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22 results on '"Facemire, Paul"'

1. The Comparative Pathology of Intranasal, Intratracheal, or Small Particle Aerosol Exposure of SARS-CoV-2 (COVID-19) Virus in Five Animal Models

Author

Raymond, Jo Lynne W., Cline, Curtis R., Lee, Eric D., Kim, Robert K., Moreau, Alicia M., Wang, Guanghua, Zeng, Xiankun, Williams, Janice A., and Facemire, Paul R.

Subjects
Epidemics -- Research -- China, Medical research -- Analysis, Medicine, Experimental -- Analysis, Homeopathy -- Materia medica and therapeutics, Therapeutics -- Analysis -- Research, Disease transmission -- Research, Vaccines -- Research, Primates -- Research -- Analysis, Coronaviruses -- Analysis -- Research, Hamsters -- Research -- Analysis, Health
Abstract

INTRODUCTION Since the early months of 2020, when the global medical and scientific community began to grasp the magnitude of the emerging pandemic, an effort to understand the disease was [...]

Published
2023

3. Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods

Author

Bell, Todd M., primary, Facemire, Paul, additional, Bearss, Jeremy J., additional, Raymond, Jo Lynne, additional, Chapman, Jennifer, additional, Zeng, Xiankun, additional, Shamblin, Joshua D., additional, Williams, Janice A., additional, Grosenbach, Douglas W., additional, Hruby, Dennis E., additional, Damon, Inger K., additional, Goff, Arthur J., additional, and Mucker, Eric M., additional

Published
2024
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6. Eastern equine encephalitis virus rapidly infects and disseminates in the brain and spinal cord of cynomolgus macaques following aerosol challenge

Author

Williams, Janice A., primary, Long, Simon Y., additional, Zeng, Xiankun, additional, Kuehl, Kathleen, additional, Babka, April M., additional, Davis, Neil M., additional, Liu, Jun, additional, Trefry, John C., additional, Daye, Sharon, additional, Facemire, Paul R., additional, Iversen, Patrick L., additional, Bavari, Sina, additional, Pitt, Margaret L., additional, and Nasar, Farooq, additional

Published
2022
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7. Detailed analysis of the pathologic hallmarks of Nipah virus (Malaysia) disease in the African green monkey infected by the intratracheal route

Author

Cline, Curtis, primary, Bell, Todd M., additional, Facemire, Paul, additional, Zeng, Xiankun, additional, Briese, Thomas, additional, Lipkin, W. Ian, additional, Shamblin, Joshua D., additional, Esham, Heather L., additional, Donnelly, Ginger C., additional, Johnson, Joshua C., additional, Hensley, Lisa E., additional, Honko, Anna N., additional, and Johnston, Sara C., additional

Published
2022
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8. Ebola virus persistence and disease recrudescence in the brains of antibody-treated nonhuman primate survivors

Author

Liu, Jun, primary, Trefry, John C., additional, Babka, April M., additional, Schellhase, Christopher W., additional, Coffin, Kayla M., additional, Williams, Janice A., additional, Raymond, Jo Lynne W., additional, Facemire, Paul R., additional, Chance, Taylor B., additional, Davis, Neil M., additional, Scruggs, Jennifer L., additional, Rossi, Franco D., additional, Haddow, Andrew D., additional, Zelko, Justine M., additional, Bixler, Sandra L., additional, Crozier, Ian, additional, Iversen, Patrick L., additional, Pitt, Margaret L., additional, Kuhn, Jens H., additional, Palacios, Gustavo, additional, and Zeng, Xiankun, additional

Published
2022
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9. Natural History of Aerosol-Induced Ebola Virus Disease in Rhesus Macaques

Author

Downs, Isaac, primary, Johnson, Joshua C., additional, Rossi, Franco, additional, Dyer, David, additional, Saunders, David L., additional, Twenhafel, Nancy A., additional, Esham, Heather L., additional, Pratt, William D., additional, Trefry, John, additional, Zumbrun, Elizabeth, additional, Facemire, Paul R., additional, Johnston, Sara C., additional, Tompkins, Erin L., additional, Jansen, Nathan K., additional, Honko, Anna, additional, and Cardile, Anthony P., additional

Published
2021
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12. Eastern Equine Encephalitis Virus Rapidly Infects and Disseminates in the Brain and Spinal Cord of Infected Cynomolgus Macaques Following Aerosol Challenge

Author

Williams, Janice A, primary, Long, Simon Y, additional, Zeng, Xiankun, additional, Kuehl, Kathleen, additional, Babka, April M, additional, Davis, Neil M, additional, Liu, Jun, additional, Trefry, John C, additional, Daye, Sharon, additional, Facemire, Paul R, additional, Iversen, Patrick L, additional, Bavari, Sina, additional, Pitt, Margaret L, additional, and Nasar, Farooq, additional

Published
2020
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14. A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever

Author

Cashman, Kathleen A., primary, Wilkinson, Eric R., additional, Shaia, Carl I., additional, Facemire, Paul R., additional, Bell, Todd M., additional, Bearss, Jeremy J., additional, Shamblin, Joshua D., additional, Wollen, Suzanne E., additional, Broderick, Kate E., additional, Sardesai, Niranjan Y., additional, and Schmaljohn, Connie S., additional

Published
2017
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19. Congenital Neuroglial Heterotopia in a Neonatal Harbor Seal (Phoca vitulina richardsi ) with Evidence of Recent Exposure to Polycyclic Aromatic Hydrocarbons

Author

Harris, Heather S., primary, Facemire, Paul, additional, Greig, Denise J., additional, Colegrove, Kathleen M., additional, Ylitalo, Gina M., additional, Yanagida, Gladys K., additional, Nutter, Felicia B., additional, Fleetwood, Michelle, additional, and Gulland, Frances M. D., additional

Published
2011
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21. Ebola virus persistence and disease recrudescence in the brains of antibody-treated nonhuman primate survivors

Author

Liu, Jun, Trefry, John C., Babka, April M., Schellhase, Christopher W., Coffin, Kayla M., Williams, Janice A., Raymond, Jo Lynne W., Facemire, Paul R., Chance, Taylor B., Davis, Neil M., Scruggs, Jennifer L., Rossi, Franco D., Haddow, Andrew D., Zelko, Justine M., Bixler, Sandra L., Crozier, Ian, Iversen, Patrick L., Pitt, Margaret L., Kuhn, Jens H., Palacios, Gustavo, and Zeng, Xiankun

Abstract

Effective therapeutics have been developed against acute Ebola virus disease (EVD) in both humans and experimentally infected nonhuman primates. However, the risk of viral persistence and associated disease recrudescence in survivors receiving these therapeutics remains unclear. In contrast to rhesus macaques that survived Ebola virus (EBOV) exposure in the absence of treatment, we discovered that EBOV, despite being cleared from all other organs, persisted in the brain ventricular system of rhesus macaque survivors that had received monoclonal antibody (mAb) treatment. In mAb-treated macaque survivors, EBOV persisted in macrophages infiltrating the brain ventricular system, including the choroid plexuses. This macrophage infiltration was accompanied by severe tissue damage, including ventriculitis, choroid plexitis, and meningoencephalitis. Specifically, choroid plexus endothelium-derived EBOV infection led to viral persistence in the macaque brain ventricular system. This resulted in apoptosis of ependymal cells, which constitute the blood–cerebrospinal fluid barrier of the choroid plexuses. Fatal brain-confined recrudescence of EBOV infection manifested as severe inflammation, local pathology, and widespread infection of the ventricular system and adjacent neuropil in some of the mAb-treated macaque survivors. This study highlights organ-specific EBOV persistence and fatal recrudescent disease in rhesus macaque survivors after therapeutic treatment and has implications for the long-term follow-up of human survivors of EVD.

Published
2021
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22. Cercopithecine Herpesvirus 9 (Simian Varicella Virus) Infection after Total-Body Irradiation in a Rhesus Macaque (Macaca mulatta).

Author

Gulani J, Koch A, Chappell MG, Christensen CL, Facemire P, Singh VK, Ossetrova NI, Srinivasan V, and Holt RK

Subjects
Animals, Herpesviridae Infections pathology, Herpesviridae Infections virology, Immunohistochemistry, Male, Monkey Diseases virology, Herpesviridae Infections veterinary, Herpesvirus 1, Cercopithecine radiation effects, Macaca mulatta virology, Monkey Diseases pathology, Whole-Body Irradiation adverse effects
Abstract

This case report describes a rhesus macaque (Macaca mulatta; male; age, 5 y; weight, 6.7 kg) with anorexia, dehydration, lethargy, ataxia, and generalized skin rashes that occurred 30 d after total-body irradiation at 6.5 Gy ((60)Co γ-rays). Physical examination revealed pale mucus membranes, a capillary refill time of 4 s, heart rate of 180 bpm. and respirations at 50 breaths per minute. Diffuse multifocal maculopapulovesicular rashes were present on the body, including mucocutaneous junctions. The CBC analysis revealed a Hct of 48%, RBC count of 6.2 × 10(6)/μL, platelet count of 44 × 10(3)/μL, and WBC count of 25 × 10(3)/μL of WBC. The macaque was euthanized in light of a grave prognosis. Gross examination revealed white foci on the liver, multifocal generalized petechiation on serosal and mucosal surfaces of the gastrointestinal tract, hemorrhagic lymph nodes, and hemorrhagic fluid in the thoracic cavity. Microscopic examination revealed cutaneous vesicular lesions with intranuclear eosinophilic viral inclusions within the epithelial cells, consistent with herpesvirus. Immunohistochemistry was positive for herpesvirus. The serum sample was negative for antibodies against Macacine herpesvirus 1 and Cercopithecine herpesvirus 9 (simian varicella virus, SVV). Samples submitted for PCR-based identification of the etiologic agent confirmed the presence of SVV DNA. PCR analysis, immunohistochemistry, and histology confirmed that lesions were attributed to an active SVV infection in this macaque. This case illustrates the importance of screening for SVV in rhesus macaques, especially those used in studies that involve immunosuppressive procedures.

Published
2016

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