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9 results on '"Fallegger, Robin"'

1. Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice

Author

Masarapu, Yuvarani, Cekanaviciute, Egle, Andrusivova, Zaneta, Westholm, Jakub O., Björklund, Åsa, Fallegger, Robin, Badia-i-Mompel, Pau, Boyko, Valery, Vasisht, Shubha, Saravia-Butler, Amanda, Gebre, Samrawit, Lázár, Enikő, Graziano, Marta, Frapard, Solène, Hinshaw, Robert G., Bergmann, Olaf, Taylor, Deanne M., Wallace, Douglas C., Sylvén, Christer, Meletis, Konstantinos, Saez-Rodriguez, Julio, Galazka, Jonathan M., Costes, Sylvain V., and Giacomello, Stefania

Published
2024
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3. Metabolic Communication by SGLT2 Inhibition

Author

Billing, Anja M., Kim, Young Chul, Gullaksen, Søren, Schrage, Benedikt, Raabe, Janice, Hutzfeldt, Arvid, Demir, Fatih, Kovalenko, Elina, Lassé, Moritz, Dugourd, Aurelien, Fallegger, Robin, Klampe, Birgit, Jaegers, Johannes, Li, Qing, Kravtsova, Olha, Crespo-Masip, Maria, Palermo, Amelia, Fenton, Robert A., Hoxha, Elion, Blankenberg, Stefan, Kirchhof, Paulus, Huber, Tobias B., Laugesen, Esben, Zeller, Tanja, Chrysopolou, Maria, Saez-Rodriguez, Julio, Magnussen, Christina, Eschenhagen, Thomas, Staruschenko, Alexander, Siuzdak, Gary, Poulsen, Per L., Schwab, Clarissa, Cuello, Friederike, Vallon, Volker, and Rinschen, Markus M.

Published
2023
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4. Metabolic Communication by SGLT2 Inhibition

Author

Billing, Anja M., primary, Kim, Young Chul, additional, Gullaksen, Søren, additional, Schrage, Benedikt, additional, Raabe, Janice, additional, Hutzfeldt, Arvid, additional, Demir, Fatih, additional, Kovalenko, Elina, additional, Lassé, Moritz, additional, Dugourd, Aurelien, additional, Fallegger, Robin, additional, Klampe, Birgit, additional, Jaegers, Johannes, additional, Li, Qing, additional, Kravtsova, Olha, additional, Crespo-Masip, Maria, additional, Palermo, Amelia, additional, Fenton, Robert A., additional, Hoxha, Elion, additional, Blankenberg, Stefan, additional, Kirchhof, Paulus, additional, Huber, Tobias B., additional, Laugesen, Esben, additional, Zeller, Tanja, additional, Chrysopoulou, Maria, additional, Saez-Rodriguez, Julio, additional, Magnussen, Christina, additional, Eschenhagen, Thomas, additional, Staruschenko, Alexander, additional, Siuzdak, Gary, additional, Poulsen, Per L., additional, Schwab, Clarissa, additional, Cuello, Friederike, additional, Vallon, Volker, additional, and Rinschen, Markus M., additional

Published
2024
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7. Spatially resolved multiomics on the neuronal effects induced by spaceflight

Author

Masarapu, Yuvarani, primary, Cekanaviciute, Egle, additional, Andrusivova, Zaneta, additional, Westholm, Jakub Orzechowski, additional, Björklund, Åsa, additional, Fallegger, Robin, additional, Badia-i-Mompel, Pau, additional, Boyko, Valery, additional, Vasisht, Shubha, additional, Saravia-Butler, Amanda, additional, Gebre, Samrawit, additional, Lázár, Enikö, additional, Bergmann, Olaf, additional, Taylor, Deanne, additional, Wallace, Douglas, additional, Sylvén, Christer, additional, Rodriguez, Julio Saez, additional, Galazka, Jonathan, additional, Costes, Sylvain, additional, and Giacomello, Stefania, additional

Published
2023
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9. Opening the black box: spatial transcriptomics and the relevance of AI-detected prognostic regions in high grade serous carcinoma

Author

Laury, Anna Ray, Zheng, Shuyu, Aho, Niina, Fallegger, Robin, Hänninen, Satu, Saez-Rodriguez, Julio, Tanevski, Jovan, Youssef, Omar, Tang, Jing, and Carpén, Olli M.

Abstract

Image based deep learning models are used to extract new information from standard H&E pathology slides, however, biological interpretation of the features detected by artificial intelligence (AI) remains a challenge. High-grade serous ovarian carcinoma (HGSC) is characterized by aggressive behavior and chemotherapy resistance, but also by striking variability in outcome. Our understanding of this disease is limited, partly due to considerable tumor heterogeneity. We previously trained an AI model to identify HGSC tumor regions that are highly associated with outcome status but are indistinguishable by conventional morphologic methods. Here we applied spatial transcriptomics to further profile the AI-identified tumor regions in 16 patients (8 per outcome group) and identify molecular features related to disease outcome in patients who underwent primary debulking surgery and platinum-based chemotherapy. We examined FFPE tissue from 1) regions identified by the AI model as highly associated with short or extended chemotherapy response, and 2) background tumor regions (not identified by the AI model as highly associated with outcome status) from the same tumors. We show that the transcriptomic profiles of AI-identified regions are more distinct than background regions from the same tumors, are superior in predicting outcome, and differ in several pathways including those associated with chemoresistance in HGSC. Further, we find that poor outcome and good outcome regions are enriched by different tumor subpopulations, suggesting distinctive interaction patterns. In summary, our work presents proof of concept that AI-guided spatial transcriptomic analysis improves recognition of biologic features relevant to patient outcome.

Published
2024
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