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27 results on '"Fahlberg, Marissa"'

1. Non-human primate model of long-COVID identifies immune associates of hyperglycemia

Author

Palmer, Clovis S., Perdios, Chrysostomos, Abdel-Mohsen, Mohamed, Mudd, Joseph, Datta, Prasun K., Maness, Nicholas J., Lehmicke, Gabrielle, Golden, Nadia, Hellmers, Linh, Coyne, Carol, Moore Green, Kristyn, Midkiff, Cecily, Williams, Kelsey, Tiburcio, Rafael, Fahlberg, Marissa, Boykin, Kyndal, Kenway, Carys, Russell-Lodrigue, Kasi, Birnbaum, Angela, Bohm, Rudolf, Blair, Robert, Dufour, Jason P., Fischer, Tracy, Saied, Ahmad A., and Rappaport, Jay

Published
2024
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3. A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates

Author

Phung, Ivy, Rodrigues, Kristen A., Marina-Zárate, Ester, Maiorino, Laura, Pahar, Bapi, Lee, Wen-Hsin, Melo, Mariane, Kaur, Amitinder, Allers, Carolina, Fahlberg, Marissa, Grasperge, Brooke F., Dufour, Jason P., Schiro, Faith, Aye, Pyone P., Lopez, Paul G., Torres, Jonathan L., Ozorowski, Gabriel, Eskandarzadeh, Saman, Kubitz, Michael, Georgeson, Erik, Groschel, Bettina, Nedellec, Rebecca, Bick, Michael, Kaczmarek Michaels, Katarzyna, Gao, Hongmei, Shen, Xiaoying, Carnathan, Diane G., Silvestri, Guido, Montefiori, David C., Ward, Andrew B., Hangartner, Lars, Veazey, Ronald S., Burton, Dennis R., Schief, William R., Irvine, Darrell J., and Crotty, Shane

Published
2023
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4. Declining neutrophil production despite increasing G-CSF levels is associated with chronic inflammation in elderly rhesus macaques

Author

He, Ziyuan, Fahlberg, Marissa D, Takahashi, Naofumi, Slisarenko, Nadia, Rout, Namita, Didier, Elizabeth S, and Kuroda, Marcelo J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Hematology, Aging, Clinical Research, 1.1 Normal biological development and functioning, Underpinning research, Inflammatory and immune system, Good Health and Well Being, Age Factors, Animals, Chronic Disease, Cytokines, Disease Susceptibility, Granulocyte Colony-Stimulating Factor, Hematopoiesis, Inflammation, Inflammation Mediators, Macaca mulatta, Myeloid-Derived Suppressor Cells, Neutrophils, aging, hematopoiesis, myeloid&#8208, derived suppressor cells, polymorphonuclear cells, myeloid-derived suppressor cells, Biochemistry and Cell Biology, Immunology
Abstract

Aging is characterized by a loss of bone marrow hematopoietic tissue, systemic chronic inflammation, and higher susceptibility to infectious and noninfectious diseases. We previously reported the tightly regulated kinetics and massive daily production of neutrophils during homeostasis in adult rhesus macaques aged 3 to 19 yr (equivalent to approximately 10 to 70 yr of age in humans). In the current study, we observed an earlier release of recently dividing neutrophils from bone marrow and greater in-group variability of neutrophil kinetics based on in vivo BrdU labeling in a group of older rhesus macaques of 20-26 yr of age. Comparing neutrophil numbers and circulating cytokine levels in rhesus macaques spanning 2 to 26 yr of age, we found a negative correlation between age and blood neutrophil counts and a positive correlation between age and plasma G-CSF levels. Hierarchic clustering analysis also identified strong associations between G-CSF with the proinflammatory cytokines, IL-1β and MIP-1α. Furthermore, neutrophils from older macaques expressed less myeloperoxidase and comprised higher frequencies of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) compared to the young adult macaques. In summary, we observed an earlier release from bone marrow and a reduced production of neutrophils despite the increased levels of plasma G-CSF, especially in the elderly rhesus macaques. This lower neutrophil production capacity associated with increased production of proinflammatory cytokines as well as an earlier release of less mature neutrophils and PMN-MDSCs may contribute to the chronic inflammation and greater susceptibility to infectious and noninfectious diseases during aging.

Published
2021

5. Long-primed germinal centres with enduring affinity maturation and clonal migration

Author

Lee, Jeong Hyun, Sutton, Henry J., Cottrell, Christopher A., Phung, Ivy, Ozorowski, Gabriel, Sewall, Leigh M., Nedellec, Rebecca, Nakao, Catherine, Silva, Murillo, Richey, Sara T., Torre, Jonathan L., Lee, Wen-Hsin, Georgeson, Erik, Kubitz, Michael, Hodges, Sam, Mullen, Tina-Marie, Adachi, Yumiko, Cirelli, Kimberly M., Kaur, Amitinder, Allers, Carolina, Fahlberg, Marissa, Grasperge, Brooke F., Dufour, Jason P., Schiro, Faith, Aye, Pyone P., Kalyuzhniy, Oleksandr, Liguori, Alessia, Carnathan, Diane G., Silvestri, Guido, Shen, Xiaoying, Montefiori, David C., Veazey, Ronald S., Ward, Andrew B., Hangartner, Lars, Burton, Dennis R., Irvine, Darrell J., Schief, William R., and Crotty, Shane

Published
2022
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6. Author Correction: Long-primed germinal centres with enduring affinity maturation and clonal migration

Author

Lee, Jeong Hyun, Sutton, Henry J., Cottrell, Christopher A., Phung, Ivy, Ozorowski, Gabriel, Sewall, Leigh M., Nedellec, Rebecca, Nakao, Catherine, Silva, Murillo, Richey, Sara T., Torres, Jonathan L., Lee, Wen-Hsin, Georgeson, Erik, Kubitz, Michael, Hodges, Sam, Mullen, Tina-Marie, Adachi, Yumiko, Cirelli, Kimberly M., Kaur, Amitinder, Allers, Carolina, Fahlberg, Marissa, Grasperge, Brooke F., Dufour, Jason P., Schiro, Faith, Aye, Pyone P., Kalyuzhniy, Oleksandr, Liguori, Alessia, Carnathan, Diane G., Silvestri, Guido, Shen, Xiaoying, Montefiori, David C., Veazey, Ronald S., Ward, Andrew B., Hangartner, Lars, Burton, Dennis R., Irvine, Darrell J., Schief, William R., and Crotty, Shane

Published
2023
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7. Acute Respiratory Distress in Aged, SARS-CoV-2–Infected African Green Monkeys but Not Rhesus Macaques

Author

Blair, Robert V., Vaccari, Monica, Doyle-Meyers, Lara A., Roy, Chad J., Russell-Lodrigue, Kasi, Fahlberg, Marissa, Monjure, Chris J., Beddingfield, Brandon, Plante, Kenneth S., Plante, Jessica A., Weaver, Scott C., Qin, Xuebin, Midkiff, Cecily C., Lehmicke, Gabrielle, Golden, Nadia, Threeton, Breanna, Penney, Toni, Allers, Carolina, Barnes, Mary B., Pattison, Melissa, Datta, Prasun K., Maness, Nicholas J., Birnbaum, Angela, Fischer, Tracy, Bohm, Rudolf P., and Rappaport, Jay

Published
2021
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8. Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID

Author

Palmer, Clovis, primary, Perdios, Chrysostomos, additional, Abdel-Mohsen, Mohamed, additional, Mudd, Joseph, additional, Datta, Prasun, additional, Maness, Nicholas, additional, Lehmicke, Gabrielle, additional, Golden, Nadia, additional, Hellmers, Linh, additional, Coyne, Carol, additional, Green, Kristyn Moore, additional, Midkiff, Cecily, additional, Williams, Kelsey, additional, Tiburcio, Rafael, additional, Fahlberg, Marissa, additional, Boykin, Kyndal, additional, Kenway, Carys, additional, Russell-Lodrigue, Kasi, additional, Bohm, Rudolf, additional, Blair, Robert, additional, Dufour, Jason, additional, Fischer, Tracy, additional, Saied, Ahmad, additional, and Rappaport, Jay, additional

Published
2023
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9. Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID

Author

Palmer, Clovis S, primary, Perdios, Chrysostomos, additional, Abdel-Mohsen, Mohamed, additional, Mudd, Joseph, additional, Datta, Prasun, additional, Maness, Nicholas, additional, Lehmicke, Gabrielle, additional, Golden, Nadia, additional, Hellmer, Lihn, additional, Coyne, Carol, additional, Moore Green, Kristyn, additional, Midkiff, Cecily, additional, Williams, Kelsey, additional, Tiburcio, Rafael, additional, Fahlberg, Marissa, additional, Boykin, Kyndal, additional, Kenway, Carys, additional, Russell-Lodrigue, Kasi, additional, Bohm, Rudolf, additional, Blair, Robert V, additional, Dufour, Jason, additional, Fischer, Tracy, additional, Saied, Ahmed, additional, and Rappaport, Jay, additional

Published
2023
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11. Immune outcomes of Zika virus infection in nonhuman primates

Author

Schouest, Blake, Fahlberg, Marissa, Scheef, Elizabeth A., Ward, Matthew J., Headrick, Kyra, Szeltner, Dawn M., Blair, Robert V., Gilbert, Margaret H., Doyle-Meyers, Lara A., Danner, Victoria W., Bonaldo, Myrna C., Wesson, Dawn M., Panganiban, Antonito T., and Maness, Nicholas J.

Published
2020
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12. Recombinant Simian Varicella Virus-Simian Immunodeficiency Virus Vaccine Induces T and B Cell Functions and Provides Partial Protection against Repeated Mucosal SIV Challenges in Rhesus Macaques

Author

Pahar, Bapi, primary, Gray, Wayne, additional, Fahlberg, Marissa, additional, Grasperge, Brooke, additional, Hunter, Meredith, additional, Das, Arpita, additional, Mabee, Christopher, additional, Aye, Pyone Pyone, additional, Schiro, Faith, additional, Hensley, Krystle, additional, Ratnayake, Aneeka, additional, Goff, Kelly, additional, LaBranche, Celia, additional, Shen, Xiaoying, additional, Tomaras, Georgia D., additional, DeMarco, C. Todd, additional, Montefiori, David, additional, Kissinger, Patricia, additional, Marx, Preston A., additional, and Traina-Dorge, Vicki, additional

Published
2022
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13. Laser particle barcoding for multi-pass high-dimensional flow cytometry

Author

Kwok, Sheldon J, primary, Forward, Sarah, additional, Fahlberg, Marissa D, additional, Cosgriff, Sean, additional, Lee, Seung Hyung, additional, Abbott, Geoffrey, additional, Zhu, Han, additional, Minasian, Nicolas H, additional, Vote, A Sean, additional, Martino, Nicola, additional, and Yun, Seok Hyun (Andy), additional

Published
2022
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14. Immunomodulatory potential of in vivo natural killer T (NKT) activation by NKTT320 in Mauritian-origin cynomolgus macaques

Author

Bond, Nell G., primary, Fahlberg, Marissa D., additional, Yu, Shan, additional, Rout, Namita, additional, Tran, Dollnovan, additional, Fitzpatrick-Schmidt, Taylor, additional, Sprehe, Lesli M., additional, Scheef, Elizabeth A., additional, Mudd, Joseph C., additional, Schaub, Robert, additional, and Kaur, Amitinder, additional

Published
2022
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15. Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

Author

Lee, Jeong Hyun, primary, Sutton, Henry, additional, Cottrell, Christopher A., additional, Phung, Ivy, additional, Ozorowski, Gabriel, additional, Sewall, Leigh M., additional, Nedellec, Rebecca, additional, Nakao, Catherine, additional, Silva, Murillo, additional, Richey, Sara T., additional, Torres, Jonathan L., additional, Lee, Wen-Hsin, additional, Georgeson, Erik, additional, Kubitz, Michael, additional, Hodges, Sam, additional, Mullen, Tina-Marie, additional, Adachi, Yumiko, additional, Cirelli, Kimberly M., additional, Kaur, Amitinder, additional, Allers-Hernandez, Carolina, additional, Fahlberg, Marissa, additional, Grasperge, Brooke F., additional, Dufour, Jason P., additional, Schiro, Faith, additional, Aye, Pyone P., additional, Carnathan, Diane G., additional, Silvestri, Guido, additional, Shen, Xiaoying, additional, Montefiori, David C., additional, Veazey, Ronald S., additional, Ward, Andrew B., additional, Hangartner, Lars, additional, Burton, Dennis R., additional, Irvine, Darrell J., additional, Schief, William R., additional, and Crotty, Shane, additional

Published
2021
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16. The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease

Author

Melton, Alexandra, primary, Doyle-Meyers, Lara A., additional, Blair, Robert V., additional, Midkiff, Cecily, additional, Melton, Hunter J., additional, Russell-Lodrigue, Kasi, additional, Aye, Pyone P., additional, Schiro, Faith, additional, Fahlberg, Marissa, additional, Szeltner, Dawn, additional, Spencer, Skye, additional, Beddingfield, Brandon J., additional, Goff, Kelly, additional, Golden, Nadia, additional, Penney, Toni, additional, Picou, Breanna, additional, Hensley, Krystle, additional, Chandler, Kristin E., additional, Plante, Jessica A., additional, Plante, Kenneth S., additional, Weaver, Scott C., additional, Roy, Chad J., additional, Hoxie, James A., additional, Gao, Hongmei, additional, Montefiori, David C., additional, Mankowski, Joseph L., additional, Bohm, Rudolf P., additional, Rappaport, Jay, additional, and Maness, Nicholas J., additional

Published
2021
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17. Blocking α 4 β 7 integrin delays viral rebound in SHIV SF162P3 -infected macaques treated with anti-HIV broadly neutralizing antibodies

Author

Frank, Ines, primary, Cigoli, Mariasole, additional, Arif, Muhammad S., additional, Fahlberg, Marissa D., additional, Maldonado, Stephanie, additional, Calenda, Giulia, additional, Pegu, Amarendra, additional, Yang, Eun Sung, additional, Rawi, Reda, additional, Chuang, Gwo-Yu, additional, Geng, Hui, additional, Liu, Cuiping, additional, Zhou, Tongqing, additional, Kwong, Peter D., additional, Arthos, James, additional, Cicala, Claudia, additional, Grasperge, Brooke F., additional, Blanchard, James L., additional, Gettie, Agegnehu, additional, Fennessey, Christine M., additional, Keele, Brandon F., additional, Vaccari, Monica, additional, Hope, Thomas J., additional, Fauci, Anthony S., additional, Mascola, John R., additional, and Martinelli, Elena, additional

Published
2021
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20. “Acute Respiratory Distress and Cytokine Storm in Aged, SARS-CoV-2 Infected African Green Monkeys, but not in Rhesus Macaques”

Author

Blair, Robert V., primary, Vaccari, Monica, additional, Doyle-Meyers, Lara A., additional, Roy, Chad J, additional, Russell-Lodrigue, Kasi, additional, Fahlberg, Marissa, additional, Monjure, Chris J., additional, Beddingfield, Brandon, additional, Plante, Kenneth S., additional, Plante, Jessica A., additional, Weaver, Scott C., additional, Qin, Xuebin, additional, Midkiff, Cecily C., additional, Lehmicke, Gabrielle, additional, Golden, Nadia, additional, Threeton, Breanna, additional, Penney, Toni, additional, Allers, Carolina, additional, Barnes, Mary B, additional, Pattison, Melissa, additional, Datta, Prasun K, additional, Maness, Nicholas J, additional, Birnbaum, Angela, additional, Fischer, Tracy, additional, Bohm, Rudolf P., additional, and Rappaport, Jay, additional

Published
2020
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22. Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies.

Author

Frank, Ines, Cigoli, Mariasole, Arif, Muhammad S., Fahlberg, Marissa D., Maldonado, Stephanie, Calenda, Giulia, Pegu, Amarendra, Yang, Eun Sung, Rawi, Reda, Chuang, Gwo-Yu, Geng, Hui, Liu, Cuiping, Zhou, Tongqing, Kwong, Peter D., Arthos, James, Cicala, Claudia, Grasperge, Brooke F., Blanchard, James L., Gettie, Agegnehu, and Fennessey, Christine M.

Subjects
SIMIAN immunodeficiency virus, MONOCLONAL antibodies, MACAQUES, INTEGRINS, RHESUS monkeys, IMMUNOGLOBULINS, VIRAL load
Abstract

Integrin blockade may contribute to HIV control: Blocking integrin α4β7 has been shown to have immunomodulatory effects. In a new study, Frank et al. investigated how blocking integrin α4β7 in macaques infected with a simian-human immunodeficiency virus and treated with anti-HIV broadly neutralizing antibodies (bNAbs) could modulate viral load. Their results suggested that the combination of α4β7 blockade and bNAbs may have controlled the virus better and longer than treatment with bNAbs alone. These findings need to be recapitulated in larger studies with a focus on determining the mechanisms and the duration of virologic control, before they can be translated into clinical settings. Anti-HIV broadly neutralizing antibodies (bNAbs) may favor development of antiviral immunity by engaging the immune system during immunotherapy. Targeting integrin α4β7 with an anti-α4β7 monoclonal antibody (Rh-α4β7) affects immune responses in SIV/SHIV-infected macaques. To explore the therapeutic potential of combining bNAbs with α4β7 integrin blockade, SHIVSF162P3-infected, viremic rhesus macaques were treated with bNAbs only (VRC07-523LS and PGT128 anti-HIV antibodies) or a combination of bNAbs and Rh-α4β7 or were left untreated as a control. Treatment with bNAbs alone decreased viremia below 200 copies/ml in all macaques, but seven of eight macaques (87.5%) in the bNAbs-only group rebounded within a median of 3 weeks (95% CI: 2 to 9). In contrast, three of six macaques treated with a combination of Rh-α4β7 and bNAbs (50%) maintained a viremia below 200 copies/ml until the end of the follow-up period; viremia in the other three macaques rebounded within a median of 6 weeks (95% CI: 5 to 11). Thus, there was a modest delay in viral rebound in the macaques treated with the combination antibody therapy compared to bNAbs alone. Our study suggests that α4β7 integrin blockade may prolong virologic control by bNAbs in SHIVSF162P3-infected macaques. [ABSTRACT FROM AUTHOR]

Published
2021
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24. CD8+ lymphocytes modulate Zika virus dynamics and tissue dissemination and orchestrate antiviral immunity

Author

Schouest, Blake, primary, Fahlberg, Marissa, additional, Scheef, Elizabeth A., additional, Ward, Matthew J., additional, Headrick, Kyra, additional, Szeltner, Dawn M., additional, Blair, Robert V., additional, Gilbert, Margaret H., additional, Doyle-Meyers, Lara A., additional, Danner, Victoria W., additional, Bonaldo, Myrna C., additional, Wesson, Dawn M., additional, Panganiban, Antonito T., additional, and Maness, Nicholas J., additional

Published
2018
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27. Blocking α4β7integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies

Author

Frank, Ines, Cigoli, Mariasole, Arif, Muhammad S., Fahlberg, Marissa D., Maldonado, Stephanie, Calenda, Giulia, Pegu, Amarendra, Yang, Eun Sung, Rawi, Reda, Chuang, Gwo-Yu, Geng, Hui, Liu, Cuiping, Zhou, Tongqing, Kwong, Peter D., Arthos, James, Cicala, Claudia, Grasperge, Brooke F., Blanchard, James L., Gettie, Agegnehu, Fennessey, Christine M., Keele, Brandon F., Vaccari, Monica, Hope, Thomas J., Fauci, Anthony S., Mascola, John R., and Martinelli, Elena

Abstract

Description

Published
2021
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