Search

Your search keyword '"Famoroti, T."' showing total 2 results
Start Over Author "Famoroti, T."
2 results on '"Famoroti, T."'

1. Multiplex PCR Detection of Respiratory Tract Infections in SARS-CoV-2-Negative Patients Admitted to the Emergency Department: an International Multicenter Study during the COVID-19 Pandemic

Author

Duclos, M., Hommel, B., Allantaz, F., Powell, M., Posteraro, Brunella, Sanguinetti, Maurizio, Habous, M., Dabal, L., Kilercik, M., Uyar, N. Y., Bozdayi, G., Caglar, K., Otlu, B., Yakupogullari, Y., Karalti, I., Tagiyev, B., Almaghrabi, R. S., Althawadi, S., Qasem, M. G., Alzahrani, A., Streinu-Cercel, A., Schvoerer, E., Hartard, C., Thibault, V., Pronier, C., Henquell, C., Brebion, A., Pillet, S., Labetoulle, R., Silke, P., Ganzenmueller, T., Schmauder, K., Munoz, P., Albizua, A. B., Kabera, B., Maranga, J., Wolter, N., Du Plessis, M., Famoroti, T., Wadula, J., Nunes, M. C., Rashed, H. G., Elkholy, M. M., Yahia, M. B., Elfattah, N. A., Ferjani, A., Boutiba-Ben, I., Hamammi, A., Hakim, H. K., Gdoura, M., and Henda, T.

Subjects
Microbiology (medical), Adult, General Immunology and Microbiology, Ecology, emergency department, Physiology, SARS-CoV-2, respiratory tract infection, COVID-19, Cell Biology, Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, multiplex PCR assay, Infectious Diseases, Genetics, Humans, viral infection, Child, Emergency Service, Hospital, Pandemics, Multiplex Polymerase Chain Reaction, Respiratory Tract Infections
Abstract

Respiratory tract infection (RTI) is a common cause of visits to the hospital emergency department. During the ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), nonpharmaceutical intervention has influenced the rates of circulating respiratory viruses. In this study, we sought to detect RTI etiological agents other than SARS-CoV-2 in emergency department patients from 13 countries in Europe, the Middle East, and Africa from December 2020 to March 2021. We sought to measure the impact of patient characteristics and national-level behavioral restrictions on the positivity rate for RTI agents. Using the BioFire Respiratory Panel 2.0 Plus, 1,334 nasopharyngeal swabs from patients with RTI symptoms who were negative for SARS-CoV-2 were tested. The rate of positivity for viral or bacterial targets was 36.3%. Regarding viral targets, human rhinovirus or enterovirus was the most prevalent (56.5%), followed by human coronaviruses (11.0%) and adenoviruses (9.9%). Interestingly, age stratification showed that the positivity rate was significantly higher in the children's group than in the adults' group (68.8% versus 28.2%). In particular, human rhinovirus or enterovirus, the respiratory syncytial virus, and other viruses, such as the human metapneumovirus, were more frequently detected in children than in adults. A logistic regression model was also used to determine an association between the rate of positivity for viral agents with each country's behavioral restrictions or with patients' age and sex. Despite the impact of behavioral restrictions, various RTI pathogens were actively circulating, particularly in children, across the 13 countries.

Published
2022

2. Prevalence and seasonality of common viral respiratory pathogens, including Cytomegalovirus in children, between 0-5 years of age in KwaZulu-Natal, an HIV endemic province in South Africa.

Author

Famoroti T, Sibanda W, and Ndung'u T

Subjects
Adenovirus Infections, Human epidemiology, Child, Preschool, Coinfection, Comorbidity, Cytomegalovirus Infections epidemiology, Endemic Diseases, Female, Human bocavirus, Humans, Infant, Infant, Newborn, Influenza A virus, Influenza, Human epidemiology, Male, Parvoviridae Infections epidemiology, Picornaviridae Infections epidemiology, Prevalence, Respiratory Syncytial Virus Infections epidemiology, Retrospective Studies, Rhinovirus, South Africa epidemiology, Developing Countries, HIV Infections epidemiology, Respiratory Tract Infections epidemiology, Respiratory Tract Infections virology, Seasons
Abstract

Background: Acute respiratory tract infections contribute significantly to morbidity and mortality among young children in resource-poor countries. However, studies on the viral aetiology of acute respiratory infections, seasonality and the relative contributions of comorbidities such as immune deficiency states to viral respiratory tract infections in children in these countries are limited., Methods: A retrospective analysis of laboratory test results of upper or lower respiratory specimens of children between 0 and 5 years of age collected between 1st January 2011 and 31st July 2015 from hospitals in KwaZulu-Natal, South Africa. Respiratory specimens were tested for viral respiratory pathogens using multiplex polymerase chain reaction (PCR), HIV testing was performed either by serological or PCR methods. Cytomegalovirus (CMV) respiratory infection was determined using the CMV R-gene PCR kit., Results: In total 2172 specimens were analysed, of which 1175 (54.1%) were from males. The median age was 3.0 months (interquartile range [IQR] 1-7). Samples from the lower respiratory tract accounted for 1949 (89.7%) of all specimens. Respiratory multiplex PCR results were positive in 834 (45.7%) specimens. Respiratory syncytial virus (RSV) was the most commonly detected virus in 316 (32.1%) patients, followed by adenovirus (ADV) in 215 (21.8%), human rhinovirus (Hrhino) in 152 (15.4%) and influenza A (FluA) in 50 (5.1%). A seasonal time series pattern was observed for ADV (winter peak), enterovirus (EV) (autumn), human bocavirus (HBoV) (summer), and parainfluenza viruses 1 and 3 (PIV1 and 3) (spring). Stationary or untrended seasonal variation was observed for FluA (winter peak) and RSV (summer). HIV results were available for 1475 (67.9%) specimens; of these 348 (23.6%) were positive. CMV results were available for 714 (32.9%) specimens, of which 416 (58.3%) were positive. There was a statistically significant association between the coinfection of HIV and CMV with ADV., Conclusions: In this study, we identified the most common respiratory viral pathogens detected among hospitalized children in KwaZulu-Natal. The coinfection between HIV and CMV was found to be associated with an increased risk of only adenovirus infection. Most viral pathogens showed a seasonal trend of occurrence. Our data has implications for the rational design of public health programmes.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results