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23 results on '"Fan, Huimei"'

3. A Preliminary Study of the Potential Molecular Mechanisms of Individual Growth and Rumen Development in Calves with Different Feeding Patterns

Author

Wang, Jie, primary, Zhao, Kaisen, additional, Li, Mianying, additional, Fan, Huimei, additional, Wang, Meigui, additional, Xia, Siqi, additional, Chen, Yang, additional, Bai, Xue, additional, Liu, Zheliang, additional, Ni, Jiale, additional, Sun, Wenqiang, additional, Jia, Xianbo, additional, and Lai, Songjia, additional

Published
2023
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5. Integration of Non-Coding RNA and mRNA Profiles Reveals the Mechanisms of Rumen Development Induced by Different Types of Diet in Calves

Author

Wang, Jie, primary, Fan, Huimei, additional, Li, Mianying, additional, Zhao, Kaisen, additional, Xia, Siqi, additional, Chen, Yang, additional, Shao, Jiahao, additional, Tang, Tao, additional, Bai, Xue, additional, Liu, Zheliang, additional, Lu, Yusheng, additional, Chen, Xiangrui, additional, Sun, Wenqiang, additional, Jia, Xianbo, additional, and Lai, Songjia, additional

Published
2023
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13. Aqueous Extracts of Se-Enriched Auricularia auricular Exhibits Antioxidant Capacity and Attenuate Liver Damage in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

Author

Liu Xiaoxiao, Fan Huimei, Jingjing Wang, Cuicui Duan, and Wei Chunyan

Subjects
0301 basic medicine, Antioxidant, medicine.medical_treatment, Medicine (miscellaneous), Pharmacology, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Glycation, Diabetes mellitus, medicine, chemistry.chemical_classification, 030109 nutrition & dietetics, Nutrition and Dietetics, biology, Glutathione peroxidase, Streptozotocin, Malondialdehyde, medicine.disease, chemistry, Catalase, 030220 oncology & carcinogenesis, biology.protein, Oxidative stress, medicine.drug
Abstract

Oxidative stress triggered by hyperglycemia is thought to be a major factor in the development of liver disease during diabetes mellitus (DM). The aim of this study was to determine the antioxidant capacity of aqueous extracts of selenium-enriched Auricularia auricular (AESA) and further investigate the hepatic protection and potential mechanism of AESA in a mouse model of diabetes. An in vitro antioxidant assay confirmed that AESA exhibited better antioxidant capacity characterized by increased reducing power and scavenging capacity of free radicals, such as diphenyl picrylhydrazyl radical, hydroxyl radical, and superoxide radical. The diabetic model was induced by high-fat diet combined with a single injection of streptozotocin in C57BL/6 mice. Our results showed that AESA treatment improved diabetes-induced disorders of lipid metabolisms and alleviated liver damage in diabetic mice. Furthermore, the antioxidant enzyme activities of glutathione peroxidase and catalase in liver were increased and malondialdehyde level was decreased with AESA treatment compared with those in the DM group. In parallel, AESA significantly reduced the contents of tumor necrosis factor-alpha and interleukin-1beta in liver in comparison with the DM group. In addition, western blot results showed that the expression of receptor for advanced glycation end products (RAGE), phospho-c-Jun NH2-terminal kinase, phospho-extracellular signal-regulated kinase, and phospho-p38 kinase were remarkably decreased in AESA treatment group compared with DM group. Taken together, supplementation of AESA may effectively attenuate diabetic hepatopathology by exerting antioxidant function through the RAGE/mitogen-activated protein kinase pathway.

Published
2020

20. Aqueous extracts of se-enriched Auricularia auricular attenuates D-galactose-induced cognitive deficits, oxidative stress and neuroinflammation via suppressing RAGE/MAPK/NF-κB pathway

Author

Wei Chunyan, Liu Xiaoxiao, Jingjing Wang, Tianzhu Zhang, and Fan Huimei

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Aging, Receptor for Advanced Glycation End Products, Morris water navigation task, Complex Mixtures, medicine.disease_cause, RAGE (receptor), Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, Selenium, 0302 clinical medicine, Internal medicine, medicine, Hippocampus (mythology), Animals, Cognitive Dysfunction, Medicine, Chinese Traditional, Neuroinflammation, chemistry.chemical_classification, Inflammation, Mice, Inbred ICR, biology, General Neuroscience, Glutathione peroxidase, Basidiomycota, NF-kappa B, Galactose, Water, Stereoisomerism, Malondialdehyde, Oxidative Stress, 030104 developmental biology, Endocrinology, chemistry, biology.protein, Solvents, Mitogen-Activated Protein Kinases, 030217 neurology & neurosurgery, Oxidative stress, Signal Transduction
Abstract

Aging is a natural process that accompanied with progressive cognitive deficits and functional decline in organisms. Selenium (Se), an essential trace element, exhibits antioxidative and anti-inflammatory abilities. Here, our study aimed to investigate the protective effects of aqueous extracts of Se-enriched Auricularia auricular (AESAA) on aging mice induced by d -galactose ( D -gal) and explore its potential mechanism. d -gal was administered (100 mg/kg) subcutaneously for 12 weeks to establish an aging mouse model. Morris water maze (MWM) test was conducted to assess the cognitive deficits of mice. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) activities and malondialdehyde (MDA) level in hippocampus were measured to evaluate oxidative stress. The contents of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) in hippocampus were determined by ELISA method. Further, hippocampal levels of RAGE, p-Erk, p-JNK, p-P38 and p-NF-κB were detected by western blot and the RAGE expression was confirmed by immunohistochemistry. We found that AESAA supplementation significantly decreased d -gal-induced cognitive deficits, as evidenced by better performance in the MWM test. Furthermore, AESAA treatment attenuated oxidative stress and decreased the contents of pro-inflammatory cytokines in hippocampus. Importantly, AESAA inhibited the up-regulation of RAGE, p-Erk, p-JNK, p-P38 in the hippocampus of d -gal treated mice. Moreover, the results also indicated that AESAA inhibited p-NF-κB and p-IκBα expression. In conclusion, our findings suggest that AESAA effectively decreases cognitive impairment, alleviates oxidative damage and neuroinflammation in mice through s RAGE/MAPK/NF-κB signaling pathway, which provides a potential therapy for delaying the aging process.

Published
2018

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