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Your search keyword '"Fabienne Beckers‐Wesche"' showing total 2 results
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2 results on '"Fabienne Beckers‐Wesche"'

1. Better outcome at lower costs after implementing a CRT‐care pathway: comprehensive evaluation of real‐world data

Author

Antonius M.W. vanStipdonk, Stijn Schretlen, Wim Dohmen, Christian Knackstedt, Fabienne Beckers‐Wesche, Luuk Debie, Hans‐Peter Brunner‐La Rocca, and Kevin Vernooy

Subjects
Cardiac resynchronization therapy, Heart failure, Care pathway, Value‐based health care, Cost‐effectiveness, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Aims Cardiac resynchronization therapy (CRT) requires intensive, complex, and multidisciplinary care for heart failure (HF) patients. Due to limitations in time, resources, and coordination of care, in current practice, this is often incomplete. We evaluated the effect of the introduction of a CRT‐care pathway (CRT‐CPW) on clinical outcome and costs. Methods and results The CRT‐CPW focused on structuring CRT patient selection, implantation, and follow‐up management. To facilitate and guarantee quality, checklists were introduced. The CRT‐CPW was implemented in the Maastricht University Medical Centre in 2014. Physician‐led usual care was restructured to a nurse‐led care pathway. A retrospective comparison of data from CRT patients receiving usual care (2012–2014, 222 patients) and patients receiving care according to CRT‐CPW (2015–2018, 241 patients) was performed. The primary outcome was the composite of all‐cause mortality and HF hospitalization. Hospital‐related costs of cardiovascular care after CRT implantation were analysed to address cost‐effectiveness of the CRT‐CPW. Demographics were comparable in the usual care and CRT‐CPW groups. Kaplan–Meier estimates of the occurrence of the primary endpoint showed a significant improvement in the CRT‐CPW group (25.7% vs. 34.7%, hazard ratio 0.56; confidence interval 0.40–0.78; P

Published
2022
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2. Fluid REStriction in Heart Failure vs Liberal Fluid UPtake: Rationale and Design of the Randomized FRESH-UP Study

Author

Job J. Herrmann, Fabienne Beckers-Wesche, Lisette E.H.J.M. Baltussen, Marjolein H.I. Verdijk, Louise Bellersen, Hans-Peter Brunner-la Rocca, Tiny Jaarsma, Ron Pisters, Sandra Sanders-van Wijk, Laura Rodwell, Niels Van Royen, D.H. Frank Gommans, Roland R.J. Van Kimmenade, MUMC+: MA Cardiologie (3), Cardiologie, RS: Carim - H02 Cardiomyopathy, and ACS - Atherosclerosis & ischemic syndromes

Subjects
Heart Failure, Kardiologi, All institutes and research themes of the Radboud University Medical Center, Chronic Disease, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Quality of Life, Humans, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], Cardiac and Cardiovascular Systems, Chronic heart failure, Fluid restriction, Liberal fl uid intake, Quality of life, Cardiology and Cardiovascular Medicine, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
Abstract

Aims: It is common practice for clinicians to advise fluid restriction in patients with heart failure (HF), but data from clinical trials are lacking. Moreover, fluid restriction is associated with thirst distress and may adversely impact quality of life (QoL). To address this gap in evidence, the Fluid REStriction in Heart failure vs liberal fluid UPtake (FRESH-UP) study was initiated. Methods: The FRESH-UP study is a randomized, controlled, open-label, multicenter trial to investigate the effects of a 3-month period of liberal fluid intake vs fluid restriction (1500 mL/day) on QoL in outpatients with chronic HF (New York Heart Association Classes II-III). The primary aim is to assess the effect on QoL after 3 months using the Overall Summary Score of the Kansas City Cardiomyopathy Questionnaire (KCCQ). Thirst distress, as assessed by the Thirst Distress Scale for patients with HF, KCCQ Clinical Summary Score, each of the KCCQ domains and clinically meaningful changes in these scores, the EQ-5D-5L, patient-reported fluid intake and safety (ie, death, HF hospitalizations) are secondary outcomes. The FRESH-UP study is registered at ClinicalTrials.gov (NCT04551729). Conclusion: The results of the FRESH-UP study will add substantially to the level of evidence concerning fluid management in chronic HF and may impact the QoL of these patients. Funding Agencies|Dutch Heart Foundation [2019T100]; Radboud University Medical Centre in Nijmegen [R0005106]; Maastricht University Medical Centre [R0005106]

Published
2022

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