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3. BCL2 expression but not MYC and BCL2 coexpression predicts survival in elderly patients with diffuse large B-cell lymphoma independently of cell of origin in the phase 3 LNH03-6B trial

Author

Petrella, T., Copie-Bergman, C., Brière, J., Delarue, R., Jardin, F., Ruminy, P., Thieblemont, C., Figeac, M., Canioni, D., Feugier, P., Fabiani, B., Leroy, K., Parrens, M., André, M., Haioun, C., Salles, G.A., Gaulard, P., Tilly, H., Jais, J.P., and Molina, T.J.

Published
2017
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12. EARLY POSITRON EMISSION TOMOGRAPHY RESPONSE‐ADAPTED TREATMENT IN LOCALIZED DIFFUSE LARGE B‐CELL LYMPHOMA (AAIPI=0) : RESULTS OF THE PHASE 3 LYSA LNH 09‐1B TRIAL

Author

Bologna, S, primary, Vander Borght, T, additional, Briere, J, additional, Ribrag, V, additional, Damaj, G. L, additional, Thieblemont, C, additional, Feugier, P, additional, Peyrade, F, additional, Lebras, L, additional, Coso, D, additional, Sibon, D, additional, Bonnet, C, additional, Morschhauser, F, additional, Ghesquieres, H, additional, Becker, S, additional, Olivier, P, additional, Fabiani, B, additional, Tilly, H, additional, Haioun, C, additional, and Bastie, J. N, additional

Published
2021
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33. TANSLOCATIONS INVOLVING CD28 ARE RARE IN PERIPHERAL T-CELL LYMPHOMAS

Author

Vallois, D., primary, Dupuy, A., additional, Lemonnier, F., additional, Fataccioli, V., additional, Ortonne, N., additional, Allen, G., additional, Tournilhac, O., additional, Delarue, R., additional, Rousselet-Chapeau, M., additional, Fabiani, B., additional, Llamas-Gutierrez, F., additional, Ko, Y.H., additional, Kataoka, K., additional, Gaulard, P., additional, and de Leval, L., additional

Published
2017
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34. Une présentation très rare d’une maladie très fréquente : une polyarthrite rhumatoïde révélée par une diarrhée secondaire à une amylose AA digestive

Author

Galmiche, S., primary, Buob, D., additional, Bachmeyer, C., additional, Kim, Y., additional, M’bappe, P., additional, Fabiani, B., additional, Fellahi, S., additional, Bastard, J.P., additional, Mattioni, S., additional, Sellam, J., additional, Grateau, G., additional, and Georgin-Lavialle, S., additional

Published
2017
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36. A PHASE II LYSA STUDY OF OBINUTUZUMAB COMBINED WITH LENALIDOMIDE FOR RELAPSED OR REFRACTORY FOLLICULAR B-CELL LYMPHOMA

Author

Morschhauser, F., primary, Le Gouill, S., additional, Feugier, P., additional, Van Den Neste, E., additional, Nicolas-Virelizier, E., additional, Bijou, F., additional, Salles, G.A., additional, Tilly, H., additional, Van Eygen, K., additional, Van Hoof, A., additional, Bonnet, C., additional, Haioun, C., additional, Bouabdallah, R., additional, Fabiani, B., additional, Xerri, L., additional, Cartron, G., additional, and Houot, R., additional

Published
2017
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37. EZH2 alterations in follicular lymphoma: biological and clinical correlations

Author

Huet, S, primary, Xerri, L, additional, Tesson, B, additional, Mareschal, S, additional, Taix, S, additional, Mescam-Mancini, L, additional, Sohier, E, additional, Carrère, M, additional, Lazarovici, J, additional, Casasnovas, O, additional, Tonon, L, additional, Boyault, S, additional, Hayette, S, additional, Haioun, C, additional, Fabiani, B, additional, Viari, A, additional, Jardin, F, additional, and Salles, G, additional

Published
2017
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38. Pseudo-Peritoneal Carcinomatosis Presentation of a Crystal-Storing Histiocytosis With an Unmutated Monoclonal κ Light Chain

Author

Aline-Fardin, A, Bender, Sébastien, Fabiani, B, Buob, D, Brahimi, S, Verpont, MC, Mothy, M, Ronco, P, Boffa, JJ, Aucouturier, P, Garderet, L., Carrion, Claire, Contrôle de la Réponse Immune B et des Lymphoproliférations (CRIBL), and Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, [SDV.IMM] Life Sciences [q-bio]/Immunology, Macrophages, Antineoplastic Agents, Kidney, Boronic Acids, Monoclonal Gammopathy of Undetermined Significance, Bortezomib, Immunoglobulin kappa-Chains, Pyrazines, Humans, [SDV.IMM]Life Sciences [q-bio]/Immunology, Clinical Case Report, Lymph Nodes, Crystallization, Histiocytosis, Peritoneal Neoplasms, Research Article, Aged
Abstract

International audience; Crystal-storing histiocytosis (CSH) is a rare complication of monoclonal gammopathies caused by accumulation of crystalline material inside macrophages, and it may result in a variety of clinical manifestations depending on the involved organs. Although immunoglobulin κ light chains (LCs) seem to be the most frequent pathogenic component, very few molecular data are currently available.A 69-year-old man presented with a very poor performance status. Remarkable features were mesenteric lymph node enlargement and proteinuria, including a monoclonal κ LC. Light and electron microscopy studies revealed the presence of crystals within macrophages in the lymph nodes, bone marrow, and kidney, leading to the diagnosis of CSH. The pathogenic κ LC variable domain sequence was identical to the germline Vk3-2001/Jk201 gene segments, without any somatic mutation, suggesting an extra-follicular B cell proliferation.The patient was successfully treated with 4 cycles of bortezomib and dexamethasone. After a 12-month follow-up, he remains in hematological and renal remission.CSH may present as pseudo-peritoneal carcinomatosis and relate to a monoclonal κ LC encoded by an unmutated gene. Bortezomib-based therapy proved efficacious in this case.

Published
2015

39. Epstein-Barr virus and gastric carcinoma in Western patients: comparison of pathological parameters and p53 expression in EBV-positive and negative tumours

Author

Tepper M, Chapel F, Champault G, Catherine Guettier, Martine Raphael, Fabiani B, and Davi F

Subjects
Pathology, medicine.medical_specialty, Histology, Stromal cell, biology, General Medicine, Dendritic cell, medicine.disease, medicine.disease_cause, biology.organism_classification, Epstein–Barr virus, Herpesviridae, Pathology and Forensic Medicine, hemic and lymphatic diseases, Monoclonal, Carcinoma, medicine, Immunohistochemistry, Gammaherpesvirinae
Abstract

Aims The presence of Epstein–Barr virus (EBV) was studied in 56 gastric carcinomas from Western patients by in-situ hybridization for EBV-encoded RNAs (EBER). EBV-positive and negative carcinomas were compared for various pathological parameters including p53 overexpression. Methods and results EBERs transcripts were detected in seven cases overall: four cases of 52 conventional carcinomas (7.7%) and three cases of four gastric carcinomas with lymphoid stroma (75%). EBER positivity was diffuse in five cases and restricted to a localized area of the tumour in two cases of conventional carcinoma. A monoclonal EBV genomic pattern was demonstrated in the case tested by Southern blot analysis. By immunohistochemical analysis, neither EBV latent or lytic cycle proteins nor C3d/EBV receptor were expressed by neoplastic cells. EBER positivity was significantly correlated with prominent lymphoid reaction (P = 0.0002) which was associated with numerous PS100-positive dendritic cells and with HLA-DR expression by tumour cells (P = 0.03). p53 immunoreactivity in more than 30% of tumour cells was detected in 25 out 49 EBV-negative cases and was absent in EBV-positive cases except in one case with focal EBER-positivity. Conclusions Focal staining for EBER is an unusual finding in the setting of gastric carcinoma and these results suggest that there might be two types of EBV-associated gastric carcinoma in which the viral infection will play a different role. The presence of a stromal lymphoid reaction which is strongly correlated with EBV positivity, is associated with antigen-presenting ability by HLA-DR-positive tumour cells or abundant dendritic cells. The function of p53 appears preserved in all EBV-associated carcinomas except in one case with focal EBER expression whereas the immunohistochemical pattern of p53 is suggestive of a mutational phenomenon in 51% of EBV-negative cases.

Published
2000

42. Immune-checkpoint expression in Epstein-Barr virus positive and negative plasmablastic lymphoma: a clinical and pathological study in 82 patients

Author

Laurent, C., primary, Fabiani, B., additional, Do, C., additional, Tchernonog, E., additional, Cartron, G., additional, Gravelle, P., additional, Amara, N., additional, Malot, S., additional, Palisoc, M. M., additional, Copie-Bergman, C., additional, Glehen, A. T., additional, Copin, M.-C., additional, Brousset, P., additional, Pittaluga, S., additional, Jaffe, E. S., additional, and Coppo, P., additional

Published
2016
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44. Treatment of obstructed defecation syndrome due to rectocele and rectal intussusception with a high volume stapler (TST STARR-plus).

Author

Naldini, G., Fabiani, B., Menconi, C., Giani, I., Toniolo, G., Mascagni, D., and Martellucci, J.

Subjects
*DEFECATION disorders, *RECTOCELE, *INTUSSUSCEPTION in children, *DISEASE relapse, *SURGICAL complications, *PATIENT satisfaction
Abstract

Background: In recent years, stapled transanal resection (STARR) has been adopted worldwide with convincing short-term results. However, due to the high recurrence rate and some major complications after STARR, there is still controversy about when the procedure is indicated. The aim of this study was to assess the safety, efficacy and feasibility of STARR performed with a new dedicated device for tailored transanal stapled surgery.Methods: All the consecutive patients affected by obstructed defecation syndrome (ODS) due to rectocele or/and rectal intussusception, who underwent STARR with the TST STARR-Plus stapler, were included in a prospective study. Pain, Cleveland Clinic Score for Constipation (CCCS) and incontinence, patient satisfaction, number of hemostatic stitches, operative time, hospital stay and perioperative complications were recorded. Postoperative complications and recurrence were also reported.Results: Forty-five consecutive patients (median age 50; range 24–79) were included in the study. Median resected volume was 15 cm3 (range 12–19 cm3) with a median height of surgical specimen of 5.6 cm (range 4.5–10 cm). The mean CCCS decreased from 17.26 (± 3.77) to 5.42 (± 2.78) postoperatively (p < 0.001). Patient satisfaction grade was excellent in 14 patients (31.1%), good in 25 (55.5%), sufficient in three (6.7%) and poor in three patients (6.7%). No major complications occurred. Five patients (11%) reported urgency after 30 days and two patients (4%) after 12 months. The Cleveland Clinic Incontinence score did not significantly change. At a median follow-up of 23 months (range 12–30 months), only three patients (6.7%) reported recurrent symptoms of obstructed defecation comparable to those reported at baseline.Conclusions: TST STARR-Plus seems to be safe and effective for the treatment of ODS due to rectocele and rectal intussusception, and technical improvement could reduce the risk of some complications. However, careful patient selection is still the best means of preventing complications. [ABSTRACT FROM AUTHOR]

Published
2018
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45. Corrigendum: Extreme Drought in the Brazilian Pantanal in 2019–2020: Characterization, Causes, and Impacts

Author

Jose A. Marengo, Ana P. Cunha, Luz Adriana Cuartas, Karinne R. Deusdará Leal, Elisangela Broedel, Marcelo E. Seluchi, Camila Miranda Michelin, Cheila Flávia De Praga Baião, Eleazar Chuchón Angulo, Elton K. Almeida, Marcos L. Kazmierczak, Nelson Pedro António Mateus, Rodrigo C. Silva, and Fabiani Bender

Subjects
Pantanal, drought, river levels, biodiversity, fires, Environmental technology. Sanitary engineering, TD1-1066
Published
2022
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47. Angioimmunoblastic T-cell lymphoma is the most common T-cell lymphoma in two distinct French information data sets

Author

de Leval, L., primary, Parrens, M., additional, Le Bras, F., additional, Jais, J.-P., additional, Fataccioli, V., additional, Martin, A., additional, Lamant, L., additional, Delarue, R., additional, Berger, F., additional, Arbion, F., additional, Bossard, C., additional, Copin, M.-C., additional, Canioni, D., additional, Charlotte, F., additional, Damaj, G., additional, Dartigues, P., additional, Fabiani, B., additional, Ledoux-Pilon, A., additional, Montagne, K., additional, Molina, T., additional, Patey, M., additional, Tas, P., additional, Peoch, M., additional, Petit, B., additional, Petrella, T., additional, Picquenot, J.-M., additional, Rousset, T., additional, Rousselet, M.-C., additional, Soubeyran, I., additional, Thiebault, S., additional, Tournilhac, O., additional, Xerri, L., additional, Gisselbrecht, C., additional, Haioun, C., additional, Delsol, G., additional, and Gaulard, P., additional

Published
2015
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48. [CT and MR virtual colonscopy: indications, limits and comparison with conventional colonscopy]

Author

Bertini, L., Campagnano, S., Lanciotti, S., Fiorello, S., Fabiani, B., Graziani, M. G., and Gualdi, Gianfranco

Subjects
Colonography, Computed Tomographic, Colonoscopy, Colorectal Neoplasms, diagnosis/radiography, Diagnosis, Differential, Humans, Magnetic Resonance Imaging, Predictive Value of Tests, Sensitivity and Specificity, User-Computer Interface, Colonoscopy, diagnosis/radiography, Magnetic Resonance Imaging, Sensitivity and Specificity, Diagnosis, Differential, User-Computer Interface, Predictive Value of Tests, Diagnosis, Differential, Humans, Colorectal Neoplasms, Colonography, Computed Tomographic, Computed Tomographic
Abstract

Virtual endoscopy is a new method for studying the colon; it consists in acquisition of CT and MR images and to elaborate them with a workstation, to create endoluminal vision as like as traditional colonscopy, permitting the complete exploration of colonic lumen, also with stenotic tumors. The analysis of the differences between CT and MR colography shows like these two techniques present both advantages and disadvantages, such as the impossibility to perform MR in patients with pace-maker or in claustrophobic patients and the impossibility to perform CT with iodated agents in patients with renal failure or with a story of adverse reactions. The increased use of these techniques is due to the high sensitivity of last-generation CT and MR machine, to the increased spatial resolution, to specific softwares for digital cleaning of colon, to the introduction of high-end workstations and to the possibility of computed assisted diagnosis (CAD). So, it is desiderable that the increasing spread of multidetector CT devices and the future technical innovations, should have the effect to increase culture and experience in various diagnostic centers about CT-colography, making possible the spreading of virtual endoscopy as a screening tool.

Published
2006

50. [Large cell variant of small cell carcinoma of the ovary with hypercalcemia]

Author

SOPHIE FERLICOT, Bessoud B, Martin V, Branchereau S, Fabiani B, Fourré C, Brailly S, Gueris J, Valteau D, Gauthier F, and Fabre M

Subjects
Cell Nucleus, Diagnosis, Differential, Ovarian Neoplasms, Microscopy, Electron, Adolescent, Hypercalcemia, Humans, Female, Carcinoma, Small Cell, Immunohistochemistry
Abstract

We describe an original distinct type of ovarian small cell carcinoma: large cell variant. The distinctive histologic features of tumor cells were the presence of large nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Immunohistochemistry revealed strong diffuse vimentin, smooth muscle actin positivity and slight reactivity with epithelial markers. Electron microscopy showed aggregates of intermediate filaments, intercellular attachments and no dense core granules. This tumor is associated with paraendocrine hypercalcemia in two thirds of cases. Parathyroid hormone-related protein was focally positive. This tumor is characterized as a very lethal neoplasm, occurring primarily in young women.

Published
1998

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