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14 results on '"Falconi, Anastasia"'

5. Long-Lasting Effects of GSPE on Ileal GLP-1R Gene Expression Are Associated with a Hypomethylation of the GLP-1R Promoter in Female Wistar Rats

Author

Ginés, Iris, primary, Gil-Cardoso, Katherine, additional, D’Addario, Claudio, additional, Falconi, Anastasia, additional, Bellia, Fabio, additional, Blay, M Teresa, additional, Terra, Ximena, additional, Ardévol, Anna, additional, Pinent, Montserrat, additional, and Beltrán-Debón, Raúl, additional

Published
2019
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6. Long-Lasting Effects of GSPE on Ileal GLP-1R Gene Expression Are Associated with a Hypomethylation of the GLP-1R Promoter in Female Wistar Rats

Author

Universitat Rovira i Virgili, Gines, Iris; Gil-Cardoso, Katherine; D'Addario, Claudio; Falconi, Anastasia; Bellia, Fabio; Teresa Blay, M.; Terra, Ximena; Ardeyol, Anna; Pinent, Montserrat; Beltran-Debon, Raul, Universitat Rovira i Virgili, and Gines, Iris; Gil-Cardoso, Katherine; D'Addario, Claudio; Falconi, Anastasia; Bellia, Fabio; Teresa Blay, M.; Terra, Ximena; Ardeyol, Anna; Pinent, Montserrat; Beltran-Debon, Raul

Abstract

Flavonoids have been shown to modulate GLP-1 in obesity. GLP-1 induces some of its effects through the intestinal GLP-1 receptor (GLP-1R), though no data exist on how flavonoids affect this receptor. Here, we examine how a dose of grape seed proanthocyanidin extract (GSPE) with anti-obesity activity affects intestinal GLP-1R and analyze whether epigenetics play a role in the long-lasting effects of GSPE. We found that 10-day GSPE administration prior to the cafeteria diet upregulated GLP-1R mRNA in the ileum 17 weeks after the GSPE treatment. This was associated with a hypomethylation of the GLP-1R promoter near the region where the SP1 transcription factor binds. In the colon, the cafeteria diet upregulated GLP-1R without showing any GSPE effect. In conclusion, we have identified long-lasting GSPE effects on GLP-1R gene expression in the ileum that are partly mediated by hypomethylation at the gene promoter and may affect the SP1 binding factor.

Published
2019

8. Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms

Author

Zoratto, Francesca, primary, Romano, Emilia, additional, Pascale, Esterina, additional, Pucci, Mariangela, additional, Falconi, Anastasia, additional, Dell’Osso, Bernardo, additional, Maccarrone, Mauro, additional, Laviola, Giovanni, additional, D’Addario, Claudio, additional, and Adriani, Walter, additional

Published
2017
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13. Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms

Author

Di Francesco, Andrea, primary, Falconi, Anastasia, additional, Di Germanio, Clara, additional, Micioni Di Bonaventura, Maria Vittoria, additional, Costa, Antonio, additional, Caramuta, Stefano, additional, Del Carlo, Michele, additional, Compagnone, Dario, additional, Dainese, Enrico, additional, Cifani, Carlo, additional, Maccarrone, Mauro, additional, and D’Addario, Claudio, additional

Published
2015
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14. Heat shock protein 70 kDa (HSP70) increase in sea bass (Dicentrarchus labrax, L 1758) thymus after vaccination against Listonella anguillarum

Author

Mosca, Francesco, primary, Romano, Nicla, additional, Malatesta, Daniela, additional, Ceccarelli, Giuseppina, additional, Brunetti, Andrea, additional, Bulfon, Chiara, additional, Volpatti, Donatella, additional, Abelli, Luigi, additional, Galeotti, Marco, additional, Falconi, Anastasia, additional, and Tiscar, Pietro G., additional

Published
2012
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