway activation in PTCL.
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- 2020
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45. Survival of a male patient harboring CASK Arg27Ter mutation to adolescence
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Mukherjee, Konark, Patel, Paras A., Rajan, Deepa S., LaConte, Leslie E. W., Srivastava, Sarika, Mukherjee, Konark, Patel, Paras A., Rajan, Deepa S., LaConte, Leslie E. W., and Srivastava, Sarika
- Abstract
Background: CASK is an X-linked gene in mammals and its deletion in males is incompatible with life. CASK heterozygous mutations in female patients associate with intellectual disability, microcephaly, pontocerebellar hypoplasia, and optic nerve hypoplasia, whereas CASK hemizygous mutations in males manifest as early infantile epileptic encephalopathy with a grim prognosis. Here, we report a rare case of survival of a male patient harboring a CASK null mutation to adolescent age. Methods: Trio whole exome sequencing analysis was performed from blood genomic DNA. Magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and electroencephalogram (EEG) analyses were performed to determine anomalies in brain development, metabolite concentrations, and electrical activity, respectively. Results: Trio-WES analysis identified a de novo c.79C>T (p.Arginine27Ter) mutation in CASK causing a premature translation termination at the very N-terminus of the protein. The 17-years, and 11-month-old male patient displayed profound intellectual disability, microcephaly, dysmorphism, ponto-cerebellar hypoplasia, and intractable epilepsy. His systemic symptoms included overall reduced somatic growth, dysautonomia, ventilator and G tube dependence, and severe osteopenia. Brain MRI revealed a severe cerebellar and brain stem hypoplasia with progressive cerebral atrophy. EEG spectral analysis revealed a global functional defect with generalized background slowing and delta waves dominating even in the awake state. Conclusion: This case study is the first to report survival of a male patient carrying a CASK loss-of-function mutation to adolescence and highlights that improved palliative care could extend survival. Moreover, the genomic position encoding Arg27 in CASK may possess an increased susceptibility to mutations.
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- 2020
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46. Survival of a male patient harboring CASK Arg27Ter mutation to adolescence
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Fralin Biomedical Research Institute, Mukherjee, Konark, Patel, Paras A., Rajan, Deepa S., LaConte, Leslie E. W., Srivastava, Sarika, Fralin Biomedical Research Institute, Mukherjee, Konark, Patel, Paras A., Rajan, Deepa S., LaConte, Leslie E. W., and Srivastava, Sarika
- Abstract
Background: CASK is an X-linked gene in mammals and its deletion in males is incompatible with life. CASK heterozygous mutations in female patients associate with intellectual disability, microcephaly, pontocerebellar hypoplasia, and optic nerve hypoplasia, whereas CASK hemizygous mutations in males manifest as early infantile epileptic encephalopathy with a grim prognosis. Here, we report a rare case of survival of a male patient harboring a CASK null mutation to adolescent age. Methods: Trio whole exome sequencing analysis was performed from blood genomic DNA. Magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and electroencephalogram (EEG) analyses were performed to determine anomalies in brain development, metabolite concentrations, and electrical activity, respectively. Results: Trio-WES analysis identified a de novo c.79C>T (p.Arginine27Ter) mutation in CASK causing a premature translation termination at the very N-terminus of the protein. The 17-years, and 11-month-old male patient displayed profound intellectual disability, microcephaly, dysmorphism, ponto-cerebellar hypoplasia, and intractable epilepsy. His systemic symptoms included overall reduced somatic growth, dysautonomia, ventilator and G tube dependence, and severe osteopenia. Brain MRI revealed a severe cerebellar and brain stem hypoplasia with progressive cerebral atrophy. EEG spectral analysis revealed a global functional defect with generalized background slowing and delta waves dominating even in the awake state. Conclusion: This case study is the first to report survival of a male patient carrying a CASK loss-of-function mutation to adolescence and highlights that improved palliative care could extend survival. Moreover, the genomic position encoding Arg27 in CASK may possess an increased susceptibility to mutations.
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- 2020
47. Timber harvest and frequent prescribed burning interact to affect the demography of Eucalypt species
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Watson, Georgia M, French, Kris, Collins, L, Watson, Georgia M, French, Kris, and Collins, L
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Ecosystem management can negatively affect the demography of plant communities through the introduction of novel disturbance regimes. Prescribed burning and timber harvesting are two common and widely applied management strategies across forest ecosystems. Despite this, little is known about the long-term effects that these interacting disturbances have on forest demography. This study examined the effect of timber harvesting and frequent prescribed burning on the mortality, growth and regeneration of trees in a temperate eucalypt forest of south-eastern Australia. The study took place at a long-term experimental site, where experimental coupes were subjected to a one-off selective harvesting treatment (harvested, not harvested), followed by regimes of experimental burning (no fire, ~4 year burn intervals or ~2 year burn intervals) over a 22 year period. Tree communities were surveyed at permanent monitoring sites prior to the application of experimental treatments (1985 – 1989), and resurveyed post treatment (2016) to assess mortality, growth rates and ingrowth of trees >10 cm diameter at breast height. Harvesting directly removed ~40% of trees and indirectly increased the mortality of retained trees through damage (e.g. crown and bole breakage) caused during the harvesting operation. The likelihood of harvesting damage was greater for small trees and increased with harvesting intensity (i.e. the amount of timber removed). Frequent burning increased the likelihood of tree mortality on harvested sites, with large, old trees being particularly vulnerable. Growth rate and ingrowth of trees was elevated at harvested sites, increasing almost linearly with harvesting intensity, which suggests that competitive release had occurred. Fire frequency had no effect on growth rates or ingrowth of trees. This study highlights that frequent prescribed burning and selective timber harvesting can have additive effects on the loss of large trees, reducing the availability of these k
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- 2020
48. Impact of frequent hemodialysis on anemia management: results from the Frequent Hemodialysis Network (FHN) Trials.
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Ornt, Daniel B., Larive, Brett, Rastogi, Anjay, Rashid, Mohamad, Daugirdas, John T., Hernandez, Ann, Tamura, Manjula Kurella, Suri, Rita S., Levin, Nathan W., and Kliger, Alan S.
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ANEMIA treatment , *HEMODIALYSIS , *HEALTH outcome assessment , *HEMOGLOBINS , *ERYTHROPOIETIN , *DRUG dosage , *CLINICAL trials - Abstract
Background The extent to which anemia management is facilitated by more frequent hemodialysis (HD) is controversial. We hypothesized as a preselected outcome that patients receiving HD six times (6×) compared with three times (3×) per week would require lower doses of erythropoietin-stimulating agents (ESA) and/or achieve higher blood hemoglobin (Hb) concentrations. Methods Subjects enrolled in the Frequent Hemodialysis Network (FHN) daily and nocturnal trials were studied. As the primary outcome for anemia, the dose of ESAs was recorded at 4-month intervals and the monthly dose of intravenous iron (IV Fe) was reported. Serum iron, transferrin saturation and ferritin were measured at baseline and then at 4-month intervals, whereas Hb concentration was measured monthly. Results There was no significant treatment effect in the 6× versus 3× treatment groups on logESA dose or the ratio of log of ESA dose to Hb concentration in either trial. In the daily trial, Hb concentrations increased significantly in the 6× versus 3× group, at Month 12 compared with baseline (0.3 g/dL; 95% CI: 0.05–0.58, P < 0.021), but both groups had Hb concentrations in the usual target range. In the daily trial, the weekly logESA dose and the logESA dose to Hb concentration ratio tended to decline more in the 6× versus 3× group. This trend was not observed in the nocturnal trial. IV Fe doses were significantly lower in the 6× compared with the 3× group by Month 12 in the nocturnal trial, but not different in the daily trial. Conclusions In the FHN Daily and Nocturnal Trials, more frequent HD did not have a significant or clinically important effect on anemia management. [ABSTRACT FROM AUTHOR]
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- 2013
49. SCUCCINTĂ ANALIĂ ASUPRA PROBLEMELOR PE CARE TREBUIE SĂ LE CLARIFICE ANCHETA PENALĂ PE PARCURSUL INVESTIGĂRII FAPTELOR DE FURT.
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RUIU, Marin
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THEFT ,CRIME scene searches ,CRIMINAL evidence ,CRIMINAL investigation ,FORENSIC sciences - Abstract
In the present article, the author presents the main aspects that need to be clarified during the investigation of thefts, both in theory, and in judicial practice in this domain. [ABSTRACT FROM AUTHOR]
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- 2012
50. How the signs and symptoms of common infections vary with age.
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Perry, Margaret
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The article discusses the ways in which common infections may vary in terms of signs and symptoms in different age groups. It states that the differences of signs of illnesses among younger people and the elderly present difficulties in diagnosis and assessment. It cites the aspects of various diseases common to the older age group including urinary tract infection (UTI), pneumonia and influenza.
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- 2012
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