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The current reconstructions of the Atlantic Multidecadal Oscillation (AMO) and Pacific Decadal Oscillation (PDO) primarily rely on marine sediment proxies. However, the limited resolution of these records makes it difficult to precisely understand the short‐term dynamics of the PDO and AMO, and consequently, their influence on global climate. This study unveils two new Holocene reconstructions of AMO and PDO derived from a large‐scale compilation of speleothem isotope records (δ18Os) from Chinese monsoon region, in which spatial patterns of summer rainfall are generally accepted as good indicators of internal variability. Principal component analysis applied to Chinese δ18Os records identifies the first principal component as representative of Holocene Asian monsoon (AM) variation. This data‐driven approach reveals a significant shift in hydroclimatic conditions after 8.2 ka, potentially providing valuable insights into the underlying forcing mechanisms driving these changes. The remanent components, which show spatial rainfall patterns, are effectively validated through independent records of AMO and PDO derived from the previous paleo‐proxy based reconstructions and model simulations. The present reconstructions suggest a significantly enhanced stability of the AMO and PDO in the middle Holocene, which may explain the concurrent more stable and optimum climate observed in the AM region. These findings also imply that the Holocene AM intensity recorded in Chinese cave records is largely controlled by external forcing, whereas the regionally heterogenous rainfall is regulated by internal variability. The successful attempt on the Holocene AMO and PDO reconstructions indicates an effective isolation between different modes of climate variability from paleoclimate records. Key Points: Different modes of climate variability are isolated from a large‐scale compilation of Chinese speleothem δ18O recordsHolocene high‐resolution Pacific Decadal Oscillation and Atlantic Multidecadal Oscillation variations are reconstructed based on Chinese speleothem δ18O recordsHigh stability of internal variability in the middle Holocene may explain the Holocene climate optimum [ABSTRACT FROM AUTHOR]

Online retailing provides alternative shopping channels, where the retail platform can either let manufacturers directly sell to consumers or open a self-operated channel, or even both. Regardless of sales channels, consumers often pay attention to the income gap between themselves and enterprises (named consumer's fairness concern). In this work, we explore how consumers' fairness concerns affect the optimal decisions of both manufacturer and retail platform under different retail channel modes (single-channel mode and mixed-channel mode). The results show that consumer's fairness concern has a negative impact on the retail price under low production cost in single-channel mode, while the retail prices in mix-channel mode are jointly determined by consumer's fairness concern and revenue sharing ratio. Besides, if the market channel mode has not yet formed, the retail platform can choose either a self-operated channel or manufacturer consignment channel, depending on the consumer's fairness concern level and revenue sharing ratio. By contrast, if the market channel mode has already been formed, the retail platform should make effort to reduce consumer's fairness concern if only the self-operated channel exists, while maintain consumer's fairness concern and revenue sharing ratio at a moderate level if there exist mixed channels. [ABSTRACT FROM AUTHOR]

Information on moisture variability is important for climate adaptation and planning, which is urgently needed for the Jiuzhaigou County after it was hit by a magnitude 7.0 earthquake in August 2017, resulting in potential interactions between the earth surface processes and the hydroclimate. To study the regional hydroclimatic history beyond instrumental records, the first tree‐ring hydroclimate reconstruction, based on Pinus tabuliformis, was conducted in the southern Min Mountains, which is situated close to the areas affected by the Jiuzhaigou earthquake. The reconstruction, spanning from 1684 to 2017, explained 59% of the variance for May–August standardized precipitation evapotranspiration index at a 12‐month scale during 1962–2017. The recent drought, which occurred from 1992 to 2017 was the longest in duration, largest in magnitude, and had the second highest intensity. The most severe single year drought occurred in 1824, which was lower than the long‐term mean by 4σ and affected several regions in and around the Northeast Qinghai‐Tibet Plateau. The drought reconstruction was consistent with other moisture reconstructions, but dissimilar were also exist during some periods. There was a significant correlation between drought reconstruction and sea surface temperature over many oceans. However, the correlations were unstable over time. This study suggests the importance of developing a density tree‐ring network to identify the spatial and temporal drought variability, as well as long‐term record for understanding regional climate dynamics. [ABSTRACT FROM AUTHOR]

Engineering of functional vascularized pancreatic tissues offers an alternative way to solve the perpetual shortage of organs for transplantation. However, revascularization remains a major bottleneck in biological engineering, which limited the further clinical applications of this strategy. In this study, an efficient approach for enhancing re‐endothelialization of rat decellularized pancreatic scaffolds (DPS) was presented, by conjugating with GRGDSPC peptide to maximize coverage of the vessel walls with human umbilical vein endothelial cells (HUVECs). First, pancreas was perfused with 1% Triton X‐100 and 0.1% ammonium hydroxide to remove the cellular components. Subsequently, GRGDSPC was covalently coupled to the vasculature of DPS and re‐seeded with HUVECs via perfusion of the portal vein in the bioreactor. After the re‐endothelialized scaffolds were created, in vitro and in vivo experiments were undertaken to evaluate the angiogenesis. Our results demonstrated that GRGDSPC‐conjugated scaffolds could support the survival and accelerated the proliferation of HUVECs; angiogenesis was also significantly improved over untreated scaffolds. In conclusion, GRGDSPC‐conjugated scaffolds showed great potential for the generation of functional bioengineered pancreatic tissue suitable for long‐term transplantation. [ABSTRACT FROM AUTHOR]