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28. Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study

Author

Legrand, Matthieu, Pirracchio, Romain, Rosa, Anne, Petersen, Maya L, Van der Laan, Mark, Fabiani, Jean-Noël, Fernandez-gerlinger, Marie-paule, Podglajen, Isabelle, Safran, Denis, Cholley, Bernard, and Mainardi, Jean-Luc

Abstract

Abstract Introduction Cardiac surgery is frequently needed in patients with infective endocarditis (IE). Acute kidney injury (AKI) often complicates IE and is associated with poor outcomes. The purpose of the study was to determine the risk factors for post-operative AKI in patients operated on for IE. Methods A retrospective, non-interventional study of prospectively collected data (2000–2010) included patients with IE and cardiac surgery with cardio-pulmonary bypass. The primary outcome was post-operative AKI, defined as the development of AKI or progression of AKI based on the acute kidney injury network (AKIN) definition. We used ensemble machine learning (“Super Learning”) to develop a predictor of AKI based on potential risk factors, and evaluated its performance using V-fold cross validation. We identified clinically important predictors among a set of risk factors using Targeted Maximum Likelihood Estimation. Results 202 patients were included, of which 120 (59%) experienced a post-operative AKI. 65 (32.2%) patients presented an AKI before surgery while 91 (45%) presented a progression of AKI in the post-operative period. 20 patients (9.9%) required a renal replacement therapy during the post-operative ICU stay and 30 (14.8%) died during their hospital stay. The following variables were found to be significantly associated with renal function impairment, after adjustment for other risk factors: multiple surgery (OR: 4.16, 95% CI: 2.98-5.80, p

Published
2013

29. Malignancy with Cavoatrial Extension

Author

Alsac, Jean-Marc, Achouh, Paul, Du Puymontbrun, Eleonora, Bel, Alain, Jouan, Jerome, Salvi, Suzanna, Pouly, Julia, Fabiani, Jean-Noël, Azoulay, Daniel, editor, Lim, Chetana, editor, and Salloum, Chady, editor

Published
2017
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38. First clinical use of a bioprosthetic total artificial heart: report of two cases

Author

Carpentier, Alain, Latrémouille, Christian, Cholley, Bernard, Smadja, David M, Roussel, Jean-Christian, Boissier, Elodie, Trochu, Jean-Noël, Gueffet, Jean-Pierre, Treillot, Michèle, Bizouarn, Philippe, Méléard, Denis, Boughenou, Marie-Fazia, Ponzio, Olivier, Grimmé, Marc, Capel, Antoine, Jansen, Piet, Hagège, Albert, Desnos, Michel, Fabiani, Jean-Noël, and Duveau, Daniel

Published
2015
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41. Standardized approach to valve repair using an expansible aortic ring versus mechanical Bentall: Early outcomes of the CAVIAAR multicentric prospective cohort study

Author

Lansac, Emmanuel, Bouchot, Olivier, Arnaud Crozat, Eric, Hacini, Rachid, Doguet, Fabien, Demaria, Roland, Leguerrier, Alain, Jouan, Jerome, Chatel, Didier, Lopez, Stephane, Folliguet, Thierry, Acar, Christophe, Leprince, Pascal, Langanay, Thierry, Jegaden, Oliver, Bessou, Jean Paul, Albat, Bernard, Latremouille, Christian, Fabiani, Jean-Noel, Fayad, Georges, Fleury, Jean Pierre, Pasquet, Blandine, Debauchez, Mathieu, Di Centa, Isabelle, and Tubach, Florence

Published
2015
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