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251 results on '"Famulok M"'

1. Aptamers as Tools in Molecular Biology and Immunology

Author

Famulok, M., Mayer, G., Compans, R. W., editor, Cooper, M., editor, Hogle, J. M., editor, Ito, Y., editor, Koprowski, H., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, Famulok, Michael, editor, Winnacker, Ernst-L., editor, and Wong, Chi-Huey, editor

Published
1999
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9. Poly-Ligand Profiling differentiates pancreatic cancer patients according to treatment benefit from gemcitabine+placebo versus gemcitabine+evofosfamide and identifies candidate targets

Author

Domenyuk, V., primary, Liu, X., additional, Magee, D., additional, Gatalica, Z., additional, Stark, A., additional, Kennedy, P., additional, Rosenow, M., additional, Barker, A., additional, Berry, D., additional, Poste, G., additional, Halbert, D., additional, Hart, C., additional, Famulok, M., additional, Mayer, G., additional, Korn, M., additional, Miglarese, M., additional, and Spetzler, D., additional

Published
2018
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10. Abstract P2-09-09: Polyligand profiling differentiates cancer patients according to their benefit of treatment

Author

Domenyuk, V, primary, Gatalica, Z, additional, Santhanam, R, additional, Wei, X, additional, Stark, A, additional, Kennedy, P, additional, Toussaint, B, additional, Levenberg, S, additional, Wang, R, additional, Xiao, N, additional, Greil, R, additional, Rinnerthaler, G, additional, Gampenrieder, S, additional, Heimberger, AB, additional, Berry, DJ, additional, Barker, A, additional, Demetri, GD, additional, Quackenbush, J, additional, Marshall, JL, additional, Poste, G, additional, Vacirca, JL, additional, Vidal, GA, additional, Schwartzberg, LS, additional, Halbert, DD, additional, Voss, A, additional, Miglarese, MR, additional, Famulok, M, additional, Mayer, G, additional, and Spetzler, D, additional

Published
2018
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11. Target-based discovery of novel inhibitors of enzymatic targets from Wolbachia endosymbionts and evaluation as antifilarial drug candidates

Author

Lentz, CS, Halls, VS, Hannam, JS, Hoerauf, A, Famulok, M, and Pfarr, KM

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Lymphatic Filariasis and Onchocerciasis are neglected tropical diseases caused by parasitic filarial nematodes affecting more than 150 million people worldwide. The final success of mass drug administration programs (MDA) in endemic countries using combination therapies of diethycarbamazine or ivermectin[for full text, please go to the a.m. URL], Infektiologie Update 2014; 24. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG)

Published
2014
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31. Nucleic Acid Aptamers&sbd;From Selection in Vitro to Applications in Vivo

Author

Famulok, M., Mayer, G., and Blind, M.

Abstract

Aptamers are nucleic acid ligands which are isolated from combinatorial oligonucleotide libraries by in vitro selection. They exhibit highly complex and sophisticated molecular recognition properties and are capable of binding tightly and specifically to targets ranging from small molecules to complex multimeric structures. Besides their promising application as molecular sensors, many aptamers targeted against proteins are also able to interfere with the proteins' biological function. Recently developed techniques facilitate the intracellular application of aptamers and their use as in vivo modulators of cellular physiology. Using these approaches, one can quickly obtain highly specific research reagents that act on defined intracellular targets in the context of the living cell.

Published
2000

33. Selective targeting and inhibition of yeast RNA polymerase II by RNA aptamers.

Author

Thomas, M, Chédin, S, Carles, C, Riva, M, Famulok, M, and Sentenac, A

Abstract

To probe the complex nucleic acid binding domains of yeast RNA polymerase II (Pol II), we have isolated in the presence of heparin RNA molecules that selectively bind to yeast Pol II. A class of RNA molecules was found to bind and strongly interfere with enzyme-DNA interaction but not with RNA chain elongation. Remarkably, one selected RNA ligand was a specific inhibitor of Saccharomyces cerevisiae Pol II. S. cerevisiae Pol I and Pol III and Pol II from Schizosaccharomyces pombe or wheat germ cells were not affected. Photocross-linking experiments showed that the RNA ligand preferentially interacted with B220, the largest subunit of Pol II and, to a lesser extent, with B150, the second largest subunit. The selected RNA was expressed in yeast cells under the control of a Pol III promoter. Yeast cells that expressed the anti-Pol II aptamer grew normally. However, a cell growth defect was observed when expressing the RNA aptamer in cells having an artificially reduced level of Pol II.

Published
1997

35. Cytohesins are cytoplasmic ErbB receptor activators

Author

Bill A, Schmitz A, Albertoni B, Jn, Song, Lukas Heukamp, Walrafen D, Thorwirth F, Pj, Verveer, Zimmer S, Meffert L, Schreiber A, Chatterjee S, Rk, Thomas, Rt, Ullrich, Lang T, and Famulok M

Abstract

Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains, which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors contributing to the activation are unknown. Here we identify members of the cytohesin protein family as such factors. Cytohesin inhibition decreased ErbB receptor autophosphorylation and signaling, whereas cytohesin overexpression stimulated receptor activation. Monitoring epidermal growth factor receptor (EGFR) conformation by anisotropy microscopy together with cell-free reconstitution of cytohesin-dependent receptor autophosphorylation indicate that cytohesins facilitate conformational rearrangements in the intracellular domains of dimerized receptors. Consistent with cytohesins playing a prominent role in ErbB receptor signaling, we found that cytohesin overexpression correlated with EGF signaling pathway activation in human lung adenocarcinomas. Chemical inhibition of cytohesins resulted in reduced proliferation of EGFR-dependent lung cancer cells in vitro and in vivo. Our results establish cytohesins as cytoplasmic conformational activators of ErbB receptors that are of pathophysiological relevance.

47. Design and Construction of Novel Peptides and Proteins by Tailored Incorporation of Coenzyme Functionality

Author

Imperiali, Barbara, McDonnell, Kevin A., Shogren-Knaak, Michael, de Meijere, Armin, editor, Houk, K. N., editor, Kessler, Horst, editor, Lehn, Jean-Marie, editor, Ley, Steven V., editor, Schreiber, Stuart L., editor, Thiem, Joachim, editor, Trost, Barry M., editor, Vögtle, Fritz, editor, Yamamoto, Hisashi, editor, Schmidtchen, Franz P., editor, Baltzer, L., editor, Chamberlin, A. R., editor, McDonnell, K. A., editor, Famulok, M., editor, Gilmore, M. A., editor, Imperiali, B., editor, Jenne, A., editor, Shogren-Knaak, M., editor, and Steward, L. E., editor

Published
1999
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48. Catalysis Based on Nucleic Acid Structures

Author

Famulok, Michael, Jenne, Andreas, de Meijere, Armin, editor, Houk, K. N., editor, Kessler, Horst, editor, Lehn, Jean-Marie, editor, Ley, Steven V., editor, Schreiber, Stuart L., editor, Thiem, Joachim, editor, Trost, Barry M., editor, Vögtle, Fritz, editor, Yamamoto, Hisashi, editor, Schmidtchen, Franz P., editor, Baltzer, L., editor, Chamberlin, A. R., editor, McDonnell, K. A., editor, Famulok, M., editor, Gilmore, M. A., editor, Imperiali, B., editor, Jenne, A., editor, Shogren-Knaak, M., editor, and Steward, L. E., editor

Published
1999
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49. Incorporation of Noncoded Amino Acids by In Vitro Protein Biosynthesis

Author

Gilmore, Marcella A., Steward, Lance E., Chamberlin, A. Richard, de Meijere, Armin, editor, Houk, K. N., editor, Kessler, Horst, editor, Lehn, Jean-Marie, editor, Ley, Steven V., editor, Schreiber, Stuart L., editor, Thiem, Joachim, editor, Trost, Barry M., editor, Vögtle, Fritz, editor, Yamamoto, Hisashi, editor, Schmidtchen, Franz P., editor, Baltzer, L., editor, Chamberlin, A. R., editor, McDonnell, K. A., editor, Famulok, M., editor, Gilmore, M. A., editor, Imperiali, B., editor, Jenne, A., editor, Shogren-Knaak, M., editor, and Steward, L. E., editor

Published
1999
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50. Functionalization and Properties of Designed Folded Polypeptides

Author

Baltzer, Lars, de Meijere, Armin, editor, Houk, K. N., editor, Kessler, Horst, editor, Lehn, Jean-Marie, editor, Ley, Steven V., editor, Schreiber, Stuart L., editor, Thiem, Joachim, editor, Trost, Barry M., editor, Vögtle, Fritz, editor, Yamamoto, Hisashi, editor, Schmidtchen, Franz P., editor, Baltzer, L., editor, Chamberlin, A. R., editor, McDonnell, K. A., editor, Famulok, M., editor, Gilmore, M. A., editor, Imperiali, B., editor, Jenne, A., editor, Shogren-Knaak, M., editor, and Steward, L. E., editor

Published
1999
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