1. MixInYeast: A Multicenter Study on Mixed Yeast Infections
- Author
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Julio García-Rodríguez, Lourdes Viñuela, Carole Cassagne, Juergen Prattes, Sevtap Arikan-Akdagli, Stéphane Bretagne, Aleksandra Barac, Juan Carlos Soto-Debran, Patricia Muñoz, Işın Akyar, Tomasz Jagielski, Hamid Badali, Danila Seidel, Carmen Barroso Castro, Rocio Tejero, Ana Perez-Ayala Balzola, Giuliana Lo Cascio, Arunaloke Chakrabarti, Sadegh Khodavaisy, María Carmen Martínez-Rubio, Maite Ruiz Pérez de Pipaón, Thanwa Wongsuk, Teresa Peláez, Ana Alastruey-Izquierdo, Yasemin Cag, Raphael Stauf, Elżbieta Ochman, Jörg Steinmann, Joseph Meletiadis, Ana Isabel Suárez-Barrenechea, Cornelia Lass-Flörl, Laura Trovato, Narda Medina, Celia Cardozo, Emmanuel Roilides, Juliette Guitard, Hossein Zarrinfar, Iwona Żak, Martin Hoenigl, Petr Hamal, Eric Dannaoui, University of Belgrade [Belgrade], Laboratoire de Parasitologie-Mycologie [CHU Saint Louis, Paris], Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Cité (UPCité), Istanbul Medeniyet University [Istanbul, Turquie] (IMU), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Post Graduate Institute of Medical Education & Research [Chandigarh, India], Dynamic Microbiology - EA 7380 (DYNAMIC), École nationale vétérinaire - Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est (UPE)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of California [San Diego] (UC San Diego), University of California (UC), Medical University of Graz, Department of Applied Microbiology [Warsaw], Institute of Microbiology [Warsaw], Faculty of Biology [Warsaw], University of Warsaw (UW)-University of Warsaw (UW)-Faculty of Biology [Warsaw], University of Warsaw (UW)-University of Warsaw (UW), Biomedicina, Biotecnología y Salud Pública, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Service de Parasitologie - Mycologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Acibadem University Dspace
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Microbiology (medical) ,polymicrobial infections ,medicine.medical_specialty ,Medizin ,Plant Science ,yeast ,Article ,Microbiology ,Vaccine Related ,03 medical and health sciences ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Amphotericin B ,Biodefense ,Epidemiology ,Medicine ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,030212 general & internal medicine ,Candida albicans ,Prospective cohort study ,lcsh:QH301-705.5 ,Ecology, Evolution, Behavior and Systematics ,Candida ,0303 health sciences ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,biology ,030306 microbiology ,business.industry ,Prevention ,Invasive candidiasis ,invasive candidiasis ,biology.organism_classification ,medicine.disease ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Yeast ,Corpus albicans ,3. Good health ,Infectious Diseases ,Multicenter study ,lcsh:Biology (General) ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Antimicrobial Resistance ,business ,Infection ,chrome agar ,medicine.drug ,mix infections - Abstract
Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epidemiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe accounted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were Candida albicans/C. glabrata (42, 34.4%), C. albicans/C. parapsilosis (17, 14%), and C. glabrata/C. tropicalis (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions. Funding: research grant and GileadSciences research grant. Sí
- Published
- 2021
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