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1. Durable left ventricular assist devices following temporary circulatory support on a microaxial flow pump with and without extracorporeal life support

Author

Lewin, Daniel, Rojas, Sebastian V., Billion, Michael, Meyer, Anna L., Netuka, Ivan, Kooij, Janajade, Pieri, Marina, Loforte, Antonio, Szymanski, Mariusz K., Moeller, Christian H., Akhyari, Payam, Jawad, Khalil, Krasivskyi, Ihor, Schmack, Bastian, Färber, Gloria, Medina, Marta, Haneya, Assad, Zimpfer, Daniel, Nersesian, Gaik, Oezkur, Mehmet, Djordjevic, Ilija, Saeed, Diyar, Stein, Julia, Kraaijeveld, Adriaan O., Gustafsson, Finn, Scandroglio, Mara, Meyns, Bart, Hofmann, Steffen, Belohlavek, Jan, Gummert, Jan F., Lanmueller, Pia, Bernhardt, Alexander M., and Potapov, Evgenij V.

Published
2024
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2. Deactivation of LVAD support for myocardial recovery—surgical perspectives

Author

Nickel, Ian, Potapov, Evgenij, Sun, Benjamin, Zimpfer, Daniel, Koliopoulou, Antigone, Adachi, Iki, Anyanwu, Anelechi, Falk, Volkmar, Atluri, Pavan, Faerber, Gloria, Goldstein, Daniel, Yarboro, Leora, Slaughter, Mark S., Milano, Carmelo, Tsukashita, Masaki, D’Alessandro, David, Silvestry, Scott, Kirov, Hristo, Bommareddi, Swaroop, Lanmüller, Pia, Doenst, Torsten, and Selzman, Craig H.

Published
2024
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4. A multicenter evaluation of external outflow graft obstruction with a fully magnetically levitated left ventricular assist device

Author

Wert, Leonhard, Stewart, Garrick C., Mehra, Mandeep R., Milwidsky, Assi, Jorde, Ulrich P., Goldstein, Daniel J., Selzman, Craig H., Stehlik, Josef, Alshamdin, Faisal D., Khaliel, Feras H., Gustafsson, Finn, Boschi, Silvia, Loforte, Antonio, Ajello, Silvia, Scandroglio, Anna M., Tučanová, Zuzana, Netuka, Ivan, Schlöglhofer, Thomas, Zimpfer, Daniel, Zijderhand, Casper F., Caliskan, Kadir, Dogan, Günes, Schmitto, Jan D., Maier, Sven, Schibilsky, David, Jawad, Khalil, Saeed, Diyar, Faerber, Gloria, Morshuis, Michiel, Hanuna, Maja, Müller, Christoph S., Mulzer, Johanna, Kempfert, Jörg, Falk, Volkmar, and Potapov, Evgenij V.

Published
2024
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6. Pacemaker implantation after concomitant tricuspid valve repair in patients undergoing minimally invasive mitral valve surgery: Results from the Mini-Mitral International Registry

Author

Faerber, Gloria, Berretta, Paolo, Nguyen, Tom C., Wilbring, Manuel, Lamelas, Joseph, Stefano, Pierluigi, Kempfert, Jörg, Rinaldi, Mauro, Pacini, Davide, Pitsis, Antonios, Gerdisch, Marc, Dinh, Nguyen Hoang, Van Praet, Frank, Salvador, Loris, Yan, Tristan, Bonaros, Nikolaos, Fiore, Antonio, Doenst, Torsten, and Di Eusanio, Marco

Published
2024
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9. Propensity matched comparison of TAVI and SAVR in intermediate-risk patients with severe aortic stenosis and moderate-to-severe chronic kidney disease: a subgroup analysis from the German Aortic Valve Registry

Author

Mas-Peiro, Silvia, Faerber, Gloria, Bon, Dimitra, Herrmann, Eva, Bauer, Timm, Bleiziffer, Sabine, Bekeredjian, Raffi, Böning, Andreas, Frerker, Christian, Beckmann, Andreas, Möllmann, Helge, Ensminger, Stephan, Hamm, Christian W., Beyersdorf, Friedhelm, Fichtlscherer, Stephan, and Walther, Thomas

Published
2022
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10. Sex differences among patients receiving ticagrelor monotherapy or aspirin after coronary bypass surgery: A prespecified subgroup analysis of the TiCAB trial

Author

Grothusen, Christina, Cremer, Jochen, Attmann, Tim, Friedrich, Ivar, Oberhoffer, Martin, Knosalla, Christoph, Walther, Thomas, Wimmer-Greinecker, Gerhard, Siepe, Matthias, Grubitzsch, Herko, Joost, Alexander, Schaefer, Andreas, Misfeld, Martin, Laufer, Günther, Wiedemann, Dominik, Englberger, Lars, Hambrecht, Rainer, Sandner, Sigrid, Kastrati, Adnan, Niessner, Alexander, Böning, Andreas, Zeymer, Uwe, Conradi, Lenard, Danner, Bernhard, Zimpfer, Daniel, Färber, Gloria, Manville, Emely, Schunkert, Heribert, and von Scheidt, Moritz

Published
2023
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14. Association between caseload volume and outcomes in left ventricular assist device implantations - a EUROMACS analysis

Author

Mihalj, Maks, Reineke, David, Just, Isabell A., Mulzer, Johanna, Cholevas, Nikolaos, Hoermandinger, Christoph, Veen, Kevin, Luedi, Markus M., Heinisch, Paul Philipp, Potapov, Evgenij, Gummert, Jan F., Mohacsi, Paul, Hagl, Christian, Faerber, Gloria, Zimpfer, Daniel, de By, Theo M. M. H., Meyns, Bart, Gustafsson, Finn, Hunziker, Lukas, Siepe, Matthias, Schober, Patrick, Schoenrath, Felix, Mihalj, Maks, Reineke, David, Just, Isabell A., Mulzer, Johanna, Cholevas, Nikolaos, Hoermandinger, Christoph, Veen, Kevin, Luedi, Markus M., Heinisch, Paul Philipp, Potapov, Evgenij, Gummert, Jan F., Mohacsi, Paul, Hagl, Christian, Faerber, Gloria, Zimpfer, Daniel, de By, Theo M. M. H., Meyns, Bart, Gustafsson, Finn, Hunziker, Lukas, Siepe, Matthias, Schober, Patrick, and Schoenrath, Felix

Abstract

Aims This EUROMACS study was conducted with the primary aim of investigating the association between a centre's annual caseload and postoperative outcomes among patients undergoing left ventricular assist device (LVAD) implantation. Methods and results A total of 4802 patients identified between 2011 and 2020 from 35 participating centres were dichotomized based on the annual caseload of the treating centre at the time of device implant (<= 30 vs. >30 LVAD implantations/year). The primary endpoint was 1-year survival. Secondary outcomes included overall survival analysis, device-related adverse events and readmissions. Cumulative follow-up was 10 003 patient-years, with a median follow-up of 1.54 years (interquartile range 0.52-3.15). Patients from higher volume centres more frequently presented in INTERMACS levels 1 and 2, suffered from right heart dysfunction and needed inotropic support. No difference was observed in adjusted 1-year survival. Adjusted overall survival probability was lower in higher volume centres (p = 0.002). In the subgroup analysis of HeartMate 3 devices only, higher volume centres were associated with decreased odds of 1-year survival (adjusted odds ratio 0.43, 95% confidence interval 0.20-0.97, p = 0.041). Similar findings were observed in the cumulative (i.e. learning curve) caseload analyses. Conclusion In patients undergoing LVAD implantation, centre volume was not associated with 1-year survival, but was related to device-related adverse events. Patient profiles differed with respect to centre size. These findings underscore the necessity for ongoing quality improvement initiatives in all centres, regardless of their annual caseload. Efforts are needed to standardize patient selection and preconditioning to further improve patient outcome.

Published
2024

17. Cytokine Hemoadsorption During Cardiac Surgery Versus Standard Surgical Care for Infective Endocarditis (REMOVE): Results From a Multicenter Randomized Controlled Trial

Author

Diab, Mahmoud, Lehmann, Thomas, Bothe, Wolfgang, Akhyari, Payam, Platzer, Stephanie, Wendt, Daniel, Deppe, Antje-Christin, Strauch, Justus, Hagel, Stefan, Günther, Albrecht, Faerber, Gloria, Sponholz, Christoph, Franz, Marcus, Scherag, André, Velichkov, Ilia, Silaschi, Miriam, Fassl, Jens, Hofmann, Britt, Lehmann, Sven, Schramm, Rene, Fritz, Georg, Szabo, Gabor, Wahlers, Thorsten, Matschke, Klaus, Lichtenberg, Artur, Pletz, Mathias W., Gummert, Jan F., Beyersdorf, Friedhelm, Hagl, Christian, Borger, Michael A., Bauer, Michael, Brunkhorst, Frank M., and Doenst, Torsten

Published
2022
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18. Temporary Mechanical Circulatory Support in Cardiogenic Shock Patients after Cardiac Procedures: Selection Algorithm and Weaning Strategies

Author

Nersesian, Gaik, primary, Ott, Sascha, additional, Fardman, Alexander, additional, Lanmueller, Pia, additional, Lewin, Daniel, additional, Bernhardt, Alexander, additional, Emrich, Fabian, additional, Faerber, Gloria, additional, Szabó, Gábor, additional, Oezkur, Mehmet, additional, Panholzer, Bernd, additional, Rojas, Sebastian V., additional, Saeed, Diyar, additional, Schmack, Bastian, additional, Warnecke, Gregor, additional, Zimpfer, Daniel, additional, Grubitzsch, Herko, additional, Falk, Volkmar, additional, and Potapov, Evgenij, additional

Published
2023
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21. Cardiac surgery 2017 reviewed

Author

Doenst, Torsten, Kirov, Hristo, Moschovas, Alexandros, Gonzalez-Lopez, David, Safarov, Rauf, Diab, Mahmoud, Bargenda, Steffen, and Faerber, Gloria

Published
2018
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22. Impact of preoperative mitral regurgitation on left ventricular assist device patients: propensity score-matched analysis of the EUROMACS dataset

Author

Loforte, Antonio, primary, Nersesian, Gaik, additional, Lewin, Daniel, additional, Lanmueller, Pia, additional, Gliozzi, Gregorio, additional, Stein, Julia, additional, Cavalli, Giulio Giovanni, additional, Schoenrath, Felix, additional, Netuka, Ivan, additional, Zimpfer, Daniel, additional, de By, Theo M M H, additional, Gummert, Jan, additional, Falk, Volkmar, additional, Meyns, Bart, additional, Faerber, Gloria, additional, Pacini, Davide, additional, and Potapov, Evgenij, additional

Published
2023
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24. Cardiac surgery 2016 reviewed

Author

Doenst, Torsten, Essa, Yasin, Jacoub, Khalil, Moschovas, Alexandros, Gonzalez-Lopez, David, Kirov, Hristo, Diab, Mahmoud, Bargenda, Steffen, and Faerber, Gloria

Published
2017
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25. Association of liver dysfunction with outcomes after cardiac surgery—a meta-analysis

Author

Kirov, Hristo, primary, Caldonazo, Tulio, additional, Audisio, Katia, additional, Rahouma, Mohamed, additional, Robinson, N Bryce, additional, Cancelli, Gianmarco, additional, Soletti, Giovanni J, additional, Demetres, Michelle, additional, Ibrahim, Mudathir, additional, Faerber, Gloria, additional, Gaudino, Mario, additional, and Doenst, Torsten, additional

Published
2022
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26. A multicenter evaluation of external outflow graft obstruction with a fully magnetically levitated left ventricular assist device

Author

Wert, Leonhard, primary, Stewart, Garrick C., additional, Mehra, Mandeep R., additional, Milwidsky, Assi, additional, Jorde, Ulrich P., additional, Goldstein, Daniel J., additional, Selzman, Craig H., additional, Stehlik, Josef, additional, Alshamdin, Faisal D., additional, Khaliel, Feras H., additional, Gustafsson, Finn, additional, Boschi, Silvia, additional, Loforte, Antonio, additional, Ajello, Silvia, additional, Scandroglio, Anna M., additional, Tučanová, Zuzana, additional, Netuka, Ivan, additional, Schlöglhofer, Thomas, additional, Zimpfer, Daniel, additional, Zijderhand, Casper F., additional, Caliskan, Kadir, additional, Dogan, Günes, additional, Schmitto, Jan D., additional, Maier, Sven, additional, Schibilsky, David, additional, Jawad, Khalil, additional, Saeed, Diyar, additional, Faerber, Gloria, additional, Morshuis, Michiel, additional, Hanuna, Maja, additional, Müller, Christoph S., additional, Mulzer, Johanna, additional, Kempfert, Jörg, additional, Falk, Volkmar, additional, and Potapov, Evgenij V., additional

Published
2022
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29. Cardiac surgery 2015 reviewed

Author

Doenst, Torsten, Strüning, Constanze, Moschovas, Alexandros, Gonzalez-Lopez, David, Essa, Yasin, Kirov, Hristo, Diab, Mahmoud, and Faerber, Gloria

Published
2016
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30. Cardiac surgery 2014 reviewed

Author

Doenst, Torsten, Strüning, Constanze, Moschovas, Alexandros, Gonzalez-Lopez, David, Valchanov, Ilija, Kirov, Hristo, Diab, Mahmoud, and Faerber, Gloria

Published
2015
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32. Impact of an In-Hospital Endocarditis Team and a State-Wide Endocarditis Network on Perioperative Outcomes

Author

Diab, Mahmoud, Franz, Marcus, Hagel, Stefan, Guenther, Albrecht, Struve, Antonio, Musleh, Rita, Penzel, Anika, Sponholz, Christoph, Lehmann, Thomas, Kuehn, Henning, Ibrahim, Karim, Jahnecke, Marcus, Sigusch, Holger, Ebelt, Henning, Faerber, Gloria, Witte, Otto W., Loeffler, Bettina, Bauer, Michael, Pletz, Mathias W., Schulze, P. Christian, and Doenst, Torsten

Subjects
infective endocarditis, Medicine, endocarditis team, Article, endocarditis network
Abstract

Background: Infective endocarditis (IE) requires multidisciplinary management. We established an endocarditis team within our hospital in 2011 and a state-wide endocarditis network with referring hospitals in 2015. We aimed to investigate their impact on perioperative outcomes. Methods: We retrospectively analyzed data from patients operated on for IE in our center between 01/2007 and 03/2018. To investigate the impact of the endocarditis network on referral latency and pre-operative complications we divided patients into two eras: before (n = 409) and after (n = 221) 01/2015. To investigate the impact of the endocarditis team on post-operative outcomes we conducted multivariate binary logistic regression analyses for the whole population. Kaplan–Meier estimates of 5-year survival were reported. Results: In the second era, after establishing the endocarditis network, the median time from symptoms to referral was halved (7 days (interquartile range: 2–19) vs. 15 days (interquartile range: 6–35)), and pre-operative endocarditis-related complications were reduced, i.e., stroke (14% vs. 27%, p &lt, 0.001), heart failure (45% vs. 69%, p &lt, 0.001), cardiac abscesses (24% vs. 34%, p = 0.018), and acute requirement of hemodialysis (8% vs. 14%, p = 0.026). In both eras, a lack of recommendations from the endocarditis team was an independent predictor for in-hospital mortality (adjusted odds ratio: 2.12, 95% CI: 1.27–3.53, p = 0.004) and post-operative stroke (adjusted odds ratio: 2.23, 95% CI: 1.12–4.39, p = 0.02), and was associated with worse 5-year survival (59% vs. 40%, log-rank &lt, 0.001). Conclusion: The establishment of an endocarditis network led to the earlier referral of patients with fewer pre-operative endocarditis-related complications. Adhering to endocarditis team recommendations was an independent predictor for lower post-operative stroke and in-hospital mortality, and was associated with better 5-year survival.

Published
2021

36. Impact of chronic kidney disease in 29 893 patients undergoing transcatheter or surgical aortic valve replacement from the German Aortic Valve Registry

Author

Mas-Peiro, Silvia, Faerber, Gloria, Bon, Dimitra, Herrmann, Eva, Bauer, Timm, Bleiziffer, Sabine, Bekeredjian, Raffi, Boning, Andreas, Frerker, Christian, Beckmann, Andreas, Mollmann, Helge, Vasa-Nicotera, Mariuca, Ensminger, Stephan, Hamm, Christian W., Beyersdorf, Friedhelm, Fichtlscherer, Stephan, Walther, Thomas, Mas-Peiro, Silvia, Faerber, Gloria, Bon, Dimitra, Herrmann, Eva, Bauer, Timm, Bleiziffer, Sabine, Bekeredjian, Raffi, Boning, Andreas, Frerker, Christian, Beckmann, Andreas, Mollmann, Helge, Vasa-Nicotera, Mariuca, Ensminger, Stephan, Hamm, Christian W., Beyersdorf, Friedhelm, Fichtlscherer, Stephan, and Walther, Thomas

Abstract

OBJECTIVES: Chronic kidney disease (CKD) is a key risk factor in patients undergoing transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR). We analysed the impact of estimated glomerular filtration rate (eGFR) and CKD stages on their mid-term survival. METHODS: Data from 29 893 patients enrolled in the German Aortic Valve registry from January 2011 to December 2015 receiving TAVI (n=12 834) or SAVR (n=17 059) at 88 sites were included. The impact of renal impairment, as measured by eGFR and CKD stages, was investigated. The primary end-point was 1-year cumulative all-cause mortality. RESULTS: Higher CKD stages were significantly associated to lower in-hospital, 30-day- and 1-year survival rates. Both TAVI- and SAVR-treated patients in CKD 3a, 3b, 4 and 5 stages showed significant and gradually increasing HR values for 1-year all-cause mortality. The same trend persisted in multivariable analysis, although HR values for CKD 3a and 5 did not reach significance in TAVI patients, whereas CKD 4+5 did not reach statistical significance in SAVR. Likewise, eGFR as a continuous variable was a significant predictor for 1-year mortality, with the best cut-off points being 47.4ml/min/1.73 m(2) for TAVI and 59.8ml/min/1.73 m(2) for SAVR. Significant 8.6% and 9.0% increases in 1-year mortality were observed for every 5-ml reduction in eGFR for TAVI and SAVR, respectively. CONCLUSIONS: CKD >= 3b and CKD >= 3a are the independent major risk factors for mortality in patients undergoing TAVI and SAVR, respectively. In the overall population of patients with severe aortic stenosis, an appropriate stratification based on CKD substage may contribute to a better selection of patients suitable for such therapies.

Published
2021

41. Predictors of Outcome for Aortic Valve Reimplantation Including the Surgeon-A Single-Center Experience

Author

Tkebuchava, Sophie, Tasar, Raphael, Lehmann, Thomas, Faerber, Gloria, Diab, Mahmoud, Breuer, Martin, Franke, Ulrich, Kirov, Hristo, Gummert, Jan, Lichtenberg, Artur, Wahlers, Thorsten, Doenst, Torsten, Tkebuchava, Sophie, Tasar, Raphael, Lehmann, Thomas, Faerber, Gloria, Diab, Mahmoud, Breuer, Martin, Franke, Ulrich, Kirov, Hristo, Gummert, Jan, Lichtenberg, Artur, Wahlers, Thorsten, and Doenst, Torsten

Abstract

Introduction Aortic valve reimplantation is considered technically demanding. We searched for predictors of long-term outcome including the surgeon as risk factor. Methods We selected all aortic valve reimplantations performed in our department between December 1999 and January 2017 and obtained a complete follow-up. The main indications were combined aortic aneurysm plus aortic valve regurgitation (AR), 69% and aortic dissections (15%). In 14%, valves were bicuspid. Cusp repair was performed in 27% of patients. One-third received additional procedures (coronary artery bypass grafting, mitral, or arch surgery). We performed multivariable analyses for independent risk factors of short- and long-term outcomes, including surgeon as variable. Twelve different surgeons operated on 193 patients. We created three groups: surgeons A and B with 84 and 64 procedures, respectively, and surgeon C (10 surgeons for 45 patients). Results Cardiopulmonary bypass and clamp times were 17645 and 130 +/- 24minutes, respectively. In-hospital mortality was 2%. Postoperatively, 5% had mild and 0.5% had moderate AR. Kaplan-Meier's survival estimates, freedom from reoperation, and freedom from severe AR at 12 years were 97 +/- 1, 93 +/- 2, and 91 +/- 3%, respectively. Age and chronic obstructive pulmonary disease appeared as risk factors for perioperative complications by univariate analysis. Age, coronary artery disease, and duration of cardiopulmonary bypass, but not surgeon, presented as risk factors by multivariable analysis. Conclusion The results suggest that if a David procedure is performed successfully, long-term durability may be excellent. They also suggest that good and durable results are possible even with limited experience of the operating surgeon.

Published
2020

47. Lost in circulation.

Author

Kirov, Hristo, Tkebuchava, Sophio, Faerber, Gloria, Diab, Mahmoud, Sandhaus, Tim, and Doenst, Torsten

Subjects
PERCUTANEOUS coronary intervention, BODY mass index, RETAINED surgical items, FOREIGN bodies, MULTIPLE organ failure, CORONARY arteries
Abstract

Background: Device complications in complex percutaneous coronary interventions are rare but potentially deadly. Surgical removal is often required. However, an evaluation of surgical therapy beyond case reports is practically not existent.Methods: We prospectively followed all cases of retained guide wires and/or other devices referred to us for surgical removal between 2015 and 2019 and retrospectively searched our database for such cases between 2010 and 2014.Results: From 2015 on, eight cases were referred for surgical removal from six different cardiology departments. In the 5 years before, there was not a single case. Six patients were operated emergently. Patients were 60.5 ± 5.42 years old, overweight (body mass index 30.1 ± 3.77) and except for one case (left ventricular-assist device) showed preserved ejection fraction (EF) (mean EF 57 ± 18.01). The retained devices were mostly located in the right coronary artery (50%), followed by the circumflex artery (37.5%) and diagonal branch (12.5%). The devices were remnants of guide wires (n = 4), balloon catheters (n = 3), and in one case a rotablator. Full sternotomy was performed in six patients and two received a left-sided minithoracotomy (n = 2). The operations were performed on-pump in five (62.5%) and off-pump in three patients. Complete extraction of the foreign bodies was possible in all patients. Two patients died; one in unrelated multiorgan failure and one due to retained-device-related right heart failure. The other patients survived and had uneventful postoperative courses.Conclusions: Retained foreign bodies from cardiac interventions can be completely removed surgically using individualized approaches. There appears to be a trend toward a rising incidence of such interventional complications. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Predictors of Outcome for Aortic Valve Reimplantation Including the Surgeon—A Single-Center Experience

Author

Tkebuchava, Sophie, additional, Tasar, Raphael, additional, Lehmann, Thomas, additional, Faerber, Gloria, additional, Diab, Mahmoud, additional, Breuer, Martin, additional, Franke, Ulrich, additional, Kirov, Hristo, additional, Gummert, Jan, additional, Lichtenberg, Artur, additional, Wahlers, Thorsten, additional, and Doenst, Torsten, additional

Published
2018
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49. Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure‐Overloaded Hearts

Author

Nguyen, T. Dung, primary, Schwarzer, Michael, additional, Schrepper, Andrea, additional, Amorim, Paulo A., additional, Blum, Daniel, additional, Hain, Claudia, additional, Faerber, Gloria, additional, Haendeler, Judith, additional, Altschmied, Joachim, additional, and Doenst, Torsten, additional

Published
2018
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